Structural position:

  • Domain Type: Ig
  • Aligned Position: 31
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
Q/R 124 Ig-2 21 rs1307913669 0.3363 -0.119 0.076 N 0.386 0.245 0.187945064343 gnomAD-2.1.1 3.99E-06 None None None -0.524(TCAP) N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
Q/R 124 Ig-2 21 rs1307913669 0.3363 -0.119 0.076 N 0.386 0.245 0.187945064343 gnomAD-4.0.0 1.59211E-06 None None None -0.524(TCAP) N None 0 0 None 0 0 None 0 0 2.85984E-06 0 0
E/D 963 Ig-3 21 rs1393032636 0.6848 -1.404 0.434 N 0.251 0.237 0.219573609325 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.63988E-04
E/D 963 Ig-3 21 rs1393032636 0.6848 -1.404 0.434 N 0.251 0.237 0.219573609325 gnomAD-4.0.0 1.59056E-06 None None None None N None 0 2.28624E-05 None 0 0 None 0 0 0 0 0
G/R 1102 Ig-4 21 rs1016142990 0.1766 None 0.017 N 0.46 0.161 0.62384306378 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
G/R 1102 Ig-4 21 rs1016142990 0.1766 None 0.017 N 0.46 0.161 0.62384306378 gnomAD-4.0.0 5.12184E-06 None None None None I None 1.68776E-05 5.08233E-05 None 0 0 None 0 0 0 0 0
H/P 1311 Ig-5 21 None 0.5826 None 1.0 N 0.703 0.635 0.643426271191 gnomAD-4.0.0 6.84211E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9942E-07 0 0
H/R 1311 Ig-5 21 None 0.3122 None 1.0 N 0.644 0.552 0.423480098753 gnomAD-4.0.0 1.36842E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31895E-05 0
D/H 1477 Ig-6 21 rs532313981 0.9437 0.197 1.0 N 0.754 0.527 0.415564226483 gnomAD-2.1.1 1.99E-05 None None None None I None 0 0 None 0 0 None 1.63335E-04 None 0 0 0
D/H 1477 Ig-6 21 rs532313981 0.9437 0.197 1.0 N 0.754 0.527 0.415564226483 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
D/H 1477 Ig-6 21 rs532313981 0.9437 0.197 1.0 N 0.754 0.527 0.415564226483 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
D/H 1477 Ig-6 21 rs532313981 0.9437 0.197 1.0 N 0.754 0.527 0.415564226483 gnomAD-4.0.0 4.33705E-06 None None None None I None 0 0 None 0 0 None 0 0 0 7.68859E-05 0
D/Y 1477 Ig-6 21 None 0.9316 None 1.0 D 0.778 0.521 0.755161906893 gnomAD-4.0.0 6.84128E-07 None None None None I None 2.98829E-05 0 None 0 0 None 0 0 0 0 0
K/N 1576 Ig-7 21 rs1249517281 0.2855 None 0.002 N 0.277 0.131 0.166414681773 gnomAD-4.0.0 1.20041E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3126E-06 0 0
K/T 1576 Ig-7 21 rs201686366 0.1182 -0.537 0.27 N 0.407 0.318 0.319402600006 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
K/T 1576 Ig-7 21 rs201686366 0.1182 -0.537 0.27 N 0.407 0.318 0.319402600006 gnomAD-4.0.0 1.59067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85691E-06 0 0
E/Q 1723 Ig-8 21 rs2092262638 0.5581 None 1.0 D 0.623 0.473 0.470484629704 gnomAD-4.0.0 1.59067E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85654E-06 0 0
R/C 1861 Ig-9 21 rs532733393 0.7117 -0.926 1.0 N 0.761 0.698 0.84442553596 gnomAD-2.1.1 6.01E-05 None None None None I None 4.01E-05 1.69348E-04 None 9.65E-05 5.02E-05 None 0 None 7.98E-05 3.87E-05 1.38351E-04
R/C 1861 Ig-9 21 rs532733393 0.7117 -0.926 1.0 N 0.761 0.698 0.84442553596 gnomAD-3.1.2 3.94E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 4.1511E-04 0
R/C 1861 Ig-9 21 rs532733393 0.7117 -0.926 1.0 N 0.761 0.698 0.84442553596 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
R/C 1861 Ig-9 21 rs532733393 0.7117 -0.926 1.0 N 0.761 0.698 0.84442553596 gnomAD-4.0.0 3.5935E-05 None None None None I None 2.66581E-05 9.99767E-05 None 0 2.22836E-05 None 6.25254E-05 0 2.96613E-05 5.49016E-05 7.99949E-05
R/H 1861 Ig-9 21 rs140914855 0.4693 -1.616 1.0 N 0.736 0.546 None gnomAD-2.1.1 8.49E-05 None None None None I None 4.01E-05 5.65E-05 None 0 0 None 0 None 0 1.39476E-04 4.15053E-04
R/H 1861 Ig-9 21 rs140914855 0.4693 -1.616 1.0 N 0.736 0.546 None gnomAD-3.1.2 3.29E-05 None None None None I None 0 6.55E-05 0 2.88184E-04 1.9253E-04 None 0 0 2.94E-05 0 0
R/H 1861 Ig-9 21 rs140914855 0.4693 -1.616 1.0 N 0.736 0.546 None gnomAD-4.0.0 7.99232E-05 None None None None I None 1.19939E-04 9.997E-05 None 3.37815E-05 6.68419E-05 None 0 4.9505E-04 8.81366E-05 0 4.79985E-05
R/G 2098 Ig-10 21 rs763722868 0.8746 -1.444 1.0 D 0.729 0.585 0.718442522405 gnomAD-2.1.1 1.2E-05 None None None None I None 0 8.69E-05 None 0 0 None 0 None 0 0 0
R/G 2098 Ig-10 21 rs763722868 0.8746 -1.444 1.0 D 0.729 0.585 0.718442522405 gnomAD-4.0.0 2.05228E-06 None None None None I None 0 6.71051E-05 None 0 0 None 0 0 0 0 0
R/Q 2098 Ig-10 21 rs565791174 0.2715 -0.494 1.0 N 0.705 0.429 0.434272847907 gnomAD-2.1.1 1.2E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.65E-05 0
R/Q 2098 Ig-10 21 rs565791174 0.2715 -0.494 1.0 N 0.705 0.429 0.434272847907 gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 2098 Ig-10 21 rs565791174 0.2715 -0.494 1.0 N 0.705 0.429 0.434272847907 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/Q 2098 Ig-10 21 rs565791174 0.2715 -0.494 1.0 N 0.705 0.429 0.434272847907 gnomAD-4.0.0 1.30108E-05 None None None None I None 1.33259E-05 0 None 0 8.91981E-05 None 0 0 1.35595E-05 0 0
R/W 2098 Ig-10 21 rs763722868 0.5614 -0.185 1.0 D 0.745 0.59 0.643776053401 gnomAD-2.1.1 1.2E-05 None None None None I None 0 8.69E-05 None 0 0 None 0 None 0 0 0
R/W 2098 Ig-10 21 rs763722868 0.5614 -0.185 1.0 D 0.745 0.59 0.643776053401 gnomAD-4.0.0 1.16296E-05 None None None None I None 1.19496E-04 6.71051E-05 None 0 0 None 1.87231E-05 0 7.1944E-06 1.15931E-05 0
E/G 2195 Ig-11 22 rs202032875 0.7508 -0.699 0.999 D 0.741 0.678 None gnomAD-2.1.1 1.94897E-04 None None None None N None 4.01E-05 0 None 0 0 None 0 None 2.78796E-04 3.65344E-04 0
E/G 2195 Ig-11 22 rs202032875 0.7508 -0.699 0.999 D 0.741 0.678 None gnomAD-3.1.2 2.10286E-04 None None None None N None 4.83E-05 0 0 0 0 None 3.76435E-04 0 3.67496E-04 0 4.77555E-04
E/G 2195 Ig-11 22 rs202032875 0.7508 -0.699 0.999 D 0.741 0.678 None gnomAD-4.0.0 2.67052E-04 None None None None N None 2.67001E-05 0 None 0 0 None 3.43632E-04 0 3.40683E-04 0 8.00179E-05
E/K 2287 Ig-12 21 rs1235978208 0.5668 -0.367 0.999 N 0.557 0.484 0.467074840246 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
E/K 2287 Ig-12 21 rs1235978208 0.5668 -0.367 0.999 N 0.557 0.484 0.467074840246 gnomAD-4.0.0 3.1822E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71406E-06 0 0
E/Q 2287 Ig-12 21 rs1235978208 0.2264 None 1.0 D 0.611 0.374 0.417081434665 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
E/Q 2287 Ig-12 21 rs1235978208 0.2264 None 1.0 D 0.611 0.374 0.417081434665 gnomAD-4.0.0 6.57151E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07211E-04 0
E/K 2376 Ig-13 21 rs1299039335 0.7851 -0.628 0.999 N 0.584 0.477 0.509463317838 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
E/K 2376 Ig-13 21 rs1299039335 0.7851 -0.628 0.999 N 0.584 0.477 0.509463317838 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 3.66327E-05
E/D 2465 Ig-14 21 rs1469271059 0.4708 -1.181 0.999 N 0.491 0.409 0.323615622048 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
E/K 2465 Ig-14 21 rs941805455 0.8033 None 0.999 D 0.571 0.576 0.517104213562 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 2465 Ig-14 21 rs941805455 0.8033 None 0.999 D 0.571 0.576 0.517104213562 gnomAD-4.0.0 5.12291E-06 None None None None N None 0 3.39018E-05 None 0 0 None 0 0 2.39198E-06 0 2.84236E-05
E/A 2553 Ig-15 21 rs367621583 0.3812 0.33 0.549 D 0.499 0.385 None gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 9.93E-05 0 None 0 None 0 0 0
E/A 2553 Ig-15 21 rs367621583 0.3812 0.33 0.549 D 0.499 0.385 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 2.88184E-04 0 None 0 0 0 0 0
E/A 2553 Ig-15 21 rs367621583 0.3812 0.33 0.549 D 0.499 0.385 None gnomAD-4.0.0 2.5618E-06 None None None None N None 0 0 None 8.17996E-05 0 None 0 0 0 0 0
E/G 2640 Ig-16 20 rs1343185312 0.3593 -1.134 1.0 D 0.731 0.646 0.609393688558 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
E/G 2640 Ig-16 20 rs1343185312 0.3593 -1.134 1.0 D 0.731 0.646 0.609393688558 gnomAD-4.0.0 2.05242E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69814E-06 0 0
T/A 2727 Ig-17 21 None 0.0854 None None D 0.197 0.088 0.220303561663 gnomAD-4.0.0 1.36817E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
E/A 2902 Ig-19 21 rs2091213467 0.3219 None 0.977 D 0.62 0.641 0.605955498237 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/A 2902 Ig-19 21 rs2091213467 0.3219 None 0.977 D 0.62 0.641 0.605955498237 gnomAD-4.0.0 3.84183E-06 None None None None N None 0 0 None 0 0 None 0 0 7.17525E-06 0 0
E/G 2902 Ig-19 21 None 0.5818 None 0.993 D 0.737 0.706 0.705062143596 gnomAD-4.0.0 1.59053E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
E/Q 2902 Ig-19 21 rs143767300 0.2092 -0.962 0.568 N 0.296 0.247 None gnomAD-2.1.1 7.97E-06 None None None None N None 1.23062E-04 0 None 0 0 None 0 None 0 0 0
E/Q 2902 Ig-19 21 rs143767300 0.2092 -0.962 0.568 N 0.296 0.247 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 2902 Ig-19 21 rs143767300 0.2092 -0.962 0.568 N 0.296 0.247 None gnomAD-4.0.0 2.5613E-06 None None None None N None 3.38341E-05 0 None 0 0 None 0 0 0 0 0
E/A 2989 Ig-20 21 rs1383280638 0.4765 -0.703 0.999 D 0.663 0.655 0.621448058205 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
E/A 2989 Ig-20 21 rs1383280638 0.4765 -0.703 0.999 D 0.663 0.655 0.621448058205 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/A 2989 Ig-20 21 rs1383280638 0.4765 -0.703 0.999 D 0.663 0.655 0.621448058205 gnomAD-4.0.0 2.56127E-06 None None None None N None 0 3.38926E-05 None 0 0 None 0 0 0 0 0
E/K 2989 Ig-20 21 None 0.5687 None 0.999 N 0.563 0.555 0.467501455318 gnomAD-4.0.0 6.84106E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9931E-07 0 0
E/G 3078 Ig-21 21 rs370704384 0.9061 -1.05 0.822 D 0.606 0.607 None gnomAD-2.1.1 3.98E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
E/Q 3078 Ig-21 21 rs1309287997 0.6444 None 0.971 D 0.631 0.39 0.426670027402 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 3078 Ig-21 21 rs1309287997 0.6444 None 0.971 D 0.631 0.39 0.426670027402 gnomAD-4.0.0 2.56117E-06 None None None None N None 0 0 None 0 0 None 0 0 4.7835E-06 0 0
C/R 3259 Ig-23 21 None 0.2092 None 0.002 N 0.46 0.388 0.627088449377 gnomAD-4.0.0 1.59077E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 2.85667E-06 0 0
C/S 3259 Ig-23 21 rs1258913609 0.1605 None 0.003 N 0.309 0.213 0.486282253068 gnomAD-3.1.2 1.31E-05 None None disulfide None N None 0 1.3089E-04 0 0 0 None 0 0 0 0 0
C/S 3259 Ig-23 21 rs1258913609 0.1605 None 0.003 N 0.309 0.213 0.486282253068 gnomAD-4.0.0 1.31409E-05 None None disulfide None N None 0 1.3089E-04 None 0 0 None 0 0 0 0 0
C/Y 3259 Ig-23 21 rs794729585 0.2611 None 0.921 N 0.523 0.338 0.658862992856 gnomAD-3.1.2 6.57E-06 None None disulfide None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/Y 3259 Ig-23 21 rs794729585 0.2611 None 0.921 N 0.523 0.338 0.658862992856 gnomAD-4.0.0 6.08966E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 7.22944E-06 0 0
H/N 3485 Ig-25 21 rs376698955 0.2566 -0.536 None None None 0.195 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
H/P 3485 Ig-25 21 None 0.6426 None None None None 0.311 None gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25002E-06 0 0
S/C 3840 Ig-27 21 None 0.1365 None 0.001 N 0.401 0.223 None gnomAD-4.0.0 6.84241E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15939E-05 0
S/F 3840 Ig-27 21 None 0.2028 None None N 0.542 0.221 None gnomAD-4.0.0 6.84241E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99497E-07 0 0
E/K 3958 Ig-28 21 None 0.1623 None 0.001 N 0.263 0.249 None gnomAD-4.0.0 6.84175E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99437E-07 0 0
T/K 4626 Ig-29 21 rs886039164 0.1286 None 0.029 N 0.479 0.067 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/K 4626 Ig-29 21 rs886039164 0.1286 None 0.029 N 0.479 0.067 None gnomAD-4.0.0 2.56214E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78556E-06 0 0
T/A 4720 Ig-30 21 None 0.1119 None 0.91 N 0.533 0.276 0.361160317528 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85905E-06 0 0
T/I 4720 Ig-30 21 rs373130116 0.1595 0.062 0.998 N 0.599 0.504 None gnomAD-2.1.1 8.05E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 4720 Ig-30 21 rs373130116 0.1595 0.062 0.998 N 0.599 0.504 None gnomAD-4.0.0 3.18402E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71817E-06 0 0
I/F 4815 Ig-31 21 rs1284454958 0.1 -1.058 0.029 N 0.337 0.139 0.404870348458 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
H/N 5002 Ig-33 22 None 0.0996 None 0.425 N 0.334 0.172 0.260249123532 gnomAD-4.0.0 1.59585E-06 None None None None N None 0 0 None 0 2.78691E-05 None 0 0 0 0 0
H/P 5002 Ig-33 22 None 0.2565 None 0.784 N 0.453 0.344 0.536988229258 gnomAD-4.0.0 1.59534E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43571E-05 0
H/Y 5002 Ig-33 22 None 0.1025 None 0.917 N 0.381 0.173 0.394230963961 gnomAD-4.0.0 1.59585E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03214E-05
Q/K 5095 Ig-34 21 None 0.1129 None 0.165 N 0.524 0.226 0.212008924253 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/R 5095 Ig-34 21 rs2081098001 0.1049 None 0.324 N 0.489 0.314 0.223847106136 gnomAD-4.0.0 1.50954E-05 None None None None N None 0 0 None 0 0 None 0 0 1.98325E-05 0 0
Q/K 5188 Ig-35 21 rs886038908 0.1055 0.061 0.997 D 0.45 0.351 0.371718192555 gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.35E-05 0
Q/K 5188 Ig-35 21 rs886038908 0.1055 0.061 0.997 D 0.45 0.351 0.371718192555 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
Q/K 5188 Ig-35 21 rs886038908 0.1055 0.061 0.997 D 0.45 0.351 0.371718192555 gnomAD-4.0.0 5.57778E-06 None None None None I None 0 0 None 0 2.22886E-05 None 0 0 6.78143E-06 0 0
Q/P 5188 Ig-35 21 rs72648930 0.3901 -0.001 0.999 N 0.732 0.561 None gnomAD-2.1.1 1.00032E-03 None None None None I None 4.54658E-04 2.83E-05 None 9.68E-05 0 None 0 None 1.60013E-04 1.99421E-03 1.12549E-03
Q/P 5188 Ig-35 21 rs72648930 0.3901 -0.001 0.999 N 0.732 0.561 None gnomAD-3.1.2 1.05818E-03 None None None None I None 3.13631E-04 1.31062E-04 1.09649E-03 0 0 None 9.41E-05 0 2.10251E-03 2.07125E-04 0
Q/P 5188 Ig-35 21 rs72648930 0.3901 -0.001 0.999 N 0.732 0.561 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
Q/P 5188 Ig-35 21 rs72648930 0.3901 -0.001 0.999 N 0.732 0.561 None gnomAD-4.0.0 1.73762E-03 None None None None I None 3.19829E-04 5.00067E-05 None 3.37883E-05 0 None 1.09348E-04 0 2.30229E-03 3.29439E-05 7.84326E-04
D/V 5377 Ig-37 21 None 0.3346 None 0.997 N 0.765 0.54 0.714182674065 gnomAD-4.0.0 1.59243E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
A/G 5564 Ig-39 22 rs1251516038 0.1244 -1.215 0.024 N 0.314 0.069 0.298403945805 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
A/G 5564 Ig-39 22 rs1251516038 0.1244 -1.215 0.024 N 0.314 0.069 0.298403945805 gnomAD-4.0.0 6.57428E-06 None None None None N None 0 0 None 0 0 None 9.42507E-05 0 0 0 0
Q/P 5750 Ig-41 21 None 0.6132 None 0.998 D 0.589 0.51 0.48512917806 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
Q/H 5843 Ig-42 21 rs2080404318 0.3228 None 0.988 N 0.501 0.315 0.303781844768 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
Q/K 5843 Ig-42 21 rs894175460 0.1515 None 0.826 N 0.445 0.253 0.19670166235 gnomAD-4.0.0 1.59146E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0248E-05
E/G 5939 Ig-43 21 None 0.6716 None 0.999 D 0.718 0.675 0.751210634423 gnomAD-4.0.0 1.59203E-06 None None None None N None 0 2.28749E-05 None 0 0 None 0 0 0 0 0
K/N 6032 Ig-44 21 None 0.3992 None 0.122 N 0.263 0.11 0.117506650769 gnomAD-4.0.0 6.85103E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00184E-07 0 0
E/A 6126 Ig-45 22 rs1328808708 0.1783 -0.906 0.822 N 0.513 0.418 0.534719010399 gnomAD-2.1.1 3.22E-05 None None None None N None 0 2.32585E-04 None 0 0 None 0 None 0 0 0
E/A 6126 Ig-45 22 rs1328808708 0.1783 -0.906 0.822 N 0.513 0.418 0.534719010399 gnomAD-4.0.0 7.52765E-06 None None None None N None 0 1.79083E-04 None 0 0 None 0 0 8.99528E-07 0 3.31444E-05
E/G 6126 Ig-45 22 rs1328808708 0.246 None 0.822 N 0.629 0.591 0.634345301216 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 6126 Ig-45 22 rs1328808708 0.246 None 0.822 N 0.629 0.591 0.634345301216 gnomAD-4.0.0 5.57816E-06 None None None None N None 0 0 None 0 0 None 0 0 7.62893E-06 0 0
E/Q 6126 Ig-45 22 rs1332146833 0.105 -0.704 0.126 N 0.367 0.187 0.264081493735 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/Q 6126 Ig-45 22 rs1332146833 0.105 -0.704 0.126 N 0.367 0.187 0.264081493735 gnomAD-4.0.0 3.18387E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71772E-06 0 0
E/D 6219 Ig-46 21 rs1282711943 0.2086 -1.031 0.896 D 0.498 0.167 0.126345400529 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
E/D 6219 Ig-46 21 rs1282711943 0.2086 -1.031 0.896 D 0.498 0.167 0.126345400529 gnomAD-4.0.0 6.84296E-07 None None None None N None 0 0 None 0 2.52003E-05 None 0 0 0 0 0
E/K 6219 Ig-46 21 rs72648948 0.1582 -0.522 0.896 N 0.496 0.178 None gnomAD-2.1.1 5.72E-05 None None None None N None 6.61704E-04 0 None 0 0 None 0 None 0 0 0
E/K 6219 Ig-46 21 rs72648948 0.1582 -0.522 0.896 N 0.496 0.178 None gnomAD-3.1.2 2.16917E-04 None None None None N None 6.99773E-04 1.96618E-04 0 0 0 None 0 0 0 0 4.77555E-04
E/K 6219 Ig-46 21 rs72648948 0.1582 -0.522 0.896 N 0.496 0.178 None gnomAD-4.0.0 3.03693E-05 None None None None N None 6.00897E-04 5.00334E-05 None 0 0 None 0 0 0 0 1.60128E-05
E/Q 6219 Ig-46 21 rs72648948 0.0983 -0.708 0.984 N 0.568 0.293 0.37262878642 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
E/Q 6219 Ig-46 21 rs72648948 0.0983 -0.708 0.984 N 0.568 0.293 0.37262878642 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/Q 6219 Ig-46 21 rs72648948 0.0983 -0.708 0.984 N 0.568 0.293 0.37262878642 gnomAD-4.0.0 3.71869E-06 None None None None N None 5.34131E-05 0 None 0 2.22876E-05 None 0 0 0 0 1.60128E-05
E/V 6219 Ig-46 21 rs2080005563 0.1453 None 0.938 D 0.627 0.438 0.759310620552 gnomAD-4.0.0 1.59174E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85927E-06 0 0
E/Q 6405 Ig-48 21 rs1431926097 0.1633 -0.07 0.998 N 0.642 0.318 0.441636318388 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/Q 6405 Ig-48 21 rs1431926097 0.1633 -0.07 0.998 N 0.642 0.318 0.441636318388 gnomAD-4.0.0 1.59412E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86541E-06 0 0
E/A 6688 Ig-51 22 rs1035063547 0.2985 -0.959 0.993 N 0.639 0.479 0.568285537894 gnomAD-2.1.1 8.07E-06 None None None None N None 1.294E-04 0 None 0 0 None 0 None 0 0 0
E/A 6688 Ig-51 22 rs1035063547 0.2985 -0.959 0.993 N 0.639 0.479 0.568285537894 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/A 6688 Ig-51 22 rs1035063547 0.2985 -0.959 0.993 N 0.639 0.479 0.568285537894 gnomAD-4.0.0 6.41213E-06 None None None None N None 8.46052E-05 0 None 0 0 None 0 0 0 0 0
E/A 6781 Ig-52 21 None 0.1653 None 0.917 N 0.55 0.413 0.555867075214 gnomAD-4.0.0 3.20496E-06 None None None None N None 0 0 None 0 0 None 0 0 5.75738E-06 0 0
E/K 6781 Ig-52 21 rs72648958 0.1937 -0.258 0.953 D 0.553 0.318 None gnomAD-2.1.1 9.93871E-04 None None None None N None 3.33417E-04 2.61203E-04 None 0 0 None 9.65894E-04 None 4.01994E-04 1.66299E-03 1.14384E-03
E/K 6781 Ig-52 21 rs72648958 0.1937 -0.258 0.953 D 0.553 0.318 None gnomAD-3.1.2 1.16377E-03 None None None None N None 4.58738E-04 1.96747E-04 0 0 0 None 2.82539E-04 0 2.19098E-03 6.20091E-04 0
E/K 6781 Ig-52 21 rs72648958 0.1937 -0.258 0.953 D 0.553 0.318 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
E/K 6781 Ig-52 21 rs72648958 0.1937 -0.258 0.953 D 0.553 0.318 None gnomAD-4.0.0 2.09579E-03 None None None None N None 4.14361E-04 2.18539E-04 None 3.39859E-05 0 None 5.32265E-04 9.94695E-04 2.61858E-03 1.07804E-03 1.71788E-03
E/Q 6781 Ig-52 21 rs72648958 0.1192 -0.495 0.99 N 0.571 0.259 0.303781844768 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
E/Q 6781 Ig-52 21 rs72648958 0.1192 -0.495 0.99 N 0.571 0.259 0.303781844768 gnomAD-4.0.0 1.37384E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80409E-06 0 0
Q/H 6874 Ig-53 21 None 0.2351 None 0.996 N 0.539 0.242 0.29385284311 gnomAD-4.0.0 1.5949E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86372E-06 0 0
Q/R 6874 Ig-53 21 rs749312103 0.0876 0.333 0.959 N 0.445 0.191 0.257786959452 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
Q/R 6874 Ig-53 21 rs749312103 0.0876 0.333 0.959 N 0.445 0.191 0.257786959452 gnomAD-4.0.0 1.36994E-06 None None None None N None 0 0 None 0 2.52105E-05 None 0 0 9.0009E-07 0 0
E/G 6968 Ig-54 21 None 0.4219 None 1.0 D 0.729 0.607 0.735594876934 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
E/G 7250 Ig-57 21 rs758430575 0.6276 -1.037 0.998 N 0.635 0.516 0.55563304408 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/G 7250 Ig-57 21 rs758430575 0.6276 -1.037 0.998 N 0.635 0.516 0.55563304408 gnomAD-4.0.0 1.59181E-06 None None None None I None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
Q/K 7343 Ig-58 21 rs886043434 0.0995 None 0.048 N 0.167 0.234 0.190952846119 gnomAD-4.0.0 1.59307E-06 None None None None I None 0 0 None 0 2.77932E-05 None 0 0 0 0 0
Q/R 7343 Ig-58 21 rs1215230781 0.1005 None 0.744 N 0.402 0.265 0.278968121808 gnomAD-4.0.0 1.59294E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86059E-06 0 0
T/I 7439 Ig-59 21 rs2078562379 0.1721 None 0.27 N 0.427 0.228 0.606262950116 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
T/P 7439 Ig-59 21 rs772268509 0.2198 -0.549 0.784 N 0.445 0.29 0.645914728649 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/P 7439 Ig-59 21 rs772268509 0.2198 -0.549 0.784 N 0.445 0.29 0.645914728649 gnomAD-4.0.0 1.36871E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79929E-06 0 0
E/G 7535 Ig-60 21 rs773956492 0.4437 None 0.896 N 0.623 0.507 0.644471222209 gnomAD-4.0.0 6.00161E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
Q/R 7722 Ig-62 21 None 0.1079 None 0.801 N 0.487 0.32 0.277730125212 gnomAD-4.0.0 1.59252E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86002E-06 0 0
R/G 7815 Ig-63 21 None 0.1326 None 0.058 N 0.424 0.273 0.591730238936 gnomAD-4.0.0 6.84262E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99523E-07 0 0
R/P 7815 Ig-63 21 None 0.6421 None 0.232 N 0.527 0.284 0.183819452728 gnomAD-4.0.0 6.8426E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99518E-07 0 0
R/Q 7815 Ig-63 21 rs372804810 0.0594 0.155 None N 0.213 0.137 None gnomAD-2.1.1 4.03E-05 None None None None I None 0 8.7E-05 None 0 5.57E-05 None 3.27E-05 None 0 4.46E-05 0
R/Q 7815 Ig-63 21 rs372804810 0.0594 0.155 None N 0.213 0.137 None gnomAD-3.1.2 3.94E-05 None None None None I None 0 2.61814E-04 0 0 0 None 0 0 2.94E-05 0 0
R/Q 7815 Ig-63 21 rs372804810 0.0594 0.155 None N 0.213 0.137 None gnomAD-4.0.0 3.40853E-05 None None None None I None 0 1.667E-04 None 0 8.91544E-05 None 1.56279E-05 1.64474E-04 2.79726E-05 3.29381E-05 4.80384E-05
R/W 7815 Ig-63 21 rs528264100 0.1486 -0.106 0.964 N 0.471 0.336 0.55355060856 gnomAD-2.1.1 4.03E-05 None None None None I None 6.47E-05 8.7E-05 None 9.97E-05 0 None 6.54E-05 None 0 2.68E-05 0
R/W 7815 Ig-63 21 rs528264100 0.1486 -0.106 0.964 N 0.471 0.336 0.55355060856 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 1.92901E-04 None 0 0 1.47E-05 2.06782E-04 4.78927E-04
R/W 7815 Ig-63 21 rs528264100 0.1486 -0.106 0.964 N 0.471 0.336 0.55355060856 gnomAD-4.0.0 2.29286E-05 None None None None I None 1.33294E-05 1.16674E-04 None 3.37838E-05 4.45871E-05 None 0 3.30142E-04 1.35626E-05 6.5879E-05 3.20133E-05
E/G 7909 Ig-64 21 None 0.5004 None 0.994 D 0.646 0.592 0.610906440916 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/Q 7909 Ig-64 21 rs1161435142 0.2042 -0.388 0.998 D 0.65 0.474 0.436993770938 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/Q 7909 Ig-64 21 rs1161435142 0.2042 -0.388 0.998 D 0.65 0.474 0.436993770938 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 7909 Ig-64 21 rs1161435142 0.2042 -0.388 0.998 D 0.65 0.474 0.436993770938 gnomAD-4.0.0 2.23122E-05 None None None None I None 0 0 None 3.37861E-05 0 None 0 0 2.8822E-05 0 1.60159E-05
E/Q 8005 Ig-65 21 rs757042397 0.1759 -0.761 0.998 N 0.545 0.251 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
E/Q 8005 Ig-65 21 rs757042397 0.1759 -0.761 0.998 N 0.545 0.251 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 8005 Ig-65 21 rs757042397 0.1759 -0.761 0.998 N 0.545 0.251 None gnomAD-4.0.0 2.97473E-05 None None None None N None 0 0 None 0 0 None 0 0 3.98397E-05 0 1.60113E-05
T/S 8098 Ig-66 21 rs2077908653 0.1211 None None N 0.25 0.167 0.158396225186 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 8098 Ig-66 21 rs2077908653 0.1211 None None N 0.25 0.167 0.158396225186 gnomAD-4.0.0 2.56414E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78849E-06 0 0
E/G 8191 Ig-67 21 None 0.7266 None 0.068 D 0.375 0.42 0.421060224861 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 8191 Ig-67 21 rs201326258 0.7278 0.524 0.996 D 0.547 0.366 0.38225645794 gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 5.58E-05 None 6.54E-05 None 0 3.57E-05 1.66334E-04
E/K 8191 Ig-67 21 rs201326258 0.7278 0.524 0.996 D 0.547 0.366 0.38225645794 gnomAD-3.1.2 3.94E-05 None None None None I None 2.41E-05 1.30959E-04 0 0 0 None 0 0 1.47E-05 0 9.57854E-04
E/K 8191 Ig-67 21 rs201326258 0.7278 0.524 0.996 D 0.547 0.366 0.38225645794 gnomAD-4.0.0 1.67332E-05 None None None None I None 2.67051E-05 3.334E-05 None 0 4.45792E-05 None 0 1.64474E-04 1.35624E-05 2.19635E-05 3.20287E-05
E/Q 8191 Ig-67 21 None 0.4428 None 0.999 N 0.587 0.398 0.375861065471 gnomAD-4.0.0 1.36851E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79901E-06 0 0
Q/E 8284 Ig-68 21 None 0.106 None 0.001 N 0.229 0.164 0.188950314367 gnomAD-4.0.0 2.40066E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
Q/L 8284 Ig-68 21 None 0.1494 None 0.269 N 0.514 0.209 0.442054744378 gnomAD-4.0.0 3.21576E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71948E-06 0 0
K/T 8476 Ig-70 21 None 0.1157 None 0.478 N 0.455 0.479 0.393471546983 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
E/K 8570 Ig-71 22 rs552462622 0.2803 -0.253 0.883 N 0.487 0.404 None gnomAD-2.1.1 4.12E-05 None None None None N None 0 0 None 0 0 None 0 None 4.08E-05 8.26E-05 0
E/K 8570 Ig-71 22 rs552462622 0.2803 -0.253 0.883 N 0.487 0.404 None gnomAD-3.1.2 7.23E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 1.02938E-04 0 0
E/K 8570 Ig-71 22 rs552462622 0.2803 -0.253 0.883 N 0.487 0.404 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
E/K 8570 Ig-71 22 rs552462622 0.2803 -0.253 0.883 N 0.487 0.404 None gnomAD-4.0.0 1.44985E-04 None None None None N None 5.33732E-05 0 None 0 0 None 4.71313E-05 0 1.9045E-04 0 3.21399E-05
Q/H 8756 Ig-73 21 rs776025006 0.1926 -0.967 0.993 N 0.529 0.304 0.346315397577 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/H 8756 Ig-73 21 rs776025006 0.1926 -0.967 0.993 N 0.529 0.304 0.346315397577 gnomAD-4.0.0 1.5923E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43377E-05 0
Q/R 8756 Ig-73 21 rs761090454 0.0928 -0.06 0.901 N 0.506 0.199 0.225215365344 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/K 8850 Ig-74 21 None 0.3468 None 0.998 D 0.517 0.352 0.502691689211 gnomAD-4.0.0 6.84258E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9951E-07 0 0
E/Q 8850 Ig-74 21 rs2077103240 0.1758 None 0.999 N 0.629 0.292 0.441844919209 gnomAD-4.0.0 6.84258E-07 None None None None N None 0 0 None 0 2.51978E-05 None 0 0 0 0 0
T/I 9039 Ig-76 21 rs1560585408 0.1886 None 0.023 N 0.371 0.34 0.47737504017 gnomAD-4.0.0 1.59269E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
T/R 9039 Ig-76 21 None 0.1067 None 0.642 D 0.565 0.281 0.586816528483 gnomAD-4.0.0 1.59269E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
Q/P 9225 Ig-78 21 None 0.6797 None 0.917 N 0.515 0.429 0.506128173473 gnomAD-4.0.0 1.59124E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
Q/R 9225 Ig-78 21 rs2076750199 0.1374 None 0.006 N 0.189 0.16 0.183819452728 gnomAD-4.0.0 4.77371E-06 None None None None I None 0 0 None 0 0 None 0 0 8.57491E-06 0 0
D/Y 9321 Ig-79 21 rs762498001 0.2552 0.282 0.859 None 0.732 0.368 0.802398120638 gnomAD-4.0.0 4.77797E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.31072E-05 0
E/D 9417 Ig-80 21 rs773169301 0.2077 -0.89 0.998 None 0.47 0.287 0.293147016451 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 1.11309E-04 None 0 None 0 0 0
E/D 9417 Ig-80 21 rs773169301 0.2077 -0.89 0.998 None 0.47 0.287 0.293147016451 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 3.85356E-04 None 0 0 0 0 0
E/D 9417 Ig-80 21 rs773169301 0.2077 -0.89 0.998 None 0.47 0.287 0.293147016451 gnomAD-4.0.0 3.09838E-06 None None None None I None 0 0 None 0 1.11388E-04 None 0 0 0 0 0
S/N 9610 Ig-82 21 rs371759532 0.1485 -0.597 0.062 None 0.455 0.09 None gnomAD-2.1.1 7.49E-05 None None None None N None 8.67912E-04 0 None 0 0 None 0 None 0 0 0
S/N 9610 Ig-82 21 rs371759532 0.1485 -0.597 0.062 None 0.455 0.09 None gnomAD-3.1.2 1.97055E-04 None None None None N None 7.2338E-04 0 0 0 0 None 0 0 0 0 0
S/N 9610 Ig-82 21 rs371759532 0.1485 -0.597 0.062 None 0.455 0.09 None gnomAD-4.0.0 3.408E-05 None None None None N None 7.20519E-04 0 None 0 0 None 0 0 0 0 1.60108E-05
I/F 9718 Ig-83 21 None 0.1867 None 0.994 None 0.593 0.328 0.524428966543 gnomAD-4.0.0 6.86504E-07 None None None None I None 0 0 None 0 0 None 0 0 9.02094E-07 0 0
I/S 9718 Ig-83 21 rs4893852 0.5222 -1.33 0.961 None 0.619 0.388 0.82519668701 gnomAD-2.1.1 1.21E-05 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 1.78E-05 0
I/S 9718 Ig-83 21 rs4893852 0.5222 -1.33 0.961 None 0.619 0.388 0.82519668701 gnomAD-3.1.2 3.29E-05 None None None None I None 2.42E-05 0 0 0 0 None 0 0 5.88E-05 0 0
I/S 9718 Ig-83 21 rs4893852 0.5222 -1.33 0.961 None 0.619 0.388 0.82519668701 gnomAD-4.0.0 2.05126E-05 None None None None I None 2.67938E-05 0 None 0 0 None 0 0 2.4649E-05 0 3.21223E-05
I/T 9718 Ig-83 21 rs4893852 0.214 -1.165 0.4 None 0.423 0.216 None gnomAD-2.1.1 8.25144E-02 None None None None I None 2.03964E-01 1.93592E-01 None 4.09357E-02 2.89833E-02 None 1.68648E-01 None 5.63403E-02 2.67532E-02 6.09997E-02
I/T 9718 Ig-83 21 rs4893852 0.214 -1.165 0.4 None 0.423 0.216 None gnomAD-3.1.2 9.38774E-02 None None None None I None 2.01368E-01 1.51795E-01 4.27632E-02 3.60438E-02 2.61639E-02 None 5.75146E-02 5.37975E-02 2.60055E-02 1.60796E-01 7.53359E-02
I/T 9718 Ig-83 21 rs4893852 0.214 -1.165 0.4 None 0.423 0.216 None 1000 genomes 1.27396E-01 None None None None I None 2.231E-01 1.556E-01 None None 2.58E-02 3.58E-02 None None None 1.769E-01 None
I/T 9718 Ig-83 21 rs4893852 0.214 -1.165 0.4 None 0.423 0.216 None gnomAD-4.0.0 5.01499E-02 None None None None I None 2.04865E-01 1.81335E-01 None 3.95272E-02 1.50879E-02 None 5.8165E-02 4.82107E-02 2.61123E-02 1.59647E-01 5.62602E-02
I/V 9718 Ig-83 21 rs748067330 0.1002 -0.89 0.817 None 0.411 0.193 0.610064410546 gnomAD-2.1.1 1.21E-05 None None None None I None 0 8.77E-05 None 0 0 None 0 None 0 0 0
I/V 9718 Ig-83 21 rs748067330 0.1002 -0.89 0.817 None 0.411 0.193 0.610064410546 gnomAD-4.0.0 2.74602E-06 None None None None I None 0 6.75676E-05 None 0 0 None 1.87413E-05 0 0 0 0
T/I 10009 Ig-85 21 None 0.162 None 0.193 None 0.597 0.243 0.626364337782 gnomAD-4.0.0 1.59086E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85747E-06 0 0
E/G 13707 Ig-87 24 None 0.8488 None 0.993 D 0.749 0.659 0.711402520684 gnomAD-4.0.0 2.05305E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69881E-06 0 0
E/Q 13707 Ig-87 24 rs1173154586 0.5793 -0.795 0.997 N 0.687 0.336 0.411401001288 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/G 13801 Ig-88 22 None 0.2443 None 0.101 N 0.487 0.145 0.15556083564 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
S/N 13801 Ig-88 22 rs757590541 0.2793 -0.688 0.001 N 0.334 0.054 0.0954503805726 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 2.2668E-04 None 0 None 0 0 0
S/N 13801 Ig-88 22 rs757590541 0.2793 -0.688 0.001 N 0.334 0.054 0.0954503805726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93949E-04 None 0 0 0 0 0
S/N 13801 Ig-88 22 rs757590541 0.2793 -0.688 0.001 N 0.334 0.054 0.0954503805726 gnomAD-4.0.0 3.8493E-06 None None None None N None 0 0 None 0 4.88329E-05 None 0 0 0 0 2.84787E-05
A/V 13894 Ig-89 19 rs1409834949 0.1326 -0.225 0.006 N 0.362 0.056 0.333651784274 gnomAD-2.1.1 4.46E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1E-05 0
A/V 13894 Ig-89 19 rs1409834949 0.1326 -0.225 0.006 N 0.362 0.056 0.333651784274 gnomAD-4.0.0 1.63189E-06 None None None None N None 0 0 None 0 0 None 0 0 2.92665E-06 0 0
D/E 13985 Ig-90 21 None 0.2313 None None N 0.227 0.056 0.0551355673512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 13985 Ig-90 21 rs779561282 0.6565 -0.43 0.189 N 0.597 0.225 0.0986583533028 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
D/G 13985 Ig-90 21 rs779561282 0.6565 -0.43 0.189 N 0.597 0.225 0.0986583533028 gnomAD-4.0.0 4.77681E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72014E-06 0 3.02608E-05
E/K 14074 Ig-91 21 rs1418024772 0.6846 -0.282 1.0 N 0.59 0.441 0.494974121195 gnomAD-2.1.1 6.37E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 14074 Ig-91 21 rs1418024772 0.6846 -0.282 1.0 N 0.59 0.441 0.494974121195 gnomAD-3.1.2 4.6E-05 None None None None N None 1.20744E-04 0 0 0 0 None 0 0 1.47E-05 2.07297E-04 0
E/K 14074 Ig-91 21 rs1418024772 0.6846 -0.282 1.0 N 0.59 0.441 0.494974121195 gnomAD-4.0.0 2.29339E-05 None None None None N None 9.33831E-05 0 None 0 0 None 0 0 2.1195E-05 4.39338E-05 1.60113E-05
E/Q 14074 Ig-91 21 rs1418024772 0.384 None 1.0 D 0.635 0.443 0.528059499947 gnomAD-4.0.0 6.84384E-07 None None None None N None 2.9915E-05 0 None 0 0 None 0 0 0 0 0
V/A 14162 Ig-92 21 None 0.1131 None 0.047 N 0.289 0.121 0.454893017966 gnomAD-4.0.0 3.18434E-06 None None None None N None 0 0 None 0 0 None 1.88296E-05 0 2.86012E-06 0 0
E/D 14339 Ig-94 21 rs1353557766 0.507 None 0.997 N 0.618 0.176 0.194818534648 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 14339 Ig-94 21 rs1353557766 0.507 None 0.997 N 0.618 0.176 0.194818534648 gnomAD-4.0.0 6.57393E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47063E-05 0 0
E/D 14428 Ig-95 21 rs1261167534 0.3012 -1.076 0.434 N 0.247 0.091 0.241078983079 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
E/D 14428 Ig-95 21 rs1261167534 0.3012 -1.076 0.434 N 0.247 0.091 0.241078983079 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 14428 Ig-95 21 rs1261167534 0.3012 -1.076 0.434 N 0.247 0.091 0.241078983079 gnomAD-4.0.0 1.42569E-05 None None None None N None 1.33497E-05 0 None 0 0 None 0 0 1.86509E-05 0 0
T/A 14517 Ig-96 21 rs2154220669 0.1098 None 0.454 N 0.462 0.256 0.449088463789 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 14517 Ig-96 21 rs2154220669 0.1098 None 0.454 N 0.462 0.256 0.449088463789 gnomAD-4.0.0 6.5722E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47137E-05 0 0
D/N 14784 Ig-99 20 None 0.1659 -0.436 0.88 N 0.581 0.174 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 1.78E-05 0
D/N 14784 Ig-99 20 None 0.1659 -0.436 0.88 N 0.581 0.174 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/N 14784 Ig-99 20 None 0.1659 -0.436 0.88 N 0.581 0.174 None gnomAD-4.0.0 2.9142E-05 None None None None N None 0 0 None 0 0 None 0 0 3.64612E-05 4.39367E-05 0
D/Y 14784 Ig-99 20 rs72677216 0.3187 0.459 0.921 D 0.718 0.418 0.700597166766 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/Y 14784 Ig-99 20 rs72677216 0.3187 0.459 0.921 D 0.718 0.418 0.700597166766 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
D/Y 14784 Ig-99 20 rs72677216 0.3187 0.459 0.921 D 0.718 0.418 0.700597166766 gnomAD-4.0.0 9.30066E-06 None None None None N None 0 0 None 0 0 None 0 0 1.10232E-05 0 3.20472E-05
E/A 14873 Ig-100 21 None 0.2654 None 0.919 D 0.591 0.496 None gnomAD-4.0.0 1.59391E-06 None None None None N None 5.67537E-05 0 None 0 0 None 0 0 0 0 0
E/A 14962 Ig-101 21 None 0.4352 None 0.999 D 0.68 0.609 0.661757452181 gnomAD-4.0.0 4.80958E-06 None None None None N None 0 0 None 0 0 None 0 0 6.3124E-06 0 0
E/G 14962 Ig-101 21 None 0.6616 None 1.0 D 0.741 0.61 0.729396383729 gnomAD-4.0.0 6.87083E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.17697E-05 0
E/Q 14962 Ig-101 21 rs879066606 0.2935 -0.794 1.0 D 0.624 0.376 None gnomAD-2.1.1 4.15E-06 None None None None N None 6.86E-05 0 None 0 0 None 0 None 0 0 0
E/Q 14962 Ig-101 21 rs879066606 0.2935 -0.794 1.0 D 0.624 0.376 None gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
E/Q 14962 Ig-101 21 rs879066606 0.2935 -0.794 1.0 D 0.624 0.376 None gnomAD-4.0.0 3.8762E-06 None None None None N None 1.69929E-05 0 None 0 0 None 0 0 4.82097E-06 0 0
V/A 15051 Ig-102 21 rs751236128 0.1559 -1.713 0.174 N 0.577 0.182 0.645517457789 gnomAD-2.1.1 2.03E-05 None None None None N None 0 0 None 0 0 None 1.63506E-04 None 0 0 0
V/A 15051 Ig-102 21 rs751236128 0.1559 -1.713 0.174 N 0.577 0.182 0.645517457789 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07469E-04 0
V/A 15051 Ig-102 21 rs751236128 0.1559 -1.713 0.174 N 0.577 0.182 0.645517457789 gnomAD-4.0.0 1.61287E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.8557E-04 0
V/I 15140 Ig-103 21 None 0.0739 None None N 0.267 0.078 0.624871295421 gnomAD-4.0.0 1.59516E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86356E-06 0 0
N/I 15228 Ig-104 21 None 0.2341 None 0.971 N 0.702 0.516 0.772084405115 gnomAD-4.0.0 1.59407E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86257E-06 0 0
W/C 15322 Ig-105 21 rs2058105154 0.3894 None 0.006 N 0.418 0.33 0.473458370588 gnomAD-4.0.0 6.85008E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00121E-07 0 0
L/S 15500 Ig-107 21 rs529804754 0.188 -2.182 None N 0.325 0.09 None gnomAD-2.1.1 4.04E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
L/S 15500 Ig-107 21 rs529804754 0.188 -2.182 None N 0.325 0.09 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/S 15500 Ig-107 21 rs529804754 0.188 -2.182 None N 0.325 0.09 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
L/S 15500 Ig-107 21 rs529804754 0.188 -2.182 None N 0.325 0.09 None gnomAD-4.0.0 6.57817E-06 None None None None N None 2.4079E-05 0 None 0 0 None 0 0 0 0 0
V/A 15588 Ig-108 21 None 0.0936 None 0.003 N 0.175 0.142 0.463328977263 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/M 15588 Ig-108 21 rs768229241 0.1036 -0.391 0.655 N 0.475 0.139 0.465721554213 gnomAD-2.1.1 8.1E-06 None None None None N None 0 2.92E-05 None 0 0 None 3.27E-05 None 0 0 0
V/M 15588 Ig-108 21 rs768229241 0.1036 -0.391 0.655 N 0.475 0.139 0.465721554213 gnomAD-4.0.0 4.79013E-06 None None None None N None 0 2.29421E-05 None 0 0 None 0 0 0 2.87043E-05 0
P/A 16279 Ig-110 18 rs867039661 0.3755 None 1.0 D 0.735 0.4 0.542144099713 gnomAD-4.0.0 6.84814E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99973E-07 0 0
P/L 16279 Ig-110 18 None 0.4863 None 1.0 D 0.798 0.489 0.790236128783 gnomAD-4.0.0 1.59456E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86338E-06 0 0
P/T 16279 Ig-110 18 None 0.4539 None 1.0 N 0.794 0.372 0.530803083455 gnomAD-4.0.0 1.36963E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79995E-06 0 0
P/S 16975 Ig-111 21 None 0.1479 None 0.322 N 0.372 0.147 0.267299060538 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/A 17268 Ig-112 18 None 0.2094 None 0.565 N 0.617 0.357 0.421060224861 gnomAD-4.0.0 4.10815E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39949E-06 0 0
P/L 17693 Ig-113 17 rs1176166730 0.3368 -0.027 0.999 N 0.789 0.408 0.680317807054 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
P/L 17693 Ig-113 17 rs1176166730 0.3368 -0.027 0.999 N 0.789 0.408 0.680317807054 gnomAD-4.0.0 1.59267E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86069E-06 0 0
P/T 17693 Ig-113 17 None 0.3073 None 0.998 N 0.756 0.416 0.531825494424 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/T 17987 Ig-114 20 rs1315555738 0.2458 -0.78 1.0 N 0.745 0.418 0.619976913611 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.01E-06 0
P/S 18399 Ig-115 18 rs774591174 0.3141 -0.79 0.987 N 0.76 0.356 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
P/S 18399 Ig-115 18 rs774591174 0.3141 -0.79 0.987 N 0.76 0.356 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
P/S 18399 Ig-115 18 rs774591174 0.3141 -0.79 0.987 N 0.76 0.356 None gnomAD-4.0.0 1.0542E-05 None None None None I None 1.33643E-05 0 None 0 0 None 0 0 1.35683E-05 0 0
P/T 18399 Ig-115 18 None 0.2343 None 0.568 N 0.383 0.297 0.461845970543 gnomAD-4.0.0 4.79225E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29896E-06 0 0
V/M 18705 Ig-116 18 rs1297839947 0.125 -0.337 0.982 N 0.611 0.172 0.612178117122 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 3.31E-05 None 0 0 0
V/M 18705 Ig-116 18 rs1297839947 0.125 -0.337 0.982 N 0.611 0.172 0.612178117122 gnomAD-4.0.0 5.48359E-06 None None None None I None 0 0 None 0 0 None 0 0 5.40201E-06 2.3334E-05 0
I/T 19113 Ig-117 19 None 0.5654 None 0.997 N 0.591 0.401 0.817057561884 gnomAD-4.0.0 1.59239E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02627E-05
I/V 19113 Ig-117 19 rs2052104416 0.1842 None 0.798 N 0.4 0.143 0.59589940523 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
I/V 19113 Ig-117 19 rs2052104416 0.1842 None 0.798 N 0.4 0.143 0.59589940523 gnomAD-4.0.0 2.56395E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.68053E-05 0
T/I 19407 Ig-118 17 None 0.1531 None 0.295 D 0.532 0.168 0.422404719673 gnomAD-4.0.0 1.59219E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85935E-06 0 0
S/R 19807 Ig-119 18 None 0.8892 None 0.994 N 0.593 0.479 0.517322629239 gnomAD-4.0.0 6.84331E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9958E-07 0 0
P/R 20099 Ig-120 20 None 0.7963 None 1.0 N 0.725 0.437 0.613292534842 gnomAD-4.0.0 6.87377E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01832E-07 0 0
L/P 20497 Ig-121 19 None 0.305 None 0.523 N 0.66 0.315 0.739242410713 gnomAD-4.0.0 2.08202E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81538E-06 1.21966E-05 0
L/V 20497 Ig-121 19 rs1323115557 0.0839 -1.481 0.003 N 0.226 0.113 0.649506424125 gnomAD-2.1.1 4.36E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.5E-06 0
L/V 20497 Ig-121 19 rs1323115557 0.0839 -1.481 0.003 N 0.226 0.113 0.649506424125 gnomAD-4.0.0 1.64792E-06 None None None None N None 0 0 None 0 0 None 0 0 2.94726E-06 0 0
E/A 20790 Ig-122 22 None 0.368 None 0.996 N 0.515 0.612 0.541875726618 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 21487 Ig-124 19 rs2048679694 0.2936 None 0.275 N 0.261 0.085 0.30212335484 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
E/D 21487 Ig-124 19 rs2048679694 0.2936 None 0.275 N 0.261 0.085 0.30212335484 gnomAD-4.0.0 2.56766E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.34647E-05 2.84917E-05
E/K 21487 Ig-124 19 rs1485546407 0.4677 None 0.992 N 0.525 0.401 0.421427970867 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 21487 Ig-124 19 rs1485546407 0.4677 None 0.992 N 0.525 0.401 0.421427970867 gnomAD-4.0.0 4.96307E-06 None None None None N None 0 0 None 0 0 None 0 0 6.7856E-06 0 0
D/N 21884 Ig-125 19 rs1350675904 0.1193 -0.839 0.549 N 0.489 0.214 0.30212335484 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
D/N 21884 Ig-125 19 rs1350675904 0.1193 -0.839 0.549 N 0.489 0.214 0.30212335484 gnomAD-4.0.0 4.78348E-06 None None None None N None 0 0 None 0 0 None 0 0 8.59161E-06 0 0
Y/H 22282 Ig-126 18 rs745992545 0.4189 -0.151 0.998 N 0.663 0.299 None gnomAD-2.1.1 2.87E-05 None None None None I None 3.31181E-04 0 None 0 0 None 0 None 0 0 0
Y/H 22282 Ig-126 18 rs745992545 0.4189 -0.151 0.998 N 0.663 0.299 None gnomAD-3.1.2 9.86E-05 None None None None I None 3.61829E-04 0 0 0 0 None 0 0 0 0 0
Y/H 22282 Ig-126 18 rs745992545 0.4189 -0.151 0.998 N 0.663 0.299 None gnomAD-4.0.0 1.67421E-05 None None None None I None 3.60567E-04 0 None 0 0 None 0 0 0 0 0
K/M 22571 Ig-127 12 None 0.3537 None 1.0 N 0.581 0.589 0.488477830397 gnomAD-4.0.0 1.60181E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43724E-05 0
K/N 22571 Ig-127 12 None 0.4962 None 0.122 N 0.251 0.17 0.210429274316 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 22967 Ig-128 18 None 0.0588 None None N 0.205 0.127 0.0401082797425 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 24050 Ig-131 22 rs771209223 0.2023 -1.032 0.896 D 0.61 0.604 0.686624564747 gnomAD-2.1.1 8.06E-05 None None None None N None 0 0 None 0 0 None 6.21199E-04 None 0 0 1.66279E-04
E/G 24050 Ig-131 22 rs771209223 0.2023 -1.032 0.896 D 0.61 0.604 0.686624564747 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.21633E-04 0
E/G 24050 Ig-131 22 rs771209223 0.2023 -1.032 0.896 D 0.61 0.604 0.686624564747 gnomAD-4.0.0 3.40915E-05 None None None None N None 0 0 None 0 0 None 0 0 0 5.60046E-04 6.40656E-05
E/K 24050 Ig-131 22 None 0.2238 None 0.026 N 0.411 0.288 0.406668915854 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
D/G 24736 Ig-133 21 rs762510108 0.3161 0.276 0.892 N 0.545 0.502 0.381916209588 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/G 24736 Ig-133 21 rs762510108 0.3161 0.276 0.892 N 0.545 0.502 0.381916209588 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/G 24736 Ig-133 21 rs762510108 0.3161 0.276 0.892 N 0.545 0.502 0.381916209588 gnomAD-4.0.0 2.47967E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39111E-06 0 0
F/I 25531 Ig-135 18 rs878933531 0.5625 None 0.805 N 0.441 0.415 None gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
F/S 25531 Ig-135 18 rs976954474 0.7187 -1.898 0.983 N 0.707 0.543 0.802449804186 gnomAD-2.1.1 7.16E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
F/S 25531 Ig-135 18 rs976954474 0.7187 -1.898 0.983 N 0.707 0.543 0.802449804186 gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
F/S 25531 Ig-135 18 rs976954474 0.7187 -1.898 0.983 N 0.707 0.543 0.802449804186 gnomAD-4.0.0 3.10039E-06 None None None None I None 4.01177E-05 0 None 0 0 None 0 0 1.69576E-06 0 0
E/A 25818 Ig-136 21 rs781425261 0.18 -0.301 0.999 N 0.679 0.559 0.49676076625 gnomAD-2.1.1 2.42E-05 None None None None N None 0 1.4529E-04 None 0 0 None 0 None 0 8.94E-06 0
E/A 25818 Ig-136 21 rs781425261 0.18 -0.301 0.999 N 0.679 0.559 0.49676076625 gnomAD-4.0.0 1.1145E-05 None None None None N None 0 1.37256E-04 None 0 0 None 0 0 2.85958E-06 0 0
E/K 25818 Ig-136 21 rs748619096 0.2401 -0.016 0.999 N 0.558 0.442 0.407082143382 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
E/K 25818 Ig-136 21 rs748619096 0.2401 -0.016 0.999 N 0.558 0.442 0.407082143382 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
E/K 25818 Ig-136 21 rs748619096 0.2401 -0.016 0.999 N 0.558 0.442 0.407082143382 gnomAD-4.0.0 1.61164E-05 None None None None N None 0 0 None 0 0 None 3.1251E-05 1.64636E-04 1.78029E-05 0 3.20318E-05
E/K 26214 Ig-137 22 rs944710014 0.3988 -0.119 0.977 N 0.581 0.46 0.378847511475 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
E/K 26214 Ig-137 22 rs944710014 0.3988 -0.119 0.977 N 0.581 0.46 0.378847511475 gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
E/K 26214 Ig-137 22 rs944710014 0.3988 -0.119 0.977 N 0.581 0.46 0.378847511475 gnomAD-4.0.0 4.33978E-06 None None None None N None 8.01218E-05 0 None 0 0 None 0 0 8.47823E-07 0 0
H/Y 26613 Ig-138 20 rs1276864550 0.0918 1.14 0.013 N 0.162 0.135 0.235038932564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
H/Y 26613 Ig-138 20 rs1276864550 0.0918 1.14 0.013 N 0.162 0.135 0.235038932564 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85876E-06 0 0
E/D 26900 Ig-139 21 rs751557221 0.1496 -0.694 0.02 N 0.225 0.172 0.321393169273 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/D 26900 Ig-139 21 rs751557221 0.1496 -0.694 0.02 N 0.225 0.172 0.321393169273 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.93573E-04 None 0 0 0 0 0
E/D 26900 Ig-139 21 rs751557221 0.1496 -0.694 0.02 N 0.225 0.172 0.321393169273 gnomAD-4.0.0 2.56345E-06 None None None None I None 0 0 None 0 2.42789E-05 None 0 0 0 0 2.84657E-05
F/C 27696 Ig-141 21 rs769398545 0.7714 -0.761 1.0 N 0.771 0.597 0.862818656922 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
F/C 27696 Ig-141 21 rs769398545 0.7714 -0.761 1.0 N 0.771 0.597 0.862818656922 gnomAD-4.0.0 4.1055E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.95604E-05 0
F/S 27696 Ig-141 21 rs769398545 0.8597 -1.919 1.0 N 0.774 0.524 0.8144640112 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
F/S 27696 Ig-141 21 rs769398545 0.8597 -1.919 1.0 N 0.774 0.524 0.8144640112 gnomAD-4.0.0 6.8425E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
N/K 28378 Ig-143 21 rs1575618109 0.2122 None 0.491 N 0.381 0.193 0.151104730317 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 28378 Ig-143 21 None 0.0645 None 0.166 N 0.429 0.167 0.134241683229 gnomAD-4.0.0 1.59115E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85806E-06 0 0
N/Y 28378 Ig-143 21 rs1165610195 0.1177 0.041 0.629 N 0.601 0.17 0.410204130746 gnomAD-4.0.0 5.47351E-06 None None None None I None 1.49388E-04 0 None 0 0 None 0 0 0 0 4.96936E-05
T/A 28775 Ig-144 21 rs1201545659 0.0869 -0.615 0.309 D 0.409 0.144 0.204665344411 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
T/A 28775 Ig-144 21 rs1201545659 0.0869 -0.615 0.309 D 0.409 0.144 0.204665344411 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/A 28775 Ig-144 21 rs1201545659 0.0869 -0.615 0.309 D 0.409 0.144 0.204665344411 gnomAD-4.0.0 6.57384E-06 None None None None I None 0 6.55394E-05 None 0 0 None 0 0 0 0 0
T/I 28775 Ig-144 21 None 0.1531 None 0.939 N 0.573 0.356 0.552900881131 gnomAD-4.0.0 2.05789E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69982E-06 0 0
D/N 29065 Ig-145 21 None 0.113 None 0.896 N 0.442 0.291 0.357929162469 gnomAD-4.0.0 1.36847E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79888E-06 0 0
R/T 29461 Ig-146 18 None 0.1499 None 0.801 N 0.505 0.269 0.388970301349 gnomAD-4.0.0 2.40067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62503E-06 0 0
F/L 30946 Ig-150 20 rs1462805478 0.8973 -0.778 0.826 N 0.425 0.21 0.646368640663 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
F/L 30946 Ig-150 20 rs1462805478 0.8973 -0.778 0.826 N 0.425 0.21 0.646368640663 gnomAD-4.0.0 1.36935E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79895E-06 0 0
F/V 30946 Ig-150 20 rs1462805478 0.4077 -1.1 0.959 N 0.451 0.288 0.761389543597 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
F/V 30946 Ig-150 20 rs1462805478 0.4077 -1.1 0.959 N 0.451 0.288 0.761389543597 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/V 30946 Ig-150 20 rs1462805478 0.4077 -1.1 0.959 N 0.451 0.288 0.761389543597 gnomAD-4.0.0 6.5722E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
D/E 31236 Ig-151 19 rs560835240 0.2573 -0.026 0.092 N 0.357 0.134 0.0884992946249 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 9.95E-05 0 None 0 None 0 0 0
D/E 31236 Ig-151 19 rs560835240 0.2573 -0.026 0.092 N 0.357 0.134 0.0884992946249 gnomAD-4.0.0 6.84202E-07 None None None None I None 0 0 None 3.82731E-05 0 None 0 0 0 0 0
D/N 31236 Ig-151 19 rs1697878797 0.1651 None 0.978 N 0.677 0.33 0.430923071578 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 31236 Ig-151 19 rs1697878797 0.1651 None 0.978 N 0.677 0.33 0.430923071578 gnomAD-4.0.0 6.57523E-06 None None None None I None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
D/G 31636 Ig-152 16 rs767187943 0.5741 -0.63 0.977 N 0.716 0.559 0.446715556694 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 1.1162E-04 None 0 None 0 0 0
D/G 31636 Ig-152 16 rs767187943 0.5741 -0.63 0.977 N 0.716 0.559 0.446715556694 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 3.85654E-04 None 0 0 0 0 0
D/G 31636 Ig-152 16 rs767187943 0.5741 -0.63 0.977 N 0.716 0.559 0.446715556694 gnomAD-4.0.0 3.71834E-06 None None None None I None 0 0 None 0 1.33755E-04 None 0 0 0 0 0
D/N 31636 Ig-152 16 rs776793953 0.3084 -0.019 0.993 N 0.673 0.363 0.371344866733 gnomAD-2.1.1 1.65199E-04 None None None None I None 0 0 None 0 0 None 1.34022E-03 None 0 0 0
D/N 31636 Ig-152 16 rs776793953 0.3084 -0.019 0.993 N 0.673 0.363 0.371344866733 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 0 6.20861E-04 0
D/N 31636 Ig-152 16 rs776793953 0.3084 -0.019 0.993 N 0.673 0.363 0.371344866733 gnomAD-4.0.0 7.49812E-05 None None None None I None 0 0 None 0 0 None 0 1.65235E-04 8.47639E-07 1.25167E-03 8.00256E-05
V/A 32327 Ig-154 21 None 0.1104 None None N 0.154 0.071 0.451023696535 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31889E-05 0
V/M 32327 Ig-154 21 rs956461857 0.1331 -0.325 0.73 N 0.405 0.101 0.571554507246 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
V/M 32327 Ig-154 21 rs956461857 0.1331 -0.325 0.73 N 0.405 0.101 0.571554507246 gnomAD-4.0.0 6.36519E-06 None None None None N None 0 0 None 0 0 None 0 0 8.5754E-06 0 3.02371E-05
T/N 32725 Ig-155 18 None 0.1239 None 0.004 N 0.299 0.145 0.269558022972 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
K/T 33616 Ig-159 21 None 0.9071 None 1.0 N 0.773 0.555 0.448696893172 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 34278 Ig-161 21 None 0.8146 None 0.999 N 0.817 0.449 0.703011581269 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
G/V 34278 Ig-161 21 rs3731752 0.5185 1.292 0.999 N 0.839 0.48 None gnomAD-2.1.1 3.93119E-02 None None None None N None 7.11038E-02 3.14056E-02 None 4.18196E-02 1.74613E-01 None 4.75786E-02 None 3.11775E-03 2.00044E-02 3.59944E-02
G/V 34278 Ig-161 21 rs3731752 0.5185 1.292 0.999 N 0.839 0.48 None gnomAD-3.1.2 4.09242E-02 None None None None N None 7.03725E-02 3.87485E-02 8.79121E-03 4.14747E-02 1.65056E-01 None 2.35716E-03 3.16456E-02 1.9803E-02 4.51907E-02 5.40153E-02
G/V 34278 Ig-161 21 rs3731752 0.5185 1.292 0.999 N 0.839 0.48 None 1000 genomes 7.80751E-02 None None None None N None 8.47E-02 4.03E-02 None None 1.716E-01 3.18E-02 None None None 4.7E-02 None
G/V 34278 Ig-161 21 rs3731752 0.5185 1.292 0.999 N 0.839 0.48 None gnomAD-4.0.0 2.92833E-02 None None None None N None 7.06209E-02 3.44563E-02 None 4.23534E-02 1.77092E-01 None 3.15625E-03 7.62125E-02 1.9895E-02 4.69059E-02 3.64882E-02
E/A 34383 Ig-162 21 None 0.8574 None 0.998 N 0.61 0.593 0.478222008075 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 34383 Ig-162 21 rs148525155 0.7696 -0.821 0.999 N 0.669 0.312 None gnomAD-2.1.1 3.79394E-03 None None None None I None 1.24008E-04 1.41515E-04 None 0 0 None 7.19566E-03 None 2.60542E-02 1.26622E-03 3.09336E-03
E/Q 34383 Ig-162 21 rs148525155 0.7696 -0.821 0.999 N 0.669 0.312 None gnomAD-3.1.2 2.74649E-03 None None None None I None 9.65E-05 1.3089E-04 0 0 0 None 2.68311E-02 0 1.39653E-03 5.99669E-03 1.43678E-03
E/Q 34383 Ig-162 21 rs148525155 0.7696 -0.821 0.999 N 0.669 0.312 None 1000 genomes 2.19649E-03 None None None None I None 0 0 None None 0 4E-03 None None None 7.2E-03 None
E/Q 34383 Ig-162 21 rs148525155 0.7696 -0.821 0.999 N 0.669 0.312 None gnomAD-4.0.0 2.39467E-03 None None None None I None 1.33252E-04 1.16651E-04 None 0 0 None 2.66735E-02 2.31099E-03 1.16399E-03 7.16984E-03 1.60077E-03
I/N 34962 Ig-163 21 rs746239963 0.8264 -1.103 0.988 N 0.589 0.439 0.778651688032 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
I/N 34962 Ig-163 21 rs746239963 0.8264 -1.103 0.988 N 0.589 0.439 0.778651688032 gnomAD-4.0.0 2.05242E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6982E-06 0 0
T/N 35304 Ig-165 19 None 0.1744 None 0.213 N 0.39 0.079 0.378148810121 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 35440 Ig-166 21 None 0.0818 None None N 0.197 0.129 0.0401082797425 gnomAD-4.0.0 1.5927E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86198E-06 0 0
A/V 35440 Ig-166 21 rs747111465 0.0913 0.727 None N 0.229 0.072 0.176091768786 gnomAD-2.1.1 2.81E-05 None None None None I None 0 2.03063E-04 None 0 0 None 0 None 0 0 0
A/V 35440 Ig-166 21 rs747111465 0.0913 0.727 None N 0.229 0.072 0.176091768786 gnomAD-4.0.0 1.11496E-05 None None None None I None 0 1.60095E-04 None 0 0 None 0 0 0 0 0
K/R 35627 Ig-167 21 rs1284079251 0.1272 None 0.003 N 0.254 0.085 0.309530620856 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/R 35627 Ig-167 21 rs1284079251 0.1272 None 0.003 N 0.254 0.085 0.309530620856 gnomAD-4.0.0 6.56935E-06 None None None None N None 2.41173E-05 0 None 0 0 None 0 0 0 0 0
T/P 35722 Ig-168 21 rs755302099 0.2266 -0.591 0.497 N 0.565 0.217 0.391156786388 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/P 35722 Ig-168 21 rs755302099 0.2266 -0.591 0.497 N 0.565 0.217 0.391156786388 gnomAD-4.0.0 1.59304E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86072E-06 0 0
T/S 35722 Ig-168 21 rs755302099 0.0728 None None N 0.239 0.084 0.228597637076 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/S 35722 Ig-168 21 rs755302099 0.0728 None None N 0.239 0.084 0.228597637076 gnomAD-4.0.0 6.56978E-06 None None None None N None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
A/V 35917 Ig-169 21 rs1439320895 0.7047 0.219 0.939 N 0.497 0.352 0.666169902468 gnomAD-2.1.1 4.03E-06 None None None -2.356(OBSL1) -0.856(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.88E-06 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.