Structural position:

  • Domain Type: Ig
  • Aligned Position: 23
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/D 19 Ig-1 14 rs781416228 0.5888 -1.446 0.979 N 0.446 0.361 0.560989807984 gnomAD-2.1.1 3.98E-06 None None None -0.766(TCAP) N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
E/D 19 Ig-1 14 rs781416228 0.5888 -1.446 0.979 N 0.446 0.361 0.560989807984 gnomAD-4.0.0 2.05234E-06 None None None -0.766(TCAP) N None 0 0 None 0 0 None 0 0 2.69797E-06 0 0
E/G 19 Ig-1 14 rs954288080 0.6028 None 1.0 D 0.639 0.522 0.621312436561 gnomAD-2.1.1 3.98E-06 None None None -0.793(TCAP) N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
E/G 19 Ig-1 14 rs954288080 0.6028 None 1.0 D 0.639 0.522 0.621312436561 gnomAD-4.0.0 1.59072E-06 None None None -0.793(TCAP) N None 0 0 None 0 0 None 0 0 0 0 3.02243E-05
Q/L 117 Ig-2 14 rs2094009394 0.5073 None 0.001 N 0.303 0.271 0.417843521124 gnomAD-4.0.0 1.59457E-06 None None None -0.279(TCAP) N None 0 0 None 0 2.77423E-05 None 0 0 0 0 0
E/V 956 Ig-3 14 rs1256742632 0.9479 -0.148 1.0 N 0.689 0.565 0.710140478693 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
E/V 956 Ig-3 14 rs1256742632 0.9479 -0.148 1.0 N 0.689 0.565 0.710140478693 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/D 1095 Ig-4 14 rs372103803 0.4892 None 0.999 N 0.444 0.221 0.266843984389 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 1095 Ig-4 14 rs372103803 0.4892 None 0.999 N 0.444 0.221 0.266843984389 gnomAD-4.0.0 7.43491E-06 None None None None I None 0 0 None 0 0 None 0 0 8.47456E-06 0 3.20082E-05
R/C 1716 Ig-8 14 rs779424493 0.3657 -0.998 0.019 N 0.489 0.316 0.477994580393 gnomAD-2.1.1 1.6E-05 None None None None I None 1.23077E-04 0 None 0 5.45E-05 None 0 None 0 8.84E-06 0
R/C 1716 Ig-8 14 rs779424493 0.3657 -0.998 0.019 N 0.489 0.316 0.477994580393 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/C 1716 Ig-8 14 rs779424493 0.3657 -0.998 0.019 N 0.489 0.316 0.477994580393 gnomAD-4.0.0 6.81556E-06 None None None None I None 2.66994E-05 1.66706E-05 None 0 0 None 0 0 5.08464E-06 0 3.20123E-05
R/H 1716 Ig-8 14 rs771659260 0.1681 -1.523 0.95 N 0.312 0.29 0.324161360171 gnomAD-2.1.1 4.39E-05 None None None None I None 0 1.44802E-04 None 0 5.45E-05 None 0 None 0 4.42E-05 0
R/H 1716 Ig-8 14 rs771659260 0.1681 -1.523 0.95 N 0.312 0.29 0.324161360171 gnomAD-3.1.2 3.29E-05 None None None None I None 0 1.30907E-04 0 0 0 None 0 0 1.47E-05 2.07125E-04 4.78469E-04
R/H 1716 Ig-8 14 rs771659260 0.1681 -1.523 0.95 N 0.312 0.29 0.324161360171 gnomAD-4.0.0 2.47839E-05 None None None None I None 0 1.16698E-04 None 0 6.68807E-05 None 1.56187E-05 1.6442E-04 1.94913E-05 1.09789E-05 6.40225E-05
R/P 1716 Ig-8 14 None 0.6605 None 0.896 N 0.44 0.349 0.471292358255 gnomAD-4.0.0 6.84107E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
E/D 1854 Ig-9 14 rs571222694 0.8177 -0.198 0.999 N 0.458 0.175 0.257786959452 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 1854 Ig-9 14 rs571222694 0.8177 -0.198 0.999 N 0.458 0.175 0.257786959452 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
E/D 1854 Ig-9 14 rs571222694 0.8177 -0.198 0.999 N 0.458 0.175 0.257786959452 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/D 1854 Ig-9 14 rs571222694 0.8177 -0.198 0.999 N 0.458 0.175 0.257786959452 gnomAD-4.0.0 6.5653E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07383E-04 0
E/K 1854 Ig-9 14 rs1443747233 0.9466 0.553 0.999 N 0.608 0.315 0.27479166964 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
E/K 1854 Ig-9 14 rs1443747233 0.9466 0.553 0.999 N 0.608 0.315 0.27479166964 gnomAD-4.0.0 1.5907E-06 None None None None N None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
Q/R 2091 Ig-10 14 rs879012357 0.1224 0.147 0.055 N 0.32 0.072 None gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/D 2546 Ig-15 14 None 0.8829 None 0.999 N 0.43 0.291 0.202949470691 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/A 2633 Ig-16 13 None 0.612 None 0.999 N 0.628 0.391 0.232513804876 gnomAD-4.0.0 1.59102E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85768E-06 0 0
E/G 2720 Ig-17 14 rs755264814 0.5887 -0.736 1.0 D 0.639 0.792 0.712347878007 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/G 2720 Ig-17 14 rs755264814 0.5887 -0.736 1.0 D 0.639 0.792 0.712347878007 gnomAD-4.0.0 4.78915E-06 None None None None I None 0 0 None 0 0 None 0 0 0 8.11538E-05 0
E/K 2808 Ig-18 14 rs2154342769 0.5057 None 0.351 N 0.203 0.283 0.207176502487 gnomAD-4.0.0 1.59048E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
E/G 2982 Ig-20 14 rs2090998936 0.9586 None 1.0 D 0.652 0.545 0.446111551642 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
E/D 3071 Ig-21 14 rs779657872 0.9739 -1.033 0.999 N 0.435 0.306 0.132336055621 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/D 3071 Ig-21 14 rs779657872 0.9739 -1.033 0.999 N 0.435 0.306 0.132336055621 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 3071 Ig-21 14 rs779657872 0.9739 -1.033 0.999 N 0.435 0.306 0.132336055621 gnomAD-4.0.0 6.57125E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
E/G 3071 Ig-21 14 rs755629588 0.9425 -1.462 1.0 D 0.675 0.471 0.306695030598 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 6.53E-05 None 0 0 0
E/G 3071 Ig-21 14 rs755629588 0.9425 -1.462 1.0 D 0.675 0.471 0.306695030598 gnomAD-4.0.0 1.23137E-05 None None None None N None 0 0 None 0 0 None 0 1.7337E-04 4.49648E-06 1.27524E-04 1.6559E-05
E/Q 3071 Ig-21 14 rs777427458 0.85 -1.035 1.0 N 0.627 0.298 0.178374595973 gnomAD-2.1.1 1.59E-05 None None None None N None 0 0 None 0 0 None 1.30659E-04 None 0 0 0
E/Q 3071 Ig-21 14 rs777427458 0.85 -1.035 1.0 N 0.627 0.298 0.178374595973 gnomAD-4.0.0 6.84095E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99294E-07 1.04338E-04 0
E/D 3160 Ig-22 14 None 0.58 None 0.999 N 0.437 0.23 0.0954503805726 gnomAD-4.0.0 6.84907E-07 None None None None N None 0 0 None 0 2.52321E-05 None 0 0 0 0 0
E/G 3160 Ig-22 14 rs1234344822 0.5169 None 1.0 N 0.667 0.449 0.241078983079 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 3160 Ig-22 14 rs1234344822 0.5169 None 1.0 N 0.667 0.449 0.241078983079 gnomAD-4.0.0 6.57376E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
S/F 3252 Ig-23 14 rs1436391849 0.6658 -0.815 0.988 D 0.454 0.424 0.692115123808 gnomAD-2.1.1 1.99E-05 None None None None N None 0 1.15727E-04 None 0 0 None 0 None 0 0 1.63666E-04
S/F 3252 Ig-23 14 rs1436391849 0.6658 -0.815 0.988 D 0.454 0.424 0.692115123808 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30941E-04 0 0 0 None 0 0 0 0 0
S/F 3252 Ig-23 14 rs1436391849 0.6658 -0.815 0.988 D 0.454 0.424 0.692115123808 gnomAD-4.0.0 1.28087E-05 None None None None N None 0 1.52527E-04 None 0 0 None 0 0 2.3919E-06 0 0
N/D 3478 Ig-25 14 rs771324532 0.1213 -0.024 None None None 0.078 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
N/D 3478 Ig-25 14 rs771324532 0.1213 -0.024 None None None 0.078 None gnomAD-4.0.0 1.59162E-06 None None None None I None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
N/K 3478 Ig-25 14 None 0.2485 None None None None 0.102 None gnomAD-4.0.0 1.36854E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99544E-07 1.1598E-05 0
N/S 3478 Ig-25 14 None 0.0459 None None None None 0.117 None gnomAD-4.0.0 1.20034E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
C/Y 3673 Ig-26 14 None 0.1547 None None None None 0.061 None gnomAD-4.0.0 2.40066E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
M/I 3833 Ig-27 14 rs756868500 0.1054 0.029 None N 0.121 0.076 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 1.45113E-04 None 0 0 None 0 None 0 0 0
M/I 3833 Ig-27 14 rs756868500 0.1054 0.029 None N 0.121 0.076 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.31148E-04 0 0 0 None 0 0 0 0 0
M/I 3833 Ig-27 14 rs756868500 0.1054 0.029 None N 0.121 0.076 None gnomAD-4.0.0 1.02505E-05 None None None None N None 0 1.18725E-04 None 0 2.42648E-05 None 0 0 0 0 0
M/T 3833 Ig-27 14 rs2082519187 0.0999 None None N 0.137 0.139 None gnomAD-4.0.0 6.84255E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99501E-06 0 0
M/V 3833 Ig-27 14 None 0.0584 None None N 0.121 0.04 None gnomAD-4.0.0 1.59152E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
L/P 4713 Ig-30 14 None 0.6957 None 0.989 N 0.387 0.316 0.561446168695 gnomAD-4.0.0 1.59221E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85938E-06 0 0
V/M 4808 Ig-31 14 None 0.2241 None 0.999 N 0.495 0.248 0.367042808489 gnomAD-4.0.0 1.59814E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87054E-06 0 0
I/V 4901 Ig-32 14 rs886038840 0.0588 0.095 None N 0.117 0.059 0.15556083564 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 4901 Ig-32 14 rs886038840 0.0588 0.095 None N 0.117 0.059 0.15556083564 gnomAD-4.0.0 4.10536E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49726E-06 1.15934E-05 0
P/R 4995 Ig-33 15 rs72648927 0.2692 -0.217 0.669 N 0.381 0.189 None gnomAD-2.1.1 8.09052E-03 None None None None I None 1.4457E-03 2.09774E-03 None 1.07665E-02 0 None 5.13975E-03 None 2.47396E-02 9.38074E-03 8.53341E-03
P/R 4995 Ig-33 15 rs72648927 0.2692 -0.217 0.669 N 0.381 0.189 None gnomAD-3.1.2 7.18952E-03 None None None None I None 1.27927E-03 2.09561E-03 0 1.00865E-02 0 None 2.64545E-02 0 9.64309E-03 4.1425E-03 8.12619E-03
P/R 4995 Ig-33 15 rs72648927 0.2692 -0.217 0.669 N 0.381 0.189 None 1000 genomes 4.39297E-03 None None None None I None 8E-04 0 None None 0 1.89E-02 None None None 2E-03 None
P/R 4995 Ig-33 15 rs72648927 0.2692 -0.217 0.669 N 0.381 0.189 None gnomAD-4.0.0 8.84273E-03 None None None None I None 1.29406E-03 2.28891E-03 None 1.09845E-02 0 None 2.53194E-02 2.31482E-03 9.40517E-03 4.92611E-03 8.42724E-03
P/S 4995 Ig-33 15 rs776578141 0.2817 -0.91 0.801 N 0.293 0.203 0.132336055621 gnomAD-2.1.1 1.27E-05 None None None None I None 6.77E-05 0 None 0 0 None 0 None 0 9.5E-06 1.72295E-04
P/S 4995 Ig-33 15 rs776578141 0.2817 -0.91 0.801 N 0.293 0.203 0.132336055621 gnomAD-3.1.2 6.57E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
P/S 4995 Ig-33 15 rs776578141 0.2817 -0.91 0.801 N 0.293 0.203 0.132336055621 gnomAD-4.0.0 2.23889E-05 None None None None I None 1.33683E-05 0 None 0 0 None 0 0 2.8894E-05 0 1.6057E-05
R/K 5088 Ig-34 14 rs766300782 0.1417 -0.104 0.002 N 0.169 0.117 0.230578612272 gnomAD-2.1.1 4.25E-06 None None None None I None 0 0 None 0 0 None 3.73E-05 None 0 0 0
R/K 5088 Ig-34 14 rs766300782 0.1417 -0.104 0.002 N 0.169 0.117 0.230578612272 gnomAD-4.0.0 3.27612E-06 None None None None I None 0 0 None 0 0 None 0 0 0 3.00716E-05 0
G/A 5181 Ig-35 14 rs201185434 0.0441 -0.218 None N 0.081 0.133 None gnomAD-2.1.1 4.09427E-04 None None None None I None 4.42515E-03 1.99624E-04 None 0 0 None 0 None 0 0 0
G/A 5181 Ig-35 14 rs201185434 0.0441 -0.218 None N 0.081 0.133 None gnomAD-3.1.2 1.00565E-03 None None None None I None 3.54781E-03 3.27482E-04 0 0 0 None 0 0 0 0 4.79386E-04
G/A 5181 Ig-35 14 rs201185434 0.0441 -0.218 None N 0.081 0.133 None 1000 genomes 1.39776E-03 None None None None I None 3.8E-03 2.9E-03 None None 0 0 None None None 0 None
G/A 5181 Ig-35 14 rs201185434 0.0441 -0.218 None N 0.081 0.133 None gnomAD-4.0.0 1.70952E-04 None None None None I None 3.25785E-03 2.01025E-04 None 0 0 None 0 0 4.25171E-06 0 2.24965E-04
G/R 5181 Ig-35 14 rs1477393359 0.1617 -0.489 0.001 N 0.351 0.168 0.313518423057 gnomAD-2.1.1 8.1E-06 None None None None I None 0 0 None 0 1.11807E-04 None 0 None 0 0 0
G/R 5181 Ig-35 14 rs1477393359 0.1617 -0.489 0.001 N 0.351 0.168 0.313518423057 gnomAD-4.0.0 6.86807E-07 None None None None I None 0 0 None 0 0 None 0 0 9.02739E-07 0 0
V/F 5370 Ig-37 14 rs1560821296 0.1446 None 0.003 N 0.211 0.172 0.457106177737 gnomAD-4.0.0 1.37176E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80253E-06 0 0
V/I 5370 Ig-37 14 None 0.0722 None 0.001 N 0.127 0.112 0.1749357433 gnomAD-4.0.0 2.05765E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80253E-06 1.16539E-05 0
V/L 5370 Ig-37 14 None 0.1272 None 0.001 N 0.097 0.112 0.128392430309 gnomAD-4.0.0 6.85882E-07 None None None None I None 0 0 None 0 2.52934E-05 None 0 0 0 0 0
P/S 5463 Ig-38 14 rs748705824 0.2409 -0.65 1.0 N 0.759 0.351 0.156986980423 gnomAD-2.1.1 4.14E-06 None None None None I None 0 0 None 0 0 None 3.45E-05 None 0 0 0
P/S 5463 Ig-38 14 rs748705824 0.2409 -0.65 1.0 N 0.759 0.351 0.156986980423 gnomAD-4.0.0 1.37516E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.17553E-05 1.66628E-05
P/T 5463 Ig-38 14 rs748705824 0.1742 -0.596 1.0 N 0.753 0.349 0.266843984389 gnomAD-2.1.1 8.28E-06 None None None None I None 0 0 None 0 0 None 6.89E-05 None 0 0 0
P/T 5463 Ig-38 14 rs748705824 0.1742 -0.596 1.0 N 0.753 0.349 0.266843984389 gnomAD-4.0.0 1.37516E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.35106E-05 0
K/R 5650 Ig-40 14 rs1429494735 0.0805 None 0.001 N 0.157 0.047 0.151104730317 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 5650 Ig-40 14 rs1429494735 0.0805 None 0.001 N 0.157 0.047 0.151104730317 gnomAD-4.0.0 5.13398E-06 None None None None I None 0 0 None 0 0 None 0 0 9.59767E-06 0 0
R/L 5743 Ig-41 14 rs753892271 0.1828 0.503 None N 0.082 0.14 0.195762928549 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
R/L 5743 Ig-41 14 rs753892271 0.1828 0.503 None N 0.082 0.14 0.195762928549 gnomAD-4.0.0 6.84746E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16069E-05 0
R/Q 5743 Ig-41 14 rs753892271 0.0922 0.075 0.004 N 0.221 0.055 0.0716867268079 gnomAD-2.1.1 3.23072E-04 None None None None I None 4.14E-05 2.35997E-03 None 0 5.17E-05 None 3.28E-05 None 4.02E-05 1.57E-05 1.41764E-04
R/Q 5743 Ig-41 14 rs753892271 0.0922 0.075 0.004 N 0.221 0.055 0.0716867268079 gnomAD-3.1.2 3.29E-05 None None None None I None 2.41E-05 1.96541E-04 0 0 0 None 0 0 1.47E-05 0 0
R/Q 5743 Ig-41 14 rs753892271 0.0922 0.075 0.004 N 0.221 0.055 0.0716867268079 gnomAD-4.0.0 7.31789E-05 None None None None I None 8.01582E-05 1.51976E-03 None 3.38662E-05 4.47067E-05 None 1.56416E-05 0 9.32833E-06 2.19829E-05 6.41087E-05
R/W 5743 Ig-41 14 rs377193479 0.1716 -0.315 0.99 N 0.225 0.173 None gnomAD-2.1.1 4.45E-05 None None None None I None 6.47E-05 0 None 0 0 None 9.84E-05 None 0 6.26E-05 0
R/W 5743 Ig-41 14 rs377193479 0.1716 -0.315 0.99 N 0.225 0.173 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/W 5743 Ig-41 14 rs377193479 0.1716 -0.315 0.99 N 0.225 0.173 None gnomAD-4.0.0 3.03865E-05 None None None None I None 1.33372E-05 1.66978E-05 None 0 0 None 0 0 3.39226E-05 6.59486E-05 1.602E-05
Q/L 5836 Ig-42 14 None 0.122 None 0.001 N 0.118 0.112 0.280987212366 gnomAD-4.0.0 1.59151E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02462E-05
Q/R 5836 Ig-42 14 rs760072345 0.0966 0.207 0.351 N 0.243 0.115 0.107399877778 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
Q/R 5836 Ig-42 14 rs760072345 0.0966 0.207 0.351 N 0.243 0.115 0.107399877778 gnomAD-4.0.0 3.18301E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71775E-06 0 0
K/T 5932 Ig-43 14 rs879062650 0.31 None 0.998 N 0.553 0.41 None gnomAD-4.0.0 1.59791E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87394E-06 0 0
N/S 6119 Ig-45 15 None 0.0809 None 0.042 N 0.278 0.136 0.214338557667 gnomAD-4.0.0 4.77681E-06 None None None None I None 0 2.29001E-05 None 0 0 None 1.88437E-05 0 2.8593E-06 0 0
L/F 6305 Ig-47 14 rs1197830521 0.1423 None 0.391 N 0.289 0.109 0.359963025489 gnomAD-4.0.0 6.87102E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.66362E-05
L/W 6305 Ig-47 14 rs1267771409 0.2101 -1.331 1.0 N 0.637 0.403 0.758618040938 gnomAD-2.1.1 4.18E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.27E-06 0
E/A 6398 Ig-48 14 rs756732703 0.1949 -0.552 0.051 N 0.133 0.121 0.203808441222 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
E/A 6398 Ig-48 14 rs756732703 0.1949 -0.552 0.051 N 0.133 0.121 0.203808441222 gnomAD-4.0.0 4.81468E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.30911E-05 0
L/R 6494 Ig-49 14 rs376857772 0.1803 -0.261 0.983 N 0.632 0.33 None gnomAD-2.1.1 9.52E-05 None None None None N None 1.67434E-04 0 None 0 1.14919E-03 None 0 None 0 0 0
L/R 6494 Ig-49 14 rs376857772 0.1803 -0.261 0.983 N 0.632 0.33 None gnomAD-3.1.2 5.91E-05 None None None None N None 7.24E-05 0 0 0 1.1592E-03 None 0 0 0 0 0
L/R 6494 Ig-49 14 rs376857772 0.1803 -0.261 0.983 N 0.632 0.33 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
L/R 6494 Ig-49 14 rs376857772 0.1803 -0.261 0.983 N 0.632 0.33 None gnomAD-4.0.0 2.67282E-05 None None None None N None 8.01946E-05 0 None 0 6.03865E-04 None 0 0 8.48764E-07 0 1.44662E-04
P/R 6587 Ig-50 14 rs2079621657 0.3117 None 0.999 N 0.75 0.383 0.330589388543 gnomAD-4.0.0 1.60498E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.46011E-05 0
P/T 6587 Ig-50 14 None 0.2025 None 0.999 N 0.709 0.332 0.263612267334 gnomAD-4.0.0 6.86684E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01634E-07 0 0
A/E 6681 Ig-51 15 None 0.1567 None 0.473 N 0.457 0.161 0.20549828249 gnomAD-4.0.0 6.85891E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00985E-07 0 0
A/T 6681 Ig-51 15 rs779405672 0.0915 -0.594 0.642 N 0.367 0.103 0.204665344411 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 1.68691E-04
A/T 6681 Ig-51 15 rs779405672 0.0915 -0.594 0.642 N 0.367 0.103 0.204665344411 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 6681 Ig-51 15 rs779405672 0.0915 -0.594 0.642 N 0.367 0.103 0.204665344411 gnomAD-4.0.0 6.83249E-06 None None None None N None 0 1.67768E-05 None 0 0 None 0 1.65017E-04 5.94309E-06 0 3.21161E-05
A/V 6681 Ig-51 15 rs2079510366 0.1024 None 0.27 N 0.358 0.088 0.17948927462 gnomAD-4.0.0 2.05767E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70295E-06 0 0
K/R 6774 Ig-52 14 rs776943120 0.0846 -0.019 0.001 N 0.235 0.114 0.322230723748 gnomAD-2.1.1 4.21E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.2E-06 0
K/R 6774 Ig-52 14 rs776943120 0.0846 -0.019 0.001 N 0.235 0.114 0.322230723748 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
K/R 6774 Ig-52 14 rs776943120 0.0846 -0.019 0.001 N 0.235 0.114 0.322230723748 gnomAD-4.0.0 3.13377E-06 None None None None I None 0 0 None 0 0 None 0 0 4.27495E-06 0 0
K/T 6774 Ig-52 14 None 0.3343 None 0.712 N 0.557 0.408 0.513560046879 gnomAD-4.0.0 6.92817E-07 None None None None I None 0 0 None 0 0 None 0 0 9.07782E-07 0 0
A/S 6867 Ig-53 14 rs761337704 0.0912 -0.679 0.003 N 0.139 0.132 0.124217242631 gnomAD-2.1.1 8.23E-06 None None None None N None 0 0 None 0 1.11832E-04 None 0 None 0 0 0
A/S 6867 Ig-53 14 rs761337704 0.0912 -0.679 0.003 N 0.139 0.132 0.124217242631 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
A/S 6867 Ig-53 14 rs761337704 0.0912 -0.679 0.003 N 0.139 0.132 0.124217242631 gnomAD-4.0.0 3.87215E-06 None None None None N None 0 0 None 0 7.28297E-05 None 0 0 0 0 0
A/V 6867 Ig-53 14 rs368458114 0.0764 None 0.001 N 0.129 0.122 None gnomAD-4.0.0 3.43327E-06 None None None None N None 0 0 None 0 2.52296E-05 None 0 0 3.6062E-06 0 0
V/A 6961 Ig-54 14 rs1213182154 0.0737 -0.282 0.002 N 0.071 0.054 0.282179105231 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/A 6961 Ig-54 14 rs1213182154 0.0737 -0.282 0.002 N 0.071 0.054 0.282179105231 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/G 6961 Ig-54 14 rs1213182154 0.1497 -0.37 0.379 N 0.371 0.135 0.602507252205 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/G 6961 Ig-54 14 rs1213182154 0.1497 -0.37 0.379 N 0.371 0.135 0.602507252205 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/G 6961 Ig-54 14 rs1213182154 0.1497 -0.37 0.379 N 0.371 0.135 0.602507252205 gnomAD-4.0.0 6.57592E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47098E-05 0 0
V/I 6961 Ig-54 14 rs1268803689 0.0819 -0.159 0.004 N 0.219 0.094 0.276482976112 gnomAD-2.1.1 4.05E-06 None None None None I None 0 2.92E-05 None 0 0 None 0 None 0 0 0
V/I 6961 Ig-54 14 rs1268803689 0.0819 -0.159 0.004 N 0.219 0.094 0.276482976112 gnomAD-4.0.0 3.20957E-06 None None None None I None 0 2.29632E-05 None 0 0 None 0 0 0 1.43848E-05 0
L/F 7057 Ig-55 14 None 0.101 None 0.994 N 0.341 0.19 0.336892272479 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 7150 Ig-56 14 rs1248770778 0.2095 None 0.896 N 0.404 0.265 0.184867976434 gnomAD-4.0.0 3.21365E-06 None None None None I None 0 0 None 0 0 None 0 0 2.88063E-06 0 3.04971E-05
P/L 7243 Ig-57 14 rs193060723 0.0929 -0.533 0.27 N 0.408 0.066 None gnomAD-2.1.1 8.1E-06 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 0
P/L 7243 Ig-57 14 rs193060723 0.0929 -0.533 0.27 N 0.408 0.066 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96644E-04 0 0 0 None 0 0 0 0 0
P/L 7243 Ig-57 14 rs193060723 0.0929 -0.533 0.27 N 0.408 0.066 None 1000 genomes 3.99361E-04 None None None None N None 0 2.9E-03 None None 0 0 None None None 0 None
P/L 7243 Ig-57 14 rs193060723 0.0929 -0.533 0.27 N 0.408 0.066 None gnomAD-4.0.0 8.67717E-06 None None None None N None 0 2.16717E-04 None 0 0 None 0 0 0 1.09847E-05 0
P/S 7243 Ig-57 14 None 0.1227 None 0.27 N 0.405 0.039 0.112648838833 gnomAD-4.0.0 1.59201E-06 None None None None N None 0 2.28697E-05 None 0 0 None 0 0 0 0 0
V/A 7336 Ig-58 14 rs1323509026 0.0882 -0.335 0.012 N 0.095 0.167 0.176091768786 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/G 7432 Ig-59 14 rs2078569479 0.3169 None 0.002 N 0.207 0.316 0.809727008303 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/G 7432 Ig-59 14 rs2078569479 0.3169 None 0.002 N 0.207 0.316 0.809727008303 gnomAD-4.0.0 6.57367E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
V/M 7432 Ig-59 14 rs764881933 0.1518 -0.288 0.863 N 0.271 0.37 None gnomAD-2.1.1 1.79E-05 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 2.35E-05 0
V/M 7432 Ig-59 14 rs764881933 0.1518 -0.288 0.863 N 0.271 0.37 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/M 7432 Ig-59 14 rs764881933 0.1518 -0.288 0.863 N 0.271 0.37 None gnomAD-4.0.0 7.00438E-05 None None None None I None 1.33568E-05 0 None 0 0 None 0 0 9.3255E-05 0 3.20338E-05
Q/R 7622 Ig-61 15 rs1234634855 0.1093 None 0.021 N 0.307 0.071 0.136095386433 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/R 7622 Ig-61 15 rs1234634855 0.1093 None 0.021 N 0.307 0.071 0.136095386433 gnomAD-4.0.0 2.57847E-06 None None None None N None 1.6956E-05 1.69976E-05 None 0 0 None 0 0 0 0 0
K/E 7715 Ig-62 14 None 0.4277 None 0.003 N 0.267 0.052 0.132336055621 gnomAD-4.0.0 1.59966E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86779E-06 0 0
K/T 7715 Ig-62 14 None 0.4957 None 0.173 N 0.533 0.188 0.231231049324 gnomAD-4.0.0 1.60001E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.04062E-05
I/F 7808 Ig-63 14 rs780407852 0.1645 -0.468 0.171 N 0.261 0.039 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/F 7808 Ig-63 14 rs780407852 0.1645 -0.468 0.171 N 0.261 0.039 None gnomAD-4.0.0 1.23958E-06 None None None None I None 1.33518E-05 0 None 0 0 None 0 0 8.4769E-07 0 0
I/T 7808 Ig-63 14 rs1401488041 0.0739 -0.212 0.001 N 0.241 0.09 0.360565625551 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/T 7808 Ig-63 14 rs1401488041 0.0739 -0.212 0.001 N 0.241 0.09 0.360565625551 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 9.42E-05 0 0 0 0
I/T 7808 Ig-63 14 rs1401488041 0.0739 -0.212 0.001 N 0.241 0.09 0.360565625551 gnomAD-4.0.0 5.57796E-06 None None None None I None 0 1.66706E-05 None 0 0 None 1.56299E-05 0 3.39076E-06 2.19664E-05 1.60123E-05
I/V 7808 Ig-63 14 rs780407852 0.0708 0.021 None N 0.137 0.025 0.0716867268079 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
I/V 7808 Ig-63 14 rs780407852 0.0708 0.021 None N 0.137 0.025 0.0716867268079 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 7808 Ig-63 14 rs780407852 0.0708 0.021 None N 0.137 0.025 0.0716867268079 gnomAD-4.0.0 1.23958E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69538E-06 0 0
L/Q 7998 Ig-65 14 rs1188351264 0.0864 -0.888 0.497 N 0.561 0.282 0.611542178662 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
L/Q 7998 Ig-65 14 rs1188351264 0.0864 -0.888 0.497 N 0.561 0.282 0.611542178662 gnomAD-4.0.0 1.3685E-06 None None None None I None 0 0 None 0 2.5194E-05 None 0 0 8.99541E-07 0 0
P/A 8091 Ig-66 14 None 0.1652 None 0.767 N 0.415 0.199 0.132336055621 gnomAD-4.0.0 2.05539E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70058E-06 0 0
P/L 8091 Ig-66 14 rs1418085481 0.2701 None 0.999 N 0.724 0.377 0.456647468687 gnomAD-4.0.0 1.59558E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86475E-06 0 0
I/T 8277 Ig-68 14 rs745818162 0.0905 -0.48 0.074 N 0.383 0.135 0.527404433557 gnomAD-2.1.1 1.1E-05 None None None None I None 0 0 None 0 5.14E-05 None 0 None 5.09E-05 7.83E-06 0
I/T 8277 Ig-68 14 rs745818162 0.0905 -0.48 0.074 N 0.383 0.135 0.527404433557 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
I/T 8277 Ig-68 14 rs745818162 0.0905 -0.48 0.074 N 0.383 0.135 0.527404433557 gnomAD-4.0.0 7.7693E-06 None None None None I None 0 0 None 0 7.27237E-05 None 0 0 2.39584E-06 1.3416E-05 2.85063E-05
L/F 8469 Ig-70 14 None 0.1326 None 0.893 N 0.255 0.193 0.227260227426 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Q/E 8563 Ig-71 15 None 0.078 None 0.002 N 0.147 0.038 0.126345400529 gnomAD-4.0.0 2.76474E-06 None None None None I None 0 0 None 0 0 None 0 0 3.6242E-06 0 0
V/A 8749 Ig-73 14 rs770874023 0.0653 -0.212 None N 0.139 0.052 None gnomAD-2.1.1 3.63E-05 None None None None I None 0 0 None 0 0 None 0 None 9.39E-05 6.23E-05 0
V/A 8749 Ig-73 14 rs770874023 0.0653 -0.212 None N 0.139 0.052 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 9.49367E-03 1.47E-05 0 0
V/A 8749 Ig-73 14 rs770874023 0.0653 -0.212 None N 0.139 0.052 None gnomAD-4.0.0 2.72796E-05 None None None None I None 0 1.66789E-05 None 0 0 None 3.13509E-05 6.6072E-04 2.45875E-05 3.29823E-05 8.00743E-05
V/I 8749 Ig-73 14 rs16866457 0.0658 0.002 None N 0.149 0.042 None gnomAD-2.1.1 5.20363E-03 None None None None I None 4.10006E-02 1.61803E-03 None 3.10138E-02 0 None 9.84E-05 None 0 4.69807E-04 3.24767E-03
V/I 8749 Ig-73 14 rs16866457 0.0658 0.002 None N 0.149 0.042 None gnomAD-3.1.2 1.249E-02 None None None None I None 4.10105E-02 3.60419E-03 0 2.94118E-02 0 None 0 0 3.82353E-04 0 8.61244E-03
V/I 8749 Ig-73 14 rs16866457 0.0658 0.002 None N 0.149 0.042 None 1000 genomes 1.61741E-02 None None None None I None 5.82E-02 5.8E-03 None None 0 0 None None None 0 None
V/I 8749 Ig-73 14 rs16866457 0.0658 0.002 None N 0.149 0.042 None gnomAD-4.0.0 3.01617E-03 None None None None I None 4.22047E-02 2.60156E-03 None 3.07068E-02 0 None 0 1.32188E-03 2.50112E-04 8.7943E-05 5.22084E-03
T/M 8843 Ig-74 14 rs72648990 0.0734 -0.018 0.029 N 0.227 0.138 None gnomAD-2.1.1 3.75064E-04 None None None None N None 8.27E-05 1.04959E-03 None 0 0 None 2.95005E-04 None 4E-05 3.98257E-04 7.03433E-04
T/M 8843 Ig-74 14 rs72648990 0.0734 -0.018 0.029 N 0.227 0.138 None gnomAD-3.1.2 3.22186E-04 None None None None N None 1.20726E-04 5.24178E-04 0 0 0 None 0 6.32911E-03 4.26383E-04 0 2.39923E-03
T/M 8843 Ig-74 14 rs72648990 0.0734 -0.018 0.029 N 0.227 0.138 None gnomAD-4.0.0 3.81161E-04 None None None None N None 1.73389E-04 9.0057E-04 None 0 0 None 3.1252E-05 2.97226E-03 3.78917E-04 4.06629E-04 7.04473E-04
T/R 8843 Ig-74 14 rs72648990 0.1024 -0.302 0.13 N 0.412 0.152 0.291694819147 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/R 8843 Ig-74 14 rs72648990 0.1024 -0.302 0.13 N 0.412 0.152 0.291694819147 gnomAD-4.0.0 2.05299E-06 None None None None N None 0 0 None 0 7.5582E-05 None 0 0 0 0 0
T/P 9032 Ig-76 14 None 0.062 None 0.001 N 0.09 0.18 0.144782658237 gnomAD-4.0.0 3.42281E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49869E-06 0 0
K/N 9125 Ig-77 14 rs749332790 0.2983 0.196 0.984 N 0.411 0.176 0.187945064343 gnomAD-2.1.1 4.04E-06 None None None None I None 6.49E-05 0 None 0 0 None 0 None 0 0 0
K/N 9125 Ig-77 14 rs749332790 0.2983 0.196 0.984 N 0.411 0.176 0.187945064343 gnomAD-3.1.2 1.31E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 0 0 0
K/N 9125 Ig-77 14 rs749332790 0.2983 0.196 0.984 N 0.411 0.176 0.187945064343 gnomAD-4.0.0 1.31406E-05 None None None None I None 4.82416E-05 0 None 0 0 None 0 0 0 0 0
V/A 9218 Ig-78 14 None 0.0958 None 0.001 N 0.099 0.068 0.190952846119 gnomAD-4.0.0 1.59132E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85842E-06 0 0
V/F 9218 Ig-78 14 rs746558975 0.1505 -0.641 0.927 N 0.331 0.246 0.516938183928 gnomAD-2.1.1 4.43E-05 None None None None I None 0 1.45037E-04 None 0 0 None 0 None 0 5.34E-05 0
V/F 9218 Ig-78 14 rs746558975 0.1505 -0.641 0.927 N 0.331 0.246 0.516938183928 gnomAD-3.1.2 5.26E-05 None None None None I None 0 1.96644E-04 0 0 0 None 0 0 7.35E-05 0 0
V/F 9218 Ig-78 14 rs746558975 0.1505 -0.641 0.927 N 0.331 0.246 0.516938183928 gnomAD-4.0.0 2.85069E-05 None None None None I None 2.67001E-05 1.83425E-04 None 0 0 None 0 3.28947E-04 2.54285E-05 0 1.60102E-05
V/I 9218 Ig-78 14 None 0.0676 None 0.425 N 0.377 0.106 0.202949470691 gnomAD-4.0.0 6.84227E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65645E-05
V/A 9314 Ig-79 14 rs727505348 0.1062 -0.917 0.334 N 0.305 0.151 0.324986149311 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
V/A 9314 Ig-79 14 rs727505348 0.1062 -0.917 0.334 N 0.305 0.151 0.324986149311 gnomAD-4.0.0 8.89693E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69899E-06 1.16036E-04 0
V/D 9314 Ig-79 14 rs727505348 0.3924 -0.477 0.379 N 0.357 0.199 0.591083742983 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
V/D 9314 Ig-79 14 rs727505348 0.3924 -0.477 0.379 N 0.357 0.199 0.591083742983 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
V/D 9314 Ig-79 14 rs727505348 0.3924 -0.477 0.379 N 0.357 0.199 0.591083742983 gnomAD-4.0.0 4.33875E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.59312E-05 1.60108E-05
V/I 9314 Ig-79 14 None 0.0749 None 0.004 N 0.231 0.097 0.124217242631 gnomAD-4.0.0 1.59238E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86056E-06 0 0
E/Q 9507 Ig-81 15 None 0.1706 None 0.984 None 0.449 0.304 0.28058544554 gnomAD-4.0.0 2.05297E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6984E-06 0 0
E/G 9603 Ig-82 14 None 0.2343 None 0.999 None 0.646 0.32 0.346085882481 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
E/Q 9711 Ig-83 14 rs2075957760 0.7184 None 0.999 None 0.579 0.304 0.234412748748 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/Q 9711 Ig-83 14 rs2075957760 0.7184 None 0.999 None 0.579 0.304 0.234412748748 gnomAD-4.0.0 2.02989E-06 None None None None I None 0 6.15006E-05 None 0 0 None 0 0 1.20494E-06 0 0
E/D 10091 Ig-86 14 rs2075203632 0.9315 None 0.999 None 0.448 0.217 0.12205267543 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
E/D 10091 Ig-86 14 rs2075203632 0.9315 None 0.999 None 0.448 0.217 0.12205267543 gnomAD-4.0.0 3.84252E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.02026E-05 0
E/G 10091 Ig-86 14 None 0.888 None 1.0 None 0.619 0.43 0.248417906384 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 10091 Ig-86 14 rs2075203983 0.8303 None 0.999 None 0.602 0.271 0.17258766438 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 13700 Ig-87 17 rs1438452689 0.1397 -0.624 0.104 N 0.403 0.17 0.37762505005 gnomAD-2.1.1 8.05E-06 None None None None I None 6.46E-05 2.9E-05 None 0 0 None 0 None 0 0 0
V/A 13700 Ig-87 17 rs1438452689 0.1397 -0.624 0.104 N 0.403 0.17 0.37762505005 gnomAD-3.1.2 3.29E-05 None None None None I None 0 3.2774E-04 0 0 0 None 0 0 0 0 0
V/A 13700 Ig-87 17 rs1438452689 0.1397 -0.624 0.104 N 0.403 0.17 0.37762505005 gnomAD-4.0.0 7.43819E-06 None None None None I None 1.33522E-05 1.0006E-04 None 0 0 None 0 0 2.5433E-06 1.09789E-05 1.60174E-05
V/I 13700 Ig-87 17 rs748716483 0.0838 -0.15 0.002 N 0.169 0.026 0.107399877778 gnomAD-2.1.1 1.79E-05 None None None None I None 0 2.83E-05 None 0 0 None 3.27E-05 None 0 2.35E-05 0
V/I 13700 Ig-87 17 rs748716483 0.0838 -0.15 0.002 N 0.169 0.026 0.107399877778 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 13700 Ig-87 17 rs748716483 0.0838 -0.15 0.002 N 0.169 0.026 0.107399877778 gnomAD-4.0.0 9.29791E-06 None None None None I None 0 3.33545E-05 None 0 0 None 0 0 7.62989E-06 3.29402E-05 1.60185E-05
V/L 13700 Ig-87 17 None 0.2034 None 0.022 N 0.377 0.022 0.162503812791 gnomAD-4.0.0 3.42182E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49806E-06 0 0
K/R 13794 Ig-88 15 rs944123089 0.1165 -0.05 0.1 N 0.276 0.119 0.148003135375 gnomAD-2.1.1 8.18E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.81E-05 0
K/R 13794 Ig-88 15 rs944123089 0.1165 -0.05 0.1 N 0.276 0.119 0.148003135375 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 13794 Ig-88 15 rs944123089 0.1165 -0.05 0.1 N 0.276 0.119 0.148003135375 gnomAD-4.0.0 3.7294E-06 None None None None N None 0 0 None 0 0 None 0 0 5.09773E-06 0 0
P/R 13887 Ig-89 12 rs1388854623 0.902 0.072 1.0 N 0.752 0.411 0.36076525451 gnomAD-2.1.1 8.73E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.96E-05 0
P/R 13887 Ig-89 12 rs1388854623 0.902 0.072 1.0 N 0.752 0.411 0.36076525451 gnomAD-4.0.0 4.83038E-06 None None None None I None 0 0 None 0 0 None 0 0 6.33231E-06 0 0
P/S 13887 Ig-89 12 None 0.7808 None 1.0 N 0.795 0.32 0.269558022972 gnomAD-4.0.0 1.62346E-06 None None None None I None 0 0 None 0 0 None 0 0 2.91102E-06 0 0
E/G 13978 Ig-90 14 rs1275851499 0.899 None 0.999 D 0.601 0.545 0.30921473904 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/G 13978 Ig-90 14 rs1275851499 0.899 None 0.999 D 0.601 0.545 0.30921473904 gnomAD-4.0.0 1.3148E-05 None None None None N None 4.82509E-05 0 None 0 0 None 0 0 0 0 0
E/K 13978 Ig-90 14 rs746667196 0.9404 -0.562 0.997 N 0.693 0.368 0.253205268125 gnomAD-2.1.1 2.01E-05 None None None None N None 6.46E-05 2.9E-05 None 0 0 None 0 None 0 2.67E-05 0
E/K 13978 Ig-90 14 rs746667196 0.9404 -0.562 0.997 N 0.693 0.368 0.253205268125 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
E/K 13978 Ig-90 14 rs746667196 0.9404 -0.562 0.997 N 0.693 0.368 0.253205268125 gnomAD-4.0.0 5.20708E-05 None None None None N None 1.33547E-05 1.66756E-05 None 0 0 None 0 0 6.86713E-05 0 1.60185E-05
E/G 14155 Ig-92 14 rs767378433 0.8415 -1.202 1.0 D 0.641 0.546 0.444404870569 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/G 14155 Ig-92 14 rs767378433 0.8415 -1.202 1.0 D 0.641 0.546 0.444404870569 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/G 14155 Ig-92 14 rs767378433 0.8415 -1.202 1.0 D 0.641 0.546 0.444404870569 gnomAD-4.0.0 3.04515E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61495E-06 0 0
V/A 14332 Ig-94 14 rs1286707659 0.1623 None 0.255 N 0.271 0.144 0.265929055128 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 14332 Ig-94 14 rs1286707659 0.1623 None 0.255 N 0.271 0.144 0.265929055128 gnomAD-4.0.0 2.03007E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40997E-06 0 0
E/K 14421 Ig-95 14 rs748507741 0.7637 -0.108 1.0 D 0.601 0.451 0.571414409706 gnomAD-2.1.1 2.83E-05 None None None None N None 0 2.9E-05 None 0 0 None 6.54E-05 None 0 3.58E-05 0
E/K 14421 Ig-95 14 rs748507741 0.7637 -0.108 1.0 D 0.601 0.451 0.571414409706 gnomAD-4.0.0 1.77963E-05 None None None None N None 2.98989E-05 2.23644E-05 None 0 0 None 3.76237E-05 0 9.89604E-06 1.27551E-04 0
E/D 14510 Ig-96 14 None 0.8142 None 0.999 D 0.445 0.5 0.415564226483 gnomAD-4.0.0 1.61706E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89949E-06 0 0
E/Q 14510 Ig-96 14 rs769619291 0.4748 -0.996 1.0 D 0.625 0.516 0.593630346942 gnomAD-2.1.1 4.3E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.56E-06 0
E/A 14599 Ig-97 14 None 0.4357 None 0.999 D 0.599 0.515 0.352476196916 gnomAD-4.0.0 6.84963E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6587E-05
E/G 14599 Ig-97 14 rs918346918 0.5251 None 1.0 D 0.683 0.54 0.528160237705 gnomAD-4.0.0 6.84963E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6587E-05
E/K 14599 Ig-97 14 None 0.558 None 0.999 D 0.575 0.313 0.375861065471 gnomAD-4.0.0 4.79484E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29907E-06 0 0
E/Q 14599 Ig-97 14 rs879113246 0.4076 None 1.0 D 0.622 0.269 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/Q 14599 Ig-97 14 rs879113246 0.4076 None 1.0 D 0.622 0.269 None gnomAD-4.0.0 2.48139E-06 None None None None N None 4.00609E-05 0 None 0 0 None 0 0 0 0 1.60313E-05
E/Q 14688 Ig-98 14 rs2059718388 0.7869 None 0.999 D 0.679 0.372 0.214338557667 gnomAD-4.0.0 3.42218E-06 None None None None N None 0 6.71231E-05 None 0 0 None 0 1.73671E-04 0 0 1.65744E-05
A/S 14777 Ig-99 13 None 0.1846 None 1.0 N 0.575 0.229 0.186928172975 gnomAD-4.0.0 1.59316E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02792E-05
A/T 14777 Ig-99 13 rs746862383 0.2614 -0.712 1.0 N 0.733 0.301 0.199424873507 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 15133 Ig-103 14 rs781744339 0.7971 -0.518 0.999 D 0.455 0.245 0.377274123778 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.97E-06 0
E/D 15133 Ig-103 14 rs781744339 0.7971 -0.518 0.999 D 0.455 0.245 0.377274123778 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 15133 Ig-103 14 rs781744339 0.7971 -0.518 0.999 D 0.455 0.245 0.377274123778 gnomAD-4.0.0 5.58374E-06 None None None None I None 0 0 None 0 0 None 0 0 7.63347E-06 0 0
E/Q 15133 Ig-103 14 None 0.4612 None 1.0 D 0.623 0.371 0.506552580704 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 15315 Ig-105 14 None 0.5219 None 1.0 D 0.608 0.562 0.401185642668 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
E/K 15315 Ig-105 14 rs1191106743 0.6754 -0.447 0.999 N 0.616 0.384 0.270889551736 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
E/K 15315 Ig-105 14 rs1191106743 0.6754 -0.447 0.999 N 0.616 0.384 0.270889551736 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 15315 Ig-105 14 rs1191106743 0.6754 -0.447 0.999 N 0.616 0.384 0.270889551736 gnomAD-4.0.0 3.10331E-06 None None None None N None 1.33715E-05 0 None 0 0 None 0 0 2.5456E-06 1.1005E-05 0
E/G 15404 Ig-106 14 rs878854311 0.8245 None 1.0 D 0.672 0.729 0.665719803998 gnomAD-4.0.0 1.68363E-06 None None None None N None 6.01106E-05 0 None 0 0 None 0 0 0 0 0
E/K 15404 Ig-106 14 None 0.8392 None 0.999 D 0.63 0.521 0.503002171853 gnomAD-4.0.0 1.67923E-06 None None None None N None 0 0 None 0 0 None 0 0 3.00589E-06 0 0
P/S 15493 Ig-107 14 rs1173523537 0.415 -0.982 1.0 N 0.76 0.389 0.393775345888 gnomAD-4.0.0 1.59509E-06 None None None None N None 0 2.29263E-05 None 0 0 None 0 0 0 0 0
V/A 15581 Ig-108 14 rs767913696 0.0663 -0.455 None N 0.167 0.111 0.15556083564 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
V/A 15581 Ig-108 14 rs767913696 0.0663 -0.455 None N 0.167 0.111 0.15556083564 gnomAD-4.0.0 4.11268E-06 None None None None I None 0 0 None 0 0 None 0 0 9.00275E-07 5.80707E-05 0
V/G 15581 Ig-108 14 None 0.1841 None 0.124 N 0.444 0.104 0.332386209738 gnomAD-4.0.0 6.85447E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00275E-07 0 0
V/I 15581 Ig-108 14 rs2057792171 0.0872 None 0.104 N 0.404 0.128 0.279776271856 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 9.41E-05 0 0 0 0
V/I 15581 Ig-108 14 rs2057792171 0.0872 None 0.104 N 0.404 0.128 0.279776271856 gnomAD-4.0.0 6.58233E-06 None None None None I None 0 0 None 0 0 None 9.40911E-05 0 0 0 0
V/A 15976 Ig-109 9 rs2057447237 0.3799 None 0.999 N 0.556 0.31 0.511047945453 gnomAD-4.0.0 7.96706E-06 None None None None N None 0 0 None 0 0 None 0 0 1.43142E-05 0 0
A/T 16272 Ig-110 11 None 0.5277 None 1.0 N 0.721 0.276 0.238096912614 gnomAD-4.0.0 1.59525E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86441E-06 0 0
R/Q 17261 Ig-112 11 rs201825412 0.1324 -0.129 0.164 N 0.226 0.049 None gnomAD-2.1.1 1.15139E-04 None None None None N None 8.28E-05 5.67E-05 None 0 0 None 0 None 0 2.13594E-04 1.41084E-04
R/Q 17261 Ig-112 11 rs201825412 0.1324 -0.129 0.164 N 0.226 0.049 None gnomAD-3.1.2 1.51419E-04 None None None None N None 2.41E-05 6.57E-05 0 0 0 None 0 0 2.94481E-04 0 4.78927E-04
R/Q 17261 Ig-112 11 rs201825412 0.1324 -0.129 0.164 N 0.226 0.049 None gnomAD-4.0.0 3.01478E-04 None None None None N None 5.34745E-05 3.33834E-05 None 3.38685E-05 0 None 0 0 3.9953E-04 0 1.2823E-04
A/S 17686 Ig-113 10 rs1576364760 0.2724 None 0.998 N 0.551 0.252 0.16115917748 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94553E-04 None 0 0 0 0 0
A/S 17686 Ig-113 10 rs1576364760 0.2724 None 0.998 N 0.551 0.252 0.16115917748 gnomAD-4.0.0 3.84634E-06 None None None None N None 0 0 None 0 2.43202E-05 None 0 0 0 2.68082E-05 0
E/D 18698 Ig-116 11 None 0.5117 None 0.999 N 0.462 0.254 0.316788114976 gnomAD-4.0.0 1.37783E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80515E-06 0 0
A/T 19106 Ig-117 12 rs754573037 0.2724 -0.637 1.0 N 0.693 0.371 0.358948522604 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.57E-05 0
A/T 19106 Ig-117 12 rs754573037 0.2724 -0.637 1.0 N 0.693 0.371 0.358948522604 gnomAD-4.0.0 1.27402E-05 None None None None I None 0 2.28948E-05 None 0 0 None 0 0 2.00189E-05 0 0
V/A 19400 Ig-118 10 None 0.1378 None 0.928 N 0.437 0.26 0.41958645093 gnomAD-4.0.0 4.10641E-06 None None None None I None 2.98864E-05 0 None 3.8279E-05 0 None 0 0 2.69876E-06 0 1.65706E-05
V/G 19400 Ig-118 10 rs774737543 0.378 -1.068 0.989 N 0.78 0.519 0.686624564747 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/G 19400 Ig-118 10 rs774737543 0.378 -1.068 0.989 N 0.78 0.519 0.686624564747 gnomAD-4.0.0 4.79081E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39752E-06 0 1.65706E-05
V/A 19800 Ig-119 11 rs747359962 0.0762 None 0.002 N 0.111 0.131 0.247322355667 gnomAD-4.0.0 1.02654E-05 None None None None N None 0 0 None 0 0 None 0 0 1.34938E-05 0 0
A/G 20092 Ig-120 13 rs1276745153 0.4782 -0.506 1.0 N 0.549 0.434 0.440498838766 gnomAD-2.1.1 4.26E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.24E-06 0
A/G 20092 Ig-120 13 rs1276745153 0.4782 -0.506 1.0 N 0.549 0.434 0.440498838766 gnomAD-4.0.0 6.91419E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04231E-07 0 0
A/T 20092 Ig-120 13 None 0.4696 None 1.0 N 0.707 0.433 0.350088858571 gnomAD-4.0.0 1.63377E-06 None None None None N None 0 0 None 0 0 None 1.93043E-05 0 0 0 0
A/V 20092 Ig-120 13 rs1276745153 0.4772 None 1.0 N 0.637 0.425 0.380394304726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 20092 Ig-120 13 rs1276745153 0.4772 None 1.0 N 0.637 0.425 0.380394304726 gnomAD-4.0.0 1.2513E-06 None None None None N None 0 0 None 0 0 None 0 0 1.70371E-06 0 0
V/A 20490 Ig-121 12 None 0.1586 None 0.999 N 0.503 0.34 0.46614307118 gnomAD-4.0.0 3.49814E-06 None None None None I None 0 0 None 0 0 None 0 0 4.56086E-06 0 0
V/I 20490 Ig-121 12 rs777345561 0.1493 -0.369 0.997 N 0.463 0.276 0.506673610527 gnomAD-2.1.1 4.53E-06 None None None None I None 0 0 None 0 0 None 4.37E-05 None 0 0 0
V/I 20490 Ig-121 12 rs777345561 0.1493 -0.369 0.997 N 0.463 0.276 0.506673610527 gnomAD-4.0.0 1.39927E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.51978E-05 0
A/G 21188 Ig-123 12 rs746456662 0.3712 -0.248 0.067 D 0.369 0.371 0.212008924253 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
A/G 21188 Ig-123 12 rs746456662 0.3712 -0.248 0.067 D 0.369 0.371 0.212008924253 gnomAD-4.0.0 1.59493E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86411E-06 0 0
A/P 21188 Ig-123 12 None 0.9462 None 0.998 N 0.735 0.463 0.273070737957 gnomAD-4.0.0 1.36986E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80019E-06 0 0
A/T 21188 Ig-123 12 None 0.4392 None 0.994 N 0.732 0.401 0.227260227426 gnomAD-4.0.0 6.84928E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.6587E-05
A/T 21480 Ig-124 12 None 0.3735 None 1.0 N 0.703 0.291 0.225902525712 gnomAD-4.0.0 6.85782E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00774E-07 0 0
A/S 21877 Ig-125 12 rs72646866 0.2568 -0.574 1.0 N 0.547 0.259 0.20549828249 gnomAD-2.1.1 1.01548E-04 None None None None I None 0 0 None 0 0 None 5.90667E-04 None 0 5.41E-05 1.67168E-04
A/S 21877 Ig-125 12 rs72646866 0.2568 -0.574 1.0 N 0.547 0.259 0.20549828249 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 6.21375E-04 0
A/S 21877 Ig-125 12 rs72646866 0.2568 -0.574 1.0 N 0.547 0.259 0.20549828249 Taylor (2011) None ARVC het None None I Genetic analysis of TTN in 38 ARVC families, incomplete penetrance None None None None None None None None None None None
A/S 21877 Ig-125 12 rs72646866 0.2568 -0.574 1.0 N 0.547 0.259 0.20549828249 gnomAD-4.0.0 5.70925E-05 None None None None I None 0 0 None 0 0 None 0 9.8912E-04 1.78194E-05 6.60429E-04 8.01847E-05
A/V 21877 Ig-125 12 None 0.6521 None 1.0 N 0.627 0.353 0.250039746154 gnomAD-4.0.0 1.59665E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86849E-06 0 0
A/P 22275 Ig-126 11 None 0.9264 None 1.0 N 0.763 0.502 0.32714864917 gnomAD-4.0.0 1.20034E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
A/V 22275 Ig-126 11 rs781002289 0.6922 -0.233 1.0 N 0.638 0.369 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.12778E-04 None 0 None 0 8.96E-06 0
A/V 22275 Ig-126 11 rs781002289 0.6922 -0.233 1.0 N 0.638 0.369 None gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/D 22564 Ig-127 5 None 0.5994 None 0.999 N 0.407 0.315 0.240491677333 gnomAD-4.0.0 1.6116E-06 None None None None I None 0 0 None 0 0 None 0 0 2.89024E-06 0 0
E/G 22564 Ig-127 5 rs559039977 0.4945 -0.902 1.0 N 0.679 0.511 0.507867570733 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 0 None 3.33E-05 None 0 0 0
E/G 22564 Ig-127 5 rs559039977 0.4945 -0.902 1.0 N 0.679 0.511 0.507867570733 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
E/G 22564 Ig-127 5 rs559039977 0.4945 -0.902 1.0 N 0.679 0.511 0.507867570733 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
E/G 22564 Ig-127 5 rs559039977 0.4945 -0.902 1.0 N 0.679 0.511 0.507867570733 gnomAD-4.0.0 6.56987E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.07211E-04 0
E/K 22564 Ig-127 5 rs2047149895 0.5204 None 0.999 N 0.537 0.367 0.362758974969 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 9.42E-05 0 0 0 0
E/K 22564 Ig-127 5 rs2047149895 0.5204 None 0.999 N 0.537 0.367 0.362758974969 gnomAD-4.0.0 6.57748E-06 None None None None I None 0 0 None 0 0 None 9.42329E-05 0 0 0 0
A/G 22960 Ig-128 11 None 0.3729 None 1.0 N 0.539 0.404 0.24896430686 gnomAD-4.0.0 1.37942E-06 None None None None N None 0 0 None 0 0 None 0 0 9.05686E-07 0 1.67012E-05
A/T 22960 Ig-128 11 None 0.3542 None 1.0 N 0.723 0.318 0.18274738541 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 23647 Ig-130 11 rs1447481220 0.291 -0.712 1.0 N 0.697 0.282 0.239901079897 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
A/T 23647 Ig-130 11 rs1447481220 0.291 -0.712 1.0 N 0.697 0.282 0.239901079897 gnomAD-4.0.0 2.05403E-06 None None None None N None 2.98882E-05 0 None 0 0 None 0 0 0 1.16104E-05 1.65772E-05
A/S 24043 Ig-131 15 rs760621388 0.1671 -0.15 1.0 N 0.571 0.21 0.170165803431 gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
A/S 24043 Ig-131 15 rs760621388 0.1671 -0.15 1.0 N 0.571 0.21 0.170165803431 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/S 24043 Ig-131 15 rs760621388 0.1671 -0.15 1.0 N 0.571 0.21 0.170165803431 gnomAD-4.0.0 2.5636E-06 None None None None I None 3.38398E-05 0 None 0 0 None 0 0 0 0 0
A/T 24043 Ig-131 15 None 0.2925 None 1.0 N 0.741 0.29 0.191931220699 gnomAD-4.0.0 1.59219E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85943E-06 0 0
A/V 24043 Ig-131 15 None 0.2877 None 1.0 N 0.661 0.321 0.321108458156 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/D 24442 Ig-132 12 rs878960037 0.9486 None 0.998 N 0.747 0.468 None gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
A/D 24442 Ig-132 12 rs878960037 0.9486 None 0.998 N 0.747 0.468 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/D 24442 Ig-132 12 rs878960037 0.9486 None 0.998 N 0.747 0.468 None gnomAD-4.0.0 6.57635E-06 None None None None I None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
A/G 24442 Ig-132 12 None 0.4493 None 0.979 N 0.563 0.338 0.306053231325 gnomAD-4.0.0 2.73743E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59847E-06 0 0
A/T 24442 Ig-132 12 rs764005465 0.6973 -0.897 0.958 N 0.667 0.307 0.283371740733 gnomAD-2.1.1 8.06E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 8.92E-06 0
A/T 24442 Ig-132 12 rs764005465 0.6973 -0.897 0.958 N 0.667 0.307 0.283371740733 gnomAD-4.0.0 1.59206E-06 None None None None I None 0 2.28707E-05 None 0 0 None 0 0 0 0 0
A/V 24442 Ig-132 12 None 0.7698 None 0.142 N 0.385 0.31 0.335414705075 gnomAD-4.0.0 3.42179E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49809E-06 0 0
A/T 24729 Ig-133 14 rs372007344 0.2295 -0.502 1.0 N 0.624 0.354 None gnomAD-2.1.1 2.51E-05 None None None None I None 4.14E-05 0 None 0 0 None 0 None 0 4.7E-05 0
A/T 24729 Ig-133 14 rs372007344 0.2295 -0.502 1.0 N 0.624 0.354 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
A/T 24729 Ig-133 14 rs372007344 0.2295 -0.502 1.0 N 0.624 0.354 None gnomAD-4.0.0 1.36376E-05 None None None None I None 1.33547E-05 0 None 0 0 None 0 0 1.78028E-05 0 0
A/V 24729 Ig-133 14 rs1162562703 0.2143 -0.291 1.0 N 0.541 0.39 0.305086939656 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/V 24729 Ig-133 14 rs1162562703 0.2143 -0.291 1.0 N 0.541 0.39 0.305086939656 gnomAD-4.0.0 3.18464E-06 None None None None I None 0 0 None 4.77008E-05 0 None 0 0 0 1.43295E-05 0
A/S 25125 Ig-134 15 rs764929320 0.1601 -0.814 0.979 N 0.531 0.25 0.200317383148 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
A/S 25125 Ig-134 15 rs764929320 0.1601 -0.814 0.979 N 0.531 0.25 0.200317383148 gnomAD-4.0.0 1.5917E-06 None None None None I None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
A/T 25524 Ig-135 11 rs766397845 0.4483 -0.622 0.996 N 0.636 0.217 0.148003135375 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 5.63E-05 None 0 None 0 0 0
V/I 25811 Ig-136 14 rs1295057391 0.0964 -0.418 0.025 N 0.295 0.118 0.242825505644 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66667E-04
V/I 25811 Ig-136 14 rs1295057391 0.0964 -0.418 0.025 N 0.295 0.118 0.242825505644 gnomAD-4.0.0 4.77672E-06 None None None None N None 0 0 None 0 2.78025E-05 None 0 0 0 1.43336E-05 3.02572E-05
A/T 26207 Ig-137 15 None 0.4895 None 1.0 N 0.725 0.348 0.236278675362 gnomAD-4.0.0 1.59445E-06 None None None None I None 0 0 None 0 0 None 1.88558E-05 0 0 0 0
A/D 26606 Ig-138 13 rs779734456 0.9173 -0.37 0.998 N 0.747 0.515 0.42130639912 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.87E-06 0
A/G 26606 Ig-138 13 rs779734456 0.3958 None 0.979 N 0.581 0.354 0.311691414656 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
A/G 26893 Ig-139 14 rs1273776382 0.152 None 0.826 N 0.44 0.283 0.246215685461 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.77555E-04
A/G 26893 Ig-139 14 rs1273776382 0.152 None 0.826 N 0.44 0.283 0.246215685461 gnomAD-4.0.0 2.56383E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39404E-06 0 2.84706E-05
A/S 27689 Ig-141 14 rs761181487 0.1492 None 1.0 N 0.578 0.313 0.323886383625 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/S 27689 Ig-141 14 rs761181487 0.1492 None 1.0 N 0.578 0.313 0.323886383625 gnomAD-4.0.0 1.85925E-06 None None None None I None 1.33529E-05 0 None 0 0 None 0 0 1.69533E-06 0 0
A/T 27689 Ig-141 14 None 0.5443 -0.616 1.0 N 0.711 0.397 0.36036328697 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/T 27689 Ig-141 14 None 0.5443 -0.616 1.0 N 0.711 0.397 0.36036328697 gnomAD-4.0.0 6.84243E-07 None None None None I None 0 2.23604E-05 None 0 0 None 0 0 0 0 0
A/V 27689 Ig-141 14 None 0.6647 None 1.0 N 0.637 0.387 0.391000631824 gnomAD-4.0.0 1.59143E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
A/G 27976 Ig-142 14 None 0.182 None 0.958 N 0.483 0.304 0.191931220699 gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25002E-06 0 0
A/T 27976 Ig-142 14 rs879219359 0.1606 -1.44 0.958 N 0.677 0.317 None gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
A/T 27976 Ig-142 14 rs879219359 0.1606 -1.44 0.958 N 0.677 0.317 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 27976 Ig-142 14 rs879219359 0.1606 -1.44 0.958 N 0.677 0.317 None gnomAD-4.0.0 1.11628E-05 None None None None N None 1.33668E-05 0 None 0 0 None 0 0 1.44142E-05 0 0
A/D 28768 Ig-144 14 None 0.6605 None 0.011 N 0.328 0.26 0.401042353794 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
A/P 28768 Ig-144 14 None 0.8959 None 0.984 N 0.457 0.252 0.241078983079 gnomAD-4.0.0 6.85651E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99594E-07 0 0
A/S 28768 Ig-144 14 rs768347250 0.1095 None 0.103 N 0.281 0.117 0.141422826196 gnomAD-4.0.0 1.3713E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
A/T 28768 Ig-144 14 rs768347250 0.2635 None 0.811 N 0.441 0.231 0.213573922156 gnomAD-4.0.0 1.3713E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
A/G 29058 Ig-145 14 rs768069933 0.2225 -0.299 1.0 N 0.548 0.383 0.325263233342 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
A/G 29058 Ig-145 14 rs768069933 0.2225 -0.299 1.0 N 0.548 0.383 0.325263233342 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/G 29058 Ig-145 14 rs768069933 0.2225 -0.299 1.0 N 0.548 0.383 0.325263233342 gnomAD-4.0.0 4.83402E-05 None None None None I None 0 0 None 0 0 None 0 0 6.35688E-05 0 4.80323E-05
A/S 29058 Ig-145 14 None 0.1238 None 1.0 N 0.559 0.247 0.241078983079 gnomAD-4.0.0 1.59173E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85806E-06 0 0
A/V 29058 Ig-145 14 rs768069933 0.1678 -0.237 1.0 N 0.648 0.398 0.299086750705 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 0 0
A/V 29058 Ig-145 14 rs768069933 0.1678 -0.237 1.0 N 0.648 0.398 0.299086750705 gnomAD-4.0.0 1.3686E-06 None None None None I None 0 0 None 0 2.52156E-05 None 0 0 0 0 1.65656E-05
A/T 29853 Ig-147 12 rs1337052263 0.333 None 1.0 N 0.721 0.326 0.253726318573 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 29853 Ig-147 12 rs1337052263 0.333 None 1.0 N 0.721 0.326 0.253726318573 gnomAD-4.0.0 6.57142E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
I/N 30145 Ig-148 14 rs751359750 0.4242 -0.1 0.999 N 0.672 0.422 0.609245221294 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
I/N 30145 Ig-148 14 rs751359750 0.4242 -0.1 0.999 N 0.672 0.422 0.609245221294 gnomAD-4.0.0 1.37205E-06 None None None None I None 0 4.48149E-05 None 0 0 None 0 0 0 0 0
I/T 30145 Ig-148 14 rs751359750 0.145 -0.455 0.989 N 0.526 0.35 0.501060295512 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 2.68E-05 0
I/T 30145 Ig-148 14 rs751359750 0.145 -0.455 0.989 N 0.526 0.35 0.501060295512 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 30145 Ig-148 14 rs751359750 0.145 -0.455 0.989 N 0.526 0.35 0.501060295512 gnomAD-4.0.0 1.3666E-05 None None None None I None 0 0 None 0 0 None 0 0 1.69966E-05 2.19935E-05 0
S/F 30540 Ig-149 9 rs770769474 0.3388 -1.076 0.773 N 0.451 0.407 0.410071178582 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/F 30540 Ig-149 9 rs770769474 0.3388 -1.076 0.773 N 0.451 0.407 0.410071178582 gnomAD-3.1.2 1.32E-05 None None None None I None 0 1.31199E-04 0 0 0 None 0 0 0 0 0
S/F 30540 Ig-149 9 rs770769474 0.3388 -1.076 0.773 N 0.451 0.407 0.410071178582 gnomAD-4.0.0 4.33875E-06 None None None None I None 0 6.67089E-05 None 0 0 None 0 0 2.54309E-06 0 0
A/S 30939 Ig-150 13 rs773375451 0.1264 -0.111 0.91 N 0.483 0.169 0.194818534648 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/T 30939 Ig-150 13 None 0.2931 None 0.961 N 0.411 0.208 0.221734844693 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 31629 Ig-152 9 rs758521497 0.6644 -0.807 1.0 N 0.709 0.342 0.188950314367 gnomAD-2.1.1 2.51E-05 None None None None I None 8.27E-05 1.41675E-04 None 0 0 None 0 None 0 0 0
A/T 31629 Ig-152 9 rs758521497 0.6644 -0.807 1.0 N 0.709 0.342 0.188950314367 gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
A/T 31629 Ig-152 9 rs758521497 0.6644 -0.807 1.0 N 0.709 0.342 0.188950314367 gnomAD-4.0.0 6.81714E-06 None None None None I None 6.67592E-05 1.00037E-04 None 0 0 None 0 0 0 0 0
A/T 32028 Ig-153 12 rs1196335652 0.4758 -0.791 0.992 N 0.637 0.355 0.207176502487 gnomAD-2.1.1 7.15E-06 None None None None I None 0 0 None 0 1.02449E-04 None 0 None 0 0 0
A/T 32028 Ig-153 12 rs1196335652 0.4758 -0.791 0.992 N 0.637 0.355 0.207176502487 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.92753E-04 None 0 0 0 0 0
A/T 32028 Ig-153 12 rs1196335652 0.4758 -0.791 0.992 N 0.637 0.355 0.207176502487 gnomAD-4.0.0 2.47935E-06 None None None None I None 0 0 None 0 8.91305E-05 None 0 0 0 0 0
A/P 32320 Ig-154 14 None 0.8089 None 0.983 N 0.429 0.249 0.242244723065 gnomAD-4.0.0 1.59217E-06 None None None None I None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
A/S 32320 Ig-154 14 rs753692640 0.1454 -0.424 0.722 N 0.439 0.111 0.158396225186 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
A/S 32320 Ig-154 14 rs753692640 0.1454 -0.424 0.722 N 0.439 0.111 0.158396225186 gnomAD-4.0.0 1.59217E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86082E-06 0 0
L/F 33114 Ig-156 14 rs1203503394 0.4814 -1.837 1.0 N 0.659 0.174 0.473065174198 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
L/F 33114 Ig-156 14 rs1203503394 0.4814 -1.837 1.0 N 0.659 0.174 0.473065174198 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 2.88351E-04 0 None 0 0 0 0 0
L/F 33114 Ig-156 14 rs1203503394 0.4814 -1.837 1.0 N 0.659 0.174 0.473065174198 gnomAD-4.0.0 3.84546E-06 None None None None N None 1.69285E-05 0 None 4.09433E-05 0 None 0 2.24417E-04 0 0 0
V/G 33210 Ig-157 8 rs1482941539 0.2719 -1.871 0.898 N 0.411 0.172 0.724417562041 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/M 33210 Ig-157 8 None 0.171 None 0.993 N 0.36 0.19 0.340992353424 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/H 33509 Ig-158 14 rs1404850899 0.2486 -0.987 0.903 N 0.389 0.235 0.400756358115 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
Y/H 33509 Ig-158 14 rs1404850899 0.2486 -0.987 0.903 N 0.389 0.235 0.400756358115 gnomAD-4.0.0 1.59254E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86023E-06 0 0
R/P 33609 Ig-159 14 rs771243505 0.812 -0.282 1.0 N 0.703 0.466 0.262662153117 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.76E-05 0 0
R/P 33609 Ig-159 14 rs771243505 0.812 -0.282 1.0 N 0.703 0.466 0.262662153117 gnomAD-4.0.0 6.8475E-07 None None None None N None 0 0 None 0 0 None 1.90172E-05 0 0 0 0
R/Q 33609 Ig-159 14 rs771243505 0.2078 -0.355 1.0 N 0.696 0.33 0.18274738541 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 8.94E-06 1.66334E-04
R/Q 33609 Ig-159 14 rs771243505 0.2078 -0.355 1.0 N 0.696 0.33 0.18274738541 gnomAD-3.1.2 4.62E-05 None None None None N None 4.86E-05 1.97083E-04 0 0 0 None 0 0 1.47E-05 0 4.79386E-04
R/Q 33609 Ig-159 14 rs771243505 0.2078 -0.355 1.0 N 0.696 0.33 0.18274738541 gnomAD-4.0.0 1.30282E-05 None None None None N None 4.02059E-05 5.00584E-05 None 0 2.23065E-05 None 0 1.64474E-04 7.63055E-06 2.19713E-05 3.20369E-05
E/A 34149 Ig-160 13 None 0.2285 None 0.999 N 0.581 0.505 0.32980341726 gnomAD-4.0.0 6.84156E-07 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 0 0
E/G 34149 Ig-160 13 rs1165341799 0.4002 None 1.0 N 0.631 0.582 0.435808882951 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 34149 Ig-160 13 rs1165341799 0.4002 None 1.0 N 0.631 0.582 0.435808882951 gnomAD-4.0.0 2.47854E-06 None None None None N None 1.33469E-05 0 None 0 0 None 0 0 2.54266E-06 0 0
E/K 34149 Ig-160 13 rs780580255 0.2588 0.312 0.999 N 0.582 0.393 0.346768085243 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/K 34149 Ig-160 13 rs780580255 0.2588 0.312 0.999 N 0.582 0.393 0.346768085243 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 34149 Ig-160 13 rs780580255 0.2588 0.312 0.999 N 0.582 0.393 0.346768085243 gnomAD-4.0.0 4.95711E-06 None None None None N None 0 1.66672E-05 None 0 0 None 0 0 5.93285E-06 0 0
V/A 34271 Ig-161 14 None 0.1094 None 0.09 N 0.306 0.147 0.278143212241 gnomAD-4.0.0 1.59095E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
V/I 34271 Ig-161 14 rs794727542 0.0643 -0.102 None N 0.095 0.06 0.104622674875 gnomAD-2.1.1 8.03E-06 None None None None N None 0 2.9E-05 None 0 5.57E-05 None 0 None 0 0 0
V/I 34271 Ig-161 14 rs794727542 0.0643 -0.102 None N 0.095 0.06 0.104622674875 gnomAD-4.0.0 2.73664E-06 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 0 0 4.96952E-05
V/L 34271 Ig-161 14 rs794727542 0.1347 -0.079 0.015 N 0.244 0.049 0.112648838833 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
V/L 34271 Ig-161 14 rs794727542 0.1347 -0.079 0.015 N 0.244 0.049 0.112648838833 gnomAD-4.0.0 2.05248E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69824E-06 0 0
E/V 34376 Ig-162 14 None 0.7922 None 1.0 D 0.69 0.613 0.704318944212 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/G 34955 Ig-163 14 rs768740635 0.1165 -2.169 0.007 N 0.369 0.117 0.178374595973 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 3.30469E-04
C/G 34955 Ig-163 14 rs768740635 0.1165 -2.169 0.007 N 0.369 0.117 0.178374595973 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/G 34955 Ig-163 14 rs768740635 0.1165 -2.169 0.007 N 0.369 0.117 0.178374595973 gnomAD-4.0.0 5.57664E-06 None None None None N None 0 0 None 0 0 None 0 3.28731E-04 5.08522E-06 0 1.60087E-05
C/S 34955 Ig-163 14 None 0.1105 None None N 0.137 0.073 0.0846915920261 gnomAD-4.0.0 6.84141E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65634E-05
E/K 35142 Ig-164 14 rs765274398 0.2161 -0.016 1.0 N 0.601 0.405 0.304435445954 gnomAD-2.1.1 3.21E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 5.32E-05 0
E/K 35142 Ig-164 14 rs765274398 0.2161 -0.016 1.0 N 0.601 0.405 0.304435445954 gnomAD-3.1.2 4.6E-05 None None None None N None 1.20662E-04 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 35142 Ig-164 14 rs765274398 0.2161 -0.016 1.0 N 0.601 0.405 0.304435445954 gnomAD-4.0.0 2.41656E-05 None None None None N None 8.00897E-05 0 None 0 0 None 0 1.64366E-04 2.3731E-05 3.29345E-05 1.60092E-05
E/D 35299 Ig-165 14 rs886055219 0.056 None None N 0.071 0.084 0.0297737177859 gnomAD-4.0.0 8.20981E-06 None None None None N None 0 0 None 0 0 None 0 0 1.07928E-05 0 0
S/L 35433 Ig-166 14 None 0.0961 None 0.085 N 0.391 0.115 0.278143212241 gnomAD-4.0.0 1.59112E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
E/K 35620 Ig-167 14 rs377593605 0.11 -0.035 0.001 N 0.133 0.057 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 2.66E-05 0
E/K 35620 Ig-167 14 rs377593605 0.11 -0.035 0.001 N 0.133 0.057 None gnomAD-3.1.2 3.94E-05 None None None None N None 1.20604E-04 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 35620 Ig-167 14 rs377593605 0.11 -0.035 0.001 N 0.133 0.057 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
E/K 35620 Ig-167 14 rs377593605 0.11 -0.035 0.001 N 0.133 0.057 None gnomAD-4.0.0 1.48699E-05 None None None None N None 6.66134E-05 0 None 0 2.22777E-05 None 0 0 1.18657E-05 4.39155E-05 0
E/D 35715 Ig-168 14 rs1687608057 0.4906 None 0.117 N 0.373 0.061 0.177238962908 gnomAD-4.0.0 1.59417E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43662E-05 0
E/G 35715 Ig-168 14 rs1196336342 0.4202 0.186 0.993 N 0.628 0.477 0.431822907236 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.97E-06 0
E/K 35910 Ig-169 14 rs370649675 0.1774 0.199 0.98 N 0.422 0.302 None gnomAD-2.1.1 1.21E-05 None None None -0.03(OBSL1) 0.032(OBSCN) N None 1.29836E-04 2.92E-05 None 0 0 None 0 None 0 0 0
E/K 35910 Ig-169 14 rs370649675 0.1774 0.199 0.98 N 0.422 0.302 None gnomAD-3.1.2 3.94E-05 None None None -0.03(OBSL1) 0.032(OBSCN) N None 1.2072E-04 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 35910 Ig-169 14 rs370649675 0.1774 0.199 0.98 N 0.422 0.302 None 1000 genomes 1.99681E-04 None None None -0.03(OBSL1) 0.032(OBSCN) N None 8E-04 0 None None 0 0 None None None 0 None
E/K 35910 Ig-169 14 rs370649675 0.1774 0.199 0.98 N 0.422 0.302 None gnomAD-4.0.0 6.82594E-06 None None None -0.03(OBSL1) 0.032(OBSCN) N None 9.33806E-05 3.3399E-05 None 0 0 None 0 0 0 0 3.20657E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.