Structural position:

  • Domain Type: Ig
  • Aligned Position: 173
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand G

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/D 94 Ig-1 89 None 0.2308 None 0.993 N 0.494 0.335 0.483374165343 gnomAD-4.0.0 6.84081E-07 None None None -0.674(TCAP) N None 0 0 None 0 2.51927E-05 None 0 0 0 0 0
E/D 190 Ig-2 87 rs753196873 0.3673 -0.643 0.001 N 0.352 0.086 0.241078983079 gnomAD-2.1.1 7.96E-06 None None None -1.078(TCAP) N None 6.15E-05 0 None 0 0 None 0 None 0 8.8E-06 0
E/D 190 Ig-2 87 rs753196873 0.3673 -0.643 0.001 N 0.352 0.086 0.241078983079 gnomAD-3.1.2 5.91E-05 None None None -1.078(TCAP) N None 9.65E-05 0 0 0 0 None 0 0 7.35E-05 0 0
E/D 190 Ig-2 87 rs753196873 0.3673 -0.643 0.001 N 0.352 0.086 0.241078983079 gnomAD-4.0.0 1.36305E-05 None None None -1.078(TCAP) N None 6.67254E-05 0 None 0 0 None 0 0 1.44069E-05 0 0
E/Q 190 Ig-2 87 None 0.3235 None 0.306 N 0.315 0.262 0.241664281697 gnomAD-4.0.0 1.59053E-06 None None None -1.563(TCAP) N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
Y/C 1029 Ig-3 87 rs774126306 0.7499 -0.302 0.999 N 0.738 0.535 None gnomAD-2.1.1 1.42E-05 None None None None N None 1.20163E-04 0 None 0 0 None 3.27E-05 None 0 0 0
Y/C 1029 Ig-3 87 rs774126306 0.7499 -0.302 0.999 N 0.738 0.535 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
Y/C 1029 Ig-3 87 rs774126306 0.7499 -0.302 0.999 N 0.738 0.535 None gnomAD-4.0.0 6.81985E-06 None None None None N None 9.34554E-05 0 None 0 0 None 0 0 1.69512E-06 2.19703E-05 0
Y/S 1029 Ig-3 87 rs774126306 0.6949 -1.214 0.982 N 0.717 0.48 0.681924071509 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
Y/S 1029 Ig-3 87 rs774126306 0.6949 -1.214 0.982 N 0.717 0.48 0.681924071509 gnomAD-4.0.0 6.84583E-07 None None None None N None 0 0 None 0 2.52054E-05 None 0 0 0 0 0
S/F 1170 Ig-4 89 rs759110931 0.2372 -0.653 0.999 N 0.795 0.393 0.64938254418 gnomAD-2.1.1 1.99E-05 None None None None I None 0 0 None 0 0 None 1.63356E-04 None 0 0 0
S/F 1170 Ig-4 89 rs759110931 0.2372 -0.653 0.999 N 0.795 0.393 0.64938254418 gnomAD-4.0.0 5.47318E-06 None None None None I None 0 0 None 0 0 None 0 0 0 9.27472E-05 0
S/P 1170 Ig-4 89 rs1387634284 0.7385 -0.124 0.999 N 0.743 0.418 0.355450299083 gnomAD-2.1.1 6.37E-05 None None None None I None 2.29568E-04 0 None 0 0 None 0 None 0 0 0
S/P 1170 Ig-4 89 rs1387634284 0.7385 -0.124 0.999 N 0.743 0.418 0.355450299083 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
S/P 1170 Ig-4 89 rs1387634284 0.7385 -0.124 0.999 N 0.743 0.418 0.355450299083 gnomAD-4.0.0 1.97091E-05 None None None None I None 7.23624E-05 0 None 0 0 None 0 0 0 0 0
K/E 1378 Ig-5 88 None 0.9527 None 0.999 N 0.615 0.488 0.435152311215 gnomAD-4.0.0 1.59089E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85714E-06 0 0
I/V 1544 Ig-6 88 rs72647877 0.0685 -0.587 0.001 N 0.167 0.065 None gnomAD-2.1.1 5.63032E-03 None None None None N None 3.44035E-02 4.38671E-03 None 3.36752E-02 0 None 6.86454E-04 None 3.99E-05 1.23988E-03 6.55875E-03
I/V 1544 Ig-6 88 rs72647877 0.0685 -0.587 0.001 N 0.167 0.065 None gnomAD-3.1.2 1.16702E-02 None None None None N None 3.49146E-02 6.87173E-03 0 3.88825E-02 0 None 0 9.49367E-03 9.26089E-04 6.21118E-04 9.57854E-03
I/V 1544 Ig-6 88 rs72647877 0.0685 -0.587 0.001 N 0.167 0.065 None 1000 genomes 1.19808E-02 None None None None N None 4.39E-02 2.9E-03 None None 0 0 None None None 0 None
I/V 1544 Ig-6 88 rs72647877 0.0685 -0.587 0.001 N 0.167 0.065 None gnomAD-4.0.0 3.45281E-03 None None None None N None 3.6533E-02 5.48406E-03 None 3.51061E-02 0 None 0 1.23844E-02 7.86533E-04 7.1369E-04 6.32222E-03
K/E 1644 Ig-7 89 rs2092286862 0.968 None 0.961 N 0.617 0.544 0.324986149311 gnomAD-4.0.0 1.59208E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85845E-06 0 0
T/I 1791 Ig-8 89 rs1393058360 0.5449 None 1.0 D 0.825 0.561 0.603952565061 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 1791 Ig-8 89 rs1393058360 0.5449 None 1.0 D 0.825 0.561 0.603952565061 gnomAD-4.0.0 6.57307E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
K/E 2259 Ig-11 86 None 0.2725 None 0.961 N 0.593 0.355 0.341934017632 gnomAD-4.0.0 2.05276E-06 None None None None N None 0 0 None 0 2.52245E-05 None 0 0 1.79882E-06 0 0
K/Q 2259 Ig-11 86 None 0.1551 None 0.961 N 0.631 0.319 0.244539031024 gnomAD-4.0.0 6.84252E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99408E-07 0 0
N/D 2527 Ig-14 83 rs773079394 0.1227 -0.801 None N 0.193 0.107 0.104622674875 gnomAD-2.1.1 7.09E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 7.77E-06 0
N/D 2527 Ig-14 83 rs773079394 0.1227 -0.801 None N 0.193 0.107 0.104622674875 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/D 2527 Ig-14 83 rs773079394 0.1227 -0.801 None N 0.193 0.107 0.104622674875 gnomAD-4.0.0 2.56138E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39191E-06 1.34002E-05 0
K/N 2614 Ig-15 82 rs535026241 0.1922 -0.744 0.175 N 0.399 0.075 0.112648838833 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
K/N 2614 Ig-15 82 rs535026241 0.1922 -0.744 0.175 N 0.399 0.075 0.112648838833 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92308E-04 None 0 0 0 0 0
K/N 2614 Ig-15 82 rs535026241 0.1922 -0.744 0.175 N 0.399 0.075 0.112648838833 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
K/N 2614 Ig-15 82 rs535026241 0.1922 -0.744 0.175 N 0.399 0.075 0.112648838833 gnomAD-4.0.0 6.56478E-06 None None None None N None 0 0 None 0 1.92753E-04 None 0 0 0 0 0
K/N 2701 Ig-16 81 rs750526009 0.2284 0.044 0.002 N 0.147 0.065 0.154104182512 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
K/N 2701 Ig-16 81 rs750526009 0.2284 0.044 0.002 N 0.147 0.065 0.154104182512 gnomAD-4.0.0 1.59076E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
K/T 2701 Ig-16 81 rs556548772 0.1145 -0.2 0.549 N 0.511 0.138 0.286465849087 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
K/E 2876 Ig-18 82 None 0.4241 None 0.959 N 0.557 0.325 0.317378411342 gnomAD-4.0.0 6.84061E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9929E-07 0 0
K/Q 2876 Ig-18 82 None 0.1999 None 0.996 N 0.617 0.338 0.223847106136 gnomAD-4.0.0 6.84061E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
K/N 3139 Ig-21 82 rs1346392116 0.0754 -0.06 None N 0.116 0.063 0.0138822411134 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
K/N 3139 Ig-21 82 rs1346392116 0.0754 -0.06 None N 0.116 0.063 0.0138822411134 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 4.47207E-05 None 0 0 None 0 0 0 0 0
K/Q 3139 Ig-21 82 None 0.088 None None N 0.1 0.124 0.0482279557977 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
T/I 3230 Ig-22 84 None 0.2097 None 0.012 N 0.294 0.182 0.200317383148 gnomAD-4.0.0 1.20273E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31513E-06 0 0
T/N 3230 Ig-22 84 None 0.2319 None 0.022 N 0.193 0.131 0.139678290688 gnomAD-4.0.0 1.20273E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31513E-06 0 0
N/H 3430 Ig-24 86 rs376029089 0.0688 -0.97 0.295 N 0.469 0.11 None gnomAD-2.1.1 1.99E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.4E-05 0
N/H 3430 Ig-24 86 rs376029089 0.0688 -0.97 0.295 N 0.469 0.11 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
N/H 3430 Ig-24 86 rs376029089 0.0688 -0.97 0.295 N 0.469 0.11 None gnomAD-4.0.0 4.0894E-05 None None None None N None 0 1.6665E-05 None 0 0 None 0 0 5.50875E-05 0 0
N/S 3430 Ig-24 86 None 0.0592 None None N 0.129 0.107 0.0138822411134 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 3553 Ig-25 89 rs770418018 0.1287 -0.28 None None None 0.081 None gnomAD-2.1.1 7.56E-06 None None None None N None 4.16E-05 0 None 0 0 None 0 None 0 8.2E-06 0
T/I 3553 Ig-25 89 rs770418018 0.1287 -0.28 None None None 0.081 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 3553 Ig-25 89 rs770418018 0.1287 -0.28 None None None 0.081 None gnomAD-4.0.0 1.89115E-06 None None None None N None 1.348E-05 0 None 0 0 None 0 0 1.71863E-06 0 0
Y/C 3906 Ig-27 87 rs375020177 0.1804 -0.029 None N 0.361 0.194 None gnomAD-2.1.1 1.07E-05 None None None None I None 1.23998E-04 0 None 0 0 None 0 None 0 0 0
Y/C 3906 Ig-27 87 rs375020177 0.1804 -0.029 None N 0.361 0.194 None gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
Y/C 3906 Ig-27 87 rs375020177 0.1804 -0.029 None N 0.361 0.194 None gnomAD-4.0.0 4.33767E-06 None None None None I None 4.00416E-05 0 None 0 0 None 0 0 0 3.29359E-05 1.60092E-05
E/G 4025 Ig-28 88 rs1452131866 0.2887 None 0.505 D 0.705 0.487 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 4025 Ig-28 88 rs1452131866 0.2887 None 0.505 D 0.705 0.487 None gnomAD-4.0.0 2.56281E-06 None None None None N None 1.6905E-05 0 None 0 0 None 0 0 2.39277E-06 0 0
T/I 4786 Ig-30 87 None 0.1201 None 0.473 N 0.499 0.245 0.518421792786 gnomAD-4.0.0 1.59275E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
T/R 4786 Ig-30 87 rs752484250 0.1072 -0.08 0.473 N 0.55 0.282 0.655901375025 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/R 4786 Ig-30 87 rs752484250 0.1072 -0.08 0.473 N 0.55 0.282 0.655901375025 gnomAD-4.0.0 4.77824E-06 None None None None I None 0 0 None 0 0 None 0 0 8.5858E-06 0 0
E/D 4881 Ig-31 87 rs781644443 0.1818 -0.728 0.996 N 0.45 0.332 0.459370960843 gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.35E-05 0
E/D 4881 Ig-31 87 rs781644443 0.1818 -0.728 0.996 N 0.45 0.332 0.459370960843 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 0 0
E/D 4881 Ig-31 87 rs781644443 0.1818 -0.728 0.996 N 0.45 0.332 0.459370960843 gnomAD-4.0.0 2.29299E-05 None None None None I None 0 0 None 0 0 None 0 0 3.13617E-05 0 0
E/G 4881 Ig-31 87 None 0.2617 None 0.999 N 0.767 0.657 0.623711697247 gnomAD-4.0.0 1.59152E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85824E-06 0 0
E/Q 4881 Ig-31 87 rs756371735 0.1643 -0.297 0.957 N 0.259 0.305 0.363751660372 gnomAD-4.0.0 3.60099E-06 None None None None I None 0 0 None 0 0 None 0 0 3.93753E-06 0 0
E/V 4881 Ig-31 87 rs2081343515 0.3605 None 0.999 N 0.817 0.634 0.678242657409 gnomAD-4.0.0 3.18303E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71647E-06 0 0
E/G 5068 Ig-33 88 None 0.2599 None 0.92 N 0.555 0.404 0.580704020645 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 5161 Ig-34 87 rs1205352955 0.0961 0.163 0.201 N 0.564 0.299 None gnomAD-2.1.1 4.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.11E-06 0
T/I 5161 Ig-34 87 rs1205352955 0.0961 0.163 0.201 N 0.564 0.299 None gnomAD-4.0.0 2.0775E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81574E-06 0 1.67768E-05
T/N 5161 Ig-34 87 None 0.0809 None 0.379 N 0.543 0.255 0.532311620844 gnomAD-4.0.0 6.92501E-07 None None None None N None 0 0 None 0 0 None 0 0 9.07871E-07 0 0
E/K 5254 Ig-35 87 rs867275748 0.1198 None 0.016 N 0.187 0.259 0.245660935333 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 5254 Ig-35 87 rs867275748 0.1198 None 0.016 N 0.187 0.259 0.245660935333 gnomAD-4.0.0 6.57125E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
E/Q 5254 Ig-35 87 rs867275748 0.1149 -0.128 0.549 N 0.564 0.241 0.321672782286 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/Q 5254 Ig-35 87 rs867275748 0.1149 -0.128 0.549 N 0.564 0.241 0.321672782286 gnomAD-4.0.0 1.59662E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87137E-06 0 0
T/A 5347 Ig-36 87 None 0.0796 None 0.454 D 0.423 0.146 0.345175991111 gnomAD-4.0.0 8.40225E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
A/S 5443 Ig-37 87 None 0.0816 None 0.454 N 0.509 0.17 0.221734844693 gnomAD-4.0.0 2.05559E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.48821E-05 0
N/K 5536 Ig-38 87 rs1386348152 0.1585 0.491 None N 0.161 0.121 0.168933306366 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
N/K 5536 Ig-38 87 rs1386348152 0.1585 0.491 None N 0.161 0.121 0.168933306366 gnomAD-4.0.0 1.60937E-06 None None None None N None 0 0 None 0 2.78458E-05 None 0 0 0 0 0
N/S 5536 Ig-38 87 rs1380672169 0.0676 -0.175 0.012 N 0.347 0.099 0.193865811164 gnomAD-2.1.1 4.07E-06 None None None None N None 0 2.95E-05 None 0 0 None 0 None 0 0 0
N/S 5536 Ig-38 87 rs1380672169 0.0676 -0.175 0.012 N 0.347 0.099 0.193865811164 gnomAD-4.0.0 1.6095E-06 None None None None N None 0 2.32288E-05 None 0 0 None 0 0 0 0 0
I/T 5630 Ig-39 88 rs2080640128 0.083 None None N 0.147 0.164 0.661077055835 gnomAD-4.0.0 2.75152E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80748E-06 2.34439E-05 0
R/T 5723 Ig-40 87 rs2080550527 0.0788 None 0.081 N 0.348 0.211 0.296329037015 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/T 5723 Ig-40 87 rs2080550527 0.0788 None 0.081 N 0.348 0.211 0.296329037015 gnomAD-4.0.0 6.57056E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47007E-05 0 0
R/I 5909 Ig-42 87 rs2080369871 0.104 None 0.003 N 0.345 0.129 0.598143334274 gnomAD-4.0.0 1.61471E-06 None None None None N None 0 0 None 0 0 None 0 0 2.90097E-06 0 0
H/D 6005 Ig-43 87 None 0.1525 None 0.025 N 0.423 0.207 0.198526703765 gnomAD-4.0.0 3.44502E-06 None None None None N None 0 0 None 0 0 None 0 0 4.52744E-06 0 0
H/N 6005 Ig-43 87 rs1241109741 0.0779 -0.319 0.001 N 0.079 0.066 0.16115917748 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
H/N 6005 Ig-43 87 rs1241109741 0.0779 -0.319 0.001 N 0.079 0.066 0.16115917748 gnomAD-4.0.0 5.51203E-06 None None None None N None 0 0 None 0 0 None 0 0 7.24391E-06 0 0
H/Q 6005 Ig-43 87 rs1213230929 0.1158 -0.106 0.202 N 0.419 0.144 0.149567049428 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.38E-05 None 0 0 0
H/Q 6005 Ig-43 87 rs1213230929 0.1158 -0.106 0.202 N 0.419 0.144 0.149567049428 gnomAD-4.0.0 4.85572E-06 None None None None N None 0 0 None 0 0 None 3.77117E-05 0 0 1.45645E-05 0
H/R 6005 Ig-43 87 rs1560786611 0.1043 None 0.202 N 0.391 0.2 0.319402600006 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
H/R 6005 Ig-43 87 rs1560786611 0.1043 None 0.202 N 0.391 0.2 0.319402600006 gnomAD-4.0.0 3.23652E-06 None None None None N None 0 0 None 0 0 None 0 0 2.92189E-06 1.45688E-05 0
T/A 6098 Ig-44 87 rs727505140 0.0737 -1.055 0.004 N 0.263 0.12 0.165133752707 gnomAD-2.1.1 4.05E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
T/A 6098 Ig-44 87 rs727505140 0.0737 -1.055 0.004 N 0.263 0.12 0.165133752707 gnomAD-3.1.2 1.39E-05 None None None None N None 5.26E-05 0 0 0 0 None 0 0 0 0 0
T/A 6098 Ig-44 87 rs727505140 0.0737 -1.055 0.004 N 0.263 0.12 0.165133752707 gnomAD-4.0.0 3.89601E-06 None None None None N None 5.3984E-05 0 None 0 0 None 0 0 0 0 0
T/I 6098 Ig-44 87 rs765693409 0.1176 -0.33 0.497 D 0.743 0.279 0.48505662038 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/I 6098 Ig-44 87 rs765693409 0.1176 -0.33 0.497 D 0.743 0.279 0.48505662038 gnomAD-4.0.0 3.20101E-06 None None None None N None 0 0 None 0 0 None 0 0 5.75298E-06 0 0
T/S 6098 Ig-44 87 rs765693409 0.0817 None 0.001 N 0.239 0.082 0.148003135375 gnomAD-4.0.0 1.60051E-06 None None None None N None 5.70972E-05 0 None 0 0 None 0 0 0 0 0
E/K 6192 Ig-45 88 rs1457411847 0.141 -0.082 0.939 N 0.569 0.297 0.342168650903 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 6192 Ig-45 88 rs1457411847 0.141 -0.082 0.939 N 0.569 0.297 0.342168650903 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 6192 Ig-45 88 rs1457411847 0.141 -0.082 0.939 N 0.569 0.297 0.342168650903 gnomAD-4.0.0 1.31441E-05 None None None None N None 0 0 None 0 0 None 0 0 2.94048E-05 0 0
R/I 6285 Ig-46 87 None 0.1246 None 0.171 N 0.591 0.15 0.501624679856 gnomAD-4.0.0 6.85758E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01164E-07 0 0
R/S 6285 Ig-46 87 None 0.1985 None 0.012 N 0.496 0.147 0.104622674875 gnomAD-4.0.0 1.59963E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44163E-05 0
R/T 6285 Ig-46 87 rs2079958809 0.0841 None None N 0.331 0.179 0.360565625551 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/T 6285 Ig-46 87 rs2079958809 0.0841 None None N 0.331 0.179 0.360565625551 gnomAD-4.0.0 7.4516E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01893E-05 0 0
Y/C 6471 Ig-48 87 None 0.1124 None 0.873 N 0.519 0.282 0.637405007395 gnomAD-4.0.0 2.05747E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70393E-06 0 0
I/S 6567 Ig-49 87 None 0.2809 None 0.029 N 0.253 0.301 0.737299269881 gnomAD-4.0.0 7.01308E-07 None None None None N None 0 0 None 0 0 None 0 0 9.13604E-07 0 0
I/T 6567 Ig-49 87 rs1355956536 0.2433 -0.918 0.003 N 0.19 0.235 0.719045985532 gnomAD-2.1.1 4.52E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.75E-06 0
I/T 6567 Ig-49 87 rs1355956536 0.2433 -0.918 0.003 N 0.19 0.235 0.719045985532 gnomAD-4.0.0 2.80523E-06 None None None None N None 0 0 None 0 2.54881E-05 None 0 3.60231E-04 9.13604E-07 0 0
I/V 6567 Ig-49 87 rs1415509567 0.0901 -0.718 0.001 N 0.112 0.074 0.453962894745 gnomAD-2.1.1 4.5E-06 None None None None N None 6.69E-05 0 None 0 0 None 0 None 0 0 0
I/V 6567 Ig-49 87 rs1415509567 0.0901 -0.718 0.001 N 0.112 0.074 0.453962894745 gnomAD-4.0.0 1.40212E-06 None None None None N None 3.10116E-05 0 None 0 0 None 0 0 9.13417E-07 0 0
M/I 6660 Ig-50 87 None 0.2147 None 0.002 N 0.321 0.038 0.270889551736 gnomAD-4.0.0 1.40711E-06 None None None None N None 0 2.60078E-05 None 0 0 None 0 0 9.14875E-07 0 0
M/L 6660 Ig-50 87 rs780339252 0.1113 -0.123 0.001 N 0.227 0.076 0.371157983038 gnomAD-2.1.1 4.46E-06 None None None None N None 0 0 None 0 0 None 0 None 4.94E-05 0 0
M/L 6660 Ig-50 87 rs780339252 0.1113 -0.123 0.001 N 0.227 0.076 0.371157983038 gnomAD-4.0.0 5.06049E-06 None None None None N None 0 0 None 0 0 None 1.91747E-05 0 6.00348E-06 0 0
M/V 6660 Ig-50 87 rs780339252 0.0654 -0.502 None N 0.088 0.138 0.202086224978 gnomAD-2.1.1 4.46E-06 None None None None N None 0 0 None 0 0 None 4.06E-05 None 0 0 0
M/V 6660 Ig-50 87 rs780339252 0.0654 -0.502 None N 0.088 0.138 0.202086224978 gnomAD-4.0.0 1.68683E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.58856E-05 0
K/E 6754 Ig-51 88 rs397517494 0.1571 None 0.959 N 0.451 0.221 0.333154297509 gnomAD-4.0.0 4.91921E-06 None None None None N None 0 0 None 0 0 None 0 0 6.42164E-06 0 0
T/S 6847 Ig-52 87 rs1162932422 0.0825 -1.055 None N 0.216 0.066 0.0806252709748 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/S 6847 Ig-52 87 rs1162932422 0.0825 -1.055 None N 0.216 0.066 0.0806252709748 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 6847 Ig-52 87 rs1162932422 0.0825 -1.055 None N 0.216 0.066 0.0806252709748 gnomAD-4.0.0 2.60029E-06 None None None None N None 0 0 None 0 0 None 0 0 4.86386E-06 0 0
V/E 7034 Ig-54 87 rs1409920305 0.14 -1.264 0.042 N 0.489 0.259 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
V/E 7034 Ig-54 87 rs1409920305 0.14 -1.264 0.042 N 0.489 0.259 None gnomAD-4.0.0 1.59352E-06 None None None None N None 5.67472E-05 0 None 0 0 None 0 0 0 0 0
V/L 7130 Ig-55 87 rs373905235 0.093 -0.385 None N 0.113 0.075 0.143124449307 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/L 7130 Ig-55 87 rs373905235 0.093 -0.385 None N 0.113 0.075 0.143124449307 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/L 7130 Ig-55 87 rs373905235 0.093 -0.385 None N 0.113 0.075 0.143124449307 gnomAD-4.0.0 2.48313E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39586E-06 0 0
V/M 7130 Ig-55 87 None 0.0831 None 0.002 N 0.255 0.158 0.166414681773 gnomAD-4.0.0 6.85555E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01E-07 0 0
R/C 7223 Ig-56 87 rs1156609638 0.0919 None 0.985 D 0.467 0.327 0.663301836877 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
R/C 7223 Ig-56 87 rs1156609638 0.0919 None 0.985 D 0.467 0.327 0.663301836877 gnomAD-4.0.0 4.34194E-06 None None None None N None 1.33565E-05 3.34001E-05 None 0 0 None 0 0 2.54452E-06 0 1.60308E-05
R/H 7223 Ig-56 87 rs138853909 0.0571 -1.707 0.004 N 0.145 0.069 None gnomAD-2.1.1 5.82411E-04 None None None None N None 1.98643E-03 9.68716E-04 None 1.76125E-03 0 None 0 None 4.03E-05 4.32329E-04 8.51305E-04
R/H 7223 Ig-56 87 rs138853909 0.0571 -1.707 0.004 N 0.145 0.069 None gnomAD-3.1.2 9.33547E-04 None None None None N None 2.14862E-03 1.3113E-03 0 1.72911E-03 0 None 0 0 3.67582E-04 0 9.57854E-04
R/H 7223 Ig-56 87 rs138853909 0.0571 -1.707 0.004 N 0.145 0.069 None 1000 genomes 9.98403E-04 None None None None N None 1.5E-03 2.9E-03 None None 0 1E-03 None None None 0 None
R/H 7223 Ig-56 87 rs138853909 0.0571 -1.707 0.004 N 0.145 0.069 None gnomAD-4.0.0 3.27005E-04 None None None None N None 2.01516E-03 9.6977E-04 None 1.59376E-03 0 None 1.56455E-05 1.48908E-03 1.8581E-04 1.10244E-05 6.57409E-04
L/R 7316 Ig-57 87 rs745745237 0.0926 0.191 0.272 N 0.562 0.164 0.505640481493 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
L/R 7316 Ig-57 87 rs745745237 0.0926 0.191 0.272 N 0.562 0.164 0.505640481493 gnomAD-4.0.0 6.36799E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14379E-05 0 0
L/V 7316 Ig-57 87 None 0.0643 None None N 0.18 0.128 0.229264304666 gnomAD-4.0.0 6.84339E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99586E-07 0 0
R/G 7505 Ig-59 87 rs372826489 0.2654 -0.979 0.425 N 0.461 0.351 None gnomAD-2.1.1 8.65E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 3.57015E-04
R/G 7505 Ig-59 87 rs372826489 0.2654 -0.979 0.425 N 0.461 0.351 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/G 7505 Ig-59 87 rs372826489 0.2654 -0.979 0.425 N 0.461 0.351 None gnomAD-4.0.0 6.27575E-06 None None None None N None 1.34608E-05 3.44566E-05 None 0 0 None 0 0 4.27275E-06 0 3.24633E-05
R/K 7505 Ig-59 87 None 0.0826 None 0.002 N 0.182 0.124 0.20549828249 gnomAD-4.0.0 1.38868E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81537E-06 0 0
R/S 7505 Ig-59 87 rs1444059423 0.3642 -0.736 0.065 N 0.239 0.228 0.136095386433 gnomAD-2.1.1 4.35E-06 None None None None N None 0 0 None 0 0 None 3.94E-05 None 0 0 0
R/S 7505 Ig-59 87 rs1444059423 0.3642 -0.736 0.065 N 0.239 0.228 0.136095386433 gnomAD-4.0.0 1.64859E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.54412E-05 0
Q/P 7601 Ig-60 87 None 0.1438 None 0.619 N 0.566 0.362 0.434934176536 gnomAD-4.0.0 6.86339E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01296E-07 0 0
A/E 7695 Ig-61 88 rs201003628 0.2407 None 0.017 N 0.21 0.25 0.475741759771 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/E 7695 Ig-61 88 rs201003628 0.2407 None 0.017 N 0.21 0.25 0.475741759771 gnomAD-4.0.0 6.57376E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
A/S 7695 Ig-61 88 rs748347572 0.0846 -0.277 0.007 N 0.159 0.079 0.253205268125 gnomAD-2.1.1 8.13E-06 None None None None N None 0 0 None 0 0 None 6.63E-05 None 0 0 0
A/S 7695 Ig-61 88 rs748347572 0.0846 -0.277 0.007 N 0.159 0.079 0.253205268125 gnomAD-4.0.0 3.46658E-06 None None None None N None 0 0 None 0 0 None 0 0 9.11246E-07 4.74305E-05 0
A/V 7695 Ig-61 88 rs201003628 0.0927 None 0.774 N 0.513 0.255 0.541557034822 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 7695 Ig-61 88 rs201003628 0.0927 None 0.774 N 0.513 0.255 0.541557034822 gnomAD-4.0.0 2.51075E-06 None None None None N None 0 0 None 0 0 None 0 0 1.71724E-06 1.12526E-05 1.62612E-05
S/F 7788 Ig-62 87 rs749160569 0.0914 -0.75 0.204 N 0.562 0.109 0.515603885326 gnomAD-2.1.1 2.87E-05 None None None None N None 0 2.26835E-04 None 0 0 None 0 None 0 0 0
S/F 7788 Ig-62 87 rs749160569 0.0914 -0.75 0.204 N 0.562 0.109 0.515603885326 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/F 7788 Ig-62 87 rs749160569 0.0914 -0.75 0.204 N 0.562 0.109 0.515603885326 gnomAD-4.0.0 6.20211E-06 None None None None N None 0 1.50291E-04 None 0 0 None 0 0 0 0 1.60277E-05
S/C 7975 Ig-64 87 rs2078029519 0.1734 None 0.999 N 0.663 0.46 0.77112915265 gnomAD-4.0.0 2.06075E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80574E-06 0 1.66312E-05
S/F 7975 Ig-64 87 None 0.1908 None 0.996 N 0.688 0.421 0.823965795647 gnomAD-4.0.0 6.86917E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02869E-07 0 0
H/D 8164 Ig-66 87 rs367916657 0.2295 -0.678 0.002 N 0.181 0.324 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
H/D 8164 Ig-66 87 rs367916657 0.2295 -0.678 0.002 N 0.181 0.324 None gnomAD-4.0.0 2.73731E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59842E-06 0 0
H/Q 8164 Ig-66 87 None 0.1315 None 0.023 N 0.181 0.219 0.104622674875 gnomAD-4.0.0 6.84376E-06 None None None None N None 5.97764E-05 0 None 0 0 None 0 0 7.19722E-06 0 0
H/Y 8164 Ig-66 87 None 0.1081 None 0.917 D 0.465 0.278 0.487277728379 gnomAD-4.0.0 1.36866E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79921E-06 0 0
L/V 8257 Ig-67 87 rs371322658 0.0744 -0.799 None N 0.181 0.083 None gnomAD-2.1.1 2.86E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.27E-05 0
L/V 8257 Ig-67 87 rs371322658 0.0744 -0.799 None N 0.181 0.083 None gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 0 0 8.82E-05 0 0
L/V 8257 Ig-67 87 rs371322658 0.0744 -0.799 None N 0.181 0.083 None gnomAD-4.0.0 3.09921E-05 None None None None N None 0 0 None 0 0 None 0 0 4.2389E-05 0 0
V/A 8350 Ig-68 87 rs915984764 0.1679 None 0.174 N 0.251 0.208 0.439339381091 gnomAD-4.0.0 2.0553E-06 None None None None I None 0 0 None 0 0 None 0 1.73853E-04 9.00722E-07 1.16071E-05 0
V/M 8350 Ig-68 87 None 0.1106 None 0.916 N 0.545 0.207 0.417586769301 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
V/M 8350 Ig-68 87 None 0.1106 None 0.916 N 0.545 0.207 0.417586769301 gnomAD-4.0.0 6.5722E-06 None None None None I None 0 0 None 0 1.92456E-04 None 0 0 0 0 0
K/E 8446 Ig-69 87 None 0.2629 None 0.996 N 0.565 0.255 0.30212335484 gnomAD-4.0.0 1.61293E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4579E-05 0
Q/H 8542 Ig-70 87 rs2562832 0.1086 -0.631 None N 0.12 0.149 None gnomAD-2.1.1 3.8209E-02 None None None None N None 5.25184E-03 4.11918E-02 None 2.6285E-02 2.08513E-01 None 8.40888E-03 None 5.02373E-02 2.36813E-02 3.20531E-02
Q/H 8542 Ig-70 87 rs2562832 0.1086 -0.631 None N 0.12 0.149 None gnomAD-3.1.2 2.59822E-02 None None None None N None 5.06634E-03 2.67986E-02 3.07018E-02 2.93948E-02 1.90789E-01 None 4.72909E-02 6.32911E-03 2.35687E-02 1.20133E-02 2.53589E-02
Q/H 8542 Ig-70 87 rs2562832 0.1086 -0.631 None N 0.12 0.149 None 1000 genomes 5.13179E-02 None None None None N None 1.5E-03 2.74E-02 None None 1.964E-01 2.88E-02 None None None 9.2E-03 None
Q/H 8542 Ig-70 87 rs2562832 0.1086 -0.631 None N 0.12 0.149 None gnomAD-4.0.0 2.73129E-02 None None None None N None 4.69584E-03 3.59919E-02 None 2.53743E-02 1.90868E-01 None 5.06979E-02 9.93049E-03 2.23139E-02 9.47257E-03 2.7727E-02
Q/P 8542 Ig-70 87 None 0.1347 None None D None 0.299 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/A 8636 Ig-71 88 rs1448059327 0.068 -0.887 None N 0.137 0.069 0.0884992946249 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
S/A 8636 Ig-71 88 rs1448059327 0.068 -0.887 None N 0.137 0.069 0.0884992946249 gnomAD-4.0.0 1.59608E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87054E-06 0 0
S/T 8636 Ig-71 88 rs1448059327 0.0812 -0.403 None N 0.147 0.089 0.0806252709748 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/T 8636 Ig-71 88 rs1448059327 0.0812 -0.403 None N 0.147 0.089 0.0806252709748 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 8636 Ig-71 88 rs1448059327 0.0812 -0.403 None N 0.147 0.089 0.0806252709748 gnomAD-4.0.0 3.85262E-06 None None None None N None 0 0 None 0 0 None 0 0 7.20458E-06 0 0
S/F 8729 Ig-72 87 rs1429923693 0.0848 -0.737 0.062 N 0.408 0.141 0.316198179892 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.36E-05 None 0 0 0
S/F 8729 Ig-72 87 rs1429923693 0.0848 -0.737 0.062 N 0.408 0.141 0.316198179892 gnomAD-4.0.0 1.60083E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4497E-05 0
T/K 8823 Ig-73 88 rs368151971 0.1354 -0.326 0.002 N 0.166 0.229 0.0986583533028 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
T/K 8823 Ig-73 88 rs368151971 0.1354 -0.326 0.002 N 0.166 0.229 0.0986583533028 gnomAD-4.0.0 6.84809E-07 None None None None N None 0 0 None 0 2.52054E-05 None 0 0 0 0 0
T/M 8823 Ig-73 88 rs368151971 0.0667 -0.109 0.186 D 0.267 0.156 None gnomAD-2.1.1 2.01E-05 None None None None N None 1.29266E-04 0 None 0 0 None 0 None 0 2.67E-05 0
T/M 8823 Ig-73 88 rs368151971 0.0667 -0.109 0.186 D 0.267 0.156 None gnomAD-3.1.2 5.92E-05 None None None None N None 7.24E-05 6.55E-05 0 0 1.92753E-04 None 0 0 5.88E-05 0 0
T/M 8823 Ig-73 88 rs368151971 0.0667 -0.109 0.186 D 0.267 0.156 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
T/M 8823 Ig-73 88 rs368151971 0.0667 -0.109 0.186 D 0.267 0.156 None gnomAD-4.0.0 1.98452E-05 None None None None N None 8.00598E-05 1.66756E-05 None 0 2.22965E-05 None 0 1.6518E-04 1.52711E-05 0 8.00641E-05
T/R 8823 Ig-73 88 None 0.1095 None 0.604 N 0.561 0.195 0.345632371893 gnomAD-4.0.0 6.84809E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00333E-07 0 0
P/S 9012 Ig-75 87 rs765386562 0.0676 None None N 0.154 0.115 0.0920862733494 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
H/R 9105 Ig-76 87 None 0.0766 None None N 0.16 0.112 0.154104182512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Y 9105 Ig-76 87 rs771109303 0.0978 0.794 0.065 N 0.457 0.091 0.278968121808 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
H/Y 9105 Ig-76 87 rs771109303 0.0978 0.794 0.065 N 0.457 0.091 0.278968121808 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30873E-04 0 0 0 None 0 0 0 0 0
H/Y 9105 Ig-76 87 rs771109303 0.0978 0.794 0.065 N 0.457 0.091 0.278968121808 gnomAD-4.0.0 8.97128E-06 None None None None N None 0 1.18628E-04 None 0 0 None 0 0 0 0 0
Q/E 9198 Ig-77 87 rs72648995 0.0696 -0.02 0.159 N 0.195 0.098 0.236278675362 gnomAD-2.1.1 1.16658E-04 None None None None N None 0 8.40677E-04 None 0 0 None 0 None 0 0 0
Q/E 9198 Ig-77 87 rs72648995 0.0696 -0.02 0.159 N 0.195 0.098 0.236278675362 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96412E-04 0 0 0 None 0 0 0 0 0
Q/E 9198 Ig-77 87 rs72648995 0.0696 -0.02 0.159 N 0.195 0.098 0.236278675362 gnomAD-4.0.0 4.7414E-05 None None None None N None 0 5.932E-04 None 0 0 None 0 0 0 0 5.68861E-05
Q/R 9198 Ig-77 87 rs368297438 0.0869 0.217 0.178 N 0.317 0.107 None gnomAD-2.1.1 8.21E-05 None None None None N None 9.50728E-04 0 None 0 0 None 0 None 0 0 0
Q/R 9198 Ig-77 87 rs368297438 0.0869 0.217 0.178 N 0.317 0.107 None gnomAD-3.1.2 2.36568E-04 None None None None N None 8.44228E-04 6.55E-05 0 0 0 None 0 0 0 0 0
Q/R 9198 Ig-77 87 rs368297438 0.0869 0.217 0.178 N 0.317 0.107 None gnomAD-4.0.0 3.65685E-05 None None None None N None 7.47524E-04 3.33478E-05 None 0 0 None 0 0 0 0 1.60113E-05
F/S 9291 Ig-78 87 rs754982924 0.1145 -0.986 0.003 N 0.204 0.222 0.607559715422 gnomAD-2.1.1 1.25E-05 None None None None I None 0 2.99E-05 None 0 0 None 0 None 0 1.84E-05 0
F/S 9291 Ig-78 87 rs754982924 0.1145 -0.986 0.003 N 0.204 0.222 0.607559715422 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/S 9291 Ig-78 87 rs754982924 0.1145 -0.986 0.003 N 0.204 0.222 0.607559715422 gnomAD-4.0.0 1.04382E-05 None None None None I None 0 1.72849E-05 None 0 0 None 0 0 1.21922E-05 0 5.78737E-05
R/S 9387 Ig-79 87 None 0.3672 None 0.012 None 0.405 0.077 0.18274738541 gnomAD-4.0.0 1.65249E-06 None None None None N None 0 0 None 0 0 None 0 0 2.95098E-06 0 0
Q/R 9483 Ig-80 87 None 0.1186 None 0.326 None 0.366 0.139 0.24896430686 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
S/L 9580 Ig-81 88 rs375212459 0.1936 -0.13 0.379 None 0.587 0.428 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
S/L 9580 Ig-81 88 rs375212459 0.1936 -0.13 0.379 None 0.587 0.428 None gnomAD-4.0.0 1.61279E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.05792E-05
E/D 10070 Ig-85 82 None 0.1137 None 0.001 None 0.167 0.112 0.0401082797425 gnomAD-4.0.0 6.84234E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99433E-07 0 0
E/D 10164 Ig-86 87 rs1064797276 0.8835 -0.862 0.999 None 0.486 0.131 0.267755039894 gnomAD-2.1.1 4.01E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/D 10164 Ig-86 87 rs1064797276 0.8835 -0.862 0.999 None 0.486 0.131 0.267755039894 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 10164 Ig-86 87 rs1064797276 0.8835 -0.862 0.999 None 0.486 0.131 0.267755039894 gnomAD-4.0.0 6.84134E-07 None None None None N None 0 2.23594E-05 None 0 0 None 0 0 0 0 0
C/G 13865 Ig-88 86 None 0.2207 None 0.27 N 0.441 0.145 0.533808175679 gnomAD-4.0.0 6.90824E-07 None None None None N None 0 0 None 0 0 None 0 0 9.06498E-07 0 0
C/S 13865 Ig-88 86 None 0.1879 None 0.01 N 0.337 0.123 0.384252928164 gnomAD-4.0.0 1.63059E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.09617E-05
R/P 14134 Ig-91 81 rs764083952 0.7876 0.067 0.232 N 0.579 0.135 0.188950314367 gnomAD-2.1.1 8.3E-06 None None None None I None 0 0 None 0 0 None 3.46E-05 None 0 9.1E-06 0
R/P 14134 Ig-91 81 rs764083952 0.7876 0.067 0.232 N 0.579 0.135 0.188950314367 gnomAD-4.0.0 2.06359E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.37074E-05 1.66572E-05
R/Q 14134 Ig-91 81 rs764083952 0.0805 0.224 None N 0.215 0.04 0.0401082797425 gnomAD-2.1.1 2.94E-05 None None None None I None 0 9.03E-05 None 0 1.58865E-04 None 0 None 0 1.6E-05 0
R/Q 14134 Ig-91 81 rs764083952 0.0805 0.224 None N 0.215 0.04 0.0401082797425 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 1.94024E-04 None 0 0 1.47E-05 0 0
R/Q 14134 Ig-91 81 rs764083952 0.0805 0.224 None N 0.215 0.04 0.0401082797425 gnomAD-4.0.0 1.86824E-05 None None None None I None 1.34902E-05 5.20743E-05 None 3.4009E-05 6.72013E-05 None 0 1.65399E-04 1.52811E-05 1.12128E-05 3.21947E-05
R/W 14134 Ig-91 81 rs753341792 0.2301 -0.455 0.964 N 0.505 0.145 0.235038932564 gnomAD-2.1.1 4.12E-05 None None None None I None 0 1.81796E-04 None 0 1.14312E-04 None 0 None 0 1.81E-05 0
R/W 14134 Ig-91 81 rs753341792 0.2301 -0.455 0.964 N 0.505 0.145 0.235038932564 gnomAD-3.1.2 4.61E-05 None None None None I None 0 1.97031E-04 0 0 0 None 0 0 4.41E-05 2.07727E-04 0
R/W 14134 Ig-91 81 rs753341792 0.2301 -0.455 0.964 N 0.505 0.145 0.235038932564 gnomAD-4.0.0 2.67458E-05 None None None None I None 0 1.54353E-04 None 0 4.47989E-05 None 0 0 2.54581E-05 2.22955E-05 0
Q/H 14223 Ig-92 82 rs371287021 0.0903 -0.645 None N 0.131 0.081 0.0138822411134 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
N/D 14311 Ig-93 81 rs767640666 0.1131 -0.516 0.101 N 0.435 0.112 0.0954503805726 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/D 14311 Ig-93 81 rs767640666 0.1131 -0.516 0.101 N 0.435 0.112 0.0954503805726 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
N/D 14311 Ig-93 81 rs767640666 0.1131 -0.516 0.101 N 0.435 0.112 0.0954503805726 gnomAD-4.0.0 4.95874E-06 None None None None N None 0 0 None 0 0 None 0 0 0 7.6869E-05 1.60185E-05
N/H 14311 Ig-93 81 rs767640666 0.1012 None 0.794 N 0.523 0.15 0.12205267543 gnomAD-4.0.0 6.84396E-07 None None None None N None 2.99043E-05 0 None 0 0 None 0 0 0 0 0
N/K 14311 Ig-93 81 None 0.2022 None 0.002 N 0.146 0.049 0.0138822411134 gnomAD-4.0.0 6.84396E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9963E-07 0 0
N/H 14400 Ig-94 82 rs775820574 0.0974 -0.853 0.481 N 0.636 0.182 0.170165803431 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
N/H 14400 Ig-94 82 rs775820574 0.0974 -0.853 0.481 N 0.636 0.182 0.170165803431 gnomAD-4.0.0 3.18763E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72367E-06 0 0
N/K 14400 Ig-94 82 None 0.1896 None None N 0.267 0.11 0.0482279557977 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 14400 Ig-94 82 rs772475209 0.0847 -0.308 None N 0.293 0.097 0.104622674875 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
N/S 14400 Ig-94 82 rs772475209 0.0847 -0.308 None N 0.293 0.097 0.104622674875 gnomAD-4.0.0 1.59372E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43707E-05 0
H/N 14756 Ig-98 82 None 0.1193 None 0.828 N 0.51 0.214 0.171388866994 gnomAD-4.0.0 1.59299E-06 None None None None N None 0 0 None 0 2.77948E-05 None 0 0 0 0 0
H/Y 14756 Ig-98 82 rs766470098 0.098 0.629 0.936 N 0.569 0.216 0.193865811164 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/Y 14756 Ig-98 82 rs766470098 0.098 0.629 0.936 N 0.569 0.216 0.193865811164 gnomAD-4.0.0 1.59299E-06 None None None None N None 0 2.28822E-05 None 0 0 None 0 0 0 0 0
K/R 15112 Ig-102 82 None 0.0843 None 0.959 N 0.447 0.11 0.325533332567 gnomAD-4.0.0 1.59441E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86338E-06 0 0
E/K 15383 Ig-105 82 rs773073914 0.3041 None 0.865 N 0.524 0.186 None gnomAD-4.0.0 6.854E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0052E-07 0 0
E/Q 15383 Ig-105 82 rs773073914 0.2458 -0.909 0.284 N 0.235 0.128 0.159798565429 gnomAD-2.1.1 1.08E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.58E-05 1.41563E-04
E/Q 15383 Ig-105 82 rs773073914 0.2458 -0.909 0.284 N 0.235 0.128 0.159798565429 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.57E-05 0 0 0 None 0 0 4.42E-05 0 0
E/Q 15383 Ig-105 82 rs773073914 0.2458 -0.909 0.284 N 0.235 0.128 0.159798565429 gnomAD-4.0.0 3.35225E-05 None None None None N None 0 1.67398E-05 None 0 0 None 0 0 4.24311E-05 0 4.81217E-05
K/N 15561 Ig-107 82 None 0.7286 None 1.0 N 0.702 0.244 0.258283824007 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 16345 Ig-110 84 None 0.5217 None 0.978 N 0.534 0.408 0.415690173769 gnomAD-4.0.0 1.61337E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.46839E-05 0
N/D 17041 Ig-111 87 rs751639212 0.21 -0.263 0.834 N 0.551 0.374 0.331619326243 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
N/D 17041 Ig-111 87 rs751639212 0.21 -0.263 0.834 N 0.551 0.374 0.331619326243 gnomAD-4.0.0 5.4792E-06 None None None None N None 0 0 None 0 0 None 0 0 7.20056E-06 0 0
N/S 17041 Ig-111 87 rs774659339 0.0908 None 0.716 N 0.499 0.178 0.240491677333 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/S 17041 Ig-111 87 rs774659339 0.0908 None 0.716 N 0.499 0.178 0.240491677333 gnomAD-4.0.0 1.11656E-05 None None None None N None 1.33697E-05 0 None 0 0 None 0 0 1.44193E-05 0 0
N/Y 17041 Ig-111 87 rs751639212 0.2065 None 0.991 N 0.804 0.605 0.623733534801 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94477E-04 None 0 0 0 0 0
N/Y 17041 Ig-111 87 rs751639212 0.2065 None 0.991 N 0.804 0.605 0.623733534801 gnomAD-4.0.0 6.57947E-06 None None None None N None 0 0 None 0 1.94477E-04 None 0 0 0 0 0
T/I 17363 Ig-112 113 None 0.1064 None 0.004 N 0.416 0.145 0.367425347029 gnomAD-4.0.0 7.3252E-07 None None None None N None 0 0 None 0 0 None 0 0 9.35203E-07 0 0
R/M 17758 Ig-113 82 None 0.4432 None 1.0 N 0.709 0.416 0.6236463853 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/S 17758 Ig-113 82 rs755982578 0.7382 -0.439 0.978 N 0.659 0.376 0.403609169532 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.6E-05 None 0 None 0 0 0
H/Q 18059 Ig-114 92 rs772133203 0.1639 -0.307 0.151 N 0.218 0.137 0.0551355673512 gnomAD-2.1.1 4.21E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
H/R 18059 Ig-114 92 None 0.1204 None 0.642 N 0.407 0.192 0.239901079897 gnomAD-4.0.0 1.38367E-06 None None None None N None 0 0 None 0 0 None 1.89725E-05 0 9.06965E-07 0 0
H/Y 18059 Ig-114 92 rs1329692225 0.1162 0.85 0.473 N 0.413 0.203 0.317958651998 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
R/G 18473 Ig-115 92 rs72646822 0.539 -0.848 1.0 N 0.707 0.5 None gnomAD-2.1.1 1.65709E-04 None None None None I None 1.71519E-03 6.22E-05 None 0 0 None 0 None 0 8.09E-06 0
R/G 18473 Ig-115 92 rs72646822 0.539 -0.848 1.0 N 0.707 0.5 None gnomAD-3.1.2 4.2087E-04 None None None None I None 1.49556E-03 6.56E-05 0 0 0 None 0 0 0 0 4.78469E-04
R/G 18473 Ig-115 92 rs72646822 0.539 -0.848 1.0 N 0.707 0.5 None 1000 genomes 5.99042E-04 None None None None I None 2.3E-03 0 None None 0 0 None None None 0 None
R/G 18473 Ig-115 92 rs72646822 0.539 -0.848 1.0 N 0.707 0.5 None gnomAD-4.0.0 8.6278E-05 None None None None I None 1.70298E-03 1.05787E-04 None 0 0 None 0 0 8.50589E-07 0 8.09297E-05
R/S 18473 Ig-115 92 None 0.6447 None 1.0 N 0.735 0.508 0.394685799254 gnomAD-4.0.0 1.62881E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8928E-06 0 0
R/T 18473 Ig-115 92 rs2053488389 0.3139 None 1.0 N 0.725 0.499 0.465721554213 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/T 18473 Ig-115 92 rs2053488389 0.3139 None 1.0 N 0.725 0.499 0.465721554213 gnomAD-4.0.0 6.57825E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47128E-05 0 0
R/I 18778 Ig-116 91 rs1178812946 0.4134 None 0.998 N 0.679 0.418 0.696300106271 gnomAD-4.0.0 1.4046E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.53145E-05 0
R/K 18778 Ig-116 91 None 0.1975 None 0.122 N 0.182 0.111 0.19670166235 gnomAD-4.0.0 7.02302E-07 None None None None N None 0 0 None 0 0 None 0 0 9.15127E-07 0 0
I/L 19177 Ig-117 83 rs1338580543 0.1554 -0.583 0.993 N 0.289 0.262 0.693807273274 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 5.71E-05 None 0 None 0 0 0
I/L 19177 Ig-117 83 rs1338580543 0.1554 -0.583 0.993 N 0.289 0.262 0.693807273274 gnomAD-4.0.0 1.5959E-06 None None None None N None 0 0 None 0 2.79501E-05 None 0 0 0 0 0
I/T 19177 Ig-117 83 None 0.1925 None 1.0 N 0.685 0.343 0.767533944701 gnomAD-4.0.0 1.59609E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86393E-06 0 0
I/V 19177 Ig-117 83 rs1338580543 0.0996 -0.866 0.993 N 0.285 0.198 0.668925388245 gnomAD-2.1.1 7.21E-06 None None None None N None 0 2.86E-05 None 0 0 None 0 None 0 7.89E-06 0
I/V 19177 Ig-117 83 rs1338580543 0.0996 -0.866 0.993 N 0.285 0.198 0.668925388245 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
I/V 19177 Ig-117 83 rs1338580543 0.0996 -0.866 0.993 N 0.285 0.198 0.668925388245 gnomAD-4.0.0 6.57505E-06 None None None None N None 0 6.55652E-05 None 0 0 None 0 0 0 0 0
Q/H 19473 Ig-118 83 rs186563991 0.1399 -0.839 0.927 N 0.531 0.317 0.402471007487 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
Q/H 19473 Ig-118 83 rs186563991 0.1399 -0.839 0.927 N 0.531 0.317 0.402471007487 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/H 19473 Ig-118 83 rs186563991 0.1399 -0.839 0.927 N 0.531 0.317 0.402471007487 gnomAD-4.0.0 6.57479E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47063E-05 0 0
K/E 19871 Ig-119 82 rs1475978640 0.4565 0.106 0.959 N 0.476 0.299 0.367229591828 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
K/E 19871 Ig-119 82 rs1475978640 0.4565 0.106 0.959 N 0.476 0.299 0.367229591828 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 19871 Ig-119 82 rs1475978640 0.4565 0.106 0.959 N 0.476 0.299 0.367229591828 gnomAD-4.0.0 3.72028E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08692E-06 0 0
K/T 19871 Ig-119 82 rs756249207 0.3564 -0.673 0.061 N 0.235 0.243 0.300110245524 gnomAD-2.1.1 8.08E-06 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 0 0
K/T 19871 Ig-119 82 rs756249207 0.3564 -0.673 0.061 N 0.235 0.243 0.300110245524 gnomAD-4.0.0 3.18692E-06 None None None None N None 0 4.58505E-05 None 0 0 None 0 0 0 0 0
H/L 20165 Ig-120 86 rs771554801 0.1998 0.569 0.959 N 0.59 0.322 0.685150128463 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.96E-05 0 None 0 None 0 0 0
H/L 20165 Ig-120 86 rs771554801 0.1998 0.569 0.959 N 0.59 0.322 0.685150128463 gnomAD-4.0.0 6.84352E-07 None None None None N None 0 0 None 3.82936E-05 0 None 0 0 0 0 0
H/Q 20165 Ig-120 86 None 0.2337 None 0.959 N 0.609 0.256 0.454798141022 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 5.04337E-05 None 0 0 0 0 0
H/R 20165 Ig-120 86 rs771554801 0.1076 -0.443 0.959 N 0.575 0.243 0.432041664125 gnomAD-2.1.1 1.07E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 1.56E-05 0
H/R 20165 Ig-120 86 rs771554801 0.1076 -0.443 0.959 N 0.575 0.243 0.432041664125 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/R 20165 Ig-120 86 rs771554801 0.1076 -0.443 0.959 N 0.575 0.243 0.432041664125 gnomAD-4.0.0 6.19849E-06 None None None None N None 1.3354E-05 0 None 0 0 None 0 0 6.78211E-06 0 1.60154E-05
I/M 20563 Ig-121 85 None 0.1056 None 0.916 N 0.558 0.201 0.592827455569 gnomAD-4.0.0 6.8451E-07 None None None None I None 0 0 None 0 2.52755E-05 None 0 0 0 0 0
I/V 20563 Ig-121 85 rs1278288633 0.0675 -0.836 0.002 N 0.128 0.095 0.461058313273 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
I/V 20563 Ig-121 85 rs1278288633 0.0675 -0.836 0.002 N 0.128 0.095 0.461058313273 gnomAD-4.0.0 1.59279E-06 None None None None I None 0 0 None 0 2.78195E-05 None 0 0 0 0 0
T/A 20858 Ig-122 90 rs200689750 0.0881 -0.79 0.454 N 0.477 0.218 None gnomAD-2.1.1 3.82624E-04 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 0 None 1.20385E-04 7.58951E-04 5.6243E-04
T/A 20858 Ig-122 90 rs200689750 0.0881 -0.79 0.454 N 0.477 0.218 None gnomAD-3.1.2 2.76145E-04 None None None None N None 2.41E-05 1.3101E-04 0 0 0 None 0 0 5.73681E-04 0 0
T/A 20858 Ig-122 90 rs200689750 0.0881 -0.79 0.454 N 0.477 0.218 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
T/A 20858 Ig-122 90 rs200689750 0.0881 -0.79 0.454 N 0.477 0.218 None gnomAD-4.0.0 5.65294E-04 None None None None N None 5.33049E-05 8.33556E-05 None 0 0 None 1.87911E-04 0 7.39219E-04 0 3.04204E-04
K/R 21950 Ig-125 85 None 0.0931 None 0.235 N 0.302 0.111 0.324161360171 gnomAD-4.0.0 1.81447E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.86588E-05 0
V/A 22348 Ig-126 84 None 0.2708 None 0.822 N 0.493 0.313 0.734690525238 gnomAD-4.0.0 2.05386E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69939E-06 0 0
V/I 22348 Ig-126 84 rs776484491 0.0862 -0.17 0.058 N 0.309 0.064 0.557090038421 gnomAD-2.1.1 7.16E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.57E-05 0
V/I 22348 Ig-126 84 rs776484491 0.0862 -0.17 0.058 N 0.309 0.064 0.557090038421 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 22348 Ig-126 84 rs776484491 0.0862 -0.17 0.058 N 0.309 0.064 0.557090038421 gnomAD-4.0.0 3.84758E-06 None None None None I None 0 0 None 0 0 None 0 0 7.18539E-06 0 0
S/C 22637 Ig-127 78 rs1233992072 0.0955 -0.117 0.612 N 0.46 0.355 0.547039986869 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/C 22637 Ig-127 78 rs1233992072 0.0955 -0.117 0.612 N 0.46 0.355 0.547039986869 gnomAD-4.0.0 1.59214E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85977E-06 0 0
K/Q 23034 Ig-128 85 rs1347501041 0.1363 None 0.782 N 0.666 0.184 0.190952846119 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/Q 23034 Ig-128 85 rs1347501041 0.1363 None 0.782 N 0.666 0.184 0.190952846119 gnomAD-4.0.0 6.58337E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47158E-05 0 0
N/I 23429 Ig-129 85 None 0.3255 None 0.994 D 0.826 0.388 0.772142110047 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/Y 23429 Ig-129 85 None 0.3715 None 0.998 D 0.821 0.448 0.758381520966 gnomAD-4.0.0 2.73717E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59831E-06 0 0
T/I 23720 Ig-130 84 None 0.1446 None 0.997 D 0.776 0.468 0.61789491966 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/S 23720 Ig-130 84 rs1709538154 0.1101 None 0.362 N 0.363 0.14 0.340032825777 gnomAD-4.0.0 1.59251E-06 None None None None N None 5.65803E-05 0 None 0 0 None 0 0 0 0 0
N/S 24116 Ig-131 88 rs767147291 0.0745 -0.747 0.581 N 0.509 0.216 0.233150807113 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
N/S 24116 Ig-131 88 rs767147291 0.0745 -0.747 0.581 N 0.509 0.216 0.233150807113 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 24513 Ig-132 83 rs1195528043 0.0858 -0.685 0.034 N 0.157 0.068 0.188950314367 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.67823E-04 None 0 None 0 0 0
N/S 24513 Ig-132 83 rs1195528043 0.0858 -0.685 0.034 N 0.157 0.068 0.188950314367 gnomAD-4.0.0 4.10614E-06 None None None None I None 0 0 None 0 1.51416E-04 None 0 0 0 0 0
N/H 24802 Ig-133 87 None 0.0744 None 0.896 N 0.56 0.238 0.280987212366 gnomAD-4.0.0 1.5919E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85951E-06 0 0
N/Y 24802 Ig-133 87 rs1178547441 0.1619 -0.159 0.963 D 0.629 0.352 0.536942225882 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/Y 24802 Ig-133 87 rs1178547441 0.1619 -0.159 0.963 D 0.629 0.352 0.536942225882 gnomAD-4.0.0 1.5919E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
E/D 25884 Ig-136 87 rs748940985 0.0994 -0.879 0.014 D 0.301 0.133 0.327686398923 gnomAD-2.1.1 1.79E-05 None None None None N None 0 1.41603E-04 None 0 0 None 0 None 0 0 0
E/D 25884 Ig-136 87 rs748940985 0.0994 -0.879 0.014 D 0.301 0.133 0.327686398923 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
E/D 25884 Ig-136 87 rs748940985 0.0994 -0.879 0.014 D 0.301 0.133 0.327686398923 gnomAD-4.0.0 3.09925E-06 None None None None N None 0 8.34084E-05 None 0 0 None 0 0 0 0 0
E/K 25884 Ig-136 87 rs747699837 0.1418 -0.029 0.963 N 0.578 0.303 0.328222422547 gnomAD-2.1.1 2.15E-05 None None None None N None 0 2.83E-05 None 9.68E-05 0 None 3.27E-05 None 0 2.35E-05 0
E/K 25884 Ig-136 87 rs747699837 0.1418 -0.029 0.963 N 0.578 0.303 0.328222422547 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 2.07125E-04 0
E/K 25884 Ig-136 87 rs747699837 0.1418 -0.029 0.963 N 0.578 0.303 0.328222422547 gnomAD-4.0.0 2.10757E-05 None None None None N None 0 1.66828E-05 None 3.37952E-05 0 None 0 0 2.20418E-05 4.39203E-05 3.20359E-05
N/H 26280 Ig-137 88 None 0.0975 None 0.979 D 0.501 0.391 0.35139820857 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/T 26280 Ig-137 88 rs569174612 0.0868 -0.222 0.003 N 0.106 0.109 0.209622950755 gnomAD-2.1.1 4.13E-06 None None None None I None 6.54E-05 0 None 0 0 None 0 None 0 0 0
N/T 26280 Ig-137 88 rs569174612 0.0868 -0.222 0.003 N 0.106 0.109 0.209622950755 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/T 26280 Ig-137 88 rs569174612 0.0868 -0.222 0.003 N 0.106 0.109 0.209622950755 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
N/T 26280 Ig-137 88 rs569174612 0.0868 -0.222 0.003 N 0.106 0.109 0.209622950755 gnomAD-4.0.0 2.5842E-06 None None None None I None 3.40472E-05 0 None 0 0 None 0 0 0 0 0
T/S 26677 Ig-138 84 rs2154165331 0.1193 None 0.034 N 0.159 0.118 0.233785782151 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 26966 Ig-139 87 rs1705281282 0.5562 None 0.491 N 0.494 0.272 0.260249123532 gnomAD-4.0.0 3.85873E-05 None None None None N None 6.36699E-05 0 None 0 0 None 0 0 4.08754E-05 0 0
T/I 27363 Ig-140 86 None 0.1012 None 0.007 N 0.3 0.222 0.272639205421 gnomAD-4.0.0 1.59134E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
N/I 27760 Ig-141 85 rs200714263 0.3347 0.421 1.0 D 0.835 0.446 0.740940019567 gnomAD-2.1.1 2.88E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.3E-05 0
N/I 27760 Ig-141 85 rs200714263 0.3347 0.421 1.0 D 0.835 0.446 0.740940019567 gnomAD-3.1.2 5.92E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 8.82E-05 2.06782E-04 0
N/I 27760 Ig-141 85 rs200714263 0.3347 0.421 1.0 D 0.835 0.446 0.740940019567 gnomAD-4.0.0 3.34766E-05 None None None None I None 2.66567E-05 0 None 0 0 None 0 1.65017E-04 4.15431E-05 2.19679E-05 0
T/A 28049 Ig-142 87 None 0.0842 None 0.002 N 0.131 0.07 0.335414705075 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85964E-06 0 0
T/I 28049 Ig-142 87 rs762467183 0.1855 0.374 0.81 N 0.481 0.246 0.623996689363 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
T/S 28049 Ig-142 87 None 0.09 None 0.002 N 0.132 0.048 0.341226946553 gnomAD-4.0.0 3.18465E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71942E-06 0 0
N/D 28444 Ig-143 87 None 0.2532 None 0.958 N 0.61 0.382 0.362758974969 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 28839 Ig-144 85 rs1186404293 0.0746 -0.205 None N 0.179 0.09 0.523342287332 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65948E-04
V/I 28839 Ig-144 85 rs1186404293 0.0746 -0.205 None N 0.179 0.09 0.523342287332 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 28839 Ig-144 85 rs1186404293 0.0746 -0.205 None N 0.179 0.09 0.523342287332 gnomAD-4.0.0 1.85911E-06 None None None None N None 0 1.66722E-05 None 0 0 None 0 0 8.47624E-07 0 1.60123E-05
R/G 29527 Ig-146 84 rs779247881 0.2187 -0.812 0.722 N 0.672 0.326 0.677622474905 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 29527 Ig-146 84 rs779247881 0.2187 -0.812 0.722 N 0.672 0.326 0.677622474905 gnomAD-4.0.0 6.84186E-06 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 1.79886E-06 6.95604E-05 1.65656E-05
R/T 29527 Ig-146 84 rs1450823990 0.1399 -0.322 0.722 N 0.685 0.302 0.548188646194 gnomAD-2.1.1 6.37E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.29668E-04 0
R/T 29527 Ig-146 84 rs1450823990 0.1399 -0.322 0.722 N 0.685 0.302 0.548188646194 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/T 29527 Ig-146 84 rs1450823990 0.1399 -0.322 0.722 N 0.685 0.302 0.548188646194 gnomAD-4.0.0 5.12392E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57089E-06 0 0
S/N 29927 Ig-147 86 rs1462504715 0.0957 -0.535 None N 0.183 0.091 0.0611884634855 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
S/N 29927 Ig-147 86 rs1462504715 0.0957 -0.535 None N 0.183 0.091 0.0611884634855 gnomAD-4.0.0 3.42566E-06 None None None None N None 0 0 None 0 2.52232E-05 None 0 0 2.702E-06 1.16055E-05 0
T/A 30218 Ig-148 87 rs768528782 0.1057 -0.619 0.826 N 0.505 0.118 0.289098819767 gnomAD-2.1.1 2.51E-05 None None None None N None 0 0 None 0 3.58901E-04 None 0 None 0 0 0
T/A 30218 Ig-148 87 rs768528782 0.1057 -0.619 0.826 N 0.505 0.118 0.289098819767 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.85208E-04 None 0 0 0 0 0
T/A 30218 Ig-148 87 rs768528782 0.1057 -0.619 0.826 N 0.505 0.118 0.289098819767 gnomAD-4.0.0 6.40741E-06 None None None None N None 0 0 None 0 9.6965E-05 None 0 0 0 0 2.84544E-05
T/I 30218 Ig-148 87 rs2154151142 0.1637 None 0.996 N 0.517 0.316 0.399740851666 gnomAD-4.0.0 6.84353E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65717E-05
K/E 30613 Ig-149 82 None 0.0915 None 0.006 N 0.227 0.093 0.21737058555 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/I 31702 Ig-152 82 None 0.1056 None None N 0.083 0.126 0.418718287753 gnomAD-4.0.0 2.05814E-06 None None None None N None 0 0 None 0 0 None 0 0 2.705E-06 0 0
M/L 31702 Ig-152 82 rs370696758 0.0759 -0.234 None N 0.081 0.14 0.36893422563 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
M/L 31702 Ig-152 82 rs370696758 0.0759 -0.234 None N 0.081 0.14 0.36893422563 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/L 31702 Ig-152 82 rs370696758 0.0759 -0.234 None N 0.081 0.14 0.36893422563 gnomAD-4.0.0 1.86259E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54752E-06 0 0
M/T 31702 Ig-152 82 rs778808720 0.0701 -0.512 None N 0.157 0.118 0.538974603628 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
M/T 31702 Ig-152 82 rs778808720 0.0701 -0.512 None N 0.157 0.118 0.538974603628 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 31702 Ig-152 82 rs778808720 0.0701 -0.512 None N 0.157 0.118 0.538974603628 gnomAD-4.0.0 3.10482E-06 None None None None N None 0 0 None 0 0 None 0 0 4.24663E-06 0 0
M/V 31702 Ig-152 82 rs370696758 0.0621 -0.521 None N 0.097 0.112 0.469742815239 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.31E-05 None 0 0 0
M/V 31702 Ig-152 82 rs370696758 0.0621 -0.521 None N 0.097 0.112 0.469742815239 gnomAD-4.0.0 4.11398E-06 None None None None N None 0 0 None 0 0 None 0 0 4.50618E-06 1.16404E-05 0
K/E 32393 Ig-154 87 rs374081110 0.2547 0.013 0.201 N 0.555 0.232 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.56E-05 None 0 None 0 0 0
K/E 32393 Ig-154 87 rs374081110 0.2547 0.013 0.201 N 0.555 0.232 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/E 32393 Ig-154 87 rs374081110 0.2547 0.013 0.201 N 0.555 0.232 None gnomAD-4.0.0 2.47967E-06 None None None None I None 1.33494E-05 0 None 0 2.22866E-05 None 0 0 1.69597E-06 0 0
K/R 32393 Ig-154 87 None 0.0869 None 0.002 D 0.359 0.141 0.315609569513 gnomAD-4.0.0 1.59291E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86274E-06 0 0
K/Q 32789 Ig-155 82 rs769760458 0.1717 0.101 1.0 N 0.717 0.374 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/Q 32789 Ig-155 82 rs769760458 0.1717 0.101 1.0 N 0.717 0.374 None gnomAD-4.0.0 3.18251E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71598E-06 0 0
K/R 32789 Ig-155 82 rs748701203 0.1003 -0.092 0.999 N 0.554 0.395 None gnomAD-2.1.1 1.28736E-04 None None None None N None 0 0 None 0 0 None 0 None 1.2026E-03 3.13E-05 2.80978E-04
K/R 32789 Ig-155 82 rs748701203 0.1003 -0.092 0.999 N 0.554 0.395 None gnomAD-3.1.2 9.2E-05 None None None None N None 0 0 0 0 0 None 1.22411E-03 0 0 0 4.78011E-04
K/R 32789 Ig-155 82 rs748701203 0.1003 -0.092 0.999 N 0.554 0.395 None gnomAD-4.0.0 5.14363E-05 None None None None N None 0 0 None 0 0 None 1.12613E-03 0 3.39042E-06 0 1.12068E-04
K/R 33187 Ig-156 87 rs560306385 0.0902 -0.526 0.951 N 0.287 0.152 0.344017737713 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.95E-05 0 None 0 None 0 0 0
K/R 33187 Ig-156 87 rs560306385 0.0902 -0.526 0.951 N 0.287 0.152 0.344017737713 gnomAD-4.0.0 6.84231E-07 None None None None N None 0 0 None 3.8276E-05 0 None 0 0 0 0 0
K/T 33187 Ig-156 87 rs560306385 0.2787 -1.062 1.0 N 0.743 0.421 0.364141725642 gnomAD-2.1.1 4.28E-05 None None None None N None 4.14E-05 1.41555E-04 None 0 0 None 0 None 0 3.12E-05 2.81057E-04
K/T 33187 Ig-156 87 rs560306385 0.2787 -1.062 1.0 N 0.743 0.421 0.364141725642 gnomAD-3.1.2 1.97187E-04 None None None None N None 9.65E-05 1.5713E-03 0 0 0 None 0 0 1.47E-05 0 4.79846E-04
K/T 33187 Ig-156 87 rs560306385 0.2787 -1.062 1.0 N 0.743 0.421 0.364141725642 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
K/T 33187 Ig-156 87 rs560306385 0.2787 -1.062 1.0 N 0.743 0.421 0.364141725642 gnomAD-4.0.0 3.40821E-05 None None None None N None 5.33191E-05 6.49957E-04 None 0 0 None 0 0 5.93345E-06 0 8.0041E-05
D/E 33284 Ig-157 82 None 0.194 None 0.029 N 0.433 0.107 0.236278675362 gnomAD-4.0.0 7.10619E-07 None None None None N None 0 0 None 0 0 None 0 0 9.2031E-07 0 0
D/H 33284 Ig-157 82 None 0.2211 None 0.749 N 0.601 0.169 0.271763555656 gnomAD-4.0.0 7.10201E-07 None None None None N None 0 0 None 0 0 None 0 0 9.20458E-07 0 0
S/A 33584 Ig-158 89 rs1280611526 0.1054 None 0.765 N 0.531 0.255 0.294918367191 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/A 33584 Ig-158 89 rs1280611526 0.1054 None 0.765 N 0.531 0.255 0.294918367191 gnomAD-4.0.0 6.57134E-06 None None None None N None 2.41255E-05 0 None 0 0 None 0 0 0 0 0
S/P 33584 Ig-158 89 rs1280611526 0.5932 -0.464 0.999 N 0.751 0.513 0.440394187108 gnomAD-2.1.1 5.38E-06 None None None None N None 0 0 None 0 6.39E-05 None 0 None 0 0 0
S/P 33584 Ig-158 89 rs1280611526 0.5932 -0.464 0.999 N 0.751 0.513 0.440394187108 gnomAD-4.0.0 1.82323E-06 None None None None N None 0 0 None 0 2.82008E-05 None 0 0 0 0 0
E/K 33683 Ig-159 88 rs747577276 0.7617 -1.047 0.999 N 0.655 0.475 0.499218193508 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.30719E-04 None 0 0 0
E/K 33683 Ig-159 88 rs747577276 0.7617 -1.047 0.999 N 0.655 0.475 0.499218193508 gnomAD-4.0.0 4.78944E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11538E-05 0
K/R 34347 Ig-161 90 rs1187906800 0.0879 None 0.011 N 0.129 0.178 0.30212335484 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92234E-04 None 0 0 0 0 0
K/R 34347 Ig-161 90 rs1187906800 0.0879 None 0.011 N 0.129 0.178 0.30212335484 gnomAD-4.0.0 6.56901E-06 None None None None N None 0 0 None 0 1.92234E-04 None 0 0 0 0 0
T/M 35028 Ig-163 87 rs56001826 0.2794 -0.162 1.0 N 0.776 0.45 0.671314693576 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/M 35028 Ig-163 87 rs56001826 0.2794 -0.162 1.0 N 0.776 0.45 0.671314693576 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
T/M 35028 Ig-163 87 rs56001826 0.2794 -0.162 1.0 N 0.776 0.45 0.671314693576 gnomAD-4.0.0 5.57693E-06 None None None None N None 6.67485E-05 0 None 0 0 None 0 0 3.3902E-06 0 0
T/A 35215 Ig-164 87 None 0.1326 None 0.9 D 0.519 0.3 0.33085137897 gnomAD-4.0.0 6.84137E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99391E-07 0 0
T/I 35215 Ig-164 87 rs1340897756 0.1757 -0.28 0.997 N 0.817 0.347 0.559658259148 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
T/I 35215 Ig-164 87 rs1340897756 0.1757 -0.28 0.997 N 0.817 0.347 0.559658259148 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 35215 Ig-164 87 rs1340897756 0.1757 -0.28 0.997 N 0.817 0.347 0.559658259148 gnomAD-4.0.0 3.09811E-06 None None None None N None 1.33476E-05 0 None 0 2.22757E-05 None 0 0 2.54257E-06 0 0
T/P 35215 Ig-164 87 rs769195414 0.3227 -0.696 0.997 N 0.815 0.489 0.589254406313 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.55E-05 0
T/P 35215 Ig-164 87 rs769195414 0.3227 -0.696 0.997 N 0.815 0.489 0.589254406313 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/P 35215 Ig-164 87 rs769195414 0.3227 -0.696 0.997 N 0.815 0.489 0.589254406313 gnomAD-4.0.0 5.57683E-06 None None None None N None 0 1.66683E-05 None 0 0 None 0 0 6.78029E-06 0 0
Q/K 35373 Ig-165 88 rs778126842 0.0993 0.003 0.081 N 0.53 0.218 0.171388866994 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 8.87E-06 0
Q/K 35373 Ig-165 88 rs778126842 0.0993 0.003 0.081 N 0.53 0.218 0.171388866994 gnomAD-4.0.0 6.15732E-06 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 6.29577E-06 0 1.65634E-05
K/R 35506 Ig-166 87 None 0.1016 None 0.001 N 0.12 0.112 0.247872288689 gnomAD-4.0.0 6.93101E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02866E-07 0 0
K/T 35506 Ig-166 87 rs1688340193 0.2261 None 0.003 N 0.217 0.317 0.273503213844 gnomAD-4.0.0 6.23791E-06 None None None None N None 0 0 None 0 0 None 0 0 7.22293E-06 0 1.676E-05
S/A 35788 Ig-168 87 rs773306658 0.1149 -0.361 0.987 N 0.465 0.391 0.326616659874 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
S/A 35788 Ig-168 87 rs773306658 0.1149 -0.361 0.987 N 0.465 0.391 0.326616659874 gnomAD-4.0.0 1.5914E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85834E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.