Structural position:

  • Domain Type: Ig
  • Aligned Position: 149
  • Secondary Structure Element: h
  • Secondary Structure Region: ⍺-helix

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
N/K 74 Ig-1 69 rs2094104209 0.7122 None 0.934 N 0.667 0.387 0.232513804876 gnomAD-4.0.0 1.20032E-06 None None None -0.976(TCAP) N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
N/S 74 Ig-1 69 rs774795341 0.1089 -0.96 0.488 N 0.642 0.292 0.216624796971 gnomAD-2.1.1 3.98E-06 None None None -0.682(TCAP) N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
N/S 74 Ig-1 69 rs774795341 0.1089 -0.96 0.488 N 0.642 0.292 0.216624796971 gnomAD-4.0.0 8.20886E-06 None None None -0.682(TCAP) N None 0 0 None 0 0 None 0 0 1.07918E-05 0 0
D/G 170 Ig-2 67 None 0.9946 None 0.998 D 0.733 0.865 0.685291068997 gnomAD-4.0.0 2.40075E-06 None None None -0.701(TCAP) N None 0 0 None 0 0 None 0 0 2.62513E-06 0 0
D/E 1009 Ig-3 67 rs794729523 0.9966 None 1.0 D 0.583 0.529 0.669326051152 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/E 1009 Ig-3 67 rs794729523 0.9966 None 1.0 D 0.583 0.529 0.669326051152 gnomAD-4.0.0 7.43529E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47472E-06 0 3.20123E-05
D/G 1150 Ig-4 69 None 0.9968 None 1.0 D 0.824 0.935 0.695812936145 gnomAD-4.0.0 1.59076E-06 None None None None N None 0 0 None 0 0 None 1.88225E-05 0 0 0 0
D/N 1150 Ig-4 69 rs879038939 0.9779 -0.143 1.0 D 0.804 0.768 0.655467273365 gnomAD-2.1.1 7.96E-06 None None None None N None 1.23047E-04 0 None 0 0 None 0 None 0 0 0
D/N 1150 Ig-4 69 rs879038939 0.9779 -0.143 1.0 D 0.804 0.768 0.655467273365 gnomAD-4.0.0 2.05235E-06 None None None None N None 5.97443E-05 0 None 0 0 None 0 0 8.99327E-07 0 0
D/Y 1150 Ig-4 69 rs879038939 0.9949 1.447 1.0 D 0.91 0.888 None gnomAD-2.1.1 7.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.55E-05 0
D/Y 1150 Ig-4 69 rs879038939 0.9949 1.447 1.0 D 0.91 0.888 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/Y 1150 Ig-4 69 rs879038939 0.9949 1.447 1.0 D 0.91 0.888 None gnomAD-4.0.0 3.71759E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08481E-06 0 0
D/Y 1358 Ig-5 68 rs373988162 0.9909 1.829 0.999 D 0.858 0.813 None gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.84E-06 0
D/Y 1358 Ig-5 68 rs373988162 0.9909 1.829 0.999 D 0.858 0.813 None gnomAD-3.1.2 1.98E-05 None None None None N None 0 0 0 0 0 None 0 0 4.43E-05 0 0
D/Y 1358 Ig-5 68 rs373988162 0.9909 1.829 0.999 D 0.858 0.813 None gnomAD-4.0.0 1.61177E-05 None None None None N None 0 0 None 0 0 None 0 0 2.0344E-05 0 3.20164E-05
D/G 1524 Ig-6 68 rs1244905909 0.9149 -0.864 1.0 D 0.767 0.902 0.730117484633 gnomAD-2.1.1 7.98E-06 None None None None N None 0 0 None 0 1.0929E-04 None 0 None 0 0 0
D/G 1524 Ig-6 68 rs1244905909 0.9149 -0.864 1.0 D 0.767 0.902 0.730117484633 gnomAD-4.0.0 9.54596E-06 None None None None N None 0 0 None 0 1.6663E-04 None 0 0 0 0 0
D/N 1624 Ig-7 69 None 0.7808 None 1.0 D 0.785 0.751 0.608268572844 gnomAD-4.0.0 1.59081E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8566E-06 0 0
D/V 1624 Ig-7 69 rs1290278898 0.9688 1.05 1.0 D 0.872 0.936 0.91714051448 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
D/V 1624 Ig-7 69 rs1290278898 0.9688 1.05 1.0 D 0.872 0.936 0.91714051448 gnomAD-4.0.0 1.36823E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79861E-06 0 0
D/V 1906 Ig-9 66 rs1490334415 0.9987 0.954 1.0 D 0.849 0.907 0.809660090653 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
D/V 1906 Ig-9 66 rs1490334415 0.9987 0.954 1.0 D 0.849 0.907 0.809660090653 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
D/Y 1906 Ig-9 66 rs1194783923 0.9974 0.602 1.0 D 0.857 0.878 0.83116692961 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
D/Y 1906 Ig-9 66 rs1194783923 0.9974 0.602 1.0 D 0.857 0.878 0.83116692961 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
D/N 2145 Ig-10 68 None 0.8674 None 1.0 D 0.78 0.838 0.634202473982 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 2240 Ig-11 67 rs149404931 0.747 -0.512 1.0 D 0.597 0.545 0.516827169674 gnomAD-2.1.1 1.42E-05 None None None None N None 1.60205E-04 0 None 0 0 None 0 None 0 0 0
D/E 2240 Ig-11 67 rs149404931 0.747 -0.512 1.0 D 0.597 0.545 0.516827169674 gnomAD-3.1.2 3.94E-05 None None None None N None 1.44669E-04 0 0 0 0 None 0 0 0 0 0
D/E 2240 Ig-11 67 rs149404931 0.747 -0.512 1.0 D 0.597 0.545 0.516827169674 gnomAD-4.0.0 3.94151E-05 None None None None N None 1.44669E-04 0 None 0 0 None 0 0 0 0 0
D/G 2240 Ig-11 67 rs745532581 0.8513 -0.056 1.0 D 0.781 0.879 0.70718994021 gnomAD-2.1.1 7.08E-06 None None None None N None 0 0 None 0 1.00462E-04 None 0 None 0 0 0
D/G 2240 Ig-11 67 rs745532581 0.8513 -0.056 1.0 D 0.781 0.879 0.70718994021 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92753E-04 None 0 0 0 0 0
D/G 2240 Ig-11 67 rs745532581 0.8513 -0.056 1.0 D 0.781 0.879 0.70718994021 gnomAD-4.0.0 1.85904E-06 None None None None N None 0 0 None 0 6.69225E-05 None 0 0 0 0 0
D/N 2240 Ig-11 67 rs769846959 0.455 -0.533 1.0 D 0.768 0.706 0.675068926283 gnomAD-2.1.1 2.83E-05 None None None None N None 0 0 None 0 0 None 0 None 3.18725E-04 0 0
D/N 2240 Ig-11 67 rs769846959 0.455 -0.533 1.0 D 0.768 0.706 0.675068926283 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 1.88288E-04 0 0 0 0
D/N 2240 Ig-11 67 rs769846959 0.455 -0.533 1.0 D 0.768 0.706 0.675068926283 gnomAD-4.0.0 2.43354E-05 None None None None N None 0 0 None 0 0 None 2.98086E-04 0 0 0 0
D/G 2332 Ig-12 66 rs749655939 0.9314 -0.473 1.0 D 0.785 0.902 0.729455935219 gnomAD-2.1.1 1.42E-05 None None None None N None 8.01E-05 0 None 0 0 None 0 None 0 1.55E-05 0
D/G 2332 Ig-12 66 rs749655939 0.9314 -0.473 1.0 D 0.785 0.902 0.729455935219 gnomAD-4.0.0 6.1567E-06 None None None None N None 5.97479E-05 0 None 0 0 None 0 0 6.29517E-06 0 0
D/N 2332 Ig-12 66 rs771180382 0.6529 -0.892 1.0 D 0.779 0.837 0.738802388025 gnomAD-2.1.1 1.2E-05 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 8.82E-06 0
D/N 2332 Ig-12 66 rs771180382 0.6529 -0.892 1.0 D 0.779 0.837 0.738802388025 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/N 2332 Ig-12 66 rs771180382 0.6529 -0.892 1.0 D 0.779 0.837 0.738802388025 gnomAD-4.0.0 7.68433E-06 None None None None N None 0 6.78081E-05 None 0 0 None 0 0 4.78361E-06 0 0
D/Y 2332 Ig-12 66 rs771180382 0.8922 0.42 1.0 D 0.851 0.906 0.911509777594 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/Y 2332 Ig-12 66 rs771180382 0.8922 0.42 1.0 D 0.851 0.906 0.911509777594 gnomAD-4.0.0 1.59057E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
D/G 2421 Ig-13 66 rs1181070487 0.9604 -1.12 1.0 D 0.768 0.962 0.718170957977 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
D/G 2421 Ig-13 66 rs1181070487 0.9604 -1.12 1.0 D 0.768 0.962 0.718170957977 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/G 2421 Ig-13 66 rs1181070487 0.9604 -1.12 1.0 D 0.768 0.962 0.718170957977 gnomAD-4.0.0 2.02981E-06 None None None None N None 1.74685E-05 0 None 0 0 None 0 0 1.20492E-06 0 0
D/V 2598 Ig-15 66 None 0.8111 None 0.984 D 0.833 0.874 0.805222711834 gnomAD-4.0.0 8.4028E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18809E-06 0 0
D/H 2685 Ig-16 65 None 0.6164 None 1.0 D 0.795 0.613 0.738525484636 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 2685 Ig-16 65 None 0.6164 None 1.0 D 0.795 0.613 0.738525484636 gnomAD-4.0.0 6.57194E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46964E-05 0 0
D/E 2773 Ig-17 67 rs1364502747 0.8249 -0.559 1.0 D 0.559 0.739 0.506006782367 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/E 2773 Ig-17 67 rs1364502747 0.8249 -0.559 1.0 D 0.559 0.739 0.506006782367 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 2773 Ig-17 67 rs1364502747 0.8249 -0.559 1.0 D 0.559 0.739 0.506006782367 gnomAD-4.0.0 6.56953E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46959E-05 0 0
D/G 2773 Ig-17 67 None 0.9483 None 1.0 D 0.767 0.931 0.65076212359 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 2773 Ig-17 67 rs1455641988 0.7868 -0.933 1.0 D 0.774 0.67 0.612615269616 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 1.63185E-04
D/N 2773 Ig-17 67 rs1455641988 0.7868 -0.933 1.0 D 0.774 0.67 0.612615269616 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/N 2773 Ig-17 67 rs1455641988 0.7868 -0.933 1.0 D 0.774 0.67 0.612615269616 gnomAD-4.0.0 6.40279E-06 None None None None N None 0 1.6948E-05 None 0 0 None 0 2.24014E-04 0 0 8.52563E-05
D/H 2860 Ig-18 66 rs2091257509 0.7958 None 0.994 D 0.801 0.559 0.663786076597 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 4.78927E-04
D/H 2860 Ig-18 66 rs2091257509 0.7958 None 0.994 D 0.801 0.559 0.663786076597 gnomAD-4.0.0 3.04486E-06 None None None None N None 0 6.15082E-05 None 0 0 None 0 0 1.20494E-06 0 3.40298E-05
D/V 3034 Ig-20 66 None 0.9893 None 0.994 D 0.883 0.874 0.843089832369 gnomAD-4.0.0 3.18129E-06 None None None None N None 0 0 None 0 0 None 3.7635E-05 0 0 0 0
D/E 3123 Ig-21 66 rs397517785 0.9513 -0.5 1.0 D 0.589 0.59 0.471052466308 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 1.63345E-04
D/E 3123 Ig-21 66 rs397517785 0.9513 -0.5 1.0 D 0.589 0.59 0.471052466308 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
D/E 3123 Ig-21 66 rs397517785 0.9513 -0.5 1.0 D 0.589 0.59 0.471052466308 gnomAD-4.0.0 1.02445E-05 None None None None N None 0 0 None 0 0 None 0 0 0 9.37961E-05 2.8422E-05
D/N 3123 Ig-21 66 rs1213706471 0.9419 -0.638 1.0 D 0.764 0.654 0.633120732306 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
D/N 3123 Ig-21 66 rs1213706471 0.9419 -0.638 1.0 D 0.764 0.654 0.633120732306 gnomAD-4.0.0 1.59056E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85652E-06 0 0
D/E 3214 Ig-22 68 rs368323634 0.966 -0.632 1.0 D 0.585 0.63 0.512942373286 gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
D/E 3214 Ig-22 68 rs368323634 0.966 -0.632 1.0 D 0.585 0.63 0.512942373286 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 0 1.47E-05 0 0
D/E 3214 Ig-22 68 rs368323634 0.966 -0.632 1.0 D 0.585 0.63 0.512942373286 gnomAD-4.0.0 1.05323E-05 None None None None N None 0 1.66661E-05 None 0 0 None 0 0 1.27116E-05 0 1.60041E-05
D/N 3214 Ig-22 68 rs778326573 0.9621 -0.939 1.0 D 0.805 0.757 0.63923631105 gnomAD-2.1.1 1.42E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.33E-05 1.38581E-04
D/N 3214 Ig-22 68 rs778326573 0.9621 -0.939 1.0 D 0.805 0.757 0.63923631105 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 4.77555E-04
D/N 3214 Ig-22 68 rs778326573 0.9621 -0.939 1.0 D 0.805 0.757 0.63923631105 gnomAD-4.0.0 6.19574E-06 None None None None N None 0 0 None 0 0 None 0 0 6.77962E-06 1.09791E-05 1.60036E-05
D/G 3305 Ig-23 67 None 0.9883 None 1.0 D 0.779 0.899 0.666850800596 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
D/H 3305 Ig-23 67 None 0.9859 None 1.0 D 0.836 0.829 0.639199560535 gnomAD-4.0.0 6.84078E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
D/N 3305 Ig-23 67 rs746334195 0.9249 -0.613 1.0 D 0.773 0.794 0.597400496174 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
D/N 3305 Ig-23 67 rs746334195 0.9249 -0.613 1.0 D 0.773 0.794 0.597400496174 gnomAD-4.0.0 6.84078E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
D/Y 3305 Ig-23 67 rs746334195 0.9717 1.216 1.0 D 0.863 0.872 0.861210064198 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
D/Y 3305 Ig-23 67 rs746334195 0.9717 1.216 1.0 D 0.863 0.872 0.861210064198 gnomAD-4.0.0 6.84078E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
D/N 3410 Ig-24 66 None 0.7248 None 1.0 D 0.78 0.715 0.674262823506 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/V 3410 Ig-24 66 rs1436088108 0.9418 None 1.0 D 0.847 0.937 0.912779747741 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 3410 Ig-24 66 rs1436088108 0.9418 None 1.0 D 0.847 0.937 0.912779747741 gnomAD-4.0.0 6.5697E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46972E-05 0 0
H/P 3533 Ig-25 69 None 0.8435 None None None None 0.302 None gnomAD-4.0.0 1.59176E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85954E-06 0 0
H/Q 3533 Ig-25 69 rs1351766559 0.5452 None None None None 0.216 None gnomAD-4.0.0 1.59185E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85974E-06 0 0
D/A 3726 Ig-26 67 None 0.9291 None None None None 0.459 None gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
D/G 3726 Ig-26 67 rs548947930 0.9009 None None None None 0.378 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/G 3726 Ig-26 67 rs548947930 0.9009 None None None None 0.378 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 3726 Ig-26 67 rs548947930 0.9009 None None None None 0.378 None gnomAD-4.0.0 5.12361E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57144E-06 0 0
D/V 3726 Ig-26 67 rs548947930 0.945 0.721 None None None 0.651 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/V 3726 Ig-26 67 rs548947930 0.945 0.721 None None None 0.651 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/V 3726 Ig-26 67 rs548947930 0.945 0.721 None None None 0.651 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
D/V 3726 Ig-26 67 rs548947930 0.945 0.721 None None None 0.651 None gnomAD-4.0.0 6.56366E-06 None None None None N None 2.40419E-05 0 None 0 0 None 0 0 0 0 0
D/E 3886 Ig-27 67 rs1300492136 0.6896 0.622 0.027 D 0.611 0.527 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
D/E 3886 Ig-27 67 rs1300492136 0.6896 0.622 0.027 D 0.611 0.527 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
D/A 4005 Ig-28 68 None 0.707 None 1.0 D 0.852 0.802 None gnomAD-4.0.0 1.59219E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85793E-06 0 0
D/G 4005 Ig-28 68 rs1432768583 0.6969 0.257 1.0 D 0.773 0.787 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
D/G 4005 Ig-28 68 rs1432768583 0.6969 0.257 1.0 D 0.773 0.787 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/G 4005 Ig-28 68 rs1432768583 0.6969 0.257 1.0 D 0.773 0.787 None gnomAD-4.0.0 6.57125E-06 None None None None N None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
D/G 4766 Ig-30 67 rs878898536 0.9895 -0.984 0.998 D 0.761 0.912 None gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/G 4766 Ig-30 67 rs878898536 0.9895 -0.984 0.998 D 0.761 0.912 None gnomAD-4.0.0 1.36846E-05 None None None None N None 0 0 None 0 0 None 0 0 1.79896E-05 0 0
D/N 4766 Ig-30 67 rs981499527 0.9429 -0.947 0.999 D 0.78 0.745 0.613049571989 gnomAD-2.1.1 1.61E-05 None None None None N None 0 1.15989E-04 None 0 0 None 0 None 0 0 0
D/N 4766 Ig-30 67 rs981499527 0.9429 -0.947 0.999 D 0.78 0.745 0.613049571989 gnomAD-4.0.0 3.42114E-06 None None None None N None 0 8.94494E-05 None 0 0 None 0 0 8.99476E-07 0 0
D/G 4861 Ig-31 67 rs566100734 0.5349 None 0.805 D 0.701 0.815 0.0954503805726 gnomAD-4.0.0 1.59119E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
D/V 4861 Ig-31 67 rs566100734 0.8056 2.747 0.983 D 0.854 0.852 0.195762928549 gnomAD-2.1.1 4.64E-05 None None None None N None 0 0 None 0 0 None 3.92157E-04 None 0 7.8E-06 0
D/V 4861 Ig-31 67 rs566100734 0.8056 2.747 0.983 D 0.854 0.852 0.195762928549 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 4861 Ig-31 67 rs566100734 0.8056 2.747 0.983 D 0.854 0.852 0.195762928549 gnomAD-4.0.0 3.45855E-05 None None None None N None 0 0 None 0 0 None 0 0 2.39269E-06 3.48413E-04 0
D/H 4954 Ig-32 67 rs1443901302 0.838 None 1.0 D 0.823 0.75 0.7124574672 gnomAD-4.0.0 1.59309E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85972E-06 0 0
D/Y 4954 Ig-32 67 rs1443901302 0.7243 0.91 1.0 D 0.859 0.772 0.895316208075 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/Y 4954 Ig-32 67 rs1443901302 0.7243 0.91 1.0 D 0.859 0.772 0.895316208075 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85972E-06 0 0
D/A 5048 Ig-33 68 None 0.8595 None 0.999 D 0.868 0.913 0.771059023595 gnomAD-4.0.0 3.18261E-06 None None None None N None 0 0 None 0 5.54662E-05 None 0 0 0 0 0
D/E 5048 Ig-33 68 rs371699709 0.7207 -0.178 0.996 D 0.654 0.75 0.778112613574 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/E 5048 Ig-33 68 rs371699709 0.7207 -0.178 0.996 D 0.654 0.75 0.778112613574 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 5048 Ig-33 68 rs371699709 0.7207 -0.178 0.996 D 0.654 0.75 0.778112613574 gnomAD-4.0.0 9.29558E-06 None None None None N None 0 0 None 0 0 None 0 0 1.27145E-05 0 0
F/L 5234 Ig-35 67 None 0.2261 None None N 0.236 0.1 0.0762999501168 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 5327 Ig-36 67 rs1278975928 0.884 -0.492 1.0 D 0.585 0.484 0.315314060047 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/E 5327 Ig-36 67 rs1278975928 0.884 -0.492 1.0 D 0.585 0.484 0.315314060047 gnomAD-4.0.0 4.10546E-06 None None None None N None 2.98811E-05 0 None 0 0 None 0 0 3.59798E-06 0 1.65667E-05
D/H 5327 Ig-36 67 None 0.888 None 1.0 D 0.833 0.669 0.700541569318 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 0 None 0 0 1.799E-06 0 0
D/N 5327 Ig-36 67 rs868056944 0.7225 -0.669 1.0 D 0.769 0.617 0.724787515888 gnomAD-2.1.1 7.15E-06 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 7.83E-06 0
D/N 5327 Ig-36 67 rs868056944 0.7225 -0.669 1.0 D 0.769 0.617 0.724787515888 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 2.07039E-04 0
D/N 5327 Ig-36 67 rs868056944 0.7225 -0.669 1.0 D 0.769 0.617 0.724787515888 gnomAD-4.0.0 1.05352E-05 None None None None N None 1.33472E-05 1.667E-05 None 0 2.22856E-05 None 0 0 9.32398E-06 2.19626E-05 1.60123E-05
D/N 5423 Ig-37 67 rs915060068 0.4921 None 0.733 D 0.349 0.461 0.482792760554 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/N 5423 Ig-37 67 rs915060068 0.4921 None 0.733 D 0.349 0.461 0.482792760554 gnomAD-4.0.0 3.42177E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.79777E-05 0
D/Y 5423 Ig-37 67 rs915060068 0.6743 None 1.0 D 0.863 0.537 0.85727982643 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 5423 Ig-37 67 rs915060068 0.6743 None 1.0 D 0.863 0.537 0.85727982643 gnomAD-4.0.0 1.23961E-06 None None None None N None 1.33494E-05 0 None 0 0 None 0 0 8.47662E-07 0 0
D/G 5516 Ig-38 67 None 0.6186 None 0.989 D 0.729 0.742 0.648095352874 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/Y 5516 Ig-38 67 rs72648940 0.4655 0.576 0.994 D 0.845 0.491 None gnomAD-2.1.1 5.21779E-04 None None None None N None 4.13E-05 6.79656E-04 None 0 0 None 3.27E-05 None 4E-05 9.07583E-04 4.22297E-04
D/Y 5516 Ig-38 67 rs72648940 0.4655 0.576 0.994 D 0.845 0.491 None gnomAD-3.1.2 3.81123E-04 None None None None N None 2.41E-05 3.27397E-04 0 0 0 None 0 0 7.35013E-04 0 9.56938E-04
D/Y 5516 Ig-38 67 rs72648940 0.4655 0.576 0.994 D 0.845 0.491 None 1000 genomes 3.99361E-04 None None None None N None 0 1.4E-03 None None 0 1E-03 None None None 0 None
D/Y 5516 Ig-38 67 rs72648940 0.4655 0.576 0.994 D 0.845 0.491 None gnomAD-4.0.0 5.34162E-04 None None None None N None 2.66517E-05 6.0006E-04 None 0 0 None 1.87459E-04 3.3036E-04 6.65392E-04 2.19597E-05 3.682E-04
D/N 5610 Ig-39 68 None 0.2447 None 0.999 D 0.789 0.586 0.718595846919 gnomAD-4.0.0 1.59136E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85855E-06 0 0
D/V 5703 Ig-40 67 None 0.9375 None 1.0 D 0.887 0.863 0.918775219941 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/D 5796 Ig-41 67 rs397517485 0.1611 -2.267 0.995 N 0.805 0.439 0.21737058555 gnomAD-2.1.1 3.62E-05 None None None None N None 0 0 None 0 0 None 2.94118E-04 None 0 0 0
H/D 5796 Ig-41 67 rs397517485 0.1611 -2.267 0.995 N 0.805 0.439 0.21737058555 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07814E-04 0
H/D 5796 Ig-41 67 rs397517485 0.1611 -2.267 0.995 N 0.805 0.439 0.21737058555 gnomAD-4.0.0 1.17749E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.0864E-04 0
H/Y 5796 Ig-41 67 None 0.2177 None 0.982 N 0.701 0.43 0.423597194605 gnomAD-4.0.0 6.84206E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
D/G 5985 Ig-43 67 rs1452556096 0.9736 -0.407 0.996 D 0.716 0.771 0.699529956698 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/G 5985 Ig-43 67 rs1452556096 0.9736 -0.407 0.996 D 0.716 0.771 0.699529956698 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 2.23664E-05 None 0 0 None 0 0 8.99559E-07 0 0
D/N 5985 Ig-43 67 rs746248401 0.7925 -0.25 1.0 D 0.811 0.646 0.698733648705 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/V 5985 Ig-43 67 rs1452556096 0.9774 1.338 0.999 D 0.875 0.772 0.918250576733 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/V 5985 Ig-43 67 rs1452556096 0.9774 1.338 0.999 D 0.875 0.772 0.918250576733 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79912E-06 0 0
D/N 6078 Ig-44 67 rs748917636 0.602 -0.305 0.837 D 0.714 0.546 0.457741393631 gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 1.0304E-04 None 0 None 8.01E-05 2.35E-05 0
D/N 6078 Ig-44 67 rs748917636 0.602 -0.305 0.837 D 0.714 0.546 0.457741393631 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.56E-05 0 0 0 None 9.44E-05 0 2.94E-05 0 0
D/N 6078 Ig-44 67 rs748917636 0.602 -0.305 0.837 D 0.714 0.546 0.457741393631 gnomAD-4.0.0 1.42571E-05 None None None None N None 1.33558E-05 1.66889E-05 None 0 1.3397E-04 None 3.12607E-05 0 1.10203E-05 0 0
D/G 6265 Ig-46 67 rs1403981596 0.926 -1.004 0.928 D 0.771 0.849 0.718210980111 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
D/G 6265 Ig-46 67 rs1403981596 0.926 -1.004 0.928 D 0.771 0.849 0.718210980111 gnomAD-4.0.0 1.59169E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85915E-06 0 0
D/H 6265 Ig-46 67 rs764050491 0.9081 -0.48 0.997 D 0.819 0.732 0.711559257315 gnomAD-4.0.0 1.5917E-06 None None None None N None 0 0 None 0 0 None 1.88288E-05 0 0 0 0
D/G 6451 Ig-48 67 None 0.9525 None 1.0 D 0.787 0.888 0.660471063726 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 6451 Ig-48 67 rs763946767 0.5911 0.695 1.0 D 0.789 0.725 0.642796012904 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/N 6451 Ig-48 67 rs763946767 0.5911 0.695 1.0 D 0.789 0.725 0.642796012904 gnomAD-4.0.0 2.73801E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59877E-06 0 0
K/E 6640 Ig-50 67 None 0.1375 None 0.27 N 0.545 0.192 0.303123707472 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 6734 Ig-51 68 rs2079483133 0.5861 None 0.079 D 0.318 0.612 0.415313616471 gnomAD-4.0.0 1.3701E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80057E-06 0 0
D/E 6827 Ig-52 67 rs368033114 0.8733 -0.173 1.0 D 0.581 0.712 0.667860626873 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/E 6827 Ig-52 67 rs368033114 0.8733 -0.173 1.0 D 0.581 0.712 0.667860626873 gnomAD-4.0.0 6.84449E-06 None None None None N None 2.99115E-05 0 None 0 0 None 0 1.73732E-04 5.39815E-06 0 3.31488E-05
D/G 6827 Ig-52 67 rs911478772 0.9586 None 1.0 D 0.819 0.903 0.701507519776 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 6827 Ig-52 67 rs911478772 0.9586 None 1.0 D 0.819 0.903 0.701507519776 gnomAD-4.0.0 1.42092E-05 None None None None N None 1.74685E-05 0 None 0 0 None 0 0 1.44592E-05 0 3.40252E-05
N/S 6921 Ig-53 68 None 0.0702 None None N 0.245 0.144 0.252681307341 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 7014 Ig-54 67 rs1256056605 0.6969 None 0.993 D 0.789 0.639 0.664611728801 gnomAD-4.0.0 1.36862E-06 None None None None N None 0 0 None 0 0 None 0 1.73611E-04 8.99564E-07 0 0
D/V 7014 Ig-54 67 rs1484212258 0.9118 None 0.997 D 0.874 0.839 0.922917791787 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 7014 Ig-54 67 rs1484212258 0.9118 None 0.997 D 0.874 0.839 0.922917791787 gnomAD-4.0.0 6.57125E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47029E-05 0 0
Q/H 7203 Ig-56 67 rs1374160884 0.1796 None 0.002 N 0.371 0.158 0.128392430309 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/H 7203 Ig-56 67 rs1374160884 0.1796 None 0.002 N 0.371 0.158 0.128392430309 gnomAD-4.0.0 2.47953E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39098E-06 0 0
Q/P 7203 Ig-56 67 None 0.3114 None 0.523 D 0.648 0.38 0.386721274199 gnomAD-4.0.0 2.46701E-05 None None None None N None 2.99258E-05 0 None 0 0 None 0 0 3.06336E-05 1.16044E-05 0
Q/R 7203 Ig-56 67 None 0.1441 None 0.351 N 0.519 0.298 0.28492961333 gnomAD-4.0.0 6.8526E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00953E-07 0 0
D/E 7296 Ig-57 67 rs767681708 0.7111 -0.444 0.989 D 0.635 0.641 0.535294132878 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/E 7296 Ig-57 67 rs767681708 0.7111 -0.444 0.989 D 0.635 0.641 0.535294132878 gnomAD-4.0.0 8.89577E-06 None None None None N None 0 0 None 0 0 None 0 0 1.07945E-05 0 1.65706E-05
D/H 7296 Ig-57 67 rs1391650834 0.8272 -0.585 1.0 D 0.767 0.653 0.692857881624 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
D/H 7296 Ig-57 67 rs1391650834 0.8272 -0.585 1.0 D 0.767 0.653 0.692857881624 gnomAD-4.0.0 1.59174E-06 None None None None N None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
D/E 7389 Ig-58 67 None 0.6398 None 0.433 D 0.347 0.53 0.508815697893 gnomAD-4.0.0 1.59282E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86053E-06 0 0
H/N 7485 Ig-59 67 rs1372592118 0.1415 None 0.352 D 0.305 0.234 0.236278675362 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
H/N 7485 Ig-59 67 rs1372592118 0.1415 None 0.352 D 0.305 0.234 0.236278675362 gnomAD-4.0.0 2.47982E-06 None None None None N None 0 0 None 0 2.23015E-05 None 0 0 0 2.19746E-05 1.60236E-05
D/E 7581 Ig-60 67 rs540314973 0.9292 -0.551 0.302 D 0.372 0.535 0.426670027402 gnomAD-2.1.1 1.21E-05 None None None None N None 1.29299E-04 2.9E-05 None 0 0 None 0 None 0 0 0
D/E 7581 Ig-60 67 rs540314973 0.9292 -0.551 0.302 D 0.372 0.535 0.426670027402 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 0 0 0
D/E 7581 Ig-60 67 rs540314973 0.9292 -0.551 0.302 D 0.372 0.535 0.426670027402 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
D/E 7581 Ig-60 67 rs540314973 0.9292 -0.551 0.302 D 0.372 0.535 0.426670027402 gnomAD-4.0.0 5.12558E-06 None None None None N None 3.37621E-05 3.38903E-05 None 0 0 None 0 0 0 0 0
D/N 7581 Ig-60 67 rs1433348204 0.8498 -0.264 1.0 D 0.768 0.549 0.67901058461 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 7581 Ig-60 67 rs1433348204 0.8498 -0.264 1.0 D 0.768 0.549 0.67901058461 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 7581 Ig-60 67 rs1433348204 0.8498 -0.264 1.0 D 0.768 0.549 0.67901058461 gnomAD-4.0.0 1.23963E-06 None None None None N None 0 1.66739E-05 None 0 0 None 0 0 8.47764E-07 0 0
D/V 7581 Ig-60 67 None 0.9837 None 1.0 D 0.897 0.823 0.921184757123 gnomAD-4.0.0 1.59201E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
D/Y 7581 Ig-60 67 rs1433348204 0.9596 1.065 1.0 D 0.903 0.543 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 7581 Ig-60 67 rs1433348204 0.9596 1.065 1.0 D 0.903 0.543 None gnomAD-4.0.0 6.81795E-06 None None None None N None 1.33518E-05 0 None 0 0 None 0 0 8.47764E-06 0 0
D/A 7675 Ig-61 68 None 0.9448 None 1.0 D 0.873 0.79 0.862342405572 gnomAD-4.0.0 3.18931E-06 None None None None N None 0 0 None 0 0 None 0 0 5.73444E-06 0 0
D/N 7675 Ig-61 68 rs552951988 0.7386 -0.735 1.0 D 0.805 0.567 0.651334235377 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
D/N 7675 Ig-61 68 rs552951988 0.7386 -0.735 1.0 D 0.805 0.567 0.651334235377 gnomAD-4.0.0 5.47706E-06 None None None None N None 0 0 None 0 0 None 0 0 0 9.28117E-05 0
D/Y 7675 Ig-61 68 rs552951988 0.8923 0.339 1.0 D 0.899 0.567 0.895285619443 gnomAD-2.1.1 1.23319E-03 None None None None N None 0 0 None 0 0 None 1.1114E-02 None 0 0 7.02839E-04
D/Y 7675 Ig-61 68 rs552951988 0.8923 0.339 1.0 D 0.899 0.567 0.895285619443 gnomAD-3.1.2 3.61476E-04 None None None None N None 0 0 0 0 0 None 0 0 0 1.13777E-02 0
D/Y 7675 Ig-61 68 rs552951988 0.8923 0.339 1.0 D 0.899 0.567 0.895285619443 1000 genomes 2.19649E-03 None None None None N None 0 0 None None 0 0 None None None 1.12E-02 None
D/Y 7675 Ig-61 68 rs552951988 0.8923 0.339 1.0 D 0.899 0.567 0.895285619443 gnomAD-4.0.0 7.17337E-04 None None None None N None 0 0 None 0 2.22955E-05 None 0 4.95213E-04 5.08883E-06 1.21284E-02 6.88727E-04
D/N 7768 Ig-62 67 rs72648973 0.8051 -0.104 1.0 D 0.783 0.593 None gnomAD-2.1.1 7.71252E-04 None None None None N None 3.30688E-04 4.24352E-04 None 9.67492E-04 0 None 0 None 7.99E-05 1.38342E-03 5.62114E-04
D/N 7768 Ig-62 67 rs72648973 0.8051 -0.104 1.0 D 0.783 0.593 None gnomAD-3.1.2 8.08604E-04 None None None None N None 3.13737E-04 5.2404E-04 0 1.1534E-03 0 None 2.82539E-04 0 1.36753E-03 2.07555E-04 4.78011E-04
D/N 7768 Ig-62 67 rs72648973 0.8051 -0.104 1.0 D 0.783 0.593 None gnomAD-4.0.0 1.27476E-03 None None None None N None 2.53293E-04 4.83317E-04 None 8.4488E-04 0 None 1.24973E-04 0 1.62927E-03 3.29468E-05 8.16366E-04
D/Y 7768 Ig-62 67 None 0.9653 None 1.0 D 0.857 0.746 0.884366441292 gnomAD-4.0.0 6.84272E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99549E-07 0 0
N/T 7862 Ig-63 68 rs794729629 0.1383 -0.543 0.006 N 0.458 0.203 0.344945010812 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/T 7862 Ig-63 68 rs794729629 0.1383 -0.543 0.006 N 0.458 0.203 0.344945010812 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43308E-05 0
D/A 7955 Ig-64 67 rs767163830 0.7804 0.105 0.978 D 0.799 0.737 0.818275426986 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/A 7955 Ig-64 67 rs767163830 0.7804 0.105 0.978 D 0.799 0.737 0.818275426986 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
D/E 7955 Ig-64 67 rs759495262 0.6856 -0.539 0.989 D 0.623 0.709 0.618151229915 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/E 7955 Ig-64 67 rs759495262 0.6856 -0.539 0.989 D 0.623 0.709 0.618151229915 gnomAD-4.0.0 2.73696E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 1.15942E-05 3.31334E-05
D/E 8051 Ig-65 67 rs368438797 0.4573 -0.349 0.928 D 0.643 0.687 0.562131562789 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/E 8051 Ig-65 67 rs368438797 0.4573 -0.349 0.928 D 0.643 0.687 0.562131562789 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/E 8051 Ig-65 67 rs368438797 0.4573 -0.349 0.928 D 0.643 0.687 0.562131562789 gnomAD-4.0.0 4.95772E-06 None None None None N None 0 0 None 0 0 None 0 0 6.78106E-06 0 0
D/N 8051 Ig-65 67 rs368226720 0.1775 -0.541 0.343 D 0.405 0.561 0.467416895013 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.35E-05 0
D/N 8051 Ig-65 67 rs368226720 0.1775 -0.541 0.343 D 0.405 0.561 0.467416895013 gnomAD-3.1.2 3.29E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 4.41E-05 2.07297E-04 0
D/N 8051 Ig-65 67 rs368226720 0.1775 -0.541 0.343 D 0.405 0.561 0.467416895013 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
D/N 8051 Ig-65 67 rs368226720 0.1775 -0.541 0.343 D 0.405 0.561 0.467416895013 gnomAD-4.0.0 9.2954E-06 None None None None N None 1.33348E-05 0 None 0 0 None 0 0 1.01717E-05 2.19606E-05 0
E/A 8144 Ig-66 67 rs16866465 0.1376 1.123 0.003 N 0.449 0.227 None gnomAD-2.1.1 1.75062E-01 None None None None N None 1.52217E-01 1.7377E-01 None 1.22413E-01 4.30462E-01 None 2.22538E-01 None 9.45222E-02 1.50195E-01 1.61608E-01
E/A 8144 Ig-66 67 rs16866465 0.1376 1.123 0.003 N 0.449 0.227 None gnomAD-3.1.2 1.64715E-01 None None None None N None 1.5358E-01 1.70055E-01 4.71491E-01 1.25864E-01 4.33191E-01 None 9.86805E-02 1.20253E-01 1.54076E-01 2.23766E-01 1.65392E-01
E/A 8144 Ig-66 67 rs16866465 0.1376 1.123 0.003 N 0.449 0.227 None 1000 genomes 2.38818E-01 None None None None N None 1.732E-01 1.83E-01 None None 4.375E-01 1.571E-01 None None None 2.464E-01 None
E/A 8144 Ig-66 67 rs16866465 0.1376 1.123 0.003 N 0.449 0.227 None gnomAD-4.0.0 1.63466E-01 None None None None N None 1.53334E-01 1.73385E-01 None 1.23767E-01 4.42663E-01 None 9.43438E-02 1.92079E-01 1.52621E-01 2.20242E-01 1.70103E-01
E/D 8144 Ig-66 67 rs756559627 0.1379 -1.13 0.003 N 0.431 0.034 0.0297737177859 gnomAD-2.1.1 1.17847E-04 None None None None N None 0 0 None 0 0 None 0 None 4.39754E-04 1.56365E-04 2.80662E-04
E/D 8144 Ig-66 67 rs756559627 0.1379 -1.13 0.003 N 0.431 0.034 0.0297737177859 gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 1.88395E-04 0 5.88E-05 0 0
E/D 8144 Ig-66 67 rs756559627 0.1379 -1.13 0.003 N 0.431 0.034 0.0297737177859 gnomAD-4.0.0 1.14028E-04 None None None None N None 0 0 None 0 0 None 5.4679E-04 0 1.16127E-04 0 1.92111E-04
E/G 8144 Ig-66 67 rs16866465 0.1502 0.345 0.007 N 0.539 0.234 0.388812400583 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11408E-04 None 0 None 0 0 0
E/G 8144 Ig-66 67 rs16866465 0.1502 0.345 0.007 N 0.539 0.234 0.388812400583 gnomAD-4.0.0 2.73688E-06 None None None None N None 0 0 None 0 7.55896E-05 None 0 0 0 0 1.65667E-05
E/K 8144 Ig-66 67 rs761751961 0.1233 1.065 0.003 N 0.449 0.16 0.204665344411 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 8144 Ig-66 67 rs761751961 0.1233 1.065 0.003 N 0.449 0.16 0.204665344411 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
E/K 8144 Ig-66 67 rs761751961 0.1233 1.065 0.003 N 0.449 0.16 0.204665344411 gnomAD-4.0.0 5.12449E-06 None None None None N None 0 0 None 0 2.42483E-05 None 0 0 0 4.02026E-05 0
D/H 8330 Ig-68 67 None 0.8203 None 1.0 D 0.845 0.644 0.661693444866 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Q 8426 Ig-69 67 rs1409245989 0.5085 -1.514 0.954 N 0.606 0.255 0.154104182512 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
H/Q 8426 Ig-69 67 rs1409245989 0.5085 -1.514 0.954 N 0.606 0.255 0.154104182512 gnomAD-4.0.0 1.59252E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43414E-05 0
D/N 8522 Ig-70 67 rs199619070 0.8731 -0.12 0.999 D 0.735 0.596 None gnomAD-2.1.1 9.64E-05 None None None None N None 0 5.66E-05 None 0 0 None 0 None 8E-05 1.6406E-04 2.81452E-04
D/N 8522 Ig-70 67 rs199619070 0.8731 -0.12 0.999 D 0.735 0.596 None gnomAD-3.1.2 1.31423E-04 None None None None N None 4.82E-05 0 0 0 0 None 9.41E-05 0 2.49919E-04 0 0
D/N 8522 Ig-70 67 rs199619070 0.8731 -0.12 0.999 D 0.735 0.596 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
D/N 8522 Ig-70 67 rs199619070 0.8731 -0.12 0.999 D 0.735 0.596 None gnomAD-4.0.0 1.61129E-04 None None None None N None 2.66567E-05 0 None 0 0 None 4.68735E-05 0 2.08535E-04 1.09808E-05 1.28098E-04
D/V 8709 Ig-72 67 rs1444153454 0.9211 1.683 1.0 D 0.849 0.856 0.807306291417 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/V 8709 Ig-72 67 rs1444153454 0.9211 1.683 1.0 D 0.849 0.856 0.807306291417 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 8709 Ig-72 67 rs1444153454 0.9211 1.683 1.0 D 0.849 0.856 0.807306291417 gnomAD-4.0.0 6.5741E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47046E-05 0 0
N/S 8803 Ig-73 68 rs12693164 0.0575 -0.869 0.018 N 0.345 0.186 None gnomAD-2.1.1 1.77519E-01 None None None None N None 1.62461E-01 1.76252E-01 None 1.26429E-01 4.30533E-01 None 2.31679E-01 None 9.44995E-02 1.50207E-01 1.63854E-01
N/S 8803 Ig-73 68 rs12693164 0.0575 -0.869 0.018 N 0.345 0.186 None gnomAD-3.1.2 1.68341E-01 None None None None N None 1.63632E-01 1.73939E-01 4.71429E-01 1.3076E-01 4.34414E-01 None 9.80965E-02 1.23418E-01 1.5406E-01 2.33637E-01 1.68582E-01
N/S 8803 Ig-73 68 rs12693164 0.0575 -0.869 0.018 N 0.345 0.186 None 1000 genomes 2.47005E-01 None None None None N None 1.936E-01 1.859E-01 None None 4.365E-01 1.561E-01 None None None 2.607E-01 None
N/S 8803 Ig-73 68 rs12693164 0.0575 -0.869 0.018 N 0.345 0.186 None gnomAD-4.0.0 1.64667E-01 None None None None N None 1.64431E-01 1.76194E-01 None 1.28514E-01 4.42963E-01 None 9.425E-02 2.04193E-01 1.52411E-01 2.29363E-01 1.72119E-01
D/E 8896 Ig-74 67 rs1198151007 0.7067 -0.193 1.0 D 0.58 0.732 0.733745208057 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65618E-04
D/E 8896 Ig-74 67 rs1198151007 0.7067 -0.193 1.0 D 0.58 0.732 0.733745208057 gnomAD-4.0.0 1.59171E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02554E-05
D/G 8896 Ig-74 67 None 0.8066 None 1.0 D 0.776 0.88 0.685509544888 gnomAD-4.0.0 1.59162E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85881E-06 0 0
D/H 8992 Ig-75 67 None 0.8101 None 1.0 D 0.861 0.589 0.626919690049 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 9178 Ig-77 67 rs747327863 0.9158 -0.475 0.826 D 0.677 0.772 0.596650592983 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
D/G 9178 Ig-77 67 rs747327863 0.9158 -0.475 0.826 D 0.677 0.772 0.596650592983 gnomAD-4.0.0 6.36472E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14318E-05 0 0
D/V 9178 Ig-77 67 None 0.9139 None 0.92 D 0.766 0.782 0.782820974753 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
D/N 9271 Ig-78 67 None 0.4416 None 1.0 D 0.775 0.742 0.711529652176 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 9367 Ig-79 67 rs748483786 0.0875 -1.428 None None 0.418 0.078 0.352693368174 gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.12E-05 0
L/F 9367 Ig-79 67 rs748483786 0.0875 -1.428 None None 0.418 0.078 0.352693368174 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
L/F 9367 Ig-79 67 rs748483786 0.0875 -1.428 None None 0.418 0.078 0.352693368174 gnomAD-4.0.0 2.23083E-05 None None None None N None 0 1.66689E-05 None 0 0 None 0 1.64474E-04 2.79708E-05 0 1.60092E-05
D/N 9463 Ig-80 67 rs769166539 0.6497 -0.204 0.884 None 0.37 0.516 0.650465148921 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/N 9463 Ig-80 67 rs769166539 0.6497 -0.204 0.884 None 0.37 0.516 0.650465148921 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 9463 Ig-80 67 rs769166539 0.6497 -0.204 0.884 None 0.37 0.516 0.650465148921 gnomAD-4.0.0 6.56996E-06 None None None None N None 2.41231E-05 0 None 0 0 None 0 0 0 0 0
D/Y 9463 Ig-80 67 rs769166539 0.88 1.511 1.0 None 0.906 0.518 0.795741560664 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
D/Y 9463 Ig-80 67 rs769166539 0.88 1.511 1.0 None 0.906 0.518 0.795741560664 gnomAD-4.0.0 1.59157E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85798E-06 0 0
D/E 9560 Ig-81 68 rs377713076 0.6628 -0.585 1.0 None 0.589 0.482 0.185906805712 gnomAD-2.1.1 4.01E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/E 9560 Ig-81 68 rs377713076 0.6628 -0.585 1.0 None 0.589 0.482 0.185906805712 gnomAD-4.0.0 6.84179E-07 None None None None N None 2.98739E-05 0 None 0 0 None 0 0 0 0 0
D/H 9560 Ig-81 68 rs771843862 0.7855 -0.165 1.0 None 0.824 0.64 0.540606920606 gnomAD-2.1.1 6.37E-05 None None None None N None 2.29568E-04 0 None 0 0 None 0 None 0 0 0
D/H 9560 Ig-81 68 rs771843862 0.7855 -0.165 1.0 None 0.824 0.64 0.540606920606 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/H 9560 Ig-81 68 rs771843862 0.7855 -0.165 1.0 None 0.824 0.64 0.540606920606 gnomAD-4.0.0 1.85897E-06 None None None None N None 4.0047E-05 0 None 0 0 None 0 0 0 0 0
D/N 9560 Ig-81 68 rs771843862 0.5052 -0.652 1.0 None 0.777 0.588 0.523546030903 gnomAD-2.1.1 1.3648E-04 None None None None N None 0 0 None 0 0 None 1.07843E-03 None 0 8.86E-06 0
D/N 9560 Ig-81 68 rs771843862 0.5052 -0.652 1.0 None 0.777 0.588 0.523546030903 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 2.06782E-04 0
D/N 9560 Ig-81 68 rs771843862 0.5052 -0.652 1.0 None 0.777 0.588 0.523546030903 gnomAD-4.0.0 7.62176E-05 None None None None N None 1.3349E-05 0 None 0 0 None 0 0 1.6104E-05 9.88034E-04 2.08127E-04
D/N 9656 Ig-82 67 rs1064797277 0.4743 None 0.946 None 0.804 0.589 0.606648057779 gnomAD-4.0.0 1.36839E-06 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 0 0 1.65662E-05
D/G 9765 Ig-83 68 None 0.9968 None 1.0 None 0.797 0.796 0.590730187373 gnomAD-4.0.0 1.591E-06 None None None None N None 5.65291E-05 0 None 0 0 None 0 0 0 0 0
D/N 9967 Ig-84 68 rs777682199 0.9169 -0.953 1.0 None 0.801 0.779 0.804573646758 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
D/N 9967 Ig-84 68 rs777682199 0.9169 -0.953 1.0 None 0.801 0.779 0.804573646758 gnomAD-4.0.0 1.59193E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43476E-05 0
D/A 10143 Ig-86 66 rs766264907 0.9965 None 1.0 None 0.864 0.645 0.751722793294 gnomAD-4.0.0 1.11375E-05 None None None None N None 0 0 None 0 1.94078E-04 None 0 0 0 0 0
D/G 10143 Ig-86 66 rs766264907 0.9969 -0.243 1.0 None 0.796 0.655 0.703670902771 gnomAD-2.1.1 4.01E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/G 10143 Ig-86 66 rs766264907 0.9969 -0.243 1.0 None 0.796 0.655 0.703670902771 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
D/G 10143 Ig-86 66 rs766264907 0.9969 -0.243 1.0 None 0.796 0.655 0.703670902771 gnomAD-4.0.0 6.57531E-06 None None None None N None 2.41511E-05 0 None 0 0 None 0 0 0 0 0
D/N 10143 Ig-86 66 rs1553875406 0.983 None 1.0 None 0.797 0.53 0.669929112853 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 0 0 0
D/N 13752 Ig-87 69 rs1349773180 0.9287 -0.582 1.0 D 0.767 0.774 0.691037376318 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/N 13752 Ig-87 69 rs1349773180 0.9287 -0.582 1.0 D 0.767 0.774 0.691037376318 gnomAD-4.0.0 1.57411E-05 None None None None N None 2.98954E-05 0 None 0 0 None 0 0 1.79925E-05 0 3.31444E-05
D/V 13752 Ig-87 69 None 0.9922 None 1.0 D 0.867 0.895 0.870765017468 gnomAD-4.0.0 1.59228E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85986E-06 0 0
D/E 14118 Ig-91 65 None 0.9026 None 1.0 D 0.546 0.613 0.530852358449 gnomAD-4.0.0 1.36899E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79938E-06 0 0
D/V 14118 Ig-91 65 None 0.9753 None 1.0 D 0.836 0.819 0.838979274215 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
D/G 14295 Ig-93 65 None 0.9195 None 1.0 D 0.772 0.831 0.794774646785 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 0 None 1.88445E-05 0 0 0 0
D/H 14295 Ig-93 65 rs1162989897 0.9324 0.077 1.0 D 0.837 0.575 0.769386222844 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/H 14295 Ig-93 65 rs1162989897 0.9324 0.077 1.0 D 0.837 0.575 0.769386222844 gnomAD-4.0.0 1.59232E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85954E-06 0 0
M/I 14384 Ig-94 66 rs1454108479 0.6709 -0.634 0.936 N 0.399 0.236 0.331619326243 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
M/I 14384 Ig-94 66 rs1454108479 0.6709 -0.634 0.936 N 0.399 0.236 0.331619326243 gnomAD-4.0.0 1.59252E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02663E-05
M/V 14384 Ig-94 66 rs1450926397 0.2947 None 0.665 N 0.362 0.203 0.315903272564 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 14384 Ig-94 66 rs1450926397 0.2947 None 0.665 N 0.362 0.203 0.315903272564 gnomAD-4.0.0 2.03004E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40996E-06 0 0
D/G 14473 Ig-95 66 None 0.9294 None 1.0 D 0.789 0.863 0.704013138179 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
D/H 14473 Ig-95 66 rs397517573 0.9304 0.276 1.0 D 0.834 0.649 0.700962985929 gnomAD-2.1.1 2.39722E-04 None None None None N None 0 0 None 4.7453E-03 0 None 0 None 0 1.09799E-04 5.6243E-04
D/H 14473 Ig-95 66 rs397517573 0.9304 0.276 1.0 D 0.834 0.649 0.700962985929 gnomAD-3.1.2 1.1839E-04 None None None None N None 0 0 0 4.03691E-03 0 None 0 0 4.41E-05 0 4.79386E-04
D/H 14473 Ig-95 66 rs397517573 0.9304 0.276 1.0 D 0.834 0.649 0.700962985929 gnomAD-4.0.0 1.16535E-04 None None None None N None 0 0 None 4.32637E-03 0 None 0 0 3.05201E-05 1.09808E-05 3.68436E-04
D/V 14562 Ig-96 66 None 0.7639 None 1.0 D 0.828 0.862 0.72858195137 gnomAD-4.0.0 1.60496E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45412E-05 0
Q/H 14740 Ig-98 66 None 0.5468 None 0.996 N 0.547 0.239 0.272639205421 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
D/E 14829 Ig-99 65 rs1559907952 0.4379 -0.132 0.198 D 0.307 0.541 0.634385825132 gnomAD-2.1.1 4.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.1E-06 0
D/E 14829 Ig-99 65 rs1559907952 0.4379 -0.132 0.198 D 0.307 0.541 0.634385825132 gnomAD-4.0.0 6.88732E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02778E-07 0 0
D/V 14918 Ig-100 66 None 0.9752 None 1.0 D 0.812 0.896 0.711987036522 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
D/H 15007 Ig-101 66 rs1356461359 0.9787 0.038 1.0 D 0.787 0.834 0.691146523942 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.65E-05 None 0 None 0 0 0
D/H 15007 Ig-101 66 rs1356461359 0.9787 0.038 1.0 D 0.787 0.834 0.691146523942 gnomAD-4.0.0 3.42441E-06 None None None None N None 0 0 None 0 5.06817E-05 None 0 0 1.80006E-06 1.16031E-05 0
D/Y 15007 Ig-101 66 rs1356461359 0.9781 0.614 1.0 D 0.801 0.821 0.895427483255 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.65E-05 None 0 None 0 0 0
D/Y 15007 Ig-101 66 rs1356461359 0.9781 0.614 1.0 D 0.801 0.821 0.895427483255 gnomAD-4.0.0 6.84882E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16031E-05 0
D/N 15456 Ig-106 66 None 0.9306 None 1.0 D 0.771 0.757 0.773741610481 gnomAD-4.0.0 1.59515E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86517E-06 0 0
D/E 15545 Ig-107 66 None 0.8991 None 1.0 D 0.573 0.668 0.790128647075 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/E 15631 Ig-108 64 rs372868510 0.4674 -0.216 0.058 D 0.393 0.473 0.539792608675 gnomAD-2.1.1 1.79E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 3.13E-05 0
D/E 15631 Ig-108 64 rs372868510 0.4674 -0.216 0.058 D 0.393 0.473 0.539792608675 gnomAD-3.1.2 3.95E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 4.42E-05 0 0
D/E 15631 Ig-108 64 rs372868510 0.4674 -0.216 0.058 D 0.393 0.473 0.539792608675 gnomAD-4.0.0 4.90029E-05 None None None None N None 4.01316E-05 0 None 0 0 None 0 0 6.36122E-05 0 1.60339E-05
D/Y 16029 Ig-109 62 None 0.9667 None 1.0 D 0.841 0.75 0.90494787378 gnomAD-4.0.0 1.5933E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86225E-06 0 0
D/E 17021 Ig-111 67 rs760244297 0.9435 -0.447 1.0 D 0.583 0.751 0.451023696535 gnomAD-2.1.1 3.22E-05 None None None None N None 0 1.45079E-04 None 0 0 None 0 None 0 2.67E-05 0
D/E 17021 Ig-111 67 rs760244297 0.9435 -0.447 1.0 D 0.583 0.751 0.451023696535 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 1.96773E-04 0 0 0 None 0 0 0 0 0
D/E 17021 Ig-111 67 rs760244297 0.9435 -0.447 1.0 D 0.583 0.751 0.451023696535 gnomAD-4.0.0 1.67418E-05 None None None None N None 1.33633E-05 1.33462E-04 None 0 0 None 0 0 1.35684E-05 0 3.20472E-05
D/G 17021 Ig-111 67 rs1353851775 0.9842 -1.223 1.0 D 0.781 0.834 0.609343871639 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/G 17021 Ig-111 67 rs1353851775 0.9842 -1.223 1.0 D 0.781 0.834 0.609343871639 gnomAD-4.0.0 6.84576E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15985E-05 0
D/V 17021 Ig-111 67 None 0.9837 None 1.0 D 0.857 0.834 0.895635020298 gnomAD-4.0.0 1.36915E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99878E-07 0 1.65788E-05
D/V 17343 Ig-112 93 rs201796622 0.9935 0.703 0.973 D 0.917 0.857 0.887541276338 gnomAD-2.1.1 4.44E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.68E-06 0
D/V 17343 Ig-112 93 rs201796622 0.9935 0.703 0.973 D 0.917 0.857 0.887541276338 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 17343 Ig-112 93 rs201796622 0.9935 0.703 0.973 D 0.917 0.857 0.887541276338 gnomAD-4.0.0 2.52137E-06 None None None None N None 0 0 None 0 0 None 0 0 3.42683E-06 0 0
D/Y 17343 Ig-112 93 rs2055729807 0.9882 None 0.998 D 0.938 0.804 0.85440441475 gnomAD-4.0.0 1.662E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.56216E-05 0
D/G 17738 Ig-113 62 rs773447539 0.9932 -0.518 1.0 D 0.773 0.889 0.675418728564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/G 17738 Ig-113 62 rs773447539 0.9932 -0.518 1.0 D 0.773 0.889 0.675418728564 gnomAD-4.0.0 6.84395E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99692E-07 0 0
D/V 17738 Ig-113 62 rs773447539 0.9939 1.226 1.0 D 0.834 0.889 0.923914431233 gnomAD-2.1.1 4.83E-05 None None None None N None 0 2.89805E-04 None 0 0 None 0 None 0 1.78E-05 0
D/V 17738 Ig-113 62 rs773447539 0.9939 1.226 1.0 D 0.834 0.889 0.923914431233 gnomAD-3.1.2 3.29E-05 None None None None N None 0 2.62123E-04 0 0 0 None 0 0 0 0 4.78469E-04
D/V 17738 Ig-113 62 rs773447539 0.9939 1.226 1.0 D 0.834 0.889 0.923914431233 gnomAD-4.0.0 2.23165E-05 None None None None N None 0 2.83466E-04 None 0 0 None 0 0 1.35659E-05 0 4.80615E-05
D/N 18039 Ig-114 72 rs765148928 0.3084 -0.209 1.0 D 0.735 0.662 0.582828786496 gnomAD-2.1.1 4.44E-05 None None None None N None 0 0 None 0 0 None 0 None 0 9.84E-05 0
D/N 18039 Ig-114 72 rs765148928 0.3084 -0.209 1.0 D 0.735 0.662 0.582828786496 gnomAD-3.1.2 3.95E-05 None None None None N None 0 6.57E-05 0 0 0 None 0 0 7.36E-05 0 0
D/N 18039 Ig-114 72 rs765148928 0.3084 -0.209 1.0 D 0.735 0.662 0.582828786496 gnomAD-4.0.0 7.19509E-05 None None None None N None 0 1.66917E-05 None 0 0 None 0 0 9.07587E-05 0 1.28209E-04
H/D 18453 Ig-115 72 None 0.4511 None 1.0 N 0.703 0.469 0.220303561663 gnomAD-4.0.0 3.20112E-06 None None None None N None 0 0 None 0 0 None 0 0 5.73421E-06 0 0
H/R 18453 Ig-115 72 None 0.9551 None 1.0 N 0.733 0.554 0.407357902709 gnomAD-4.0.0 6.85901E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.17437E-05 0
D/G 18758 Ig-116 71 None 0.9622 None 1.0 D 0.779 0.872 0.647406887873 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 18758 Ig-116 71 rs748163322 0.6468 None 1.0 D 0.78 0.744 0.584367751947 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/N 19157 Ig-117 63 None 0.291 None 0.999 N 0.683 0.393 0.345405024496 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/P 19157 Ig-117 63 None 0.9255 None 1.0 N 0.861 0.615 0.651368938621 gnomAD-4.0.0 1.59263E-06 None None None None N None 0 0 None 0 2.7852E-05 None 0 0 0 0 0
H/Q 19157 Ig-117 63 None 0.534 None 1.0 N 0.808 0.34 0.252162846088 gnomAD-4.0.0 6.84461E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99656E-07 0 0
D/N 20543 Ig-121 65 None 0.9289 None 1.0 D 0.773 0.683 0.603979500719 gnomAD-4.0.0 1.36888E-06 None None None None N None 0 0 None 0 0 None 1.87301E-05 0 8.99682E-07 0 0
D/N 20838 Ig-122 70 None 0.9003 None 1.0 D 0.783 0.689 0.762446115887 gnomAD-4.0.0 1.36862E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79911E-06 0 0
D/N 21240 Ig-123 64 rs1031557327 0.8479 None 1.0 D 0.774 0.707 0.686399706189 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 21240 Ig-123 64 rs1031557327 0.8479 None 1.0 D 0.774 0.707 0.686399706189 gnomAD-4.0.0 2.56637E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79136E-06 0 0
D/Y 21533 Ig-124 65 rs1484580543 0.7375 0.733 1.0 D 0.841 0.573 0.854310461085 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
D/Y 21533 Ig-124 65 rs1484580543 0.7375 0.733 1.0 D 0.841 0.573 0.854310461085 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86064E-06 0 0
D/E 21930 Ig-125 65 rs794727432 0.3732 -0.313 0.001 D 0.303 0.313 0.331365685468 gnomAD-2.1.1 1.22E-05 None None None None N None 0 2.95E-05 None 0 0 None 0 None 0 1.8E-05 0
D/E 21930 Ig-125 65 rs794727432 0.3732 -0.313 0.001 D 0.303 0.313 0.331365685468 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/E 21930 Ig-125 65 rs794727432 0.3732 -0.313 0.001 D 0.303 0.313 0.331365685468 gnomAD-4.0.0 1.80611E-05 None None None None N None 0 3.36134E-05 None 0 0 None 0 0 2.29762E-05 0 0
D/N 21930 Ig-125 65 None 0.2139 None 0.549 D 0.645 0.528 0.476205827853 gnomAD-4.0.0 1.37605E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80656E-06 0 0
D/N 22328 Ig-126 64 None 0.9719 None 1.0 D 0.787 0.793 0.680912940599 gnomAD-4.0.0 1.59242E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
D/V 22328 Ig-126 64 rs749871897 0.9946 0.762 1.0 D 0.848 0.911 0.852438954655 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/V 22328 Ig-126 64 rs749871897 0.9946 0.762 1.0 D 0.848 0.911 0.852438954655 gnomAD-4.0.0 1.59243E-06 None None None None N None 5.66572E-05 0 None 0 0 None 0 0 0 0 0
D/H 22617 Ig-127 58 None 0.9091 None 1.0 D 0.858 0.685 0.729913700919 gnomAD-4.0.0 1.59181E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85945E-06 0 0
D/G 23014 Ig-128 65 rs1394733017 0.801 -0.895 0.978 D 0.691 0.885 0.679795130832 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/G 23014 Ig-128 65 rs1394733017 0.801 -0.895 0.978 D 0.691 0.885 0.679795130832 gnomAD-4.0.0 1.59224E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85982E-06 0 0
D/G 23409 Ig-129 65 rs1709909119 0.9905 None 0.958 D 0.759 0.865 0.628213846089 gnomAD-4.0.0 1.7107E-05 None None None None N None 0 0 None 0 0 None 0 0 2.24894E-05 0 0
D/H 23700 Ig-130 64 rs1559444507 0.9736 None 1.0 D 0.827 0.725 0.621202144873 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/H 23700 Ig-130 64 rs1559444507 0.9736 None 1.0 D 0.827 0.725 0.621202144873 gnomAD-4.0.0 2.05308E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69874E-06 0 0
D/N 24096 Ig-131 68 None 0.58 None 1.0 D 0.775 0.576 0.593030115291 gnomAD-4.0.0 1.59655E-06 None None None None N None 0 0 None 0 2.78272E-05 None 0 0 0 0 0
D/E 24782 Ig-133 67 rs1463579400 0.977 None 1.0 D 0.574 0.702 0.556695477184 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31079E-04 0 0 0 None 0 0 0 0 0
D/E 24782 Ig-133 67 rs1463579400 0.977 None 1.0 D 0.574 0.702 0.556695477184 gnomAD-4.0.0 5.1274E-06 None None None None N None 0 6.78127E-05 None 0 0 None 0 0 0 0 0
D/G 24782 Ig-133 67 rs1708279198 0.9888 None 1.0 D 0.769 0.876 0.665323958199 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
D/G 24782 Ig-133 67 rs1708279198 0.9888 None 1.0 D 0.769 0.876 0.665323958199 gnomAD-4.0.0 6.57583E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07211E-04 0
D/H 25178 Ig-134 68 rs878863074 0.8756 None 1.0 D 0.838 0.696 0.596874347621 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/H 25178 Ig-134 68 rs878863074 0.8756 None 1.0 D 0.838 0.696 0.596874347621 gnomAD-4.0.0 6.57678E-06 None None None None N None 2.41394E-05 0 None 0 0 None 0 0 0 0 0
D/N 25178 Ig-134 68 rs878863074 0.7541 -0.4 1.0 D 0.811 0.66 None gnomAD-2.1.1 1.43E-05 None None None None N None 4.13E-05 5.67E-05 None 0 0 None 0 None 0 0 1.40766E-04
D/N 25178 Ig-134 68 rs878863074 0.7541 -0.4 1.0 D 0.811 0.66 None gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 6.56E-05 0 0 1.93349E-04 None 0 0 0 0 0
D/N 25178 Ig-134 68 rs878863074 0.7541 -0.4 1.0 D 0.811 0.66 None gnomAD-4.0.0 1.36367E-05 None None None None N None 5.34202E-05 5.00417E-05 None 0 6.70151E-05 None 0 0 8.47725E-06 0 3.20307E-05
D/N 25575 Ig-135 62 rs749711979 0.8812 -0.576 1.0 D 0.791 0.775 0.725831142202 gnomAD-2.1.1 1.07E-05 None None None None N None 8.27E-05 2.84E-05 None 0 0 None 0 None 0 0 0
D/N 25575 Ig-135 62 rs749711979 0.8812 -0.576 1.0 D 0.791 0.775 0.725831142202 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
D/N 25575 Ig-135 62 rs749711979 0.8812 -0.576 1.0 D 0.791 0.775 0.725831142202 gnomAD-4.0.0 4.33919E-06 None None None None N None 8.01218E-05 1.66839E-05 None 0 0 None 0 0 0 0 0
D/E 25864 Ig-136 67 None 0.914 None 0.958 D 0.607 0.644 0.645225581225 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
D/G 25864 Ig-136 67 rs780362373 0.9639 -1.139 0.919 D 0.717 0.797 None gnomAD-2.1.1 8.07E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.94E-06 0
D/G 25864 Ig-136 67 rs780362373 0.9639 -1.139 0.919 D 0.717 0.797 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/G 25864 Ig-136 67 rs780362373 0.9639 -1.139 0.919 D 0.717 0.797 None gnomAD-4.0.0 3.84479E-06 None None None None N None 3.38329E-05 0 None 0 0 None 0 0 2.39418E-06 0 0
D/N 25864 Ig-136 67 None 0.8391 None 0.142 D 0.368 0.698 0.485991781493 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
D/N 26260 Ig-137 68 None 0.8739 None 1.0 D 0.813 0.821 0.657207152337 gnomAD-4.0.0 1.63483E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.5152E-05 0
D/V 26260 Ig-137 68 rs1221038194 0.992 None 1.0 D 0.874 0.92 0.916336800185 gnomAD-4.0.0 1.38395E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80816E-06 0 0
D/G 26657 Ig-138 64 rs1397158186 0.9347 -1.043 1.0 D 0.775 0.893 0.716290961394 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/G 26657 Ig-138 64 rs1397158186 0.9347 -1.043 1.0 D 0.775 0.893 0.716290961394 gnomAD-4.0.0 1.36852E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79907E-06 0 0
D/Y 26657 Ig-138 64 rs781076407 0.8622 -0.113 1.0 D 0.851 0.87 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/Y 26657 Ig-138 64 rs781076407 0.8622 -0.113 1.0 D 0.851 0.87 None gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 5.88E-05 0 0
D/Y 26657 Ig-138 64 rs781076407 0.8622 -0.113 1.0 D 0.851 0.87 None gnomAD-4.0.0 1.54938E-05 None None None None N None 1.33522E-05 0 None 0 0 None 0 0 1.94967E-05 1.09789E-05 0
D/V 26946 Ig-139 67 rs1705319606 0.9644 None 1.0 D 0.811 0.89 0.924449110081 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
D/V 26946 Ig-139 67 rs1705319606 0.9644 None 1.0 D 0.811 0.89 0.924449110081 gnomAD-4.0.0 6.57419E-06 None None None None N None 0 6.56082E-05 None 0 0 None 0 0 0 0 0
D/Y 26946 Ig-139 67 rs571011004 0.9614 0.464 1.0 D 0.83 0.88 0.903031728821 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67112E-04 None 0 None 0 0 0
D/Y 26946 Ig-139 67 rs571011004 0.9614 0.464 1.0 D 0.83 0.88 0.903031728821 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.87147E-04 None 0 0 0 0 0
D/Y 26946 Ig-139 67 rs571011004 0.9614 0.464 1.0 D 0.83 0.88 0.903031728821 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
D/Y 26946 Ig-139 67 rs571011004 0.9614 0.464 1.0 D 0.83 0.88 0.903031728821 gnomAD-4.0.0 2.4789E-06 None None None None N None 0 0 None 0 8.92021E-05 None 0 0 0 0 0
D/G 27343 Ig-140 66 None 0.9507 None 1.0 D 0.817 0.838 0.712127334774 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
D/E 27740 Ig-141 65 rs1364251085 0.9267 None 1.0 D 0.615 0.777 0.569844293628 gnomAD-4.0.0 1.59192E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85886E-06 0 0
D/N 27740 Ig-141 65 rs776130801 0.8656 -0.755 1.0 D 0.789 0.616 0.657750020267 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/N 27740 Ig-141 65 rs776130801 0.8656 -0.755 1.0 D 0.789 0.616 0.657750020267 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 27740 Ig-141 65 rs776130801 0.8656 -0.755 1.0 D 0.789 0.616 0.657750020267 gnomAD-4.0.0 6.57471E-06 None None None None N None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
D/E 28029 Ig-142 67 rs750468978 0.9457 -0.316 0.958 D 0.586 0.727 0.467161347466 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
D/E 28029 Ig-142 67 rs750468978 0.9457 -0.316 0.958 D 0.586 0.727 0.467161347466 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 28029 Ig-142 67 rs750468978 0.9457 -0.316 0.958 D 0.586 0.727 0.467161347466 gnomAD-4.0.0 3.84511E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18071E-06 0 0
D/G 28029 Ig-142 67 rs758569836 0.9711 -0.827 0.919 D 0.679 0.854 0.6184965563 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
D/G 28029 Ig-142 67 rs758569836 0.9711 -0.827 0.919 D 0.679 0.854 0.6184965563 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85907E-06 0 0
D/G 28424 Ig-143 67 rs879049486 0.9711 None 1.0 D 0.777 0.887 None gnomAD-4.0.0 4.78984E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29616E-06 0 0
D/Y 28819 Ig-144 65 None 0.9729 None 1.0 D 0.855 0.784 0.920955482883 gnomAD-4.0.0 3.19552E-06 None None None None N None 0 0 None 0 0 None 0 0 5.73658E-06 0 0
D/A 29111 Ig-145 67 None 0.9555 None 1.0 D 0.831 0.877 0.816108210376 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/N 29906 Ig-147 65 rs770892973 0.8441 -0.808 1.0 D 0.78 0.793 0.687474101776 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/N 29906 Ig-147 65 rs770892973 0.8441 -0.808 1.0 D 0.78 0.793 0.687474101776 gnomAD-4.0.0 4.78952E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29621E-06 0 0
H/D 30198 Ig-148 67 rs750619537 0.1602 -0.789 None N 0.399 0.124 0.0666544352282 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
H/D 30198 Ig-148 67 rs750619537 0.1602 -0.789 None N 0.399 0.124 0.0666544352282 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/D 30198 Ig-148 67 rs750619537 0.1602 -0.789 None N 0.399 0.124 0.0666544352282 gnomAD-4.0.0 2.4814E-06 None None None None N None 0 0 None 0 0 None 0 0 3.3922E-06 0 0
H/Q 30198 Ig-148 67 rs765307374 0.3861 -0.568 0.001 N 0.354 0.111 0.242825505644 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
H/Q 30198 Ig-148 67 rs765307374 0.3861 -0.568 0.001 N 0.354 0.111 0.242825505644 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
H/Q 30198 Ig-148 67 rs765307374 0.3861 -0.568 0.001 N 0.354 0.111 0.242825505644 gnomAD-4.0.0 1.24051E-05 None None None None N None 0 0 None 0 0 None 0 0 1.69597E-05 0 0
H/R 30198 Ig-148 67 rs1479999162 0.6953 -0.885 0.029 D 0.481 0.267 0.331619326243 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
H/R 30198 Ig-148 67 rs1479999162 0.6953 -0.885 0.029 D 0.481 0.267 0.331619326243 gnomAD-4.0.0 4.10941E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39956E-06 0 0
H/Y 30593 Ig-149 62 None 0.2076 None 0.999 N 0.669 0.423 0.451504584351 gnomAD-4.0.0 1.59135E-06 None None None None N None 0 0 None 0 2.77316E-05 None 0 0 0 0 0
D/E 30990 Ig-150 64 rs781038013 0.9382 -0.298 0.767 D 0.363 0.505 0.394384168047 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
D/E 30990 Ig-150 64 rs781038013 0.9382 -0.298 0.767 D 0.363 0.505 0.394384168047 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
D/H 30990 Ig-150 64 rs747622770 0.958 None 1.0 D 0.831 0.825 0.647156358147 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 30990 Ig-150 64 rs747622770 0.958 None 1.0 D 0.831 0.825 0.647156358147 gnomAD-4.0.0 9.29525E-06 None None None None N None 0 0 None 0 0 None 0 0 1.27139E-05 0 0
D/N 30990 Ig-150 64 rs747622770 0.9235 -0.321 0.999 D 0.804 0.782 0.677940303636 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
D/N 30990 Ig-150 64 rs747622770 0.9235 -0.321 0.999 D 0.804 0.782 0.677940303636 gnomAD-4.0.0 6.84191E-07 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 0 0
D/V 30990 Ig-150 64 rs1206561468 0.9852 0.28 0.999 D 0.863 0.886 0.906290120609 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/V 30990 Ig-150 64 rs1206561468 0.9852 0.28 0.999 D 0.863 0.886 0.906290120609 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
D/Y 30990 Ig-150 64 None 0.9701 None 1.0 D 0.862 0.865 0.894255340531 gnomAD-4.0.0 1.36838E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31906E-05 0
D/E 31282 Ig-151 65 rs1697827813 0.9496 None 1.0 D 0.577 0.803 0.478527412683 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/E 31282 Ig-151 65 rs1697827813 0.9496 None 1.0 D 0.577 0.803 0.478527412683 gnomAD-4.0.0 6.57324E-06 None None None None N None 0 6.54965E-05 None 0 0 None 0 0 0 0 0
D/E 31682 Ig-152 62 rs1447931152 0.9146 -0.206 1.0 D 0.603 0.685 0.67028951277 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/E 31682 Ig-152 62 rs1447931152 0.9146 -0.206 1.0 D 0.603 0.685 0.67028951277 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/E 31682 Ig-152 62 rs1447931152 0.9146 -0.206 1.0 D 0.603 0.685 0.67028951277 gnomAD-4.0.0 1.23938E-06 None None None None N None 1.33483E-05 0 None 0 0 None 0 0 8.47621E-07 0 0
D/G 31682 Ig-152 62 None 0.9722 None 1.0 D 0.785 0.885 0.73442195143 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85847E-06 0 0
D/G 32079 Ig-153 63 rs1559127150 0.9918 None 1.0 D 0.78 0.833 0.718191611325 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/G 32079 Ig-153 63 rs1559127150 0.9918 None 1.0 D 0.78 0.833 0.718191611325 gnomAD-4.0.0 3.18298E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71768E-06 0 0
D/H 32079 Ig-153 63 rs200540781 0.9783 0.5 1.0 D 0.819 0.633 None gnomAD-2.1.1 8.21E-05 None None None None N None 0 2.83E-05 None 0 5.13E-05 None 3.26819E-04 None 1.19923E-04 6.25E-05 0
D/H 32079 Ig-153 63 rs200540781 0.9783 0.5 1.0 D 0.819 0.633 None gnomAD-3.1.2 7.23E-05 None None None None N None 0 0 0 0 3.861E-04 None 1.88466E-04 0 8.82E-05 2.07039E-04 0
D/H 32079 Ig-153 63 rs200540781 0.9783 0.5 1.0 D 0.819 0.633 None gnomAD-4.0.0 5.88735E-05 None None None None N None 0 1.66661E-05 None 0 2.00624E-04 None 1.56235E-04 1.65125E-04 3.64504E-05 3.4039E-04 0
D/N 32079 Ig-153 63 None 0.9553 -0.581 1.0 D 0.775 0.631 None gnomAD-2.1.1 1.82021E-04 None None None None N None 8.27E-05 4.24208E-04 None 0 0 None 0 None 0 2.49891E-04 2.80662E-04
D/N 32079 Ig-153 63 None 0.9553 -0.581 1.0 D 0.775 0.631 None gnomAD-3.1.2 2.03853E-04 None None None None N None 4.83E-05 4.58595E-04 0 0 0 None 0 0 2.94109E-04 0 9.56023E-04
D/N 32079 Ig-153 63 None 0.9553 -0.581 1.0 D 0.775 0.631 None gnomAD-4.0.0 3.08644E-04 None None None None N None 8.0156E-05 4.50135E-04 None 0 0 None 0 1.64528E-04 3.69587E-04 5.48992E-05 3.6833E-04
D/Y 32079 Ig-153 63 rs200540781 0.9845 0.975 1.0 D 0.834 0.684 0.931670636465 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/N 32373 Ig-154 67 None 0.9454 None 1.0 D 0.783 0.768 0.605542551707 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85834E-06 0 0
D/Y 32769 Ig-155 62 rs564151542 0.9469 -0.124 1.0 D 0.823 0.526 0.855879272531 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/Y 32769 Ig-155 62 rs564151542 0.9469 -0.124 1.0 D 0.823 0.526 0.855879272531 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/Y 32769 Ig-155 62 rs564151542 0.9469 -0.124 1.0 D 0.823 0.526 0.855879272531 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
D/Y 32769 Ig-155 62 rs564151542 0.9469 -0.124 1.0 D 0.823 0.526 0.855879272531 gnomAD-4.0.0 6.56711E-06 None None None None N None 0 6.54022E-05 None 0 0 None 0 0 0 0 0
H/Q 33264 Ig-157 62 None 0.628 None 0.997 N 0.685 0.288 0.229924730088 gnomAD-4.0.0 1.59875E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43926E-05 0
D/G 34203 Ig-160 67 None 0.9631 None 1.0 D 0.793 0.866 0.63676537582 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 34203 Ig-160 67 rs1189437049 0.8831 0.069 1.0 D 0.799 0.757 0.736534092445 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
D/N 34203 Ig-160 67 rs1189437049 0.8831 0.069 1.0 D 0.799 0.757 0.736534092445 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/N 34203 Ig-160 67 rs1189437049 0.8831 0.069 1.0 D 0.799 0.757 0.736534092445 gnomAD-4.0.0 3.09822E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23773E-06 0 0
D/N 34327 Ig-161 70 None 0.8096 None 0.235 N 0.353 0.563 0.372087925617 gnomAD-4.0.0 1.59099E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
D/Y 34430 Ig-162 68 rs751794473 0.948 0.732 1.0 D 0.843 0.894 0.682335091196 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
D/Y 34430 Ig-162 68 rs751794473 0.948 0.732 1.0 D 0.843 0.894 0.682335091196 gnomAD-4.0.0 7.95646E-06 None None None None N None 0 0 None 0 0 None 0 0 1.42883E-05 0 0
D/N 35008 Ig-163 67 rs1238039888 0.8203 -1.013 1.0 D 0.771 0.755 0.715963578734 gnomAD-2.1.1 2.54712E-04 None None None None N None 0 0 None 0 0 None 0 None 2.87853E-04 3.88752E-04 9.19118E-04
D/N 35008 Ig-163 67 rs1238039888 0.8203 -1.013 1.0 D 0.771 0.755 0.715963578734 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 9.41E-05 0 5.88E-05 0 0
D/N 35008 Ig-163 67 rs1238039888 0.8203 -1.013 1.0 D 0.771 0.755 0.715963578734 gnomAD-4.0.0 8.0553E-06 None None None None N None 1.33508E-05 0 None 0 0 None 4.68574E-05 0 5.93278E-06 0 3.20215E-05
D/N 35195 Ig-164 67 rs752458663 0.4786 -0.179 1.0 D 0.803 0.705 0.661029647469 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.86E-06 3.30579E-04
D/N 35195 Ig-164 67 rs752458663 0.4786 -0.179 1.0 D 0.803 0.705 0.661029647469 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
D/N 35195 Ig-164 67 rs752458663 0.4786 -0.179 1.0 D 0.803 0.705 0.661029647469 gnomAD-4.0.0 1.30129E-05 None None None None N None 0 1.66656E-05 None 0 0 None 1.56304E-05 3.28731E-04 1.35606E-05 0 1.60097E-05
D/V 35195 Ig-164 67 None 0.8867 None 1.0 D 0.879 0.86 0.850925399445 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
D/G 35353 Ig-165 68 None 0.9262 None 1.0 D 0.776 0.81 0.59553206065 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 35353 Ig-165 68 rs780037060 0.8861 0.968 1.0 D 0.831 0.749 0.575311710502 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/H 35353 Ig-165 68 rs780037060 0.8861 0.968 1.0 D 0.831 0.749 0.575311710502 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
D/N 35353 Ig-165 68 rs780037060 0.6811 None 1.0 D 0.784 0.668 0.543428762037 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85753E-06 0 0
D/E 35486 Ig-166 67 None 0.6011 None 0.992 D 0.636 0.652 0.585473498874 gnomAD-4.0.0 6.85896E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00161E-07 0 0
D/N 35671 Ig-167 65 rs1397922467 0.4375 -0.512 0.117 N 0.629 0.409 0.37953744168 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/N 35671 Ig-167 65 rs1397922467 0.4375 -0.512 0.117 N 0.629 0.409 0.37953744168 gnomAD-4.0.0 2.05345E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69938E-06 0 0
D/N 35768 Ig-168 67 rs794729571 0.3836 -0.408 0.977 D 0.391 0.641 0.617340952311 gnomAD-2.1.1 6.37E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 6.48E-05 0
D/N 35768 Ig-168 67 rs794729571 0.3836 -0.408 0.977 D 0.391 0.641 0.617340952311 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 35768 Ig-168 67 rs794729571 0.3836 -0.408 0.977 D 0.391 0.641 0.617340952311 gnomAD-4.0.0 6.81569E-06 None None None None N None 7.99723E-05 1.66583E-05 None 0 0 None 0 0 2.54271E-06 1.09801E-05 0
D/V 35768 Ig-168 67 None 0.8815 None 1.0 D 0.863 0.904 0.828757793854 gnomAD-4.0.0 1.59101E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85778E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.