Structural position:

  • Domain Type: Ig
  • Aligned Position: 4
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/K 9 Ig-1 4 rs146123323 0.0765 None None N 0.177 0.132 0.137902524267 gnomAD-3.1.2 6.57E-06 None None None -0.538(TCAP) N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
T/K 9 Ig-1 4 rs146123323 0.0765 None None N 0.177 0.132 0.137902524267 gnomAD-4.0.0 6.57134E-06 None None None -0.538(TCAP) N None 0 6.54279E-05 None 0 0 None 0 0 0 0 0
T/M 9 Ig-1 4 rs146123323 0.1146 0.106 0.552 D 0.297 0.14 None gnomAD-2.1.1 3.19E-05 None None None 0.352(TCAP) N None 1.84729E-04 5.78E-05 None 0 0 None 0 None 0 1.76E-05 1.63506E-04
T/M 9 Ig-1 4 rs146123323 0.1146 0.106 0.552 D 0.297 0.14 None gnomAD-3.1.2 2.63E-05 None None None 0.352(TCAP) N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
T/M 9 Ig-1 4 rs146123323 0.1146 0.106 0.552 D 0.297 0.14 None gnomAD-4.0.0 1.05341E-05 None None None 0.352(TCAP) N None 9.3423E-05 5.00017E-05 None 0 0 None 1.56191E-05 0 3.39007E-06 0 3.20195E-05
T/S 9 Ig-1 4 rs1298028827 0.139 -0.703 None N 0.123 0.08 0.199424873507 gnomAD-2.1.1 7.97E-06 None None None -0.478(TCAP) N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
T/S 9 Ig-1 4 rs1298028827 0.139 -0.703 None N 0.123 0.08 0.199424873507 gnomAD-4.0.0 2.73662E-06 None None None -0.478(TCAP) N None 0 0 None 0 0 None 0 0 3.59747E-06 0 0
V/F 107 Ig-2 4 None 0.1825 None 0.034 D 0.367 0.187 0.549290840505 gnomAD-4.0.0 6.86168E-07 None None None 0.209(TCAP) N None 0 0 None 0 0 None 0 0 9.01183E-07 0 0
V/I 107 Ig-2 4 rs755127321 0.0747 -0.266 None N 0.093 0.15 0.221019684889 gnomAD-2.1.1 1.62E-05 None None None -0.476(TCAP) N None 0 8.77E-05 None 0 0 None 0 None 0 8.96E-06 0
V/I 107 Ig-2 4 rs755127321 0.0747 -0.266 None N 0.093 0.15 0.221019684889 gnomAD-4.0.0 4.11701E-06 None None None -0.476(TCAP) N None 0 4.50005E-05 None 0 0 None 0 0 2.70355E-06 0 1.66174E-05
V/I 946 Ig-3 4 rs752246051 0.0962 -0.081 0.37 N 0.171 0.178 None gnomAD-2.1.1 1.77E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.88E-05 0
V/I 946 Ig-3 4 rs752246051 0.0962 -0.081 0.37 N 0.171 0.178 None gnomAD-3.1.2 6.59E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 946 Ig-3 4 rs752246051 0.0962 -0.081 0.37 N 0.171 0.178 None gnomAD-4.0.0 3.03764E-05 None None None None I None 0 0 None 0 0 None 0 0 4.15397E-05 0 0
I/F 1085 Ig-4 4 None 0.2665 None 0.317 N 0.325 0.146 0.33835085245 gnomAD-4.0.0 6.84076E-07 None None None None I None 0 0 None 0 0 None 0 0 8.993E-07 0 0
I/V 1085 Ig-4 4 rs2092854519 0.119 None None N 0.131 0.056 0.262662153117 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/V 1085 Ig-4 4 rs2092854519 0.119 None None N 0.131 0.056 0.262662153117 gnomAD-4.0.0 4.33709E-06 None None None None I None 0 1.66689E-05 None 0 0 None 0 0 4.23727E-06 0 1.60041E-05
D/A 1294 Ig-5 4 rs1233143011 0.1819 0.034 0.027 N 0.305 0.104 0.177238962908 gnomAD-2.1.1 1.2E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 0
D/A 1294 Ig-5 4 rs1233143011 0.1819 0.034 0.027 N 0.305 0.104 0.177238962908 gnomAD-4.0.0 3.42155E-06 None None None None I None 0 0 None 0 0 None 0 0 0 3.47866E-05 3.31356E-05
D/H 1294 Ig-5 4 None 0.2993 None 0.484 N 0.323 0.096 0.130388298395 gnomAD-4.0.0 6.84313E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99543E-07 0 0
V/L 1460 Ig-6 4 rs771127151 0.5118 0.01 0.997 N 0.477 0.453 0.580379909603 gnomAD-2.1.1 3.99E-06 None None None None I None 0 2.89E-05 None 0 0 None 0 None 0 0 0
V/L 1460 Ig-6 4 rs771127151 0.5118 0.01 0.997 N 0.477 0.453 0.580379909603 gnomAD-4.0.0 1.59074E-06 None None None None I None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
V/M 1460 Ig-6 4 rs771127151 0.5927 -0.318 1.0 D 0.638 0.429 0.675916937895 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.82E-06 0
V/M 1460 Ig-6 4 rs771127151 0.5927 -0.318 1.0 D 0.638 0.429 0.675916937895 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/M 1460 Ig-6 4 rs771127151 0.5927 -0.318 1.0 D 0.638 0.429 0.675916937895 gnomAD-4.0.0 6.40387E-06 None None None None I None 0 1.69469E-05 None 0 0 None 0 0 9.56869E-06 0 0
V/A 1559 Ig-7 4 rs1262171318 0.1331 None 0.822 N 0.391 0.135 0.516604699598 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78469E-04
V/A 1559 Ig-7 4 rs1262171318 0.1331 None 0.822 N 0.391 0.135 0.516604699598 gnomAD-4.0.0 3.09817E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54245E-06 0 3.20154E-05
V/G 1559 Ig-7 4 rs1262171318 0.2432 -0.936 0.971 D 0.753 0.43 0.68695168648 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/G 1559 Ig-7 4 rs1262171318 0.2432 -0.936 0.971 D 0.753 0.43 0.68695168648 gnomAD-4.0.0 6.84162E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
V/I 1559 Ig-7 4 rs538451328 0.0693 -0.145 0.014 N 0.188 0.049 0.259272394797 gnomAD-2.1.1 3.99E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
V/I 1559 Ig-7 4 rs538451328 0.0693 -0.145 0.014 N 0.188 0.049 0.259272394797 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 1559 Ig-7 4 rs538451328 0.0693 -0.145 0.014 N 0.188 0.049 0.259272394797 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
V/I 1559 Ig-7 4 rs538451328 0.0693 -0.145 0.014 N 0.188 0.049 0.259272394797 gnomAD-4.0.0 6.56625E-06 None None None None N None 2.40616E-05 0 None 0 0 None 0 0 0 0 0
K/E 1706 Ig-8 4 None 0.9604 None 0.996 N 0.575 0.464 0.48095081912 gnomAD-4.0.0 1.08029E-05 None None None None I None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
V/D 1844 Ig-9 4 None 0.9082 None 1.0 D 0.783 0.626 0.841589584418 gnomAD-4.0.0 1.59103E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85667E-06 0 0
V/F 1844 Ig-9 4 rs769474668 0.4213 -0.824 1.0 D 0.714 0.548 0.793992609473 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 4.65E-05 0 0
V/F 1844 Ig-9 4 rs769474668 0.4213 -0.824 1.0 D 0.714 0.548 0.793992609473 gnomAD-3.1.2 3.29E-05 None None None None I None 0 0 0 0 0 None 9.42E-05 0 5.88E-05 0 0
V/F 1844 Ig-9 4 rs769474668 0.4213 -0.824 1.0 D 0.714 0.548 0.793992609473 gnomAD-4.0.0 1.73501E-05 None None None None I None 0 0 None 0 0 None 1.56666E-05 0 2.20339E-05 0 1.60036E-05
F/L 2081 Ig-10 4 None 0.8061 None None N 0.103 0.162 0.0846915920261 gnomAD-4.0.0 6.84087E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99302E-07 0 0
T/I 2177 Ig-11 4 None 0.1141 None 0.018 N 0.266 0.298 0.405700215632 gnomAD-4.0.0 2.05244E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79866E-06 1.15931E-05 0
L/P 2359 Ig-13 4 None 0.8618 None 0.999 D 0.626 0.871 0.911129948677 gnomAD-4.0.0 2.40064E-06 None None None None I None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
I/V 2448 Ig-14 4 rs143616825 0.0787 -0.69 None N 0.088 0.074 None gnomAD-2.1.1 7.98E-06 None None None None I None 0 5.79E-05 None 0 0 None 0 None 0 0 0
I/V 2448 Ig-14 4 rs143616825 0.0787 -0.69 None N 0.088 0.074 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 2.61883E-04 0 0 0 None 0 0 0 0 0
I/V 2448 Ig-14 4 rs143616825 0.0787 -0.69 None N 0.088 0.074 None 1000 genomes 3.99361E-04 None None None None I None 0 2.9E-03 None None 0 0 None None None 0 None
I/V 2448 Ig-14 4 rs143616825 0.0787 -0.69 None N 0.088 0.074 None gnomAD-4.0.0 1.28041E-05 None None None None I None 0 1.18608E-04 None 0 0 None 0 0 4.78364E-06 0 2.84026E-05
I/M 2536 Ig-15 4 None 0.1307 None 0.942 D 0.481 0.232 0.466991082792 gnomAD-4.0.0 6.84141E-07 None None None None I None 0 0 None 0 0 None 0 1.73611E-04 0 0 0
I/S 2536 Ig-15 4 None 0.3206 None 0.942 N 0.569 0.342 0.67300728461 gnomAD-4.0.0 1.59086E-06 None None None None I None 5.65419E-05 0 None 0 0 None 0 0 0 0 0
I/L 2798 Ig-18 4 None 0.2463 None 0.031 N 0.093 0.128 0.28722502521 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 2798 Ig-18 4 rs751135365 0.6939 -0.533 0.961 N 0.521 0.36 0.515938915144 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.85E-06 0
I/T 2798 Ig-18 4 rs751135365 0.6939 -0.533 0.961 N 0.521 0.36 0.515938915144 gnomAD-4.0.0 1.36813E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79857E-06 0 0
T/I 2885 Ig-19 4 rs756258905 0.3079 0.172 0.992 N 0.608 0.508 None gnomAD-2.1.1 2.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.18E-05 0
T/I 2885 Ig-19 4 rs756258905 0.3079 0.172 0.992 N 0.608 0.508 None gnomAD-4.0.0 2.70398E-05 None None None None N None 0 0 None 0 0 None 0 0 4.28483E-05 0 6.04303E-05
T/A 2972 Ig-20 4 None 0.2414 None 0.999 N 0.463 0.422 0.281780670237 gnomAD-4.0.0 2.05265E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69793E-06 0 0
T/I 2972 Ig-20 4 rs1244469362 0.3 None 1.0 N 0.71 0.538 0.453962894745 gnomAD-4.0.0 2.05265E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79863E-06 1.15937E-05 0
T/S 2972 Ig-20 4 rs2091002766 0.2854 None 0.999 N 0.465 0.307 0.260249123532 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/S 2972 Ig-20 4 rs2091002766 0.2854 None 0.999 N 0.465 0.307 0.260249123532 gnomAD-4.0.0 6.57056E-06 None None None None N None 2.41278E-05 0 None 0 0 None 0 0 0 0 0
R/G 3061 Ig-21 4 rs561375563 0.8998 -0.59 0.959 D 0.442 0.498 0.664136802156 gnomAD-2.1.1 3.99E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
R/G 3061 Ig-21 4 rs561375563 0.8998 -0.59 0.959 D 0.442 0.498 0.664136802156 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/G 3061 Ig-21 4 rs561375563 0.8998 -0.59 0.959 D 0.442 0.498 0.664136802156 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/G 3061 Ig-21 4 rs561375563 0.8998 -0.59 0.959 D 0.442 0.498 0.664136802156 gnomAD-4.0.0 6.56426E-06 None None None None N None 2.40535E-05 0 None 0 0 None 0 0 0 0 0
R/S 3061 Ig-21 4 rs773298764 0.9561 -0.295 0.852 N 0.439 0.388 0.318252033908 gnomAD-4.0.0 1.59071E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85657E-06 0 0
R/G 3150 Ig-22 4 rs146572907 0.6046 -0.492 0.911 N 0.305 0.432 0.574021187364 gnomAD-2.1.1 3.98E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
R/G 3150 Ig-22 4 rs146572907 0.6046 -0.492 0.911 N 0.305 0.432 0.574021187364 gnomAD-4.0.0 6.84087E-07 None None None None N None 2.98686E-05 0 None 0 0 None 0 0 0 0 0
R/L 3150 Ig-22 4 None 0.5077 None 0.837 N 0.301 0.399 0.550293681976 gnomAD-4.0.0 6.84079E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99302E-07 0 0
R/Q 3150 Ig-22 4 rs141093658 0.1807 0.151 0.958 N 0.331 0.258 None gnomAD-2.1.1 2.83E-05 None None None None N None 4.01E-05 2.82E-05 None 9.66E-05 0 None 0 None 0 2.33E-05 2.77393E-04
R/Q 3150 Ig-22 4 rs141093658 0.1807 0.151 0.958 N 0.331 0.258 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 3150 Ig-22 4 rs141093658 0.1807 0.151 0.958 N 0.331 0.258 None gnomAD-4.0.0 2.47831E-05 None None None None N None 4.00384E-05 3.33311E-05 None 6.75539E-05 0 None 1.56265E-05 0 2.20338E-05 0 9.60215E-05
L/Q 3242 Ig-23 4 rs2090060609 0.1433 None 0.99 D 0.634 0.57 0.854039639294 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/Q 3242 Ig-23 4 rs2090060609 0.1433 None 0.99 D 0.634 0.57 0.854039639294 gnomAD-4.0.0 6.56927E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
I/S 3348 Ig-24 4 None 0.3527 None 0.062 N 0.314 0.231 0.722308813073 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
F/L 3663 Ig-26 4 rs777956268 0.1565 -0.712 None None None 0.087 None gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
F/L 3663 Ig-26 4 rs777956268 0.1565 -0.712 None None None 0.087 None gnomAD-4.0.0 1.59129E-05 None None None None I None 0 0 None 0 0 None 0 0 2.85814E-05 0 0
I/F 3823 Ig-27 4 rs1233837931 0.1554 -0.561 0.175 D 0.241 0.233 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/F 3823 Ig-27 4 rs1233837931 0.1554 -0.561 0.175 D 0.241 0.233 None gnomAD-4.0.0 1.59176E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85879E-06 0 0
L/H 3941 Ig-28 4 None 0.156 None 0.822 N 0.259 0.125 None gnomAD-4.0.0 1.5911E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85791E-06 0 0
K/Q 4703 Ig-30 4 rs1479181903 0.123 0.064 0.117 N 0.318 0.133 0.12205267543 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
K/Q 4703 Ig-30 4 rs1479181903 0.123 0.064 0.117 N 0.318 0.133 0.12205267543 gnomAD-4.0.0 1.59553E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86763E-06 0 0
L/F 4798 Ig-31 4 rs2081388048 0.0714 None None D 0.152 0.235 0.287603790349 gnomAD-4.0.0 1.65128E-06 None None None None I None 0 0 None 0 0 None 0 0 2.95412E-06 0 0
L/P 4798 Ig-31 4 None 0.6036 None None D 0.283 0.233 0.479818277033 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
I/L 4891 Ig-32 4 rs1304712343 0.1212 None 0.267 N 0.173 0.072 0.419835214384 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/L 4891 Ig-32 4 rs1304712343 0.1212 None 0.267 N 0.173 0.072 0.419835214384 gnomAD-4.0.0 6.56996E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46972E-05 0 0
I/S 4891 Ig-32 4 None 0.3339 None 0.136 N 0.183 0.154 0.51081628273 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 4984 Ig-33 4 rs903648091 0.1301 -0.312 0.997 N 0.404 0.229 0.286081765059 gnomAD-4.0.0 1.397E-05 None None None None N None 1.21847E-04 2.50238E-05 None 0 5.15783E-05 None 0 1.75809E-04 1.09622E-05 0 0
V/L 5171 Ig-35 4 rs776104290 0.1467 -0.126 0.002 N 0.073 0.095 0.207176502487 gnomAD-2.1.1 4.13E-06 None None None None N None 0 3E-05 None 0 0 None 0 None 0 0 0
V/L 5171 Ig-35 4 rs776104290 0.1467 -0.126 0.002 N 0.073 0.095 0.207176502487 gnomAD-4.0.0 1.63143E-06 None None None None N None 0 2.34478E-05 None 0 0 None 0 0 0 0 0
I/L 5264 Ig-36 4 None 0.0778 None None N 0.096 0.054 0.235664433957 gnomAD-4.0.0 1.59992E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.04099E-05
I/T 5264 Ig-36 4 rs768858900 0.0564 -1.107 None N 0.197 0.093 0.377976839388 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 6.59E-05 None 0 0 0
I/T 5264 Ig-36 4 rs768858900 0.0564 -1.107 None N 0.197 0.093 0.377976839388 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
I/T 5264 Ig-36 4 rs768858900 0.0564 -1.107 None N 0.197 0.093 0.377976839388 gnomAD-4.0.0 5.58835E-06 None None None None N None 0 1.67269E-05 None 0 0 None 0 0 2.54765E-06 5.50237E-05 0
I/V 5264 Ig-36 4 None 0.0622 None None N 0.111 0.061 0.184867976434 gnomAD-4.0.0 1.59992E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87778E-06 0 0
T/A 5360 Ig-37 4 rs749081117 0.1011 -0.621 0.998 N 0.374 0.256 0.139678290688 gnomAD-2.1.1 3.35E-05 None None None None N None 0 2.63143E-04 None 0 0 None 0 None 0 0 0
T/A 5360 Ig-37 4 rs749081117 0.1011 -0.621 0.998 N 0.374 0.256 0.139678290688 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/A 5360 Ig-37 4 rs749081117 0.1011 -0.621 0.998 N 0.374 0.256 0.139678290688 gnomAD-4.0.0 5.00678E-06 None None None None N None 0 1.36101E-04 None 0 0 None 0 0 0 0 0
V/G 5546 Ig-39 4 rs903298127 0.1525 None 0.117 N 0.285 0.215 0.654939258183 gnomAD-4.0.0 1.62235E-06 None None None None N None 0 0 None 0 0 None 0 0 2.91455E-06 0 0
V/I 5546 Ig-39 4 rs2154310117 0.0624 None None N 0.135 0.06 0.110078149338 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/S 5640 Ig-40 4 rs2080609627 0.091 None None N 0.075 0.116 0.124217242631 gnomAD-4.0.0 5.50119E-06 None None None None I None 0 0 None 0 0 None 0 0 7.23117E-06 0 0
I/M 5733 Ig-41 4 rs1161139503 0.0848 -0.36 0.033 N 0.254 0.026 0.101711395817 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.11E-06 0
I/M 5733 Ig-41 4 rs1161139503 0.0848 -0.36 0.033 N 0.254 0.026 0.101711395817 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 5733 Ig-41 4 rs1161139503 0.0848 -0.36 0.033 N 0.254 0.026 0.101711395817 gnomAD-4.0.0 4.3621E-06 None None None None N None 0 0 None 0 0 None 0 0 5.95974E-06 0 0
I/V 5733 Ig-41 4 rs2080510876 0.0655 None None N 0.029 0.06 0.148003135375 gnomAD-4.0.0 3.22961E-06 None None None None N None 0 0 None 0 0 None 0 0 2.9025E-06 1.45484E-05 0
T/I 5826 Ig-42 4 None 0.094 None None N 0.189 0.079 0.0401082797425 gnomAD-4.0.0 1.5927E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02572E-05
V/M 6015 Ig-44 4 rs753892185 0.1231 -0.235 0.004 N 0.203 0.037 0.141422826196 gnomAD-2.1.1 4.23E-06 None None None None N None 0 0 None 0 0 None 3.53E-05 None 0 0 0
V/M 6015 Ig-44 4 rs753892185 0.1231 -0.235 0.004 N 0.203 0.037 0.141422826196 gnomAD-4.0.0 1.37766E-06 None None None None N None 3.01296E-05 0 None 0 0 None 0 0 0 1.1836E-05 0
I/M 6202 Ig-46 4 rs1041345186 0.0899 None 0.019 N 0.179 0.069 0.304108284078 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 6202 Ig-46 4 rs1041345186 0.0899 None 0.019 N 0.179 0.069 0.304108284078 gnomAD-4.0.0 6.57324E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47037E-05 0 0
I/N 6202 Ig-46 4 None 0.1429 None 0.427 N 0.375 0.163 0.687687559846 gnomAD-4.0.0 6.84698E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99981E-07 0 0
I/T 6202 Ig-46 4 rs1298665270 0.1078 -0.128 0.096 N 0.27 0.116 0.405150804464 gnomAD-2.1.1 8.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/T 6202 Ig-46 4 rs1298665270 0.1078 -0.128 0.096 N 0.27 0.116 0.405150804464 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 0 4.78011E-04
I/T 6202 Ig-46 4 rs1298665270 0.1078 -0.128 0.096 N 0.27 0.116 0.405150804464 gnomAD-4.0.0 6.20091E-06 None None None None I None 0 1.67001E-05 None 0 0 None 0 0 5.0884E-06 0 4.80769E-05
I/V 6202 Ig-46 4 None 0.07 None None N 0.115 0.066 0.262175524916 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 6295 Ig-47 4 None 0.073 None None N 0.056 0.117 0.0920862733494 gnomAD-4.0.0 3.34191E-06 None None None None I None 0 0 None 0 0 None 0 0 5.95948E-06 0 0
V/I 6388 Ig-48 4 rs550617268 0.0538 -0.233 None N 0.079 0.03 0.154104182512 gnomAD-2.1.1 4.69E-05 None None None None N None 0 0 None 0 1.5402E-04 None 3.36E-05 None 0 6.3E-05 1.42126E-04
V/I 6388 Ig-48 4 rs550617268 0.0538 -0.233 None N 0.079 0.03 0.154104182512 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.56E-05 0 0 3.861E-04 None 0 0 1.47E-05 0 0
V/I 6388 Ig-48 4 rs550617268 0.0538 -0.233 None N 0.079 0.03 0.154104182512 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
V/I 6388 Ig-48 4 rs550617268 0.0538 -0.233 None N 0.079 0.03 0.154104182512 gnomAD-4.0.0 4.18776E-05 None None None None N None 1.33822E-05 5.03592E-05 None 0 1.1239E-04 None 0 0 4.4486E-05 0 9.70434E-05
V/L 6388 Ig-48 4 None 0.0785 None None N 0.076 0.043 0.136095386433 gnomAD-4.0.0 6.90765E-07 None None None None N None 0 0 None 0 0 None 0 0 9.08349E-07 0 0
T/A 6484 Ig-49 4 rs1425867664 0.1233 -0.585 0.78 N 0.379 0.16 0.117506650769 gnomAD-2.1.1 4.28E-06 None None None None N None 0 0 None 0 5.82E-05 None 0 None 0 0 0
T/A 6484 Ig-49 4 rs1425867664 0.1233 -0.585 0.78 N 0.379 0.16 0.117506650769 gnomAD-4.0.0 1.62217E-06 None None None None N None 0 0 None 0 2.79189E-05 None 0 0 0 0 0
V/A 6670 Ig-51 4 None 0.2155 None 0.003 N 0.101 0.144 0.300449992093 gnomAD-4.0.0 2.07413E-06 None None None None N None 0 0 None 0 0 None 0 0 9.05413E-07 2.3955E-05 0
V/I 6670 Ig-51 4 rs749601124 0.0766 -0.185 0.008 N 0.169 0.052 0.24896430686 gnomAD-2.1.1 4.26E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.31E-06 0
V/I 6670 Ig-51 4 rs749601124 0.0766 -0.185 0.008 N 0.169 0.052 0.24896430686 gnomAD-4.0.0 1.38357E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81148E-06 0 0
S/I 6764 Ig-52 4 None 0.1034 None 0.007 N 0.199 0.173 0.461144880706 gnomAD-4.0.0 1.86695E-06 None None None None I None 0 0 None 0 0 None 0 0 3.30192E-06 0 0
S/N 6764 Ig-52 4 rs1030649234 0.1152 None 0.351 N 0.235 0.131 0.166414681773 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 6764 Ig-52 4 rs1030649234 0.1152 None 0.351 N 0.235 0.131 0.166414681773 gnomAD-4.0.0 6.57479E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47033E-05 0 0
S/R 6764 Ig-52 4 None 0.2409 None 0.655 N 0.372 0.201 0.317378411342 gnomAD-4.0.0 7.30962E-07 None None None None I None 0 3.21337E-05 None 0 0 None 0 0 0 0 0
V/D 6951 Ig-54 4 rs1578062152 0.3541 None 0.484 N 0.42 0.219 0.710221506454 gnomAD-4.0.0 2.07849E-06 None None None None N None 0 0 None 0 0 None 0 0 2.72752E-06 0 0
V/I 6951 Ig-54 4 rs907454028 0.0725 -0.014 None N 0.119 0.074 0.300110245524 gnomAD-2.1.1 4.17E-06 None None None None N None 6.52E-05 0 None 0 0 None 0 None 0 0 0
V/I 6951 Ig-54 4 rs907454028 0.0725 -0.014 None N 0.119 0.074 0.300110245524 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 6951 Ig-54 4 rs907454028 0.0725 -0.014 None N 0.119 0.074 0.300110245524 gnomAD-4.0.0 3.93788E-06 None None None None N None 1.71004E-05 1.73925E-05 None 0 0 None 0 0 2.46488E-06 0 0
L/F 7233 Ig-57 4 rs370679926 0.0904 None 0.055 N 0.218 0.136 0.374434639691 gnomAD-4.0.0 1.37052E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80061E-06 0 0
L/M 7233 Ig-57 4 None 0.0808 None 0.001 N 0.126 0.103 0.400899426204 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 7422 Ig-59 4 None 0.3445 None 0.026 N 0.189 0.276 0.293147016451 gnomAD-4.0.0 1.37003E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80056E-06 0 0
A/S 7422 Ig-59 4 None 0.0933 None 0.233 N 0.443 0.224 0.200317383148 gnomAD-4.0.0 6.85015E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00278E-07 0 0
A/T 7422 Ig-59 4 rs2078575332 0.1028 None 0.069 N 0.099 0.271 0.19670166235 gnomAD-4.0.0 1.37003E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80056E-06 0 0
D/E 7518 Ig-60 4 None 0.7169 None 0.98 N 0.348 0.151 0.218112801441 gnomAD-4.0.0 1.69609E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.59944E-05 0
D/V 7518 Ig-60 4 rs749008105 0.7587 0.544 1.0 N 0.737 0.36 0.312001716656 gnomAD-2.1.1 1.85E-05 None None None None I None 0 7.14E-05 None 0 0 None 8.83E-05 None 0 0 0
D/V 7518 Ig-60 4 rs749008105 0.7587 0.544 1.0 N 0.737 0.36 0.312001716656 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
D/V 7518 Ig-60 4 rs749008105 0.7587 0.544 1.0 N 0.737 0.36 0.312001716656 gnomAD-4.0.0 1.08031E-05 None None None None I None 0 3.78172E-05 None 0 0 None 0 0 0 8.9315E-05 0
V/I 7611 Ig-61 4 rs2078303189 0.0707 None None N 0.113 0.119 0.204665344411 gnomAD-4.0.0 1.63227E-06 None None None None N None 0 0 None 0 0 None 0 0 2.94507E-06 0 0
V/L 7611 Ig-61 4 None 0.2107 None 0.02 N 0.345 0.108 0.283371740733 gnomAD-4.0.0 1.63227E-06 None None None None N None 0 0 None 0 0 None 0 0 2.94507E-06 0 0
T/I 7705 Ig-62 4 rs772162626 0.0784 0.137 None N 0.141 0.037 0.0297737177859 gnomAD-2.1.1 3.1E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.65E-05 0
T/I 7705 Ig-62 4 rs772162626 0.0784 0.137 None N 0.141 0.037 0.0297737177859 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 7705 Ig-62 4 rs772162626 0.0784 0.137 None N 0.141 0.037 0.0297737177859 gnomAD-4.0.0 1.00511E-05 None None None None I None 0 0 None 0 0 None 0 0 1.10953E-05 0 4.88361E-05
T/S 7705 Ig-62 4 rs772162626 0.0921 None None N 0.068 0.084 0.0762999501168 gnomAD-3.1.2 1.32E-05 None None None None I None 0 1.31165E-04 0 0 0 None 0 0 0 0 0
T/S 7705 Ig-62 4 rs772162626 0.0921 None None N 0.068 0.084 0.0762999501168 gnomAD-4.0.0 2.51278E-06 None None None None I None 0 5.37461E-05 None 0 0 None 0 0 8.53486E-07 0 0
V/L 7798 Ig-63 4 rs144032104 0.1817 -0.459 0.362 N 0.392 0.076 0.20549828249 gnomAD-4.0.0 4.1165E-06 None None None None I None 0 0 None 0 0 None 0 0 5.40926E-06 0 0
V/M 7798 Ig-63 4 rs144032104 0.1902 -0.449 0.997 N 0.461 0.176 None gnomAD-2.1.1 4.07E-05 None None None None I None 1.29584E-04 0 None 0 0 None 1.33842E-04 None 0 3.6E-05 0
V/M 7798 Ig-63 4 rs144032104 0.1902 -0.449 0.997 N 0.461 0.176 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
V/M 7798 Ig-63 4 rs144032104 0.1902 -0.449 0.997 N 0.461 0.176 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
V/M 7798 Ig-63 4 rs144032104 0.1902 -0.449 0.997 N 0.461 0.176 None gnomAD-4.0.0 1.92576E-05 None None None None I None 0 0 None 0 0 None 0 0 2.03872E-05 6.63042E-05 1.60488E-05
I/L 7892 Ig-64 4 None 0.0937 None None N 0.097 0.075 0.152612264143 gnomAD-4.0.0 6.88564E-07 None None None None N None 0 0 None 0 0 None 0 0 9.03674E-07 0 0
I/R 7892 Ig-64 4 rs201181445 0.1694 0.202 0.171 N 0.388 0.097 0.418718287753 gnomAD-2.1.1 1.63E-05 None None None None N None 1.29887E-04 5.88E-05 None 0 0 None 0 None 0 0 0
I/R 7892 Ig-64 4 rs201181445 0.1694 0.202 0.171 N 0.388 0.097 0.418718287753 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 1.31199E-04 0 0 0 None 0 0 0 0 0
I/R 7892 Ig-64 4 rs201181445 0.1694 0.202 0.171 N 0.388 0.097 0.418718287753 gnomAD-4.0.0 9.94737E-06 None None None None N None 4.01531E-05 8.3949E-05 None 0 0 None 0 0 4.24999E-06 0 4.82393E-05
I/T 7892 Ig-64 4 rs201181445 0.065 -0.699 None N 0.131 0.072 None gnomAD-2.1.1 9.42E-05 None None None None N None 1.24399E-04 2.87E-05 None 0 0 None 0 None 7.62807E-04 2.39E-05 0
I/T 7892 Ig-64 4 rs201181445 0.065 -0.699 None N 0.131 0.072 None gnomAD-3.1.2 7.23E-05 None None None None N None 7.24E-05 0 0 0 0 None 5.65078E-04 0 2.94E-05 0 0
I/T 7892 Ig-64 4 rs201181445 0.065 -0.699 None N 0.131 0.072 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
I/T 7892 Ig-64 4 rs201181445 0.065 -0.699 None N 0.131 0.072 None gnomAD-4.0.0 7.45998E-05 None None None None N None 8.01753E-05 1.67842E-05 None 0 0 None 6.25723E-04 0 6.12002E-05 0 1.60741E-05
I/V 7892 Ig-64 4 rs2078060561 0.0666 None None N 0.102 0.08 0.128392430309 gnomAD-4.0.0 2.06569E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.53582E-05 0
I/T 7988 Ig-65 4 rs1481820577 0.1127 -0.478 0.001 N 0.143 0.169 0.352262096564 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
I/T 7988 Ig-65 4 rs1481820577 0.1127 -0.478 0.001 N 0.143 0.169 0.352262096564 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 7988 Ig-65 4 rs1481820577 0.1127 -0.478 0.001 N 0.143 0.169 0.352262096564 gnomAD-4.0.0 2.05215E-05 None None None None N None 0 0 None 0 0 None 0 0 3.59548E-05 0 2.84592E-05
I/V 7988 Ig-65 4 None 0.0758 None None N 0.123 0.044 0.221019684889 gnomAD-4.0.0 3.18667E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72741E-06 0 0
V/M 8174 Ig-67 4 rs727504961 0.1596 None 0.454 N 0.276 0.219 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 8174 Ig-67 4 rs727504961 0.1596 None 0.454 N 0.276 0.219 None gnomAD-4.0.0 3.10159E-06 None None None None N None 0 0 None 0 0 None 0 0 4.24185E-06 0 0
I/F 8267 Ig-68 4 rs534974639 0.2149 -0.791 0.453 N 0.281 0.189 0.446510307777 gnomAD-2.1.1 8.33E-06 None None None None N None 1.29938E-04 0 None 0 0 None 0 None 0 0 0
I/F 8267 Ig-68 4 rs534974639 0.2149 -0.791 0.453 N 0.281 0.189 0.446510307777 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
I/F 8267 Ig-68 4 rs534974639 0.2149 -0.791 0.453 N 0.281 0.189 0.446510307777 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
I/F 8267 Ig-68 4 rs534974639 0.2149 -0.791 0.453 N 0.281 0.189 0.446510307777 gnomAD-4.0.0 6.87145E-06 None None None None N None 1.47035E-04 0 None 0 0 None 0 0 0 0 0
I/T 8267 Ig-68 4 None 0.0884 None 0.002 N 0.109 0.073 0.359357374593 gnomAD-4.0.0 1.62361E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44513E-05 0
A/E 8363 Ig-69 4 rs778129279 0.4067 -0.562 0.907 N 0.325 0.387 0.504052602331 gnomAD-2.1.1 4.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.14E-06 0
A/E 8363 Ig-69 4 rs778129279 0.4067 -0.562 0.907 N 0.325 0.387 0.504052602331 gnomAD-4.0.0 3.21451E-06 None None None None N None 5.78972E-05 0 None 0 0 None 0 0 2.88361E-06 0 0
A/G 8363 Ig-69 4 rs778129279 0.176 -0.795 0.404 N 0.216 0.288 0.306695030598 gnomAD-2.1.1 4.12E-06 None None None None N None 0 0 None 0 5.66E-05 None 0 None 0 0 0
A/G 8363 Ig-69 4 rs778129279 0.176 -0.795 0.404 N 0.216 0.288 0.306695030598 gnomAD-4.0.0 1.60726E-06 None None None None N None 0 0 None 0 2.78009E-05 None 0 0 0 0 0
A/P 8363 Ig-69 4 rs200972189 0.2573 -0.185 0.021 N 0.148 0.311 None gnomAD-2.1.1 1.1E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.4E-05 0
A/P 8363 Ig-69 4 rs200972189 0.2573 -0.185 0.021 N 0.148 0.311 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
A/P 8363 Ig-69 4 rs200972189 0.2573 -0.185 0.021 N 0.148 0.311 None gnomAD-4.0.0 1.49324E-05 None None None None N None 0 0 None 0 0 None 0 1.66058E-04 1.95479E-05 0 0
A/S 8363 Ig-69 4 rs200972189 0.0895 -0.77 0.02 N 0.127 0.221 None gnomAD-2.1.1 2.44767E-04 None None None None N None 2.26036E-03 3.47162E-04 None 0 0 None 0 None 0 0 1.44676E-04
A/S 8363 Ig-69 4 rs200972189 0.0895 -0.77 0.02 N 0.127 0.221 None gnomAD-3.1.2 7.89038E-04 None None None None N None 2.58342E-03 6.55136E-04 0 0 0 None 0 0 1.47E-05 0 9.56938E-04
A/S 8363 Ig-69 4 rs200972189 0.0895 -0.77 0.02 N 0.127 0.221 None 1000 genomes 9.98403E-04 None None None None N None 3.8E-03 0 None None 0 0 None None None 0 None
A/S 8363 Ig-69 4 rs200972189 0.0895 -0.77 0.02 N 0.127 0.221 None gnomAD-4.0.0 1.41847E-04 None None None None N None 2.45315E-03 4.0505E-04 None 0 0 None 0 0 2.54975E-06 0 2.8965E-04
A/V 8363 Ig-69 4 None 0.1446 None 0.116 N 0.14 0.251 0.346992582518 gnomAD-4.0.0 1.60726E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88361E-06 0 0
I/T 8552 Ig-71 4 rs940884256 0.2919 -0.629 0.003 N 0.135 0.213 0.379020345274 gnomAD-2.1.1 5E-06 None None None None N None 8.43E-05 0 None 0 0 None 0 None 0 0 0
I/T 8552 Ig-71 4 rs940884256 0.2919 -0.629 0.003 N 0.135 0.213 0.379020345274 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
I/T 8552 Ig-71 4 rs940884256 0.2919 -0.629 0.003 N 0.135 0.213 0.379020345274 gnomAD-4.0.0 5.05384E-06 None None None None N None 9.42177E-05 0 None 0 0 None 0 0 0 0 1.63068E-05
R/C 8646 Ig-72 4 rs72648987 0.0884 -0.197 0.001 N 0.207 0.084 None gnomAD-2.1.1 1.65369E-02 None None None None I None 3.87565E-03 1.41441E-02 None 1.25052E-02 1.04998E-04 None 1.49592E-02 None 2.11205E-02 2.17043E-02 1.96136E-02
R/C 8646 Ig-72 4 rs72648987 0.0884 -0.197 0.001 N 0.207 0.084 None gnomAD-3.1.2 1.65713E-02 None None None None I None 4.66116E-03 2.50492E-02 3.28947E-03 1.09447E-02 1.9305E-04 None 2.10576E-02 1.89873E-02 2.28282E-02 1.66182E-02 1.96737E-02
R/C 8646 Ig-72 4 rs72648987 0.0884 -0.197 0.001 N 0.207 0.084 None 1000 genomes 9.38498E-03 None None None None I None 0 1.59E-02 None None 0 2.58E-02 None None None 1.02E-02 None
R/C 8646 Ig-72 4 rs72648987 0.0884 -0.197 0.001 N 0.207 0.084 None gnomAD-4.0.0 1.88575E-02 None None None None I None 4.02813E-03 1.75393E-02 None 1.19703E-02 8.94334E-05 None 2.25869E-02 1.83596E-02 2.0923E-02 1.49913E-02 1.7455E-02
R/H 8646 Ig-72 4 rs144587343 0.0706 -0.836 None N 0.142 0.06 None gnomAD-2.1.1 7.37E-05 None None None None I None 4.16458E-04 2.99E-05 None 0 0 None 1.41064E-04 None 0 3.2E-05 1.46284E-04
R/H 8646 Ig-72 4 rs144587343 0.0706 -0.836 None N 0.142 0.06 None gnomAD-3.1.2 1.64619E-04 None None None None I None 3.87203E-04 1.3113E-04 0 0 0 None 0 0 7.36E-05 2.07469E-04 4.79846E-04
R/H 8646 Ig-72 4 rs144587343 0.0706 -0.836 None N 0.142 0.06 None 1000 genomes 3.99361E-04 None None None None I None 1.5E-03 0 None None 0 0 None None None 0 None
R/H 8646 Ig-72 4 rs144587343 0.0706 -0.836 None N 0.142 0.06 None gnomAD-4.0.0 1.07994E-04 None None None None I None 4.31034E-04 6.88373E-05 None 0 2.23444E-05 None 0 0 1.03867E-04 7.88555E-05 1.13129E-04
R/L 8646 Ig-72 4 rs144587343 0.1017 None None N 0.089 0.078 0.144782658237 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
R/L 8646 Ig-72 4 rs144587343 0.1017 None None N 0.089 0.078 0.144782658237 gnomAD-4.0.0 1.24858E-06 None None None None I None 0 1.72153E-05 None 0 0 None 0 0 8.51362E-07 0 0
V/L 8739 Ig-73 4 None 0.1135 None None N 0.119 0.073 0.226586394389 gnomAD-4.0.0 1.61987E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.07012E-05
V/L 8833 Ig-74 4 rs1316360664 0.1092 -0.213 0.001 N 0.069 0.09 0.141422826196 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.39E-05 None 0 0 0
V/A 9208 Ig-78 4 rs753893157 0.2946 -1.189 0.051 N 0.09 0.091 0.408036853922 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 1.63945E-04 None 0 0 0
V/A 9208 Ig-78 4 rs753893157 0.2946 -1.189 0.051 N 0.09 0.091 0.408036853922 gnomAD-4.0.0 1.36895E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.32072E-04 0
V/I 9208 Ig-78 4 None 0.0705 None 0.005 N 0.101 0.093 0.276482976112 gnomAD-4.0.0 6.84525E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99826E-07 0 0
V/L 9208 Ig-78 4 rs761956896 0.1514 -0.175 0.005 N 0.069 0.105 0.197625483188 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/L 9208 Ig-78 4 rs761956896 0.1514 -0.175 0.005 N 0.069 0.105 0.197625483188 gnomAD-4.0.0 1.36905E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79965E-06 0 0
S/P 9304 Ig-79 4 rs186512181 0.1554 None None N 0.129 0.258 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
S/P 9304 Ig-79 4 rs186512181 0.1554 None None N 0.129 0.258 None gnomAD-4.0.0 6.56418E-06 None None None None N None 0 0 None 0 1.92901E-04 None 0 0 0 0 0
D/G 9400 Ig-80 4 rs1254441947 0.619 -0.803 0.998 None 0.683 0.452 0.254761474806 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
D/G 9400 Ig-80 4 rs1254441947 0.619 -0.803 0.998 None 0.683 0.452 0.254761474806 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/G 9400 Ig-80 4 rs1254441947 0.619 -0.803 0.998 None 0.683 0.452 0.254761474806 gnomAD-4.0.0 1.23978E-05 None None None None I None 0 0 None 0 0 None 0 0 1.69588E-05 0 0
D/H 9400 Ig-80 4 None 0.7064 None 1.0 None 0.696 0.408 0.250579442822 gnomAD-4.0.0 6.84467E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99857E-07 0 0
T/N 9496 Ig-81 4 None 0.3218 None 0.999 None 0.624 0.284 0.366466682447 gnomAD-4.0.0 6.84967E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00103E-07 0 0
T/P 9496 Ig-81 4 rs1397154421 0.3727 -0.63 1.0 None 0.755 0.422 0.370608029945 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/P 9496 Ig-81 4 rs1397154421 0.3727 -0.63 1.0 None 0.755 0.422 0.370608029945 gnomAD-4.0.0 4.79488E-06 None None None None N None 0 0 None 0 0 None 0 0 6.30102E-06 0 0
T/S 9496 Ig-81 4 None 0.2168 None 0.996 None 0.451 0.2 0.170165803431 gnomAD-4.0.0 6.84967E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00103E-07 0 0
D/E 9593 Ig-82 4 None 0.366 None 1.0 None 0.383 0.174 0.159798565429 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 9593 Ig-82 4 None 0.1593 None 1.0 None 0.635 0.287 0.177238962908 gnomAD-4.0.0 1.38024E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8132E-06 0 0
V/M 9701 Ig-83 4 None 0.3561 None 0.901 None 0.464 0.202 0.466655310336 gnomAD-4.0.0 1.36981E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79987E-06 0 0
I/M 9903 Ig-84 4 rs1437200210 0.2424 None 0.934 None 0.439 0.152 0.424430313326 gnomAD-4.0.0 2.05823E-06 None None None None I None 6.00348E-05 2.24669E-05 None 0 0 None 0 0 0 0 0
E/D 9992 Ig-85 4 None 0.6227 None 0.046 None 0.16 0.046 0.0611884634855 gnomAD-4.0.0 3.18488E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72243E-06 0 0
E/K 9992 Ig-85 4 None 0.5549 None 0.969 None 0.429 0.277 0.19670166235 gnomAD-4.0.0 1.36908E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79978E-06 0 0
T/R 10081 Ig-86 4 rs1306890743 0.7077 None 1.0 None 0.839 0.51 0.861851441974 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/R 10081 Ig-86 4 rs1306890743 0.7077 None 1.0 None 0.839 0.51 0.861851441974 gnomAD-4.0.0 2.02986E-06 None None None None N None 1.74782E-05 0 None 0 0 None 0 0 1.20492E-06 0 0
V/A 13783 Ig-88 4 rs2060418351 0.4846 None 0.826 N 0.394 0.125 0.381409048467 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 13783 Ig-88 4 rs2060418351 0.4846 None 0.826 N 0.394 0.125 0.381409048467 gnomAD-4.0.0 6.5754E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47059E-05 0 0
V/A 13877 Ig-89 2 rs199969810 0.4064 None 0.132 D 0.252 0.185 0.354183961838 gnomAD-4.0.0 1.63166E-06 None None None None N None 0 2.40408E-05 None 0 0 None 0 0 0 0 0
V/G 13877 Ig-89 2 rs199969810 0.4413 -1.56 0.919 D 0.556 0.27 None gnomAD-4.0.0 2.87175E-04 None None None None N None 1.15141E-04 2.40419E-05 None 0 1.1318E-04 None 2.9905E-03 0 2.62548E-05 0 2.15637E-04
V/M 13877 Ig-89 2 rs1272825852 0.2934 -0.329 0.996 D 0.523 0.289 0.410603549233 gnomAD-2.1.1 4.36E-06 None None None None N None 0 0 None 0 0 None 3.58E-05 None 0 0 0
V/M 13877 Ig-89 2 rs1272825852 0.2934 -0.329 0.996 D 0.523 0.289 0.410603549233 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.079E-04 0
V/M 13877 Ig-89 2 rs1272825852 0.2934 -0.329 0.996 D 0.523 0.289 0.410603549233 gnomAD-4.0.0 3.90504E-06 None None None None N None 0 0 None 0 2.45483E-05 None 0 0 0 2.76068E-05 0
L/R 13968 Ig-90 4 rs879228460 0.454 None 1.0 N 0.798 0.384 0.590611164678 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
L/R 13968 Ig-90 4 rs879228460 0.454 None 1.0 N 0.798 0.384 0.590611164678 gnomAD-4.0.0 6.57393E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07211E-04 0
A/T 14057 Ig-91 4 rs376192503 0.1729 -0.548 0.248 N 0.243 0.21 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/T 14057 Ig-91 4 rs376192503 0.1729 -0.548 0.248 N 0.243 0.21 None gnomAD-4.0.0 8.21326E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89646E-06 0 1.65761E-05
A/V 14057 Ig-91 4 rs900184988 0.231 None 0.122 N 0.142 0.153 0.213573922156 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 14057 Ig-91 4 rs900184988 0.231 None 0.122 N 0.142 0.153 0.213573922156 gnomAD-4.0.0 5.07522E-06 None None None None N None 0 0 None 0 0 None 0 0 6.02489E-06 0 0
M/T 14145 Ig-92 4 rs794729427 0.104 0.041 0.003 N 0.168 0.196 0.594425430586 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.36E-05 0
M/T 14145 Ig-92 4 rs794729427 0.104 0.041 0.003 N 0.168 0.196 0.594425430586 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
M/T 14145 Ig-92 4 rs794729427 0.104 0.041 0.003 N 0.168 0.196 0.594425430586 gnomAD-4.0.0 1.17803E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61096E-05 0 0
M/V 14145 Ig-92 4 rs763513073 0.0578 -0.245 None N 0.081 0.13 0.204665344411 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.58E-05 0
M/V 14145 Ig-92 4 rs763513073 0.0578 -0.245 None N 0.081 0.13 0.204665344411 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 14145 Ig-92 4 rs763513073 0.0578 -0.245 None N 0.081 0.13 0.204665344411 gnomAD-4.0.0 6.82031E-06 None None None None N None 0 0 None 0 2.23554E-05 None 0 0 8.47877E-06 0 0
T/I 14234 Ig-93 4 None 0.1832 None 1.0 N 0.751 0.464 0.333906830038 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/G 14322 Ig-94 4 None 0.3719 None 0.971 N 0.539 0.22 0.235664433957 gnomAD-4.0.0 6.84563E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99729E-07 0 0
E/K 14322 Ig-94 4 rs760193032 0.2875 -0.891 0.971 N 0.434 0.294 0.187945064343 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 6.59E-05 None 0 0 0
E/K 14322 Ig-94 4 rs760193032 0.2875 -0.891 0.971 N 0.434 0.294 0.187945064343 gnomAD-4.0.0 4.10739E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.97253E-05 0
E/Q 14322 Ig-94 4 rs760193032 0.2247 None 0.991 N 0.458 0.229 0.178374595973 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 2.88184E-04 0 None 0 0 0 0 0
E/Q 14322 Ig-94 4 rs760193032 0.2247 None 0.991 N 0.458 0.229 0.178374595973 gnomAD-4.0.0 6.57652E-06 None None None None N None 0 0 None 2.88184E-04 0 None 0 0 0 0 0
I/F 14411 Ig-95 4 None 0.3071 None 0.989 D 0.473 0.486 0.750306904936 gnomAD-4.0.0 6.84539E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99661E-07 0 0
I/L 14411 Ig-95 4 rs1246262420 0.156 -0.31 0.031 N 0.136 0.286 0.555712064712 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
I/V 14411 Ig-95 4 None 0.1275 None 0.248 N 0.142 0.274 0.648041160416 gnomAD-4.0.0 5.47631E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19729E-06 0 0
L/F 14500 Ig-96 4 None 0.2046 None 0.934 D 0.33 0.465 0.670596422724 gnomAD-4.0.0 1.64681E-06 None None None None N None 0 0 None 0 0 None 0 0 2.93415E-06 0 0
T/I 14589 Ig-97 4 rs1171658402 0.182 -0.155 0.999 N 0.726 0.439 0.270889551736 gnomAD-2.1.1 8.28E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.84E-05 0
T/I 14589 Ig-97 4 rs1171658402 0.182 -0.155 0.999 N 0.726 0.439 0.270889551736 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/I 14589 Ig-97 4 rs1171658402 0.182 -0.155 0.999 N 0.726 0.439 0.270889551736 gnomAD-4.0.0 6.21555E-06 None None None None N None 0 0 None 0 0 None 0 0 8.48637E-06 0 0
V/E 14678 Ig-98 4 None 0.3113 None 0.966 N 0.695 0.315 0.535537035517 gnomAD-4.0.0 1.59644E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86316E-06 0 0
V/L 14678 Ig-98 4 None 0.1222 None 0.012 N 0.32 0.064 0.263612267334 gnomAD-4.0.0 6.85168E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99978E-07 0 0
V/M 14678 Ig-98 4 rs761738561 0.1596 -0.402 0.933 D 0.564 0.215 0.359557344763 gnomAD-2.1.1 8.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
V/M 14678 Ig-98 4 rs761738561 0.1596 -0.402 0.933 D 0.564 0.215 0.359557344763 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/M 14678 Ig-98 4 rs761738561 0.1596 -0.402 0.933 D 0.564 0.215 0.359557344763 gnomAD-4.0.0 2.48222E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39237E-06 0 0
L/V 14767 Ig-99 3 None 0.1153 None 0.4 N 0.408 0.057 0.253205268125 gnomAD-4.0.0 1.59332E-06 None None None None N None 5.67472E-05 0 None 0 0 None 0 0 0 0 0
T/S 14856 Ig-100 4 None 0.1612 None 0.905 N 0.294 0.185 0.345859378078 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 15034 Ig-102 4 None 0.1314 None 0.981 D 0.464 0.579 0.635921679534 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/M 15123 Ig-103 4 rs1160173197 0.2006 -0.221 0.782 N 0.521 0.109 0.53819168318 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
I/M 15123 Ig-103 4 rs1160173197 0.2006 -0.221 0.782 N 0.521 0.109 0.53819168318 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.95E-05 0 0
I/M 15123 Ig-103 4 rs1160173197 0.2006 -0.221 0.782 N 0.521 0.109 0.53819168318 gnomAD-4.0.0 1.05512E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44206E-05 0 0
I/S 15123 Ig-103 4 None 0.5636 None 0.879 N 0.519 0.341 0.748536116192 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/I 15211 Ig-104 4 rs1387120198 0.0577 -0.237 None N 0.135 0.144 0.1749357433 gnomAD-2.1.1 7.21E-06 None None None None N None 4.15E-05 0 None 0 0 None 0 None 0 0 1.42045E-04
V/I 15211 Ig-104 4 rs1387120198 0.0577 -0.237 None N 0.135 0.144 0.1749357433 gnomAD-3.1.2 2.64E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 4.42E-05 0 0
V/I 15211 Ig-104 4 rs1387120198 0.0577 -0.237 None N 0.135 0.144 0.1749357433 gnomAD-4.0.0 1.17969E-05 None None None None N None 1.34088E-05 0 None 0 0 None 0 1.65071E-04 1.01802E-05 2.20902E-05 4.81665E-05
V/A 15305 Ig-105 4 rs1281172313 0.281 -1.308 0.027 N 0.289 0.175 0.435371449458 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 5.69E-05 None 0 None 0 0 0
V/A 15305 Ig-105 4 rs1281172313 0.281 -1.308 0.027 N 0.289 0.175 0.435371449458 gnomAD-4.0.0 3.20302E-06 None None None None N None 0 0 None 0 2.79236E-05 None 0 0 0 1.44818E-05 0
V/F 15305 Ig-105 4 None 0.3122 None 0.317 N 0.42 0.128 0.231873229951 gnomAD-4.0.0 1.60184E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87171E-06 0 0
I/V 15483 Ig-107 4 None 0.1104 None 0.198 N 0.202 0.256 0.634606890218 gnomAD-4.0.0 1.59994E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86775E-06 0 0
K/I 15969 Ig-109 2 rs2057450267 0.628 None 1.0 D 0.771 0.459 0.582733548269 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/I 15969 Ig-109 2 rs2057450267 0.628 None 1.0 D 0.771 0.459 0.582733548269 gnomAD-4.0.0 6.58345E-06 None None None None N None 2.41464E-05 0 None 0 0 None 0 0 0 0 0
D/E 16958 Ig-111 4 None 0.2278 None 0.004 N 0.229 0.045 0.134241683229 gnomAD-4.0.0 1.59477E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43592E-05 0
D/V 16958 Ig-111 4 None 0.2238 None 0.83 N 0.798 0.446 0.301455362545 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/K 17254 Ig-112 4 rs370986897 0.0996 None None N 0.249 0.125 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 19098 Ig-117 4 rs766691172 0.7123 -1.368 0.999 N 0.604 0.371 0.564616066205 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 19098 Ig-117 4 rs766691172 0.7123 -1.368 0.999 N 0.604 0.371 0.564616066205 gnomAD-4.0.0 3.18522E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86648E-05 0
V/I 19098 Ig-117 4 rs727503592 0.1414 -0.438 0.997 N 0.545 0.254 0.592455534737 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.30804E-04 None 0 0 0
V/I 19098 Ig-117 4 rs727503592 0.1414 -0.438 0.997 N 0.545 0.254 0.592455534737 gnomAD-4.0.0 8.89795E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29744E-06 6.95781E-05 0
A/V 19793 Ig-119 4 rs1433039414 0.2236 -0.252 0.001 N 0.419 0.175 0.278143212241 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
A/V 19793 Ig-119 4 rs1433039414 0.2236 -0.252 0.001 N 0.419 0.175 0.278143212241 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/V 19793 Ig-119 4 rs1433039414 0.2236 -0.252 0.001 N 0.419 0.175 0.278143212241 gnomAD-4.0.0 5.12832E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57827E-06 0 0
C/R 20482 Ig-121 4 None 0.946 None 1.0 N 0.844 0.509 0.73409723825 gnomAD-4.0.0 4.93422E-06 None None None None N None 0 0 None 0 0 None 0 0 6.41534E-06 0 0
C/Y 20482 Ig-121 4 rs1457364268 0.7433 -1.038 1.0 N 0.83 0.427 0.572862713182 gnomAD-2.1.1 4.71E-06 None None None None N None 0 3.34E-05 None 0 0 None 0 None 0 0 0
D/N 20772 Ig-122 4 rs878925775 0.2685 -0.149 0.946 N 0.639 0.305 None gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
D/N 20772 Ig-122 4 rs878925775 0.2685 -0.149 0.946 N 0.639 0.305 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
D/N 20772 Ig-122 4 rs878925775 0.2685 -0.149 0.946 N 0.639 0.305 None gnomAD-4.0.0 4.33889E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93399E-06 0 0
M/K 21180 Ig-123 4 rs774558749 0.8409 -0.089 0.491 D 0.388 0.35 0.640709723699 gnomAD-4.0.0 3.2228E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89764E-06 1.4529E-05 0
M/L 21180 Ig-123 4 rs2049352693 0.1118 None None N 0.153 0.184 0.401753679984 gnomAD-4.0.0 7.56728E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.28996E-04 0
M/T 21180 Ig-123 4 rs774558749 0.6923 -0.333 0.001 N 0.261 0.28 0.741590790702 gnomAD-2.1.1 4.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.1E-06 0
M/I 21472 Ig-124 4 rs2048686621 0.6023 None 0.027 N 0.458 0.184 0.368183359018 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
M/I 21472 Ig-124 4 rs2048686621 0.6023 None 0.027 N 0.458 0.184 0.368183359018 gnomAD-4.0.0 6.57903E-06 None None None None N None 0 6.55824E-05 None 0 0 None 0 0 0 0 0
M/L 21472 Ig-124 4 None 0.1316 None None N 0.214 0.132 0.253205268125 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
M/T 21472 Ig-124 4 rs372682546 0.7387 -0.898 0.117 N 0.516 0.261 None gnomAD-2.1.1 4.3E-06 None None None None N None 6.59E-05 0 None 0 0 None 0 None 0 0 0
M/T 21472 Ig-124 4 rs372682546 0.7387 -0.898 0.117 N 0.516 0.261 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
M/T 21472 Ig-124 4 rs372682546 0.7387 -0.898 0.117 N 0.516 0.261 None gnomAD-4.0.0 5.27016E-06 None None None None N None 3.46141E-05 0 None 0 0 None 0 0 4.88696E-06 0 0
M/I 21869 Ig-125 4 rs960935807 0.8352 -1.023 0.309 N 0.557 0.256 0.4897983601 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.1E-06 0
M/I 21869 Ig-125 4 rs960935807 0.8352 -1.023 0.309 N 0.557 0.256 0.4897983601 gnomAD-4.0.0 2.74647E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60827E-06 0 0
M/T 21869 Ig-125 4 None 0.6158 None 0.684 D 0.505 0.401 0.812333785961 gnomAD-4.0.0 2.05905E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70535E-06 0 0
R/G 22268 Ig-126 4 rs762044819 0.7521 -0.05 1.0 N 0.67 0.399 0.457741393631 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 3.33E-05 None 0 0 0
R/G 22268 Ig-126 4 rs762044819 0.7521 -0.05 1.0 N 0.67 0.399 0.457741393631 gnomAD-4.0.0 1.59682E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44596E-05 0
R/K 22268 Ig-126 4 None 0.2306 None 0.997 N 0.715 0.244 0.385906861911 gnomAD-4.0.0 6.85231E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16787E-05 0
R/M 22268 Ig-126 4 None 0.7165 None 1.0 N 0.762 0.42 0.421799068777 gnomAD-4.0.0 2.05569E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70024E-06 0 0
A/T 23348 Ig-129 4 rs775146212 0.1613 -0.407 0.477 N 0.553 0.189 0.26169431596 gnomAD-2.1.1 1.28616E-04 None None None None I None 0 0 None 0 1.80115E-03 None 0 None 0 0 1.40528E-04
A/T 23348 Ig-129 4 rs775146212 0.1613 -0.407 0.477 N 0.553 0.189 0.26169431596 gnomAD-3.1.2 7.89E-05 None None None None I None 0 0 0 0 1.93798E-03 None 0 0 0 2.07125E-04 4.78011E-04
A/T 23348 Ig-129 4 rs775146212 0.1613 -0.407 0.477 N 0.553 0.189 0.26169431596 gnomAD-4.0.0 3.59475E-05 None None None None I None 0 0 None 0 9.59993E-04 None 0 0 0 1.09813E-04 8.00435E-05
Q/K 23640 Ig-130 4 rs547376963 0.1928 0.04 0.904 N 0.557 0.337 0.231873229951 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
Q/K 23640 Ig-130 4 rs547376963 0.1928 0.04 0.904 N 0.557 0.337 0.231873229951 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/K 23640 Ig-130 4 rs547376963 0.1928 0.04 0.904 N 0.557 0.337 0.231873229951 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
Q/K 23640 Ig-130 4 rs547376963 0.1928 0.04 0.904 N 0.557 0.337 0.231873229951 gnomAD-4.0.0 2.56507E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79042E-06 0 0
D/G 24032 Ig-131 4 rs1559432720 0.297 None 1.0 N 0.657 0.621 0.446211707333 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/G 24032 Ig-131 4 rs1559432720 0.297 None 1.0 N 0.657 0.621 0.446211707333 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85972E-06 0 0
D/N 24032 Ig-131 4 None 0.165 None 1.0 N 0.645 0.486 0.481099667738 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85972E-06 0 0
L/P 24434 Ig-132 4 rs778199323 0.9949 -0.287 0.998 D 0.739 0.57 0.880231576817 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
L/P 24434 Ig-132 4 rs778199323 0.9949 -0.287 0.998 D 0.739 0.57 0.880231576817 gnomAD-4.0.0 1.59207E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85964E-06 0 0
K/N 24719 Ig-133 4 rs1708348947 0.5356 None 0.935 N 0.667 0.163 0.141422826196 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
K/N 24719 Ig-133 4 rs1708348947 0.5356 None 0.935 N 0.667 0.163 0.141422826196 gnomAD-4.0.0 6.57981E-06 None None None None N None 2.41604E-05 0 None 0 0 None 0 0 0 0 0
D/H 25114 Ig-134 4 rs373701934 0.5047 -0.703 1.0 D 0.721 0.41 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 25114 Ig-134 4 rs373701934 0.5047 -0.703 1.0 D 0.721 0.41 None gnomAD-4.0.0 2.03007E-06 None None None None I None 0 0 None 0 0 None 0 0 2.40996E-06 0 0
K/T 25801 Ig-136 4 None 0.1747 None 0.117 N 0.339 0.063 0.235038932564 gnomAD-4.0.0 1.5926E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43373E-05 0
D/E 26196 Ig-137 4 None 0.6074 None 0.9 N 0.428 0.155 0.215109475489 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 26196 Ig-137 4 None 0.7654 None 0.956 N 0.465 0.41 0.327419511103 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 26196 Ig-137 4 rs777065318 0.7446 None 0.999 D 0.537 0.441 None gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 26196 Ig-137 4 rs777065318 0.7446 None 0.999 D 0.537 0.441 None gnomAD-4.0.0 1.49085E-05 None None None None I None 1.33733E-05 0 None 0 0 None 0 0 1.95251E-05 0 0
D/N 26196 Ig-137 4 rs777065318 0.3998 0.065 0.997 N 0.491 0.354 0.335414705075 gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 3.38E-05 None 0 0 0
D/N 26196 Ig-137 4 rs777065318 0.3998 0.065 0.997 N 0.491 0.354 0.335414705075 gnomAD-4.0.0 6.85989E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.17028E-05 0
E/K 26597 Ig-138 4 rs763312873 0.5792 0.513 1.0 N 0.656 0.356 0.358948522604 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 5.57E-05 None 3.27E-05 None 0 0 0
E/K 26597 Ig-138 4 rs763312873 0.5792 0.513 1.0 N 0.656 0.356 0.358948522604 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 26597 Ig-138 4 rs763312873 0.5792 0.513 1.0 N 0.656 0.356 0.358948522604 gnomAD-4.0.0 9.29733E-06 None None None None N None 0 5.004E-05 None 0 2.22965E-05 None 0 0 8.47692E-06 1.09789E-05 0
K/N 26883 Ig-139 4 None 0.4398 None 0.901 N 0.486 0.145 0.12205267543 gnomAD-4.0.0 1.59254E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8604E-06 0 0
A/T 27679 Ig-141 4 rs1704286522 0.2126 None 0.999 N 0.707 0.278 0.308278614506 gnomAD-4.0.0 1.59137E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85873E-06 0 0
V/A 28361 Ig-143 4 rs1428136058 0.2389 -1.531 0.005 N 0.187 0.104 0.442466506703 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65673E-04
V/A 28361 Ig-143 4 rs1428136058 0.2389 -1.531 0.005 N 0.187 0.104 0.442466506703 gnomAD-4.0.0 4.77321E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85798E-06 0 6.04741E-05
S/G 28758 Ig-144 4 None 0.0679 None 0.027 N 0.342 0.194 0.173771789658 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 29447 Ig-146 4 rs140201636 0.2176 0.117 None N 0.247 0.105 0.232513804876 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
T/I 29447 Ig-146 4 rs140201636 0.2176 0.117 None N 0.247 0.105 0.232513804876 gnomAD-4.0.0 6.84447E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16236E-05 0
T/K 29447 Ig-146 4 None 0.1207 None 0.211 N 0.392 0.216 0.244539031024 gnomAD-4.0.0 6.84447E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65678E-05
T/R 29447 Ig-146 4 rs140201636 0.102 -0.119 0.484 N 0.4 0.273 None gnomAD-2.1.1 2.29865E-04 None None None None N None 2.56899E-03 0 None 0 5.14E-05 None 0 None 0 0 1.40924E-04
T/R 29447 Ig-146 4 rs140201636 0.102 -0.119 0.484 N 0.4 0.273 None gnomAD-3.1.2 7.82709E-04 None None None None N None 2.70571E-03 4.58535E-04 0 0 0 None 0 0 0 0 0
T/R 29447 Ig-146 4 rs140201636 0.102 -0.119 0.484 N 0.4 0.273 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
T/R 29447 Ig-146 4 rs140201636 0.102 -0.119 0.484 N 0.4 0.273 None gnomAD-4.0.0 1.37616E-04 None None None None N None 2.74762E-03 1.5018E-04 None 0 2.23025E-05 None 0 0 1.69539E-06 0 6.40369E-05
L/V 29845 Ig-147 4 None 0.2441 None 0.055 N 0.589 0.192 0.275641507738 gnomAD-4.0.0 1.63021E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4453E-05 0
D/A 30135 Ig-148 4 None 0.1147 None 0.124 N 0.516 0.157 0.329282125956 gnomAD-4.0.0 1.36906E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79979E-06 0 0
D/Y 30135 Ig-148 4 rs1345842095 0.2175 None 0.859 N 0.615 0.286 0.626665467207 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 30135 Ig-148 4 rs1345842095 0.2175 None 0.859 N 0.615 0.286 0.626665467207 gnomAD-4.0.0 2.47984E-06 None None None None N None 1.33486E-05 0 None 0 0 None 0 0 2.54395E-06 0 0
T/N 31221 Ig-151 4 None 0.1382 None 0.939 N 0.579 0.208 0.434716162284 gnomAD-4.0.0 2.05282E-06 None None None None N None 0 2.23754E-05 None 0 0 None 0 0 1.79903E-06 0 0
T/A 32310 Ig-154 4 rs542208825 0.0589 -0.233 0.003 N 0.128 0.116 0.101711395817 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
T/A 32310 Ig-154 4 rs542208825 0.0589 -0.233 0.003 N 0.128 0.116 0.101711395817 gnomAD-4.0.0 6.88136E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04336E-07 0 0
T/P 32310 Ig-154 4 rs542208825 0.0875 -0.243 0.523 N 0.384 0.188 0.265010934533 gnomAD-2.1.1 2.89E-05 None None None None N None 0 8.62E-05 None 0 0 None 0 None 0 3.96E-05 0
T/P 32310 Ig-154 4 rs542208825 0.0875 -0.243 0.523 N 0.384 0.188 0.265010934533 gnomAD-3.1.2 1.64292E-04 None None None None N None 0 1.57191E-03 0 0 0 None 0 0 0 0 4.78469E-04
T/P 32310 Ig-154 4 rs542208825 0.0875 -0.243 0.523 N 0.384 0.188 0.265010934533 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
T/P 32310 Ig-154 4 rs542208825 0.0875 -0.243 0.523 N 0.384 0.188 0.265010934533 gnomAD-4.0.0 4.5469E-05 None None None None N None 0 5.71371E-04 None 0 0 None 0 0 2.55581E-05 0 1.44848E-04
R/C 33104 Ig-156 4 rs766169253 0.4832 -0.398 1.0 N 0.701 0.371 None gnomAD-2.1.1 2.86E-05 None None None None N None 6.54E-05 0 None 0 1.69396E-04 None 0 None 0 2.72E-05 0
R/C 33104 Ig-156 4 rs766169253 0.4832 -0.398 1.0 N 0.701 0.371 None gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 4.79846E-04
R/C 33104 Ig-156 4 rs766169253 0.4832 -0.398 1.0 N 0.701 0.371 None gnomAD-4.0.0 4.40852E-05 None None None None N None 5.34817E-05 0 None 0 4.46369E-05 None 1.57129E-05 0 5.00874E-05 0 8.01899E-05
R/H 33104 Ig-156 4 rs758617553 0.2938 -0.918 0.995 N 0.533 0.248 0.15556083564 gnomAD-2.1.1 1.09E-05 None None None None N None 4.16E-05 0 None 0 0 None 3.31E-05 None 0 7.95E-06 0
R/H 33104 Ig-156 4 rs758617553 0.2938 -0.918 0.995 N 0.533 0.248 0.15556083564 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/H 33104 Ig-156 4 rs758617553 0.2938 -0.918 0.995 N 0.533 0.248 0.15556083564 gnomAD-4.0.0 6.82943E-06 None None None None N None 1.33711E-05 0 None 0 0 None 0 0 5.94218E-06 2.20347E-05 1.60375E-05
R/L 33104 Ig-156 4 rs758617553 0.4611 None 0.821 N 0.5 0.181 0.338592109245 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/L 33104 Ig-156 4 rs758617553 0.4611 None 0.821 N 0.5 0.181 0.338592109245 gnomAD-4.0.0 6.57471E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
K/N 33499 Ig-158 4 rs1242533868 0.8114 0.323 0.998 N 0.689 0.319 0.362361684037 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.67654E-04 None 0 None 0 0 0
K/N 33499 Ig-158 4 rs1242533868 0.8114 0.323 0.998 N 0.689 0.319 0.362361684037 gnomAD-4.0.0 3.18389E-06 None None None None I None 0 0 None 0 5.5497E-05 None 0 0 0 0 0
L/F 33599 Ig-159 4 None 0.4535 None 0.996 N 0.74 0.228 0.332386209738 gnomAD-4.0.0 1.6474E-06 None None None None I None 0 0 None 0 0 None 0 0 2.96296E-06 0 0
L/I 33599 Ig-159 4 None 0.2143 None 0.722 N 0.533 0.17 0.209622950755 gnomAD-4.0.0 1.64738E-06 None None None None I None 0 0 None 0 0 None 0 0 2.96295E-06 0 0
L/P 33599 Ig-159 4 rs775361062 0.9 -0.116 1.0 N 0.76 0.457 0.721476075706 gnomAD-2.1.1 4.16E-06 None None None None I None 6.51E-05 0 None 0 0 None 0 None 0 0 0
G/A 34140 Ig-160 4 None 0.3199 None 1.0 N 0.643 0.378 0.294206760003 gnomAD-4.0.0 1.59095E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85765E-06 0 0
G/E 34140 Ig-160 4 None 0.8332 None 1.0 N 0.687 0.502 0.58541340546 gnomAD-4.0.0 1.59095E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
G/R 34140 Ig-160 4 rs1294610003 0.8179 None 1.0 N 0.661 0.483 0.685676517872 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/R 34140 Ig-160 4 rs1294610003 0.8179 None 1.0 N 0.661 0.483 0.685676517872 gnomAD-4.0.0 5.57695E-06 None None None None N None 0 0 None 0 0 None 0 0 7.62805E-06 0 0
T/I 34261 Ig-161 4 None 0.6072 None 1.0 N 0.635 0.445 0.256283259241 gnomAD-4.0.0 6.84159E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99408E-07 0 0
T/N 34261 Ig-161 4 rs985229219 0.5763 -0.146 1.0 N 0.675 0.41 0.262662153117 gnomAD-2.1.1 8.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.86E-06 0
T/N 34261 Ig-161 4 rs985229219 0.5763 -0.146 1.0 N 0.675 0.41 0.262662153117 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 34261 Ig-161 4 rs985229219 0.5763 -0.146 1.0 N 0.675 0.41 0.262662153117 gnomAD-4.0.0 1.3632E-05 None None None None N None 0 1.66694E-05 None 0 0 None 0 0 1.77984E-05 0 0
T/P 34261 Ig-161 4 rs759169479 0.6433 -0.012 1.0 N 0.623 0.511 None gnomAD-4.0.0 1.09923E-04 None None None None N None 0 6.87916E-05 None 0 5.55216E-05 None 1.00695E-03 2.4108E-04 2.00101E-05 0 9.08871E-05
T/S 34261 Ig-161 4 None 0.3888 None 0.999 N 0.511 0.351 0.197625483188 gnomAD-4.0.0 6.84159E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99408E-07 0 0
K/E 34366 Ig-162 4 None 0.9699 None 0.999 N 0.585 0.525 0.421550847248 gnomAD-4.0.0 1.59167E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
L/V 35132 Ig-164 4 None 0.2495 None 0.996 N 0.441 0.105 0.422404719673 gnomAD-4.0.0 6.8414E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99399E-07 0 0
T/A 35289 Ig-165 4 rs1381430946 0.0886 -0.78 None N 0.108 0.048 0.0666544352282 gnomAD-2.1.1 8.04E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
T/A 35289 Ig-165 4 rs1381430946 0.0886 -0.78 None N 0.108 0.048 0.0666544352282 gnomAD-4.0.0 3.18195E-06 None None None None N None 0 4.57331E-05 None 0 0 None 0 0 0 0 0
V/F 35423 Ig-166 4 rs763752622 0.1717 -0.712 0.624 N 0.406 0.128 0.504968073517 gnomAD-2.1.1 8.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 8.86E-06 0
V/F 35423 Ig-166 4 rs763752622 0.1717 -0.712 0.624 N 0.406 0.128 0.504968073517 gnomAD-3.1.2 5.26E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 8.82E-05 0 0
V/F 35423 Ig-166 4 rs763752622 0.1717 -0.712 0.624 N 0.406 0.128 0.504968073517 gnomAD-4.0.0 1.92127E-05 None None None None I None 5.07219E-05 0 None 0 0 None 0 0 2.87096E-05 0 0
K/E 35610 Ig-167 4 rs753984036 0.2464 -0.123 0.684 N 0.392 0.312 0.273503213844 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 1.65399E-04
K/E 35610 Ig-167 4 rs753984036 0.2464 -0.123 0.684 N 0.392 0.312 0.273503213844 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
K/E 35610 Ig-167 4 rs753984036 0.2464 -0.123 0.684 N 0.392 0.312 0.273503213844 gnomAD-4.0.0 3.53176E-05 None None None None N None 0 0 None 0 0 None 0 0 4.66144E-05 0 3.20184E-05
I/N 35705 Ig-168 4 None 0.4531 None 0.963 N 0.383 0.399 0.757895655473 gnomAD-4.0.0 1.59346E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02663E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.