Structural position:

  • Domain Type: Fn3
  • Aligned Position: 28
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
L/S 15682 Fn3-1 26 None 0.089 None 0.801 N 0.327 0.15 0.504418060211 gnomAD-4.0.0 1.59392E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.03122E-05
L/P 15884 Fn3-3 26 rs1167024702 0.3495 -0.051 1.0 N 0.707 0.572 0.587751488883 gnomAD-2.1.1 8.74E-06 None None None None I None 0 0 None 0 0 None 0 None 9.47E-05 0 0
L/P 15884 Fn3-3 26 rs1167024702 0.3495 -0.051 1.0 N 0.707 0.572 0.587751488883 gnomAD-4.0.0 3.27201E-06 None None None None I None 0 0 None 0 0 None 3.78845E-05 0 0 0 0
D/G 16080 Fn3-4 26 rs775135961 0.1323 -0.237 0.117 N 0.428 0.146 0.278143212241 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/G 16080 Fn3-4 26 rs775135961 0.1323 -0.237 0.117 N 0.428 0.146 0.278143212241 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 16080 Fn3-4 26 rs775135961 0.1323 -0.237 0.117 N 0.428 0.146 0.278143212241 gnomAD-4.0.0 5.13317E-06 None None None None N None 0 1.69739E-05 None 0 0 None 0 0 7.19259E-06 0 0
D/N 16080 Fn3-4 26 rs1397418209 0.0923 0.54 0.117 N 0.462 0.133 0.280181792013 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/N 16080 Fn3-4 26 rs1397418209 0.0923 0.54 0.117 N 0.462 0.133 0.280181792013 gnomAD-4.0.0 1.59397E-06 None None None None N None 0 0 None 0 2.78071E-05 None 0 0 0 0 0
K/E 16180 Fn3-5 26 rs759396669 0.2425 0.116 0.999 N 0.705 0.42 0.444102476654 gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 0 None 2.28833E-04 None 0 0 0
K/E 16180 Fn3-5 26 rs759396669 0.2425 0.116 0.999 N 0.705 0.42 0.444102476654 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
K/E 16180 Fn3-5 26 rs759396669 0.2425 0.116 0.999 N 0.705 0.42 0.444102476654 gnomAD-4.0.0 1.41122E-05 None None None None N None 0 0 None 0 0 None 0 2.24921E-04 2.39716E-06 1.20673E-04 0
R/C 16376 Fn3-6 26 rs772152172 0.5058 -0.192 1.0 N 0.78 0.371 0.547212138244 gnomAD-2.1.1 3.59E-05 None None None None N None 0 5.67E-05 None 0 3.11397E-04 None 0 None 0 1.57E-05 0
R/C 16376 Fn3-6 26 rs772152172 0.5058 -0.192 1.0 N 0.78 0.371 0.547212138244 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 1.95389E-04 None 0 0 0 0 0
R/C 16376 Fn3-6 26 rs772152172 0.5058 -0.192 1.0 N 0.78 0.371 0.547212138244 gnomAD-4.0.0 1.79842E-05 None None None None N None 0 3.3399E-05 None 0 1.56838E-04 None 3.12666E-05 0 1.27198E-05 1.09823E-05 3.20554E-05
R/H 16376 Fn3-6 26 rs746306518 0.3495 -0.518 1.0 N 0.782 0.385 0.330331372229 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
R/H 16376 Fn3-6 26 rs746306518 0.3495 -0.518 1.0 N 0.782 0.385 0.330331372229 gnomAD-4.0.0 1.43767E-05 None None None None N None 0 0 None 0 2.53113E-05 None 0 0 1.70963E-05 0 1.65832E-05
D/N 16475 Fn3-7 26 rs1246365092 0.141 0.638 1.0 N 0.669 0.298 0.252162846088 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/N 16475 Fn3-7 26 rs1246365092 0.141 0.638 1.0 N 0.669 0.298 0.252162846088 gnomAD-4.0.0 4.79447E-06 None None None None I None 0 0 None 0 0 None 0 0 6.30071E-06 0 0
E/G 16676 Fn3-9 26 None 0.3854 None 1.0 N 0.647 0.469 0.460438652622 gnomAD-4.0.0 1.59497E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86251E-06 0 0
E/K 16676 Fn3-9 26 rs759582108 0.4735 0.665 0.999 N 0.667 0.322 0.383921772103 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
E/K 16676 Fn3-9 26 rs759582108 0.4735 0.665 0.999 N 0.667 0.322 0.383921772103 gnomAD-4.0.0 4.78506E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.30182E-05 0
E/G 16877 Fn3-11 26 None 0.2251 None 0.801 N 0.43 0.239 0.44307954383 gnomAD-4.0.0 1.5929E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86125E-06 0 0
E/Q 16877 Fn3-11 26 rs566364225 0.1921 0.378 0.136 N 0.205 0.155 0.245101548738 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 0
E/Q 16877 Fn3-11 26 rs566364225 0.1921 0.378 0.136 N 0.205 0.155 0.245101548738 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
E/Q 16877 Fn3-11 26 rs566364225 0.1921 0.378 0.136 N 0.205 0.155 0.245101548738 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
E/Q 16877 Fn3-11 26 rs566364225 0.1921 0.378 0.136 N 0.205 0.155 0.245101548738 gnomAD-4.0.0 5.12873E-06 None None None None I None 0 0 None 0 0 None 0 0 0 5.36193E-05 0
E/Q 17072 Fn3-12 26 rs1374988000 0.1931 0.042 0.946 N 0.485 0.199 0.334161072951 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/Q 17072 Fn3-12 26 rs1374988000 0.1931 0.042 0.946 N 0.485 0.199 0.334161072951 gnomAD-4.0.0 3.18644E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86223E-06 0 3.02939E-05
L/P 17394 Fn3-14 26 rs727503616 0.3141 None 1.0 N 0.709 0.347 0.590198699859 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/P 17394 Fn3-14 26 rs727503616 0.3141 None 1.0 N 0.709 0.347 0.590198699859 gnomAD-4.0.0 2.5666E-06 None None None None I None 3.38765E-05 0 None 0 0 None 0 0 0 0 0
A/G 17594 Fn3-16 26 rs1267329743 0.1517 None 0.815 N 0.202 0.101 0.210429274316 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/G 17594 Fn3-16 26 rs1267329743 0.1517 None 0.815 N 0.202 0.101 0.210429274316 gnomAD-4.0.0 6.57531E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47215E-05 0 0
A/V 17594 Fn3-16 26 rs1267329743 0.0904 None 0.003 N 0.068 0.159 0.206339911435 gnomAD-4.0.0 3.18648E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72269E-06 0 0
R/C 17887 Fn3-18 26 rs771307468 0.6213 -0.169 1.0 N 0.771 0.465 0.623225470471 gnomAD-4.0.0 1.5962E-06 None None None None I None 0 2.29032E-05 None 0 0 None 0 0 0 0 0
R/H 17887 Fn3-18 26 rs749310329 0.3937 -0.573 1.0 N 0.789 0.422 0.3349148499 gnomAD-2.1.1 1.21E-05 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 1.78E-05 0
R/H 17887 Fn3-18 26 rs749310329 0.3937 -0.573 1.0 N 0.789 0.422 0.3349148499 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/H 17887 Fn3-18 26 rs749310329 0.3937 -0.573 1.0 N 0.789 0.422 0.3349148499 gnomAD-4.0.0 5.58507E-06 None None None None I None 1.33783E-05 1.6695E-05 None 0 0 None 0 0 5.09144E-06 0 1.60364E-05
D/G 18504 Fn3-22 26 rs778267361 0.2909 -0.215 0.994 N 0.521 0.354 0.347217280506 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 0 0
D/G 18504 Fn3-22 26 rs778267361 0.2909 -0.215 0.994 N 0.521 0.354 0.347217280506 gnomAD-4.0.0 1.59296E-06 None None None None I None 0 0 None 0 2.77778E-05 None 0 0 0 0 0
D/Y 18504 Fn3-22 26 rs1254716057 0.4452 -0.067 0.999 D 0.645 0.325 0.356281029322 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 18504 Fn3-22 26 rs1254716057 0.4452 -0.067 0.999 D 0.645 0.325 0.356281029322 gnomAD-4.0.0 6.57557E-06 None None None None I None 2.41255E-05 0 None 0 0 None 0 0 0 0 0
E/K 18909 Fn3-25 26 rs1224434103 0.1419 0.541 0.116 N 0.111 0.239 0.244539031024 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.09E-06 0
E/K 18909 Fn3-25 26 rs1224434103 0.1419 0.541 0.116 N 0.111 0.239 0.244539031024 gnomAD-4.0.0 4.11078E-06 None None None None I None 0 0 None 0 0 None 0 0 5.40073E-06 0 0
L/P 19013 Fn3-26 26 rs991075111 0.2159 None 0.896 N 0.291 0.201 0.589813230912 gnomAD-4.0.0 3.43309E-06 None None None None I None 0 0 None 0 0 None 0 0 4.50202E-06 0 0
L/V 19013 Fn3-26 26 None 0.0767 -0.141 0.002 N 0.103 0.065 0.115124310173 gnomAD-2.1.1 4.11E-06 None None None None I None 0 0 None 1.00766E-04 0 None 0 None 0 0 0
L/V 19013 Fn3-26 26 None 0.0767 -0.141 0.002 N 0.103 0.065 0.115124310173 gnomAD-4.0.0 2.05983E-06 None None None None I None 0 0 None 7.6864E-05 0 None 0 0 0 0 1.66168E-05
E/D 19209 Fn3-27 27 rs769829057 0.1071 -0.019 0.006 N 0.3 0.083 0.266385636622 gnomAD-2.1.1 8.29E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.83E-05 0
E/D 19209 Fn3-27 27 rs769829057 0.1071 -0.019 0.006 N 0.3 0.083 0.266385636622 gnomAD-4.0.0 4.80402E-06 None None None None I None 0 0 None 0 0 None 0 0 6.30643E-06 0 0
K/M 19309 Fn3-28 26 None 0.5994 None 0.997 N 0.651 0.418 0.39619538035 gnomAD-4.0.0 6.8451E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99755E-07 0 0
K/R 19309 Fn3-28 26 None 0.1072 None 0.998 N 0.607 0.238 0.427829143865 gnomAD-4.0.0 2.05353E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79951E-06 1.16093E-05 0
R/C 19705 Fn3-31 26 rs72646839 0.3207 -0.044 1.0 N 0.366 0.351 None gnomAD-2.1.1 2.25274E-04 None None None None N None 1.24018E-04 4.24905E-04 None 3.87147E-04 0 None 0 None 0 3.05403E-04 2.81057E-04
R/C 19705 Fn3-31 26 rs72646839 0.3207 -0.044 1.0 N 0.366 0.351 None gnomAD-3.1.2 2.36873E-04 None None None None N None 1.20814E-04 1.96799E-04 0 0 0 None 0 0 4.11874E-04 0 0
R/C 19705 Fn3-31 26 rs72646839 0.3207 -0.044 1.0 N 0.366 0.351 None gnomAD-4.0.0 2.14462E-04 None None None None N None 9.33906E-05 4.0032E-04 None 3.04116E-04 0 None 1.5625E-05 0 2.46698E-04 0 2.24108E-04
R/H 19705 Fn3-31 26 rs727503590 0.2097 -0.591 0.999 N 0.416 0.333 0.398581233421 gnomAD-2.1.1 2.15E-05 None None None None N None 0 2.83E-05 None 0 0 None 3.27E-05 None 0 3.13E-05 0
R/H 19705 Fn3-31 26 rs727503590 0.2097 -0.591 0.999 N 0.416 0.333 0.398581233421 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 2.07727E-04 0
R/H 19705 Fn3-31 26 rs727503590 0.2097 -0.591 0.999 N 0.416 0.333 0.398581233421 gnomAD-4.0.0 1.6116E-05 None None None None N None 0 3.33578E-05 None 0 0 None 0 0 1.94979E-05 1.09827E-05 0
L/V 19902 Fn3-32 26 None 0.0686 None 0.771 N 0.375 0.08 0.241078983079 gnomAD-4.0.0 1.59503E-06 None None None None I None 0 0 None 0 0 None 0 0 2.863E-06 0 0
D/G 20002 Fn3-33 26 rs199512049 0.3672 -0.211 1.0 N 0.672 0.493 None gnomAD-2.1.1 5.5111E-04 None None None None N None 0 0 None 1.28801E-02 0 None 0 None 0 1.2538E-04 7.03829E-04
D/G 20002 Fn3-33 26 rs199512049 0.3672 -0.211 1.0 N 0.672 0.493 None gnomAD-3.1.2 3.09052E-04 None None None None N None 0 6.56E-05 0 1.0951E-02 0 None 0 0 1.02953E-04 0 4.77555E-04
D/G 20002 Fn3-33 26 rs199512049 0.3672 -0.211 1.0 N 0.672 0.493 None gnomAD-4.0.0 3.13045E-04 None None None None N None 2.67044E-05 3.33756E-05 None 1.26386E-02 0 None 0 0 6.01907E-05 0 8.96861E-04
D/H 20002 Fn3-33 26 None 0.472 None 1.0 N 0.635 0.442 0.449474494731 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 20197 Fn3-34 27 None 0.4358 None 0.993 N 0.711 0.266 0.301455362545 gnomAD-4.0.0 6.84413E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99653E-07 0 0
K/T 20197 Fn3-34 27 None 0.1517 None 0.993 N 0.657 0.281 0.400899426204 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/Q 20296 Fn3-35 26 rs755102239 0.1057 0.091 0.966 N 0.414 0.223 0.278968121808 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
K/Q 20296 Fn3-35 26 rs755102239 0.1057 0.091 0.966 N 0.414 0.223 0.278968121808 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/Q 20296 Fn3-35 26 rs755102239 0.1057 0.091 0.966 N 0.414 0.223 0.278968121808 gnomAD-4.0.0 6.57575E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47085E-05 0 0
L/P 20396 Fn3-36 26 None 0.2993 None 0.966 N 0.315 0.294 0.629339664297 gnomAD-4.0.0 2.73823E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59914E-06 0 0
L/R 20396 Fn3-36 26 rs2049986459 0.3401 None 0.934 N 0.323 0.216 0.57330664977 gnomAD-4.0.0 1.36912E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79957E-06 0 0
L/P 20594 Fn3-37 26 None 0.182 None 0.873 N 0.344 0.208 0.620567169836 gnomAD-4.0.0 2.73781E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59859E-06 0 0
L/Q 20594 Fn3-37 26 None 0.0995 None 0.029 N 0.279 0.142 0.497806138765 gnomAD-4.0.0 6.84452E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99646E-07 0 0
E/A 20988 Fn3-40 26 rs2049605788 0.125 None 0.989 N 0.575 0.338 0.380730819819 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.93949E-04 None 0 0 0 0 0
E/A 20988 Fn3-40 26 rs2049605788 0.125 None 0.989 N 0.575 0.338 0.380730819819 gnomAD-4.0.0 1.41002E-05 None None None None I None 0 0 None 0 2.67575E-04 None 0 0 0 0 0
E/K 21291 Fn3-42 26 None 0.1439 None 0.998 N 0.63 0.398 0.385578977469 gnomAD-4.0.0 6.94381E-07 None None None None N None 0 0 None 0 0 None 0 0 9.08772E-07 0 0
L/R 21391 Fn3-43 26 None 0.483 None 1.0 N 0.704 0.469 0.682517699708 gnomAD-4.0.0 1.59276E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
L/M 21585 Fn3-44 27 rs772957708 0.0928 -0.471 0.996 N 0.321 0.254 0.548103985532 gnomAD-2.1.1 4.03E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
D/A 21684 Fn3-45 26 rs1305056270 0.0844 0.104 0.064 N 0.189 0.181 0.251639045875 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/A 21684 Fn3-45 26 rs1305056270 0.0844 0.104 0.064 N 0.189 0.181 0.251639045875 gnomAD-4.0.0 1.59246E-06 None None None None I None 0 2.2877E-05 None 0 0 None 0 0 0 0 0
D/E 21684 Fn3-45 26 None 0.1044 None 0.679 N 0.329 0.122 0.315903272564 gnomAD-4.0.0 1.59247E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
D/G 21684 Fn3-45 26 rs1305056270 0.1291 0.002 0.679 N 0.317 0.188 0.230578612272 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.63E-05 None 0 None 0 0 0
D/G 21684 Fn3-45 26 rs1305056270 0.1291 0.002 0.679 N 0.317 0.188 0.230578612272 gnomAD-4.0.0 1.27397E-05 None None None None I None 0 0 None 0 2.22866E-04 None 0 0 0 0 0
D/V 21684 Fn3-45 26 None 0.1033 None 0.064 N 0.268 0.227 0.389126455913 gnomAD-4.0.0 1.59246E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
D/Y 21684 Fn3-45 26 None 0.1897 None 0.991 N 0.294 0.31 0.486282253068 gnomAD-4.0.0 1.59249E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43324E-05 0
L/F 21981 Fn3-47 26 rs1414709360 0.2222 -0.542 0.998 N 0.706 0.362 0.366277470483 gnomAD-2.1.1 7.16E-06 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 7.84E-06 0
L/F 21981 Fn3-47 26 rs1414709360 0.2222 -0.542 0.998 N 0.706 0.362 0.366277470483 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/F 21981 Fn3-47 26 rs1414709360 0.2222 -0.542 0.998 N 0.706 0.362 0.366277470483 gnomAD-4.0.0 3.72004E-06 None None None None N None 1.3359E-05 0 None 0 0 None 0 0 4.23967E-06 0 0
A/T 22080 Fn3-48 26 None 0.0747 None 0.565 N 0.41 0.143 0.290222751274 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/G 22181 Fn3-49 26 rs1187714227 0.3981 -0.136 0.979 N 0.638 0.292 0.289847578895 gnomAD-2.1.1 7.33E-06 None None None None I None 4.23E-05 0 None 0 0 None 0 None 0 8.05E-06 0
A/G 22181 Fn3-49 26 rs1187714227 0.3981 -0.136 0.979 N 0.638 0.292 0.289847578895 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/G 22181 Fn3-49 26 rs1187714227 0.3981 -0.136 0.979 N 0.638 0.292 0.289847578895 gnomAD-4.0.0 2.57455E-06 None None None None I None 1.69302E-05 0 None 0 0 None 0 0 2.40316E-06 0 0
A/T 22181 Fn3-49 26 None 0.2565 None 0.958 N 0.657 0.235 0.309839678437 gnomAD-4.0.0 6.86036E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16583E-05 0
I/T 22379 Fn3-50 26 None 0.1972 None 0.005 N 0.14 0.231 0.345859378078 gnomAD-4.0.0 4.79093E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29767E-06 0 0
H/N 22476 Fn3-51 26 None 0.0758 None 0.007 N 0.203 0.066 0.143124449307 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
H/R 22476 Fn3-51 26 rs2047271045 0.0656 None None N 0.107 0.046 0.0954503805726 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/R 22476 Fn3-51 26 rs2047271045 0.0656 None None N 0.107 0.046 0.0954503805726 gnomAD-4.0.0 6.57609E-06 None None None None I None 2.41371E-05 0 None 0 0 None 0 0 0 0 0
K/N 22669 Fn3-52 27 rs755897447 0.4248 0.447 0.942 N 0.514 0.212 0.176091768786 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/N 22669 Fn3-52 27 rs755897447 0.4248 0.447 0.942 N 0.514 0.212 0.176091768786 gnomAD-4.0.0 2.73776E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99659E-07 1.1595E-05 3.31499E-05
K/N 22768 Fn3-53 26 None 0.4287 None 0.002 N 0.303 0.076 0.107399877778 gnomAD-4.0.0 6.85087E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16371E-05 0
K/R 22768 Fn3-53 26 rs761210578 0.063 0.203 None N 0.161 0.112 0.0551355673512 gnomAD-2.1.1 7.19E-06 None None None None I None 8.3E-05 0 None 0 0 None 0 None 0 0 0
K/R 22768 Fn3-53 26 rs761210578 0.063 0.203 None N 0.161 0.112 0.0551355673512 gnomAD-3.1.2 3.29E-05 None None None None I None 1.20645E-04 0 0 0 0 None 0 0 0 0 0
K/R 22768 Fn3-53 26 rs761210578 0.063 0.203 None N 0.161 0.112 0.0551355673512 gnomAD-4.0.0 5.58341E-06 None None None None I None 1.06886E-04 0 None 0 0 None 0 0 8.48194E-07 0 0
L/S 23065 Fn3-55 26 rs768535148 0.1097 -0.124 0.166 N 0.306 0.11 0.493021045079 gnomAD-2.1.1 8.95E-05 None None None None I None 0 0 None 0 1.29306E-03 None 0 None 0 0 0
L/S 23065 Fn3-55 26 rs768535148 0.1097 -0.124 0.166 N 0.306 0.11 0.493021045079 gnomAD-3.1.2 4.61E-05 None None None None I None 0 0 0 0 1.3587E-03 None 0 0 0 0 0
L/S 23065 Fn3-55 26 rs768535148 0.1097 -0.124 0.166 N 0.306 0.11 0.493021045079 gnomAD-4.0.0 5.26964E-05 None None None None I None 0 0 None 0 1.83404E-03 None 0 0 0 1.09832E-05 3.20379E-05
V/A 23164 Fn3-56 26 None 0.0641 None None N 0.049 0.133 0.0666544352282 gnomAD-4.0.0 1.59184E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85936E-06 0 0
V/L 23164 Fn3-56 26 rs755341733 0.085 0.038 0.002 N 0.087 0.111 0.0716867268079 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
V/L 23164 Fn3-56 26 rs755341733 0.085 0.038 0.002 N 0.087 0.111 0.0716867268079 gnomAD-4.0.0 2.05292E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69871E-06 0 0
V/M 23164 Fn3-56 26 rs755341733 0.0821 -0.247 0.171 N 0.286 0.098 0.0920862733494 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/M 23164 Fn3-56 26 rs755341733 0.0821 -0.247 0.171 N 0.286 0.098 0.0920862733494 gnomAD-4.0.0 2.73723E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69871E-06 1.15955E-05 0
H/Y 23265 Fn3-57 26 rs1265649343 0.1097 0.929 0.521 N 0.397 0.26 0.197625483188 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
H/Y 23265 Fn3-57 26 rs1265649343 0.1097 0.929 0.521 N 0.397 0.26 0.197625483188 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/Y 23265 Fn3-57 26 rs1265649343 0.1097 0.929 0.521 N 0.397 0.26 0.197625483188 gnomAD-4.0.0 6.57626E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47076E-05 0 0
L/R 23460 Fn3-58 26 rs879027466 0.2601 None 0.995 N 0.584 0.489 0.547979623877 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
L/R 23460 Fn3-58 26 rs879027466 0.2601 None 0.995 N 0.584 0.489 0.547979623877 gnomAD-4.0.0 5.12638E-06 None None None None I None 6.76888E-05 0 None 0 0 None 0 0 0 0 0
K/N 23557 Fn3-59 26 None 0.4084 None 0.029 N 0.247 0.113 0.0401082797425 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/K 23752 Fn3-60 27 rs1709511196 0.0843 None 0.014 N 0.191 0.183 0.311387274539 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 23752 Fn3-60 27 rs1709511196 0.0843 None 0.014 N 0.191 0.183 0.311387274539 gnomAD-4.0.0 6.57678E-06 None None None None N None 0 6.55136E-05 None 0 0 None 0 0 0 0 0
L/P 23851 Fn3-61 26 None 0.144 None 0.927 N 0.387 0.263 0.655717221024 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 23949 Fn3-62 26 rs866868965 0.1053 0.55 0.958 N 0.641 0.387 0.290962096972 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/K 23949 Fn3-62 26 rs866868965 0.1053 0.55 0.958 N 0.641 0.387 0.290962096972 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 23949 Fn3-62 26 rs866868965 0.1053 0.55 0.958 N 0.641 0.387 0.290962096972 gnomAD-4.0.0 3.09957E-06 None None None None N None 4.00641E-05 0 None 0 0 None 0 0 8.47794E-07 0 1.60149E-05
D/G 24247 Fn3-64 26 rs1408225629 0.1345 None 0.822 N 0.429 0.202 0.297718772494 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/G 24247 Fn3-64 26 rs1408225629 0.1345 None 0.822 N 0.429 0.202 0.297718772494 gnomAD-4.0.0 2.89349E-06 None None None None I None 0 4.44622E-05 None 0 0 None 0 0 0 0 0
I/L 24348 Fn3-65 26 rs1708838358 0.1383 None 0.003 N 0.125 0.098 0.307016933798 gnomAD-4.0.0 1.36885E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79927E-06 0 0
I/S 24348 Fn3-65 26 rs1708837698 0.5353 None 0.884 N 0.435 0.383 0.633100741311 gnomAD-4.0.0 1.59241E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85994E-06 0 0
I/V 24348 Fn3-65 26 None 0.0755 None 0.001 N 0.121 0.062 0.342865806769 gnomAD-4.0.0 1.36885E-06 None None None None I None 2.99007E-05 0 None 0 0 None 0 0 8.99637E-07 0 0
L/F 24544 Fn3-66 26 rs777417650 0.1537 -0.579 0.984 N 0.554 0.336 0.509878532422 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.56E-05 0
L/F 24544 Fn3-66 26 rs777417650 0.1537 -0.579 0.984 N 0.554 0.336 0.509878532422 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
L/F 24544 Fn3-66 26 rs777417650 0.1537 -0.579 0.984 N 0.554 0.336 0.509878532422 gnomAD-4.0.0 2.29354E-05 None None None None I None 0 0 None 0 0 None 0 0 2.88238E-05 0 4.80492E-05
L/V 24544 Fn3-66 26 None 0.0762 None 0.011 N 0.264 0.15 0.277317399466 gnomAD-4.0.0 6.84397E-07 None None None None I None 2.98972E-05 0 None 0 0 None 0 0 0 0 0
E/K 24641 Fn3-67 26 rs993198870 0.4102 None 0.566 N 0.558 0.278 0.307648195649 gnomAD-4.0.0 3.42178E-06 None None None None N None 0 0 None 0 0 None 0 0 4.4979E-06 0 0
E/Q 24641 Fn3-67 26 None 0.2987 None 0.654 N 0.506 0.23 0.312608672186 gnomAD-4.0.0 6.84356E-06 None None None None N None 0 0 None 0 0 None 0 0 8.9958E-06 0 0
E/V 24641 Fn3-67 26 rs754060793 0.2827 0.22 0.755 N 0.523 0.361 None gnomAD-2.1.1 8.07E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 8.95E-06 0
E/V 24641 Fn3-67 26 rs754060793 0.2827 0.22 0.755 N 0.523 0.361 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/V 24641 Fn3-67 26 rs754060793 0.2827 0.22 0.755 N 0.523 0.361 None gnomAD-4.0.0 7.43779E-06 None None None None N None 2.67023E-05 0 None 0 0 None 0 0 8.47719E-06 0 0
K/R 24834 Fn3-68 27 None 0.0859 None 0.684 N 0.375 0.129 0.270889551736 gnomAD-4.0.0 8.40225E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
I/N 24933 Fn3-69 26 None 0.2298 None 0.001 N 0.337 0.135 0.602586112267 gnomAD-4.0.0 1.36866E-06 None None None None I None 2.99025E-05 0 None 0 0 None 0 0 8.99603E-07 0 0
I/T 24933 Fn3-69 26 rs769422476 0.205 -0.333 None N 0.175 0.114 0.454798141022 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 4.65E-05 1.78E-05 0
I/T 24933 Fn3-69 26 rs769422476 0.205 -0.333 None N 0.175 0.114 0.454798141022 gnomAD-4.0.0 2.73732E-06 None None None None I None 0 0 None 0 0 None 1.87294E-05 0 2.69881E-06 0 0
T/I 25031 Fn3-70 26 rs756363402 0.0735 0.126 None N 0.129 0.105 0.180583059064 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
A/T 25329 Fn3-72 26 None 0.0696 None 0.007 N 0.071 0.086 0.152612264143 gnomAD-4.0.0 1.59182E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
I/M 25430 Fn3-73 26 None 0.1696 None 0.864 N 0.568 0.186 0.326345978581 gnomAD-4.0.0 1.59184E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85917E-06 0 0
I/T 25430 Fn3-73 26 rs2154168088 0.5248 None 0.645 N 0.545 0.185 0.552781577438 gnomAD-4.0.0 4.8013E-06 None None None None I None 1.26695E-04 0 None 0 0 None 0 0 2.625E-06 0 0
I/V 25430 Fn3-73 26 rs756888687 0.0855 -0.032 0.002 N 0.235 0.053 0.373173300195 gnomAD-2.1.1 1.07E-05 None None None None I None 8.27E-05 2.83E-05 None 0 0 None 0 None 0 0 0
I/V 25430 Fn3-73 26 rs756888687 0.0855 -0.032 0.002 N 0.235 0.053 0.373173300195 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/V 25430 Fn3-73 26 rs756888687 0.0855 -0.032 0.002 N 0.235 0.053 0.373173300195 gnomAD-4.0.0 5.12638E-06 None None None None I None 5.07631E-05 1.69555E-05 None 0 0 None 0 0 0 0 0
L/F 25626 Fn3-74 26 None 0.1338 None 0.757 N 0.331 0.185 0.246773566709 gnomAD-4.0.0 6.88414E-07 None None None None I None 0 0 None 0 0 None 0 0 9.03347E-07 0 0
V/A 26113 Fn3-78 26 None 0.0727 None None N 0.039 0.056 0.0762999501168 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
L/I 26312 Fn3-79 27 None 0.0892 None 0.003 N 0.193 0.046 0.16115917748 gnomAD-4.0.0 1.59337E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86231E-06 0 0
L/P 26312 Fn3-79 27 None 0.2431 None 0.662 N 0.382 0.18 0.62999039529 gnomAD-4.0.0 2.73845E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59956E-06 0 0
D/E 26411 Fn3-80 26 None 0.0929 None 0.067 N 0.239 0.079 0.0762999501168 gnomAD-4.0.0 6.84293E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99552E-07 0 0
D/G 26411 Fn3-80 26 None 0.1482 None 0.958 N 0.656 0.421 0.305730143919 gnomAD-4.0.0 6.84292E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99544E-07 0 0
D/N 26411 Fn3-80 26 rs2154165912 0.1 None 0.988 N 0.7 0.261 0.26547132957 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 6.17284E-04 1.3125E-06 0 0
D/V 26411 Fn3-80 26 rs755457407 0.1105 0.447 0.994 N 0.739 0.477 0.502691689211 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/V 26411 Fn3-80 26 rs755457407 0.1105 0.447 0.994 N 0.739 0.477 0.502691689211 gnomAD-4.0.0 6.84292E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99544E-07 0 0
I/M 26708 Fn3-82 26 rs886043518 0.0746 -0.402 0.188 N 0.333 0.077 0.18274738541 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
I/M 26708 Fn3-82 26 rs886043518 0.0746 -0.402 0.188 N 0.333 0.077 0.18274738541 gnomAD-4.0.0 3.18369E-06 None None None None I None 0 0 None 0 2.77423E-05 None 0 2.41779E-04 0 0 0
E/A 26805 Fn3-83 26 rs370095455 0.1663 -0.033 0.064 N 0.411 0.223 None gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.71E-05 1.40568E-04
E/A 26805 Fn3-83 26 rs370095455 0.1663 -0.033 0.064 N 0.411 0.223 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/A 26805 Fn3-83 26 rs370095455 0.1663 -0.033 0.064 N 0.411 0.223 None gnomAD-4.0.0 4.58638E-05 None None None None N None 1.33558E-05 0 None 0 0 None 0 0 6.01883E-05 0 3.20349E-05
E/Q 26805 Fn3-83 26 None 0.1725 None 0.47 D 0.419 0.254 0.298056030225 gnomAD-4.0.0 6.00162E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56252E-06 0 0
A/T 26998 Fn3-84 27 rs373572123 0.0712 -0.306 0.012 N 0.221 0.044 None gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.57E-05 0
A/T 26998 Fn3-84 27 rs373572123 0.0712 -0.306 0.012 N 0.221 0.044 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/T 26998 Fn3-84 27 rs373572123 0.0712 -0.306 0.012 N 0.221 0.044 None gnomAD-4.0.0 4.9589E-06 None None None None I None 0 0 None 0 0 None 0 0 5.08663E-06 1.0988E-05 1.60164E-05
V/L 27097 Fn3-85 26 rs794729511 0.2889 0.103 0.704 N 0.28 0.094 0.192905019026 gnomAD-2.1.1 4.04E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
V/L 27097 Fn3-85 26 rs794729511 0.2889 0.103 0.704 N 0.28 0.094 0.192905019026 gnomAD-3.1.2 1.31E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 0 0 0
V/L 27097 Fn3-85 26 rs794729511 0.2889 0.103 0.704 N 0.28 0.094 0.192905019026 gnomAD-4.0.0 3.09925E-06 None None None None I None 5.33205E-05 0 None 0 0 None 0 0 0 0 1.60133E-05
V/M 27097 Fn3-85 26 rs794729511 0.2795 -0.199 0.988 N 0.311 0.235 0.264547087235 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.95E-06 0
V/M 27097 Fn3-85 26 rs794729511 0.2795 -0.199 0.988 N 0.311 0.235 0.264547087235 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 27097 Fn3-85 26 rs794729511 0.2795 -0.199 0.988 N 0.311 0.235 0.264547087235 gnomAD-4.0.0 9.29842E-06 None None None None I None 1.33518E-05 0 None 0 0 None 0 0 1.01727E-05 0 3.20379E-05
A/V 27195 Fn3-86 26 None 0.0798 None None N 0.187 0.116 0.176091768786 gnomAD-4.0.0 1.59254E-06 None None None None I None 0 0 None 0 2.78427E-05 None 0 0 0 0 0
L/V 27395 Fn3-87 27 rs1304635139 0.0793 None 0.166 N 0.305 0.04 0.137902524267 gnomAD-3.1.2 3.29E-05 None None None None I None 1.20726E-04 0 0 0 0 None 0 0 0 0 0
L/V 27395 Fn3-87 27 rs1304635139 0.0793 None 0.166 N 0.305 0.04 0.137902524267 gnomAD-4.0.0 6.09032E-06 None None None None I None 1.04891E-04 0 None 0 0 None 0 0 0 0 0
V/A 27494 Fn3-88 26 rs563168332 0.0702 -0.027 0.005 N 0.126 0.058 0.21737058555 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/A 27494 Fn3-88 26 rs563168332 0.0702 -0.027 0.005 N 0.126 0.058 0.21737058555 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 27494 Fn3-88 26 rs563168332 0.0702 -0.027 0.005 N 0.126 0.058 0.21737058555 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
V/A 27494 Fn3-88 26 rs563168332 0.0702 -0.027 0.005 N 0.126 0.058 0.21737058555 gnomAD-4.0.0 6.57022E-06 None None None None I None 2.40697E-05 0 None 0 0 None 0 0 0 0 0
L/F 27791 Fn3-90 26 rs755033702 0.1846 -0.488 0.995 N 0.519 0.243 0.518421792786 gnomAD-2.1.1 1.79E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 2.35E-05 0
L/F 27791 Fn3-90 26 rs755033702 0.1846 -0.488 0.995 N 0.519 0.243 0.518421792786 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 27791 Fn3-90 26 rs755033702 0.1846 -0.488 0.995 N 0.519 0.243 0.518421792786 gnomAD-4.0.0 5.57968E-06 None None None None I None 0 0 None 0 0 None 0 0 4.23907E-06 2.19679E-05 3.20482E-05
L/I 27791 Fn3-90 26 None 0.0835 None 0.57 N 0.503 0.162 0.384252928164 gnomAD-4.0.0 1.36905E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99698E-07 0 1.65804E-05
L/P 27791 Fn3-90 26 None 0.3694 None 0.998 N 0.661 0.522 0.629359936291 gnomAD-4.0.0 4.78062E-06 None None None None I None 0 0 None 0 0 None 0 7.24638E-04 0 0 0
E/A 28080 Fn3-92 26 None 0.0928 None 0.002 N 0.165 0.176 0.229264304666 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 28080 Fn3-92 26 rs1198142735 0.1001 None 0.784 N 0.358 0.174 0.264081493735 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 28080 Fn3-92 26 rs1198142735 0.1001 None 0.784 N 0.358 0.174 0.264081493735 gnomAD-4.0.0 2.5629E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78668E-06 0 0
V/I 28179 Fn3-93 26 None 0.0937 None 0.645 N 0.449 0.166 0.399889258716 gnomAD-4.0.0 1.36898E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99654E-07 0 1.65717E-05
E/D 28575 Fn3-96 26 rs752650483 0.0907 0.003 0.007 N 0.194 0.035 0.222439326576 gnomAD-2.1.1 7.15E-06 None None None None I None 4.13E-05 0 None 9.68E-05 0 None 0 None 0 0 0
E/D 28575 Fn3-96 26 rs752650483 0.0907 0.003 0.007 N 0.194 0.035 0.222439326576 gnomAD-4.0.0 1.59153E-06 None None None None I None 0 0 None 4.7669E-05 0 None 0 0 0 0 0
E/G 28575 Fn3-96 26 rs1703193280 0.1046 None 0.684 N 0.465 0.162 0.330331372229 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 28575 Fn3-96 26 rs1703193280 0.1046 None 0.684 N 0.465 0.162 0.330331372229 gnomAD-4.0.0 6.57376E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47024E-05 0 0
E/K 28575 Fn3-96 26 rs760762822 0.0842 0.773 0.037 N 0.193 0.132 0.232513804876 gnomAD-2.1.1 3.93E-05 None None None None I None 4.13E-05 0 None 0 0 None 0 None 0 7.83E-05 0
E/K 28575 Fn3-96 26 rs760762822 0.0842 0.773 0.037 N 0.193 0.132 0.232513804876 gnomAD-3.1.2 3.94E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 5.88E-05 0 0
E/K 28575 Fn3-96 26 rs760762822 0.0842 0.773 0.037 N 0.193 0.132 0.232513804876 gnomAD-4.0.0 5.70177E-05 None None None None I None 2.67073E-05 0 None 0 2.23105E-05 None 1.56353E-05 0 7.28943E-05 0 3.20256E-05
E/A 28870 Fn3-98 26 None 0.1441 None 0.939 N 0.571 0.347 0.434384183301 gnomAD-4.0.0 2.7369E-06 None None None None I None 0 0 None 0 0 None 0 0 3.598E-06 0 0
E/K 28967 Fn3-99 26 None 0.1598 None 0.812 N 0.586 0.297 0.314716216878 gnomAD-4.0.0 3.1828E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.8659E-05 0
V/A 29262 Fn3-101 26 rs1053653300 0.2913 0.033 0.704 N 0.25 0.105 0.353974658523 gnomAD-2.1.1 8.04E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 8.89E-06 0
V/A 29262 Fn3-101 26 rs1053653300 0.2913 0.033 0.704 N 0.25 0.105 0.353974658523 gnomAD-4.0.0 2.73669E-06 None None None None I None 0 2.23594E-05 None 0 5.04236E-05 None 0 0 8.99421E-07 0 0
V/G 29262 Fn3-101 26 rs1053653300 0.3644 -0.151 0.92 N 0.364 0.22 0.7110473393 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/G 29262 Fn3-101 26 rs1053653300 0.3644 -0.151 0.92 N 0.364 0.22 0.7110473393 gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
V/G 29262 Fn3-101 26 rs1053653300 0.3644 -0.151 0.92 N 0.364 0.22 0.7110473393 gnomAD-4.0.0 4.95732E-06 None None None None I None 8.00747E-05 0 None 0 0 None 0 0 0 1.09791E-05 1.60102E-05
V/L 29262 Fn3-101 26 rs1466272644 0.2744 0.054 0.906 N 0.366 0.103 0.278143212241 gnomAD-2.1.1 8.04E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
V/L 29262 Fn3-101 26 rs1466272644 0.2744 0.054 0.906 N 0.366 0.103 0.278143212241 gnomAD-3.1.2 4.6E-05 None None None None I None 0 4.58235E-04 0 0 0 None 0 0 0 0 0
V/L 29262 Fn3-101 26 rs1466272644 0.2744 0.054 0.906 N 0.366 0.103 0.278143212241 gnomAD-4.0.0 5.57685E-06 None None None None I None 0 1.5E-04 None 0 0 None 0 0 0 0 0
V/M 29262 Fn3-101 26 None 0.2425 None 0.996 D 0.337 0.19 0.347438807231 gnomAD-4.0.0 6.84174E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99421E-07 0 0
A/G 29360 Fn3-102 26 None 0.1507 None 0.625 N 0.347 0.217 0.197625483188 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 29559 Fn3-103 27 rs748038054 0.1429 0.062 0.484 N 0.331 0.136 0.166414681773 gnomAD-2.1.1 7.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
A/P 29559 Fn3-103 27 rs748038054 0.1429 0.062 0.484 N 0.331 0.136 0.166414681773 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/P 29559 Fn3-103 27 rs748038054 0.1429 0.062 0.484 N 0.331 0.136 0.166414681773 gnomAD-4.0.0 1.67303E-05 None None None None N None 0 0 None 0 0 None 0 0 2.20364E-05 0 1.60092E-05
A/T 29559 Fn3-103 27 rs748038054 0.0711 None None N 0.105 0.061 0.0846915920261 gnomAD-4.0.0 3.42081E-06 None None None None N None 0 0 None 0 0 None 0 0 4.4971E-06 0 0
I/T 29658 Fn3-104 26 rs750026544 0.0598 -0.169 None N 0.113 0.059 0.162503812791 gnomAD-2.1.1 2.42E-05 None None None None I None 0 2.9E-05 None 0 5.57E-05 None 9.81E-05 None 0 8.97E-06 0
I/T 29658 Fn3-104 26 rs750026544 0.0598 -0.169 None N 0.113 0.059 0.162503812791 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07039E-04 0
I/T 29658 Fn3-104 26 rs750026544 0.0598 -0.169 None N 0.113 0.059 0.162503812791 gnomAD-4.0.0 9.91508E-06 None None None None I None 1.33494E-05 1.66678E-05 None 0 2.22846E-05 None 0 0 5.93326E-06 6.58762E-05 0
I/V 29658 Fn3-104 26 rs200193877 0.0512 -0.048 None N 0.061 0.094 None gnomAD-2.1.1 1.64902E-04 None None None None I None 4.13E-05 5.66E-05 None 0 0 None 0 None 0 3.30896E-04 1.40924E-04
I/V 29658 Fn3-104 26 rs200193877 0.0512 -0.048 None N 0.061 0.094 None gnomAD-3.1.2 2.36531E-04 None None None None I None 2.41E-05 6.54E-05 0 0 0 None 0 0 4.9978E-04 0 0
I/V 29658 Fn3-104 26 rs200193877 0.0512 -0.048 None N 0.061 0.094 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
I/V 29658 Fn3-104 26 rs200193877 0.0512 -0.048 None N 0.061 0.094 None gnomAD-4.0.0 4.58525E-04 None None None None I None 6.66187E-05 4.99817E-05 None 0 2.22916E-05 None 0 0 5.68734E-04 1.09798E-05 9.44242E-04
V/I 29759 Fn3-105 26 None 0.0815 None 0.022 N 0.141 0.088 0.266843984389 gnomAD-4.0.0 1.59199E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8593E-06 0 0
L/F 29958 Fn3-106 26 rs1700014716 0.1779 None 0.987 N 0.466 0.325 0.535584383668 gnomAD-4.0.0 2.40101E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62542E-06 0 0
D/N 30055 Fn3-107 26 rs878879065 0.1543 None 0.993 N 0.663 0.327 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 30055 Fn3-107 26 rs878879065 0.1543 None 0.993 N 0.663 0.327 None gnomAD-4.0.0 6.57047E-06 None None None None I None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
D/V 30055 Fn3-107 26 rs759806991 0.2423 0.283 0.997 N 0.713 0.459 0.472344434578 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
D/V 30055 Fn3-107 26 rs759806991 0.2423 0.283 0.997 N 0.713 0.459 0.472344434578 gnomAD-4.0.0 4.78917E-06 None None None None I None 0 0 None 0 7.55896E-05 None 0 0 2.69829E-06 0 1.6564E-05
D/Y 30055 Fn3-107 26 None 0.3522 None 1.0 N 0.715 0.346 0.600342123009 gnomAD-4.0.0 1.59106E-06 None None None None I None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
E/A 30250 Fn3-108 27 rs776305858 0.1177 0.078 0.052 N 0.351 0.204 0.308278614506 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/A 30250 Fn3-108 27 rs776305858 0.1177 0.078 0.052 N 0.351 0.204 0.308278614506 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
E/A 30250 Fn3-108 27 rs776305858 0.1177 0.078 0.052 N 0.351 0.204 0.308278614506 gnomAD-4.0.0 2.56219E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.68075E-05 0
E/K 30250 Fn3-108 27 rs200651247 0.1403 0.716 0.001 N 0.129 0.202 None gnomAD-2.1.1 2.86E-05 None None None None N None 8.27E-05 8.49E-05 None 0 0 None 0 None 0 2.35E-05 0
E/K 30250 Fn3-108 27 rs200651247 0.1403 0.716 0.001 N 0.129 0.202 None gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 5.88E-05 0 0
E/K 30250 Fn3-108 27 rs200651247 0.1403 0.716 0.001 N 0.129 0.202 None gnomAD-4.0.0 1.12163E-04 None None None None N None 1.33476E-05 6.67022E-05 None 0 0 None 0 0 1.4409E-04 0 9.60584E-05
L/F 30645 Fn3-111 27 rs1237954818 0.109 -0.554 0.171 N 0.245 0.25 0.33085137897 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
L/F 30645 Fn3-111 27 rs1237954818 0.109 -0.554 0.171 N 0.245 0.25 0.33085137897 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
L/F 30645 Fn3-111 27 rs1237954818 0.109 -0.554 0.171 N 0.245 0.25 0.33085137897 gnomAD-4.0.0 1.86164E-06 None None None None I None 2.67158E-05 0 None 0 0 None 0 0 8.48875E-07 0 0
L/I 30645 Fn3-111 27 None 0.0709 None 0.055 N 0.254 0.1 0.21279746466 gnomAD-4.0.0 3.42626E-06 None None None None I None 0 0 None 0 0 None 0 0 4.50459E-06 0 0
L/P 30645 Fn3-111 27 rs886038985 0.135 -0.024 0.106 N 0.356 0.211 0.596177834036 gnomAD-2.1.1 8.05E-06 None None None None I None 0 5.81E-05 None 0 0 None 0 None 0 0 0
L/P 30645 Fn3-111 27 rs886038985 0.135 -0.024 0.106 N 0.356 0.211 0.596177834036 gnomAD-4.0.0 4.7899E-06 None None None None I None 0 6.86593E-05 None 0 0 None 0 0 0 0 0
V/A 30846 Fn3-113 26 rs77968867 0.1381 -0.289 0.003 N 0.153 0.216 None gnomAD-2.1.1 8.10008E-04 None None None None I None 8.97287E-03 1.98053E-04 None 0 0 None 0 None 0 2.34E-05 0
V/A 30846 Fn3-113 26 rs77968867 0.1381 -0.289 0.003 N 0.153 0.216 None gnomAD-3.1.2 2.45952E-03 None None None None I None 8.766E-03 2.62123E-04 0 0 0 None 0 3.16456E-03 2.94E-05 0 1.91571E-03
V/A 30846 Fn3-113 26 rs77968867 0.1381 -0.289 0.003 N 0.153 0.216 None 1000 genomes 2.79553E-03 None None None None I None 9.1E-03 2.9E-03 None None 0 0 None None None 0 None
V/A 30846 Fn3-113 26 rs77968867 0.1381 -0.289 0.003 N 0.153 0.216 None gnomAD-4.0.0 4.58552E-04 None None None None I None 9.17309E-03 2.66702E-04 None 0 0 None 0 1.65017E-04 5.93315E-06 0 4.48158E-04
L/F 31041 Fn3-114 26 None 0.1344 None 0.055 N 0.277 0.153 0.28492961333 gnomAD-4.0.0 6.84176E-07 None None None None I None 0 0 None 0 2.51915E-05 None 0 0 0 0 0
L/I 31041 Fn3-114 26 rs1698098552 0.0683 None None N 0.086 0.079 0.180583059064 gnomAD-4.0.0 6.84176E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99442E-07 0 0
L/V 31041 Fn3-114 26 None 0.0715 None None N 0.105 0.08 0.20549828249 gnomAD-4.0.0 6.84176E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99442E-07 0 0
K/T 31334 Fn3-116 27 None 0.0898 None None N 0.141 0.127 0.261217442401 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/E 31531 Fn3-118 26 rs1039995106 0.1547 -0.387 None N 0.105 0.16 0.210429274316 gnomAD-2.1.1 8.13E-06 None None None None I None 0 5.82E-05 None 0 0 None 0 None 0 0 0
A/E 31531 Fn3-118 26 rs1039995106 0.1547 -0.387 None N 0.105 0.16 0.210429274316 gnomAD-3.1.2 1.31E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
A/E 31531 Fn3-118 26 rs1039995106 0.1547 -0.387 None N 0.105 0.16 0.210429274316 gnomAD-4.0.0 1.30583E-05 None None None None I None 0 6.68114E-05 None 0 0 None 0 0 1.44617E-05 0 0
A/T 31531 Fn3-118 26 rs765066425 0.0712 -0.175 0.007 N 0.154 0.057 0.17948927462 gnomAD-2.1.1 3.97E-05 None None None None I None 0 0 None 0 5.66426E-04 None 0 None 0 0 0
A/T 31531 Fn3-118 26 rs765066425 0.0712 -0.175 0.007 N 0.154 0.057 0.17948927462 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 7.71903E-04 None 0 0 0 0 0
A/T 31531 Fn3-118 26 rs765066425 0.0712 -0.175 0.007 N 0.154 0.057 0.17948927462 gnomAD-4.0.0 8.70684E-06 None None None None I None 0 0 None 0 2.46217E-04 None 0 0 2.55251E-06 0 0
A/V 31531 Fn3-118 26 rs1039995106 0.0615 0.018 None N 0.045 0.13 0.252681307341 gnomAD-2.1.1 3.18E-05 None None None None I None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
A/V 31531 Fn3-118 26 rs1039995106 0.0615 0.018 None N 0.045 0.13 0.252681307341 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/V 31531 Fn3-118 26 rs1039995106 0.0615 0.018 None N 0.045 0.13 0.252681307341 gnomAD-4.0.0 1.86547E-06 None None None None I None 0 1.67029E-05 None 0 0 None 0 0 1.70137E-06 0 0
E/A 31832 Fn3-120 26 None 0.1083 None 0.645 N 0.526 0.346 0.31291088546 gnomAD-4.0.0 1.36847E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79903E-06 0 0
E/K 31832 Fn3-120 26 rs753982218 0.1235 0.764 0.645 N 0.559 0.279 0.32082282376 gnomAD-2.1.1 8.03E-06 None None None None I None 0 5.79E-05 None 0 0 None 0 None 0 0 0
E/K 31832 Fn3-120 26 rs753982218 0.1235 0.764 0.645 N 0.559 0.279 0.32082282376 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 31832 Fn3-120 26 rs753982218 0.1235 0.764 0.645 N 0.559 0.279 0.32082282376 gnomAD-4.0.0 6.40579E-06 None None None None I None 0 8.47371E-05 None 0 0 None 0 0 0 0 0
E/V 31832 Fn3-120 26 None 0.1303 None 0.928 N 0.568 0.47 0.476908202251 gnomAD-4.0.0 6.84233E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99517E-06 0 0
M/I 31934 Fn3-121 26 rs1365026291 0.2936 0.441 0.012 N 0.379 0.115 0.241664281697 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
M/I 31934 Fn3-121 26 rs1365026291 0.2936 0.441 0.012 N 0.379 0.115 0.241664281697 gnomAD-4.0.0 6.36576E-06 None None None None I None 0 0 None 0 0 None 0 0 1.14359E-05 0 0
M/T 31934 Fn3-121 26 None 0.1758 None None N 0.174 0.112 0.3349148499 gnomAD-4.0.0 7.52664E-06 None None None None I None 0 2.23614E-05 None 0 0 None 0 0 8.09581E-06 0 1.65651E-05
M/V 31934 Fn3-121 26 rs1696075318 0.074 None 0.005 N 0.213 0.086 0.292787519742 gnomAD-4.0.0 1.59144E-06 None None None None I None 0 0 None 4.76735E-05 0 None 0 0 0 0 0
T/K 32130 Fn3-122 26 None 0.1415 -0.16 0.579 N 0.323 0.145 0.227260227426 gnomAD-2.1.1 4.11E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/K 32130 Fn3-122 26 None 0.1415 -0.16 0.579 N 0.323 0.145 0.227260227426 gnomAD-4.0.0 1.37385E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79922E-06 0 0
T/M 32130 Fn3-122 26 rs368998895 0.0693 -0.024 0.216 N 0.275 0.11 None gnomAD-2.1.1 1.82E-05 None None None None I None 1.24699E-04 0 None 0 5.16E-05 None 0 None 0 7.85E-06 0
T/M 32130 Fn3-122 26 rs368998895 0.0693 -0.024 0.216 N 0.275 0.11 None gnomAD-3.1.2 4.6E-05 None None None None I None 1.44809E-04 0 0 0 0 None 0 0 1.47E-05 0 0
T/M 32130 Fn3-122 26 rs368998895 0.0693 -0.024 0.216 N 0.275 0.11 None gnomAD-4.0.0 7.46315E-06 None None None None I None 1.06812E-04 0 None 0 2.23125E-05 None 0 0 2.5432E-06 0 0
T/R 32130 Fn3-122 26 rs368998895 0.1404 0.017 0.736 N 0.341 0.146 0.293502639404 gnomAD-2.1.1 4.11E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/R 32130 Fn3-122 26 rs368998895 0.1404 0.017 0.736 N 0.341 0.146 0.293502639404 gnomAD-4.0.0 1.37385E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79922E-06 0 0
E/D 32425 Fn3-124 27 None 0.138 None 0.722 N 0.531 0.092 0.351614576976 gnomAD-4.0.0 1.59297E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
E/K 32425 Fn3-124 27 rs1169300714 0.1048 0.654 0.565 N 0.579 0.176 0.298056030225 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/K 32425 Fn3-124 27 rs1169300714 0.1048 0.654 0.565 N 0.579 0.176 0.298056030225 gnomAD-4.0.0 1.59306E-06 None None None None N None 5.65803E-05 0 None 0 0 None 0 0 0 0 0
E/K 32524 Fn3-125 26 None 0.0801 None 0.939 N 0.547 0.299 0.392395365052 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86041E-06 0 0
E/G 32625 Fn3-126 26 None 0.1539 None 1.0 N 0.636 0.449 0.394536629495 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
E/K 33023 Fn3-129 26 rs757929496 0.2804 0.868 0.999 N 0.727 0.378 0.352262096564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
E/K 33023 Fn3-129 26 rs757929496 0.2804 0.868 0.999 N 0.727 0.378 0.352262096564 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85863E-06 0 0
A/T 33316 Fn3-130 27 rs374295768 0.0777 -0.239 0.004 N 0.094 0.042 None gnomAD-2.1.1 2.50374E-04 None None None None I None 4.14E-05 1.13417E-04 None 2.8079E-03 5.14E-05 None 9.49077E-04 None 0 3.13E-05 2.82087E-04
A/T 33316 Fn3-130 27 rs374295768 0.0777 -0.239 0.004 N 0.094 0.042 None gnomAD-3.1.2 1.44604E-04 None None None None I None 4.83E-05 0 0 2.59217E-03 0 None 0 0 5.88E-05 1.45168E-03 0
A/T 33316 Fn3-130 27 rs374295768 0.0777 -0.239 0.004 N 0.094 0.042 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
A/T 33316 Fn3-130 27 rs374295768 0.0777 -0.239 0.004 N 0.094 0.042 None gnomAD-4.0.0 1.3634E-04 None None None None I None 3.99925E-05 6.66889E-05 None 2.3314E-03 2.22946E-05 None 0 0 3.30589E-05 1.03238E-03 1.60092E-04
A/V 33316 Fn3-130 27 rs1406589986 0.0924 -0.051 0.001 N 0.097 0.042 0.180583059064 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
A/S 33417 Fn3-131 26 None 0.0864 None None N 0.087 0.03 0.136095386433 gnomAD-4.0.0 1.72826E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.686E-05 0
A/V 33417 Fn3-131 26 None 0.0696 None 0.062 N 0.377 0.125 0.149567049428 gnomAD-4.0.0 7.07895E-07 None None None None I None 0 0 None 0 0 None 0 0 9.19065E-07 0 0
A/T 33714 Fn3-132 26 rs776948324 0.0861 -0.148 0.999 N 0.682 0.216 0.337135696972 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/T 33714 Fn3-132 26 rs776948324 0.0861 -0.148 0.999 N 0.682 0.216 0.337135696972 gnomAD-4.0.0 1.23157E-05 None None None None N None 0 0 None 0 0 None 0 0 1.43912E-05 1.15931E-05 1.65645E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.