Structural position:

  • Domain Type: Fn3
  • Aligned Position: 23
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
A/V 15677 Fn3-1 21 None 0.1379 None 0.334 N 0.575 0.244 0.37262878642 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/I 15778 Fn3-2 21 rs778449192 0.1531 -0.09 0.984 D 0.532 0.378 0.384419519794 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/I 15778 Fn3-2 21 rs778449192 0.1531 -0.09 0.984 D 0.532 0.378 0.384419519794 gnomAD-4.0.0 3.1878E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72534E-06 0 0
T/S 15778 Fn3-2 21 rs1292014251 0.0887 -1.241 0.123 N 0.232 0.132 0.130388298395 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
T/S 15778 Fn3-2 21 rs1292014251 0.0887 -1.241 0.123 N 0.232 0.132 0.130388298395 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/S 15778 Fn3-2 21 rs1292014251 0.0887 -1.241 0.123 N 0.232 0.132 0.130388298395 gnomAD-4.0.0 3.84958E-06 None None None None N None 5.08182E-05 0 None 0 0 None 0 0 0 0 0
K/Q 15879 Fn3-3 21 rs2057553844 0.087 None 0.065 N 0.307 0.047 0.154104182512 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/Q 15879 Fn3-3 21 rs2057553844 0.087 None 0.065 N 0.307 0.047 0.154104182512 gnomAD-4.0.0 6.58345E-06 None None None None I None 2.41488E-05 0 None 0 0 None 0 0 0 0 0
T/S 16075 Fn3-4 21 rs773602170 0.0863 -1.521 0.022 N 0.189 0.068 0.149567049428 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 16075 Fn3-4 21 rs773602170 0.0863 -1.521 0.022 N 0.189 0.068 0.149567049428 gnomAD-4.0.0 1.59408E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4339E-05 0
T/I 16371 Fn3-6 21 None 0.1943 None 0.994 N 0.609 0.418 0.596538173739 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/R 16371 Fn3-6 21 None 0.1782 None 0.994 N 0.654 0.456 0.671773944551 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
T/A 16470 Fn3-7 21 None 0.1298 None 0.103 N 0.278 0.116 0.139678290688 gnomAD-4.0.0 1.20044E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31263E-06 0 0
T/P 16470 Fn3-7 21 None 0.8487 None 0.984 D 0.611 0.39 0.473065174198 gnomAD-4.0.0 2.40094E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62533E-06 0 0
T/R 16470 Fn3-7 21 rs1403110773 0.2656 -0.519 0.968 N 0.615 0.328 0.595757661845 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.93E-05 None 0 0 None 0 None 0 0 0
T/R 16470 Fn3-7 21 rs1403110773 0.2656 -0.519 0.968 N 0.615 0.328 0.595757661845 gnomAD-4.0.0 1.59644E-06 None None None None N None 0 2.2979E-05 None 0 0 None 0 0 0 0 0
N/H 16571 Fn3-8 21 None 0.0865 None None N 0.277 0.091 0.0297737177859 gnomAD-4.0.0 1.59337E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
A/P 16872 Fn3-11 21 rs727503619 0.9871 -0.193 0.999 N 0.813 0.374 0.264081493735 gnomAD-2.1.1 7.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
A/P 16872 Fn3-11 21 rs727503619 0.9871 -0.193 0.999 N 0.813 0.374 0.264081493735 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/P 16872 Fn3-11 21 rs727503619 0.9871 -0.193 0.999 N 0.813 0.374 0.264081493735 gnomAD-4.0.0 2.47996E-05 None None None None N None 0 1.66834E-05 None 0 0 None 0 0 3.30692E-05 0 0
A/V 16872 Fn3-11 21 rs748264576 0.2337 0.14 0.998 N 0.683 0.34 0.352476196916 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/V 16872 Fn3-11 21 rs748264576 0.2337 0.14 0.998 N 0.683 0.34 0.352476196916 gnomAD-4.0.0 1.59291E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
T/A 17067 Fn3-12 21 rs1045892065 0.1047 -1.08 0.64 N 0.466 0.122 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 17067 Fn3-12 21 rs1045892065 0.1047 -1.08 0.64 N 0.466 0.122 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/A 17067 Fn3-12 21 rs1045892065 0.1047 -1.08 0.64 N 0.466 0.122 None gnomAD-4.0.0 1.15436E-05 None None None None N None 0 0 None 0 0 None 0 0 2.15662E-05 0 0
T/I 17067 Fn3-12 21 None 0.1706 None 0.984 N 0.607 0.418 0.480497669815 gnomAD-4.0.0 2.40064E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 17167 Fn3-13 21 rs749322226 0.5343 0.229 1.0 N 0.823 0.458 0.541239005379 gnomAD-2.1.1 1.43E-05 None None None None N None 1.65412E-04 0 None 0 0 None 0 None 0 0 0
T/I 17167 Fn3-13 21 rs749322226 0.5343 0.229 1.0 N 0.823 0.458 0.541239005379 gnomAD-3.1.2 1.97E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 0 0 0
T/I 17167 Fn3-13 21 rs749322226 0.5343 0.229 1.0 N 0.823 0.458 0.541239005379 gnomAD-4.0.0 6.82039E-06 None None None None N None 1.4702E-04 0 None 0 0 None 0 0 0 0 0
K/E 17389 Fn3-14 21 rs779439447 0.3187 -1.29 0.996 N 0.47 0.36 0.272205846399 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/E 17389 Fn3-14 21 rs779439447 0.3187 -1.29 0.996 N 0.47 0.36 0.272205846399 gnomAD-4.0.0 1.5947E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
D/N 17882 Fn3-18 21 None 0.23 None 0.959 N 0.397 0.133 0.209622950755 gnomAD-4.0.0 4.79926E-06 None None None None N None 0 0 None 0 0 None 0 0 8.62589E-06 0 0
T/A 18085 Fn3-19 21 rs1274377339 0.1071 -1.259 0.101 N 0.32 0.147 0.311691414656 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
T/A 18085 Fn3-19 21 rs1274377339 0.1071 -1.259 0.101 N 0.32 0.147 0.311691414656 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/A 18085 Fn3-19 21 rs1274377339 0.1071 -1.259 0.101 N 0.32 0.147 0.311691414656 gnomAD-4.0.0 2.03046E-06 None None None None N None 3.49724E-05 0 None 0 0 None 0 0 0 0 0
G/E 18292 Fn3-21 21 None 0.2268 None 0.024 N 0.578 0.103 0.130388298395 gnomAD-4.0.0 1.6117E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45756E-05 0
G/R 18292 Fn3-21 21 rs377512675 0.2722 -1.219 0.055 N 0.695 0.099 0.316494231283 gnomAD-2.1.1 3.81E-05 None None None None N None 0 0 None 0 0 None 0 None 0 8.5E-05 0
G/R 18292 Fn3-21 21 rs377512675 0.2722 -1.219 0.055 N 0.695 0.099 0.316494231283 gnomAD-3.1.2 1.98E-05 None None None None N None 0 0 0 0 0 None 0 0 4.42E-05 0 0
G/R 18292 Fn3-21 21 rs377512675 0.2722 -1.219 0.055 N 0.695 0.099 0.316494231283 gnomAD-4.0.0 4.61092E-05 None None None None N None 0 0 None 0 0 None 0 0 6.12618E-05 0 3.22051E-05
S/C 18805 Fn3-24 22 rs759563590 0.1077 -0.419 0.999 N 0.721 0.481 0.520320716586 gnomAD-2.1.1 4.36E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.46E-06 0
S/C 18805 Fn3-24 22 rs759563590 0.1077 -0.419 0.999 N 0.721 0.481 0.520320716586 gnomAD-4.0.0 1.63838E-06 None None None None N None 0 0 None 0 0 None 0 0 2.91182E-06 0 0
S/F 18805 Fn3-24 22 rs759563590 0.2251 None 0.984 D 0.757 0.523 0.656847193988 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 18805 Fn3-24 22 rs759563590 0.2251 None 0.984 D 0.757 0.523 0.656847193988 gnomAD-4.0.0 6.57575E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47076E-05 0 0
S/P 18805 Fn3-24 22 rs767581453 0.9603 -0.28 0.984 D 0.713 0.444 0.431602765429 gnomAD-2.1.1 1.75E-05 None None None None N None 0 0 None 0 0 None 0 None 4.88E-05 1.89E-05 1.81884E-04
S/P 18805 Fn3-24 22 rs767581453 0.9603 -0.28 0.984 D 0.713 0.444 0.431602765429 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
S/P 18805 Fn3-24 22 rs767581453 0.9603 -0.28 0.984 D 0.713 0.444 0.431602765429 gnomAD-4.0.0 1.44338E-05 None None None None N None 0 0 None 0 0 None 4.75798E-05 0 4.86315E-06 0 1.74459E-04
S/Y 18805 Fn3-24 22 None 0.2143 None 0.995 N 0.768 0.493 0.642324679019 gnomAD-4.0.0 1.63838E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.09272E-05
N/K 18904 Fn3-25 21 None 0.8322 None 1.0 N 0.714 0.36 0.202086224978 gnomAD-4.0.0 1.5988E-06 None None None None N None 5.69541E-05 0 None 0 0 None 0 0 0 0 0
E/K 19008 Fn3-26 21 None 0.5129 None 0.999 N 0.603 0.37 0.37262878642 gnomAD-4.0.0 1.60466E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86812E-06 0 0
T/P 19204 Fn3-27 22 None 0.7115 None 0.997 N 0.777 0.448 0.512021964565 gnomAD-4.0.0 6.8612E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00812E-07 0 0
T/P 19304 Fn3-28 21 None 0.8854 None 0.966 N 0.45 0.397 0.457197642564 gnomAD-4.0.0 3.42283E-06 None None None None N None 0 0 None 0 0 None 0 0 4.499E-06 0 0
S/F 19500 Fn3-29 22 rs1465284889 0.452 -0.659 1.0 D 0.9 0.495 0.741150988799 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
S/F 19500 Fn3-29 22 rs1465284889 0.452 -0.659 1.0 D 0.9 0.495 0.741150988799 gnomAD-4.0.0 6.8451E-07 None None None None N None 0 2.23994E-05 None 0 0 None 0 0 0 0 0
T/I 19599 Fn3-30 21 rs367816473 0.1278 0.193 0.002 D 0.349 0.16 None gnomAD-2.1.1 4.29E-05 None None None None N None 4.54921E-04 2.84E-05 None 0 0 None 0 None 0 0 0
T/I 19599 Fn3-30 21 rs367816473 0.1278 0.193 0.002 D 0.349 0.16 None gnomAD-3.1.2 1.71012E-04 None None None None N None 5.31221E-04 1.96541E-04 0 0 0 None 0 0 0 0 4.79846E-04
T/I 19599 Fn3-30 21 rs367816473 0.1278 0.193 0.002 D 0.349 0.16 None gnomAD-4.0.0 2.78956E-05 None None None None N None 4.54193E-04 8.34168E-05 None 0 0 None 0 0 8.47761E-07 0 8.00897E-05
T/P 19897 Fn3-32 21 None 0.782 None 0.994 N 0.629 0.435 0.516827169674 gnomAD-4.0.0 3.19186E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.87439E-05 0
V/F 19997 Fn3-33 21 None 0.1691 None 0.989 N 0.539 0.278 0.673914265645 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 20192 Fn3-34 22 None 0.9677 None 0.492 N 0.543 0.371 0.423119698836 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85999E-06 0 0
S/F 20291 Fn3-35 21 None 0.1621 None 0.484 N 0.607 0.434 0.63162399683 gnomAD-4.0.0 1.60051E-06 None None None None N None 0 0 None 0 2.78956E-05 None 0 0 0 0 0
V/E 20391 Fn3-36 21 None 0.6459 None 1.0 N 0.806 0.455 0.648059144284 gnomAD-4.0.0 1.59391E-06 None None None None N None 0 2.29211E-05 None 0 0 None 0 0 0 0 0
C/F 20884 Fn3-39 21 rs773806020 0.0766 -1.08 0.007 N 0.397 0.027 0.393927044628 gnomAD-2.1.1 1.45E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.14E-05 0
C/F 20884 Fn3-39 21 rs773806020 0.0766 -1.08 0.007 N 0.397 0.027 0.393927044628 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
C/F 20884 Fn3-39 21 rs773806020 0.0766 -1.08 0.007 N 0.397 0.027 0.393927044628 gnomAD-4.0.0 1.15934E-05 None None None None N None 0 0 None 0 0 None 0 0 2.15479E-05 0 0
C/R 20884 Fn3-39 21 rs2154183548 0.0724 None None N 0.377 0.09 0.371344866733 gnomAD-4.0.0 2.74432E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59836E-06 0 0
V/G 20983 Fn3-40 21 None 0.4074 None 1.0 N 0.849 0.43 0.763021800361 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 20983 Fn3-40 21 rs878904625 0.2868 -0.193 0.997 N 0.592 0.358 0.615873902259 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
G/E 21084 Fn3-41 21 rs1342843033 0.2304 -0.873 0.062 N 0.629 0.091 0.0806252709748 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
G/E 21084 Fn3-41 21 rs1342843033 0.2304 -0.873 0.062 N 0.629 0.091 0.0806252709748 gnomAD-4.0.0 1.60416E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44084E-05 0
A/V 21386 Fn3-43 21 None 0.1643 None 0.103 N 0.436 0.136 0.361160317528 gnomAD-4.0.0 1.36897E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15966E-05 1.65755E-05
S/L 21580 Fn3-44 22 None 0.1102 None 0.002 N 0.359 0.244 0.585930602222 gnomAD-4.0.0 6.84394E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65706E-05
A/G 21679 Fn3-45 21 None 0.185 None 0.052 N 0.434 0.09 0.361758802978 gnomAD-4.0.0 1.59257E-06 None None None None N None 0 0 None 0 2.78645E-05 None 0 0 0 0 0
A/T 21679 Fn3-45 21 None 0.1045 None None N 0.447 0.03 0.242244723065 gnomAD-4.0.0 1.59257E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86005E-06 0 0
I/M 21777 Fn3-46 21 rs779897187 0.1171 -0.732 0.497 N 0.485 0.07 0.566737540366 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.71409E-04
I/M 21777 Fn3-46 21 rs779897187 0.1171 -0.732 0.497 N 0.485 0.07 0.566737540366 gnomAD-4.0.0 1.60484E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45586E-05 0
S/G 22075 Fn3-48 21 None 0.2478 None 0.904 N 0.49 0.274 0.286081765059 gnomAD-4.0.0 1.36935E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99649E-07 1.15961E-05 0
S/F 22176 Fn3-49 21 rs779303152 0.2839 -0.554 0.667 N 0.749 0.36 0.675528658969 gnomAD-2.1.1 3.34E-05 None None None None N None 6.78E-05 0 None 0 0 None 0 None 0 6.49E-05 0
S/F 22176 Fn3-49 21 rs779303152 0.2839 -0.554 0.667 N 0.749 0.36 0.675528658969 gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 1.02944E-04 0 0
S/F 22176 Fn3-49 21 rs779303152 0.2839 -0.554 0.667 N 0.749 0.36 0.675528658969 gnomAD-4.0.0 5.03502E-05 None None None None N None 1.33672E-05 0 None 0 0 None 0 0 6.62478E-05 0 3.21357E-05
G/S 22471 Fn3-51 21 None 0.0708 None None N 0.228 0.128 0.107399877778 gnomAD-4.0.0 1.59234E-06 None None None None N None 0 0 None 0 2.77886E-05 None 0 0 0 0 0
I/L 22861 Fn3-54 21 rs1575838768 0.0967 None 0.005 N 0.395 0.027 0.361360026772 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 22861 Fn3-54 21 rs1575838768 0.0967 None 0.005 N 0.395 0.027 0.361360026772 gnomAD-4.0.0 6.57393E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
I/T 22861 Fn3-54 21 None 0.1793 None 0.062 N 0.431 0.209 0.469660041277 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/G 23159 Fn3-56 21 rs1473805330 0.1205 None 0.201 N 0.494 0.099 0.20549828249 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94326E-04 None 0 0 0 0 0
S/G 23159 Fn3-56 21 rs1473805330 0.1205 None 0.201 N 0.494 0.099 0.20549828249 gnomAD-4.0.0 6.08947E-06 None None None None N None 0 0 None 0 2.28206E-04 None 0 0 0 4.69792E-05 1.02013E-04
S/I 23159 Fn3-56 21 None 0.1396 None 0.81 N 0.675 0.267 0.412849826617 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
S/R 23159 Fn3-56 21 None 0.6562 None 0.81 N 0.661 0.284 0.0954503805726 gnomAD-4.0.0 1.59193E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85935E-06 0 0
A/E 23552 Fn3-59 21 None 0.6044 None 0.994 N 0.772 0.382 0.393471546983 gnomAD-4.0.0 6.84263E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99546E-07 0 0
A/T 23552 Fn3-59 21 None 0.1366 None 0.958 N 0.679 0.278 0.270447802918 gnomAD-4.0.0 6.84269E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99546E-07 0 0
A/V 23552 Fn3-59 21 rs754742503 0.1969 0.205 0.142 N 0.398 0.179 0.257292322809 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
A/V 23552 Fn3-59 21 rs754742503 0.1969 0.205 0.142 N 0.398 0.179 0.257292322809 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
A/V 23552 Fn3-59 21 rs754742503 0.1969 0.205 0.142 N 0.398 0.179 0.257292322809 gnomAD-4.0.0 6.19752E-06 None None None None N None 0 0 None 0 0 None 0 0 8.4769E-07 9.88142E-05 0
S/G 23846 Fn3-61 21 rs763759336 0.0842 -1.167 0.896 N 0.455 0.191 0.285698343383 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/G 23846 Fn3-61 21 rs763759336 0.0842 -1.167 0.896 N 0.455 0.191 0.285698343383 gnomAD-4.0.0 2.73745E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59842E-06 0 0
S/N 23846 Fn3-61 21 rs760506346 0.1288 -0.955 0.896 D 0.526 0.231 0.298056030225 gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 2.7983E-04 None 6.55E-05 None 0 0 0
S/N 23846 Fn3-61 21 rs760506346 0.1288 -0.955 0.896 D 0.526 0.231 0.298056030225 gnomAD-4.0.0 1.43723E-05 None None None None N None 0 0 None 0 1.26167E-04 None 0 1.73671E-04 5.39786E-06 1.04394E-04 0
S/R 23846 Fn3-61 21 rs763759336 0.3744 None 0.938 N 0.626 0.25 0.337868961071 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
S/R 23846 Fn3-61 21 rs763759336 0.3744 None 0.938 N 0.626 0.25 0.337868961071 gnomAD-4.0.0 6.57341E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06954E-04 0
K/N 23944 Fn3-62 21 rs1449315408 0.473 None 0.005 N 0.186 0.078 0.132336055621 gnomAD-4.0.0 3.42169E-06 None None None None N None 0 0 None 0 2.52564E-05 None 0 0 0 0 6.62734E-05
C/S 24242 Fn3-64 21 None 0.1821 None 0.058 N 0.399 0.249 0.424430313326 gnomAD-4.0.0 1.86391E-06 None None None None N None 0 0 None 0 0 None 0 0 3.25203E-06 0 0
A/G 24343 Fn3-65 21 None 0.172 None 0.014 N 0.4 0.24 0.351180957027 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 24343 Fn3-65 21 rs72646895 0.1049 -1.392 0.514 N 0.448 0.141 0.231873229951 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/S 24343 Fn3-65 21 rs72646895 0.1049 -1.392 0.514 N 0.448 0.141 0.231873229951 gnomAD-4.0.0 1.36884E-06 None None None None N None 0 0 None 0 2.52729E-05 None 0 0 0 1.15947E-05 0
A/T 24343 Fn3-65 21 rs72646895 0.1165 -1.112 0.929 N 0.585 0.139 None gnomAD-2.1.1 3.57E-05 None None None None N None 4.14E-05 1.41555E-04 None 0 0 None 3.27E-05 None 0 1.56E-05 1.40805E-04
A/T 24343 Fn3-65 21 rs72646895 0.1165 -1.112 0.929 N 0.585 0.139 None gnomAD-3.1.2 1.71077E-04 None None None None N None 1.20761E-04 1.18126E-03 0 0 0 None 0 0 2.94E-05 2.07641E-04 0
A/T 24343 Fn3-65 21 rs72646895 0.1165 -1.112 0.929 N 0.585 0.139 None gnomAD-4.0.0 3.71961E-05 None None None None N None 1.2025E-04 3.83704E-04 None 0 6.70901E-05 None 0 0 1.44126E-05 6.58892E-05 3.20369E-05
T/R 24539 Fn3-66 21 rs890303676 0.2952 -0.664 0.989 D 0.532 0.327 0.346544149963 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/R 24539 Fn3-66 21 rs890303676 0.2952 -0.664 0.989 D 0.532 0.327 0.346544149963 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 24539 Fn3-66 21 rs890303676 0.2952 -0.664 0.989 D 0.532 0.327 0.346544149963 gnomAD-4.0.0 3.84515E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18202E-06 0 0
S/C 24636 Fn3-67 21 None 0.0793 None 1.0 N 0.686 0.405 0.455909487837 gnomAD-4.0.0 6.1593E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09623E-06 0 0
S/F 24636 Fn3-67 21 rs1708469401 0.1637 None 1.0 N 0.743 0.453 0.641966406657 gnomAD-4.0.0 3.42183E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49791E-06 0 0
Q/P 25026 Fn3-70 21 None 0.9111 None 0.856 N 0.515 0.376 0.294561560033 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 25225 Fn3-71 22 None 0.0963 None 0.811 N 0.615 0.266 0.484329738948 gnomAD-4.0.0 1.59241E-06 None None None None N None 0 0 None 0 2.78489E-05 None 0 0 0 0 0
V/A 25324 Fn3-72 21 rs1369489276 0.173 -2.074 0.91 N 0.394 0.222 0.527908583987 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 9.29E-05 0 0
V/A 25324 Fn3-72 21 rs1369489276 0.173 -2.074 0.91 N 0.394 0.222 0.527908583987 gnomAD-4.0.0 9.55079E-06 None None None None N None 0 0 None 0 0 None 1.12952E-04 0 0 0 0
V/L 25324 Fn3-72 21 None 0.1888 None 0.835 N 0.405 0.198 0.536616348568 gnomAD-4.0.0 1.59177E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
S/I 25718 Fn3-75 21 rs1439934941 0.1611 0.375 0.999 N 0.615 0.414 0.50685403127 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/I 25718 Fn3-75 21 rs1439934941 0.1611 0.375 0.999 N 0.615 0.414 0.50685403127 gnomAD-4.0.0 6.57748E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47115E-05 0 0
S/Y 25911 Fn3-76 22 rs772557856 0.25 -0.51 0.999 N 0.759 0.422 0.739747123138 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/Y 25911 Fn3-76 22 rs772557856 0.25 -0.51 0.999 N 0.759 0.422 0.739747123138 gnomAD-4.0.0 1.50582E-05 None None None None N None 0 0 None 0 0 None 0 0 1.88924E-05 0 1.65777E-05
Q/H 26108 Fn3-78 21 None 0.2714 None 0.794 N 0.53 0.211 0.168933306366 gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25002E-06 0 0
Q/R 26108 Fn3-78 21 rs370963021 0.1128 -0.318 0.001 N 0.207 0.131 None gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.13E-05 0
Q/R 26108 Fn3-78 21 rs370963021 0.1128 -0.318 0.001 N 0.207 0.131 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
Q/R 26108 Fn3-78 21 rs370963021 0.1128 -0.318 0.001 N 0.207 0.131 None gnomAD-4.0.0 3.84269E-05 None None None None N None 0 0 None 0 0 None 0 0 5.00166E-05 0 4.80415E-05
T/I 26307 Fn3-79 22 None 0.1073 None 0.055 N 0.445 0.183 0.376745185316 gnomAD-4.0.0 1.59938E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8732E-06 0 0
T/R 26307 Fn3-79 22 None 0.1795 None None N 0.275 0.212 0.481616744073 gnomAD-4.0.0 1.59938E-06 None None None None N None 0 0 None 0 2.77701E-05 None 0 0 0 0 0
C/Y 26406 Fn3-80 21 rs727505223 0.5682 None 0.97 N 0.746 0.349 0.789754116976 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
A/D 26507 Fn3-81 21 rs538057461 0.4671 -2.199 0.782 N 0.679 0.266 0.508046185061 gnomAD-2.1.1 1.08E-05 None None None None N None 0 5.66E-05 None 0 0 None 0 None 0 0 1.40607E-04
A/D 26507 Fn3-81 21 rs538057461 0.4671 -2.199 0.782 N 0.679 0.266 0.508046185061 gnomAD-3.1.2 7.89E-05 None None None None N None 0 7.87092E-04 0 0 0 None 0 0 0 0 0
A/D 26507 Fn3-81 21 rs538057461 0.4671 -2.199 0.782 N 0.679 0.266 0.508046185061 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
A/D 26507 Fn3-81 21 rs538057461 0.4671 -2.199 0.782 N 0.679 0.266 0.508046185061 gnomAD-4.0.0 2.69459E-05 None None None None N None 0 2.88145E-04 None 0 0 None 0 0 0 0 1.13766E-04
A/S 26507 Fn3-81 21 None 0.0821 None 0.038 N 0.481 0.056 0.0954503805726 gnomAD-4.0.0 1.36955E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79906E-06 0 0
A/T 26507 Fn3-81 21 rs554718474 0.084 -0.83 0.007 N 0.456 0.065 0.146414634003 gnomAD-2.1.1 1.43E-05 None None None None N None 0 5.66E-05 None 0 0 None 0 None 0 7.83E-06 1.40647E-04
A/T 26507 Fn3-81 21 rs554718474 0.084 -0.83 0.007 N 0.456 0.065 0.146414634003 gnomAD-3.1.2 7.89E-05 None None None None N None 0 7.86885E-04 0 0 0 None 0 0 0 0 0
A/T 26507 Fn3-81 21 rs554718474 0.084 -0.83 0.007 N 0.456 0.065 0.146414634003 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
A/T 26507 Fn3-81 21 rs554718474 0.084 -0.83 0.007 N 0.456 0.065 0.146414634003 gnomAD-4.0.0 1.55037E-05 None None None None N None 0 2.8339E-04 None 0 0 None 0 0 3.39075E-06 0 6.40451E-05
A/V 26507 Fn3-81 21 rs538057461 0.136 0.57 0.007 N 0.437 0.163 0.298403945805 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/V 26507 Fn3-81 21 rs538057461 0.136 0.57 0.007 N 0.437 0.163 0.298403945805 gnomAD-4.0.0 1.59444E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85891E-06 0 0
V/L 26703 Fn3-82 21 rs1288435749 0.1005 0.075 0.015 N 0.337 0.065 0.274366138417 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/L 26703 Fn3-82 21 rs1288435749 0.1005 0.075 0.015 N 0.337 0.065 0.274366138417 gnomAD-4.0.0 4.77584E-06 None None None None N None 0 6.86153E-05 None 0 0 None 0 0 0 0 0
M/K 26800 Fn3-83 21 None 0.1219 None 0.025 N 0.392 0.239 0.40218521252 gnomAD-4.0.0 6.84288E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
M/L 26800 Fn3-83 21 None 0.0959 None None N 0.112 0.133 0.319686207203 gnomAD-4.0.0 6.8429E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9958E-07 0 0
M/T 26800 Fn3-83 21 rs761384994 0.0749 -0.962 None N 0.24 0.228 0.519783508757 gnomAD-2.1.1 1.61E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 2.68E-05 0
M/T 26800 Fn3-83 21 rs761384994 0.0749 -0.962 None N 0.24 0.228 0.519783508757 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 26800 Fn3-83 21 rs761384994 0.0749 -0.962 None N 0.24 0.228 0.519783508757 gnomAD-4.0.0 2.54113E-05 None None None None N None 0 1.66761E-05 None 0 0 None 0 0 3.22134E-05 1.09789E-05 1.60169E-05
M/V 26800 Fn3-83 21 None 0.0762 None None N 0.125 0.223 0.238705975628 gnomAD-4.0.0 3.42145E-06 None None None None N None 0 0 None 0 0 None 0 0 4.4979E-06 0 0
S/P 26993 Fn3-84 22 None 0.9882 None 1.0 D 0.807 0.54 0.48461828368 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
Q/L 27092 Fn3-85 21 rs950280958 0.1313 0.637 0.062 N 0.502 0.167 0.405979908929 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
Q/L 27092 Fn3-85 21 rs950280958 0.1313 0.637 0.062 N 0.502 0.167 0.405979908929 gnomAD-4.0.0 1.59306E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.436E-05 0
A/T 27390 Fn3-87 22 rs1249245369 0.0771 -1.465 0.028 N 0.433 0.215 0.390687800842 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
A/T 27390 Fn3-87 22 rs1249245369 0.0771 -1.465 0.028 N 0.433 0.215 0.390687800842 gnomAD-4.0.0 1.36848E-06 None None None None N None 0 0 None 0 2.52067E-05 None 0 0 8.99505E-07 0 0
T/I 27489 Fn3-88 21 None 0.2086 None 0.125 N 0.373 0.318 0.349870743963 gnomAD-4.0.0 1.59119E-06 None None None None N None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
A/P 27590 Fn3-89 21 None 0.9553 None 0.896 N 0.719 0.329 0.462721901306 gnomAD-4.0.0 6.84278E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99515E-07 0 0
K/M 27883 Fn3-91 21 None 0.16 None 0.999 N 0.666 0.342 0.334659703779 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/N 27883 Fn3-91 21 rs878854337 0.4045 -0.971 0.896 N 0.39 0.13 0.21737058555 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.72E-05 None 0 0 None 0 None 0 0 0
K/N 27883 Fn3-91 21 rs878854337 0.4045 -0.971 0.896 N 0.39 0.13 0.21737058555 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/N 27883 Fn3-91 21 rs878854337 0.4045 -0.971 0.896 N 0.39 0.13 0.21737058555 gnomAD-4.0.0 5.12743E-06 None None None None N None 0 6.78426E-05 None 0 0 None 0 0 0 0 0
K/Q 28272 Fn3-94 21 rs1703583612 0.0961 None 0.662 N 0.36 0.19 0.17258766438 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78927E-04
K/Q 28272 Fn3-94 21 rs1703583612 0.0961 None 0.662 N 0.36 0.19 0.17258766438 gnomAD-4.0.0 4.95747E-06 None None None None N None 0 0 None 0 0 None 0 8.22098E-04 8.47581E-07 0 3.20215E-05
S/A 28471 Fn3-95 22 rs1185011450 0.0929 -0.955 0.061 N 0.179 0.113 0.226586394389 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/A 28471 Fn3-95 22 rs1185011450 0.0929 -0.955 0.061 N 0.179 0.113 0.226586394389 gnomAD-4.0.0 1.59153E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85816E-06 0 0
C/R 28570 Fn3-96 21 rs753342822 0.5303 -0.841 0.884 N 0.657 0.357 0.73279132044 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
C/R 28570 Fn3-96 21 rs753342822 0.5303 -0.841 0.884 N 0.657 0.357 0.73279132044 gnomAD-4.0.0 1.36853E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99465E-07 1.15945E-05 0
C/Y 28570 Fn3-96 21 rs1038148800 0.3685 -1.065 0.028 N 0.495 0.303 0.625633723092 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
C/Y 28570 Fn3-96 21 rs1038148800 0.3685 -1.065 0.028 N 0.495 0.303 0.625633723092 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
C/Y 28570 Fn3-96 21 rs1038148800 0.3685 -1.065 0.028 N 0.495 0.303 0.625633723092 gnomAD-4.0.0 1.8593E-06 None None None None N None 4.0062E-05 0 None 0 0 None 0 0 0 0 0
A/D 28671 Fn3-97 21 rs751444096 0.3906 -2.364 0.012 N 0.476 0.111 0.294918367191 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.79E-05 0
A/D 28671 Fn3-97 21 rs751444096 0.3906 -2.364 0.012 N 0.476 0.111 0.294918367191 gnomAD-4.0.0 6.84228E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19581E-06 2.31879E-05 0
A/S 28671 Fn3-97 21 rs1276618314 0.0728 -1.547 None N 0.119 0.114 0.0297737177859 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/S 28671 Fn3-97 21 rs1276618314 0.0728 -1.547 None N 0.119 0.114 0.0297737177859 gnomAD-4.0.0 3.18288E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 3.02389E-05
K/Q 29158 Fn3-100 22 rs759043788 0.0838 -0.671 0.036 N 0.373 0.112 0.15556083564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
K/Q 29158 Fn3-100 22 rs759043788 0.0838 -0.671 0.036 N 0.373 0.112 0.15556083564 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
S/P 29355 Fn3-102 21 rs768443497 0.9296 -0.303 0.927 N 0.688 0.451 0.305730143919 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
S/P 29355 Fn3-102 21 rs768443497 0.9296 -0.303 0.927 N 0.688 0.451 0.305730143919 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/P 29355 Fn3-102 21 rs768443497 0.9296 -0.303 0.927 N 0.688 0.451 0.305730143919 gnomAD-4.0.0 6.57039E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46972E-05 0 0
G/D 29754 Fn3-105 21 rs769191835 0.4874 -1.418 0.761 N 0.681 0.158 None gnomAD-2.1.1 1.44E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.15E-05 0
G/D 29754 Fn3-105 21 rs769191835 0.4874 -1.418 0.761 N 0.681 0.158 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 29754 Fn3-105 21 rs769191835 0.4874 -1.418 0.761 N 0.681 0.158 None gnomAD-4.0.0 1.36477E-05 None None None None N None 0 0 None 0 0 None 1.56372E-05 0 1.44212E-05 0 6.41046E-05
G/R 29754 Fn3-105 21 rs1208704177 0.3609 None 0.864 N 0.725 0.146 0.448300063881 gnomAD-4.0.0 1.59529E-06 None None None None N None 0 0 None 0 2.77716E-05 None 0 0 0 0 0
L/F 29953 Fn3-106 21 None 0.0671 None None N 0.156 0.098 0.28492961333 gnomAD-4.0.0 3.19124E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71781E-06 0 0
L/I 29953 Fn3-106 21 None 0.0637 None 0.004 N 0.323 0.06 0.281780670237 gnomAD-4.0.0 1.59562E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85891E-06 0 0
S/T 30050 Fn3-107 21 rs752534032 0.0713 -0.49 None N 0.193 0.108 0.0401082797425 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
S/T 30050 Fn3-107 21 rs752534032 0.0713 -0.49 None N 0.193 0.108 0.0401082797425 gnomAD-4.0.0 4.10501E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99433E-07 5.79656E-05 0
S/L 30245 Fn3-108 22 rs1407888645 0.2813 None 1.0 N 0.786 0.456 0.814184237618 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
K/T 30442 Fn3-110 21 rs370086155 0.3391 -1.048 0.98 N 0.545 0.463 None gnomAD-2.1.1 1.43E-05 None None None None N None 1.65344E-04 0 None 0 0 None 0 None 0 0 0
K/T 30442 Fn3-110 21 rs370086155 0.3391 -1.048 0.98 N 0.545 0.463 None gnomAD-3.1.2 5.92E-05 None None None None N None 2.17255E-04 0 0 0 0 None 0 0 0 0 0
K/T 30442 Fn3-110 21 rs370086155 0.3391 -1.048 0.98 N 0.545 0.463 None gnomAD-4.0.0 1.30159E-05 None None None None N None 2.67094E-04 0 None 0 0 None 0 0 0 0 1.60128E-05
W/S 30640 Fn3-111 22 None 0.2176 None 1.0 N 0.745 0.387 0.551798466036 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
T/I 30739 Fn3-112 21 None 0.1549 None 0.988 N 0.523 0.372 0.537402380065 gnomAD-4.0.0 1.59172E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02535E-05
E/G 30841 Fn3-113 21 rs761617318 0.2453 -1.968 0.984 N 0.599 0.374 0.392395365052 gnomAD-2.1.1 7.14E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
E/G 30841 Fn3-113 21 rs761617318 0.2453 -1.968 0.984 N 0.599 0.374 0.392395365052 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/G 30841 Fn3-113 21 rs761617318 0.2453 -1.968 0.984 N 0.599 0.374 0.392395365052 gnomAD-4.0.0 1.31423E-05 None None None None N None 4.82509E-05 0 None 0 0 None 0 0 0 0 0
E/Q 30841 Fn3-113 21 rs765241194 0.1392 -1.025 1.0 N 0.607 0.272 0.220303561663 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/Q 30841 Fn3-113 21 rs765241194 0.1392 -1.025 1.0 N 0.607 0.272 0.220303561663 gnomAD-4.0.0 1.5911E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
M/T 31036 Fn3-114 21 rs376942948 0.3152 -1.556 0.007 N 0.307 0.278 None gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 1.66963E-04 None 6.54E-05 None 0 1.78E-05 0
M/T 31036 Fn3-114 21 rs376942948 0.3152 -1.556 0.007 N 0.307 0.278 None gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 3.85654E-04 None 0 0 4.41E-05 2.07383E-04 0
M/T 31036 Fn3-114 21 rs376942948 0.3152 -1.556 0.007 N 0.307 0.278 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 1E-03 0 None None None 1E-03 None
M/T 31036 Fn3-114 21 rs376942948 0.3152 -1.556 0.007 N 0.307 0.278 None gnomAD-4.0.0 2.16874E-05 None None None None N None 0 0 None 0 1.55999E-04 None 0 0 9.32368E-06 6.5879E-05 1.76039E-04
R/C 31428 Fn3-117 21 rs190282707 0.1257 -1.298 1.0 N 0.772 0.384 0.717641377234 gnomAD-2.1.1 2.5E-05 None None None None N None 0 2.83E-05 None 0 2.04939E-04 None 0 None 0 7.82E-06 1.40489E-04
R/C 31428 Fn3-117 21 rs190282707 0.1257 -1.298 1.0 N 0.772 0.384 0.717641377234 gnomAD-3.1.2 3.94E-05 None None None None N None 4.83E-05 0 0 0 5.78258E-04 None 0 0 0 2.06868E-04 0
R/C 31428 Fn3-117 21 rs190282707 0.1257 -1.298 1.0 N 0.772 0.384 0.717641377234 gnomAD-4.0.0 1.05344E-05 None None None None N None 3.99936E-05 0 None 0 2.45164E-04 None 0 0 8.47646E-07 1.09791E-05 1.60067E-05
R/G 31428 Fn3-117 21 rs190282707 0.2802 -1.919 0.996 N 0.617 0.385 None gnomAD-2.1.1 1.07135E-04 None None None None N None 1.23987E-03 0 None 0 0 None 0 None 0 0 0
R/G 31428 Fn3-117 21 rs190282707 0.2802 -1.919 0.996 N 0.617 0.385 None gnomAD-3.1.2 2.76051E-04 None None None None N None 9.89764E-04 6.55E-05 0 0 0 None 0 0 0 0 0
R/G 31428 Fn3-117 21 rs190282707 0.2802 -1.919 0.996 N 0.617 0.385 None gnomAD-4.0.0 4.52359E-05 None None None None N None 9.06522E-04 3.33267E-05 None 0 0 None 0 0 0 0 4.802E-05
R/H 31428 Fn3-117 21 rs149375775 0.0882 -1.782 1.0 N 0.55 0.369 None gnomAD-2.1.1 2.78548E-04 None None None None N None 2.52108E-03 2.2627E-04 None 0 5.13E-05 None 0 None 0 3.91E-05 4.21585E-04
R/H 31428 Fn3-117 21 rs149375775 0.0882 -1.782 1.0 N 0.55 0.369 None gnomAD-3.1.2 8.74011E-04 None None None None N None 3.01612E-03 1.30959E-04 0 0 0 None 0 0 4.41E-05 0 1.43541E-03
R/H 31428 Fn3-117 21 rs149375775 0.0882 -1.782 1.0 N 0.55 0.369 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
R/H 31428 Fn3-117 21 rs149375775 0.0882 -1.782 1.0 N 0.55 0.369 None gnomAD-4.0.0 1.71026E-04 None None None None N None 2.93216E-03 1.83291E-04 None 0 2.22866E-05 None 0 1.65071E-04 2.37341E-05 1.09794E-05 2.24086E-04
R/S 31428 Fn3-117 21 None 0.3396 -1.715 0.992 N 0.573 0.401 None gnomAD-2.1.1 2.5E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 4.69E-05 0
R/S 31428 Fn3-117 21 None 0.3396 -1.715 0.992 N 0.573 0.401 None gnomAD-3.1.2 8.54E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47011E-04 0 4.78469E-04
R/S 31428 Fn3-117 21 None 0.3396 -1.715 0.992 N 0.573 0.401 None gnomAD-4.0.0 4.27603E-05 None None None None N None 5.34117E-05 0 None 0 0 None 0 0 5.25537E-05 0 4.80369E-05
I/M 31526 Fn3-118 21 None 0.0851 None 0.304 N 0.379 0.034 0.474406357249 gnomAD-4.0.0 1.61651E-06 None None None None N None 0 0 None 0 0 None 0 0 2.91957E-06 0 0
I/V 31526 Fn3-118 21 rs534055493 0.0755 -0.943 None N 0.084 0.051 0.316198179892 gnomAD-2.1.1 1.23E-05 None None None None N None 0 0 None 0 1.68067E-04 None 0 None 0 0 0
I/V 31526 Fn3-118 21 rs534055493 0.0755 -0.943 None N 0.084 0.051 0.316198179892 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92678E-04 None 0 0 0 0 0
I/V 31526 Fn3-118 21 rs534055493 0.0755 -0.943 None N 0.084 0.051 0.316198179892 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
I/V 31526 Fn3-118 21 rs534055493 0.0755 -0.943 None N 0.084 0.051 0.316198179892 gnomAD-4.0.0 3.89599E-06 None None None None N None 0 0 None 0 7.32637E-05 None 0 0 0 0 0
A/S 31728 Fn3-119 21 rs1360534996 0.0726 None 0.025 N 0.331 0.077 0.184867976434 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 31728 Fn3-119 21 rs1360534996 0.0726 None 0.025 N 0.331 0.077 0.184867976434 gnomAD-4.0.0 6.57004E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
A/T 31728 Fn3-119 21 None 0.0729 None 0.698 N 0.467 0.102 0.313818047136 gnomAD-4.0.0 3.18359E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7186E-06 0 0
T/P 32125 Fn3-122 21 rs1295778602 0.7681 -0.783 1.0 N 0.825 0.46 0.376570364461 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
T/P 32125 Fn3-122 21 rs1295778602 0.7681 -0.783 1.0 N 0.825 0.46 0.376570364461 gnomAD-4.0.0 1.61175E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86033E-06 0 0
A/P 32222 Fn3-123 21 None 0.9142 None 0.996 N 0.542 0.342 0.482936932564 gnomAD-4.0.0 6.84179E-07 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 0 0 0
A/T 32222 Fn3-123 21 None 0.0847 None 0.959 N 0.467 0.266 0.339793275041 gnomAD-4.0.0 6.84179E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6564E-05
S/F 32420 Fn3-124 22 rs1393812138 0.3386 None 1.0 D 0.895 0.442 0.793893798558 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/N 32519 Fn3-125 21 rs762862711 0.1757 -1.041 1.0 N 0.743 0.306 0.460703734027 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
T/N 32519 Fn3-125 21 rs762862711 0.1757 -1.041 1.0 N 0.743 0.306 0.460703734027 gnomAD-4.0.0 4.77925E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58354E-06 0 0
A/V 32620 Fn3-126 21 rs397517772 0.3752 -0.216 0.999 N 0.637 0.325 0.547766246091 gnomAD-2.1.1 2.39077E-04 None None None None N None 0 0 None 5.12275E-03 0 None 0 None 0 7.03E-05 7.0205E-04
A/V 32620 Fn3-126 21 rs397517772 0.3752 -0.216 0.999 N 0.637 0.325 0.547766246091 gnomAD-3.1.2 1.51212E-04 None None None None N None 2.41E-05 6.55E-05 0 4.61361E-03 0 None 0 0 5.88E-05 0 4.79386E-04
A/V 32620 Fn3-126 21 rs397517772 0.3752 -0.216 0.999 N 0.637 0.325 0.547766246091 gnomAD-4.0.0 1.4192E-04 None None None None N None 1.33554E-05 1.66689E-05 None 4.69658E-03 0 None 0 0 5.34025E-05 0 4.0032E-04
S/N 32816 Fn3-127 22 rs773294476 0.3176 -0.917 0.994 N 0.6 0.314 0.318252033908 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/N 32816 Fn3-127 22 rs773294476 0.3176 -0.917 0.994 N 0.6 0.314 0.318252033908 gnomAD-4.0.0 3.18246E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71631E-06 0 0
S/F 32917 Fn3-128 22 rs561932256 0.2867 -0.464 0.999 N 0.773 0.384 None gnomAD-2.1.1 2.81E-05 None None None None N None 1.93748E-04 5.8E-05 None 0 0 None 0 None 0 8.87E-06 1.65508E-04
S/F 32917 Fn3-128 22 rs561932256 0.2867 -0.464 0.999 N 0.773 0.384 None gnomAD-3.1.2 3.94E-05 None None None None N None 1.44844E-04 0 0 0 0 None 0 0 0 0 0
S/F 32917 Fn3-128 22 rs561932256 0.2867 -0.464 0.999 N 0.773 0.384 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
S/F 32917 Fn3-128 22 rs561932256 0.2867 -0.464 0.999 N 0.773 0.384 None gnomAD-4.0.0 1.73505E-05 None None None None N None 1.86637E-04 3.33311E-05 None 0 0 None 0 0 5.9334E-06 1.09798E-05 6.40225E-05
Q/E 33018 Fn3-129 21 rs1384790834 0.1024 -0.989 0.005 N 0.171 0.17 0.158396225186 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/E 33018 Fn3-129 21 rs1384790834 0.1024 -0.989 0.005 N 0.171 0.17 0.158396225186 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
Q/E 33018 Fn3-129 21 rs1384790834 0.1024 -0.989 0.005 N 0.171 0.17 0.158396225186 gnomAD-4.0.0 6.40668E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39336E-06 5.36164E-05 0
Q/H 33018 Fn3-129 21 rs1347129449 0.167 -1.057 0.005 N 0.173 0.103 0.154104182512 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
Q/H 33018 Fn3-129 21 rs1347129449 0.167 -1.057 0.005 N 0.173 0.103 0.154104182512 gnomAD-4.0.0 1.59155E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85874E-06 0 0
A/S 33412 Fn3-131 21 None 0.0812 None None N 0.162 0.06 0.166414681773 gnomAD-4.0.0 7.16524E-07 None None None None N None 0 0 None 0 0 None 0 0 9.24503E-07 0 0
A/T 33412 Fn3-131 21 rs778297512 0.0831 -1.341 None N 0.175 0.046 0.264081493735 gnomAD-2.1.1 5.13E-06 None None None None N None 0 3.74E-05 None 0 0 None 0 None 0 0 0
A/T 33412 Fn3-131 21 rs778297512 0.0831 -1.341 None N 0.175 0.046 0.264081493735 gnomAD-4.0.0 7.16523E-07 None None None None N None 0 2.77408E-05 None 0 0 None 0 0 0 0 0
T/I 33709 Fn3-132 21 None 0.1623 None 0.995 N 0.551 0.293 0.377274123778 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79888E-06 0 0
T/K 33709 Fn3-132 21 None 0.3224 None 0.965 N 0.407 0.237 0.284539287134 gnomAD-4.0.0 6.84201E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99442E-07 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.