Structural position:

  • Domain Type: Ig
  • Aligned Position: 41
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
I/V 130 Ig-2 27 rs926251115 0.2833 None 0.893 N 0.35 0.276 0.637849144695 gnomAD-3.1.2 6.57E-06 None None None -0.697(TCAP) N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 130 Ig-2 27 rs926251115 0.2833 None 0.893 N 0.35 0.276 0.637849144695 gnomAD-4.0.0 6.57142E-06 None None None -0.697(TCAP) N None 0 0 None 0 0 None 0 0 1.47011E-05 0 0
Y/C 969 Ig-3 27 rs779994150 0.3912 0.174 0.946 N 0.481 0.353 0.696690091256 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.83E-06 0
Y/H 969 Ig-3 27 rs746986462 0.2213 0.553 None N 0.245 0.095 0.296329037015 gnomAD-2.1.1 7.98E-06 None None None None I None 0 2.89E-05 None 0 0 None 0 None 0 8.83E-06 0
Y/H 969 Ig-3 27 rs746986462 0.2213 0.553 None N 0.245 0.095 0.296329037015 gnomAD-4.0.0 3.18112E-06 None None None None I None 0 2.28624E-05 None 0 0 None 0 0 2.8566E-06 0 0
Y/C 1317 Ig-5 27 rs775768014 0.3838 None 0.998 N 0.469 0.434 0.676397002788 gnomAD-4.0.0 1.36852E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.319E-05 0
R/S 1483 Ig-6 27 rs546160098 0.9477 0.012 0.942 N 0.591 0.425 0.475112344478 gnomAD-2.1.1 2.13E-05 None None None None I None 0 0 None 0 0 None 0 None 1.99124E-04 7.77E-06 0
R/S 1483 Ig-6 27 rs546160098 0.9477 0.012 0.942 N 0.591 0.425 0.475112344478 gnomAD-3.1.2 3.28E-05 None None None None I None 0 0 0 0 0 None 3.76648E-04 0 1.47E-05 0 0
R/S 1483 Ig-6 27 rs546160098 0.9477 0.012 0.942 N 0.591 0.425 0.475112344478 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/S 1483 Ig-6 27 rs546160098 0.9477 0.012 0.942 N 0.591 0.425 0.475112344478 gnomAD-4.0.0 1.92068E-05 None None None None I None 0 0 None 0 0 None 2.03909E-04 0 4.78391E-06 0 0
N/D 1582 Ig-7 27 None 0.2543 None 0.999 N 0.687 0.483 0.349647731962 gnomAD-4.0.0 1.36819E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79864E-06 0 0
N/K 1582 Ig-7 27 rs1183874678 0.4284 0.461 1.0 N 0.747 0.356 0.292062946507 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/K 1582 Ig-7 27 rs1183874678 0.4284 0.461 1.0 N 0.747 0.356 0.292062946507 gnomAD-4.0.0 3.42047E-06 None None None None I None 0 0 None 0 0 None 0 1.7337E-04 2.69796E-06 1.15931E-05 0
D/G 1731 Ig-8 29 rs876658072 0.9956 -0.344 1.0 D 0.695 0.746 0.458917189328 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/G 1731 Ig-8 29 rs876658072 0.9956 -0.344 1.0 D 0.695 0.746 0.458917189328 gnomAD-4.0.0 4.7719E-06 None None None None I None 0 0 None 0 0 None 0 0 8.56942E-06 0 0
K/E 2104 Ig-10 27 None 0.6277 None 0.477 N 0.593 0.216 0.241078983079 gnomAD-4.0.0 1.36822E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79862E-06 0 0
K/R 2104 Ig-10 27 None 0.1159 None 0.006 N 0.373 0.072 0.206339911435 gnomAD-4.0.0 1.36822E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79862E-06 0 0
E/K 2200 Ig-11 27 rs1378587847 0.3649 0.036 0.999 N 0.73 0.362 0.212008924253 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.63399E-04
E/K 2200 Ig-11 27 rs1378587847 0.3649 0.036 0.999 N 0.73 0.362 0.212008924253 gnomAD-4.0.0 6.84119E-06 None None None None N None 0 0 None 0 0 None 0 6.93481E-04 3.59731E-06 0 3.3117E-05
P/L 2292 Ig-12 26 rs1281132116 0.2203 -0.172 0.012 N 0.315 0.301 0.548571244948 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
P/L 2292 Ig-12 26 rs1281132116 0.2203 -0.172 0.012 N 0.315 0.301 0.548571244948 gnomAD-4.0.0 6.84136E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6559E-05
P/Q 2292 Ig-12 26 None 0.2922 None 0.934 N 0.46 0.284 0.462022758384 gnomAD-4.0.0 6.84136E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6559E-05
E/G 2382 Ig-13 27 rs773495315 0.3034 -0.523 0.999 D 0.625 0.715 None gnomAD-2.1.1 8.15E-05 None None None None N None 0 0 None 0 0 None 0 None 7.96E-05 1.47506E-04 2.77469E-04
E/G 2382 Ig-13 27 rs773495315 0.3034 -0.523 0.999 D 0.625 0.715 None gnomAD-3.1.2 8.54E-05 None None None None N None 0 0 0 0 0 None 0 0 1.76419E-04 0 4.78011E-04
E/G 2382 Ig-13 27 rs773495315 0.3034 -0.523 0.999 D 0.625 0.715 None gnomAD-4.0.0 2.47837E-05 None None None None N None 0 0 None 0 0 None 1.56157E-05 0 3.13563E-05 0 3.20072E-05
P/S 2471 Ig-14 27 rs1208886109 0.1465 -0.442 0.31 N 0.267 0.188 0.241664281697 gnomAD-4.0.0 1.59073E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
P/L 2646 Ig-16 26 rs1303067253 0.1631 -0.193 0.999 N 0.676 0.459 0.302459207581 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
P/L 2646 Ig-16 26 rs1303067253 0.1631 -0.193 0.999 N 0.676 0.459 0.302459207581 gnomAD-4.0.0 1.59081E-06 None None None None N None 0 0 None 0 2.77454E-05 None 0 0 0 0 0
P/S 2733 Ig-17 27 rs1407570813 0.1452 -0.21 0.669 N 0.43 0.207 0.263612267334 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
P/S 2733 Ig-17 27 rs1407570813 0.1452 -0.21 0.669 N 0.43 0.207 0.263612267334 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
P/S 2733 Ig-17 27 rs1407570813 0.1452 -0.21 0.669 N 0.43 0.207 0.263612267334 gnomAD-4.0.0 6.57713E-06 None None None None N None 2.41593E-05 0 None 0 0 None 0 0 0 0 0
H/R 2820 Ig-18 26 rs794729581 0.4393 -0.782 1.0 N 0.663 0.655 0.329282125956 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
H/R 2820 Ig-18 26 rs794729581 0.4393 -0.782 1.0 N 0.663 0.655 0.329282125956 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
H/R 2820 Ig-18 26 rs794729581 0.4393 -0.782 1.0 N 0.663 0.655 0.329282125956 gnomAD-4.0.0 6.81517E-06 None None None None N None 1.33451E-05 0 None 0 0 None 3.12324E-05 0 5.93213E-06 0 1.60026E-05
F/L 2908 Ig-19 27 None 0.9759 None 0.948 N 0.597 0.416 0.40017627803 gnomAD-4.0.0 1.59049E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
Y/C 2994 Ig-20 26 None 0.1522 None 0.993 N 0.562 0.529 0.642606198802 gnomAD-4.0.0 6.84093E-07 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 0 0 0
Y/H 2994 Ig-20 26 rs1288991244 0.0909 -0.978 0.006 N 0.236 0.153 0.236278675362 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Y/H 2994 Ig-20 26 rs1288991244 0.0909 -0.978 0.006 N 0.236 0.153 0.236278675362 gnomAD-4.0.0 4.77193E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 2.86549E-05 0
Y/N 2994 Ig-20 26 None 0.2495 None 0.761 N 0.518 0.333 0.629698297941 gnomAD-4.0.0 3.18129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71305E-06 0 0
Y/S 2994 Ig-20 26 rs745929875 0.304 -2.292 0.864 N 0.477 0.353 0.662957795054 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
Y/S 2994 Ig-20 26 rs745929875 0.304 -2.292 0.864 N 0.477 0.353 0.662957795054 gnomAD-4.0.0 2.05228E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69789E-06 0 0
P/L 3084 Ig-21 27 rs1033996370 0.7365 None 1.0 N 0.689 0.559 0.389283895039 gnomAD-4.0.0 6.84079E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99294E-07 0 0
P/R 3084 Ig-21 27 rs1033996370 0.8364 -0.216 1.0 N 0.723 0.599 0.259272394797 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/R 3084 Ig-21 27 rs1033996370 0.8364 -0.216 1.0 N 0.723 0.599 0.259272394797 gnomAD-4.0.0 2.47832E-06 None None None None N None 0 0 None 0 0 None 0 0 3.38977E-06 0 0
P/S 3084 Ig-21 27 None 0.7168 None 1.0 N 0.732 0.517 0.12205267543 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79858E-06 0 0
E/K 3172 Ig-22 26 rs754529831 0.8916 0.395 0.999 D 0.679 0.529 0.632750256606 gnomAD-2.1.1 7.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
E/K 3172 Ig-22 26 rs754529831 0.8916 0.395 0.999 D 0.679 0.529 0.632750256606 gnomAD-4.0.0 4.78877E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29518E-06 0 0
R/K 3265 Ig-23 27 None 0.1327 None None N 0.221 0.276 0.234412748748 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/S 3265 Ig-23 27 rs141708467 0.6648 -0.076 0.116 N 0.473 0.295 0.255270683199 gnomAD-2.1.1 2.48E-05 None None None None I None 2.40385E-04 2.82E-05 None 0 0 None 0 None 0 0 0
R/S 3265 Ig-23 27 rs141708467 0.6648 -0.076 0.116 N 0.473 0.295 0.255270683199 gnomAD-3.1.2 1.24888E-04 None None None None I None 4.10331E-04 6.55E-05 0 0 0 None 0 0 0 0 4.78469E-04
R/S 3265 Ig-23 27 rs141708467 0.6648 -0.076 0.116 N 0.473 0.295 0.255270683199 gnomAD-4.0.0 2.54036E-05 None None None None I None 4.6724E-04 3.334E-05 None 0 0 None 0 0 0 0 6.40184E-05
T/I 3371 Ig-24 27 rs1060500429 0.3519 None 0.966 N 0.495 0.436 0.486135451721 gnomAD-4.0.0 1.36818E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79867E-06 0 0
T/R 3371 Ig-24 27 rs1060500429 0.207 0.305 0.934 N 0.481 0.442 0.617803836188 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 3371 Ig-24 27 rs1060500429 0.207 0.305 0.934 N 0.481 0.442 0.617803836188 gnomAD-4.0.0 6.57255E-06 None None None None I None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
T/S 3371 Ig-24 27 rs770930936 0.1423 0.149 0.051 N 0.225 0.208 0.143124449307 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.8E-06 0
I/V 3491 Ig-25 27 None 0.1143 None None None None 0.101 None gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
D/Y 3686 Ig-26 27 rs548665458 0.1651 0.137 None None None 0.085 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/Y 3686 Ig-26 27 rs548665458 0.1651 0.137 None None None 0.085 None gnomAD-4.0.0 1.59131E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
E/D 3964 Ig-28 27 rs1410220479 0.1559 -0.021 None N 0.175 0.084 None gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/D 3964 Ig-28 27 rs1410220479 0.1559 -0.021 None N 0.175 0.084 None gnomAD-4.0.0 2.73669E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59775E-06 0 0
E/Q 3964 Ig-28 27 None 0.141 None 0.175 N 0.438 0.1 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/V 3964 Ig-28 27 rs756497264 0.2011 0.431 0.001 N 0.402 0.178 None gnomAD-4.0.0 1.59106E-06 None None None None I None 0 0 None 0 2.773E-05 None 0 0 0 0 0
A/V 4726 Ig-30 27 rs1241571397 0.1335 0.084 0.031 N 0.278 0.188 0.541602255418 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/V 4726 Ig-30 27 rs1241571397 0.1335 0.084 0.031 N 0.278 0.188 0.541602255418 gnomAD-4.0.0 1.59192E-06 None None None None I None 0 2.28718E-05 None 0 0 None 0 0 0 0 0
T/I 4821 Ig-31 27 rs1358712791 0.2527 None 0.994 N 0.486 0.478 0.723311353475 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 4821 Ig-31 27 rs1358712791 0.2527 None 0.994 N 0.486 0.478 0.723311353475 gnomAD-4.0.0 6.57013E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46959E-05 0 0
S/L 5008 Ig-33 28 None 0.1934 None 1.0 N 0.695 0.425 0.813890695137 gnomAD-4.0.0 2.40064E-06 None None None None I None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
T/M 5287 Ig-36 27 rs148551876 0.1453 0.138 1.0 D 0.53 0.414 None gnomAD-2.1.1 3.14355E-04 None None None None N None 3.05911E-03 0 None 0 0 None 2.28788E-04 None 0 4.69E-05 1.4041E-04
T/M 5287 Ig-36 27 rs148551876 0.1453 0.138 1.0 D 0.53 0.414 None gnomAD-3.1.2 7.10069E-04 None None None None N None 2.53525E-03 0 0 0 0 None 0 0 2.94E-05 2.07383E-04 0
T/M 5287 Ig-36 27 rs148551876 0.1453 0.138 1.0 D 0.53 0.414 None 1000 genomes 9.98403E-04 None None None None N None 3.8E-03 0 None None 0 0 None None None 0 None
T/M 5287 Ig-36 27 rs148551876 0.1453 0.138 1.0 D 0.53 0.414 None gnomAD-4.0.0 1.62353E-04 None None None None N None 2.62632E-03 3.33289E-05 None 0 0 None 0 0 2.62762E-05 2.41562E-04 1.60046E-04
S/A 5383 Ig-37 27 rs758960111 0.3267 0.016 0.973 N 0.479 0.332 0.372087925617 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
S/A 5383 Ig-37 27 rs758960111 0.3267 0.016 0.973 N 0.479 0.332 0.372087925617 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/A 5383 Ig-37 27 rs758960111 0.3267 0.016 0.973 N 0.479 0.332 0.372087925617 gnomAD-4.0.0 6.57488E-06 None None None None I None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
S/F 5383 Ig-37 27 rs774061411 0.832 -0.75 0.999 N 0.71 0.43 0.691664804554 gnomAD-2.1.1 8.06E-06 None None None None I None 0 2.91E-05 None 0 0 None 3.27E-05 None 0 0 0
S/F 5383 Ig-37 27 rs774061411 0.832 -0.75 0.999 N 0.71 0.43 0.691664804554 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07125E-04 0
S/F 5383 Ig-37 27 rs774061411 0.832 -0.75 0.999 N 0.71 0.43 0.691664804554 gnomAD-4.0.0 4.33884E-06 None None None None I None 0 1.66845E-05 None 0 0 None 0 0 1.69536E-06 4.39338E-05 0
S/T 5383 Ig-37 27 rs758960111 0.2528 0.045 0.543 N 0.336 0.278 0.302793454619 gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
S/T 5383 Ig-37 27 rs758960111 0.2528 0.045 0.543 N 0.336 0.278 0.302793454619 gnomAD-3.1.2 2.63E-05 None None None None I None 9.66E-05 0 0 0 0 None 0 0 0 0 0
S/T 5383 Ig-37 27 rs758960111 0.2528 0.045 0.543 N 0.336 0.278 0.302793454619 gnomAD-4.0.0 2.62995E-05 None None None None I None 9.65624E-05 0 None 0 0 None 0 0 0 0 0
S/T 5476 Ig-38 27 None 0.0861 None 0.003 N 0.18 0.157 0.281381271821 gnomAD-4.0.0 8.40227E-06 None None None None I None 0 0 None 0 0 None 0 0 9.18753E-06 0 0
S/Y 5476 Ig-38 27 None 0.4482 None 0.473 N 0.626 0.367 0.647671066071 gnomAD-4.0.0 1.59239E-06 None None None None I None 0 0 None 0 0 None 1.88381E-05 0 0 0 0
T/I 5570 Ig-39 28 rs535319438 0.3679 -0.04 0.984 N 0.497 0.288 0.535726849619 gnomAD-2.1.1 1.04682E-04 None None None None N None 0 0 None 0 7.79597E-04 None 3.26883E-04 None 0 0 3.32116E-04
T/I 5570 Ig-39 28 rs535319438 0.3679 -0.04 0.984 N 0.497 0.288 0.535726849619 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.77812E-04 None 0 0 0 0 0
T/I 5570 Ig-39 28 rs535319438 0.3679 -0.04 0.984 N 0.497 0.288 0.535726849619 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
T/I 5570 Ig-39 28 rs535319438 0.3679 -0.04 0.984 N 0.497 0.288 0.535726849619 gnomAD-4.0.0 3.47017E-05 None None None None N None 0 0 None 0 4.90327E-04 None 0 0 0 2.7455E-04 1.44055E-04
T/N 5570 Ig-39 28 rs535319438 0.1807 -0.416 0.896 N 0.491 0.17 0.387850303812 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/N 5570 Ig-39 28 rs535319438 0.1807 -0.416 0.896 N 0.491 0.17 0.387850303812 gnomAD-4.0.0 2.05268E-06 None None None None N None 0 4.47227E-05 None 0 0 None 0 0 8.99481E-07 0 0
T/I 5663 Ig-40 27 rs1370225459 0.5665 0.154 0.984 N 0.527 0.363 0.511275995344 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/I 5663 Ig-40 27 rs1370225459 0.5665 0.154 0.984 N 0.527 0.363 0.511275995344 gnomAD-4.0.0 6.15816E-06 None None None None I None 0 0 None 0 0 None 0 0 8.09556E-06 0 0
T/P 5663 Ig-40 27 rs1385425356 0.5518 -0.109 0.984 N 0.521 0.312 0.587058026133 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/P 5663 Ig-40 27 rs1385425356 0.5518 -0.109 0.984 N 0.521 0.312 0.587058026133 gnomAD-4.0.0 1.59144E-06 None None None None I None 0 2.28697E-05 None 0 0 None 0 0 0 0 0
T/S 5663 Ig-40 27 None 0.1309 None 0.046 N 0.217 0.115 0.159798565429 gnomAD-4.0.0 1.36848E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79901E-06 0 0
S/C 5756 Ig-41 27 rs367634185 0.2932 -0.321 1.0 N 0.617 0.492 None gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
S/C 5756 Ig-41 27 rs367634185 0.2932 -0.321 1.0 N 0.617 0.492 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/C 5756 Ig-41 27 rs367634185 0.2932 -0.321 1.0 N 0.617 0.492 None gnomAD-4.0.0 6.57263E-06 None None None None I None 2.41255E-05 0 None 0 0 None 0 0 0 0 0
S/F 5756 Ig-41 27 rs367634185 0.4174 None 0.999 D 0.686 0.462 0.727048445308 gnomAD-4.0.0 1.59185E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85887E-06 0 0
S/P 5756 Ig-41 27 rs2080496775 0.7537 None 0.999 N 0.603 0.501 0.399740851666 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/P 5756 Ig-41 27 rs2080496775 0.7537 None 0.999 N 0.603 0.501 0.399740851666 gnomAD-4.0.0 6.57333E-06 None None None None I None 0 6.54879E-05 None 0 0 None 0 0 0 0 0
T/I 5849 Ig-42 27 None 0.7975 None 1.0 N 0.761 0.427 0.648752727461 gnomAD-4.0.0 1.59141E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/A 5945 Ig-43 27 rs776790387 0.6128 0.03 0.973 N 0.485 0.358 None gnomAD-4.0.0 2.97189E-04 None None None None I None 2.98972E-05 2.24095E-05 None 0 1.54149E-03 None 6.61336E-03 0 8.99638E-06 2.31927E-05 1.65926E-04
S/P 5945 Ig-43 27 rs776790387 0.9801 0.071 0.999 N 0.631 0.517 0.524480850804 gnomAD-2.1.1 2.86E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.36E-05 0
S/P 5945 Ig-43 27 rs776790387 0.9801 0.071 0.999 N 0.631 0.517 0.524480850804 gnomAD-3.1.2 3.94E-05 None None None None I None 0 0 0 0 0 None 0 0 8.82E-05 0 0
S/P 5945 Ig-43 27 rs776790387 0.9801 0.071 0.999 N 0.631 0.517 0.524480850804 gnomAD-4.0.0 6.57329E-05 None None None None I None 0 0 None 0 0 None 0 0 8.73197E-05 0 4.8097E-05
T/A 6132 Ig-45 28 None 0.148 None 0.999 N 0.58 0.29 0.382925413656 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 6225 Ig-46 27 rs794727818 0.2609 None 0.948 D 0.528 0.224 0.32471235697 gnomAD-4.0.0 1.36859E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.31356E-05
T/K 6225 Ig-46 27 None 0.4916 None 0.997 N 0.612 0.363 0.589254406313 gnomAD-4.0.0 1.59172E-06 None None None None I None 0 0 None 0 0 None 0 2.41663E-04 0 0 0
T/S 6225 Ig-46 27 None 0.1777 None 0.775 N 0.28 0.127 0.234412748748 gnomAD-4.0.0 6.84296E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99575E-07 0 0
S/C 6318 Ig-47 27 None 0.2675 None 0.996 N 0.54 0.429 0.706475442758 gnomAD-4.0.0 3.19025E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72646E-06 0 0
T/A 6600 Ig-50 27 rs530353051 0.1644 -0.423 0.993 N 0.587 0.349 0.424194796918 gnomAD-2.1.1 2.82E-05 None None None None I None 0 1.73974E-04 None 0 0 None 0 None 0 8.89E-06 0
T/A 6600 Ig-50 27 rs530353051 0.1644 -0.423 0.993 N 0.587 0.349 0.424194796918 gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.55E-05 0 2.88018E-04 0 None 0 0 1.47E-05 0 0
T/A 6600 Ig-50 27 rs530353051 0.1644 -0.423 0.993 N 0.587 0.349 0.424194796918 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
T/A 6600 Ig-50 27 rs530353051 0.1644 -0.423 0.993 N 0.587 0.349 0.424194796918 gnomAD-4.0.0 1.6664E-05 None None None None I None 0 1.69497E-04 None 4.09433E-05 0 None 0 0 4.79058E-06 0 0
T/I 6600 Ig-50 27 rs1355564295 0.4029 0.119 1.0 N 0.765 0.42 0.528614029291 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 6600 Ig-50 27 rs1355564295 0.4029 0.119 1.0 N 0.765 0.42 0.528614029291 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 3.66327E-05
S/F 6694 Ig-51 28 rs774576049 0.2715 -0.861 0.299 N 0.46 0.324 0.579300295483 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/Y 6694 Ig-51 28 None 0.2628 None 0.99 D 0.673 0.511 0.679282971961 gnomAD-4.0.0 4.10716E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39858E-06 0 0
T/I 6787 Ig-52 27 None 0.4419 None 0.998 N 0.671 0.389 0.619501705969 gnomAD-4.0.0 1.59677E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86788E-06 0 0
T/S 6787 Ig-52 27 None 0.1844 None 0.154 N 0.288 0.079 0.149567049428 gnomAD-4.0.0 2.05521E-06 None None None None I None 8.9815E-05 0 None 0 0 None 0 0 0 0 0
A/S 6880 Ig-53 27 None 0.0651 None None N 0.151 0.12 0.101711395817 gnomAD-4.0.0 6.84628E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99836E-07 0 0
A/T 6880 Ig-53 27 rs753356990 0.0634 -0.386 0.001 N 0.164 0.089 0.149567049428 gnomAD-2.1.1 1.79E-05 None None None None I None 0 0 None 0 0 None 3.28E-05 None 4.01E-05 1.57E-05 1.41363E-04
A/T 6880 Ig-53 27 rs753356990 0.0634 -0.386 0.001 N 0.164 0.089 0.149567049428 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 9.43E-05 0 2.94E-05 0 0
A/T 6880 Ig-53 27 rs753356990 0.0634 -0.386 0.001 N 0.164 0.089 0.149567049428 gnomAD-4.0.0 1.24013E-05 None None None None I None 1.33601E-05 0 None 0 2.22975E-05 None 3.12617E-05 4.94723E-04 8.47959E-06 2.20022E-05 1.60226E-05
A/V 6880 Ig-53 27 rs763878064 0.0793 -0.127 None N 0.176 0.134 0.383256108077 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
A/V 6880 Ig-53 27 rs763878064 0.0793 -0.127 None N 0.176 0.134 0.383256108077 gnomAD-4.0.0 6.16116E-06 None None None None I None 0 0 None 0 0 None 0 0 8.09816E-06 0 0
T/P 6974 Ig-54 27 None 0.5557 None 0.999 D 0.672 0.444 0.649470034893 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/S 6974 Ig-54 27 rs774828625 0.1364 -0.038 0.905 N 0.383 0.166 0.329282125956 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
T/I 7163 Ig-56 27 rs370324138 0.3449 0.115 0.991 N 0.673 0.264 0.534620942121 gnomAD-2.1.1 1.21E-05 None None None None I None 0 8.75E-05 None 0 0 None 0 None 0 0 0
T/I 7163 Ig-56 27 rs370324138 0.3449 0.115 0.991 N 0.673 0.264 0.534620942121 gnomAD-3.1.2 2.63E-05 None None None None I None 0 2.62055E-04 0 0 0 None 0 0 0 0 0
T/I 7163 Ig-56 27 rs370324138 0.3449 0.115 0.991 N 0.673 0.264 0.534620942121 gnomAD-4.0.0 4.95995E-06 None None None None I None 0 1.00157E-04 None 0 0 None 0 0 8.47836E-07 1.0997E-05 0
T/N 7163 Ig-56 27 rs370324138 0.1566 -0.179 0.982 N 0.623 0.169 0.408172294925 gnomAD-2.1.1 8.08E-06 None None None None I None 0 0 None 0 5.6E-05 None 0 None 0 8.93E-06 0
T/N 7163 Ig-56 27 rs370324138 0.1566 -0.179 0.982 N 0.623 0.169 0.408172294925 gnomAD-4.0.0 1.23219E-05 None None None None I None 0 0 None 0 0 None 0 0 1.43952E-05 1.16128E-05 1.65793E-05
T/I 7256 Ig-57 27 None 0.3747 None 0.984 D 0.419 0.274 0.497613835824 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 7445 Ig-59 27 None 0.1537 None 0.2 N 0.276 0.175 0.186928172975 gnomAD-4.0.0 1.59199E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
A/P 7541 Ig-60 27 rs2078459574 0.2572 None 0.939 N 0.448 0.321 0.418221603839 gnomAD-4.0.0 1.30054E-05 None None None None I None 0 0 None 0 0 None 0 0 1.70948E-05 0 0
S/F 7635 Ig-61 28 rs1268436239 0.2573 -0.833 0.992 N 0.586 0.399 0.817150913411 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/F 7635 Ig-61 28 rs1268436239 0.2573 -0.833 0.992 N 0.586 0.399 0.817150913411 gnomAD-4.0.0 2.05336E-06 None None None None I None 0 0 None 0 2.51953E-05 None 0 0 1.79957E-06 0 0
T/A 7728 Ig-62 27 rs760839592 0.2762 -0.29 0.847 N 0.551 0.217 0.281381271821 gnomAD-2.1.1 8.07E-06 None None None None I None 0 5.81E-05 None 0 0 None 0 None 0 0 0
T/A 7728 Ig-62 27 rs760839592 0.2762 -0.29 0.847 N 0.551 0.217 0.281381271821 gnomAD-4.0.0 4.77692E-06 None None None None I None 0 6.86342E-05 None 0 0 None 0 0 0 0 0
F/L 7821 Ig-63 27 rs1478276063 0.6237 -0.14 0.047 N 0.249 0.288 0.368183359018 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
F/L 7821 Ig-63 27 rs1478276063 0.6237 -0.14 0.047 N 0.249 0.288 0.368183359018 gnomAD-4.0.0 8.21097E-06 None None None None I None 0 0 None 0 0 None 0 0 1.07941E-05 0 0
S/L 8011 Ig-65 27 rs771628562 0.4283 0.124 0.014 N 0.436 0.345 0.510113526977 gnomAD-4.0.0 1.59125E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85837E-06 0 0
S/P 8011 Ig-65 27 rs774921957 0.881 -0.096 0.97 N 0.475 0.392 0.426787303895 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 9.95E-05 0 None 0 None 0 0 0
S/P 8011 Ig-65 27 rs774921957 0.881 -0.096 0.97 N 0.475 0.392 0.426787303895 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 2.88351E-04 0 None 0 0 0 0 0
S/P 8011 Ig-65 27 rs774921957 0.881 -0.096 0.97 N 0.475 0.392 0.426787303895 gnomAD-4.0.0 6.8168E-06 None None None None I None 1.33515E-05 0 None 1.68919E-04 0 None 0 1.64528E-04 2.54291E-06 0 1.60102E-05
T/I 8104 Ig-66 27 None 0.3358 None 0.782 N 0.553 0.251 0.42538462244 gnomAD-4.0.0 1.59177E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
T/I 8197 Ig-67 27 rs748587371 0.3568 -0.163 0.966 N 0.446 0.295 0.498001352042 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/I 8197 Ig-67 27 rs748587371 0.3568 -0.163 0.966 N 0.446 0.295 0.498001352042 gnomAD-4.0.0 8.21081E-06 None None None None N None 0 0 None 0 2.51991E-05 None 0 0 8.99486E-06 0 1.65689E-05
T/K 8197 Ig-67 27 rs748587371 0.3793 -0.613 0.801 N 0.457 0.324 0.47558534428 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/N 8290 Ig-68 27 None 0.1662 None 0.969 N 0.464 0.274 0.521015664611 gnomAD-4.0.0 1.6026E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
S/F 8576 Ig-71 28 rs376095355 0.2105 -0.74 1.0 N 0.592 0.45 None gnomAD-2.1.1 8.2E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.09E-06 1.68577E-04
S/F 8576 Ig-71 28 rs376095355 0.2105 -0.74 1.0 N 0.592 0.45 None gnomAD-4.0.0 1.16503E-05 None None None None I None 0 0 None 0 0 None 0 0 1.1706E-05 0 6.63768E-05
S/P 8576 Ig-71 28 rs1176708240 0.8661 -0.081 0.998 D 0.431 0.492 0.52628473709 gnomAD-2.1.1 4.11E-06 None None None None I None 0 0 None 0 0 None 3.34E-05 None 0 0 0
S/P 8576 Ig-71 28 rs1176708240 0.8661 -0.081 0.998 D 0.431 0.492 0.52628473709 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07814E-04 0
S/P 8576 Ig-71 28 rs1176708240 0.8661 -0.081 0.998 D 0.431 0.492 0.52628473709 gnomAD-4.0.0 6.42695E-06 None None None None I None 0 0 None 0 0 None 0 2.24115E-04 0 5.39345E-05 0
T/I 8669 Ig-72 27 rs773386252 0.6004 0.103 0.998 N 0.667 0.403 0.579560680208 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65618E-04
T/S 8669 Ig-72 27 rs773386252 0.169 -0.288 0.157 N 0.295 0.084 0.202949470691 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/S 8669 Ig-72 27 rs773386252 0.169 -0.288 0.157 N 0.295 0.084 0.202949470691 gnomAD-4.0.0 1.59147E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85894E-06 0 0
A/T 8762 Ig-73 27 rs1336984327 0.0659 -0.468 0.001 N 0.145 0.041 0.170165803431 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
A/T 8762 Ig-73 27 rs1336984327 0.0659 -0.468 0.001 N 0.145 0.041 0.170165803431 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/T 8762 Ig-73 27 rs1336984327 0.0659 -0.468 0.001 N 0.145 0.041 0.170165803431 gnomAD-4.0.0 9.29769E-06 None None None None I None 0 0 None 6.75813E-05 0 None 0 0 1.01726E-05 0 1.60159E-05
A/V 8762 Ig-73 27 None 0.08 None 0.148 N 0.311 0.289 0.41921206133 gnomAD-4.0.0 1.59196E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
T/N 8856 Ig-74 27 rs1331657608 0.1215 None 0.982 N 0.509 0.34 0.540697301583 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 8856 Ig-74 27 rs1331657608 0.1215 None 0.982 N 0.509 0.34 0.540697301583 gnomAD-4.0.0 6.57566E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47033E-05 0 0
T/A 9045 Ig-76 27 None 0.1268 None 0.001 N 0.183 0.085 0.229924730088 gnomAD-4.0.0 1.59199E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85896E-06 0 0
T/K 9045 Ig-76 27 None 0.275 None 0.062 N 0.392 0.212 0.37568098594 gnomAD-4.0.0 6.8436E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99552E-07 0 0
T/I 9138 Ig-77 27 None 0.2094 None 0.126 N 0.389 0.214 0.346315397577 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/N 9138 Ig-77 27 None 0.1132 None 0.89 N 0.551 0.163 0.39162414616 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 9423 Ig-80 27 None 0.3361 None 0.669 None 0.443 0.355 0.508398094826 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/A 9724 Ig-83 27 None 0.439 None 0.999 None 0.642 0.478 0.538745750885 gnomAD-4.0.0 1.59494E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8675E-06 0 0
D/N 9724 Ig-83 27 rs778955269 0.1472 0.344 0.999 None 0.706 0.373 0.323342291347 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 1.31406E-04 None 0 0 0
D/N 9724 Ig-83 27 rs778955269 0.1472 0.344 0.999 None 0.706 0.373 0.323342291347 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/N 9724 Ig-83 27 rs778955269 0.1472 0.344 0.999 None 0.706 0.373 0.323342291347 gnomAD-4.0.0 6.2033E-06 None None None None I None 0 1.668E-05 None 0 0 None 0 0 0 9.90099E-05 0
V/L 10014 Ig-85 26 rs745949099 0.4646 0.002 0.76 None 0.488 0.1 0.614608367865 gnomAD-2.1.1 4.01E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/L 10014 Ig-85 26 rs745949099 0.4646 0.002 0.76 None 0.488 0.1 0.614608367865 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 10014 Ig-85 26 rs745949099 0.4646 0.002 0.76 None 0.488 0.1 0.614608367865 gnomAD-4.0.0 3.84235E-06 None None None None N None 5.07322E-05 0 None 0 0 None 0 0 0 0 0
S/C 13713 Ig-87 30 None 0.904 None 1.0 D 0.711 0.544 0.683316155328 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79922E-06 0 0
S/P 13713 Ig-87 30 None 0.765 None 1.0 N 0.715 0.547 0.394685799254 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 13991 Ig-90 27 rs1247699000 0.0892 -0.589 0.006 N 0.243 0.059 0.0716867268079 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
A/S 13991 Ig-90 27 rs1247699000 0.0892 -0.589 0.006 N 0.243 0.059 0.0716867268079 gnomAD-4.0.0 1.5923E-06 None None None None N None 0 0 None 0 0 None 1.88296E-05 0 0 0 0
E/D 14434 Ig-95 27 None 0.1972 None 0.896 N 0.389 0.332 0.355658859761 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 14434 Ig-95 27 None 0.1561 None 0.811 D 0.408 0.464 0.382592752248 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
A/E 14612 Ig-97 27 rs965521601 0.1946 -0.634 0.002 N 0.331 0.183 0.440182696023 gnomAD-2.1.1 6.38E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.29685E-04 0
A/E 14612 Ig-97 27 rs965521601 0.1946 -0.634 0.002 N 0.331 0.183 0.440182696023 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/E 14612 Ig-97 27 rs965521601 0.1946 -0.634 0.002 N 0.331 0.183 0.440182696023 gnomAD-4.0.0 1.67398E-05 None None None None N None 0 0 None 0 0 None 0 0 2.28904E-05 0 0
E/D 14700 Ig-98 26 None 0.3855 None 0.007 N 0.231 0.058 0.19670166235 gnomAD-4.0.0 1.59225E-06 None None None None N None 0 0 None 0 0 None 0 2.41779E-04 0 0 0
E/K 14790 Ig-99 26 rs762712953 0.1863 0.615 1.0 N 0.725 0.446 0.413635276047 gnomAD-2.1.1 2.5E-05 None None None None N None 0 5.67E-05 None 0 0 None 6.54E-05 None 0 2.35E-05 0
E/K 14790 Ig-99 26 rs762712953 0.1863 0.615 1.0 N 0.725 0.446 0.413635276047 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 4.79386E-04
E/K 14790 Ig-99 26 rs762712953 0.1863 0.615 1.0 N 0.725 0.446 0.413635276047 gnomAD-4.0.0 8.6807E-06 None None None None N None 1.33586E-05 3.33578E-05 None 0 0 None 0 0 6.78357E-06 2.1966E-05 1.60246E-05
E/Q 14790 Ig-99 26 rs762712953 0.1901 None 1.0 D 0.691 0.439 0.39619538035 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94326E-04 None 0 0 0 0 0
E/Q 14790 Ig-99 26 rs762712953 0.1901 None 1.0 D 0.691 0.439 0.39619538035 gnomAD-4.0.0 6.57609E-06 None None None None N None 0 0 None 0 1.94326E-04 None 0 0 0 0 0
P/S 15057 Ig-102 27 None 0.1199 None 0.987 D 0.648 0.62 0.50466331119 gnomAD-4.0.0 6.84736E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99947E-07 0 0
E/K 15234 Ig-104 27 rs1457956988 0.2445 None 0.822 N 0.623 0.353 0.396645960531 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 1.94856E-04 None 0 0 0 2.06954E-04 0
E/K 15234 Ig-104 27 rs1457956988 0.2445 None 0.822 N 0.623 0.353 0.396645960531 gnomAD-4.0.0 7.69807E-06 None None None None N None 0 0 None 0 9.74991E-05 None 0 0 0 1.34081E-05 2.849E-05
D/H 15506 Ig-107 27 rs755611206 0.7545 -0.034 0.997 D 0.715 0.653 0.509937682487 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 1.40607E-04
D/H 15506 Ig-107 27 rs755611206 0.7545 -0.034 0.997 D 0.715 0.653 0.509937682487 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.58E-05 0 0 0 None 0 0 4.42E-05 0 0
D/H 15506 Ig-107 27 rs755611206 0.7545 -0.034 0.997 D 0.715 0.653 0.509937682487 gnomAD-4.0.0 3.28747E-05 None None None None N None 0 1.67062E-05 None 0 0 None 0 0 4.24121E-05 0 3.20616E-05
D/V 15506 Ig-107 27 rs748069813 0.6638 0.237 0.978 D 0.721 0.736 0.820832588438 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/V 15506 Ig-107 27 rs748069813 0.6638 0.237 0.978 D 0.721 0.736 0.820832588438 gnomAD-4.0.0 1.59429E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43398E-05 0
D/Y 15506 Ig-107 27 rs755611206 0.6256 None 0.997 D 0.737 0.64 0.782613236998 gnomAD-4.0.0 6.84772E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65854E-05
Y/H 15594 Ig-108 27 rs727504196 0.3017 0.625 0.908 N 0.644 0.432 0.473458370588 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
Y/H 15594 Ig-108 27 rs727504196 0.3017 0.625 0.908 N 0.644 0.432 0.473458370588 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/H 15594 Ig-108 27 rs727504196 0.3017 0.625 0.908 N 0.644 0.432 0.473458370588 gnomAD-4.0.0 2.35807E-05 None None None None N None 0 0 None 0 0 None 0 0 3.22379E-05 0 0
Y/S 15989 Ig-109 22 rs2057440561 0.406 None 1.0 D 0.686 0.577 0.784478220262 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
Y/S 15989 Ig-109 22 rs2057440561 0.406 None 1.0 D 0.686 0.577 0.784478220262 gnomAD-4.0.0 2.48052E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.39252E-05 0
K/Q 16285 Ig-110 24 rs780017546 0.3401 0.183 0.946 N 0.681 0.232 0.236890367714 gnomAD-2.1.1 2.83E-05 None None None None I None 0 0 None 5.98683E-04 0 None 0 None 0 8.94E-06 0
K/Q 16285 Ig-110 24 rs780017546 0.3401 0.183 0.946 N 0.681 0.232 0.236890367714 gnomAD-3.1.2 3.29E-05 None None None None I None 0 0 0 1.15407E-03 0 None 0 0 1.47E-05 0 0
K/Q 16285 Ig-110 24 rs780017546 0.3401 0.183 0.946 N 0.681 0.232 0.236890367714 gnomAD-4.0.0 1.11643E-05 None None None None I None 0 0 None 4.73581E-04 0 None 0 0 3.39239E-06 0 0
V/A 16981 Ig-111 27 rs1323997384 0.4772 None 0.999 N 0.577 0.351 0.651059218688 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 16981 Ig-111 27 rs1323997384 0.4772 None 0.999 N 0.577 0.351 0.651059218688 gnomAD-4.0.0 6.58025E-06 None None None None I None 2.41488E-05 0 None 0 0 None 0 0 0 0 0
S/L 17274 Ig-112 24 None 0.1354 None 0.565 N 0.617 0.313 0.653797162166 gnomAD-4.0.0 1.59398E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8627E-06 0 0
S/T 17274 Ig-112 24 None 0.1287 None 0.722 D 0.473 0.21 0.329282125956 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 17699 Ig-113 23 rs760963888 0.4384 -0.043 1.0 N 0.651 0.412 0.612736520223 gnomAD-2.1.1 2.51E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 3.15E-05 1.40568E-04
R/C 17699 Ig-113 23 rs760963888 0.4384 -0.043 1.0 N 0.651 0.412 0.612736520223 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.95E-05 0 0
R/C 17699 Ig-113 23 rs760963888 0.4384 -0.043 1.0 N 0.651 0.412 0.612736520223 gnomAD-4.0.0 1.48798E-05 None None None None I None 0 6.67178E-05 None 0 0 None 0 0 1.18708E-05 6.58848E-05 0
R/H 17699 Ig-113 23 None 0.2541 -0.609 1.0 N 0.501 0.365 None gnomAD-2.1.1 1.77036E-03 None None None None I None 6.62691E-04 1.07527E-03 None 1.35633E-03 7.19868E-04 None 1.69957E-03 None 1.60013E-04 2.73852E-03 1.12423E-03
R/H 17699 Ig-113 23 None 0.2541 -0.609 1.0 N 0.501 0.365 None gnomAD-3.1.2 1.58636E-03 None None None None I None 6.76459E-04 1.37777E-03 0 1.15274E-03 5.8434E-04 None 2.82805E-04 0 2.57626E-03 1.03605E-03 9.56023E-04
R/H 17699 Ig-113 23 None 0.2541 -0.609 1.0 N 0.501 0.365 None 1000 genomes 1.19808E-03 None None None None I None 8E-04 1.4E-03 None None 0 3E-03 None None None 1E-03 None
R/H 17699 Ig-113 23 None 0.2541 -0.609 1.0 N 0.501 0.365 None gnomAD-4.0.0 2.24162E-03 None None None None I None 5.60403E-04 1.20052E-03 None 1.01372E-03 4.24202E-04 None 5.1598E-04 4.9554E-04 2.67599E-03 1.72395E-03 1.66549E-03
R/L 17699 Ig-113 23 rs72646808 0.6889 0.511 0.996 N 0.565 0.368 0.54988173901 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
R/L 17699 Ig-113 23 rs72646808 0.6889 0.511 0.996 N 0.565 0.368 0.54988173901 gnomAD-4.0.0 1.36885E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79944E-06 0 0
R/P 17699 Ig-113 23 rs72646808 0.9916 None 1.0 N 0.585 0.415 0.608695890411 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/P 17699 Ig-113 23 rs72646808 0.9916 None 1.0 N 0.585 0.415 0.608695890411 gnomAD-4.0.0 1.85989E-06 None None None None I None 4.00941E-05 0 None 0 0 None 0 0 0 0 0
R/C 18405 Ig-115 24 rs199656264 0.4282 -0.097 1.0 N 0.763 0.436 None gnomAD-2.1.1 3.58E-05 None None None None I None 8.28E-05 5.67E-05 None 0 5.16E-05 None 3.27E-05 None 0 2.35E-05 1.40647E-04
R/C 18405 Ig-115 24 rs199656264 0.4282 -0.097 1.0 N 0.763 0.436 None gnomAD-3.1.2 3.29E-05 None None None None I None 2.42E-05 0 0 0 0 None 0 0 5.89E-05 0 0
R/C 18405 Ig-115 24 rs199656264 0.4282 -0.097 1.0 N 0.763 0.436 None gnomAD-4.0.0 3.16274E-05 None None None None I None 1.33704E-05 3.33912E-05 None 0 0 None 0 0 3.81613E-05 2.19761E-05 1.60267E-05
R/H 18405 Ig-115 24 rs771921519 0.2213 -0.785 1.0 N 0.762 0.4 0.473143432122 gnomAD-2.1.1 2.82E-05 None None None None I None 0 1.74135E-04 None 0 0 None 0 None 0 8.91E-06 0
R/H 18405 Ig-115 24 rs771921519 0.2213 -0.785 1.0 N 0.762 0.4 0.473143432122 gnomAD-4.0.0 1.02688E-05 None None None None I None 0 1.34282E-04 None 0 0 None 0 0 8.09865E-06 0 0
V/G 18711 Ig-116 24 rs769265168 0.488 -0.671 0.317 D 0.537 0.365 0.798137268733 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/G 18711 Ig-116 24 rs769265168 0.488 -0.671 0.317 D 0.537 0.365 0.798137268733 gnomAD-4.0.0 3.42468E-06 None None None None I None 0 0 None 0 0 None 0 0 4.5E-06 0 0
K/M 19119 Ig-117 25 rs1576219870 0.5471 None 1.0 D 0.728 0.489 0.488548280593 gnomAD-4.0.0 1.59232E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
V/G 20105 Ig-120 26 rs727504490 0.442 -0.36 0.995 N 0.617 0.463 0.837754063024 gnomAD-2.1.1 2.16E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.94E-05 1.41844E-04
V/G 20105 Ig-120 26 rs727504490 0.442 -0.36 0.995 N 0.617 0.463 0.837754063024 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 3.16456E-03 4.41E-05 0 0
V/G 20105 Ig-120 26 rs727504490 0.442 -0.36 0.995 N 0.617 0.463 0.837754063024 gnomAD-4.0.0 2.54463E-05 None None None None I None 0 0 None 0 0 None 0 1.65673E-03 2.37567E-05 1.10385E-05 3.2079E-05
V/M 20105 Ig-120 26 rs2050166133 0.1525 None 0.968 N 0.425 0.214 0.687798333245 gnomAD-4.0.0 3.42767E-06 None None None None I None 0 0 None 0 0 None 0 0 4.50244E-06 0 0
R/L 21201 Ig-123 25 None 0.8406 None 1.0 N 0.638 0.502 0.747437394213 gnomAD-4.0.0 6.84595E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65777E-05
R/Q 21201 Ig-123 25 rs763273464 0.4215 0.018 1.0 N 0.719 0.438 0.437420747294 gnomAD-2.1.1 2.42E-05 None None None None I None 0 8.72E-05 None 0 0 None 0 None 9.31E-05 8.92E-06 0
R/Q 21201 Ig-123 25 rs763273464 0.4215 0.018 1.0 N 0.719 0.438 0.437420747294 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/Q 21201 Ig-123 25 rs763273464 0.4215 0.018 1.0 N 0.719 0.438 0.437420747294 gnomAD-4.0.0 1.17811E-05 None None None None I None 2.67173E-05 5.00617E-05 None 0 2.24014E-05 None 3.12656E-05 0 8.47906E-06 1.09876E-05 0
R/C 22288 Ig-126 24 rs367665060 0.772 -0.036 1.0 N 0.765 0.511 None gnomAD-2.1.1 2.87E-05 None None None None I None 1.65536E-04 0 None 0 0 None 0 None 4.01E-05 2.35E-05 0
R/C 22288 Ig-126 24 rs367665060 0.772 -0.036 1.0 N 0.765 0.511 None gnomAD-3.1.2 5.26E-05 None None None None I None 1.4483E-04 0 0 0 0 None 1.88857E-04 0 0 0 0
R/C 22288 Ig-126 24 rs367665060 0.772 -0.036 1.0 N 0.765 0.511 None gnomAD-4.0.0 2.17031E-05 None None None None I None 1.3359E-04 0 None 0 2.23984E-05 None 3.12842E-05 0 1.69591E-05 0 3.20554E-05
R/H 22288 Ig-126 24 rs537871205 0.547 -1.085 1.0 N 0.741 0.464 0.454426139905 gnomAD-2.1.1 2.15E-05 None None None None I None 4.14E-05 0 None 0 0 None 6.54E-05 None 4.01E-05 7.85E-06 1.41203E-04
R/H 22288 Ig-126 24 rs537871205 0.547 -1.085 1.0 N 0.741 0.464 0.454426139905 gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 6.56E-05 0 0 0 None 9.43E-05 0 1.47E-05 0 0
R/H 22288 Ig-126 24 rs537871205 0.547 -1.085 1.0 N 0.741 0.464 0.454426139905 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
R/H 22288 Ig-126 24 rs537871205 0.547 -1.085 1.0 N 0.741 0.464 0.454426139905 gnomAD-4.0.0 1.17806E-05 None None None None I None 4.00128E-05 1.66817E-05 None 0 2.24054E-05 None 1.56377E-05 0 8.47945E-06 2.19684E-05 1.6021E-05
R/S 22288 Ig-126 24 None 0.9861 None 1.0 D 0.68 0.428 0.393159880135 gnomAD-4.0.0 1.36923E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31965E-05 0
R/C 23371 Ig-129 27 rs56141309 0.3681 0.07 1.0 N 0.63 0.47 0.743538347216 gnomAD-2.1.1 8.05E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
R/C 23371 Ig-129 27 rs56141309 0.3681 0.07 1.0 N 0.63 0.47 0.743538347216 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 23371 Ig-129 27 rs56141309 0.3681 0.07 1.0 N 0.63 0.47 0.743538347216 gnomAD-4.0.0 6.41267E-06 None None None None I None 0 3.39075E-05 None 0 0 None 0 0 7.18845E-06 0 0
R/H 23371 Ig-129 27 rs767208489 0.2036 -0.661 1.0 N 0.549 0.426 0.373537453441 gnomAD-2.1.1 8.05E-06 None None None None I None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 0 0
R/H 23371 Ig-129 27 rs767208489 0.2036 -0.661 1.0 N 0.549 0.426 0.373537453441 gnomAD-3.1.2 2.63E-05 None None None None I None 0 1.31096E-04 0 0 0 None 0 0 2.94E-05 0 0
R/H 23371 Ig-129 27 rs767208489 0.2036 -0.661 1.0 N 0.549 0.426 0.373537453441 gnomAD-4.0.0 9.92059E-06 None None None None I None 2.6713E-05 6.66956E-05 None 3.37998E-05 2.23075E-05 None 0 0 5.08821E-06 2.19664E-05 0
R/P 23371 Ig-129 27 rs767208489 0.9945 None 0.998 N 0.603 0.542 0.672494282746 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/P 23371 Ig-129 27 rs767208489 0.9945 None 0.998 N 0.603 0.542 0.672494282746 gnomAD-4.0.0 4.96029E-06 None None None None I None 2.6713E-05 0 None 0 0 None 0 0 5.08821E-06 0 0
R/S 23371 Ig-129 27 None 0.9257 None 0.993 N 0.578 0.405 0.489869231792 gnomAD-4.0.0 3.18647E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72502E-06 0 0
R/L 23660 Ig-130 24 rs570979108 0.4905 0.256 0.996 N 0.593 0.376 0.469578130381 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
R/L 23660 Ig-130 24 rs570979108 0.4905 0.256 0.996 N 0.593 0.376 0.469578130381 gnomAD-4.0.0 6.84727E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16144E-05 0
R/Q 23660 Ig-130 24 rs570979108 0.2107 -0.078 0.999 N 0.561 0.266 0.307332253619 gnomAD-2.1.1 2.84E-05 None None None None I None 0 0 None 0 3.41297E-04 None 0 None 0 8.98E-06 0
R/Q 23660 Ig-130 24 rs570979108 0.2107 -0.078 0.999 N 0.561 0.266 0.307332253619 gnomAD-4.0.0 2.67042E-05 None None None None I None 0 2.24044E-05 None 0 1.52084E-04 None 0 0 2.42963E-05 1.16136E-05 6.63152E-05
R/C 24056 Ig-131 28 rs372662393 0.2135 -0.19 1.0 D 0.669 0.462 None gnomAD-2.1.1 3.58E-05 None None None None I None 1.65453E-04 0 None 0 1.03681E-04 None 0 None 0 1.57E-05 2.81215E-04
R/C 24056 Ig-131 28 rs372662393 0.2135 -0.19 1.0 D 0.669 0.462 None gnomAD-3.1.2 1.05263E-04 None None None None I None 2.657E-04 1.31096E-04 0 0 0 None 0 0 2.94E-05 2.07641E-04 0
R/C 24056 Ig-131 28 rs372662393 0.2135 -0.19 1.0 D 0.669 0.462 None gnomAD-4.0.0 2.29346E-05 None None None None I None 2.53414E-04 3.33467E-05 None 0 4.47648E-05 None 0 0 8.47751E-06 2.1966E-05 3.20195E-05
R/G 24056 Ig-131 28 None 0.6509 None 0.975 N 0.565 0.396 0.714588635789 gnomAD-4.0.0 1.36877E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79918E-06 0 0
R/H 24056 Ig-131 28 rs398124455 0.123 -0.547 0.999 N 0.627 0.297 0.371903410333 gnomAD-2.1.1 2.54087E-04 None None None None I None 0 0 None 0 5.19E-05 None 2.2244E-03 None 0 7.83E-06 1.40726E-04
R/H 24056 Ig-131 28 rs398124455 0.123 -0.547 0.999 N 0.627 0.297 0.371903410333 gnomAD-3.1.2 4.6E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 1.24378E-03 0
R/H 24056 Ig-131 28 rs398124455 0.123 -0.547 0.999 N 0.627 0.297 0.371903410333 gnomAD-4.0.0 1.43185E-04 None None None None I None 0 0 None 0 2.23784E-05 None 1.56255E-05 0 1.35644E-05 2.24053E-03 1.44097E-04
R/L 24056 Ig-131 28 rs398124455 0.3236 0.345 0.975 N 0.565 0.366 0.669087604336 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/L 24056 Ig-131 28 rs398124455 0.3236 0.345 0.975 N 0.565 0.366 0.669087604336 gnomAD-4.0.0 3.42202E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49805E-06 0 0
R/S 24056 Ig-131 28 rs372662393 0.7283 None 0.975 N 0.631 0.278 0.464270400615 gnomAD-4.0.0 7.52824E-06 None None None None I None 0 0 None 0 0 None 0 0 9.8955E-06 0 0
R/G 24455 Ig-132 25 rs777909869 0.954 -0.238 1.0 D 0.657 0.492 0.72859088309 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/G 24455 Ig-132 25 rs777909869 0.954 -0.238 1.0 D 0.657 0.492 0.72859088309 gnomAD-4.0.0 1.59185E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85943E-06 0 0
R/K 24455 Ig-132 25 None 0.2519 None 0.997 N 0.5 0.321 0.351180957027 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 24742 Ig-133 27 rs369489704 0.3111 -0.262 0.017 N 0.397 0.31 None gnomAD-2.1.1 3.23E-05 None None None None I None 0 8.71E-05 None 0 0 None 6.54E-05 None 0 2.67E-05 0
R/C 24742 Ig-133 27 rs369489704 0.3111 -0.262 0.017 N 0.397 0.31 None gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 24742 Ig-133 27 rs369489704 0.3111 -0.262 0.017 N 0.397 0.31 None gnomAD-4.0.0 1.54978E-05 None None None None I None 1.33576E-05 5.00417E-05 None 0 0 None 0 0 1.10211E-05 7.68808E-05 1.60205E-05
R/H 24742 Ig-133 27 rs761823581 0.1624 -0.582 0.017 N 0.295 0.123 0.183819452728 gnomAD-2.1.1 1.79E-05 None None None None I None 1.24419E-04 0 None 0 0 None 0 None 0 1.57E-05 0
R/H 24742 Ig-133 27 rs761823581 0.1624 -0.582 0.017 N 0.295 0.123 0.183819452728 gnomAD-3.1.2 3.95E-05 None None None None I None 4.83E-05 1.3113E-04 0 0 0 None 0 0 2.94E-05 0 0
R/H 24742 Ig-133 27 rs761823581 0.1624 -0.582 0.017 N 0.295 0.123 0.183819452728 gnomAD-4.0.0 1.3019E-05 None None None None I None 4.00941E-05 6.67223E-05 None 0 2.23374E-05 None 0 0 1.10215E-05 0 0
K/Q 25138 Ig-134 28 rs1392761642 0.413 0.227 0.978 N 0.678 0.487 0.355242300401 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/Q 25138 Ig-134 28 rs1392761642 0.413 0.227 0.978 N 0.678 0.487 0.355242300401 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/R 25138 Ig-134 28 rs376597438 0.1238 0.08 0.085 N 0.351 0.18 None gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/R 25138 Ig-134 28 rs376597438 0.1238 0.08 0.085 N 0.351 0.18 None gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
K/R 25138 Ig-134 28 rs376597438 0.1238 0.08 0.085 N 0.351 0.18 None gnomAD-4.0.0 2.54095E-05 None None None None I None 1.33326E-05 0 None 0 0 None 0 0 3.30616E-05 0 1.60087E-05
R/C 25537 Ig-135 24 rs527631472 0.4251 -0.196 1.0 N 0.67 0.474 0.608244025668 gnomAD-2.1.1 8.07E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 8.91E-06 0
R/C 25537 Ig-135 24 rs527631472 0.4251 -0.196 1.0 N 0.67 0.474 0.608244025668 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 25537 Ig-135 24 rs527631472 0.4251 -0.196 1.0 N 0.67 0.474 0.608244025668 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/C 25537 Ig-135 24 rs527631472 0.4251 -0.196 1.0 N 0.67 0.474 0.608244025668 gnomAD-4.0.0 3.10092E-06 None None None None I None 0 0 None 0 2.23594E-05 None 0 0 2.54424E-06 1.09965E-05 0
R/G 25537 Ig-135 24 rs527631472 0.9404 -0.288 0.998 D 0.583 0.468 0.613844073566 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
R/G 25537 Ig-135 24 rs527631472 0.9404 -0.288 0.998 D 0.583 0.468 0.613844073566 gnomAD-4.0.0 2.05425E-06 None None None None I None 0 0 None 0 0 None 0 0 0 3.48303E-05 0
R/H 25537 Ig-135 24 rs561977468 0.2308 -0.542 0.783 D 0.425 0.318 None gnomAD-2.1.1 1.397E-04 None None None None I None 1.65412E-04 0 None 0 1.60074E-03 None 0 None 0 2.35E-05 1.41283E-04
R/H 25537 Ig-135 24 rs561977468 0.2308 -0.542 0.783 D 0.425 0.318 None gnomAD-3.1.2 8.55E-05 None None None None I None 1.20703E-04 0 0 0 9.67867E-04 None 0 0 4.41E-05 0 0
R/H 25537 Ig-135 24 rs561977468 0.2308 -0.542 0.783 D 0.425 0.318 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
R/H 25537 Ig-135 24 rs561977468 0.2308 -0.542 0.783 D 0.425 0.318 None gnomAD-4.0.0 4.65074E-05 None None None None I None 1.20131E-04 1.66939E-05 None 0 6.25978E-04 None 0 1.65344E-04 2.28965E-05 4.39754E-05 8.01E-05
R/C 25824 Ig-136 27 rs778684474 0.3048 -0.137 0.999 D 0.524 0.501 0.732132420435 gnomAD-2.1.1 2.02E-05 None None None None I None 0 0 None 0 5.59E-05 None 6.54E-05 None 0 1.79E-05 0
R/C 25824 Ig-136 27 rs778684474 0.3048 -0.137 0.999 D 0.524 0.501 0.732132420435 gnomAD-4.0.0 2.19E-05 None None None None I None 0 0 None 0 5.04566E-05 None 0 0 1.07954E-05 1.85567E-04 3.31433E-05
R/H 25824 Ig-136 27 rs376051922 0.1834 -0.542 0.016 N 0.261 0.1 None gnomAD-2.1.1 2.51E-05 None None None None I None 0 0 None 0 0 None 0 None 0 5.5E-05 0
R/H 25824 Ig-136 27 rs376051922 0.1834 -0.542 0.016 N 0.261 0.1 None gnomAD-3.1.2 3.95E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 7.36E-05 0 0
R/H 25824 Ig-136 27 rs376051922 0.1834 -0.542 0.016 N 0.261 0.1 None gnomAD-4.0.0 4.40115E-05 None None None None I None 1.3359E-05 0 None 0 2.23184E-05 None 0 0 5.68009E-05 1.09823E-05 1.60169E-05
R/L 25824 Ig-136 27 rs376051922 0.5462 0.37 0.846 D 0.575 0.325 0.587417723555 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
R/L 25824 Ig-136 27 rs376051922 0.5462 0.37 0.846 D 0.575 0.325 0.587417723555 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/L 25824 Ig-136 27 rs376051922 0.5462 0.37 0.846 D 0.575 0.325 0.587417723555 gnomAD-4.0.0 1.23976E-06 None None None None I None 0 0 None 0 0 None 1.56265E-05 0 8.47775E-07 0 0
R/C 26619 Ig-138 26 rs757229467 0.4947 -0.088 0.047 N 0.537 0.338 0.499727662827 gnomAD-2.1.1 3.62E-05 None None None None N None 0 5.8E-05 None 0 1.11408E-04 None 3.27E-05 None 0 3.55E-05 0
R/C 26619 Ig-138 26 rs757229467 0.4947 -0.088 0.047 N 0.537 0.338 0.499727662827 gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 4.77555E-04
R/C 26619 Ig-138 26 rs757229467 0.4947 -0.088 0.047 N 0.537 0.338 0.499727662827 gnomAD-4.0.0 1.23958E-05 None None None None N None 0 5.00417E-05 None 0 4.4603E-05 None 0 0 9.32439E-06 1.09801E-05 4.80384E-05
R/H 26619 Ig-138 26 rs530507211 0.2748 -0.82 0.047 D 0.291 0.235 0.202086224978 gnomAD-2.1.1 3.25466E-04 None None None None N None 0 2.11496E-03 None 0 5.57E-05 None 1.3071E-04 None 0 2.66E-05 0
R/H 26619 Ig-138 26 rs530507211 0.2748 -0.82 0.047 D 0.291 0.235 0.202086224978 gnomAD-3.1.2 3.95E-05 None None None None N None 0 2.62398E-04 0 0 0 None 0 0 2.94E-05 0 0
R/H 26619 Ig-138 26 rs530507211 0.2748 -0.82 0.047 D 0.291 0.235 0.202086224978 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
R/H 26619 Ig-138 26 rs530507211 0.2748 -0.82 0.047 D 0.291 0.235 0.202086224978 gnomAD-4.0.0 6.631E-05 None None None None N None 1.33323E-05 1.31715E-03 None 6.75721E-05 2.23025E-05 None 0 0 9.32448E-06 1.20778E-04 3.20164E-05
R/Q 26906 Ig-139 27 rs536183519 0.2015 -0.009 1.0 D 0.598 0.369 0.420322003156 gnomAD-2.1.1 2.86E-05 None None None None I None 1.2408E-04 2.83E-05 None 0 0 None 3.27E-05 None 0 2.34E-05 0
R/Q 26906 Ig-139 27 rs536183519 0.2015 -0.009 1.0 D 0.598 0.369 0.420322003156 gnomAD-3.1.2 2.63E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 2.07211E-04 0
R/Q 26906 Ig-139 27 rs536183519 0.2015 -0.009 1.0 D 0.598 0.369 0.420322003156 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
R/Q 26906 Ig-139 27 rs536183519 0.2015 -0.009 1.0 D 0.598 0.369 0.420322003156 gnomAD-4.0.0 1.85953E-05 None None None None I None 6.67254E-05 1.66778E-05 None 0 0 None 0 8.26173E-04 1.35636E-05 1.0988E-05 3.20225E-05
R/L 27702 Ig-141 27 None 0.6619 None 0.996 N 0.561 0.418 0.619139198567 gnomAD-4.0.0 1.36855E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31954E-05 0
R/Q 27702 Ig-141 27 rs776136653 0.2568 -0.013 0.999 N 0.533 0.34 0.352048277211 gnomAD-2.1.1 2.01E-05 None None None None N None 0 1.15929E-04 None 0 0 None 0 None 0 0 1.65728E-04
R/Q 27702 Ig-141 27 rs776136653 0.2568 -0.013 0.999 N 0.533 0.34 0.352048277211 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 27702 Ig-141 27 rs776136653 0.2568 -0.013 0.999 N 0.533 0.34 0.352048277211 gnomAD-4.0.0 6.19771E-06 None None None None N None 0 1.0005E-04 None 0 0 None 0 1.64582E-04 2.54301E-06 0 0
R/K 27989 Ig-142 27 rs1419715288 0.2241 0.265 0.944 N 0.495 0.235 0.394230963961 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.95E-06 0
R/K 27989 Ig-142 27 rs1419715288 0.2241 0.265 0.944 N 0.495 0.235 0.394230963961 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/K 27989 Ig-142 27 rs1419715288 0.2241 0.265 0.944 N 0.495 0.235 0.394230963961 gnomAD-4.0.0 2.56458E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78888E-06 0 0
R/Q 28384 Ig-143 27 rs1465916943 0.1537 0.207 0.999 N 0.626 0.305 0.317667799068 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 9.96E-05 0 None 0 None 0 8.91E-06 0
R/Q 28384 Ig-143 27 rs1465916943 0.1537 0.207 0.999 N 0.626 0.305 0.317667799068 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/Q 28384 Ig-143 27 rs1465916943 0.1537 0.207 0.999 N 0.626 0.305 0.317667799068 gnomAD-4.0.0 8.05636E-06 None None None None I None 4.00545E-05 0 None 3.37861E-05 0 None 1.56265E-05 0 6.78089E-06 0 0
R/G 29866 Ig-147 25 rs1346127107 0.9751 -0.198 1.0 N 0.643 0.504 0.560190409015 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 0 None 5.8E-05 0 0
R/G 29866 Ig-147 25 rs1346127107 0.9751 -0.198 1.0 N 0.643 0.504 0.560190409015 gnomAD-4.0.0 1.60673E-06 None None None None I None 0 0 None 0 0 None 2.12152E-05 0 0 0 0
R/K 29866 Ig-147 25 None 0.3807 None 0.997 N 0.517 0.278 0.489589578638 gnomAD-4.0.0 1.60661E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85845E-06 0 0
R/S 30553 Ig-149 22 rs1257917653 0.9058 -0.176 1.0 N 0.677 0.336 0.31291088546 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
R/S 30553 Ig-149 22 rs1257917653 0.9058 -0.176 1.0 N 0.677 0.336 0.31291088546 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 30553 Ig-149 22 rs1257917653 0.9058 -0.176 1.0 N 0.677 0.336 0.31291088546 gnomAD-4.0.0 6.57177E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
R/C 31242 Ig-151 25 rs563887822 0.3033 -0.094 1.0 N 0.761 0.47 0.637288232684 gnomAD-2.1.1 3.21E-05 None None None None I None 4.13E-05 0 None 0 0 None 3.27E-05 None 0 5.47E-05 0
R/C 31242 Ig-151 25 rs563887822 0.3033 -0.094 1.0 N 0.761 0.47 0.637288232684 gnomAD-3.1.2 4.6E-05 None None None None I None 2.41E-05 0 0 0 1.92678E-04 None 0 0 5.88E-05 2.07125E-04 0
R/C 31242 Ig-151 25 rs563887822 0.3033 -0.094 1.0 N 0.761 0.47 0.637288232684 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
R/C 31242 Ig-151 25 rs563887822 0.3033 -0.094 1.0 N 0.761 0.47 0.637288232684 gnomAD-4.0.0 4.2756E-05 None None None None I None 1.33273E-05 0 None 0 2.22955E-05 None 0 0 5.00071E-05 4.39252E-05 6.40205E-05
R/H 31242 Ig-151 25 rs369899675 0.1898 -0.805 1.0 D 0.765 0.434 None gnomAD-2.1.1 9.64E-05 None None None None I None 4.13E-05 2.83E-05 None 0 1.18009E-03 None 0 None 0 1.56E-05 0
R/H 31242 Ig-151 25 rs369899675 0.1898 -0.805 1.0 D 0.765 0.434 None gnomAD-3.1.2 6.58E-05 None None None None I None 4.83E-05 6.56E-05 0 0 5.78481E-04 None 0 0 2.94E-05 0 9.56938E-04
R/H 31242 Ig-151 25 rs369899675 0.1898 -0.805 1.0 D 0.765 0.434 None gnomAD-4.0.0 4.4E-05 None None None None I None 5.34245E-05 3.33567E-05 None 0 5.79555E-04 None 0 3.28947E-04 2.8818E-05 0 4.80323E-05
R/L 31242 Ig-151 25 rs369899675 0.5154 None 1.0 N 0.639 0.463 0.598660209896 gnomAD-4.0.0 6.84195E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99437E-07 0 0
K/R 31642 Ig-152 22 None 0.1358 None 0.999 N 0.652 0.335 0.399449838166 gnomAD-4.0.0 1.36843E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99489E-07 1.15937E-05 0
R/C 32333 Ig-154 27 rs368918455 0.2451 -0.084 1.0 N 0.671 0.412 None gnomAD-2.1.1 7.17E-06 None None None None I None 8.28E-05 0 None 0 0 None 0 None 0 0 0
R/C 32333 Ig-154 27 rs368918455 0.2451 -0.084 1.0 N 0.671 0.412 None gnomAD-3.1.2 2.63E-05 None None None None I None 9.66E-05 0 0 0 0 None 0 0 0 0 0
R/C 32333 Ig-154 27 rs368918455 0.2451 -0.084 1.0 N 0.671 0.412 None gnomAD-4.0.0 6.19715E-06 None None None None I None 5.34074E-05 0 None 0 2.22836E-05 None 0 0 4.23813E-06 0 0
R/H 32333 Ig-154 27 rs138846756 0.1599 -0.661 1.0 N 0.513 0.324 None gnomAD-2.1.1 4.26594E-04 None None None None I None 3.80763E-03 5.65835E-04 None 0 0 None 3.27E-05 None 0 3.94E-05 1.40687E-04
R/H 32333 Ig-154 27 rs138846756 0.1599 -0.661 1.0 N 0.513 0.324 None gnomAD-3.1.2 9.40406E-04 None None None None I None 3.3095E-03 3.27654E-04 0 0 0 None 0 0 1.47E-05 0 0
R/H 32333 Ig-154 27 rs138846756 0.1599 -0.661 1.0 N 0.513 0.324 None 1000 genomes 1.19808E-03 None None None None I None 4.5E-03 0 None None 0 0 None None None 0 None
R/H 32333 Ig-154 27 rs138846756 0.1599 -0.661 1.0 N 0.513 0.324 None gnomAD-4.0.0 2.21846E-04 None None None None I None 3.25377E-03 4.33333E-04 None 0 0 None 0 0 6.01805E-05 2.19616E-05 2.40077E-04
R/K 33127 Ig-156 27 rs1205888266 0.2654 0.092 0.067 N 0.405 0.204 0.322230723748 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/K 33127 Ig-156 27 rs1205888266 0.2654 0.092 0.067 N 0.405 0.204 0.322230723748 gnomAD-4.0.0 1.59159E-06 None None None None I None 0 2.2876E-05 None 0 0 None 0 0 0 0 0
R/S 33127 Ig-156 27 rs747615650 0.8997 -0.105 0.978 N 0.627 0.35 0.28798054836 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 8.88E-06 0
R/S 33127 Ig-156 27 rs747615650 0.8997 -0.105 0.978 N 0.627 0.35 0.28798054836 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/S 33127 Ig-156 27 rs747615650 0.8997 -0.105 0.978 N 0.627 0.35 0.28798054836 gnomAD-4.0.0 3.0988E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69529E-06 3.29504E-05 0
R/C 33223 Ig-157 21 rs1367376217 0.5482 -1.861 1.0 N 0.762 0.515 0.822579953997 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.56E-05 0
R/C 33223 Ig-157 21 rs1367376217 0.5482 -1.861 1.0 N 0.762 0.515 0.822579953997 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 33223 Ig-157 21 rs1367376217 0.5482 -1.861 1.0 N 0.762 0.515 0.822579953997 gnomAD-4.0.0 2.47908E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69528E-06 1.09842E-05 1.60164E-05
R/H 33223 Ig-157 21 rs369081242 0.3383 -2.104 1.0 N 0.752 0.465 None gnomAD-2.1.1 8.04E-05 None None None None N None 1.93874E-04 8.7E-05 None 0 6.13497E-04 None 3.27E-05 None 0 1.77E-05 0
R/H 33223 Ig-157 21 rs369081242 0.3383 -2.104 1.0 N 0.752 0.465 None gnomAD-3.1.2 7.89E-05 None None None None N None 2.65572E-04 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 33223 Ig-157 21 rs369081242 0.3383 -2.104 1.0 N 0.752 0.465 None gnomAD-4.0.0 4.39996E-05 None None None None N None 2.79985E-04 5.0005E-05 None 0 4.45951E-05 None 0 0 2.79722E-05 2.19645E-05 1.60087E-04
H/D 33522 Ig-158 27 None 0.5424 None 0.468 N 0.481 0.304 0.311079019809 gnomAD-4.0.0 1.59207E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85953E-06 0 0
D/G 34163 Ig-160 27 None 0.6817 None 1.0 N 0.595 0.513 0.244539031024 gnomAD-4.0.0 6.84158E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99415E-07 0 0
D/N 34163 Ig-160 27 rs750297489 0.2832 -0.664 1.0 N 0.621 0.337 None gnomAD-2.1.1 7.14E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
D/N 34163 Ig-160 27 rs750297489 0.2832 -0.664 1.0 N 0.621 0.337 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/N 34163 Ig-160 27 rs750297489 0.2832 -0.664 1.0 N 0.621 0.337 None gnomAD-4.0.0 3.71792E-06 None None None None N None 4.0047E-05 0 None 0 0 None 0 0 2.54267E-06 0 0
D/Y 34163 Ig-160 27 rs750297489 0.8654 -0.341 1.0 N 0.758 0.57 0.239305524855 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
H/R 34284 Ig-161 27 rs879025670 0.6474 None 0.811 N 0.521 0.424 None gnomAD-4.0.0 1.59098E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85771E-06 0 0
I/V 34389 Ig-162 27 rs796349969 0.1319 None 0.022 N 0.234 0.098 0.437850553699 gnomAD-4.0.0 3.18283E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71716E-06 0 0
K/E 34968 Ig-163 27 None 0.7506 None 0.999 N 0.685 0.471 0.405839309607 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
K/N 34968 Ig-163 27 rs1274496471 0.8987 -0.493 1.0 N 0.754 0.272 0.212008924253 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
K/N 34968 Ig-163 27 rs1274496471 0.8987 -0.493 1.0 N 0.754 0.272 0.212008924253 gnomAD-4.0.0 2.73656E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59759E-06 0 0
E/K 35155 Ig-164 27 rs748014260 0.4156 0.014 0.997 D 0.683 0.454 0.512651460143 gnomAD-2.1.1 8.03E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
E/K 35155 Ig-164 27 rs748014260 0.4156 0.014 0.997 D 0.683 0.454 0.512651460143 gnomAD-4.0.0 6.84135E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29575E-06 3.47794E-05 0
A/T 35633 Ig-167 27 rs766681840 0.2704 None 1.0 N 0.755 0.326 0.465549362696 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/K 35728 Ig-168 27 rs764891218 0.201 0.76 0.852 N 0.506 0.309 None gnomAD-2.1.1 1.8E-05 None None None None I None 4.16E-05 0 None 0 0 None 0 None 0 3.14E-05 0
E/K 35728 Ig-168 27 rs764891218 0.201 0.76 0.852 N 0.506 0.309 None gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 35728 Ig-168 27 rs764891218 0.201 0.76 0.852 N 0.506 0.309 None gnomAD-4.0.0 1.48877E-05 None None None None I None 1.33572E-05 0 None 0 2.22965E-05 None 0 3.28839E-04 1.44213E-05 0 4.80708E-05
E/A 35923 Ig-169 27 rs2154129939 0.3148 None 0.174 N 0.487 0.248 0.384752662912 gnomAD-4.0.0 4.77332E-06 None None None -0.332(OBSL1) -0.496(OBSCN) N None 0 0 None 0 0 None 0 0 8.57334E-06 0 0
E/D 35923 Ig-169 27 None 0.2103 None 0.001 N 0.224 0.067 0.0884992946249 gnomAD-4.0.0 1.59116E-06 None None None -0.412(OBSL1) -0.415(OBSCN) N None 0 0 None 0 0 None 0 0 0 0 3.02371E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.