Structural position:

  • Domain Type: Ig
  • Aligned Position: 148
  • Secondary Structure Element: h
  • Secondary Structure Region: ⍺-helix

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
A/G 73 Ig-1 68 None 0.1527 None 0.001 N 0.327 0.082 0.119812018005 gnomAD-4.0.0 6.84057E-07 None None None -0.188(TCAP) N None 0 0 None 0 0 None 0 0 8.99292E-07 0 0
E/K 169 Ig-2 66 None 0.5689 None 0.142 D 0.285 0.466 0.399740851666 gnomAD-4.0.0 1.59046E-06 None None None -0.328(TCAP) N None 0 0 None 0 0 None 0 0 2.85647E-06 0 0
E/D 1008 Ig-3 66 None 0.8738 None 0.999 N 0.464 0.305 0.31077124679 gnomAD-4.0.0 1.36821E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79865E-06 0 0
E/K 1008 Ig-3 66 rs756356686 0.9182 0.799 0.999 D 0.623 0.465 0.561981951463 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 1008 Ig-3 66 rs756356686 0.9182 0.799 0.999 D 0.623 0.465 0.561981951463 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.54E-05 0 0 0 None 0 0 0 0 0
E/K 1008 Ig-3 66 rs756356686 0.9182 0.799 0.999 D 0.623 0.465 0.561981951463 gnomAD-4.0.0 2.56143E-06 None None None None I None 0 1.69446E-05 None 0 0 None 0 0 0 1.34002E-05 0
D/G 1149 Ig-4 68 rs781299976 0.8347 -0.149 1.0 N 0.645 0.508 0.163833314356 gnomAD-2.1.1 7.96E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 8.81E-06 0
D/G 1149 Ig-4 68 rs781299976 0.8347 -0.149 1.0 N 0.645 0.508 0.163833314356 gnomAD-4.0.0 4.78887E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69801E-06 3.47802E-05 1.65601E-05
D/N 1149 Ig-4 68 rs368967197 0.643 0.484 1.0 N 0.605 0.34 None gnomAD-2.1.1 1.42E-05 None None None None I None 1.60192E-04 0 None 0 0 None 0 None 0 0 0
D/N 1149 Ig-4 68 rs368967197 0.643 0.484 1.0 N 0.605 0.34 None gnomAD-3.1.2 5.91E-05 None None None None I None 1.92966E-04 6.55E-05 0 0 0 None 0 0 0 0 0
D/N 1149 Ig-4 68 rs368967197 0.643 0.484 1.0 N 0.605 0.34 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
D/N 1149 Ig-4 68 rs368967197 0.643 0.484 1.0 N 0.605 0.34 None gnomAD-4.0.0 1.53663E-05 None None None None I None 1.85598E-04 1.694E-05 None 0 0 None 0 0 0 0 0
D/Y 1149 Ig-4 68 rs368967197 0.9344 0.018 1.0 N 0.707 0.476 0.514866526686 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
D/Y 1149 Ig-4 68 rs368967197 0.9344 0.018 1.0 N 0.707 0.476 0.514866526686 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 1149 Ig-4 68 rs368967197 0.9344 0.018 1.0 N 0.707 0.476 0.514866526686 gnomAD-4.0.0 3.84214E-06 None None None None I None 5.07219E-05 0 None 0 0 None 0 0 0 0 0
E/G 1357 Ig-5 67 None 0.4396 None 1.0 N 0.676 0.506 0.391930172978 gnomAD-4.0.0 1.59078E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8569E-06 0 0
R/G 1770 Ig-8 68 rs780733773 0.8704 -0.228 1.0 N 0.649 0.568 0.647459595057 gnomAD-2.1.1 2.8E-05 None None None None I None 0 8.68E-05 None 0 0 None 0 None 0 2.65E-05 1.63452E-04
R/G 1770 Ig-8 68 rs780733773 0.8704 -0.228 1.0 N 0.649 0.568 0.647459595057 gnomAD-4.0.0 1.16412E-05 None None None None I None 0 8.94534E-05 None 3.82643E-05 0 None 0 0 1.07917E-05 0 0
Y/C 1905 Ig-9 65 rs1265838947 0.9338 0.137 1.0 D 0.663 0.639 None gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
Y/C 1905 Ig-9 65 rs1265838947 0.9338 0.137 1.0 D 0.663 0.639 None gnomAD-4.0.0 1.59051E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02151E-05
Y/H 1905 Ig-9 65 rs1477069650 0.9694 0.505 1.0 N 0.629 0.511 0.49908893446 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
Y/H 1905 Ig-9 65 rs1477069650 0.9694 0.505 1.0 N 0.629 0.511 0.49908893446 gnomAD-4.0.0 2.53106E-05 None None None None N None 0 2.23604E-05 None 0 0 None 0 0 3.14756E-05 0 1.65579E-05
E/K 2144 Ig-10 67 rs747447866 0.267 0.962 0.334 D 0.561 0.288 0.32580497728 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 2144 Ig-10 67 rs747447866 0.267 0.962 0.334 D 0.561 0.288 0.32580497728 gnomAD-4.0.0 1.59074E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/A 2239 Ig-11 66 None 0.0696 None None N 0.074 0.035 0.0297737177859 gnomAD-4.0.0 1.59081E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85696E-06 0 0
S/F 2239 Ig-11 66 rs1486541995 0.1492 -0.813 0.093 N 0.401 0.103 0.277730125212 gnomAD-2.1.1 7.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.55E-05 0
S/F 2239 Ig-11 66 rs1486541995 0.1492 -0.813 0.093 N 0.401 0.103 0.277730125212 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 2239 Ig-11 66 rs1486541995 0.1492 -0.813 0.093 N 0.401 0.103 0.277730125212 gnomAD-4.0.0 3.71776E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08498E-06 0 0
E/G 2420 Ig-13 65 None 0.1157 None 0.978 D 0.491 0.658 0.725532541758 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 2510 Ig-14 66 None 0.4121 None 1.0 D 0.686 0.5 0.207176502487 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 2684 Ig-16 64 rs1008197005 0.1443 None 0.801 N 0.409 0.297 0.0884992946249 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20604E-04 0 0 0 0 None 0 0 0 0 0
D/G 2684 Ig-16 64 rs1008197005 0.1443 None 0.801 N 0.409 0.297 0.0884992946249 gnomAD-4.0.0 1.02447E-05 None None None None N None 1.18339E-04 1.69492E-05 None 0 0 None 0 0 0 0 0
V/M 2772 Ig-17 66 rs143035953 0.0886 -0.118 0.013 D 0.138 0.14 None gnomAD-2.1.1 4.25047E-04 None None None None I None 4.165E-03 8.47E-05 None 0 3.01356E-04 None 1.30659E-04 None 0 1.55E-05 1.38581E-04
V/M 2772 Ig-17 66 rs143035953 0.0886 -0.118 0.013 D 0.138 0.14 None gnomAD-3.1.2 1.03833E-03 None None None None I None 3.54713E-03 3.27182E-04 0 0 5.77367E-04 None 0 0 1.47E-05 2.07125E-04 4.79386E-04
V/M 2772 Ig-17 66 rs143035953 0.0886 -0.118 0.013 D 0.138 0.14 None 1000 genomes 9.98403E-04 None None None None I None 3E-03 0 None None 1E-03 0 None None None 0 None
V/M 2772 Ig-17 66 rs143035953 0.0886 -0.118 0.013 D 0.138 0.14 None gnomAD-4.0.0 2.46573E-04 None None None None I None 4.10426E-03 1.4995E-04 None 0 5.34926E-04 None 0 0 2.54238E-05 1.42729E-04 2.23993E-04
S/A 2859 Ig-18 65 None 0.0551 None None N 0.074 0.073 0.0297737177859 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
E/D 2946 Ig-19 65 None 0.1318 None 0.031 N 0.163 0.298 0.280987212366 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/E 3033 Ig-20 65 rs772024586 0.8994 -0.457 1.0 N 0.787 0.448 0.361558571881 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 4.62E-05 0 0
G/E 3033 Ig-20 65 rs772024586 0.8994 -0.457 1.0 N 0.787 0.448 0.361558571881 gnomAD-4.0.0 1.59062E-06 None None None None N None 0 0 None 0 0 None 1.88168E-05 0 0 0 0
S/C 3122 Ig-21 65 None 0.3565 None 1.0 N 0.671 0.437 0.273503213844 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 3122 Ig-21 65 None 0.1203 None 0.999 N 0.46 0.239 0.124217242631 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 3213 Ig-22 67 rs760666570 0.7961 0.232 0.993 N 0.481 0.253 0.0806252709748 gnomAD-2.1.1 1.99E-05 None None None None N None 0 1.44592E-04 None 0 0 None 0 None 0 0 0
S/R 3213 Ig-22 67 rs760666570 0.7961 0.232 0.993 N 0.481 0.253 0.0806252709748 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/R 3213 Ig-22 67 rs760666570 0.7961 0.232 0.993 N 0.481 0.253 0.0806252709748 gnomAD-4.0.0 4.33729E-06 None None None None N None 0 1.16682E-04 None 0 0 None 0 0 0 0 0
E/D 3532 Ig-25 68 rs368855843 0.247 0.168 None None None 0.232 None gnomAD-2.1.1 8.05E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 8.89E-06 0
E/D 3532 Ig-25 68 rs368855843 0.247 0.168 None None None 0.232 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/D 3532 Ig-25 68 rs368855843 0.247 0.168 None None None 0.232 None gnomAD-4.0.0 1.9214E-05 None None None None I None 2.67001E-05 0 None 0 0 None 0 0 2.45843E-05 0 0
E/K 3532 Ig-25 68 rs2087705976 0.1741 None None None None 0.278 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 3725 Ig-26 66 rs1398496347 0.0866 0.136 None None None 0.072 None gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/I 3725 Ig-26 66 rs1398496347 0.0866 0.136 None None None 0.072 None gnomAD-4.0.0 7.52639E-06 None None None None I None 0 0 None 0 0 None 0 0 9.89452E-06 0 0
E/Q 3885 Ig-27 66 rs761154231 0.145 0.105 0.001 N 0.125 0.064 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/Q 3885 Ig-27 66 rs761154231 0.145 0.105 0.001 N 0.125 0.064 None gnomAD-4.0.0 1.36839E-06 None None None None I None 0 0 None 0 0 None 0 0 1.7989E-06 0 0
E/G 4004 Ig-28 67 rs376000381 0.1091 -0.475 None N 0.153 0.06 None gnomAD-2.1.1 3.22E-05 None None None None I None 3.72393E-04 0 None 0 0 None 0 None 0 0 0
E/G 4004 Ig-28 67 rs376000381 0.1091 -0.475 None N 0.153 0.06 None gnomAD-3.1.2 1.18309E-04 None None None None I None 4.34405E-04 0 0 0 0 None 0 0 0 0 0
E/G 4004 Ig-28 67 rs376000381 0.1091 -0.475 None N 0.153 0.06 None gnomAD-4.0.0 1.7975E-05 None None None None I None 3.87121E-04 0 None 0 0 None 0 0 0 0 0
E/K 4004 Ig-28 67 rs755242569 0.0878 0.662 0.001 N 0.188 0.061 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/K 4004 Ig-28 67 rs755242569 0.0878 0.662 0.001 N 0.188 0.061 None gnomAD-4.0.0 1.09501E-05 None None None None I None 0 0 None 0 0 None 0 0 1.4391E-05 0 0
E/G 4669 Ig-29 64 None 0.1147 None 0.698 D 0.517 0.279 0.307966526162 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 4669 Ig-29 64 rs368543748 0.0805 0.451 0.075 N 0.297 0.201 0.261217442401 gnomAD-2.1.1 7.44E-05 None None None None N None 0 0 None 0 7.93651E-04 None 0 None 0 2.87E-05 0
E/K 4669 Ig-29 64 rs368543748 0.0805 0.451 0.075 N 0.297 0.201 0.261217442401 gnomAD-3.1.2 3.94E-05 None None None None N None 2.41E-05 0 0 0 5.78481E-04 None 0 0 2.94E-05 0 0
E/K 4669 Ig-29 64 rs368543748 0.0805 0.451 0.075 N 0.297 0.201 0.261217442401 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
E/K 4669 Ig-29 64 rs368543748 0.0805 0.451 0.075 N 0.297 0.201 0.261217442401 gnomAD-4.0.0 3.67032E-05 None None None None N None 1.34405E-05 0 None 0 4.7357E-04 None 0 0 2.75838E-05 1.17523E-05 4.91819E-05
V/A 4765 Ig-30 66 rs1192234880 0.2749 0.077 0.002 N 0.094 0.092 0.167679373172 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/A 4765 Ig-30 66 rs1192234880 0.2749 0.077 0.002 N 0.094 0.092 0.167679373172 gnomAD-4.0.0 5.4738E-06 None None None None I None 0 2.23624E-05 None 0 0 None 0 0 5.39688E-06 1.15937E-05 0
V/D 4765 Ig-30 66 rs1192234880 0.7201 None 0.669 N 0.367 0.189 0.468917363747 gnomAD-4.0.0 1.36845E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79896E-06 0 0
Q/K 4860 Ig-31 66 None 0.0861 None 0.006 N 0.166 0.123 0.117506650769 gnomAD-4.0.0 6.84193E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99439E-07 0 0
A/V 5140 Ig-34 66 rs753106533 0.1925 0.035 1.0 D 0.624 0.536 0.638815175438 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/V 5140 Ig-34 66 rs753106533 0.1925 0.035 1.0 D 0.624 0.536 0.638815175438 gnomAD-4.0.0 1.36865E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32035E-05 0
S/G 5233 Ig-35 66 None 0.0691 None 0.007 N 0.198 0.074 0.233785782151 gnomAD-4.0.0 1.59119E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
S/R 5233 Ig-35 66 None 0.246 None 0.884 N 0.33 0.126 0.343560092441 gnomAD-4.0.0 1.59119E-06 None None None None I None 5.65419E-05 0 None 0 0 None 0 0 0 0 0
H/D 5326 Ig-36 66 None 0.107 None 0.049 N 0.213 0.169 0.0846915920261 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 5422 Ig-37 66 rs762625771 0.1141 0.683 0.029 N 0.245 0.084 0.0297737177859 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 5422 Ig-37 66 rs762625771 0.1141 0.683 0.029 N 0.245 0.084 0.0297737177859 gnomAD-4.0.0 6.00203E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25036E-06 0 3.66381E-05
E/G 5609 Ig-39 67 None 0.1027 None 0.822 N 0.473 0.25 0.327419511103 gnomAD-4.0.0 1.59132E-06 None None None None I None 0 0 None 4.76781E-05 0 None 0 0 0 0 0
E/K 5609 Ig-39 67 rs374682077 0.0982 0.85 0.963 N 0.48 0.29 None gnomAD-2.1.1 3.22E-05 None None None None I None 1.65399E-04 2.83E-05 None 0 0 None 3.27E-05 None 0 1.56E-05 1.40647E-04
E/K 5609 Ig-39 67 rs374682077 0.0982 0.85 0.963 N 0.48 0.29 None gnomAD-3.1.2 7.89E-05 None None None None I None 2.41301E-04 0 0 0 0 None 0 0 1.47E-05 0 4.78927E-04
E/K 5609 Ig-39 67 rs374682077 0.0982 0.85 0.963 N 0.48 0.29 None gnomAD-4.0.0 2.04492E-05 None None None None I None 1.73264E-04 1.66639E-05 None 0 4.45752E-05 None 3.12461E-05 0 1.10193E-05 1.0982E-05 1.60067E-05
A/T 5702 Ig-40 66 rs2080567900 0.0747 None None N 0.089 0.078 0.0401082797425 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/T 5702 Ig-40 66 rs2080567900 0.0747 None None N 0.089 0.078 0.0401082797425 gnomAD-4.0.0 6.57203E-06 None None None None I None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
K/E 5795 Ig-41 66 rs1226206785 0.1368 0.228 0.334 N 0.289 0.14 0.126345400529 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/E 5795 Ig-41 66 rs1226206785 0.1368 0.228 0.334 N 0.289 0.14 0.126345400529 gnomAD-4.0.0 3.18243E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71654E-06 0 0
K/Q 5888 Ig-42 66 rs1176630529 0.0787 0.198 None N 0.218 0.076 0.0846915920261 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/Q 5888 Ig-42 66 rs1176630529 0.0787 0.198 None N 0.218 0.076 0.0846915920261 gnomAD-4.0.0 1.59169E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43361E-05 0
T/A 5984 Ig-43 66 rs772384158 0.0608 0.113 None N 0.081 0.077 None gnomAD-2.1.1 4.42E-05 None None None None N None 0 0 None 0 6.12404E-04 None 0 None 0 0 0
T/A 5984 Ig-43 66 rs772384158 0.0608 0.113 None N 0.081 0.077 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 5.78481E-04 None 0 0 1.47E-05 0 0
T/A 5984 Ig-43 66 rs772384158 0.0608 0.113 None N 0.081 0.077 None gnomAD-4.0.0 5.14395E-05 None None None None N None 0 0 None 0 1.8275E-03 None 0 0 8.47696E-07 0 0
T/I 5984 Ig-43 66 None 0.1145 None 0.055 N 0.302 0.136 0.233150807113 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/P 5984 Ig-43 66 None 0.0956 None None N 0.167 0.161 0.0297737177859 gnomAD-4.0.0 6.8428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99562E-07 0 0
T/N 6077 Ig-44 66 rs773941728 0.0807 0.273 0.055 N 0.199 0.108 0.16115917748 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/N 6077 Ig-44 66 rs773941728 0.0807 0.273 0.055 N 0.199 0.108 0.16115917748 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
T/N 6077 Ig-44 66 rs773941728 0.0807 0.273 0.055 N 0.199 0.108 0.16115917748 gnomAD-4.0.0 2.29344E-05 None None None None N None 1.33533E-05 0 None 0 0 None 0 0 3.05173E-05 0 0
G/E 6357 Ig-47 66 rs368765224 0.0918 -0.335 0.061 N 0.314 0.181 0.149567049428 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
G/E 6357 Ig-47 66 rs368765224 0.0918 -0.335 0.061 N 0.314 0.181 0.149567049428 gnomAD-4.0.0 1.36908E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32056E-05 0
G/V 6357 Ig-47 66 rs368765224 0.0796 0.191 0.002 N 0.2 0.185 0.276065633971 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
G/V 6357 Ig-47 66 rs368765224 0.0796 0.191 0.002 N 0.2 0.185 0.276065633971 gnomAD-4.0.0 6.84541E-07 None None None None N None 0 0 None 0 2.52525E-05 None 0 0 0 0 0
Q/E 6450 Ig-48 66 None 0.0556 None 0.001 N 0.077 0.102 0.0551355673512 gnomAD-4.0.0 2.73794E-06 None None None None N None 0 0 None 0 2.52551E-05 None 0 0 2.69902E-06 0 0
E/D 6733 Ig-51 67 rs374881285 0.0992 0.176 0.001 N 0.195 0.14 0.12205267543 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
A/T 6920 Ig-53 67 None 0.0791 None 0.007 N 0.091 0.053 0.162503812791 gnomAD-4.0.0 1.59388E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43724E-05 0
A/V 6920 Ig-53 67 rs886042589 0.1021 0.053 0.016 N 0.14 0.24 0.212008924253 gnomAD-2.1.1 8.07E-06 None None None None N None 6.48E-05 0 None 0 5.59E-05 None 0 None 0 0 0
A/V 6920 Ig-53 67 rs886042589 0.1021 0.053 0.016 N 0.14 0.24 0.212008924253 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/V 6920 Ig-53 67 rs886042589 0.1021 0.053 0.016 N 0.14 0.24 0.212008924253 gnomAD-4.0.0 2.56559E-06 None None None None N None 1.69256E-05 0 None 0 2.42789E-05 None 0 0 0 0 0
Q/K 7013 Ig-54 66 rs1191869265 0.07 0.204 0.003 N 0.131 0.097 0.0482279557977 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 4.64E-05 0 0
Q/K 7013 Ig-54 66 rs1191869265 0.07 0.204 0.003 N 0.131 0.097 0.0482279557977 gnomAD-4.0.0 1.59183E-06 None None None None I None 0 0 None 0 0 None 1.88267E-05 0 0 0 0
S/L 7109 Ig-55 66 rs368530326 0.089 0.213 0.921 N 0.373 0.318 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/L 7109 Ig-55 66 rs368530326 0.089 0.213 0.921 N 0.373 0.318 None gnomAD-4.0.0 3.49011E-05 None None None None N None 0 0 None 0 0 None 0 0 4.49809E-05 0 1.65711E-05
S/P 7109 Ig-55 66 rs2078891499 0.2381 None 0.998 N 0.391 0.347 0.180583059064 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/P 7109 Ig-55 66 rs2078891499 0.2381 None 0.998 N 0.391 0.347 0.180583059064 gnomAD-4.0.0 2.56292E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39404E-06 0 2.8456E-05
S/C 7202 Ig-56 66 rs747376234 0.1374 -0.026 0.921 N 0.313 0.252 0.358744678677 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 2.24165E-04 None 0 None 0 0 0
S/C 7202 Ig-56 66 rs747376234 0.1374 -0.026 0.921 N 0.313 0.252 0.358744678677 gnomAD-4.0.0 7.96257E-06 None None None None I None 0 0 None 0 1.38935E-04 None 0 0 0 0 0
S/P 7202 Ig-56 66 None 0.1421 None 0.002 N 0.226 0.142 0.141422826196 gnomAD-4.0.0 3.18488E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71942E-06 0 0
R/G 7295 Ig-57 66 rs752809738 0.0578 -0.13 None N 0.205 0.045 0.0401082797425 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 7295 Ig-57 66 rs752809738 0.0578 -0.13 None N 0.205 0.045 0.0401082797425 gnomAD-4.0.0 1.59175E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
R/I 7295 Ig-57 66 None 0.0991 None 0.033 N 0.505 0.053 0.0716867268079 gnomAD-4.0.0 1.59175E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
R/S 7295 Ig-57 66 rs1411254237 0.0938 0.121 0.003 N 0.231 0.035 0.0401082797425 gnomAD-2.1.1 6.37E-05 None None None None I None 2.29516E-04 0 None 0 0 None 0 None 0 0 0
R/S 7295 Ig-57 66 rs1411254237 0.0938 0.121 0.003 N 0.231 0.035 0.0401082797425 gnomAD-3.1.2 1.31E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 0 0 0
R/S 7295 Ig-57 66 rs1411254237 0.0938 0.121 0.003 N 0.231 0.035 0.0401082797425 gnomAD-4.0.0 3.09885E-06 None None None None I None 4.00481E-05 0 None 0 0 None 0 0 1.69539E-06 0 0
N/K 7388 Ig-58 66 None 0.1557 None 0.096 N 0.122 0.081 0.0482279557977 gnomAD-4.0.0 6.8448E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99675E-07 0 0
N/S 7388 Ig-58 66 rs1350328102 0.0517 0.488 None N 0.097 0.066 0.0297737177859 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
N/S 7388 Ig-58 66 rs1350328102 0.0517 0.488 None N 0.097 0.066 0.0297737177859 gnomAD-4.0.0 1.36894E-05 None None None None I None 5.97943E-05 0 None 0 0 None 0 0 1.52944E-05 0 1.65804E-05
S/I 7484 Ig-59 66 None 0.1315 None 0.965 N 0.361 0.548 0.726310685241 gnomAD-4.0.0 1.59273E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86074E-06 0 0
S/R 7484 Ig-59 66 None 0.2259 None 0.024 N 0.182 0.168 0.235664433957 gnomAD-4.0.0 1.59268E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86066E-06 0 0
G/R 7580 Ig-60 66 rs1215151938 0.6857 None 0.999 N 0.814 0.29 0.362758974969 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/R 7580 Ig-60 66 rs1215151938 0.6857 None 0.999 N 0.814 0.29 0.362758974969 gnomAD-4.0.0 2.02989E-06 None None None None N None 1.74685E-05 0 None 0 0 None 0 0 0 0 3.40298E-05
E/A 7674 Ig-61 67 None 0.1155 None 0.789 N 0.418 0.15 0.297375071883 gnomAD-4.0.0 1.59359E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43423E-05 0
E/D 7674 Ig-61 67 rs865791908 0.094 None 0.002 N 0.169 0.065 0.0846915920261 gnomAD-4.0.0 1.59352E-05 None None None None N None 0 0 None 0 0 None 0 2.41313E-03 0 0 0
S/F 7767 Ig-62 66 None 0.1837 None 0.171 N 0.405 0.209 0.406668915854 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85909E-06 0 0
S/A 7861 Ig-63 67 None 0.0616 None None N 0.109 0.076 0.0551355673512 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
S/P 8050 Ig-65 66 rs2077970288 0.1864 None 0.984 N 0.452 0.339 0.166414681773 gnomAD-4.0.0 3.42104E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69844E-06 0 3.31323E-05
L/I 8143 Ig-66 66 rs1274064527 0.0778 -0.016 0.007 N 0.193 0.028 0.104622674875 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
L/I 8143 Ig-66 66 rs1274064527 0.0778 -0.016 0.007 N 0.193 0.028 0.104622674875 gnomAD-4.0.0 1.36843E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79898E-06 0 0
E/K 8236 Ig-67 66 rs377762626 0.1177 0.7 0.505 N 0.46 0.214 None gnomAD-2.1.1 2.41E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 3.56E-05 0
E/K 8236 Ig-67 66 rs377762626 0.1177 0.7 0.505 N 0.46 0.214 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
E/K 8236 Ig-67 66 rs377762626 0.1177 0.7 0.505 N 0.46 0.214 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/K 8236 Ig-67 66 rs377762626 0.1177 0.7 0.505 N 0.46 0.214 None gnomAD-4.0.0 1.09475E-05 None None None None N None 0 0 None 0 0 None 0 0 1.07938E-05 4.63736E-05 0
S/G 8329 Ig-68 66 None 0.0824 None 0.008 N 0.089 0.191 0.15556083564 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
S/N 8329 Ig-68 66 None 0.1013 None 0.001 N 0.151 0.212 0.165133752707 gnomAD-4.0.0 4.78965E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29665E-06 0 0
S/N 8425 Ig-69 66 rs13390491 0.0878 0.138 0.154 D 0.16 0.129 None gnomAD-2.1.1 1.75539E-01 None None None None I None 1.64581E-01 1.73539E-01 None 1.21606E-01 4.29082E-01 None 2.21704E-01 None 9.41587E-02 1.4968E-01 1.61948E-01
S/N 8425 Ig-69 66 rs13390491 0.0878 0.138 0.154 D 0.16 0.129 None gnomAD-3.1.2 1.67878E-01 None None None None I None 1.65385E-01 1.71236E-01 4.71491E-01 1.25648E-01 4.32144E-01 None 9.87351E-02 1.20253E-01 1.53741E-01 2.23744E-01 1.66826E-01
S/N 8425 Ig-69 66 rs13390491 0.0878 0.138 0.154 D 0.16 0.129 None 1000 genomes 2.4381E-01 None None None None I None 1.936E-01 1.83E-01 None None 4.355E-01 1.571E-01 None None None 2.464E-01 None
S/N 8425 Ig-69 66 rs13390491 0.0878 0.138 0.154 D 0.16 0.129 None gnomAD-4.0.0 1.63811E-01 None None None None I None 1.65942E-01 1.73532E-01 None 1.23175E-01 4.42288E-01 None 9.42399E-02 1.94977E-01 1.5232E-01 2.19715E-01 1.70805E-01
E/D 8615 Ig-71 67 rs758944073 0.1057 0.148 0.001 N 0.147 0.139 0.0666544352282 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
E/D 8615 Ig-71 67 rs758944073 0.1057 0.148 0.001 N 0.147 0.139 0.0666544352282 gnomAD-4.0.0 6.84269E-07 None None None None N None 0 0 None 0 0 None 1.87308E-05 0 0 0 0
A/T 8708 Ig-72 66 rs2077272281 0.0695 None 0.001 N 0.199 0.119 0.130388298395 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 8708 Ig-72 66 rs2077272281 0.0695 None 0.001 N 0.199 0.119 0.130388298395 gnomAD-4.0.0 3.0988E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23852E-06 0 0
A/V 8708 Ig-72 66 rs770253655 0.0963 -0.033 0.185 N 0.299 0.165 0.266843984389 gnomAD-2.1.1 2.41E-05 None None None None N None 0 1.73832E-04 None 0 0 None 0 None 0 0 0
A/V 8708 Ig-72 66 rs770253655 0.0963 -0.033 0.185 N 0.299 0.165 0.266843984389 gnomAD-4.0.0 9.54934E-06 None None None None N None 0 1.37187E-04 None 0 0 None 0 0 0 0 0
A/D 8802 Ig-73 67 rs1292226345 0.1501 -0.737 0.013 N 0.337 0.096 0.258283824007 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/D 8802 Ig-73 67 rs1292226345 0.1501 -0.737 0.013 N 0.337 0.096 0.258283824007 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85853E-06 0 0
S/N 8895 Ig-74 66 rs752659193 0.0712 0.212 None N 0.053 0.06 0.0611884634855 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/N 8895 Ig-74 66 rs752659193 0.0712 0.212 None N 0.053 0.06 0.0611884634855 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 4.77555E-04
S/N 8895 Ig-74 66 rs752659193 0.0712 0.212 None N 0.053 0.06 0.0611884634855 gnomAD-4.0.0 6.81732E-06 None None None None N None 0 0 None 0 0 None 0 0 8.4768E-06 0 1.60143E-05
S/T 8895 Ig-74 66 rs752659193 0.0706 0.128 0.007 N 0.167 0.027 0.0666544352282 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/T 8895 Ig-74 66 rs752659193 0.0706 0.128 0.007 N 0.167 0.027 0.0666544352282 gnomAD-4.0.0 1.02644E-05 None None None None N None 0 0 None 0 0 None 0 0 1.25936E-05 1.15961E-05 0
S/L 8991 Ig-75 66 None 0.0928 None None N 0.158 0.188 0.318540980066 gnomAD-4.0.0 2.73697E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59796E-06 0 0
S/T 8991 Ig-75 66 rs1196970507 0.0683 0.126 None N 0.1 0.106 0.0401082797425 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/T 8991 Ig-75 66 rs1196970507 0.0683 0.126 None N 0.1 0.106 0.0401082797425 gnomAD-4.0.0 1.59139E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85842E-06 0 0
S/T 9084 Ig-76 66 rs761372985 0.0779 0.054 None N 0.095 0.077 0.0762999501168 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/T 9084 Ig-76 66 rs761372985 0.0779 0.054 None N 0.095 0.077 0.0762999501168 gnomAD-4.0.0 3.42109E-06 None None None None N None 0 6.71021E-05 None 0 0 None 0 0 8.99465E-07 0 1.65656E-05
E/G 9177 Ig-77 66 rs1296040087 0.1306 -0.495 0.722 N 0.433 0.172 0.299770980665 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/G 9177 Ig-77 66 rs1296040087 0.1306 -0.495 0.722 N 0.433 0.172 0.299770980665 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 9177 Ig-77 66 rs1296040087 0.1306 -0.495 0.722 N 0.433 0.172 0.299770980665 gnomAD-4.0.0 6.5716E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
E/K 9177 Ig-77 66 None 0.1385 None 0.722 N 0.483 0.212 0.234412748748 gnomAD-4.0.0 1.08029E-05 None None None None N None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
N/S 9270 Ig-78 66 rs763189626 0.0616 0.218 None N 0.108 0.102 None gnomAD-2.1.1 1.61E-05 None None None None I None 6.46E-05 0 None 0 0 None 3.27E-05 None 0 1.77E-05 0
N/S 9270 Ig-78 66 rs763189626 0.0616 0.218 None N 0.108 0.102 None gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 9270 Ig-78 66 rs763189626 0.0616 0.218 None N 0.108 0.102 None gnomAD-4.0.0 4.08994E-05 None None None None I None 1.33447E-05 0 None 0 0 None 0 0 5.0857E-05 3.29482E-05 3.20215E-05
S/C 9366 Ig-79 66 rs1577827132 0.221 None 0.002 None 0.193 0.268 0.27479166964 gnomAD-4.0.0 1.59117E-06 None None None None I None 5.65355E-05 0 None 0 0 None 0 0 0 0 0
S/R 9366 Ig-79 66 rs374930292 0.2588 0.205 None None 0.133 0.125 0.1749357433 gnomAD-2.1.1 8.04E-06 None None None None I None 1.29199E-04 0 None 0 0 None 0 None 0 0 0
S/R 9366 Ig-79 66 rs374930292 0.2588 0.205 None None 0.133 0.125 0.1749357433 gnomAD-3.1.2 6.57E-05 None None None None I None 2.41289E-04 0 0 0 0 None 0 0 0 0 0
S/R 9366 Ig-79 66 rs374930292 0.2588 0.205 None None 0.133 0.125 0.1749357433 gnomAD-4.0.0 8.67551E-06 None None None None I None 1.86871E-04 0 None 0 0 None 0 0 0 0 0
G/E 9462 Ig-80 66 rs866946485 0.225 -0.202 0.968 None 0.523 0.271 0.231231049324 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
G/V 9462 Ig-80 66 None 0.1791 None 0.938 None 0.559 0.248 0.344483371355 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/V 9462 Ig-80 66 None 0.1791 None 0.938 None 0.559 0.248 0.344483371355 gnomAD-4.0.0 6.57272E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
N/D 9559 Ig-81 67 None 0.0708 None None None 0.158 0.108 0.0401082797425 gnomAD-4.0.0 1.5911E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02371E-05
N/K 9559 Ig-81 67 None 0.1473 None 0.004 None 0.149 0.029 0.0138822411134 gnomAD-4.0.0 6.84181E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99447E-07 0 0
T/I 9764 Ig-83 67 None 0.8 None 0.994 None 0.417 0.326 0.259272394797 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/S 9764 Ig-83 67 None 0.3018 None 0.287 None 0.174 0.16 0.0611884634855 gnomAD-4.0.0 1.36834E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 1.6564E-05
K/E 9966 Ig-84 67 rs1222395628 0.107 None 0.001 None 0.107 0.102 0.0920862733494 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/I 9966 Ig-84 67 rs1400936440 0.3427 None 0.007 None 0.169 0.16 0.295974979623 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
K/I 9966 Ig-84 67 rs1400936440 0.3427 None 0.007 None 0.169 0.16 0.295974979623 gnomAD-4.0.0 6.81735E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47683E-06 0 1.60113E-05
K/R 9966 Ig-84 67 rs1400936440 0.0943 0.338 0.002 None 0.133 0.05 0.16115917748 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
K/R 9966 Ig-84 67 rs1400936440 0.0943 0.338 0.002 None 0.133 0.05 0.16115917748 gnomAD-4.0.0 6.84319E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1605E-05 0
D/N 10142 Ig-86 65 rs1577675584 0.2937 None 0.896 None 0.439 0.24 0.201204373187 gnomAD-4.0.0 2.73666E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99395E-07 0 4.96919E-05
D/Y 10142 Ig-86 65 None 0.7136 None 0.995 None 0.481 0.275 0.332133492242 gnomAD-4.0.0 2.05249E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69819E-06 0 0
S/P 13751 Ig-87 68 rs1327407922 0.3385 None 1.0 D 0.709 0.448 None gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/R 13845 Ig-88 66 None 0.1199 None 0.017 N 0.443 0.055 0.0551355673512 gnomAD-4.0.0 1.36887E-06 None None None None N None 0 0 None 0 2.52372E-05 None 0 0 8.99708E-07 0 0
E/D 13940 Ig-89 65 None 0.1169 None 0.002 N 0.18 0.058 0.119812018005 gnomAD-4.0.0 3.23387E-06 None None None None N None 0 0 None 0 0 None 0 0 5.80713E-06 0 0
E/Q 13940 Ig-89 65 rs1172846357 0.293 0.129 0.791 N 0.44 0.169 0.183819452728 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/Q 13940 Ig-89 65 rs1172846357 0.293 0.129 0.791 N 0.44 0.169 0.183819452728 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/Q 13940 Ig-89 65 rs1172846357 0.293 0.129 0.791 N 0.44 0.169 0.183819452728 gnomAD-4.0.0 5.61401E-06 None None None None N None 0 0 None 0 0 None 0 0 7.66605E-06 0 0
D/N 14029 Ig-90 65 rs794729426 0.4248 None 0.986 N 0.785 0.384 0.227934060464 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
D/N 14029 Ig-90 65 rs794729426 0.4248 None 0.986 N 0.785 0.384 0.227934060464 gnomAD-4.0.0 5.12963E-06 None None None None I None 0 5.09286E-05 None 0 0 None 0 0 2.39521E-06 0 0
D/V 14117 Ig-91 64 rs2060168886 0.4354 None 0.942 N 0.637 0.172 0.313818047136 gnomAD-4.0.0 1.23209E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61947E-05 0 0
D/H 14206 Ig-92 65 None 0.6308 None 1.0 D 0.613 0.455 0.28722502521 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 14206 Ig-92 65 rs1418013035 0.2594 0.09 1.0 N 0.593 0.392 0.304435445954 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
D/N 14206 Ig-92 65 rs1418013035 0.2594 0.09 1.0 N 0.593 0.392 0.304435445954 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 14206 Ig-92 65 rs1418013035 0.2594 0.09 1.0 N 0.593 0.392 0.304435445954 gnomAD-4.0.0 6.57566E-06 None None None None N None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
K/R 14294 Ig-93 64 None 0.0961 None 0.549 N 0.362 0.071 0.154104182512 gnomAD-4.0.0 3.18461E-06 None None None None N None 0 4.57561E-05 None 0 0 None 0 0 0 0 0
G/D 14383 Ig-94 65 rs765835336 0.0594 0.044 None N 0.073 0.084 0.136095386433 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/D 14383 Ig-94 65 rs765835336 0.0594 0.044 None N 0.073 0.084 0.136095386433 gnomAD-4.0.0 1.59254E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43324E-05 0
G/R 14383 Ig-94 65 None 0.2161 None 0.026 N 0.469 0.053 0.324986149311 gnomAD-4.0.0 1.59253E-06 None None None None N None 0 0 None 0 0 None 1.8831E-05 0 0 0 0
D/A 14561 Ig-96 65 None 0.208 None 1.0 D 0.67 0.673 0.621717555292 gnomAD-4.0.0 1.60532E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45518E-05 0
D/G 14561 Ig-96 65 None 0.1682 None 1.0 D 0.632 0.722 0.613699239204 gnomAD-4.0.0 1.60532E-06 None None None None N None 0 0 None 0 0 None 1.89243E-05 0 0 0 0
D/Y 14561 Ig-96 65 rs745655055 0.2499 -0.023 1.0 D 0.691 0.651 0.641141256235 gnomAD-2.1.1 7.4E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.62E-05 0
D/Y 14561 Ig-96 65 rs745655055 0.2499 -0.023 1.0 D 0.691 0.651 0.641141256235 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/Y 14561 Ig-96 65 rs745655055 0.2499 -0.023 1.0 D 0.691 0.651 0.641141256235 gnomAD-4.0.0 4.97547E-06 None None None None N None 0 0 None 0 0 None 0 0 6.79717E-06 0 0
S/L 14650 Ig-97 65 None 0.1166 None 0.801 N 0.379 0.173 0.3349148499 gnomAD-4.0.0 1.59224E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
E/G 14917 Ig-100 65 None 0.1834 None 0.822 N 0.483 0.243 0.20549828249 gnomAD-4.0.0 4.79232E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29927E-06 0 0
E/K 14917 Ig-100 65 None 0.1821 None 0.822 N 0.467 0.293 0.191931220699 gnomAD-4.0.0 2.05386E-06 None None None None N None 0 0 None 0 0 None 1.87329E-05 0 1.79978E-06 0 0
D/E 15006 Ig-101 65 rs962116921 0.1504 None 0.001 N 0.268 0.066 0.0611884634855 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 4.38597E-03 0 0 None 0 0 0 0 0
D/E 15006 Ig-101 65 rs962116921 0.1504 None 0.001 N 0.268 0.066 0.0611884634855 gnomAD-4.0.0 2.63193E-05 None None None None I None 0 0 None 0 0 None 0 0 0 0 0
D/Y 15006 Ig-101 65 rs557941825 0.3488 -0.074 0.859 D 0.6 0.274 0.402755899245 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.94477E-04 None 0 0 0 0 0
D/Y 15006 Ig-101 65 rs557941825 0.3488 -0.074 0.859 D 0.6 0.274 0.402755899245 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
D/Y 15006 Ig-101 65 rs557941825 0.3488 -0.074 0.859 D 0.6 0.274 0.402755899245 gnomAD-4.0.0 6.57488E-06 None None None None I None 0 0 None 0 1.94932E-04 None 0 0 0 0 0
E/K 15095 Ig-102 65 rs2154212024 0.1566 None 0.684 D 0.289 0.433 0.394536629495 gnomAD-4.0.0 1.59392E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
E/Q 15095 Ig-102 65 None 0.1479 None 0.815 D 0.323 0.413 0.399740851666 gnomAD-4.0.0 1.59392E-06 None None None None N None 0 0 None 0 0 None 0 2.41779E-04 0 0 0
Q/E 15184 Ig-103 65 rs374605722 0.0681 None 0.002 N 0.117 0.08 0.119812018005 gnomAD-4.0.0 1.59363E-06 None None None None N None 5.67279E-05 0 None 0 0 None 0 0 0 0 0
D/E 15272 Ig-104 65 rs540340364 0.1338 -0.103 0.007 N 0.183 0.083 0.0297737177859 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
D/E 15272 Ig-104 65 rs540340364 0.1338 -0.103 0.007 N 0.183 0.083 0.0297737177859 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
D/E 15272 Ig-104 65 rs540340364 0.1338 -0.103 0.007 N 0.183 0.083 0.0297737177859 gnomAD-4.0.0 1.59335E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86264E-06 0 0
D/G 15272 Ig-104 65 None 0.1158 None 0.001 N 0.135 0.148 0.146414634003 gnomAD-4.0.0 1.59333E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86261E-06 0 0
D/N 15272 Ig-104 65 rs559878591 0.0909 0.028 0.001 N 0.105 0.09 0.0954503805726 gnomAD-2.1.1 2.15E-05 None None None None N None 0 0 None 0 3.08801E-04 None 0 None 0 0 0
D/N 15272 Ig-104 65 rs559878591 0.0909 0.028 0.001 N 0.105 0.09 0.0954503805726 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 9.73141E-04 None 0 0 0 0 0
D/N 15272 Ig-104 65 rs559878591 0.0909 0.028 0.001 N 0.105 0.09 0.0954503805726 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
D/N 15272 Ig-104 65 rs559878591 0.0909 0.028 0.001 N 0.105 0.09 0.0954503805726 gnomAD-4.0.0 8.68073E-06 None None None None N None 0 6.67379E-05 None 0 2.23364E-04 None 0 0 0 0 0
D/N 15455 Ig-106 65 rs370813526 0.2267 0.112 0.83 D 0.65 0.481 None gnomAD-2.1.1 5.67E-05 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 1.16655E-04 0
D/N 15455 Ig-106 65 rs370813526 0.2267 0.112 0.83 D 0.65 0.481 None gnomAD-3.1.2 4.61E-05 None None None None N None 0 0 0 0 0 None 0 0 1.03108E-04 0 0
D/N 15455 Ig-106 65 rs370813526 0.2267 0.112 0.83 D 0.65 0.481 None gnomAD-4.0.0 9.11989E-05 None None None None N None 0 3.34303E-05 None 0 0 None 1.25063E-04 1.64853E-04 1.12825E-04 0 4.81108E-05
R/C 15544 Ig-107 65 rs748932192 0.4779 0.115 1.0 D 0.79 0.531 0.672978241467 gnomAD-2.1.1 4.44E-05 None None None None N None 1.94301E-04 0 None 0 0 None 1.30804E-04 None 0 3.57E-05 0
R/C 15544 Ig-107 65 rs748932192 0.4779 0.115 1.0 D 0.79 0.531 0.672978241467 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/C 15544 Ig-107 65 rs748932192 0.4779 0.115 1.0 D 0.79 0.531 0.672978241467 gnomAD-4.0.0 1.24062E-05 None None None None N None 2.6753E-05 0 None 0 0 None 0 0 7.63426E-06 8.79082E-05 1.60303E-05
R/H 15544 Ig-107 65 rs772760901 0.2905 -0.639 1.0 D 0.784 0.519 0.610312411291 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 5.6E-05 None 3.27E-05 None 0 2.68E-05 0
R/H 15544 Ig-107 65 rs772760901 0.2905 -0.639 1.0 D 0.784 0.519 0.610312411291 gnomAD-4.0.0 5.47836E-06 None None None None N None 0 0 None 0 7.57652E-05 None 0 0 3.60042E-06 1.1602E-05 0
R/L 15544 Ig-107 65 None 0.5162 None 1.0 D 0.631 0.565 0.670669281473 gnomAD-4.0.0 6.84795E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00105E-07 0 0
G/R 15630 Ig-108 63 None 0.1573 None 0.029 N 0.427 0.077 0.256283259241 gnomAD-4.0.0 1.59439E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86356E-06 0 0
S/I 16324 Ig-110 63 rs878948684 0.1795 0.109 0.976 D 0.385 0.305 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
S/I 16324 Ig-110 63 rs878948684 0.1795 0.109 0.976 D 0.385 0.305 None gnomAD-4.0.0 7.53197E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89869E-06 0 0
S/R 16324 Ig-110 63 rs774497699 0.6339 0.205 0.988 N 0.331 0.24 0.225902525712 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
S/R 16324 Ig-110 63 rs774497699 0.6339 0.205 0.988 N 0.331 0.24 0.225902525712 gnomAD-4.0.0 3.18801E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72492E-06 0 0
A/S 17020 Ig-111 66 rs1232414991 0.0866 -0.263 0.338 N 0.412 0.112 0.104622674875 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/S 17020 Ig-111 66 rs1232414991 0.0866 -0.263 0.338 N 0.412 0.112 0.104622674875 gnomAD-4.0.0 1.5933E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86241E-06 0 0
A/T 17020 Ig-111 66 None 0.086 None 0.031 N 0.226 0.165 0.115124310173 gnomAD-4.0.0 1.5933E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86241E-06 0 0
P/L 17342 Ig-112 92 None 0.1282 None None N 0.242 0.07 0.290222751274 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 18038 Ig-114 71 rs527887963 0.1227 None 0.012 N 0.127 0.024 0.0920862733494 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 1.09649E-03 0 0 None 0 0 0 0 0
E/K 18038 Ig-114 71 rs527887963 0.1227 None 0.012 N 0.127 0.024 0.0920862733494 gnomAD-4.0.0 6.58137E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 0
E/Q 18038 Ig-114 71 rs527887963 0.1065 0.219 0.001 N 0.167 0.026 0.0611884634855 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 2.23789E-04 None 0 None 0 0 0
E/Q 18038 Ig-114 71 rs527887963 0.1065 0.219 0.001 N 0.167 0.026 0.0611884634855 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.9478E-04 None 0 0 0 0 0
E/Q 18038 Ig-114 71 rs527887963 0.1065 0.219 0.001 N 0.167 0.026 0.0611884634855 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
E/Q 18038 Ig-114 71 rs527887963 0.1065 0.219 0.001 N 0.167 0.026 0.0611884634855 gnomAD-4.0.0 1.02648E-05 None None None None N None 0 0 None 0 1.94647E-04 None 0 0 0 0 0
S/C 18452 Ig-115 71 rs567515550 0.1065 -0.034 0.612 N 0.473 0.142 None gnomAD-2.1.1 1.23E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.7E-05 0
S/C 18452 Ig-115 71 rs567515550 0.1065 -0.034 0.612 N 0.473 0.142 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.36E-05 0 0
S/C 18452 Ig-115 71 rs567515550 0.1065 -0.034 0.612 N 0.473 0.142 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
S/C 18452 Ig-115 71 rs567515550 0.1065 -0.034 0.612 N 0.473 0.142 None gnomAD-4.0.0 1.42872E-05 None None None None N None 0 0 None 0 0 None 0 0 1.95149E-05 0 0
S/F 18452 Ig-115 71 None 0.1539 None 0.295 N 0.539 0.112 0.435479573448 gnomAD-4.0.0 6.86021E-07 None None None None N None 0 0 None 0 0 None 0 0 9.004E-07 0 0
S/P 18452 Ig-115 71 rs372541479 0.2174 -0.094 0.055 N 0.52 0.123 None gnomAD-2.1.1 9.05E-05 None None None None N None 1.03717E-03 0 None 0 0 None 0 None 0 0 0
S/P 18452 Ig-115 71 rs372541479 0.2174 -0.094 0.055 N 0.52 0.123 None gnomAD-3.1.2 2.36876E-04 None None None None N None 7.72723E-04 1.96773E-04 0 0 0 None 0 0 0 0 4.78469E-04
S/P 18452 Ig-115 71 rs372541479 0.2174 -0.094 0.055 N 0.52 0.123 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
S/P 18452 Ig-115 71 rs372541479 0.2174 -0.094 0.055 N 0.52 0.123 None gnomAD-4.0.0 3.72736E-05 None None None None N None 7.096E-04 5.04982E-05 None 0 0 None 0 0 0 0 6.42116E-05
S/T 18757 Ig-116 70 rs1280256540 0.0706 -0.013 None N 0.122 0.138 0.104622674875 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
S/T 18757 Ig-116 70 rs1280256540 0.0706 -0.013 None N 0.122 0.138 0.104622674875 gnomAD-4.0.0 1.59461E-06 None None None None N None 0 2.29001E-05 None 0 0 None 0 0 0 0 0
S/G 19156 Ig-117 62 None 0.0813 None 0.002 N 0.123 0.075 0.16115917748 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 19156 Ig-117 62 rs2052061972 0.2397 None 0.549 N 0.371 0.151 0.359763055319 gnomAD-4.0.0 1.59263E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86017E-06 0 0
A/G 20542 Ig-121 64 rs373529637 0.1123 -0.183 0.027 N 0.311 0.054 None gnomAD-2.1.1 1.61E-05 None None None None I None 2.58465E-04 0 None 0 0 None 0 None 0 0 0
A/G 20542 Ig-121 64 rs373529637 0.1123 -0.183 0.027 N 0.311 0.054 None gnomAD-3.1.2 7.24E-05 None None None None I None 2.65572E-04 0 0 0 0 None 0 0 0 0 0
A/G 20542 Ig-121 64 rs373529637 0.1123 -0.183 0.027 N 0.311 0.054 None gnomAD-4.0.0 9.29896E-06 None None None None I None 2.00363E-04 0 None 0 0 None 0 0 0 0 0
A/V 20542 Ig-121 64 rs373529637 0.1359 -0.072 0.062 N 0.286 0.1 0.201204373187 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/V 20542 Ig-121 64 rs373529637 0.1359 -0.072 0.062 N 0.286 0.1 0.201204373187 gnomAD-4.0.0 2.0533E-06 None None None None I None 0 6.71381E-05 None 0 0 None 0 0 0 0 0
D/E 21239 Ig-123 63 None 0.1108 None 0.619 N 0.268 0.069 0.204665344411 gnomAD-4.0.0 1.59406E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86148E-06 0 0
K/E 21532 Ig-124 64 rs794729477 0.1671 0.079 0.99 N 0.525 0.259 0.1749357433 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
K/E 21532 Ig-124 64 rs794729477 0.1671 0.079 0.99 N 0.525 0.259 0.1749357433 gnomAD-4.0.0 9.55338E-06 None None None None I None 0 0 None 0 0 None 0 0 1.7163E-05 0 0
K/R 21929 Ig-125 64 rs1465791266 0.0852 0.409 0.998 N 0.551 0.153 0.192905019026 gnomAD-2.1.1 4.07E-06 None None None None N None 6.52E-05 0 None 0 0 None 0 None 0 0 0
K/R 21929 Ig-125 64 rs1465791266 0.0852 0.409 0.998 N 0.551 0.153 0.192905019026 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
K/R 21929 Ig-125 64 rs1465791266 0.0852 0.409 0.998 N 0.551 0.153 0.192905019026 gnomAD-4.0.0 5.17072E-06 None None None None N None 6.79094E-05 0 None 0 0 None 0 0 0 0 0
Y/C 22327 Ig-126 63 rs757701692 0.3115 0.601 0.995 N 0.615 0.373 0.396494342077 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
Y/C 22327 Ig-126 63 rs757701692 0.3115 0.601 0.995 N 0.615 0.373 0.396494342077 gnomAD-4.0.0 1.59235E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86036E-06 0 0
Y/C 23408 Ig-129 64 None 0.226 None 0.99 N 0.445 0.337 0.414021929199 gnomAD-4.0.0 1.59164E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8593E-06 0 0
Y/H 23408 Ig-129 64 rs754261585 0.1504 0.796 0.81 N 0.465 0.227 0.204665344411 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
Y/H 23408 Ig-129 64 rs754261585 0.1504 0.796 0.81 N 0.465 0.227 0.204665344411 gnomAD-4.0.0 2.05284E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79916E-06 0 1.65678E-05
S/N 23699 Ig-130 63 None 0.0894 None 0.001 N 0.128 0.05 0.143124449307 gnomAD-4.0.0 1.3687E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.31422E-05
E/A 24781 Ig-133 66 None 0.1961 None 0.309 N 0.419 0.264 0.258283824007 gnomAD-4.0.0 1.59184E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85941E-06 0 0
E/D 24781 Ig-133 66 None 0.0798 None 0.001 N 0.176 0.071 0.104622674875 gnomAD-4.0.0 1.36864E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79917E-06 0 0
V/I 25177 Ig-134 67 rs552074847 0.0711 0.084 None N 0.242 0.062 None gnomAD-2.1.1 7.15E-06 None None None None I None 4.13E-05 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 25177 Ig-134 67 rs552074847 0.0711 0.084 None N 0.242 0.062 None gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 2.07383E-04 0
V/I 25177 Ig-134 67 rs552074847 0.0711 0.084 None N 0.242 0.062 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
V/I 25177 Ig-134 67 rs552074847 0.0711 0.084 None N 0.242 0.062 None gnomAD-4.0.0 3.0448E-06 None None None None I None 1.74386E-05 0 None 0 0 None 0 0 1.20498E-06 4.69969E-05 0
Y/F 25574 Ig-135 61 rs1199417769 0.0798 None 0.003 N 0.199 0.11 0.158396225186 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/F 25574 Ig-135 61 rs1199417769 0.0798 None 0.003 N 0.199 0.11 0.158396225186 gnomAD-4.0.0 6.57549E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47067E-05 0 0
Y/H 25574 Ig-135 61 rs3813245 0.1456 0.745 0.939 N 0.425 0.189 None gnomAD-2.1.1 2.57529E-02 None None None None N None 4.88047E-03 3.35432E-02 None 1.47401E-02 6.14306E-02 None 6.15546E-03 None 4.79353E-02 2.33229E-02 2.64863E-02
Y/H 25574 Ig-135 61 rs3813245 0.1456 0.745 0.939 N 0.425 0.189 None gnomAD-3.1.2 2.02286E-02 None None None None N None 4.51298E-03 2.18361E-02 3.07018E-02 1.90202E-02 6.11455E-02 None 4.4434E-02 6.32911E-03 2.3418E-02 8.2713E-03 1.95985E-02
Y/H 25574 Ig-135 61 rs3813245 0.1456 0.745 0.939 N 0.425 0.189 None 1000 genomes 2.23642E-02 None None None None N None 8E-04 2.45E-02 None None 6.05E-02 2.68E-02 None None None 6.1E-03 None
Y/H 25574 Ig-135 61 rs3813245 0.1456 0.745 0.939 N 0.425 0.189 None gnomAD-4.0.0 2.29074E-02 None None None None N None 4.30655E-03 2.93676E-02 None 1.49087E-02 6.32315E-02 None 4.76652E-02 9.74884E-03 2.24515E-02 6.86617E-03 2.17099E-02
D/G 25863 Ig-136 66 rs1171070025 0.1182 0.054 0.645 N 0.485 0.227 0.18995819373 gnomAD-4.0.0 1.59193E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
N/H 26656 Ig-138 63 rs1333413620 0.0876 -0.381 0.655 N 0.299 0.132 0.128392430309 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
N/H 26656 Ig-138 63 rs1333413620 0.0876 -0.381 0.655 N 0.299 0.132 0.128392430309 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.41E-05 0 0 0 0
N/H 26656 Ig-138 63 rs1333413620 0.0876 -0.381 0.655 N 0.299 0.132 0.128392430309 gnomAD-4.0.0 3.0987E-06 None None None None N None 0 0 None 0 0 None 7.80982E-05 0 0 0 0
N/Y 26656 Ig-138 63 rs1333413620 0.1106 -0.415 0.003 N 0.181 0.161 0.224531998449 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
N/Y 26656 Ig-138 63 rs1333413620 0.1106 -0.415 0.003 N 0.181 0.161 0.224531998449 gnomAD-4.0.0 1.36852E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79907E-06 0 0
D/Y 26945 Ig-139 66 None 0.2024 None 0.99 N 0.542 0.441 0.469578130381 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/I 27342 Ig-140 65 rs758305003 0.0889 0.069 0.012 N 0.3 0.099 0.195762928549 gnomAD-2.1.1 2.01E-05 None None None None I None 0 0 None 0 2.78272E-04 None 0 None 0 0 0
T/I 27342 Ig-140 65 rs758305003 0.0889 0.069 0.012 N 0.3 0.099 0.195762928549 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 3.86847E-04 None 0 0 0 0 0
T/I 27342 Ig-140 65 rs758305003 0.0889 0.069 0.012 N 0.3 0.099 0.195762928549 gnomAD-4.0.0 3.07474E-05 None None None None I None 0 0 None 0 5.33514E-04 None 0 0 2.39323E-06 0 2.84463E-05
T/N 27342 Ig-140 65 None 0.0803 None None N 0.122 0.088 None gnomAD-4.0.0 1.59125E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
F/I 27739 Ig-141 64 rs886042186 0.3417 -0.246 0.983 N 0.553 0.383 0.374076547971 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
F/I 27739 Ig-141 64 rs886042186 0.3417 -0.246 0.983 N 0.553 0.383 0.374076547971 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
F/I 27739 Ig-141 64 rs886042186 0.3417 -0.246 0.983 N 0.553 0.383 0.374076547971 gnomAD-4.0.0 7.43747E-06 None None None None I None 1.33515E-05 0 None 0 0 None 0 0 9.32423E-06 0 0
E/G 28028 Ig-142 66 None 0.1542 None 0.822 N 0.462 0.329 0.323886383625 gnomAD-4.0.0 5.47518E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19651E-06 0 0
R/Q 28423 Ig-143 66 rs747851682 0.0949 0.311 0.989 N 0.417 0.188 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 5.6E-05 None 3.27E-05 None 0 8.89E-06 0
R/Q 28423 Ig-143 66 rs747851682 0.0949 0.311 0.989 N 0.417 0.188 None gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 28423 Ig-143 66 rs747851682 0.0949 0.311 0.989 N 0.417 0.188 None gnomAD-4.0.0 8.67662E-06 None None None None N None 4.00534E-05 0 None 0 0 None 0 0 6.78076E-06 3.29424E-05 0
N/H 28818 Ig-144 64 rs1481995355 0.0832 -0.531 0.484 N 0.357 0.098 0.151104730317 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.35E-05 None 0 0 0
N/H 28818 Ig-144 64 rs1481995355 0.0832 -0.531 0.484 N 0.357 0.098 0.151104730317 gnomAD-4.0.0 1.59839E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44475E-05 0
N/S 28818 Ig-144 64 rs749233410 0.0809 0.316 None N 0.158 0.19 0.0482279557977 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
N/S 28818 Ig-144 64 rs749233410 0.0809 0.316 None N 0.158 0.19 0.0482279557977 gnomAD-4.0.0 1.59809E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44434E-05 0
A/T 29110 Ig-145 66 rs1462899266 0.0701 -0.45 None N 0.338 0.023 0.0716867268079 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/T 29110 Ig-145 66 rs1462899266 0.0701 -0.45 None N 0.338 0.023 0.0716867268079 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 29110 Ig-145 66 rs1462899266 0.0701 -0.45 None N 0.338 0.023 0.0716867268079 gnomAD-4.0.0 1.79698E-05 None None None None N None 0 0 None 0 0 None 0 0 2.37313E-05 0 1.60092E-05
A/V 29110 Ig-145 66 rs763682832 0.0986 -0.161 0.062 N 0.343 0.038 0.258283824007 gnomAD-2.1.1 3.62E-05 None None None None N None 0 0 None 0 0 None 2.94098E-04 None 0 0 0
A/V 29110 Ig-145 66 rs763682832 0.0986 -0.161 0.062 N 0.343 0.038 0.258283824007 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 4.77555E-04
A/V 29110 Ig-145 66 rs763682832 0.0986 -0.161 0.062 N 0.343 0.038 0.258283824007 gnomAD-4.0.0 2.54039E-05 None None None None N None 0 0 None 0 0 None 0 0 8.47555E-07 4.28176E-04 1.60036E-05
L/F 29506 Ig-146 63 None 0.0865 None 0.982 N 0.545 0.142 0.329020015101 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 8.99437E-07 0 0
N/S 29905 Ig-147 64 rs773727575 0.0791 0.386 0.052 N 0.268 0.116 0.0762999501168 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/S 29905 Ig-147 64 rs773727575 0.0791 0.386 0.052 N 0.268 0.116 0.0762999501168 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 29905 Ig-147 64 rs773727575 0.0791 0.386 0.052 N 0.268 0.116 0.0762999501168 gnomAD-4.0.0 5.12376E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39273E-06 4.02015E-05 0
E/G 30197 Ig-148 66 rs531923761 0.1878 -0.518 0.993 N 0.65 0.432 0.32082282376 gnomAD-2.1.1 3.24E-05 None None None None N None 0 0 None 0 0 None 2.33707E-04 None 0 0 1.67504E-04
E/G 30197 Ig-148 66 rs531923761 0.1878 -0.518 0.993 N 0.65 0.432 0.32082282376 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
E/G 30197 Ig-148 66 rs531923761 0.1878 -0.518 0.993 N 0.65 0.432 0.32082282376 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/G 30197 Ig-148 66 rs531923761 0.1878 -0.518 0.993 N 0.65 0.432 0.32082282376 gnomAD-4.0.0 1.02693E-05 None None None None N None 0 0 None 0 0 None 0 0 0 9.44644E-05 2.84722E-05
D/G 30592 Ig-149 61 None 0.1818 None 0.22 N 0.439 0.192 0.110078149338 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
D/N 30592 Ig-149 61 rs767435344 0.1065 0.539 0.002 N 0.197 0.193 0.0846915920261 gnomAD-2.1.1 1.16561E-04 None None None None I None 0 0 None 0 0 None 9.47836E-04 None 0 0 0
D/N 30592 Ig-149 61 rs767435344 0.1065 0.539 0.002 N 0.197 0.193 0.0846915920261 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 0 6.22148E-04 0
D/N 30592 Ig-149 61 rs767435344 0.1065 0.539 0.002 N 0.197 0.193 0.0846915920261 gnomAD-4.0.0 5.08154E-05 None None None None I None 0 0 None 0 0 None 0 0 8.47621E-07 8.56465E-04 4.80323E-05
N/I 30989 Ig-150 63 rs755136924 0.1665 0.356 0.188 N 0.312 0.116 0.344483371355 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
N/I 30989 Ig-150 63 rs755136924 0.1665 0.356 0.188 N 0.312 0.116 0.344483371355 gnomAD-3.1.2 1.31E-05 None None None None I None 0 1.30976E-04 0 0 0 None 0 0 0 0 0
N/I 30989 Ig-150 63 rs755136924 0.1665 0.356 0.188 N 0.312 0.116 0.344483371355 gnomAD-4.0.0 1.31415E-05 None None None None I None 0 1.30976E-04 None 0 0 None 0 0 0 0 0
N/S 30989 Ig-150 63 rs755136924 0.0769 0.517 0.027 N 0.305 0.1 0.0482279557977 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
N/S 30989 Ig-150 63 rs755136924 0.0769 0.517 0.027 N 0.305 0.1 0.0482279557977 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 30989 Ig-150 63 rs755136924 0.0769 0.517 0.027 N 0.305 0.1 0.0482279557977 gnomAD-4.0.0 4.33765E-06 None None None None I None 1.33451E-05 0 None 0 0 None 0 0 4.23799E-06 0 1.60113E-05
G/A 31281 Ig-151 64 None 0.1559 None 0.992 N 0.509 0.337 0.130388298395 gnomAD-4.0.0 6.84168E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
G/D 31281 Ig-151 64 None 0.4098 None 0.999 N 0.757 0.437 0.156986980423 gnomAD-4.0.0 3.42084E-06 None None None None N None 0 0 None 0 5.03981E-05 None 0 0 1.79884E-06 1.15931E-05 0
G/S 31281 Ig-151 64 rs1352252944 0.132 -0.013 0.905 N 0.434 0.176 0.0846915920261 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/S 31281 Ig-151 64 rs1352252944 0.132 -0.013 0.905 N 0.434 0.176 0.0846915920261 gnomAD-4.0.0 1.59106E-06 None None None None N None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
S/N 31681 Ig-152 61 rs780124773 0.0809 0.345 0.004 N 0.164 0.05 0.0401082797425 gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.12E-05 0
S/N 31681 Ig-152 61 rs780124773 0.0809 0.345 0.004 N 0.164 0.05 0.0401082797425 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 31681 Ig-152 61 rs780124773 0.0809 0.345 0.004 N 0.164 0.05 0.0401082797425 gnomAD-4.0.0 1.05345E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44095E-05 0 0
Y/C 32078 Ig-153 62 rs1157695554 0.2365 0.491 1.0 N 0.683 0.577 0.462287137294 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
Y/C 32078 Ig-153 62 rs1157695554 0.2365 0.491 1.0 N 0.683 0.577 0.462287137294 gnomAD-4.0.0 1.59147E-05 None None None None I None 0 0 None 0 2.773E-04 None 0 0 0 0 0
Y/S 32078 Ig-153 62 rs1157695554 0.2425 -0.149 1.0 N 0.663 0.505 0.520535218364 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
R/G 32372 Ig-154 66 rs1298215224 0.1299 -0.437 0.024 N 0.215 0.076 0.254761474806 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
R/G 32372 Ig-154 66 rs1298215224 0.1299 -0.437 0.024 N 0.215 0.076 0.254761474806 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/G 32372 Ig-154 66 rs1298215224 0.1299 -0.437 0.024 N 0.215 0.076 0.254761474806 gnomAD-4.0.0 5.07563E-06 None None None None I None 1.74697E-05 0 None 0 0 None 0 0 4.82083E-06 0 0
G/V 32768 Ig-155 61 None 0.0888 None 0.055 N 0.425 0.094 0.223146558224 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 33166 Ig-156 66 None 0.3615 None 0.998 N 0.617 0.458 0.351830644314 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85824E-06 0 0
T/P 33263 Ig-157 61 None 0.2823 None 0.952 N 0.493 0.261 0.387366425376 gnomAD-4.0.0 4.78444E-06 None None None None N None 0 0 None 0 0 None 0 0 8.59476E-06 0 0
T/S 33263 Ig-157 61 rs369648529 0.1135 -0.57 0.034 N 0.321 0.152 0.195762928549 gnomAD-2.1.1 1.22E-05 None None None None N None 6.53E-05 2.92E-05 None 0 0 None 0 None 0 8.96E-06 0
T/S 33263 Ig-157 61 rs369648529 0.1135 -0.57 0.034 N 0.321 0.152 0.195762928549 gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 33263 Ig-157 61 rs369648529 0.1135 -0.57 0.034 N 0.321 0.152 0.195762928549 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/S 33263 Ig-157 61 rs369648529 0.1135 -0.57 0.034 N 0.321 0.152 0.195762928549 gnomAD-4.0.0 6.41634E-06 None None None None N None 5.06808E-05 1.69727E-05 None 0 0 None 0 0 2.39773E-06 0 0
D/G 33563 Ig-158 68 rs1691369935 0.2285 None 0.637 N 0.384 0.342 0.29527378943 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 33563 Ig-158 68 rs1691369935 0.2285 None 0.637 N 0.384 0.342 0.29527378943 gnomAD-4.0.0 6.5722E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
D/N 33563 Ig-158 68 rs746118157 0.1122 0.759 0.006 N 0.184 0.234 0.212008924253 gnomAD-2.1.1 4.14E-06 None None None None N None 0 2.94E-05 None 0 0 None 0 None 0 0 0
D/N 33563 Ig-158 68 rs746118157 0.1122 0.759 0.006 N 0.184 0.234 0.212008924253 gnomAD-4.0.0 3.25247E-06 None None None None N None 0 2.31664E-05 None 0 0 None 0 0 2.93071E-06 0 0
D/N 34326 Ig-161 69 rs1227502652 0.0913 None 0.004 N 0.224 0.127 0.134241683229 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 34326 Ig-161 69 rs1227502652 0.0913 None 0.004 N 0.224 0.127 0.134241683229 gnomAD-4.0.0 6.56935E-06 None None None None N None 2.41208E-05 0 None 0 0 None 0 0 0 0 0
D/Y 35007 Ig-163 66 None 0.2646 None 0.741 N 0.391 0.305 0.370051654043 gnomAD-4.0.0 1.5909E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
S/T 35194 Ig-164 66 rs1269069525 0.0897 -0.66 0.722 N 0.425 0.163 0.187945064343 gnomAD-2.1.1 4.01E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
S/T 35194 Ig-164 66 rs1269069525 0.0897 -0.66 0.722 N 0.425 0.163 0.187945064343 gnomAD-4.0.0 1.59088E-06 None None None None N None 5.65227E-05 0 None 0 0 None 0 0 0 0 0
S/C 35352 Ig-165 67 rs746512551 0.1731 0.093 0.928 N 0.254 0.242 None gnomAD-2.1.1 7.13E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
S/C 35352 Ig-165 67 rs746512551 0.1731 0.093 0.928 N 0.254 0.242 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/C 35352 Ig-165 67 rs746512551 0.1731 0.093 0.928 N 0.254 0.242 None gnomAD-4.0.0 3.8424E-06 None None None None N None 5.07271E-05 0 None 0 0 None 0 0 0 0 0
S/P 35352 Ig-165 67 rs370094513 0.3731 None 0.773 N 0.299 0.219 None gnomAD-2.1.1 3.19E-05 None None None None N None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
S/P 35352 Ig-165 67 rs370094513 0.3731 None 0.773 N 0.299 0.219 None gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
S/P 35352 Ig-165 67 rs370094513 0.3731 None 0.773 N 0.299 0.219 None gnomAD-4.0.0 5.12317E-06 None None None None N None 5.07271E-05 0 None 0 0 None 0 0 2.39245E-06 0 0
S/Y 35352 Ig-165 67 rs746512551 0.1977 -0.636 0.912 N 0.283 0.182 0.331365685468 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
S/Y 35352 Ig-165 67 rs746512551 0.1977 -0.636 0.912 N 0.283 0.182 0.331365685468 gnomAD-4.0.0 4.77271E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57256E-06 0 0
S/T 35485 Ig-166 66 None 0.0841 None 0.979 N 0.395 0.178 0.130388298395 gnomAD-4.0.0 1.20038E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31256E-06 0 0
R/G 35670 Ig-167 64 None 0.1347 None 0.024 N 0.368 0.066 0.273503213844 gnomAD-4.0.0 1.59281E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4339E-05 0
R/T 35670 Ig-167 64 rs534961012 0.1263 0.228 0.055 N 0.397 0.064 None gnomAD-2.1.1 3.58E-05 None None None None I None 3.31318E-04 0 None 0 0 None 3.28E-05 None 0 0 1.40885E-04
R/T 35670 Ig-167 64 rs534961012 0.1263 0.228 0.055 N 0.397 0.064 None gnomAD-3.1.2 3.94E-05 None None None None I None 1.44823E-04 0 0 0 0 None 0 0 0 0 0
R/T 35670 Ig-167 64 rs534961012 0.1263 0.228 0.055 N 0.397 0.064 None 1000 genomes 3.99361E-04 None None None None I None 1.5E-03 0 None None 0 0 None None None 0 None
R/T 35670 Ig-167 64 rs534961012 0.1263 0.228 0.055 N 0.397 0.064 None gnomAD-4.0.0 3.34728E-05 None None None None I None 5.06478E-04 0 None 0 0 None 0 0 0 3.29547E-05 2.0814E-04
Q/R 35964 Ig-169 68 None 0.1218 None 0.042 N 0.204 0.102 0.0716867268079 gnomAD-4.0.0 2.05245E-06 None None None -0.48(OBSL1) -0.448(OBSCN) N None 0 0 None 0 0 None 0 0 2.69821E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.