Structural position:

  • Domain Type: Ig
  • Aligned Position: 16
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A'

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
V/A 17 Ig-1 12 None 0.2775 None None D 0.101 0.248 0.569949186141 gnomAD-4.0.0 1.20032E-06 None None None -0.448(TCAP) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 17 Ig-1 12 None 0.1235 None 0.042 D 0.42 0.408 0.639750416835 gnomAD-4.0.0 1.20032E-06 None None None -0.787(TCAP) N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
V/M 115 Ig-2 12 rs564777385 0.7976 -1.502 1.0 D 0.702 0.531 0.694597339098 gnomAD-2.1.1 3.57E-05 None None None -0.556(TCAP) N None 4.01E-05 1.41957E-04 None 0 0 None 6.63E-05 None 0 1.56E-05 0
V/M 115 Ig-2 12 rs564777385 0.7976 -1.502 1.0 D 0.702 0.531 0.694597339098 gnomAD-3.1.2 3.29E-05 None None None -0.556(TCAP) N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 4.13907E-04 0
V/M 115 Ig-2 12 rs564777385 0.7976 -1.502 1.0 D 0.702 0.531 0.694597339098 1000 genomes 3.99361E-04 None None None -0.556(TCAP) N None 0 0 None None 0 0 None None None 2E-03 None
V/M 115 Ig-2 12 rs564777385 0.7976 -1.502 1.0 D 0.702 0.531 0.694597339098 gnomAD-4.0.0 1.36526E-05 None None None -0.556(TCAP) N None 1.33412E-05 8.34975E-05 None 0 0 None 0 0 8.48585E-06 4.40907E-05 3.20441E-05
V/G 954 Ig-3 12 None 0.9141 None 1.0 D 0.677 0.767 0.9214070867 gnomAD-4.0.0 1.5906E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85667E-06 0 0
C/S 1468 Ig-6 12 None 0.7468 None 0.99 N 0.579 0.629 0.72213654127 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 7.32654E-05
I/K 1567 Ig-7 12 None 0.6347 None 0.773 N 0.583 0.494 0.794301526555 gnomAD-4.0.0 1.59077E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85678E-06 0 0
I/R 1567 Ig-7 12 None 0.5319 None 0.773 N 0.585 0.506 0.797486517669 gnomAD-4.0.0 1.59077E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85678E-06 0 0
I/T 1567 Ig-7 12 rs145957227 0.2562 -1.779 0.324 N 0.413 0.267 None gnomAD-2.1.1 7.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
I/T 1567 Ig-7 12 rs145957227 0.2562 -1.779 0.324 N 0.413 0.267 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 1567 Ig-7 12 rs145957227 0.2562 -1.779 0.324 N 0.413 0.267 None gnomAD-4.0.0 7.68423E-06 None None None None N None 0 0 None 0 0 None 0 0 1.43521E-05 0 0
L/F 1714 Ig-8 12 rs2092264988 0.4131 None 0.994 D 0.617 0.353 0.628758500363 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/F 1714 Ig-8 12 rs2092264988 0.4131 None 0.994 D 0.617 0.353 0.628758500363 gnomAD-4.0.0 2.56119E-06 None None None None I None 1.69096E-05 0 None 0 0 None 0 0 2.39167E-06 0 0
L/H 1714 Ig-8 12 rs750997358 0.6905 -1.699 1.0 D 0.634 0.604 0.900287583318 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.84E-06 0
L/H 1714 Ig-8 12 rs750997358 0.6905 -1.699 1.0 D 0.634 0.604 0.900287583318 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/H 1714 Ig-8 12 rs750997358 0.6905 -1.699 1.0 D 0.634 0.604 0.900287583318 gnomAD-4.0.0 6.57039E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46977E-05 0 0
V/I 1852 Ig-9 12 None 0.1323 None 0.997 D 0.466 0.417 0.774770343904 gnomAD-4.0.0 6.84119E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99306E-07 0 0
V/A 2089 Ig-10 12 rs1436344691 0.4463 -1.699 0.999 D 0.453 0.653 0.729153541304 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/A 2089 Ig-10 12 rs1436344691 0.4463 -1.699 0.999 D 0.453 0.653 0.729153541304 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 2089 Ig-10 12 rs1436344691 0.4463 -1.699 0.999 D 0.453 0.653 0.729153541304 gnomAD-4.0.0 1.85873E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54235E-06 0 0
V/E 2089 Ig-10 12 None 0.907 None 1.0 D 0.688 0.819 0.891950675791 gnomAD-4.0.0 3.42044E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49648E-06 0 0
A/P 2185 Ig-11 12 rs367653049 0.975 -1.049 1.0 D 0.745 0.772 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/P 2185 Ig-11 12 rs367653049 0.975 -1.049 1.0 D 0.745 0.772 None gnomAD-4.0.0 6.57462E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
V/F 2278 Ig-12 12 rs779274451 0.8031 -1.141 1.0 D 0.693 0.688 0.885741665235 gnomAD-2.1.1 7.99E-06 None None None None N None 6.16E-05 0 None 0 0 None 0 None 0 8.83E-06 0
V/F 2278 Ig-12 12 rs779274451 0.8031 -1.141 1.0 D 0.693 0.688 0.885741665235 gnomAD-4.0.0 5.47484E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19511E-06 0 0
V/I 2278 Ig-12 12 rs779274451 0.1339 -0.233 0.997 D 0.469 0.409 0.643537847441 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 2278 Ig-12 12 rs779274451 0.1339 -0.233 0.997 D 0.469 0.409 0.643537847441 gnomAD-4.0.0 6.84355E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15939E-05 0
V/D 2367 Ig-13 12 rs1234347852 0.9474 -0.96 0.999 D 0.625 0.863 0.889776735302 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 6.53E-05 None 0 0 0
V/D 2367 Ig-13 12 rs1234347852 0.9474 -0.96 0.999 D 0.625 0.863 0.889776735302 gnomAD-4.0.0 1.3682E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0
C/Y 2544 Ig-15 12 rs1271799350 0.6772 None 1.0 D 0.727 0.624 0.808542943238 gnomAD-4.0.0 1.59084E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85672E-06 0 0
V/I 2631 Ig-16 11 rs766753906 0.1091 -0.749 0.999 N 0.481 0.397 None gnomAD-2.1.1 3.89E-05 None None None None N None 1.20135E-04 8.47E-05 None 0 0 None 0 None 0 3.88E-05 0
V/I 2631 Ig-16 11 rs766753906 0.1091 -0.749 0.999 N 0.481 0.397 None gnomAD-3.1.2 6.57E-05 None None None None N None 1.44837E-04 0 0 0 0 None 0 0 4.41E-05 2.07039E-04 0
V/I 2631 Ig-16 11 rs766753906 0.1091 -0.749 0.999 N 0.481 0.397 None gnomAD-4.0.0 3.03636E-05 None None None None N None 1.46866E-04 5.00183E-05 None 0 0 None 0 0 2.45794E-05 3.29366E-05 4.80215E-05
V/A 2718 Ig-17 12 rs2091324546 0.5541 None 0.999 D 0.481 0.667 0.746317035393 gnomAD-4.0.0 1.59126E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
A/V 2806 Ig-18 12 None 0.2738 None 0.92 N 0.459 0.323 0.446613173091 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/M 2893 Ig-19 12 None 0.2737 None 0.982 D 0.579 0.552 0.694889576946 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/T 2980 Ig-20 12 rs72647885 0.549 -1.659 1.0 N 0.712 0.461 None gnomAD-2.1.1 5.06553E-04 None None None None N None 4.12726E-03 3.67335E-04 None 1.93125E-04 0 None 6.53E-05 None 0 1.31957E-04 8.31716E-04
A/T 2980 Ig-20 12 rs72647885 0.549 -1.659 1.0 N 0.712 0.461 None gnomAD-3.1.2 1.25668E-03 None None None None N None 3.94196E-03 1.17986E-03 0 2.88351E-04 0 None 0 3.16456E-03 7.35E-05 0 1.43678E-03
A/T 2980 Ig-20 12 rs72647885 0.549 -1.659 1.0 N 0.712 0.461 None 1000 genomes 1.59744E-03 None None None None N None 4.5E-03 2.9E-03 None None 0 0 None None None 0 None
A/T 2980 Ig-20 12 rs72647885 0.549 -1.659 1.0 N 0.712 0.461 None gnomAD-4.0.0 2.78227E-04 None None None None N None 3.97588E-03 6.16811E-04 None 2.70289E-04 0 None 0 4.9505E-04 4.91536E-05 1.31758E-04 5.27983E-04
V/A 3069 Ig-21 12 None 0.7532 None 0.994 D 0.447 0.699 0.677981630403 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
V/I 3069 Ig-21 12 rs2090837308 0.1439 None 0.543 N 0.249 0.326 0.471778926243 gnomAD-4.0.0 1.3682E-06 None None None None I None 0 0 None 0 2.52309E-05 None 0 0 0 1.15931E-05 0
V/L 3069 Ig-21 12 None 0.751 None 0.948 D 0.395 0.464 0.538792235971 gnomAD-4.0.0 4.10461E-06 None None None None I None 0 2.23654E-05 None 0 0 None 0 0 4.49648E-06 0 0
V/F 3158 Ig-22 12 rs748114137 0.7319 -1.336 0.997 D 0.681 0.734 0.784949373506 gnomAD-2.1.1 1.2E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.66E-05 0
V/F 3158 Ig-22 12 rs748114137 0.7319 -1.336 0.997 D 0.681 0.734 0.784949373506 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 2.08943E-04 0
V/F 3158 Ig-22 12 rs748114137 0.7319 -1.336 0.997 D 0.681 0.734 0.784949373506 gnomAD-4.0.0 1.55181E-05 None None None None I None 0 0 None 0 0 None 0 0 2.03778E-05 1.09907E-05 0
V/L 3158 Ig-22 12 None 0.7433 None 0.863 D 0.483 0.537 0.669649519912 gnomAD-4.0.0 6.8535E-07 None None None None I None 0 0 None 0 0 None 0 0 9.01114E-07 0 0
V/G 3250 Ig-23 12 rs55634230 0.7487 -2.165 0.997 D 0.713 0.789 0.92261678279 gnomAD-2.1.1 7.18E-05 None None None None N None 0 2.89E-05 None 0 8.17082E-04 None 3.27E-05 None 0 0 1.63559E-04
V/G 3250 Ig-23 12 rs55634230 0.7487 -2.165 0.997 D 0.713 0.789 0.92261678279 gnomAD-3.1.2 5.26E-05 None None None None N None 0 0 0 0 1.53905E-03 None 0 0 0 0 0
V/G 3250 Ig-23 12 rs55634230 0.7487 -2.165 0.997 D 0.713 0.789 0.92261678279 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
V/G 3250 Ig-23 12 rs55634230 0.7487 -2.165 0.997 D 0.713 0.789 0.92261678279 gnomAD-4.0.0 2.16864E-05 None None None None N None 0 3.33244E-05 None 0 4.45692E-04 None 0 0 0 5.49028E-05 1.28025E-04
V/L 3250 Ig-23 12 None 0.5732 None 0.973 D 0.507 0.494 0.660534388617 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/I 3356 Ig-24 12 rs763323132 0.2871 -0.305 0.852 N 0.411 0.255 0.43126412278 gnomAD-2.1.1 1.19E-05 None None None None N None 1.23031E-04 0 None 0 0 None 0 None 0 8.8E-06 0
T/I 3356 Ig-24 12 rs763323132 0.2871 -0.305 0.852 N 0.411 0.255 0.43126412278 gnomAD-4.0.0 3.42046E-06 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 3.5973E-06 0 0
T/S 3356 Ig-24 12 None 0.2494 None 0.704 N 0.431 0.192 0.254761474806 gnomAD-4.0.0 6.84092E-07 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 0 0 0
V/G 3476 Ig-25 12 None 0.5445 None None None None 0.495 None gnomAD-4.0.0 1.59243E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86072E-06 0 0
V/M 3476 Ig-25 12 rs774551356 0.5095 -0.656 None None None 0.344 None gnomAD-2.1.1 7.15E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
V/M 3476 Ig-25 12 rs774551356 0.5095 -0.656 None None None 0.344 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
V/M 3476 Ig-25 12 rs774551356 0.5095 -0.656 None None None 0.344 None gnomAD-4.0.0 1.97011E-05 None None None None N None 7.22091E-05 0 None 0 0 None 0 0 0 0 0
V/I 3671 Ig-26 12 None 0.1085 None None None None 0.17 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
I/M 3831 Ig-27 12 rs1183777377 0.1119 -0.85 0.427 N 0.497 0.112 None gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/M 3831 Ig-27 12 rs1183777377 0.1119 -0.85 0.427 N 0.497 0.112 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
I/M 3831 Ig-27 12 rs1183777377 0.1119 -0.85 0.427 N 0.497 0.112 None gnomAD-4.0.0 6.40653E-06 None None None None N None 0 1.6956E-05 None 0 0 None 0 0 9.57304E-06 0 0
I/T 3831 Ig-27 12 None 0.0939 None None N 0.265 0.213 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/R 3949 Ig-28 12 None 0.6522 None 1.0 N 0.749 0.59 None gnomAD-4.0.0 1.59106E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85786E-06 0 0
C/Y 3949 Ig-28 12 None 0.534 None 1.0 N 0.725 0.402 None gnomAD-4.0.0 5.47339E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29602E-06 1.15934E-05 0
V/A 4711 Ig-30 12 rs1217292413 0.4141 -1.427 0.994 N 0.447 0.519 0.583333579207 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
V/A 4711 Ig-30 12 rs1217292413 0.4141 -1.427 0.994 N 0.447 0.519 0.583333579207 gnomAD-4.0.0 6.84448E-07 None None None None I None 0 2.23734E-05 None 0 0 None 0 0 0 0 0
V/E 4711 Ig-30 12 None 0.824 None 0.999 D 0.713 0.774 0.800342540491 gnomAD-4.0.0 1.3689E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79932E-06 0 0
T/A 4806 Ig-31 12 rs2081384233 0.0769 None 0.454 N 0.387 0.234 0.242244723065 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/A 4806 Ig-31 12 rs2081384233 0.0769 None 0.454 N 0.387 0.234 0.242244723065 gnomAD-4.0.0 6.57479E-06 None None None None N None 0 6.55222E-05 None 0 0 None 0 0 0 0 0
T/I 4806 Ig-31 12 None 0.2551 None 0.669 N 0.513 0.218 0.437100570223 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/I 4993 Ig-33 13 None 0.503 None 0.028 N 0.279 0.122 0.419713421852 gnomAD-4.0.0 1.60967E-06 None None None None I None 0 0 None 0 0 None 0 0 2.89059E-06 0 0
M/V 4993 Ig-33 13 None 0.155 None 0.001 N 0.117 0.151 0.298745278005 gnomAD-4.0.0 1.61024E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44923E-05 0
I/T 5086 Ig-34 12 rs938020572 0.19 None None N 0.225 0.302 0.58162856405 gnomAD-4.0.0 3.2832E-06 None None None None I None 0 0 None 0 0 None 0 0 5.8948E-06 0 0
I/V 5086 Ig-34 12 rs1560838962 0.0767 None None N 0.133 0.092 0.384086055536 gnomAD-2.1.1 4.27E-06 None None None None I None 0 0 None 0 0 None 3.78E-05 None 0 0 0
I/V 5086 Ig-34 12 rs1560838962 0.0767 None None N 0.133 0.092 0.384086055536 gnomAD-4.0.0 2.08059E-06 None None None None I None 0 0 None 0 0 None 0 0 9.08176E-07 2.42407E-05 0
A/T 5179 Ig-35 12 rs536853382 0.0902 None 0.034 N 0.369 0.25 0.285316908763 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/M 5272 Ig-36 12 rs746406893 0.5455 -0.216 0.999 D 0.495 0.658 0.830710548829 gnomAD-2.1.1 2.86E-05 None None None None I None 2.48077E-04 2.83E-05 None 0 0 None 0 None 0 7.84E-06 0
V/M 5272 Ig-36 12 rs746406893 0.5455 -0.216 0.999 D 0.495 0.658 0.830710548829 gnomAD-3.1.2 7.88E-05 None None None None I None 1.92985E-04 1.30907E-04 0 0 0 None 0 0 1.47E-05 0 4.78469E-04
V/M 5272 Ig-36 12 rs746406893 0.5455 -0.216 0.999 D 0.495 0.658 0.830710548829 gnomAD-4.0.0 1.92121E-05 None None None None I None 2.93662E-04 5.0005E-05 None 0 0 None 0 0 4.23834E-06 0 1.60128E-05
S/G 5368 Ig-37 12 None 0.0808 None None N 0.087 0.126 0.144782658237 gnomAD-4.0.0 3.20634E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.89143E-05 0
S/N 5368 Ig-37 12 None 0.169 None 0.055 D 0.383 0.183 0.186928172975 gnomAD-4.0.0 1.37251E-06 None None None None I None 2.99868E-05 0 None 0 0 None 0 0 9.0158E-07 0 0
S/R 5368 Ig-37 12 None 0.5172 None 0.171 N 0.473 0.265 0.306377322295 gnomAD-4.0.0 1.6018E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87877E-06 0 0
V/A 5461 Ig-38 12 None 0.129 None None D 0.135 0.28 0.475192790171 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 5461 Ig-38 12 rs749477796 0.0763 -0.439 None N 0.154 0.22 0.365892764245 gnomAD-2.1.1 4.18E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.15E-06 0
V/I 5461 Ig-38 12 rs749477796 0.0763 -0.439 None N 0.154 0.22 0.365892764245 gnomAD-4.0.0 3.44203E-06 None None None None N None 0 0 None 0 0 None 0 0 4.51481E-06 0 0
L/M 5554 Ig-39 12 rs2080687572 0.1116 None 1.0 N 0.605 0.228 0.352693368174 gnomAD-4.0.0 1.59845E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44005E-05 0
L/V 5554 Ig-39 12 None 0.086 None 0.999 N 0.508 0.229 0.241664281697 gnomAD-4.0.0 1.59846E-06 None None None None I None 0 0 None 0 0 None 0 2.42601E-04 0 0 0
V/I 5648 Ig-40 12 None 0.1061 None 0.37 N 0.335 0.26 0.417208245017 gnomAD-4.0.0 6.85476E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16206E-05 0
V/L 5648 Ig-40 12 rs1451261949 0.4568 0.338 0.9 N 0.483 0.355 0.478755181577 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.66E-05 0 0
V/L 5648 Ig-40 12 rs1451261949 0.4568 0.338 0.9 N 0.483 0.355 0.478755181577 gnomAD-4.0.0 6.85476E-07 None None None None N None 0 0 None 0 0 None 1.87406E-05 0 0 0 0
S/C 5741 Ig-41 12 rs794729614 0.1034 None 0.996 N 0.57 0.275 0.5073929853 gnomAD-4.0.0 2.05619E-06 None None None None N None 0 0 None 0 0 None 0 0 2.7021E-06 0 0
V/A 5834 Ig-42 12 None 0.529 None 0.999 N 0.479 0.656 0.725433469916 gnomAD-4.0.0 1.59165E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8591E-06 0 0
V/I 5834 Ig-42 12 rs727505221 0.1262 -0.763 0.997 N 0.482 0.442 0.731663896529 gnomAD-2.1.1 2.41E-05 None None None None N None 0 0 None 0 5.57E-05 None 6.54E-05 None 0 8.88E-06 3.31895E-04
V/I 5834 Ig-42 12 rs727505221 0.1262 -0.763 0.997 N 0.482 0.442 0.731663896529 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/I 5834 Ig-42 12 rs727505221 0.1262 -0.763 0.997 N 0.482 0.442 0.731663896529 gnomAD-4.0.0 4.95821E-05 None None None None N None 0 0 None 0 2.22916E-05 None 0 1.64582E-04 5.50994E-05 2.19616E-05 1.7613E-04
S/R 5930 Ig-43 12 None 0.903 None 0.994 D 0.405 0.402 0.439763647824 gnomAD-4.0.0 1.20033E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/A 6023 Ig-44 12 rs1037108046 0.2246 -1.575 0.76 N 0.442 0.374 0.549249573952 gnomAD-2.1.1 7.33E-06 None None None None N None 4.18E-05 0 None 0 0 None 0 None 0 8.05E-06 0
V/A 6023 Ig-44 12 rs1037108046 0.2246 -1.575 0.76 N 0.442 0.374 0.549249573952 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
V/A 6023 Ig-44 12 rs1037108046 0.2246 -1.575 0.76 N 0.442 0.374 0.549249573952 gnomAD-4.0.0 2.23812E-05 None None None None N None 1.3369E-05 0 None 0 0 None 0 0 2.71902E-05 0 4.81943E-05
V/F 6023 Ig-44 12 rs2080216835 0.3341 None 0.991 D 0.667 0.637 0.864907916677 gnomAD-4.0.0 6.86678E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01869E-07 0 0
L/M 6117 Ig-45 13 rs2154307656 0.1366 None 0.994 D 0.561 0.239 0.586633458331 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/P 6117 Ig-45 13 None 0.813 None 0.998 D 0.653 0.624 0.863965248906 gnomAD-4.0.0 3.18489E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71886E-06 0 0
V/I 6210 Ig-46 12 rs766360972 0.0993 -0.56 0.63 N 0.491 0.265 0.61403422888 gnomAD-2.1.1 1.07E-05 None None None None N None 1.24059E-04 0 None 0 0 None 0 None 0 0 0
V/I 6210 Ig-46 12 rs766360972 0.0993 -0.56 0.63 N 0.491 0.265 0.61403422888 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20639E-04 0 0 0 0 None 0 0 0 0 0
V/I 6210 Ig-46 12 rs766360972 0.0993 -0.56 0.63 N 0.491 0.265 0.61403422888 gnomAD-4.0.0 6.08971E-06 None None None None N None 1.04836E-04 0 None 0 0 None 0 0 0 0 0
K/E 6492 Ig-49 12 rs781106189 0.1179 -0.366 0.012 N 0.095 0.219 0.247872288689 gnomAD-2.1.1 1.26E-05 None None None None N None 0 0 None 0 0 None 1.04471E-04 None 0 0 0
K/E 6492 Ig-49 12 rs781106189 0.1179 -0.366 0.012 N 0.095 0.219 0.247872288689 gnomAD-4.0.0 1.03148E-05 None None None None N None 0 0 None 0 0 None 0 0 2.70469E-06 1.18092E-04 3.33233E-05
A/T 6585 Ig-50 12 None 0.1471 None 0.576 N 0.343 0.258 0.365892764245 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/N 6772 Ig-52 12 rs765440640 0.2193 -0.674 0.788 N 0.515 0.246 0.348764635752 gnomAD-2.1.1 4.31E-06 None None None None N None 6.88E-05 0 None 0 0 None 0 None 0 0 0
T/N 6772 Ig-52 12 rs765440640 0.2193 -0.674 0.788 N 0.515 0.246 0.348764635752 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/N 6772 Ig-52 12 rs765440640 0.2193 -0.674 0.788 N 0.515 0.246 0.348764635752 gnomAD-4.0.0 1.26378E-06 None None None None N None 1.35752E-05 0 None 0 0 None 0 0 8.60279E-07 0 0
T/S 6772 Ig-52 12 rs765440640 0.1595 -1.156 0.197 N 0.395 0.158 0.148003135375 gnomAD-2.1.1 1.72E-05 None None None None N None 0 0 None 0 0 None 1.47406E-04 None 0 0 0
T/S 6772 Ig-52 12 rs765440640 0.1595 -1.156 0.197 N 0.395 0.158 0.148003135375 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
T/S 6772 Ig-52 12 rs765440640 0.1595 -1.156 0.197 N 0.395 0.158 0.148003135375 gnomAD-4.0.0 4.42321E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.18063E-05 0
V/F 6865 Ig-53 12 None 0.2152 None 0.901 N 0.422 0.522 0.774875236417 gnomAD-4.0.0 6.88996E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.18655E-05 0
V/I 6865 Ig-53 12 rs2154304381 0.0878 None 0.008 D 0.171 0.152 0.328752806141 gnomAD-4.0.0 6.88996E-07 None None None None I None 0 0 None 0 0 None 0 0 9.03566E-07 0 0
G/V 7055 Ig-55 12 rs1189873191 0.1541 -0.078 0.993 N 0.74 0.309 0.708674432205 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
G/V 7055 Ig-55 12 rs1189873191 0.1541 -0.078 0.993 N 0.74 0.309 0.708674432205 gnomAD-4.0.0 4.79138E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29797E-06 0 0
G/W 7055 Ig-55 12 rs375219301 0.4776 -1.106 1.0 N 0.621 0.417 None gnomAD-2.1.1 2.02E-05 None None None None N None 1.94351E-04 2.91E-05 None 0 0 None 0 None 0 0 1.67056E-04
G/W 7055 Ig-55 12 rs375219301 0.4776 -1.106 1.0 N 0.621 0.417 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20604E-04 0 0 0 0 None 0 0 0 0 0
G/W 7055 Ig-55 12 rs375219301 0.4776 -1.106 1.0 N 0.621 0.417 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
G/W 7055 Ig-55 12 rs375219301 0.4776 -1.106 1.0 N 0.621 0.417 None gnomAD-4.0.0 6.81871E-06 None None None None N None 9.33134E-05 3.33622E-05 None 0 0 None 0 0 0 0 3.20318E-05
V/G 7148 Ig-56 12 None 0.2142 None None D 0.367 0.293 0.764626318615 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 7148 Ig-56 12 rs778943017 0.0882 -0.207 None N 0.159 0.205 0.258779203287 gnomAD-2.1.1 1.25E-05 None None None None N None 0 0 None 0 0 None 0 None 0 9.17E-06 3.46141E-04
V/I 7148 Ig-56 12 rs778943017 0.0882 -0.207 None N 0.159 0.205 0.258779203287 gnomAD-4.0.0 8.06975E-06 None None None None N None 0 0 None 0 0 None 0 2.44858E-04 2.89051E-06 0 9.18892E-05
V/A 7241 Ig-57 12 rs1292676739 0.1998 -1.141 0.013 N 0.233 0.171 0.374434639691 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/A 7241 Ig-57 12 rs1292676739 0.1998 -1.141 0.013 N 0.233 0.171 0.374434639691 gnomAD-4.0.0 1.59215E-06 None None None None N None 0 0 None 0 2.77362E-05 None 0 0 0 0 0
V/I 7241 Ig-57 12 rs367854582 0.082 -0.406 0.003 N 0.307 0.127 None gnomAD-2.1.1 6.11E-05 None None None None N None 5.79998E-04 8.51E-05 None 0 0 None 0 None 0 0 0
V/I 7241 Ig-57 12 rs367854582 0.082 -0.406 0.003 N 0.307 0.127 None gnomAD-3.1.2 1.90639E-04 None None None None N None 6.75578E-04 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 7241 Ig-57 12 rs367854582 0.082 -0.406 0.003 N 0.307 0.127 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
V/I 7241 Ig-57 12 rs367854582 0.082 -0.406 0.003 N 0.307 0.127 None gnomAD-4.0.0 3.47095E-05 None None None None N None 6.66578E-04 5.00267E-05 None 0 0 None 0 0 8.47748E-07 0 3.20236E-05
V/L 7241 Ig-57 12 None 0.2616 None 0.068 D 0.449 0.165 0.154104182512 gnomAD-4.0.0 6.8439E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99603E-07 0 0
A/V 7334 Ig-58 12 None 0.095 None 0.095 N 0.215 0.112 0.257292322809 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/P 7430 Ig-59 12 rs1324818657 0.6721 -0.693 0.784 N 0.595 0.322 0.410603549233 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
Q/P 7430 Ig-59 12 rs1324818657 0.6721 -0.693 0.784 N 0.595 0.322 0.410603549233 gnomAD-4.0.0 7.96183E-06 None None None None N None 0 0 None 0 0 None 0 0 0 7.17237E-05 0
V/D 7526 Ig-60 12 None 0.5967 None 0.667 D 0.688 0.62 0.885774903276 gnomAD-4.0.0 1.60858E-06 None None None None N None 0 2.30574E-05 None 0 0 None 0 0 0 0 0
V/F 7526 Ig-60 12 rs754972548 0.2438 -1.521 0.497 D 0.664 0.571 0.779041191306 gnomAD-2.1.1 4.1E-05 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 8.13E-05 0
V/F 7526 Ig-60 12 rs754972548 0.2438 -1.521 0.497 D 0.664 0.571 0.779041191306 gnomAD-3.1.2 5.91E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 8.82E-05 0 0
V/F 7526 Ig-60 12 rs754972548 0.2438 -1.521 0.497 D 0.664 0.571 0.779041191306 gnomAD-4.0.0 7.90152E-05 None None None None N None 4.01273E-05 0 None 0 0 None 0 0 1.05416E-04 0 0
V/L 7619 Ig-61 12 rs770870073 0.1505 0.103 0.007 N 0.193 0.137 0.176091768786 gnomAD-2.1.1 8.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
V/L 7619 Ig-61 12 rs770870073 0.1505 0.103 0.007 N 0.193 0.137 0.176091768786 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 7619 Ig-61 12 rs770870073 0.1505 0.103 0.007 N 0.193 0.137 0.176091768786 gnomAD-4.0.0 1.49484E-05 None None None None N None 0 0 None 0 0 None 0 0 1.8739E-05 0 3.2231E-05
A/T 7713 Ig-62 12 rs778331160 0.0827 -0.887 None N 0.158 0.281 0.223146558224 gnomAD-2.1.1 1.24E-05 None None None None N None 0 0 None 0 0 None 6.91E-05 None 0 9.06E-06 0
A/T 7713 Ig-62 12 rs778331160 0.0827 -0.887 None N 0.158 0.281 0.223146558224 gnomAD-4.0.0 4.82194E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87753E-06 2.931E-05 0
T/P 7806 Ig-63 12 None 0.3824 None 0.906 N 0.399 0.402 0.400468435593 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 7900 Ig-64 12 None 0.4655 None 0.645 N 0.463 0.499 0.67724314777 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/D 7996 Ig-65 12 None 0.3166 None 0.042 N 0.483 0.336 0.488055169367 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 7996 Ig-65 12 None 0.4418 None 0.301 N 0.592 0.296 0.37479162749 gnomAD-4.0.0 6.84356E-07 None None None None I None 0 0 None 0 0 None 0 0 8.997E-07 0 0
A/S 7996 Ig-65 12 rs879233655 0.0948 None None N 0.15 0.148 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
A/S 7996 Ig-65 12 rs879233655 0.0948 None None N 0.15 0.148 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 7996 Ig-65 12 rs879233655 0.0948 None None N 0.15 0.148 None gnomAD-4.0.0 6.19855E-06 None None None None I None 0 0 None 0 0 None 0 0 8.47843E-06 0 0
V/L 8089 Ig-66 12 rs757252230 0.2826 -0.437 0.973 N 0.5 0.524 0.597483089494 gnomAD-2.1.1 3.26E-05 None None None None I None 4.18E-05 0 None 0 0 None 0 None 0 6.34E-05 0
V/L 8089 Ig-66 12 rs757252230 0.2826 -0.437 0.973 N 0.5 0.524 0.597483089494 gnomAD-3.1.2 4.6E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 8.82E-05 0 0
V/L 8089 Ig-66 12 rs757252230 0.2826 -0.437 0.973 N 0.5 0.524 0.597483089494 gnomAD-4.0.0 8.12931E-05 None None None None I None 1.33601E-05 0 None 0 0 None 0 0 1.06047E-04 0 8.01462E-05
V/A 8182 Ig-67 12 None 0.2782 None 0.973 D 0.483 0.493 0.671574616662 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 8275 Ig-68 12 rs771947778 0.0954 -1.281 0.01 N 0.149 0.216 0.300449992093 gnomAD-2.1.1 4.13E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
A/T 8275 Ig-68 12 rs771947778 0.0954 -1.281 0.01 N 0.149 0.216 0.300449992093 gnomAD-4.0.0 1.10167E-05 None None None None I None 0 0 None 0 0 None 0 0 1.17018E-05 3.48554E-05 0
I/T 8560 Ig-71 12 rs727504204 0.0805 None None N 0.085 0.184 0.611125358375 gnomAD-4.0.0 1.38592E-06 None None None None I None 0 0 None 0 0 None 0 0 9.07777E-07 1.19474E-05 0
T/I 8654 Ig-72 12 rs547017929 0.1404 0.213 0.889 N 0.662 0.189 None gnomAD-2.1.1 1.32847E-04 None None None None N None 0 0 None 0 0 None 1.04877E-03 None 0 0 1.66389E-04
T/I 8654 Ig-72 12 rs547017929 0.1404 0.213 0.889 N 0.662 0.189 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.22665E-04 0
T/I 8654 Ig-72 12 rs547017929 0.1404 0.213 0.889 N 0.662 0.189 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
T/I 8654 Ig-72 12 rs547017929 0.1404 0.213 0.889 N 0.662 0.189 None gnomAD-4.0.0 4.58689E-05 None None None None N None 0 0 None 0 0 None 0 0 0 7.47516E-04 9.60738E-05
T/R 8654 Ig-72 12 None 0.3035 None 0.076 D 0.357 0.289 0.473300991676 gnomAD-4.0.0 6.84442E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99633E-07 0 0
V/L 8841 Ig-74 12 rs2154297041 0.385 None 0.962 N 0.455 0.369 0.602294275845 gnomAD-4.0.0 1.59262E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86007E-06 0 0
G/V 8937 Ig-75 12 None 0.175 None 0.704 N 0.519 0.242 0.329540904979 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 9123 Ig-77 12 rs879134187 0.0837 None 0.549 D 0.445 0.385 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 9123 Ig-77 12 rs879134187 0.0837 None 0.549 D 0.445 0.385 None gnomAD-4.0.0 3.71925E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08651E-06 0 0
I/V 9123 Ig-77 12 rs2076812939 0.0617 None 0.001 N 0.107 0.188 0.296329037015 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
I/V 9123 Ig-77 12 rs2076812939 0.0617 None 0.001 N 0.107 0.188 0.296329037015 gnomAD-4.0.0 7.10456E-06 None None None None N None 0 0 None 0 0 None 0 0 6.02462E-06 4.69572E-05 3.40252E-05
V/L 9216 Ig-78 12 rs2076754022 0.4413 None 0.981 N 0.472 0.399 0.593798965771 gnomAD-4.0.0 1.59154E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85889E-06 0 0
E/G 9312 Ig-79 12 None 0.2582 None 0.071 N 0.425 0.229 0.3349148499 gnomAD-4.0.0 1.59332E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86251E-06 0 0
A/T 9408 Ig-80 12 rs767417518 0.0852 -1.35 0.722 None 0.525 0.284 0.366659145958 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65948E-04
A/T 9408 Ig-80 12 rs767417518 0.0852 -1.35 0.722 None 0.525 0.284 0.366659145958 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/T 9408 Ig-80 12 rs767417518 0.0852 -1.35 0.722 None 0.525 0.284 0.366659145958 gnomAD-4.0.0 3.04472E-06 None None None None N None 3.49369E-05 0 None 0 0 None 0 0 1.20491E-06 0 0
V/E 9601 Ig-82 12 rs1436259872 0.3295 -1.397 0.497 None 0.609 0.371 0.550005317886 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
V/E 9601 Ig-82 12 rs1436259872 0.3295 -1.397 0.497 None 0.609 0.371 0.550005317886 gnomAD-4.0.0 2.73761E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59877E-06 0 0
V/M 9601 Ig-82 12 rs1310690220 0.1569 -0.744 0.667 None 0.567 0.358 0.475112344478 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/M 9601 Ig-82 12 rs1310690220 0.1569 -0.744 0.667 None 0.567 0.358 0.475112344478 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
V/I 9709 Ig-83 12 rs369339313 0.1841 -0.419 0.046 None 0.25 0.244 None gnomAD-2.1.1 1.08E-05 None None None None N None 4.17E-05 0 None 0 0 None 0 None 0 1.59E-05 0
V/I 9709 Ig-83 12 rs369339313 0.1841 -0.419 0.046 None 0.25 0.244 None gnomAD-3.1.2 2.63E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 2.94E-05 0 0
V/I 9709 Ig-83 12 rs369339313 0.1841 -0.419 0.046 None 0.25 0.244 None gnomAD-4.0.0 1.55098E-05 None None None None N None 2.67044E-05 0 None 0 0 None 0 0 1.95095E-05 0 0
V/L 9709 Ig-83 12 None 0.846 None 0.76 None 0.423 0.322 0.55973633643 gnomAD-4.0.0 6.85064E-07 None None None None N None 0 0 None 0 2.52105E-05 None 0 0 0 0 0
V/A 9911 Ig-84 12 None 0.627 None 0.948 None 0.48 0.435 0.662052801077 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/F 9911 Ig-84 12 None 0.8055 None 0.999 None 0.737 0.525 0.827634584912 gnomAD-4.0.0 6.85732E-07 None None None None N None 0 0 None 0 0 None 0 0 8.997E-07 0 0
V/L 9911 Ig-84 12 rs2075583653 0.7237 None 0.948 None 0.494 0.378 0.694527089616 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/L 9911 Ig-84 12 rs2075583653 0.7237 None 0.948 None 0.494 0.378 0.694527089616 gnomAD-4.0.0 1.8628E-06 None None None None N None 4.00962E-05 0 None 0 0 None 0 0 0 0 0
L/P 10000 Ig-85 12 rs768379279 0.9605 -1.533 0.989 None 0.56 0.557 0.865652480908 gnomAD-2.1.1 2.41E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.31E-05 0
L/P 10000 Ig-85 12 rs768379279 0.9605 -1.533 0.989 None 0.56 0.557 0.865652480908 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
L/P 10000 Ig-85 12 rs768379279 0.9605 -1.533 0.989 None 0.56 0.557 0.865652480908 gnomAD-4.0.0 9.29481E-06 None None None None N None 0 1.66633E-05 None 0 0 None 0 0 1.18665E-05 0 0
L/F 13694 Ig-87 11 None 0.7751 None 1.0 D 0.749 0.416 0.74495810933 gnomAD-4.0.0 1.59223E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
L/S 13694 Ig-87 11 None 0.9849 None 1.0 D 0.805 0.618 0.796996417136 gnomAD-4.0.0 1.5922E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
V/M 13792 Ig-88 13 rs1445036438 0.6879 None 0.999 N 0.405 0.333 0.42264334713 gnomAD-4.0.0 2.06631E-06 None None None None N None 0 0 None 0 0 None 0 0 2.71256E-06 0 0
I/L 13976 Ig-90 12 rs773772232 0.4576 -0.849 0.041 N 0.382 0.048 0.201204373187 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/L 13976 Ig-90 12 rs773772232 0.4576 -0.849 0.041 N 0.382 0.048 0.201204373187 gnomAD-4.0.0 1.5923E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
I/N 13976 Ig-90 12 None 0.9653 None 0.911 N 0.821 0.311 0.610288044756 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/E 14242 Ig-93 12 None 0.6446 None 0.908 D 0.743 0.467 0.515430650102 gnomAD-4.0.0 1.36917E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79937E-06 0 0
A/G 14242 Ig-93 12 rs769564228 0.0979 -1.497 0.002 N 0.28 0.2 0.273503213844 gnomAD-2.1.1 7.18E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.58E-05 0
A/G 14242 Ig-93 12 rs769564228 0.0979 -1.497 0.002 N 0.28 0.2 0.273503213844 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/G 14242 Ig-93 12 rs769564228 0.0979 -1.497 0.002 N 0.28 0.2 0.273503213844 gnomAD-4.0.0 3.10017E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23909E-06 0 0
A/V 14242 Ig-93 12 rs769564228 0.1777 -0.571 0.908 N 0.64 0.146 0.297718772494 gnomAD-2.1.1 1.08E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.36E-05 0
A/V 14242 Ig-93 12 rs769564228 0.1777 -0.571 0.908 N 0.64 0.146 0.297718772494 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/V 14242 Ig-93 12 rs769564228 0.1777 -0.571 0.908 N 0.64 0.146 0.297718772494 gnomAD-4.0.0 5.58031E-06 None None None None N None 0 0 None 0 0 None 1.56548E-05 0 6.78255E-06 0 0
V/M 14330 Ig-94 12 rs2060028411 0.3777 None 0.005 D 0.441 0.169 0.0611884634855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 14330 Ig-94 12 rs2060028411 0.3777 None 0.005 D 0.441 0.169 0.0611884634855 gnomAD-4.0.0 6.57445E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4708E-05 0 0
V/A 14419 Ig-95 12 None 0.4574 None 0.999 N 0.494 0.606 0.652303537738 gnomAD-4.0.0 1.59267E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
V/I 14419 Ig-95 12 rs529018517 0.1287 -0.576 0.997 D 0.505 0.407 0.812223674915 gnomAD-2.1.1 1.79211E-04 None None None None I None 0 0 None 0 0 None 1.56965E-03 None 0 0 2.8177E-04
V/I 14419 Ig-95 12 rs529018517 0.1287 -0.576 0.997 D 0.505 0.407 0.812223674915 gnomAD-3.1.2 9.21E-05 None None None None I None 0 0 0 0 0 None 0 0 0 2.90216E-03 0
V/I 14419 Ig-95 12 rs529018517 0.1287 -0.576 0.997 D 0.505 0.407 0.812223674915 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 0 0 None None None 3.1E-03 None
V/I 14419 Ig-95 12 rs529018517 0.1287 -0.576 0.997 D 0.505 0.407 0.812223674915 gnomAD-4.0.0 1.04764E-04 None None None None I None 0 0 None 0 0 None 0 0 0 1.80105E-03 8.00512E-05
A/T 14508 Ig-96 12 None 0.1619 None 0.896 N 0.511 0.241 0.329282125956 gnomAD-4.0.0 6.90055E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04156E-07 0 0
V/A 14775 Ig-99 11 None 0.4804 None 0.999 N 0.482 0.638 0.715797810027 gnomAD-4.0.0 1.59311E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86179E-06 0 0
V/L 14775 Ig-99 11 rs540115992 0.656 -0.485 0.999 D 0.513 0.575 0.680116873462 gnomAD-2.1.1 2.82E-05 None None None None N None 0 2.03276E-04 None 0 0 None 0 None 0 0 0
V/L 14775 Ig-99 11 rs540115992 0.656 -0.485 0.999 D 0.513 0.575 0.680116873462 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96464E-04 0 0 0 None 0 0 0 0 0
V/L 14775 Ig-99 11 rs540115992 0.656 -0.485 0.999 D 0.513 0.575 0.680116873462 gnomAD-4.0.0 6.82023E-06 None None None None N None 0 1.83462E-04 None 0 0 None 0 0 0 0 0
V/M 14775 Ig-99 11 rs540115992 0.5571 -0.509 1.0 D 0.73 0.633 0.731815193843 gnomAD-2.1.1 8.94E-05 None None None None N None 8.27E-05 6.23512E-04 None 0 0 None 0 None 0 7.82E-06 0
V/M 14775 Ig-99 11 rs540115992 0.5571 -0.509 1.0 D 0.73 0.633 0.731815193843 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 1.96464E-04 0 0 0 None 0 0 0 0 0
V/M 14775 Ig-99 11 rs540115992 0.5571 -0.509 1.0 D 0.73 0.633 0.731815193843 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
V/M 14775 Ig-99 11 rs540115992 0.5571 -0.509 1.0 D 0.73 0.633 0.731815193843 gnomAD-4.0.0 2.04592E-05 None None None None N None 1.3338E-05 4.66838E-04 None 0 2.23784E-05 None 0 0 2.54387E-06 0 0
V/F 14864 Ig-100 12 rs535221404 0.5525 -1.44 0.983 D 0.717 0.67 0.828855119494 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.72E-05 None 0 0 None 0 None 0 0 0
V/F 14864 Ig-100 12 rs535221404 0.5525 -1.44 0.983 D 0.717 0.67 0.828855119494 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
V/F 14864 Ig-100 12 rs535221404 0.5525 -1.44 0.983 D 0.717 0.67 0.828855119494 gnomAD-4.0.0 2.48072E-06 None None None None N None 0 6.67958E-05 None 0 0 None 0 0 0 0 0
V/I 14864 Ig-100 12 rs535221404 0.1083 -0.648 0.773 D 0.521 0.398 0.672993254785 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66667E-04
V/I 14864 Ig-100 12 rs535221404 0.1083 -0.648 0.773 D 0.521 0.398 0.672993254785 gnomAD-4.0.0 1.36953E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.31763E-05
V/I 15042 Ig-102 12 None 0.1185 None 0.324 N 0.439 0.26 0.625329643188 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
I/V 15131 Ig-103 12 None 0.0792 None None N 0.119 0.186 0.300449992093 gnomAD-4.0.0 4.78689E-06 None None None None I None 0 0 None 0 0 None 0 0 8.59126E-06 0 0
V/M 15219 Ig-104 12 rs765315826 0.2947 -0.654 0.996 D 0.509 0.489 0.666835787278 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
V/M 15219 Ig-104 12 rs765315826 0.2947 -0.654 0.996 D 0.509 0.489 0.666835787278 gnomAD-4.0.0 1.59445E-06 None None None None N None 0 0 None 0 0 None 1.88402E-05 0 0 0 0
T/I 15313 Ig-105 12 rs2058109086 0.3931 None 0.999 N 0.722 0.424 0.48300943003 gnomAD-4.0.0 6.85359E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00487E-07 0 0
V/A 15402 Ig-106 12 rs1559868004 0.7096 -0.948 0.948 N 0.433 0.623 0.690019882811 gnomAD-2.1.1 4.38E-06 None None None None N None 0 0 None 0 0 None 3.99E-05 None 0 0 0
V/A 15402 Ig-106 12 rs1559868004 0.7096 -0.948 0.948 N 0.433 0.623 0.690019882811 gnomAD-4.0.0 5.58645E-06 None None None None N None 0 0 None 0 0 None 0 0 0 9.91105E-05 0
V/I 15402 Ig-106 12 None 0.124 None 0.198 N 0.205 0.22 0.59161276173 gnomAD-4.0.0 3.32775E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.09789E-05 0
V/A 15579 Ig-108 12 None 0.239 None 0.78 N 0.43 0.44 0.545389625809 gnomAD-4.0.0 1.37097E-06 None None None None N None 0 0 None 0 0 None 0 1.92456E-04 9.00293E-07 0 0
V/I 15579 Ig-108 12 rs753144532 0.0882 -0.513 0.026 N 0.215 0.193 0.414281671643 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.67E-05 None 0 None 0 0 0
V/I 15579 Ig-108 12 rs753144532 0.0882 -0.513 0.026 N 0.215 0.193 0.414281671643 gnomAD-4.0.0 1.59837E-06 None None None None N None 0 0 None 0 2.79517E-05 None 0 0 0 0 0
V/I 15974 Ig-109 7 rs1346269011 0.1736 -0.405 0.016 N 0.275 0.076 0.32471235697 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
V/I 15974 Ig-109 7 rs1346269011 0.1736 -0.405 0.016 N 0.275 0.076 0.32471235697 gnomAD-4.0.0 1.36925E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79988E-06 0 0
V/A 16270 Ig-110 9 rs2056979046 0.5436 None 0.122 N 0.229 0.376 0.56713362702 gnomAD-4.0.0 4.78585E-06 None None None None N None 0 0 None 0 8.37848E-05 None 0 0 0 0 0
V/I 16270 Ig-110 9 rs533178407 0.1316 -0.584 0.954 N 0.522 0.347 0.710593507571 gnomAD-2.1.1 3.65E-05 None None None None N None 0 0 None 0 0 None 2.62622E-04 None 0 0 1.6756E-04
V/I 16270 Ig-110 9 rs533178407 0.1316 -0.584 0.954 N 0.522 0.347 0.710593507571 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14079E-04 0
V/I 16270 Ig-110 9 rs533178407 0.1316 -0.584 0.954 N 0.522 0.347 0.710593507571 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
V/I 16270 Ig-110 9 rs533178407 0.1316 -0.584 0.954 N 0.522 0.347 0.710593507571 gnomAD-4.0.0 1.30284E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.86932E-04 6.41293E-05
V/G 16966 Ig-111 12 None 0.6785 None 1.0 D 0.721 0.796 0.899195765859 gnomAD-4.0.0 1.59394E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43377E-05 0
V/I 16966 Ig-111 12 None 0.0977 None 0.997 N 0.481 0.402 0.798506520085 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 17259 Ig-112 9 None 0.4807 None 1.0 D 0.761 0.569 0.686737365345 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 17684 Ig-113 8 rs1456939827 0.1153 None 0.011 N 0.179 0.099 0.602985972322 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 3.88954E-04 None 0 0 0 0 0
I/V 17684 Ig-113 8 rs1456939827 0.1153 None 0.011 N 0.179 0.099 0.602985972322 gnomAD-4.0.0 8.05967E-06 None None None None N None 0 0 None 0 2.90438E-04 None 0 0 0 0 0
C/Y 18390 Ig-115 9 rs759877537 0.557 -1.388 0.794 N 0.695 0.354 0.658123265804 gnomAD-2.1.1 4.04E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
V/F 18696 Ig-116 9 rs1433208414 0.3713 None 0.989 D 0.627 0.621 0.888587291134 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/F 18696 Ig-116 9 rs1433208414 0.3713 None 0.989 D 0.627 0.621 0.888587291134 gnomAD-4.0.0 1.24889E-06 None None None None N None 1.35102E-05 1.73118E-05 None 0 0 None 0 0 0 0 0
V/I 18696 Ig-116 9 None 0.1095 None 0.891 N 0.439 0.279 0.562428738172 gnomAD-4.0.0 6.89932E-07 None None None None N None 0 0 None 0 0 None 0 0 9.03388E-07 0 0
V/A 19104 Ig-117 10 rs776210519 0.7451 -1.915 0.999 N 0.506 0.638 0.816439466794 gnomAD-2.1.1 6.38E-05 None None None None I None 0 0 None 0 0 None 0 None 0 1.29702E-04 0
V/A 19104 Ig-117 10 rs776210519 0.7451 -1.915 0.999 N 0.506 0.638 0.816439466794 gnomAD-3.1.2 2.63E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
V/A 19104 Ig-117 10 rs776210519 0.7451 -1.915 0.999 N 0.506 0.638 0.816439466794 gnomAD-4.0.0 6.41024E-06 None None None None I None 3.38352E-05 0 None 0 0 None 0 0 7.18308E-06 0 0
V/D 19104 Ig-117 10 rs776210519 0.9909 -1.911 1.0 D 0.723 0.834 0.860407132683 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
V/D 19104 Ig-117 10 rs776210519 0.9909 -1.911 1.0 D 0.723 0.834 0.860407132683 gnomAD-4.0.0 1.59257E-06 None None None None I None 0 2.28948E-05 None 0 0 None 0 0 0 0 0
I/V 19398 Ig-118 8 rs375724247 0.0564 None None N 0.155 0.079 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 19398 Ig-118 8 rs375724247 0.0564 None None N 0.155 0.079 None gnomAD-4.0.0 3.04509E-06 None None None None I None 3.49467E-05 0 None 0 0 None 0 0 1.20497E-06 0 0
I/M 19798 Ig-119 9 rs772501285 0.221 -0.71 0.966 D 0.456 0.366 0.551838628669 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/M 19798 Ig-119 9 rs772501285 0.221 -0.71 0.966 D 0.456 0.366 0.551838628669 gnomAD-4.0.0 1.59211E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
I/N 19798 Ig-119 9 None 0.8181 None 0.989 N 0.529 0.576 0.789076550681 gnomAD-4.0.0 1.59213E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
I/T 19798 Ig-119 9 None 0.6932 None 0.801 N 0.351 0.358 0.737149919481 gnomAD-4.0.0 1.59213E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02499E-05
V/E 20090 Ig-120 11 None 0.947 None 1.0 D 0.671 0.764 0.893265043611 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 20488 Ig-121 10 rs778745953 0.6431 -1.875 0.999 D 0.501 0.584 0.754719756649 gnomAD-2.1.1 4.58E-06 None None None None I None 0 0 None 0 5.76E-05 None 0 None 0 0 0
V/A 20488 Ig-121 10 rs778745953 0.6431 -1.875 0.999 D 0.501 0.584 0.754719756649 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.94024E-04 None 0 0 0 0 0
V/A 20488 Ig-121 10 rs778745953 0.6431 -1.875 0.999 D 0.501 0.584 0.754719756649 gnomAD-4.0.0 2.6823E-06 None None None None I None 0 0 None 0 4.89165E-05 None 0 0 0 0 0
V/L 20488 Ig-121 10 None 0.549 None 0.999 N 0.518 0.444 0.728599915167 gnomAD-4.0.0 7.00948E-07 None None None None I None 0 0 None 0 0 None 0 0 9.13314E-07 0 0
V/M 20488 Ig-121 10 rs77957535 0.4503 -0.798 1.0 D 0.746 0.486 None gnomAD-2.1.1 2.74E-05 None None None None I None 0 3.23E-05 None 0 5.76E-05 None 1.34096E-04 None 5.15E-05 0 0
V/M 20488 Ig-121 10 rs77957535 0.4503 -0.798 1.0 D 0.746 0.486 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 3.87597E-04 None 0 0 1.47E-05 0 4.78011E-04
V/M 20488 Ig-121 10 rs77957535 0.4503 -0.798 1.0 D 0.746 0.486 None gnomAD-4.0.0 1.39352E-05 None None None None I None 0 5.30279E-05 None 0 8.98473E-05 None 1.60036E-05 0 7.73951E-06 3.58551E-05 3.28364E-05
V/F 20781 Ig-122 13 None 0.5991 None 1.0 D 0.568 0.748 0.895171775139 gnomAD-4.0.0 1.59198E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
V/M 21186 Ig-123 10 None 0.6261 None 0.942 D 0.547 0.604 0.695291002561 gnomAD-4.0.0 6.85778E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16417E-05 0
I/M 21478 Ig-124 10 None 0.1742 None 0.988 D 0.529 0.417 0.410868550352 gnomAD-4.0.0 1.59992E-06 None None None None N None 0 0 None 0 0 None 1.88509E-05 0 0 0 0
I/V 21478 Ig-124 10 None 0.0723 None 0.061 N 0.137 0.154 0.404453528171 gnomAD-4.0.0 6.85842E-06 None None None None N None 0 0 None 0 0 None 0 0 7.20627E-06 1.16869E-05 1.66063E-05
L/I 22273 Ig-126 9 None 0.1912 None 0.698 N 0.463 0.073 0.514072065251 gnomAD-4.0.0 1.5946E-06 None None None None I None 5.67344E-05 0 None 0 0 None 0 0 0 0 0
A/D 22562 Ig-127 3 rs776797528 0.9888 -0.517 1.0 N 0.675 0.567 0.829526042196 gnomAD-2.1.1 1.65E-05 None None None None I None 0 0 None 2.06186E-04 0 None 0 None 0 1.8E-05 0
A/D 22562 Ig-127 3 rs776797528 0.9888 -0.517 1.0 N 0.675 0.567 0.829526042196 gnomAD-4.0.0 1.13188E-05 None None None None I None 0 0 None 4.83465E-05 0 None 0 0 1.73709E-05 0 0
A/P 22562 Ig-127 3 rs747962210 0.8777 -0.535 1.0 N 0.669 0.632 0.6731056941 gnomAD-2.1.1 4.15E-06 None None None None I None 0 0 None 0 5.65E-05 None 0 None 0 0 0
A/P 22562 Ig-127 3 rs747962210 0.8777 -0.535 1.0 N 0.669 0.632 0.6731056941 gnomAD-4.0.0 1.62293E-06 None None None None I None 0 0 None 0 2.7908E-05 None 0 0 0 0 0
V/I 23356 Ig-129 12 rs1207836218 0.143 -0.547 0.025 D 0.308 0.235 0.600020119452 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/I 23356 Ig-129 12 rs1207836218 0.143 -0.547 0.025 D 0.308 0.235 0.600020119452 gnomAD-4.0.0 6.36697E-06 None None None None I None 0 4.5731E-05 None 0 0 None 0 0 5.71857E-06 0 0
A/V 23645 Ig-130 9 rs757143081 0.2317 -0.299 0.884 N 0.365 0.277 0.49590494691 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.67392E-04
A/V 23645 Ig-130 9 rs757143081 0.2317 -0.299 0.884 N 0.365 0.277 0.49590494691 gnomAD-4.0.0 1.5938E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02773E-05
L/S 24041 Ig-131 13 rs1245486609 0.546 -1.74 0.497 N 0.52 0.451 0.803963018184 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/S 24041 Ig-131 13 rs1245486609 0.546 -1.74 0.497 N 0.52 0.451 0.803963018184 gnomAD-4.0.0 1.59218E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
I/L 24440 Ig-132 10 rs373311221 0.1193 -1.038 0.006 N 0.219 0.196 0.533131753447 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/L 24440 Ig-132 10 rs373311221 0.1193 -1.038 0.006 N 0.219 0.196 0.533131753447 gnomAD-4.0.0 4.79049E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29733E-06 0 0
I/T 24440 Ig-132 10 rs370931683 0.7308 -2.072 0.822 N 0.607 0.404 None gnomAD-2.1.1 3.94E-05 None None None None I None 3.72147E-04 0 None 0 0 None 0 None 4E-05 7.84E-06 0
I/T 24440 Ig-132 10 rs370931683 0.7308 -2.072 0.822 N 0.607 0.404 None gnomAD-3.1.2 7.89E-05 None None None None I None 2.89603E-04 0 0 0 0 None 0 0 0 0 0
I/T 24440 Ig-132 10 rs370931683 0.7308 -2.072 0.822 N 0.607 0.404 None 1000 genomes 3.99361E-04 None None None None I None 1.5E-03 0 None None 0 0 None None None 0 None
I/T 24440 Ig-132 10 rs370931683 0.7308 -2.072 0.822 N 0.607 0.404 None gnomAD-4.0.0 1.36355E-05 None None None None I None 2.53313E-04 0 None 0 0 None 1.56216E-05 0 0 0 3.20164E-05
I/V 24440 Ig-132 10 rs373311221 0.0805 -1.398 0.014 N 0.227 0.094 0.520854953866 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 1.11869E-04 None 0 None 0 0 0
I/V 24440 Ig-132 10 rs373311221 0.0805 -1.398 0.014 N 0.227 0.094 0.520854953866 gnomAD-4.0.0 4.10614E-06 None None None None I None 0 0 None 0 0 None 0 3.47222E-04 3.59847E-06 0 0
V/A 24727 Ig-133 12 rs769619709 0.484 -1.379 0.999 N 0.475 0.616 0.767380901185 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/A 24727 Ig-133 12 rs769619709 0.484 -1.379 0.999 N 0.475 0.616 0.767380901185 gnomAD-4.0.0 3.18468E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71906E-06 0 0
V/I 24727 Ig-133 12 rs773070815 0.1165 -0.301 0.997 N 0.445 0.422 0.825722815492 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/I 24727 Ig-133 12 rs773070815 0.1165 -0.301 0.997 N 0.445 0.422 0.825722815492 gnomAD-4.0.0 6.84411E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99596E-07 0 0
V/L 24727 Ig-133 12 rs773070815 0.5543 None 0.997 N 0.49 0.495 0.755182339457 gnomAD-4.0.0 2.73764E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59838E-06 0 0
V/A 25123 Ig-134 13 rs1456861699 0.4431 None 0.22 D 0.445 0.369 0.647442735181 gnomAD-4.0.0 2.73714E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59826E-06 0 0
I/T 25522 Ig-135 9 rs372963832 0.495 -1.125 0.684 N 0.387 0.364 None gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
I/T 25522 Ig-135 9 rs372963832 0.495 -1.125 0.684 N 0.387 0.364 None gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 25522 Ig-135 9 rs372963832 0.495 -1.125 0.684 N 0.387 0.364 None gnomAD-4.0.0 1.67399E-05 None None None None I None 1.3359E-05 0 None 0 0 None 0 0 2.11957E-05 0 1.60226E-05
I/V 25522 Ig-135 9 rs1403999176 0.0702 None 0.003 N 0.173 0.06 0.557405679382 gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.56E-05 0 0 0 None 0 0 1.47E-05 0 4.78011E-04
I/V 25522 Ig-135 9 rs1403999176 0.0702 None 0.003 N 0.173 0.06 0.557405679382 gnomAD-4.0.0 5.12934E-06 None None None None I None 0 1.69745E-05 None 0 2.43487E-05 None 0 0 2.39459E-06 0 2.84803E-05
V/A 25809 Ig-136 12 rs367819941 0.3725 -1.555 0.645 N 0.428 0.405 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 25809 Ig-136 12 rs367819941 0.3725 -1.555 0.645 N 0.428 0.405 None gnomAD-4.0.0 1.59225E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4334E-05 0
V/A 26205 Ig-137 13 rs398124456 0.5868 None 0.939 D 0.459 0.574 0.69793306553 gnomAD-4.0.0 1.59498E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86261E-06 0 0
V/G 26205 Ig-137 13 None 0.7783 None 0.997 D 0.687 0.821 0.928572533926 gnomAD-4.0.0 1.59498E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86261E-06 0 0
V/I 26604 Ig-138 11 rs190407944 0.0928 -0.564 0.067 N 0.321 0.218 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/I 26604 Ig-138 11 rs190407944 0.0928 -0.564 0.067 N 0.321 0.218 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 26604 Ig-138 11 rs190407944 0.0928 -0.564 0.067 N 0.321 0.218 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
V/I 26604 Ig-138 11 rs190407944 0.0928 -0.564 0.067 N 0.321 0.218 None gnomAD-4.0.0 1.23944E-06 None None None None N None 1.33298E-05 0 None 0 0 None 0 0 8.47688E-07 0 0
V/L 26604 Ig-138 11 rs190407944 0.4243 -0.582 0.618 N 0.483 0.416 0.656879027039 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/L 26604 Ig-138 11 rs190407944 0.4243 -0.582 0.618 N 0.483 0.416 0.656879027039 gnomAD-4.0.0 6.84273E-07 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 0 0 0
V/I 27287 Ig-140 10 rs1704823668 0.0781 None 0.997 N 0.505 0.466 0.846003560123 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 27287 Ig-140 10 rs1704823668 0.0781 None 0.997 N 0.505 0.466 0.846003560123 gnomAD-4.0.0 1.85963E-06 None None None None N None 4.00502E-05 0 None 0 0 None 0 0 0 0 0
L/V 27687 Ig-141 12 None 0.0872 None 0.001 N 0.127 0.077 0.483224754729 gnomAD-4.0.0 6.84239E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
V/A 28369 Ig-143 12 None 0.4515 None 0.052 D 0.404 0.321 0.620047664876 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/D 28369 Ig-143 12 rs1703451641 0.9121 None 0.484 D 0.543 0.644 0.848468935609 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/D 28369 Ig-143 12 rs1703451641 0.9121 None 0.484 D 0.543 0.644 0.848468935609 gnomAD-4.0.0 2.02995E-06 None None None None I None 0 0 None 0 0 None 0 0 2.4099E-06 0 0
V/A 28766 Ig-144 12 rs754113086 0.6491 -1.311 0.999 N 0.489 0.681 0.735764439114 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/A 28766 Ig-144 12 rs754113086 0.6491 -1.311 0.999 N 0.489 0.681 0.735764439114 gnomAD-4.0.0 6.85577E-07 None None None None N None 0 2.23794E-05 None 0 0 None 0 0 0 0 0
V/G 28766 Ig-144 12 None 0.8278 None 1.0 D 0.695 0.816 0.935219820968 gnomAD-4.0.0 6.85577E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
Y/H 29452 Ig-146 9 rs763288364 0.2946 -0.137 0.028 N 0.338 0.225 0.301455362545 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 2.23189E-04 None 0 None 0 0 0
Y/H 29452 Ig-146 9 rs763288364 0.2946 -0.137 0.028 N 0.338 0.225 0.301455362545 gnomAD-4.0.0 1.4322E-05 None None None None I None 0 0 None 0 2.49709E-04 None 0 0 0 0 0
A/D 29851 Ig-147 10 rs774885355 0.9456 -1.432 1.0 N 0.676 0.623 0.806978627759 gnomAD-2.1.1 8.27E-06 None None None None N None 0 0 None 0 0 None 6.59E-05 None 0 0 0
A/D 29851 Ig-147 10 rs774885355 0.9456 -1.432 1.0 N 0.676 0.623 0.806978627759 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/D 29851 Ig-147 10 rs774885355 0.9456 -1.432 1.0 N 0.676 0.623 0.806978627759 gnomAD-4.0.0 8.74292E-06 None None None None N None 0 1.66867E-05 None 0 0 None 0 0 2.55085E-06 9.90426E-05 1.60705E-05
A/V 29851 Ig-147 10 rs774885355 0.1709 None 0.884 N 0.39 0.166 0.415313616471 gnomAD-4.0.0 5.52057E-06 None None None None N None 0 0 None 0 0 None 0 0 7.21983E-06 0 0
V/L 30143 Ig-148 12 rs1287481084 0.5361 -0.312 0.997 D 0.502 0.526 0.741963092889 gnomAD-2.1.1 4.04E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/L 30143 Ig-148 12 rs1287481084 0.5361 -0.312 0.997 D 0.502 0.526 0.741963092889 gnomAD-4.0.0 6.85653E-07 None None None None I None 2.99168E-05 0 None 0 0 None 0 0 0 0 0
I/T 30538 Ig-149 7 rs1231839154 0.3701 None 0.324 D 0.391 0.462 0.684537292048 gnomAD-4.0.0 1.20035E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
I/V 30538 Ig-149 7 None 0.0759 None 0.001 N 0.157 0.078 0.340753184043 gnomAD-4.0.0 1.59192E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85938E-06 0 0
I/L 31627 Ig-152 7 None 0.1834 None 0.58 N 0.41 0.197 0.552367828057 gnomAD-4.0.0 1.59161E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85873E-06 0 0
I/M 31627 Ig-152 7 None 0.2429 None 0.991 N 0.491 0.44 0.603382761471 gnomAD-4.0.0 1.36855E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.319E-05 0
I/T 31627 Ig-152 7 rs751714990 0.7488 -1.557 0.939 N 0.518 0.565 0.748615457965 gnomAD-2.1.1 2.02E-05 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 3.58E-05 0
I/T 31627 Ig-152 7 rs751714990 0.7488 -1.557 0.939 N 0.518 0.565 0.748615457965 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 31627 Ig-152 7 rs751714990 0.7488 -1.557 0.939 N 0.518 0.565 0.748615457965 gnomAD-4.0.0 3.2227E-05 None None None None I None 5.34074E-05 1.66722E-05 None 0 0 None 0 0 3.56015E-05 0 8.00641E-05
I/L 32026 Ig-153 10 None 0.0865 None None N 0.112 0.214 0.0954503805726 gnomAD-4.0.0 1.59198E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43324E-05 0
I/T 32026 Ig-153 10 rs998031380 0.5315 None 0.012 N 0.441 0.333 0.677706433072 gnomAD-4.0.0 1.3687E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79925E-06 0 0
V/A 32716 Ig-155 9 None 0.5851 None 0.999 N 0.497 0.577 0.737036055105 gnomAD-4.0.0 1.59128E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
V/I 32716 Ig-155 9 None 0.112 None 0.997 D 0.502 0.372 0.748681091053 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85843E-06 0 0
T/A 33112 Ig-156 12 rs761837150 0.0697 -0.989 0.288 N 0.486 0.225 0.252162846088 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
T/A 33112 Ig-156 12 rs761837150 0.0697 -0.989 0.288 N 0.486 0.225 0.252162846088 gnomAD-4.0.0 1.5927E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43382E-05 0
T/K 33112 Ig-156 12 rs374883160 0.5589 -0.985 0.976 N 0.748 0.515 None gnomAD-2.1.1 3.23E-05 None None None None N None 6.48E-05 2.91E-05 None 0 0 None 0 None 4.66E-05 3.57E-05 1.66667E-04
T/K 33112 Ig-156 12 rs374883160 0.5589 -0.985 0.976 N 0.748 0.515 None gnomAD-3.1.2 3.94E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 5.88E-05 0 4.78011E-04
T/K 33112 Ig-156 12 rs374883160 0.5589 -0.985 0.976 N 0.748 0.515 None gnomAD-4.0.0 4.02945E-05 None None None None N None 2.67123E-05 3.33656E-05 None 0 0 None 0 0 4.57827E-05 1.09859E-05 9.60922E-05
G/R 33208 Ig-157 6 None 0.7102 None 0.922 N 0.581 0.371 0.52540932818 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 33507 Ig-158 12 None 0.1705 None 0.42 N 0.281 0.211 0.539656846532 gnomAD-4.0.0 3.18523E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86038E-06 1.4341E-05 0
A/V 33607 Ig-159 12 None 0.4457 None 1.0 N 0.62 0.351 0.5630262602 gnomAD-4.0.0 1.59605E-06 None None None None N None 0 0 None 0 0 None 1.91953E-05 0 0 0 0
G/V 34147 Ig-160 11 None 0.2536 None None N 0.33 0.125 0.208000267992 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/G 34269 Ig-161 12 None 0.3231 None 0.698 N 0.465 0.394 0.491523185611 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 34269 Ig-161 12 rs1690251007 0.9756 None 0.99 N 0.654 0.7 0.655169154632 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/P 34269 Ig-161 12 rs1690251007 0.9756 None 0.99 N 0.654 0.7 0.655169154632 gnomAD-4.0.0 6.56961E-06 None None None None N None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
C/F 34374 Ig-162 12 rs368493317 0.8465 -1.166 0.995 N 0.554 0.511 0.81253044437 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
C/F 34374 Ig-162 12 rs368493317 0.8465 -1.166 0.995 N 0.554 0.511 0.81253044437 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/F 34374 Ig-162 12 rs368493317 0.8465 -1.166 0.995 N 0.554 0.511 0.81253044437 gnomAD-4.0.0 1.61174E-05 None None None None N None 0 0 None 0 0 None 0 0 2.03507E-05 0 3.20318E-05
V/I 34953 Ig-163 12 rs776593972 0.1485 -0.802 0.543 N 0.237 0.217 0.453962894745 gnomAD-2.1.1 4.01E-05 None None None None N None 0 2.89687E-04 None 0 0 None 0 None 0 0 0
V/I 34953 Ig-163 12 rs776593972 0.1485 -0.802 0.543 N 0.237 0.217 0.453962894745 gnomAD-4.0.0 8.20969E-06 None None None None N None 0 2.45975E-04 None 0 0 None 0 0 8.994E-07 0 0
V/L 34953 Ig-163 12 rs776593972 0.7317 -0.804 0.948 N 0.445 0.461 0.528761452848 gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
V/L 34953 Ig-163 12 rs776593972 0.7317 -0.804 0.948 N 0.445 0.461 0.528761452848 gnomAD-4.0.0 1.36828E-06 None None None None N None 0 4.47227E-05 None 0 0 None 0 0 0 0 0
V/F 35140 Ig-164 12 None 0.3118 None 0.978 D 0.726 0.563 0.863341754641 gnomAD-4.0.0 6.84137E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99394E-07 0 0
V/I 35140 Ig-164 12 rs371893623 0.0833 -0.428 0.081 D 0.321 0.245 None gnomAD-2.1.1 3.21E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 6.24E-05 0
V/I 35140 Ig-164 12 rs371893623 0.0833 -0.428 0.081 D 0.321 0.245 None gnomAD-3.1.2 5.91E-05 None None None None N None 1.2068E-04 0 0 0 0 None 0 0 5.88E-05 0 0
V/I 35140 Ig-164 12 rs371893623 0.0833 -0.428 0.081 D 0.321 0.245 None gnomAD-4.0.0 4.52332E-05 None None None None N None 1.06798E-04 0 None 0 0 None 0 0 5.0852E-05 1.09786E-05 6.40348E-05
V/A 35431 Ig-166 12 rs770923321 0.1349 -1.206 None N 0.111 0.159 0.409533910539 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 35431 Ig-166 12 rs770923321 0.1349 -1.206 None N 0.111 0.159 0.409533910539 gnomAD-4.0.0 1.59101E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
V/L 35431 Ig-166 12 rs774220321 0.1847 -0.463 0.002 N 0.334 0.099 0.281381271821 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
V/L 35431 Ig-166 12 rs774220321 0.1847 -0.463 0.002 N 0.334 0.099 0.281381271821 gnomAD-4.0.0 1.59102E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85763E-06 0 0
I/M 35618 Ig-167 12 rs1687755639 0.1415 None 0.81 N 0.606 0.22 0.512366387742 gnomAD-4.0.0 3.18176E-06 None None None None N None 0 4.57247E-05 None 0 0 None 0 0 0 0 0
I/R 35618 Ig-167 12 None 0.5238 None 0.896 N 0.684 0.598 0.814266610154 gnomAD-4.0.0 6.84139E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99399E-07 0 0
I/T 35618 Ig-167 12 rs1575194805 0.4251 None 0.016 N 0.392 0.368 0.673447929508 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 35618 Ig-167 12 rs1575194805 0.4251 None 0.016 N 0.392 0.368 0.673447929508 gnomAD-4.0.0 2.47842E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39015E-06 0 0
I/L 35908 Ig-169 12 None 0.2977 None 0.993 N 0.305 0.326 0.48286525802 gnomAD-4.0.0 8.92808E-06 None None None -1.01(OBSL1) -1.08(OBSCN) N None 0 0 None 0 0 None 0 0 1.1734E-05 0 0
I/M 35908 Ig-169 12 None 0.2032 None 1.0 N 0.585 0.492 0.406806705197 gnomAD-4.0.0 2.05723E-06 None None None -1.264(OBSL1) -1.082(OBSCN) N None 0 0 None 0 0 None 0 0 2.7043E-06 0 0
I/T 35908 Ig-169 12 rs769141222 0.3905 -3.038 1.0 N 0.55 0.507 None gnomAD-2.1.1 2.87E-05 None None None -0.937(OBSL1) -0.198(OBSCN) N None 0 0 None 0 0 None 0 None 0 6.29E-05 0
I/T 35908 Ig-169 12 rs769141222 0.3905 -3.038 1.0 N 0.55 0.507 None gnomAD-3.1.2 1.31E-05 None None None -0.937(OBSL1) -0.198(OBSCN) N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 35908 Ig-169 12 rs769141222 0.3905 -3.038 1.0 N 0.55 0.507 None gnomAD-4.0.0 6.20981E-05 None None None -0.937(OBSL1) -0.198(OBSCN) N None 0 0 None 0 0 None 0 0 8.49408E-05 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.