Structural position:

  • Domain Type: Ig
  • Aligned Position: 28
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
A/T 23 Ig-1 18 rs147812158 0.2333 -1.267 1.0 D 0.709 0.432 None gnomAD-2.1.1 3.98E-06 None None None -1.279(TCAP) N None 6.16E-05 0 None 0 0 None 0 None 0 0 0
A/T 23 Ig-1 18 rs147812158 0.2333 -1.267 1.0 D 0.709 0.432 None gnomAD-3.1.2 1.97E-05 None None None -1.279(TCAP) N None 2.41E-05 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
A/T 23 Ig-1 18 rs147812158 0.2333 -1.267 1.0 D 0.709 0.432 None gnomAD-4.0.0 9.29486E-06 None None None -1.279(TCAP) N None 1.33522E-05 1.66722E-05 None 0 1.55999E-04 None 0 0 4.23748E-06 1.09849E-05 0
V/I 960 Ig-3 18 None 0.1484 None 0.046 D 0.243 0.256 0.493628743246 gnomAD-4.0.0 1.36821E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79868E-06 0 0
V/L 960 Ig-3 18 None 0.8142 None 0.046 N 0.242 0.357 0.411001663086 gnomAD-4.0.0 6.84104E-07 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 0 0 0
V/M 1099 Ig-4 18 rs368282893 0.2806 -0.435 0.908 N 0.711 0.197 None gnomAD-2.1.1 3.19E-05 None None None None N None 0 8.47E-05 None 0 0 None 0 None 0 4.65E-05 0
V/M 1099 Ig-4 18 rs368282893 0.2806 -0.435 0.908 N 0.711 0.197 None gnomAD-3.1.2 5.92E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 7.35E-05 0 0
V/M 1099 Ig-4 18 rs368282893 0.2806 -0.435 0.908 N 0.711 0.197 None gnomAD-4.0.0 5.88565E-05 None None None None N None 1.19952E-04 4.99933E-05 None 0 0 None 0 4.94886E-04 6.35592E-05 1.09796E-05 6.39939E-05
V/A 1308 Ig-5 18 None 0.4235 None 0.003 N 0.295 0.182 0.341226946553 gnomAD-4.0.0 1.20043E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31262E-06 0 0
A/G 1474 Ig-6 18 rs367739896 0.4487 -1.304 1.0 D 0.557 0.569 0.661867001231 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 6.53E-05 None 0 0 0
A/G 1474 Ig-6 18 rs367739896 0.4487 -1.304 1.0 D 0.557 0.569 0.661867001231 gnomAD-4.0.0 4.78878E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11519E-05 0
A/T 1474 Ig-6 18 None 0.3841 None 1.0 D 0.683 0.573 0.608471955132 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 1474 Ig-6 18 rs367739896 0.3605 0.109 1.0 N 0.589 0.501 None gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
L/V 1573 Ig-7 18 rs2092329719 0.1441 None 0.122 N 0.283 0.231 0.178374595973 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78469E-04
L/V 1573 Ig-7 18 rs2092329719 0.1441 None 0.122 N 0.283 0.231 0.178374595973 gnomAD-4.0.0 3.04489E-06 None None None None N None 1.74782E-05 0 None 0 0 None 0 0 0 0 6.8055E-05
A/T 1720 Ig-8 18 rs1183072143 0.219 -1.113 0.885 D 0.611 0.546 0.395595088485 gnomAD-2.1.1 7.09E-06 None None None None N None 8.01E-05 0 None 0 0 None 0 None 0 0 0
A/T 1720 Ig-8 18 rs1183072143 0.219 -1.113 0.885 D 0.611 0.546 0.395595088485 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
A/T 1720 Ig-8 18 rs1183072143 0.219 -1.113 0.885 D 0.611 0.546 0.395595088485 gnomAD-4.0.0 3.09791E-06 None None None None N None 6.67236E-05 0 None 0 0 None 0 0 0 0 0
A/E 2192 Ig-11 19 None 0.9484 None 0.995 N 0.839 0.287 0.27855597813 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
A/T 2192 Ig-11 19 rs774574739 0.2889 -1.516 0.905 N 0.69 0.217 0.132336055621 gnomAD-2.1.1 2.79E-05 None None None None N None 0 2.02511E-04 None 0 0 None 0 None 0 0 0
A/T 2192 Ig-11 19 rs774574739 0.2889 -1.516 0.905 N 0.69 0.217 0.132336055621 gnomAD-3.1.2 9.21E-05 None None None None N None 0 9.17551E-04 0 0 0 None 0 0 0 0 0
A/T 2192 Ig-11 19 rs774574739 0.2889 -1.516 0.905 N 0.69 0.217 0.132336055621 gnomAD-4.0.0 2.43371E-05 None None None None N None 0 3.22056E-04 None 0 0 None 0 0 0 0 0
G/A 2284 Ig-12 18 rs751111175 0.1218 -0.492 0.604 N 0.516 0.247 0.0666544352282 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 1.63506E-04
G/A 2284 Ig-12 18 rs751111175 0.1218 -0.492 0.604 N 0.516 0.247 0.0666544352282 gnomAD-4.0.0 3.42106E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49682E-06 0 0
V/F 2373 Ig-13 18 rs759496021 0.5643 -1.579 0.995 D 0.789 0.772 0.922070583027 gnomAD-2.1.1 1.77E-05 None None None None N None 4.01E-05 8.47E-05 None 0 0 None 0 None 0 7.76E-06 0
V/F 2373 Ig-13 18 rs759496021 0.5643 -1.579 0.995 D 0.789 0.772 0.922070583027 gnomAD-3.1.2 3.29E-05 None None None None N None 0 2.61814E-04 0 0 0 None 0 0 1.47E-05 0 0
V/F 2373 Ig-13 18 rs759496021 0.5643 -1.579 0.995 D 0.789 0.772 0.922070583027 gnomAD-4.0.0 1.42508E-05 None None None None N None 1.33479E-05 1.5001E-04 None 0 0 None 0 0 8.47468E-06 0 4.80154E-05
V/I 2373 Ig-13 18 None 0.108 None 0.78 D 0.601 0.441 0.670434146419 gnomAD-4.0.0 6.84097E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99311E-07 0 0
V/L 2373 Ig-13 18 None 0.3803 None 0.78 D 0.565 0.527 0.625611624611 gnomAD-4.0.0 6.84097E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
A/P 2462 Ig-14 18 None 0.9863 None 1.0 D 0.853 0.495 0.33835085245 gnomAD-4.0.0 1.36822E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99321E-07 1.15937E-05 0
A/T 2462 Ig-14 18 None 0.3285 None 0.996 N 0.624 0.307 0.212008924253 gnomAD-4.0.0 6.84112E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99321E-07 0 0
A/V 2462 Ig-14 18 None 0.3438 None 0.884 N 0.358 0.288 0.273503213844 gnomAD-4.0.0 1.59074E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02206E-05
V/M 2550 Ig-15 18 None 0.3098 None 0.942 D 0.677 0.296 0.456830177556 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
A/V 2637 Ig-16 17 None 0.2152 None 1.0 N 0.615 0.424 0.305086939656 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
A/T 2724 Ig-17 18 rs1346689247 0.4649 -1.258 1.0 D 0.679 0.706 0.721935125968 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
A/T 2724 Ig-17 18 rs1346689247 0.4649 -1.258 1.0 D 0.679 0.706 0.721935125968 gnomAD-4.0.0 1.36825E-06 None None None None N None 0 0 None 0 0 None 1.87547E-05 0 8.99297E-07 0 0
V/I 2812 Ig-18 18 None 0.1302 None 0.78 N 0.613 0.195 0.402614778071 gnomAD-4.0.0 1.36812E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
V/L 2812 Ig-18 18 rs146636599 0.6139 -0.254 0.78 N 0.597 0.16 None gnomAD-2.1.1 9.56E-05 None None None None N None 4.00609E-04 0 None 0 7.02247E-04 None 6.53E-05 None 0 0 1.38735E-04
V/L 2812 Ig-18 18 rs146636599 0.6139 -0.254 0.78 N 0.597 0.16 None gnomAD-3.1.2 1.44575E-04 None None None None N None 3.86156E-04 0 0 0 5.77812E-04 None 0 0 0 2.06954E-04 9.56023E-04
V/L 2812 Ig-18 18 rs146636599 0.6139 -0.254 0.78 N 0.597 0.16 None gnomAD-4.0.0 4.39862E-05 None None None None N None 2.79866E-04 0 None 0 6.01685E-04 None 0 0 3.38979E-06 7.68504E-05 1.91975E-04
A/S 2899 Ig-19 18 rs1561217531 0.348 None 1.0 D 0.599 0.565 0.530109961917 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
A/S 2899 Ig-19 18 rs1561217531 0.348 None 1.0 D 0.599 0.565 0.530109961917 gnomAD-4.0.0 1.59053E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85652E-06 0 0
I/T 2986 Ig-20 18 rs561206261 0.9174 -2.726 0.645 N 0.741 0.281 0.476832112026 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
I/T 2986 Ig-20 18 rs561206261 0.9174 -2.726 0.645 N 0.741 0.281 0.476832112026 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 0 1.47E-05 0 0
I/T 2986 Ig-20 18 rs561206261 0.9174 -2.726 0.645 N 0.741 0.281 0.476832112026 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
I/T 2986 Ig-20 18 rs561206261 0.9174 -2.726 0.645 N 0.741 0.281 0.476832112026 gnomAD-4.0.0 3.09773E-06 None None None None N None 0 1.66622E-05 None 0 0 None 0 0 3.38985E-06 0 0
I/V 2986 Ig-20 18 None 0.1035 None 0.002 N 0.224 0.081 0.209622950755 gnomAD-4.0.0 1.59074E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
A/D 3164 Ig-22 18 None 0.9798 None 0.998 N 0.853 0.458 0.335164054921 gnomAD-4.0.0 1.20056E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31274E-06 0 0
A/T 3256 Ig-23 18 rs1322989995 0.3218 -1.198 1.0 D 0.723 0.548 0.360565625551 gnomAD-2.1.1 3.99E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
A/T 3256 Ig-23 18 rs1322989995 0.3218 -1.198 1.0 D 0.723 0.548 0.360565625551 gnomAD-4.0.0 1.59087E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
A/G 3362 Ig-24 18 rs2089943424 0.3456 None 0.977 D 0.61 0.64 0.503374072614 gnomAD-4.0.0 1.5906E-06 None None None None N None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
A/P 3362 Ig-24 18 None 0.9661 None 0.997 D 0.848 0.704 0.584274139494 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 3482 Ig-25 18 rs1553970119 0.16 None None None None 0.237 None gnomAD-4.0.0 2.73693E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59809E-06 0 0
A/P 3677 Ig-26 18 None 0.9442 None None None None 0.242 None gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99463E-07 0 0
A/T 3677 Ig-26 18 rs1205546695 0.2263 None None None None 0.103 None gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99463E-07 0 0
A/P 3955 Ig-28 18 None 0.9541 None 0.999 D 0.783 0.428 None gnomAD-4.0.0 1.59107E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02389E-05
A/S 3955 Ig-28 18 rs1352554984 0.2436 -1.391 0.989 D 0.58 0.352 None gnomAD-2.1.1 7.14E-06 None None None None I None 0 2.83E-05 None 0 0 None 0 None 0 0 1.40292E-04
A/S 3955 Ig-28 18 rs1352554984 0.2436 -1.391 0.989 D 0.58 0.352 None gnomAD-4.0.0 3.18215E-06 None None None None I None 0 4.57247E-05 None 0 0 None 0 0 0 0 0
V/I 4623 Ig-29 18 None 0.0719 None None N 0.253 0.092 None gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 2.77485E-05 None 0 0 0 0 0
A/D 4717 Ig-30 18 None 0.9955 None 0.991 D 0.807 0.425 0.529361283073 gnomAD-4.0.0 6.84348E-07 None None None None I None 0 0 None 0 0 None 1.87378E-05 0 0 0 0
A/V 4717 Ig-30 18 None 0.5395 None 0.322 N 0.335 0.149 0.228597637076 gnomAD-4.0.0 6.84348E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99543E-07 0 0
A/D 4812 Ig-31 18 None 0.8915 None 0.864 D 0.787 0.412 0.449860987313 gnomAD-4.0.0 1.59375E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86356E-06 0 0
A/V 4812 Ig-31 18 None 0.177 None 0.006 N 0.303 0.146 0.184867976434 gnomAD-4.0.0 1.59375E-06 None None None None I None 0 0 None 4.77509E-05 0 None 0 0 0 0 0
V/D 4905 Ig-32 18 None 0.8365 None 0.484 D 0.753 0.52 0.6731056941 gnomAD-4.0.0 7.20193E-06 None None None None N None 0 0 None 0 0 None 0 0 7.87501E-06 0 0
V/I 4905 Ig-32 18 rs774495507 0.0617 -0.633 None N 0.153 0.074 0.15556083564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
A/T 5092 Ig-34 18 rs765723566 0.1477 -1.108 0.211 N 0.387 0.359 0.331619326243 gnomAD-2.1.1 2.08E-05 None None None None N None 0 0 None 0 0 None 1.7534E-04 None 0 0 0
A/T 5092 Ig-34 18 rs765723566 0.1477 -1.108 0.211 N 0.387 0.359 0.331619326243 gnomAD-4.0.0 1.29085E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.17151E-04 0
A/V 5092 Ig-34 18 None 0.1593 None 0.211 N 0.389 0.292 0.411531665326 gnomAD-4.0.0 1.61129E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89675E-06 0 0
V/A 5185 Ig-35 18 None 0.1699 None 0.999 N 0.549 0.307 0.516884031612 gnomAD-4.0.0 6.84303E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99598E-07 0 0
V/D 5185 Ig-35 18 None 0.8857 None 1.0 D 0.868 0.613 0.864880158096 gnomAD-4.0.0 6.84303E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99598E-07 0 0
V/I 5185 Ig-35 18 rs370535651 0.0824 -0.385 0.999 N 0.507 0.306 None gnomAD-2.1.1 1.037E-04 None None None None N None 5.37323E-04 8.5E-05 None 9.69E-05 3.59159E-04 None 3.27E-05 None 0 2.35E-05 1.40964E-04
V/I 5185 Ig-35 18 rs370535651 0.0824 -0.385 0.999 N 0.507 0.306 None gnomAD-3.1.2 1.44649E-04 None None None None N None 3.86212E-04 6.55E-05 0 0 0 None 0 0 7.35E-05 0 0
V/I 5185 Ig-35 18 rs370535651 0.0824 -0.385 0.999 N 0.507 0.306 None gnomAD-4.0.0 4.0291E-05 None None None None N None 3.4713E-04 8.33861E-05 None 0 2.0066E-04 None 0 1.64582E-04 1.4413E-05 2.19688E-05 8.00769E-05
A/T 5278 Ig-36 18 rs754692422 0.1754 -0.642 1.0 N 0.751 0.298 None gnomAD-2.1.1 4.03E-05 None None None None N None 0 1.45096E-04 None 0 0 None 9.81E-05 None 0 1.78E-05 0
A/T 5278 Ig-36 18 rs754692422 0.1754 -0.642 1.0 N 0.751 0.298 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
A/T 5278 Ig-36 18 rs754692422 0.1754 -0.642 1.0 N 0.751 0.298 None gnomAD-4.0.0 1.73522E-05 None None None None N None 2.66973E-05 1.16678E-04 None 0 2.22866E-05 None 0 0 8.47642E-06 8.78426E-05 0
C/R 5374 Ig-37 18 rs2080832566 0.6683 None 0.863 N 0.746 0.291 0.687224575613 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/Y 5374 Ig-37 18 rs375577529 0.4128 -1.214 0.975 N 0.731 0.28 None gnomAD-2.1.1 8.61E-05 None None None None N None 0 1.13695E-04 None 0 0 None 3.29E-05 None 0 1.49015E-04 0
C/Y 5374 Ig-37 18 rs375577529 0.4128 -1.214 0.975 N 0.731 0.28 None gnomAD-3.1.2 9.86E-05 None None None None N None 2.41E-05 1.3101E-04 0 0 0 None 0 0 1.61717E-04 0 4.78469E-04
C/Y 5374 Ig-37 18 rs375577529 0.4128 -1.214 0.975 N 0.731 0.28 None gnomAD-4.0.0 1.19064E-04 None None None None N None 1.33508E-05 1.00174E-04 None 0 0 None 0 0 1.50098E-04 1.09972E-05 1.12158E-04
V/F 5467 Ig-38 18 None 0.173 None 0.942 N 0.811 0.286 0.720981639776 gnomAD-4.0.0 1.59912E-06 None None None None N None 5.69411E-05 0 None 0 0 None 0 0 0 0 0
T/I 5561 Ig-39 19 rs1434244184 0.1004 None 0.166 N 0.519 0.144 0.168933306366 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 5561 Ig-39 19 rs1434244184 0.1004 None 0.166 N 0.519 0.144 0.168933306366 gnomAD-4.0.0 6.57324E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47046E-05 0 0
T/N 5561 Ig-39 19 None 0.133 None 0.491 N 0.586 0.214 0.209622950755 gnomAD-4.0.0 1.59223E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86007E-06 0 0
V/A 5654 Ig-40 18 None 0.2688 None 0.219 N 0.271 0.167 0.395595088485 gnomAD-4.0.0 1.59161E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85884E-06 0 0
V/G 5654 Ig-40 18 rs763581306 0.5121 -2.867 0.98 N 0.747 0.314 0.801125762009 gnomAD-2.1.1 4.03E-05 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-05 0
V/G 5654 Ig-40 18 rs763581306 0.5121 -2.867 0.98 N 0.747 0.314 0.801125762009 gnomAD-4.0.0 3.02406E-05 None None None None N None 0 0 None 0 0 None 0 0 4.57415E-05 0 9.07331E-05
A/T 5747 Ig-41 18 None 0.121 None 0.722 N 0.611 0.159 0.195762928549 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
A/D 5840 Ig-42 18 rs769399979 0.9859 -1.321 1.0 N 0.877 0.547 0.555712064712 gnomAD-2.1.1 3.62E-05 None None None None N None 0 0 None 0 5.01058E-04 None 0 None 0 0 0
A/D 5840 Ig-42 18 rs769399979 0.9859 -1.321 1.0 N 0.877 0.547 0.555712064712 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93349E-04 None 0 0 0 0 0
A/D 5840 Ig-42 18 rs769399979 0.9859 -1.321 1.0 N 0.877 0.547 0.555712064712 gnomAD-4.0.0 6.19761E-06 None None None None N None 0 0 None 0 2.00606E-04 None 0 0 0 0 1.60118E-05
I/S 5936 Ig-43 18 rs1365679296 0.4349 -2.522 0.27 N 0.535 0.457 0.619501705969 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 6.55E-05 None 0 0 0
I/S 5936 Ig-43 18 rs1365679296 0.4349 -2.522 0.27 N 0.535 0.457 0.619501705969 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
I/S 5936 Ig-43 18 rs1365679296 0.4349 -2.522 0.27 N 0.535 0.457 0.619501705969 gnomAD-4.0.0 1.23973E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.19703E-05 0
I/T 5936 Ig-43 18 rs1365679296 0.1433 -2.095 0.01 N 0.366 0.32 0.38225645794 gnomAD-2.1.1 6.37E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.29618E-04 0
I/T 5936 Ig-43 18 rs1365679296 0.1433 -2.095 0.01 N 0.366 0.32 0.38225645794 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 5936 Ig-43 18 rs1365679296 0.1433 -2.095 0.01 N 0.366 0.32 0.38225645794 gnomAD-4.0.0 1.8596E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54343E-06 0 0
I/V 5936 Ig-43 18 rs72648945 0.0737 -0.838 0.001 N 0.157 0.078 None gnomAD-2.1.1 9.71E-05 None None None None N None 8.29E-05 0 None 0 0 None 0 None 0 1.82271E-04 2.82725E-04
I/V 5936 Ig-43 18 rs72648945 0.0737 -0.838 0.001 N 0.157 0.078 None gnomAD-3.1.2 9.2E-05 None None None None N None 4.83E-05 6.55E-05 0 0 0 None 0 0 1.61689E-04 0 0
I/V 5936 Ig-43 18 rs72648945 0.0737 -0.838 0.001 N 0.157 0.078 None gnomAD-4.0.0 1.17777E-04 None None None None N None 5.34074E-05 3.33622E-05 None 0 0 None 0 3.29272E-04 1.44976E-04 0 1.76158E-04
V/G 6029 Ig-44 18 rs770360579 0.4783 -2.899 1.0 D 0.853 0.633 0.878771411214 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 5.75E-05 None 0 None 0 0 0
V/G 6029 Ig-44 18 rs770360579 0.4783 -2.899 1.0 D 0.853 0.633 0.878771411214 gnomAD-4.0.0 1.59723E-06 None None None None N None 0 0 None 0 2.79236E-05 None 0 0 0 0 0
V/I 6029 Ig-44 18 rs1274174149 0.0878 None 0.997 N 0.521 0.246 0.392547445146 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 6029 Ig-44 18 rs1274174149 0.0878 None 0.997 N 0.521 0.246 0.392547445146 gnomAD-4.0.0 6.57635E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47037E-05 0 0
V/L 6029 Ig-44 18 None 0.2897 None 0.997 N 0.573 0.301 0.31077124679 gnomAD-4.0.0 6.85255E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00335E-07 0 0
V/M 6216 Ig-46 18 rs369242073 0.1429 -0.734 0.999 N 0.665 0.273 None gnomAD-2.1.1 8.05E-06 None None None None N None 6.47E-05 0 None 0 0 None 3.27E-05 None 0 0 0
V/M 6216 Ig-46 18 rs369242073 0.1429 -0.734 0.999 N 0.665 0.273 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
V/M 6216 Ig-46 18 rs369242073 0.1429 -0.734 0.999 N 0.665 0.273 None gnomAD-4.0.0 1.54952E-05 None None None None N None 6.67682E-05 0 None 0 0 None 0 0 1.18681E-05 2.19621E-05 6.40533E-05
A/S 6309 Ig-47 18 None 0.2072 None 0.201 N 0.643 0.326 0.148003135375 gnomAD-4.0.0 1.60346E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87523E-06 0 0
M/T 6402 Ig-48 18 rs1268309891 0.2195 None 0.001 N 0.359 0.154 0.31291088546 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 6402 Ig-48 18 rs1268309891 0.2195 None 0.001 N 0.359 0.154 0.31291088546 gnomAD-4.0.0 6.57117E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47037E-05 0 0
M/V 6402 Ig-48 18 rs72648954 0.0467 -0.482 None N 0.125 0.101 None gnomAD-2.1.1 5.29019E-03 None None None None N None 5.12036E-02 2.95052E-03 None 4.8459E-03 0 None 1.31027E-04 None 0 4.61818E-04 3.38505E-03
M/V 6402 Ig-48 18 rs72648954 0.0467 -0.482 None N 0.125 0.101 None gnomAD-3.1.2 1.52917E-02 None None None None N None 5.17441E-02 6.61688E-03 0 6.33641E-03 0 None 0 9.49367E-03 3.38126E-04 2.06954E-04 1.52964E-02
M/V 6402 Ig-48 18 rs72648954 0.0467 -0.482 None N 0.125 0.101 None 1000 genomes 1.4976E-02 None None None None N None 5.14E-02 8.6E-03 None None 0 1E-03 None None None 0 None
M/V 6402 Ig-48 18 rs72648954 0.0467 -0.482 None N 0.125 0.101 None gnomAD-4.0.0 3.12341E-03 None None None None N None 5.11521E-02 4.35406E-03 None 5.9858E-03 0 None 0 3.47567E-03 3.53203E-04 1.31865E-04 4.97018E-03
I/T 6498 Ig-49 18 None 0.2756 None 0.896 N 0.659 0.265 0.574366754605 gnomAD-4.0.0 4.79111E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72711E-06 0 3.03343E-05
V/G 6591 Ig-50 18 rs2079619288 0.5815 None 0.997 N 0.757 0.487 0.795264024752 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
V/G 6591 Ig-50 18 rs2079619288 0.5815 None 0.997 N 0.757 0.487 0.795264024752 gnomAD-4.0.0 2.56654E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.69092E-05 0
A/T 6871 Ig-53 18 rs745807060 0.1128 -1.034 0.183 N 0.537 0.131 0.119812018005 gnomAD-2.1.1 4.07E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 0
A/T 6871 Ig-53 18 rs745807060 0.1128 -1.034 0.183 N 0.537 0.131 0.119812018005 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/T 6871 Ig-53 18 rs745807060 0.1128 -1.034 0.183 N 0.537 0.131 0.119812018005 gnomAD-4.0.0 2.57169E-06 None None None None N None 3.39029E-05 0 None 0 0 None 0 0 0 0 0
C/R 6965 Ig-54 18 None 0.8546 None 0.988 N 0.737 0.32 0.705616693011 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
C/Y 6965 Ig-54 18 None 0.5796 None 0.996 N 0.719 0.282 0.571967413633 gnomAD-4.0.0 1.59492E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86633E-06 0 0
V/I 7154 Ig-56 18 None 0.0813 None 0.001 N 0.214 0.06 0.270889551736 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/L 7247 Ig-57 18 None 0.1298 None None N 0.175 0.079 0.107399877778 gnomAD-4.0.0 6.84337E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99569E-07 0 0
I/T 7247 Ig-57 18 None 0.707 None 0.029 N 0.623 0.223 0.445614145163 gnomAD-4.0.0 4.77582E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57785E-06 0 0
I/V 7247 Ig-57 18 None 0.075 None None N 0.175 0.07 0.178374595973 gnomAD-4.0.0 6.84337E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99569E-07 0 0
V/D 7340 Ig-58 18 None 0.4225 None 0.642 N 0.711 0.28 0.69243939542 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 7340 Ig-58 18 rs566468573 0.0744 -0.107 0.425 N 0.576 0.105 0.259761712551 gnomAD-2.1.1 1.09162E-04 None None None None I None 0 0 None 0 5.62E-05 None 6.89429E-04 None 0 2.68E-05 3.3456E-04
V/I 7340 Ig-58 18 rs566468573 0.0744 -0.107 0.425 N 0.576 0.105 0.259761712551 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07039E-04 0
V/I 7340 Ig-58 18 rs566468573 0.0744 -0.107 0.425 N 0.576 0.105 0.259761712551 gnomAD-4.0.0 5.27016E-05 None None None None I None 0 0 None 0 0 None 0 0 1.18703E-05 6.81438E-04 1.44249E-04
V/A 7436 Ig-59 18 rs760391619 0.2719 -1.539 0.323 N 0.34 0.229 0.468168183122 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.30804E-04 None 0 0 0
V/A 7436 Ig-59 18 rs760391619 0.2719 -1.539 0.323 N 0.34 0.229 0.468168183122 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
V/A 7436 Ig-59 18 rs760391619 0.2719 -1.539 0.323 N 0.34 0.229 0.468168183122 gnomAD-4.0.0 6.19826E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.09832E-04 0
V/D 7436 Ig-59 18 rs760391619 0.9459 -1.459 0.998 D 0.821 0.773 0.918728754926 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
V/D 7436 Ig-59 18 rs760391619 0.9459 -1.459 0.998 D 0.821 0.773 0.918728754926 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/D 7436 Ig-59 18 rs760391619 0.9459 -1.459 0.998 D 0.821 0.773 0.918728754926 gnomAD-4.0.0 3.71896E-06 None None None None N None 0 0 None 0 0 None 0 0 5.0867E-06 0 0
I/L 7626 Ig-61 19 rs1560677297 0.1159 None None N 0.185 0.098 0.207176502487 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
I/L 7626 Ig-61 19 rs1560677297 0.1159 None None N 0.185 0.098 0.207176502487 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/L 7626 Ig-61 19 rs1560677297 0.1159 None None N 0.185 0.098 0.207176502487 gnomAD-4.0.0 6.57065E-06 None None None None N None 0 6.54965E-05 None 0 0 None 0 0 0 0 0
I/V 7626 Ig-61 19 None 0.0717 None None N 0.158 0.07 0.19670166235 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
F/L 7906 Ig-64 18 rs753446112 0.8534 -1.133 0.002 N 0.185 0.201 0.0920862733494 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 1.11421E-04 None 0 None 0 0 0
F/L 7906 Ig-64 18 rs753446112 0.8534 -1.133 0.002 N 0.185 0.201 0.0920862733494 gnomAD-4.0.0 1.91094E-05 None None None None N None 0 0 None 0 3.32853E-04 None 0 0 0 0 0
V/A 8002 Ig-65 18 None 0.0782 None None N 0.132 0.074 0.149567049428 gnomAD-4.0.0 2.05267E-06 None None None None I None 0 0 None 0 2.51915E-05 None 0 0 1.799E-06 0 0
V/F 8002 Ig-65 18 rs1332361126 0.1668 -1.004 0.317 N 0.723 0.184 0.3691244813 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/F 8002 Ig-65 18 rs1332361126 0.1668 -1.004 0.317 N 0.723 0.184 0.3691244813 gnomAD-4.0.0 3.18264E-06 None None None None I None 0 0 None 0 0 None 0 0 5.7171E-06 0 0
L/V 8095 Ig-66 18 rs2077909849 0.0528 None None N 0.185 0.066 0.117506650769 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
L/V 8095 Ig-66 18 rs2077909849 0.0528 None None N 0.185 0.066 0.117506650769 gnomAD-4.0.0 6.5754E-06 None None None None N None 0 6.55136E-05 None 0 0 None 0 0 0 0 0
I/M 8188 Ig-67 18 rs563728001 0.1452 -0.589 0.999 N 0.593 0.281 0.28297238246 gnomAD-2.1.1 1.21E-05 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 8.92E-06 0
I/M 8188 Ig-67 18 rs563728001 0.1452 -0.589 0.999 N 0.593 0.281 0.28297238246 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/M 8188 Ig-67 18 rs563728001 0.1452 -0.589 0.999 N 0.593 0.281 0.28297238246 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
I/M 8188 Ig-67 18 rs563728001 0.1452 -0.589 0.999 N 0.593 0.281 0.28297238246 gnomAD-4.0.0 1.36333E-05 None None None None I None 0 1.66633E-05 None 0 0 None 0 0 1.78012E-05 0 0
I/T 8188 Ig-67 18 rs1184649078 0.5552 -1.519 0.98 N 0.609 0.264 0.498065138572 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/T 8188 Ig-67 18 rs1184649078 0.5552 -1.519 0.98 N 0.609 0.264 0.498065138572 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 8188 Ig-67 18 rs1184649078 0.5552 -1.519 0.98 N 0.609 0.264 0.498065138572 gnomAD-4.0.0 3.09872E-06 None None None None I None 2.66937E-05 0 None 0 2.22896E-05 None 0 0 0 1.09813E-05 1.60133E-05
A/E 8281 Ig-68 18 rs1474165122 0.5176 -1.112 0.055 D 0.689 0.374 0.186928172975 gnomAD-2.1.1 8.22E-06 None None None None I None 0 0 None 0 0 None 6.55E-05 None 0 0 0
A/E 8281 Ig-68 18 rs1474165122 0.5176 -1.112 0.055 D 0.689 0.374 0.186928172975 gnomAD-4.0.0 4.83065E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.30108E-05 0
A/T 8281 Ig-68 18 rs2077783832 0.076 None None N 0.183 0.211 0.0401082797425 gnomAD-4.0.0 1.61075E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86054E-06 0 0
V/A 8377 Ig-69 18 None 0.2812 None 0.709 N 0.262 0.144 0.273070737957 gnomAD-4.0.0 1.36895E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79931E-06 0 0
G/S 8473 Ig-70 18 rs769092741 0.1377 -0.73 0.713 N 0.633 0.179 0.101711395817 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
G/S 8473 Ig-70 18 rs769092741 0.1377 -0.73 0.713 N 0.633 0.179 0.101711395817 gnomAD-4.0.0 7.95902E-06 None None None None N None 0 0 None 0 0 None 0 0 1.42979E-05 0 0
T/A 8567 Ig-71 19 rs777832511 0.0726 -0.846 0.002 N 0.323 0.088 0.0806252709748 gnomAD-2.1.1 4.34E-06 None None None None N None 7.09E-05 0 None 0 0 None 0 None 0 0 0
T/A 8567 Ig-71 19 rs777832511 0.0726 -0.846 0.002 N 0.323 0.088 0.0806252709748 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
T/A 8567 Ig-71 19 rs777832511 0.0726 -0.846 0.002 N 0.323 0.088 0.0806252709748 gnomAD-4.0.0 6.2339E-06 None None None None N None 1.20334E-04 0 None 0 0 None 0 0 0 0 1.61005E-05
T/K 8567 Ig-71 19 rs867794054 0.4683 None 0.864 N 0.751 0.192 0.230578612272 gnomAD-4.0.0 1.61538E-06 None None None None N None 0 0 None 0 0 None 0 2.41663E-04 0 0 0
T/P 8567 Ig-71 19 rs777832511 0.4553 -0.192 0.906 N 0.809 0.237 0.239305524855 gnomAD-2.1.1 4.34E-06 None None None None N None 0 0 None 0 0 None 3.49E-05 None 0 0 0
T/P 8567 Ig-71 19 rs777832511 0.4553 -0.192 0.906 N 0.809 0.237 0.239305524855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
T/P 8567 Ig-71 19 rs777832511 0.4553 -0.192 0.906 N 0.809 0.237 0.239305524855 gnomAD-4.0.0 6.57263E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06868E-04 0
V/A 8660 Ig-72 18 None 0.237 None 0.023 N 0.247 0.087 0.350746614512 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 3.66327E-05
V/I 8660 Ig-72 18 rs141856116 0.076 -0.581 0.002 N 0.349 0.061 None gnomAD-2.1.1 1.49573E-03 None None None None N None 1.03348E-02 1.32986E-03 None 5.50938E-03 0 None 3.27E-05 None 0 4.45083E-04 9.83699E-04
V/I 8660 Ig-72 18 rs141856116 0.076 -0.581 0.002 N 0.349 0.061 None gnomAD-3.1.2 3.46405E-03 None None None None N None 1.07169E-02 2.16082E-03 0 6.33641E-03 0 None 0 3.16456E-03 3.08715E-04 0 2.86807E-03
V/I 8660 Ig-72 18 rs141856116 0.076 -0.581 0.002 N 0.349 0.061 None 1000 genomes 3.79393E-03 None None None None N None 1.13E-02 4.3E-03 None None 0 1E-03 None None None 0 None
V/I 8660 Ig-72 18 rs141856116 0.076 -0.581 0.002 N 0.349 0.061 None gnomAD-4.0.0 1.02997E-03 None None None None N None 1.08E-02 1.61656E-03 None 6.82571E-03 0 None 0 1.98413E-03 3.59419E-04 4.3929E-05 1.80858E-03
V/G 8753 Ig-73 18 rs867579263 0.1443 None 0.285 N 0.727 0.307 0.711079051923 gnomAD-4.0.0 5.4756E-06 None None None None I None 8.97022E-05 0 None 0 0 None 0 1.73611E-04 2.6989E-06 0 1.65733E-05
V/I 8753 Ig-73 18 rs373070956 0.0723 -0.328 None N 0.335 0.13 None gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
V/I 8753 Ig-73 18 rs373070956 0.0723 -0.328 None N 0.335 0.13 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 8753 Ig-73 18 rs373070956 0.0723 -0.328 None N 0.335 0.13 None gnomAD-4.0.0 6.57367E-06 None None None None I None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
C/G 8847 Ig-74 18 None 0.2099 None 0.92 N 0.663 0.287 0.514416127146 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/W 8847 Ig-74 18 None 0.6623 None 0.999 N 0.659 0.257 0.293502639404 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/Y 8847 Ig-74 18 None 0.41 None 0.996 N 0.727 0.339 0.493964856914 gnomAD-4.0.0 3.60098E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
V/D 8943 Ig-75 18 rs948198555 0.6527 -0.29 0.175 N 0.66 0.257 0.67065575343 gnomAD-2.1.1 4.64E-06 None None None None N None 0 3.29E-05 None 0 0 None 0 None 0 0 0
V/D 8943 Ig-75 18 rs948198555 0.6527 -0.29 0.175 N 0.66 0.257 0.67065575343 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 0 9.56938E-04
V/D 8943 Ig-75 18 rs948198555 0.6527 -0.29 0.175 N 0.66 0.257 0.67065575343 gnomAD-4.0.0 6.56678E-06 None None None None N None 0 3.58346E-05 None 0 0 None 0 0 0 0 8.6881E-05
V/I 8943 Ig-75 18 rs529187709 0.0704 -0.292 0.001 N 0.277 0.091 0.251639045875 gnomAD-2.1.1 1.17134E-04 None None None None N None 0 0 None 0 0 None 8.52799E-04 None 0 2.15E-05 0
V/I 8943 Ig-75 18 rs529187709 0.0704 -0.292 0.001 N 0.277 0.091 0.251639045875 gnomAD-3.1.2 4.6E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 1.24121E-03 0
V/I 8943 Ig-75 18 rs529187709 0.0704 -0.292 0.001 N 0.277 0.091 0.251639045875 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
V/I 8943 Ig-75 18 rs529187709 0.0704 -0.292 0.001 N 0.277 0.091 0.251639045875 gnomAD-4.0.0 6.71699E-05 None None None None N None 1.33772E-05 0 None 0 0 None 0 0 1.54047E-05 9.40979E-04 8.09245E-05
V/A 9036 Ig-76 18 None 0.3144 None 0.939 N 0.542 0.203 0.518697010188 gnomAD-4.0.0 1.59279E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86035E-06 0 0
V/L 9036 Ig-76 18 rs2076875576 0.2896 None 0.046 N 0.249 0.123 0.31077124679 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 9036 Ig-76 18 rs2076875576 0.2896 None 0.046 N 0.249 0.123 0.31077124679 gnomAD-4.0.0 6.57039E-06 None None None None N None 2.41231E-05 0 None 0 0 None 0 0 0 0 0
A/S 9222 Ig-78 18 None 0.2142 None 0.959 N 0.615 0.279 0.163833314356 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 9222 Ig-78 18 rs786205313 0.1206 -0.019 0.061 N 0.238 0.221 0.15556083564 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/V 9222 Ig-78 18 rs786205313 0.1206 -0.019 0.061 N 0.238 0.221 0.15556083564 gnomAD-4.0.0 7.95639E-06 None None None None I None 0 0 None 0 0 None 1.88239E-05 0 1.14336E-05 0 0
V/F 9318 Ig-79 18 rs368920200 0.4909 -1.094 0.968 None 0.752 0.243 None gnomAD-2.1.1 8.04E-06 None None None None N None 1.29216E-04 0 None 0 0 None 0 None 0 0 0
V/F 9318 Ig-79 18 rs368920200 0.4909 -1.094 0.968 None 0.752 0.243 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/F 9318 Ig-79 18 rs368920200 0.4909 -1.094 0.968 None 0.752 0.243 None gnomAD-4.0.0 2.02987E-06 None None None None N None 3.49406E-05 0 None 0 0 None 0 0 0 0 0
A/V 9414 Ig-80 18 None 0.133 None 0.046 None 0.275 0.153 0.16115917748 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
F/L 9511 Ig-81 19 None 0.8082 None 0.002 None 0.227 0.138 0.0986583533028 gnomAD-4.0.0 1.59145E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
V/L 9607 Ig-82 18 None 0.0937 None 0.001 None 0.149 0.064 0.119812018005 gnomAD-4.0.0 6.84195E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99462E-07 0 0
V/M 9607 Ig-82 18 rs375807609 0.1385 -0.471 0.095 None 0.237 0.027 None gnomAD-2.1.1 1.10543E-04 None None None None N None 1.65371E-04 8.49E-05 None 0 1.07505E-03 None 3.27E-05 None 4E-05 7.79E-06 0
V/M 9607 Ig-82 18 rs375807609 0.1385 -0.471 0.095 None 0.237 0.027 None gnomAD-3.1.2 5.26E-05 None None None None N None 4.83E-05 0 0 0 7.68935E-04 None 0 0 2.94E-05 0 0
V/M 9607 Ig-82 18 rs375807609 0.1385 -0.471 0.095 None 0.237 0.027 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
V/M 9607 Ig-82 18 rs375807609 0.1385 -0.471 0.095 None 0.237 0.027 None gnomAD-4.0.0 5.20488E-05 None None None None N None 6.66311E-05 9.999E-05 None 0 5.34688E-04 None 0 0 3.5599E-05 5.48992E-05 3.20102E-05
A/E 9715 Ig-83 18 None 0.9978 None 1.0 None 0.817 0.546 0.506494895843 gnomAD-4.0.0 1.37373E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80376E-06 0 0
A/G 9715 Ig-83 18 rs533172128 0.7237 -1.446 1.0 None 0.629 0.451 None gnomAD-2.1.1 4.06E-05 None None None None N None 0 0 None 0 0 None 0 None 0 8.03E-05 1.68407E-04
A/G 9715 Ig-83 18 rs533172128 0.7237 -1.446 1.0 None 0.629 0.451 None gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
A/G 9715 Ig-83 18 rs533172128 0.7237 -1.446 1.0 None 0.629 0.451 None gnomAD-4.0.0 2.86075E-05 None None None None N None 1.34055E-05 0 None 0 0 None 0 0 3.65401E-05 0 3.21585E-05
A/P 9715 Ig-83 18 rs1359943299 0.9961 -0.326 1.0 None 0.848 0.569 0.463157528383 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.38E-05 None 0 0 0
A/P 9715 Ig-83 18 rs1359943299 0.9961 -0.326 1.0 None 0.848 0.569 0.463157528383 gnomAD-4.0.0 1.60532E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45756E-05 0
A/T 9715 Ig-83 18 None 0.832 None 0.996 None 0.636 0.409 0.344483371355 gnomAD-4.0.0 1.60532E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88198E-06 0 0
A/V 9715 Ig-83 18 rs533172128 0.7563 0.297 0.977 None 0.363 0.295 0.329282125956 gnomAD-2.1.1 2.44E-05 None None None None N None 0 1.17751E-04 None 0 0 None 3.39E-05 None 0 8.92E-06 0
A/V 9715 Ig-83 18 rs533172128 0.7563 0.297 0.977 None 0.363 0.295 0.329282125956 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/V 9715 Ig-83 18 rs533172128 0.7563 0.297 0.977 None 0.363 0.295 0.329282125956 gnomAD-4.0.0 9.32852E-06 None None None None N None 1.34055E-05 1.01014E-04 None 0 0 None 0 0 3.39908E-06 4.45127E-05 0
A/V 9917 Ig-84 18 None 0.7518 None 0.117 None 0.309 0.253 0.26169431596 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
A/T 10095 Ig-86 18 rs201635835 0.9561 -1.402 1.0 None 0.754 0.285 None gnomAD-2.1.1 6.06E-05 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 1.1683E-04 1.40017E-04
A/T 10095 Ig-86 18 rs201635835 0.9561 -1.402 1.0 None 0.754 0.285 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 1.02905E-04 0 0
A/T 10095 Ig-86 18 rs201635835 0.9561 -1.402 1.0 None 0.754 0.285 None gnomAD-4.0.0 8.73615E-05 None None None None N None 0 4.99817E-05 None 0 0 None 0 0 1.12724E-04 0 8.00154E-05
A/T 13704 Ig-87 21 rs1259815299 0.6003 -1.357 1.0 N 0.761 0.303 0.345632371893 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 2.87853E-04 0 0
A/T 13704 Ig-87 21 rs1259815299 0.6003 -1.357 1.0 N 0.761 0.303 0.345632371893 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 1.88359E-04 0 0 0 0
A/T 13704 Ig-87 21 rs1259815299 0.6003 -1.357 1.0 N 0.761 0.303 0.345632371893 gnomAD-4.0.0 3.71907E-06 None None None None N None 0 0 None 0 0 None 7.81128E-05 0 8.47746E-07 0 0
L/S 13798 Ig-88 19 rs779304267 0.9534 -2.978 0.876 N 0.697 0.266 0.438383285633 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
L/S 13798 Ig-88 19 rs779304267 0.9534 -2.978 0.876 N 0.697 0.266 0.438383285633 gnomAD-4.0.0 1.59522E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86467E-06 0 0
A/S 13982 Ig-90 18 rs865925187 0.7385 None 0.999 D 0.575 0.359 0.17258766438 gnomAD-4.0.0 2.05324E-06 None None None None N None 0 0 None 0 0 None 0 5.21014E-04 0 0 0
A/T 13982 Ig-90 18 rs865925187 0.8272 None 1.0 D 0.751 0.382 0.193865811164 gnomAD-4.0.0 6.84412E-07 None None None None N None 2.99043E-05 0 None 0 0 None 0 0 0 0 0
A/V 13982 Ig-90 18 rs1344724361 0.7166 None 0.999 N 0.639 0.395 0.306053231325 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/V 13982 Ig-90 18 rs1344724361 0.7166 None 0.999 N 0.639 0.395 0.306053231325 gnomAD-4.0.0 6.57825E-06 None None None None N None 0 6.5548E-05 None 0 0 None 0 0 0 0 0
A/P 14071 Ig-91 18 None 0.9921 None 1.0 D 0.856 0.532 0.447012531364 gnomAD-4.0.0 2.05319E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69896E-06 0 0
A/T 14071 Ig-91 18 rs2154227681 0.7653 None 0.999 D 0.749 0.431 0.340753184043 gnomAD-4.0.0 6.84396E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99654E-07 0 0
A/T 14336 Ig-94 18 rs2060026775 0.5097 None 0.071 D 0.266 0.347 0.221734844693 gnomAD-4.0.0 6.36914E-06 None None None None N None 0 0 None 0 1.11111E-04 None 0 0 0 0 0
A/V 14336 Ig-94 18 rs749230107 0.427 -0.084 0.841 N 0.51 0.33 0.30921473904 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 2.79486E-04 None 0 None 0 0 0
A/V 14336 Ig-94 18 rs749230107 0.427 -0.084 0.841 N 0.51 0.33 0.30921473904 gnomAD-4.0.0 1.75153E-05 None None None None N None 0 0 None 0 3.05539E-04 None 0 0 0 0 0
A/S 14425 Ig-95 18 None 0.4531 None 0.996 D 0.55 0.537 0.550418665841 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85992E-06 0 0
A/T 14425 Ig-95 18 None 0.4666 None 0.999 D 0.73 0.532 0.558070701127 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85992E-06 0 0
A/P 14514 Ig-96 18 None 0.9715 None 1.0 D 0.861 0.598 0.797850590631 gnomAD-4.0.0 6.883E-07 None None None None N None 0 0 None 0 0 None 0 0 9.03023E-07 0 0
A/T 14514 Ig-96 18 rs1277313297 0.2578 None 1.0 D 0.705 0.595 0.751342362238 gnomAD-4.0.0 6.88301E-07 None None None None N None 0 2.29064E-05 None 0 0 None 0 0 0 0 0
V/I 14603 Ig-97 18 rs2154220273 0.104 None 0.987 N 0.515 0.2 0.356072328145 gnomAD-4.0.0 3.18894E-06 None None None None N None 0 0 None 0 5.58005E-05 None 0 0 0 0 0
A/E 14870 Ig-100 18 None 0.9659 None 0.994 D 0.833 0.37 0.324161360171 gnomAD-4.0.0 2.40067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
A/T 14959 Ig-101 18 None 0.5312 None 0.999 D 0.757 0.316 0.301122078929 gnomAD-4.0.0 6.86992E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01671E-07 0 0
A/V 14959 Ig-101 18 None 0.4099 None 0.999 N 0.683 0.348 0.275215494804 gnomAD-4.0.0 1.60627E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45904E-05 0
I/K 15048 Ig-102 18 rs727505261 0.9348 -2.306 0.484 D 0.733 0.634 0.831925844807 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
I/K 15048 Ig-102 18 rs727505261 0.9348 -2.306 0.484 D 0.733 0.634 0.831925844807 gnomAD-4.0.0 6.84814E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99954E-07 0 0
I/T 15048 Ig-102 18 rs727505261 0.7085 -2.996 0.062 D 0.641 0.486 0.67026131262 gnomAD-2.1.1 8.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 0
I/T 15048 Ig-102 18 rs727505261 0.7085 -2.996 0.062 D 0.641 0.486 0.67026131262 gnomAD-3.1.2 1.98E-05 None None None None N None 0 0 0 0 0 None 0 0 4.42E-05 0 0
I/T 15048 Ig-102 18 rs727505261 0.7085 -2.996 0.062 D 0.641 0.486 0.67026131262 gnomAD-4.0.0 1.17857E-05 None None None None N None 0 0 None 0 2.24155E-05 None 0 0 1.35702E-05 0 3.20718E-05
A/D 15137 Ig-103 18 rs1305459337 0.993 -2.052 1.0 D 0.84 0.486 0.651316673006 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
A/D 15137 Ig-103 18 rs1305459337 0.993 -2.052 1.0 D 0.84 0.486 0.651316673006 gnomAD-4.0.0 1.59519E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43526E-05 0
V/A 15225 Ig-104 18 rs1449233780 0.212 -2.17 0.001 N 0.201 0.079 0.199424873507 gnomAD-2.1.1 4.05E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
V/A 15225 Ig-104 18 rs1449233780 0.212 -2.17 0.001 N 0.201 0.079 0.199424873507 gnomAD-4.0.0 1.59415E-06 None None None None N None 5.67795E-05 0 None 0 0 None 0 0 0 0 0
V/F 15225 Ig-104 18 None 0.5392 None 0.655 N 0.725 0.213 0.677595378676 gnomAD-4.0.0 6.84749E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99883E-07 0 0
V/I 15225 Ig-104 18 rs757519339 0.11 -0.292 0.001 N 0.236 0.081 0.324986149311 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
V/I 15225 Ig-104 18 rs757519339 0.11 -0.292 0.001 N 0.236 0.081 0.324986149311 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 15225 Ig-104 18 rs757519339 0.11 -0.292 0.001 N 0.236 0.081 0.324986149311 gnomAD-4.0.0 1.24047E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69612E-06 0 0
A/D 15408 Ig-106 18 rs537697585 0.9963 -1.714 1.0 D 0.849 0.739 0.826406704241 gnomAD-2.1.1 4.68E-06 None None None None N None 0 3.33E-05 None 0 0 None 0 None 0 0 0
A/D 15408 Ig-106 18 rs537697585 0.9963 -1.714 1.0 D 0.849 0.739 0.826406704241 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
A/D 15408 Ig-106 18 rs537697585 0.9963 -1.714 1.0 D 0.849 0.739 0.826406704241 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
A/D 15408 Ig-106 18 rs537697585 0.9963 -1.714 1.0 D 0.849 0.739 0.826406704241 gnomAD-4.0.0 6.57756E-06 None None None None N None 0 6.5591E-05 None 0 0 None 0 0 0 0 0
A/S 15408 Ig-106 18 rs730880239 0.5366 None 1.0 D 0.581 0.672 0.670494219762 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
A/T 15408 Ig-106 18 rs730880239 0.6177 -1.436 1.0 D 0.707 0.609 None gnomAD-2.1.1 1.59578E-04 None None None None N None 0 1.29862E-04 None 0 5.34E-05 None 0 None 3.96336E-04 1.92375E-04 4.92287E-04
A/T 15408 Ig-106 18 rs730880239 0.6177 -1.436 1.0 D 0.707 0.609 None gnomAD-3.1.2 5.93E-05 None None None None N None 0 6.57E-05 0 0 0 None 1.88395E-04 0 8.84E-05 0 0
A/T 15408 Ig-106 18 rs730880239 0.6177 -1.436 1.0 D 0.707 0.609 None gnomAD-4.0.0 8.24287E-05 None None None None N None 0 9.11677E-05 None 0 2.25805E-05 None 5.4694E-04 0 7.26984E-05 0 8.2971E-05
A/V 15408 Ig-106 18 None 0.5799 None 1.0 D 0.607 0.491 0.636647316547 gnomAD-4.0.0 3.53649E-06 None None None None N None 0 0 None 0 0 None 0 0 4.59574E-06 0 0
V/A 15497 Ig-107 18 rs2057998545 0.3929 None 0.999 N 0.571 0.6 0.748464722647 gnomAD-4.0.0 3.18911E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86428E-06 1.43431E-05 0
V/F 15497 Ig-107 18 rs371299188 0.788 -1.353 1.0 D 0.869 0.484 0.90349967066 gnomAD-2.1.1 8.49E-05 None None None None N None 0 0 None 0 7.28536E-04 None 2.28998E-04 None 0 8.95E-06 0
V/F 15497 Ig-107 18 rs371299188 0.788 -1.353 1.0 D 0.869 0.484 0.90349967066 gnomAD-3.1.2 5.27E-05 None None None None N None 0 0 0 0 1.55642E-03 None 0 0 0 0 0
V/F 15497 Ig-107 18 rs371299188 0.788 -1.353 1.0 D 0.869 0.484 0.90349967066 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
V/F 15497 Ig-107 18 rs371299188 0.788 -1.353 1.0 D 0.869 0.484 0.90349967066 gnomAD-4.0.0 3.22538E-05 None None None None N None 0 0 None 0 4.69715E-04 None 0 0 8.48241E-07 2.30759E-04 1.44231E-04
I/N 15980 Ig-109 13 None 0.9684 None 0.989 N 0.719 0.437 0.70846858115 gnomAD-4.0.0 1.59336E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86267E-06 0 0
I/T 15980 Ig-109 13 rs1299741531 0.9326 -2.322 0.891 N 0.653 0.283 0.545432718849 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
I/T 15980 Ig-109 13 rs1299741531 0.9326 -2.322 0.891 N 0.653 0.283 0.545432718849 gnomAD-4.0.0 3.18672E-06 None None None None N None 0 4.57582E-05 None 0 0 None 0 0 0 0 0
I/V 15980 Ig-109 13 rs780634456 0.1063 -0.707 0.267 N 0.405 0.053 0.233785782151 gnomAD-2.1.1 6.05E-05 None None None None N None 0 0 None 0 0 None 3.92182E-04 None 0 1.79E-05 1.66279E-04
I/V 15980 Ig-109 13 rs780634456 0.1063 -0.707 0.267 N 0.405 0.053 0.233785782151 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.57E-05 0 0 0 None 0 0 2.95E-05 2.07383E-04 0
I/V 15980 Ig-109 13 rs780634456 0.1063 -0.707 0.267 N 0.405 0.053 0.233785782151 gnomAD-4.0.0 2.66651E-05 None None None None N None 0 1.66889E-05 None 0 0 None 0 4.94234E-04 1.18733E-05 2.52608E-04 3.20554E-05
I/T 16276 Ig-110 15 rs759916327 0.9387 -2.047 1.0 N 0.806 0.517 0.668420555392 gnomAD-2.1.1 3.24E-05 None None None None N None 0 2.91E-05 None 0 3.39597E-04 None 3.27E-05 None 0 0 0
I/T 16276 Ig-110 15 rs759916327 0.9387 -2.047 1.0 N 0.806 0.517 0.668420555392 gnomAD-4.0.0 1.91754E-05 None None None None N None 2.99437E-05 2.24175E-05 None 0 2.28172E-04 None 0 0 1.43999E-05 1.16031E-05 0
I/V 16276 Ig-110 15 None 0.1829 None 0.993 N 0.343 0.207 0.453772157364 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
L/P 17690 Ig-113 14 rs370469461 0.9883 -1.445 0.999 N 0.871 0.597 0.805114648059 gnomAD-2.1.1 8.08E-06 None None None None N None 6.49E-05 2.9E-05 None 0 0 None 0 None 0 0 0
L/P 17690 Ig-113 14 rs370469461 0.9883 -1.445 0.999 N 0.871 0.597 0.805114648059 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20691E-04 0 0 0 0 None 0 0 0 0 0
L/P 17690 Ig-113 14 rs370469461 0.9883 -1.445 0.999 N 0.871 0.597 0.805114648059 gnomAD-4.0.0 7.69387E-06 None None None None N None 8.46339E-05 1.69601E-05 None 0 0 None 0 0 0 0 0
I/V 18396 Ig-115 15 None 0.203 None None N 0.185 0.064 0.294918367191 gnomAD-4.0.0 1.59353E-06 None None None None I None 0 0 None 0 2.78272E-05 None 0 0 0 0 0
F/S 19404 Ig-118 14 None 0.9735 None 0.959 N 0.556 0.316 0.541239005379 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
L/R 19804 Ig-119 15 None 0.9703 None 0.97 N 0.741 0.536 0.649577115175 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/L 20494 Ig-121 16 None 0.2159 None 0.889 N 0.362 0.133 0.461323234107 gnomAD-4.0.0 6.97205E-07 None None None None N None 0 0 None 0 2.53691E-05 None 0 0 0 0 0
I/T 20494 Ig-121 16 rs374845737 0.966 -2.45 0.989 N 0.708 0.42 None gnomAD-2.1.1 2.21E-05 None None None None N None 3.28861E-04 0 None 0 0 None 0 None 0 0 0
I/T 20494 Ig-121 16 rs374845737 0.966 -2.45 0.989 N 0.708 0.42 None gnomAD-3.1.2 3.95E-05 None None None None N None 1.44851E-04 0 0 0 0 None 0 0 0 0 0
I/T 20494 Ig-121 16 rs374845737 0.966 -2.45 0.989 N 0.708 0.42 None gnomAD-4.0.0 1.58831E-05 None None None None N None 1.88343E-04 0 None 0 0 None 0 0 0 0 2.93496E-05
I/V 20494 Ig-121 16 None 0.1305 None 0.333 N 0.19 0.073 0.329282125956 gnomAD-4.0.0 1.39441E-06 None None None None N None 0 0 None 0 0 None 0 0 1.82057E-06 0 0
I/N 20787 Ig-122 19 None 0.9886 None 0.998 N 0.819 0.48 0.782853610656 gnomAD-4.0.0 6.84334E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99556E-07 0 0
I/T 20787 Ig-122 19 rs762932429 0.9645 -2.048 0.961 N 0.725 0.331 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/T 20787 Ig-122 19 rs762932429 0.9645 -2.048 0.961 N 0.725 0.331 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 20787 Ig-122 19 rs762932429 0.9645 -2.048 0.961 N 0.725 0.331 None gnomAD-4.0.0 1.36365E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61066E-05 0 4.80461E-05
I/V 20787 Ig-122 19 None 0.0954 None 0.122 N 0.213 0.079 0.257292322809 gnomAD-4.0.0 1.59199E-06 None None None None N None 0 0 None 0 2.77932E-05 None 0 0 0 0 0
I/V 21192 Ig-123 16 rs758357424 0.1499 -1.013 0.993 N 0.359 0.24 0.366277470483 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
I/V 21192 Ig-123 16 rs758357424 0.1499 -1.013 0.993 N 0.359 0.24 0.366277470483 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/V 21192 Ig-123 16 rs758357424 0.1499 -1.013 0.993 N 0.359 0.24 0.366277470483 gnomAD-4.0.0 1.97371E-05 None None None None I None 0 0 None 0 0 None 0 0 4.41462E-05 0 0
L/P 21484 Ig-124 16 None 0.9929 None 1.0 N 0.869 0.533 0.735635039567 gnomAD-4.0.0 1.59651E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86628E-06 0 0
L/V 21484 Ig-124 16 None 0.1998 None 0.992 N 0.556 0.278 0.341226946553 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 21881 Ig-125 16 rs2048158177 0.0968 None 0.025 N 0.206 0.128 0.326616659874 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 21881 Ig-125 16 rs2048158177 0.0968 None 0.025 N 0.206 0.128 0.326616659874 gnomAD-4.0.0 6.57756E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47115E-05 0 0
M/R 22279 Ig-126 15 rs758406122 0.9838 -1.123 0.773 N 0.732 0.441 0.564133873757 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 6.68449E-04
M/R 22279 Ig-126 15 rs758406122 0.9838 -1.123 0.773 N 0.732 0.441 0.564133873757 gnomAD-4.0.0 6.162E-06 None None None None N None 0 0 None 0 0 None 0 1.04239E-03 0 0 4.97529E-05
M/V 22279 Ig-126 15 rs780268398 0.3094 -1.596 0.015 N 0.435 0.233 0.303123707472 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 1.69186E-04 None 0 None 0 0 1.67112E-04
M/V 22279 Ig-126 15 rs780268398 0.3094 -1.596 0.015 N 0.435 0.233 0.303123707472 gnomAD-4.0.0 4.10802E-06 None None None None N None 0 0 None 0 1.26653E-04 None 0 0 0 0 1.65848E-05
I/T 22964 Ig-128 15 None 0.7076 None 0.892 N 0.546 0.316 0.518858945281 gnomAD-4.0.0 1.37371E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80449E-06 0 0
I/L 23362 Ig-129 18 rs372048460 0.2212 -0.787 0.002 N 0.259 0.163 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/L 23362 Ig-129 18 rs372048460 0.2212 -0.787 0.002 N 0.259 0.163 None gnomAD-4.0.0 5.47447E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19665E-06 0 0
I/T 23362 Ig-129 18 rs750943570 0.9637 -2.109 0.643 N 0.695 0.386 0.53837629882 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 23362 Ig-129 18 rs750943570 0.9637 -2.109 0.643 N 0.695 0.386 0.53837629882 gnomAD-4.0.0 2.05292E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99582E-07 2.31906E-05 0
I/N 23651 Ig-130 15 None 0.9521 None 0.998 N 0.799 0.57 0.6849472881 gnomAD-4.0.0 6.84658E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99777E-07 0 0
I/S 23651 Ig-130 15 rs149075285 0.9303 -2.445 0.994 N 0.768 0.51 None gnomAD-2.1.1 7.9867E-04 None None None None N None 8.10474E-03 5.12091E-04 None 0 0 None 0 None 0 5.51E-05 2.83366E-04
I/S 23651 Ig-130 15 rs149075285 0.9303 -2.445 0.994 N 0.768 0.51 None gnomAD-3.1.2 2.42092E-03 None None None None N None 8.28382E-03 8.51789E-04 0 0 0 None 0 0 5.88E-05 0 3.83142E-03
I/S 23651 Ig-130 15 rs149075285 0.9303 -2.445 0.994 N 0.768 0.51 None 1000 genomes 2.39617E-03 None None None None N None 9.1E-03 0 None None 0 0 None None None 0 None
I/S 23651 Ig-130 15 rs149075285 0.9303 -2.445 0.994 N 0.768 0.51 None gnomAD-4.0.0 4.54514E-04 None None None None N None 8.37534E-03 5.84151E-04 None 6.76178E-05 0 None 0 3.30251E-04 1.95022E-05 0 6.88816E-04
F/L 24047 Ig-131 19 rs1709172090 0.9355 None 0.999 N 0.551 0.476 0.20549828249 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/L 24047 Ig-131 19 rs1709172090 0.9355 None 0.999 N 0.551 0.476 0.20549828249 gnomAD-4.0.0 4.3391E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93416E-06 0 0
L/Q 24733 Ig-133 18 None 0.9545 None 0.999 N 0.889 0.482 0.811399548127 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/C 25129 Ig-134 19 None 0.649 None 1.0 N 0.843 0.568 0.597511309715 gnomAD-4.0.0 6.84285E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
F/L 25129 Ig-134 19 rs373411870 0.8693 -1.218 0.999 N 0.563 0.474 0.208000267992 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
F/L 25129 Ig-134 19 rs373411870 0.8693 -1.218 0.999 N 0.563 0.474 0.208000267992 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
F/L 25129 Ig-134 19 rs373411870 0.8693 -1.218 0.999 N 0.563 0.474 0.208000267992 gnomAD-4.0.0 1.59168E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8593E-06 0 0
F/Y 25129 Ig-134 19 None 0.55 None 0.999 N 0.551 0.393 0.355242300401 gnomAD-4.0.0 6.84285E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
L/F 25815 Ig-136 18 rs777970390 0.3292 -1.383 0.988 N 0.798 0.262 0.471700387322 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
L/F 25815 Ig-136 18 rs777970390 0.3292 -1.383 0.988 N 0.798 0.262 0.471700387322 gnomAD-4.0.0 2.05316E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69881E-06 0 0
L/W 25815 Ig-136 18 None 0.7851 None 0.999 N 0.821 0.495 0.720432007824 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 2.28781E-05 None 0 0 None 0 0 0 0 0
L/P 26897 Ig-139 18 rs754480353 0.9878 -1.36 1.0 N 0.821 0.597 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
L/P 26897 Ig-139 18 rs754480353 0.9878 -1.36 1.0 N 0.821 0.597 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
L/P 26897 Ig-139 18 rs754480353 0.9878 -1.36 1.0 N 0.821 0.597 None gnomAD-4.0.0 7.69039E-06 None None None None N None 0 8.48234E-05 None 0 0 None 0 0 2.39383E-06 0 0
F/L 27293 Ig-140 16 None 0.7883 None 0.999 N 0.567 0.42 0.395143324098 gnomAD-4.0.0 6.84439E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
F/S 27293 Ig-140 16 rs751553517 0.9485 -2.276 1.0 N 0.751 0.557 0.680157959374 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
F/S 27293 Ig-140 16 rs751553517 0.9485 -2.276 1.0 N 0.751 0.557 0.680157959374 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 3.66327E-05
L/V 27693 Ig-141 18 rs1329220257 0.2706 -0.903 0.618 N 0.589 0.057 0.252162846088 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.87E-06 0
L/V 27693 Ig-141 18 rs1329220257 0.2706 -0.903 0.618 N 0.589 0.057 0.252162846088 gnomAD-4.0.0 1.59144E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85886E-06 0 0
L/P 27980 Ig-142 18 rs1060500536 0.9719 None 0.142 N 0.535 0.418 0.728030011221 gnomAD-4.0.0 4.10741E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39806E-06 0 0
F/L 28772 Ig-144 18 rs574993385 0.9387 -1.262 0.999 N 0.582 0.432 0.248417906384 gnomAD-2.1.1 4.06E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
F/L 28772 Ig-144 18 rs574993385 0.9387 -1.262 0.999 N 0.582 0.432 0.248417906384 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
L/P 29062 Ig-145 18 rs2154156193 0.9899 None 1.0 N 0.882 0.692 0.677966677298 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/V 29062 Ig-145 18 rs1293928808 0.1236 -1.308 0.999 N 0.545 0.303 0.405560941015 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/V 29062 Ig-145 18 rs1293928808 0.1236 -1.308 0.999 N 0.545 0.303 0.405560941015 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02371E-05
V/L 29458 Ig-146 15 rs1575553466 0.3091 None 0.898 N 0.535 0.131 0.36256342048 gnomAD-4.0.0 3.60099E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.09898E-04
V/M 30149 Ig-148 18 rs1699816128 0.2056 None 0.901 N 0.665 0.262 0.388010793773 gnomAD-4.0.0 1.60543E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.04822E-05
L/F 30544 Ig-149 13 rs775973411 0.2053 -1.455 0.934 N 0.661 0.152 0.37479162749 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/F 30544 Ig-149 13 rs775973411 0.2053 -1.455 0.934 N 0.661 0.152 0.37479162749 gnomAD-4.0.0 1.59158E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
I/T 30943 Ig-150 17 None 0.9309 None 0.961 N 0.64 0.415 0.547470054201 gnomAD-4.0.0 1.59378E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
F/L 31233 Ig-151 16 None 0.9118 None 0.999 N 0.599 0.429 0.176091768786 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
L/S 32032 Ig-153 16 rs1267785229 0.9794 -2.546 0.999 N 0.839 0.518 0.738826834845 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
L/S 32032 Ig-153 16 rs1267785229 0.9794 -2.546 0.999 N 0.839 0.518 0.738826834845 gnomAD-4.0.0 1.59166E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85902E-06 0 0
V/A 32324 Ig-154 18 rs760371027 0.3968 -2.017 0.052 N 0.597 0.194 0.335414705075 gnomAD-2.1.1 4.04E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 4.65E-05 5.38E-05 0
V/A 32324 Ig-154 18 rs760371027 0.3968 -2.017 0.052 N 0.597 0.194 0.335414705075 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 32324 Ig-154 18 rs760371027 0.3968 -2.017 0.052 N 0.597 0.194 0.335414705075 gnomAD-4.0.0 1.48743E-05 None None None None N None 0 0 None 0 0 None 0 0 1.865E-05 2.19621E-05 0
V/I 32324 Ig-154 18 rs1454125243 0.0694 -0.439 None N 0.185 0.091 0.134241683229 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
V/I 32324 Ig-154 18 rs1454125243 0.0694 -0.439 None N 0.185 0.091 0.134241683229 gnomAD-4.0.0 3.1832E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71863E-06 0 0
I/F 32722 Ig-155 15 rs72648270 0.5306 -1.133 0.998 N 0.673 0.18 None gnomAD-2.1.1 2.57618E-02 None None None None I None 3.67769E-03 2.62518E-02 None 2.23361E-02 1.55699E-01 None 1.34305E-02 None 2.95858E-03 1.76198E-02 2.68033E-02
I/F 32722 Ig-155 15 rs72648270 0.5306 -1.133 0.998 N 0.673 0.18 None gnomAD-3.1.2 1.84986E-02 None None None None I None 4.36607E-03 2.73668E-02 4.38597E-03 2.36448E-02 1.46445E-01 None 1.60075E-03 5.06329E-02 1.77149E-02 1.24069E-02 3.53391E-02
I/F 32722 Ig-155 15 rs72648270 0.5306 -1.133 0.998 N 0.673 0.18 None 1000 genomes 4.25319E-02 None None None None I None 1.5E-03 2.88E-02 None None 1.488E-01 2.98E-02 None None None 1.12E-02 None
I/F 32722 Ig-155 15 rs72648270 0.5306 -1.133 0.998 N 0.673 0.18 None gnomAD-4.0.0 2.16917E-02 None None None None I None 4.22385E-03 2.72112E-02 None 2.28056E-02 1.61874E-01 None 2.87437E-03 7.50825E-02 1.83841E-02 1.32836E-02 2.52721E-02
I/L 32722 Ig-155 15 None 0.2178 None 0.889 N 0.383 0.164 0.294561560033 gnomAD-4.0.0 1.3684E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99471E-07 0 1.65662E-05
A/S 33118 Ig-156 18 rs1403450047 0.1774 -1.873 0.909 N 0.598 0.382 0.317084106153 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/T 33118 Ig-156 18 None 0.1984 None 0.994 N 0.663 0.449 0.319114376414 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85987E-06 0 0
V/G 33613 Ig-159 18 None 0.8953 None 0.942 N 0.829 0.473 0.685509544888 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 33613 Ig-159 18 rs1691163067 0.087 None None N 0.199 0.143 0.154104182512 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 33613 Ig-159 18 rs1691163067 0.087 None None N 0.199 0.143 0.154104182512 gnomAD-4.0.0 2.56487E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78696E-06 0 0
V/I 34153 Ig-160 17 rs1236074112 0.1106 -0.344 0.004 N 0.269 0.137 0.346085882481 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 8.88E-06 0
V/I 34153 Ig-160 17 rs1236074112 0.1106 -0.344 0.004 N 0.269 0.137 0.346085882481 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
V/I 34153 Ig-160 17 rs1236074112 0.1106 -0.344 0.004 N 0.269 0.137 0.346085882481 gnomAD-4.0.0 5.1235E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.67982E-05 5.68731E-05
V/I 34275 Ig-161 18 rs879063086 0.0844 -0.637 0.046 N 0.275 0.102 0.300449992093 gnomAD-2.1.1 1.61E-05 None None None None N None 1.93773E-04 0 None 0 0 None 0 None 0 0 1.65289E-04
V/I 34275 Ig-161 18 rs879063086 0.0844 -0.637 0.046 N 0.275 0.102 0.300449992093 gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
V/I 34275 Ig-161 18 rs879063086 0.0844 -0.637 0.046 N 0.275 0.102 0.300449992093 gnomAD-4.0.0 4.33746E-06 None None None None N None 8.00833E-05 0 None 0 0 None 0 0 0 0 1.60097E-05
V/I 34380 Ig-162 18 rs749967687 0.0865 -0.318 0.002 N 0.227 0.122 0.488266720666 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 34380 Ig-162 18 rs749967687 0.0865 -0.318 0.002 N 0.227 0.122 0.488266720666 gnomAD-4.0.0 3.42213E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69929E-06 2.31922E-05 0
V/L 34380 Ig-162 18 None 0.5065 None 0.034 D 0.491 0.124 0.391156786388 gnomAD-4.0.0 6.84425E-07 None None None None N None 0 2.23694E-05 None 0 0 None 0 0 0 0 0
A/P 35146 Ig-164 18 rs746800387 0.9361 0.218 1.0 N 0.819 0.532 0.31077124679 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
A/P 35146 Ig-164 18 rs746800387 0.9361 0.218 1.0 N 0.819 0.532 0.31077124679 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/P 35146 Ig-164 18 rs746800387 0.9361 0.218 1.0 N 0.819 0.532 0.31077124679 gnomAD-4.0.0 6.56978E-06 None None None None N None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
A/T 35146 Ig-164 18 rs746800387 0.2266 -0.932 0.992 N 0.595 0.299 0.207176502487 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
A/T 35146 Ig-164 18 rs746800387 0.2266 -0.932 0.992 N 0.595 0.299 0.207176502487 gnomAD-4.0.0 1.59087E-06 None None None None N None 0 0 None 0 2.77239E-05 None 0 0 0 0 0
A/E 35301 Ig-165 16 rs1354185370 0.902 None 0.761 N 0.673 0.26 0.377274123778 gnomAD-4.0.0 6.84151E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65645E-05
A/V 35301 Ig-165 16 rs1354185370 0.1298 0.467 0.001 N 0.163 0.093 0.1749357433 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/V 35301 Ig-165 16 rs1354185370 0.1298 0.467 0.001 N 0.163 0.093 0.1749357433 gnomAD-4.0.0 1.3683E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0
A/T 35437 Ig-166 18 None 0.1261 None None N 0.467 0.059 0.0846915920261 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 35719 Ig-168 18 None 0.321 None 0.002 N 0.305 0.209 0.370051654043 gnomAD-4.0.0 1.59318E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86103E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.