Structural position:

  • Domain Type: Fn3
  • Aligned Position: 29
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/I 15683 Fn3-1 27 rs2057733530 0.162 None 0.627 N 0.363 0.13 0.279776271856 gnomAD-4.0.0 1.59398E-06 None None None None I None 0 0 None 0 2.78878E-05 None 0 0 0 0 0
Y/F 15784 Fn3-2 27 None 0.1148 None 0.006 N 0.201 0.189 0.323342291347 gnomAD-4.0.0 1.5937E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86272E-06 0 0
K/E 15885 Fn3-3 27 None 0.2097 None 0.012 N 0.121 0.129 0.173771789658 gnomAD-4.0.0 1.63879E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.09023E-05
D/G 16081 Fn3-4 27 None 0.3938 None 0.27 D 0.353 0.28 0.276898752692 gnomAD-4.0.0 1.59394E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86352E-06 0 0
D/N 16081 Fn3-4 27 None 0.1054 None 0.002 N 0.059 0.1 0.184867976434 gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25002E-06 0 0
D/H 16377 Fn3-6 27 rs757542062 0.9627 0.011 1.0 D 0.593 0.434 0.41883969893 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
D/H 16377 Fn3-6 27 rs757542062 0.9627 0.011 1.0 D 0.593 0.434 0.41883969893 gnomAD-4.0.0 6.84613E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99803E-07 0 0
D/N 16377 Fn3-6 27 rs757542062 0.6388 0.493 1.0 N 0.625 0.385 0.36893422563 gnomAD-2.1.1 1.79E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 3.15E-05 0
D/N 16377 Fn3-6 27 rs757542062 0.6388 0.493 1.0 N 0.625 0.385 0.36893422563 gnomAD-3.1.2 3.29E-05 None None None None I None 7.25E-05 0 0 0 0 None 0 0 1.47E-05 2.07383E-04 0
D/N 16377 Fn3-6 27 rs757542062 0.6388 0.493 1.0 N 0.625 0.385 0.36893422563 gnomAD-4.0.0 1.79846E-05 None None None None I None 8.02289E-05 0 None 0 0 None 0 1.6469E-04 1.52638E-05 4.39309E-05 0
D/E 16476 Fn3-7 27 None 0.1534 None 0.02 N 0.179 0.032 0.134241683229 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 16476 Fn3-7 27 None 0.1224 None 0.939 N 0.478 0.299 0.281381271821 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
H/Q 16577 Fn3-8 27 rs2115558 0.7617 0.03 1.0 N 0.627 0.34 0.0954503805726 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/Q 16577 Fn3-8 27 rs2115558 0.7617 0.03 1.0 N 0.627 0.34 0.0954503805726 gnomAD-3.1.2 6.59E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
H/Q 16577 Fn3-8 27 rs2115558 0.7617 0.03 1.0 N 0.627 0.34 0.0954503805726 gnomAD-4.0.0 1.24036E-06 None None None None N None 0 3.33923E-05 None 0 0 None 0 0 0 0 0
H/R 16577 Fn3-8 27 rs752077667 0.5218 -0.574 1.0 N 0.591 0.409 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
H/R 16577 Fn3-8 27 rs752077667 0.5218 -0.574 1.0 N 0.591 0.409 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/R 16577 Fn3-8 27 rs752077667 0.5218 -0.574 1.0 N 0.591 0.409 None gnomAD-4.0.0 8.97936E-06 None None None None N None 0 0 None 0 0 None 0 0 1.67721E-05 0 0
K/E 16878 Fn3-11 27 None 0.3036 None 0.989 N 0.436 0.269 0.345632371893 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Y/C 17173 Fn3-13 27 rs748656984 0.3268 0.308 0.997 N 0.655 0.297 0.451599300725 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
Y/C 17173 Fn3-13 27 rs748656984 0.3268 0.308 0.997 N 0.655 0.297 0.451599300725 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/C 17173 Fn3-13 27 rs748656984 0.3268 0.308 0.997 N 0.655 0.297 0.451599300725 gnomAD-4.0.0 7.69422E-06 None None None None I None 0 0 None 0 0 None 0 0 2.39582E-06 6.70367E-05 0
Y/H 17173 Fn3-13 27 None 0.2909 None 0.99 N 0.547 0.302 0.315314060047 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 17395 Fn3-14 27 rs1479797110 0.6968 None 1.0 N 0.402 0.214 0.342400092842 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
D/E 17395 Fn3-14 27 rs1479797110 0.6968 None 1.0 N 0.402 0.214 0.342400092842 gnomAD-4.0.0 4.10842E-06 None None None None I None 8.98257E-05 0 None 0 0 None 0 0 0 0 4.97463E-05
F/V 17595 Fn3-16 27 rs868539342 0.1988 None 0.081 N 0.316 0.125 0.288727942641 gnomAD-4.0.0 1.59314E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86128E-06 0 0
D/G 17790 Fn3-17 27 None 0.8825 None 1.0 N 0.682 0.533 0.429435026966 gnomAD-4.0.0 2.05361E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69935E-06 0 0
S/N 17888 Fn3-18 27 rs778009539 0.1151 -0.161 None N 0.069 0.074 0.0611884634855 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/N 17888 Fn3-18 27 rs778009539 0.1151 -0.161 None N 0.069 0.074 0.0611884634855 gnomAD-4.0.0 1.61001E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43802E-05 0
S/R 17888 Fn3-18 27 None 0.8637 None 0.317 N 0.395 0.164 0.18274738541 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 18091 Fn3-19 27 rs2054393920 0.6831 None 1.0 N 0.369 0.161 0.235038932564 gnomAD-4.0.0 1.11577E-05 None None None None I None 0 0 None 0 1.94921E-04 None 0 0 0 0 0
D/H 18091 Fn3-19 27 rs751597873 0.8996 -0.302 1.0 N 0.585 0.399 0.285698343383 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/N 18091 Fn3-19 27 None 0.4655 None 1.0 N 0.605 0.398 0.267299060538 gnomAD-4.0.0 1.59423E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86362E-06 0 0
D/N 18505 Fn3-22 27 rs563090275 0.1271 0.515 0.029 N 0.057 0.079 0.247322355667 gnomAD-2.1.1 1.79E-05 None None None None I None 4.14E-05 5.66E-05 None 0 5.15E-05 None 0 None 0 7.84E-06 0
D/N 18505 Fn3-22 27 rs563090275 0.1271 0.515 0.029 N 0.057 0.079 0.247322355667 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/N 18505 Fn3-22 27 rs563090275 0.1271 0.515 0.029 N 0.057 0.079 0.247322355667 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
D/N 18505 Fn3-22 27 rs563090275 0.1271 0.515 0.029 N 0.057 0.079 0.247322355667 gnomAD-4.0.0 6.19969E-06 None None None None I None 2.66745E-05 5.0035E-05 None 3.38135E-05 4.46808E-05 None 0 0 1.69593E-06 0 0
N/T 18605 Fn3-23 27 None 0.53 None 0.999 N 0.499 0.37 0.369682402691 gnomAD-4.0.0 1.61138E-06 None None None None I None 0 0 None 0 0 None 0 0 2.892E-06 0 0
D/G 18811 Fn3-24 28 None 0.8308 None 0.998 N 0.674 0.537 0.409665357357 gnomAD-4.0.0 1.61786E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.49107E-05 0
D/N 18811 Fn3-24 28 rs2052663852 0.4488 None 0.999 D 0.697 0.395 0.439445477881 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 18811 Fn3-24 28 rs2052663852 0.4488 None 0.999 D 0.697 0.395 0.439445477881 gnomAD-4.0.0 3.12002E-06 None None None None I None 0 0 None 0 0 None 0 0 4.25075E-06 0 0
Y/H 18910 Fn3-25 27 None 0.1529 None 0.1 N 0.281 0.07 0.173771789658 gnomAD-4.0.0 1.59601E-06 None None None None I None 0 0 None 0 0 None 0 2.41896E-04 0 0 0
Y/N 18910 Fn3-25 27 None 0.0898 None 0.982 N 0.625 0.269 0.365509141856 gnomAD-4.0.0 1.59601E-06 None None None None I None 0 0 None 0 2.79298E-05 None 0 0 0 0 0
D/E 19506 Fn3-29 28 rs1238125586 0.5357 -0.021 1.0 N 0.403 0.334 0.351830644314 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
D/E 19506 Fn3-29 28 rs1238125586 0.5357 -0.021 1.0 N 0.403 0.334 0.351830644314 gnomAD-4.0.0 2.87473E-05 None None None None I None 0 0 None 0 0 None 0 0 3.7783E-05 0 0
D/G 19506 Fn3-29 28 None 0.7332 None 1.0 N 0.72 0.542 0.411265580357 gnomAD-4.0.0 1.20037E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31255E-06 0 0
H/R 19604 Fn3-30 26 rs754807338 0.0753 0.294 None N 0.076 0.096 0.144782658237 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 9.94E-05 0 None 0 None 0 1.77E-05 0
H/R 19604 Fn3-30 26 rs754807338 0.0753 0.294 None N 0.076 0.096 0.144782658237 gnomAD-4.0.0 1.43301E-05 None None None None N None 0 0 None 4.77008E-05 0 None 0 0 1.42985E-05 4.2991E-05 0
H/Y 19604 Fn3-30 26 rs780811337 0.0772 1.113 None N 0.063 0.129 0.104622674875 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
H/Y 19604 Fn3-30 26 rs780811337 0.0772 1.113 None N 0.063 0.129 0.104622674875 gnomAD-4.0.0 1.59225E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85971E-06 0 0
H/D 19706 Fn3-31 27 None 0.3527 None None N 0.099 0.244 0.183819452728 gnomAD-4.0.0 1.20036E-06 None None None None I None 6.33633E-05 0 None 0 0 None 0 0 0 0 0
H/L 19706 Fn3-31 27 None 0.2271 None 0.117 N 0.47 0.182 0.238096912614 gnomAD-4.0.0 1.20035E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
D/E 19903 Fn3-32 27 rs2154185463 0.2782 None 1.0 N 0.403 0.283 0.364926071151 gnomAD-4.0.0 1.59464E-06 None None None None I None 0 2.29337E-05 None 0 0 None 0 0 0 0 0
D/H 19903 Fn3-32 27 rs374163882 0.374 -0.003 1.0 N 0.591 0.453 None gnomAD-2.1.1 2.17E-05 None None None None I None 2.49917E-04 0 None 0 0 None 0 None 0 0 0
D/H 19903 Fn3-32 27 rs374163882 0.374 -0.003 1.0 N 0.591 0.453 None gnomAD-3.1.2 5.26E-05 None None None None I None 1.93022E-04 0 0 0 0 None 0 0 0 0 0
D/H 19903 Fn3-32 27 rs374163882 0.374 -0.003 1.0 N 0.591 0.453 None gnomAD-4.0.0 8.06444E-06 None None None None I None 1.73602E-04 0 None 0 0 None 0 0 0 0 0
D/N 19903 Fn3-32 27 rs374163882 0.1259 None 1.0 N 0.623 0.383 0.343788945184 gnomAD-4.0.0 3.42472E-06 None None None None I None 0 0 None 0 0 None 0 0 2.7001E-06 0 3.31763E-05
D/V 19903 Fn3-32 27 None 0.2999 None 1.0 N 0.706 0.593 0.605567239383 gnomAD-4.0.0 2.73975E-06 None None None None I None 0 0 None 0 0 None 0 0 3.60013E-06 0 0
R/C 20003 Fn3-33 27 rs1039014549 0.4893 -0.049 1.0 N 0.749 0.453 0.403896168776 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/C 20003 Fn3-33 27 rs1039014549 0.4893 -0.049 1.0 N 0.749 0.453 0.403896168776 gnomAD-3.1.2 2.63E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 20003 Fn3-33 27 rs1039014549 0.4893 -0.049 1.0 N 0.749 0.453 0.403896168776 gnomAD-4.0.0 9.91863E-06 None None None None I None 8.01282E-05 0 None 0 0 None 0 0 5.93432E-06 3.29468E-05 0
R/G 20003 Fn3-33 27 rs1039014549 0.6497 -0.337 1.0 N 0.575 0.421 0.358134431457 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/G 20003 Fn3-33 27 rs1039014549 0.6497 -0.337 1.0 N 0.575 0.421 0.358134431457 gnomAD-4.0.0 1.36882E-06 None None None None I None 0 2.23864E-05 None 0 0 None 0 0 8.99607E-07 0 0
R/H 20003 Fn3-33 27 rs756091180 0.2171 -0.685 1.0 N 0.737 0.393 0.376216005999 gnomAD-2.1.1 1.79E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 4E-05 1.57E-05 0
R/H 20003 Fn3-33 27 rs756091180 0.2171 -0.685 1.0 N 0.737 0.393 0.376216005999 gnomAD-3.1.2 3.29E-05 None None None None I None 2.41E-05 0 0 0 0 None 2.82486E-04 0 1.47E-05 0 0
R/H 20003 Fn3-33 27 rs756091180 0.2171 -0.685 1.0 N 0.737 0.393 0.376216005999 gnomAD-4.0.0 2.41762E-05 None None None None I None 4.00598E-05 0 None 0 0 None 1.09361E-04 0 2.11941E-05 3.2946E-05 1.60174E-05
R/P 20003 Fn3-33 27 None 0.9744 None 1.0 N 0.686 0.391 0.401185642668 gnomAD-4.0.0 6.84407E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99612E-07 0 0
D/N 20198 Fn3-34 28 None 0.3167 None 0.999 N 0.687 0.376 0.489728331402 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
S/G 20397 Fn3-36 27 None 0.1269 None 0.425 N 0.271 0.154 0.141422826196 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/S 20694 Fn3-38 27 None 0.5512 None 1.0 N 0.645 0.347 0.545346552841 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/H 20989 Fn3-40 27 rs1338725751 0.1648 0.295 0.994 N 0.461 0.19 0.269111216191 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
Y/H 20989 Fn3-40 27 rs1338725751 0.1648 0.295 0.994 N 0.461 0.19 0.269111216191 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 0 None 0 2.78149E-05 None 0 0 0 0 0
Y/C 21090 Fn3-41 27 rs377480514 0.4999 -0.04 1.0 N 0.658 0.41 0.347217280506 gnomAD-2.1.1 8.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
Y/C 21090 Fn3-41 27 rs377480514 0.4999 -0.04 1.0 N 0.658 0.41 0.347217280506 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 9.41E-05 0 0 0 0
Y/C 21090 Fn3-41 27 rs377480514 0.4999 -0.04 1.0 N 0.658 0.41 0.347217280506 gnomAD-4.0.0 1.30314E-05 None None None None I None 0 0 None 0 0 None 1.56299E-05 0 1.5277E-05 0 3.20688E-05
Y/F 21090 Fn3-41 27 rs377480514 0.2033 -0.561 0.999 N 0.45 0.204 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
Y/F 21090 Fn3-41 27 rs377480514 0.2033 -0.561 0.999 N 0.45 0.204 None gnomAD-4.0.0 1.43894E-05 None None None None I None 0 0 None 0 0 None 0 0 1.89147E-05 0 0
N/D 21292 Fn3-42 27 None 0.1988 None 0.999 N 0.556 0.338 0.27855597813 gnomAD-4.0.0 6.92895E-07 None None None None N None 0 0 None 0 2.62743E-05 None 0 0 0 0 0
N/H 21292 Fn3-42 27 None 0.21 None 1.0 N 0.657 0.362 0.315609569513 gnomAD-4.0.0 2.77219E-06 None None None None N None 0 0 None 0 0 None 0 0 2.72713E-06 1.16225E-05 0
N/Y 21292 Fn3-42 27 None 0.2071 None 1.0 N 0.678 0.423 0.460526725402 gnomAD-4.0.0 6.92895E-07 None None None None N None 0 0 None 0 0 None 0 0 9.08833E-07 0 0
R/C 21392 Fn3-43 27 rs72646859 0.7518 -0.102 1.0 N 0.745 0.302 None gnomAD-2.1.1 6.1088E-04 None None None None I None 1.65399E-04 1.98154E-04 None 0 1.70068E-03 None 6.54E-05 None 0 9.69219E-04 1.40449E-04
R/C 21392 Fn3-43 27 rs72646859 0.7518 -0.102 1.0 N 0.745 0.302 None gnomAD-3.1.2 5.39296E-04 None None None None I None 1.44802E-04 4.58776E-04 0 0 9.70874E-04 None 0 3.16456E-03 9.26634E-04 0 0
R/C 21392 Fn3-43 27 rs72646859 0.7518 -0.102 1.0 N 0.745 0.302 None gnomAD-4.0.0 8.00317E-04 None None None None I None 1.20029E-04 2.66764E-04 None 0 1.20643E-03 None 0 3.30688E-04 9.72561E-04 6.59036E-05 9.12876E-04
R/G 21392 Fn3-43 27 None 0.8854 None 1.0 N 0.536 0.266 0.455996456696 gnomAD-4.0.0 6.84489E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65755E-05
R/H 21392 Fn3-43 27 None 0.3694 -0.873 1.0 N 0.739 0.362 None gnomAD-2.1.1 6.43E-05 None None None None I None 4.14E-05 1.98154E-04 None 0 0 None 0 None 4E-05 7.03E-05 0
R/H 21392 Fn3-43 27 None 0.3694 -0.873 1.0 N 0.739 0.362 None gnomAD-3.1.2 6.58E-05 None None None None I None 4.83E-05 1.31027E-04 0 0 0 None 0 0 8.83E-05 0 0
R/H 21392 Fn3-43 27 None 0.3694 -0.873 1.0 N 0.739 0.362 None gnomAD-4.0.0 5.1457E-05 None None None None I None 5.34331E-05 1.66767E-04 None 3.38066E-05 0 None 6.24902E-05 0 4.91795E-05 2.1965E-05 6.40841E-05
R/L 21392 Fn3-43 27 rs777176324 0.8467 0.27 1.0 N 0.536 0.407 0.499985177359 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 4.64E-05 0 0
R/L 21392 Fn3-43 27 rs777176324 0.8467 0.27 1.0 N 0.536 0.407 0.499985177359 gnomAD-4.0.0 1.36899E-06 None None None None I None 0 0 None 0 0 None 1.87273E-05 0 8.99789E-07 0 0
R/P 21392 Fn3-43 27 rs777176324 0.9874 None 1.0 N 0.667 0.378 0.388653054685 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/P 21392 Fn3-43 27 rs777176324 0.9874 None 1.0 N 0.667 0.378 0.388653054685 gnomAD-4.0.0 6.57626E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47102E-05 0 0
E/A 21586 Fn3-44 28 rs2048580704 0.4411 None 0.999 N 0.6 0.456 0.345859378078 gnomAD-4.0.0 3.1844E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85987E-06 0 3.0259E-05
S/G 21685 Fn3-45 27 rs1335760990 0.1186 -0.389 0.961 N 0.417 0.162 0.234412748748 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/G 21685 Fn3-45 27 rs1335760990 0.1186 -0.389 0.961 N 0.417 0.162 0.234412748748 gnomAD-4.0.0 3.18492E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86632E-05 0
H/R 21783 Fn3-46 27 rs1223104137 0.2786 None 0.97 N 0.433 0.413 0.276065633971 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/R 21783 Fn3-46 27 rs1223104137 0.2786 None 0.97 N 0.433 0.413 0.276065633971 gnomAD-4.0.0 3.86359E-06 None None None None N None 1.69371E-05 0 None 0 0 None 0 0 4.80811E-06 0 0
D/H 22081 Fn3-48 27 None 0.3023 None 0.427 N 0.362 0.109 0.237489013734 gnomAD-4.0.0 1.36929E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7993E-06 0 0
D/N 22081 Fn3-48 27 None 0.098 None None N 0.052 0.105 0.18995819373 gnomAD-4.0.0 6.84646E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99651E-07 0 0
Y/C 22182 Fn3-49 27 rs879016147 0.3982 None 0.998 N 0.667 0.257 0.351614576976 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
Y/C 22182 Fn3-49 27 rs879016147 0.3982 None 0.998 N 0.667 0.257 0.351614576976 gnomAD-4.0.0 9.3169E-06 None None None None I None 0 0 None 0 0 None 0 0 1.2733E-05 0 0
Y/D 22182 Fn3-49 27 rs878854327 0.6873 1.182 0.991 N 0.67 0.455 0.409124616982 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
Y/D 22182 Fn3-49 27 rs878854327 0.6873 1.182 0.991 N 0.67 0.455 0.409124616982 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
Y/D 22182 Fn3-49 27 rs878854327 0.6873 1.182 0.991 N 0.67 0.455 0.409124616982 gnomAD-4.0.0 6.43525E-06 None None None None I None 8.46539E-05 0 None 0 0 None 0 0 0 0 0
I/M 22380 Fn3-50 27 None 0.1355 None 0.317 N 0.333 0.105 0.385906861911 gnomAD-4.0.0 6.84406E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99667E-07 0 0
I/N 22380 Fn3-50 27 rs773461641 0.3187 -0.146 0.188 N 0.479 0.323 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/N 22380 Fn3-50 27 rs773461641 0.3187 -0.146 0.188 N 0.479 0.323 None gnomAD-4.0.0 1.36883E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79935E-06 0 0
I/T 22380 Fn3-50 27 rs773461641 0.1875 -0.557 0.062 N 0.34 0.214 0.468003879618 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 8.92E-06 0
I/T 22380 Fn3-50 27 rs773461641 0.1875 -0.557 0.062 N 0.34 0.214 0.468003879618 gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 2.06954E-04 0
I/T 22380 Fn3-50 27 rs773461641 0.1875 -0.557 0.062 N 0.34 0.214 0.468003879618 gnomAD-4.0.0 1.85964E-05 None None None None I None 4.00652E-05 0 None 0 0 None 0 0 1.94997E-05 2.19626E-05 3.20349E-05
D/G 22670 Fn3-52 28 rs377188703 0.5685 -0.085 0.698 N 0.535 0.39 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/G 22670 Fn3-52 28 rs377188703 0.5685 -0.085 0.698 N 0.535 0.39 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 22670 Fn3-52 28 rs377188703 0.5685 -0.085 0.698 N 0.535 0.39 None gnomAD-4.0.0 6.57687E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47128E-05 0 0
Y/F 22867 Fn3-54 27 rs1397080164 0.1667 0.014 0.981 N 0.531 0.247 0.411401001288 gnomAD-2.1.1 4.07E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
Y/F 22867 Fn3-54 27 rs1397080164 0.1667 0.014 0.981 N 0.531 0.247 0.411401001288 gnomAD-4.0.0 1.59732E-06 None None None None I None 5.67988E-05 0 None 0 0 None 0 0 0 0 0
Y/H 22867 Fn3-54 27 rs368484355 0.4317 0.556 0.983 N 0.595 0.372 None gnomAD-2.1.1 1.08E-05 None None None None I None 4.14E-05 0 None 0 0 None 0 None 0 1.58E-05 0
Y/H 22867 Fn3-54 27 rs368484355 0.4317 0.556 0.983 N 0.595 0.372 None gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 4.41E-05 0 0
Y/H 22867 Fn3-54 27 rs368484355 0.4317 0.556 0.983 N 0.595 0.372 None gnomAD-4.0.0 1.86229E-05 None None None None I None 2.67337E-05 0 None 0 0 None 0 0 2.37623E-05 0 0
D/E 23165 Fn3-56 27 rs757041441 0.1594 -0.145 0.704 N 0.297 0.124 0.349870743963 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
D/E 23165 Fn3-56 27 rs757041441 0.1594 -0.145 0.704 N 0.297 0.124 0.349870743963 gnomAD-4.0.0 1.59178E-06 None None None None N None 0 0 None 0 2.77577E-05 None 0 0 0 0 0
D/H 23165 Fn3-56 27 rs778699055 0.1997 -0.287 0.988 N 0.31 0.179 0.32306181527 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/H 23165 Fn3-56 27 rs778699055 0.1997 -0.287 0.988 N 0.31 0.179 0.32306181527 gnomAD-4.0.0 3.42153E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49785E-06 0 0
D/N 23165 Fn3-56 27 None 0.0987 None 0.134 N 0.168 0.11 0.215869574891 gnomAD-4.0.0 6.84306E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9957E-07 0 0
Y/S 23266 Fn3-57 27 None 0.6016 None 0.967 N 0.582 0.486 0.344945010812 gnomAD-4.0.0 1.71684E-06 None None None None I None 0 0 None 0 0 None 0 0 3.01448E-06 0 0
I/M 23461 Fn3-58 27 None 0.106 None 0.484 N 0.348 0.111 0.3571064206 gnomAD-4.0.0 1.59186E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8595E-06 0 0
I/R 23461 Fn3-58 27 rs775762472 0.4974 0.241 0.484 N 0.453 0.326 0.53787198782 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65673E-04
I/R 23461 Fn3-58 27 rs775762472 0.4974 0.241 0.484 N 0.453 0.326 0.53787198782 gnomAD-4.0.0 1.59189E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
I/V 23461 Fn3-58 27 rs1170300318 0.0986 -0.205 None N 0.107 0.037 0.257292322809 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/V 23461 Fn3-58 27 rs1170300318 0.0986 -0.205 None N 0.107 0.037 0.257292322809 gnomAD-4.0.0 3.18369E-06 None None None None I None 0 4.57352E-05 None 0 0 None 0 0 0 0 0
H/D 23558 Fn3-59 27 None 0.4823 None 0.936 N 0.407 0.456 0.286848849266 gnomAD-4.0.0 2.05285E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69868E-06 0 0
H/Q 23558 Fn3-59 27 rs761993177 0.4493 0.344 0.962 N 0.397 0.349 0.18274738541 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/Q 23558 Fn3-59 27 rs761993177 0.4493 0.344 0.962 N 0.397 0.349 0.18274738541 gnomAD-4.0.0 6.84298E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
H/R 23558 Fn3-59 27 rs765191581 0.3603 -0.033 0.009 N 0.285 0.203 0.181679512989 gnomAD-2.1.1 1.61E-05 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 2.67E-05 0
H/R 23558 Fn3-59 27 rs765191581 0.3603 -0.033 0.009 N 0.285 0.203 0.181679512989 gnomAD-3.1.2 3.29E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 1.47E-05 0 0
H/R 23558 Fn3-59 27 rs765191581 0.3603 -0.033 0.009 N 0.285 0.203 0.181679512989 gnomAD-4.0.0 8.05712E-06 None None None None I None 6.67468E-05 0 None 0 0 None 0 0 4.23855E-06 0 4.80415E-05
H/Y 23558 Fn3-59 27 None 0.131 None 0.96 N 0.427 0.374 0.26547132957 gnomAD-4.0.0 6.84285E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9956E-07 0 0
S/C 23852 Fn3-61 27 rs1177699712 0.1145 -0.278 0.928 N 0.366 0.3 0.350964488264 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/C 23852 Fn3-61 27 rs1177699712 0.1145 -0.278 0.928 N 0.366 0.3 0.350964488264 gnomAD-4.0.0 1.64235E-05 None None None None I None 0 0 None 0 0 None 0 0 2.15901E-05 0 0
D/H 24149 Fn3-63 28 None 0.3618 None 0.005 N 0.161 0.127 0.225902525712 gnomAD-4.0.0 1.8644E-06 None None None None I None 0 0 None 0 0 None 0 2.69833E-04 0 0 0
Y/C 24349 Fn3-65 27 None 0.6067 None 0.997 N 0.684 0.468 0.404870348458 gnomAD-4.0.0 1.36884E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79928E-06 0 0
Y/N 24349 Fn3-65 27 rs1559421745 0.7557 None 0.942 N 0.527 0.316 0.412328234245 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
Y/N 24349 Fn3-65 27 rs1559421745 0.7557 None 0.942 N 0.527 0.316 0.412328234245 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 3.66327E-05
L/P 24545 Fn3-66 27 rs865922152 0.7705 None 0.323 N 0.393 0.252 0.37262878642 gnomAD-4.0.0 1.36879E-06 None None None None I None 2.99079E-05 0 None 0 0 None 0 0 0 0 1.657E-05
L/R 24545 Fn3-66 27 None 0.3977 None 0.159 N 0.389 0.168 0.33085137897 gnomAD-4.0.0 1.36879E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79924E-06 0 0
H/R 24642 Fn3-67 27 None 0.5986 None 0.951 N 0.446 0.242 0.269111216191 gnomAD-4.0.0 4.77602E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71863E-06 1.43295E-05 0
Y/C 24835 Fn3-68 28 rs201724962 0.5052 0.326 0.999 N 0.652 0.542 None gnomAD-2.1.1 6.87E-05 None None None None N None 0 2.9E-05 None 1.19808E-03 0 None 0 None 0 1.79E-05 3.33E-04
Y/C 24835 Fn3-68 28 rs201724962 0.5052 0.326 0.999 N 0.652 0.542 None gnomAD-3.1.2 5.92E-05 None None None None N None 0 1.31079E-04 0 1.1534E-03 0 None 0 0 1.47E-05 0 9.5511E-04
Y/C 24835 Fn3-68 28 rs201724962 0.5052 0.326 0.999 N 0.652 0.542 None gnomAD-4.0.0 3.84324E-05 None None None None N None 0 6.67156E-05 None 1.18275E-03 0 None 0 0 9.32537E-06 0 1.92197E-04
S/G 24934 Fn3-69 27 rs1231946544 0.1096 -0.479 0.174 N 0.359 0.153 0.137902524267 gnomAD-4.0.0 2.05299E-06 None None None None I None 0 0 None 0 0 None 0 0 1.7992E-06 0 1.65717E-05
S/N 24934 Fn3-69 27 rs1450413002 0.0814 None None N 0.083 0.059 0.0551355673512 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 24934 Fn3-69 27 rs1450413002 0.0814 None None N 0.083 0.059 0.0551355673512 gnomAD-4.0.0 2.56329E-06 None None None None I None 0 0 None 0 0 None 0 0 2.39412E-06 1.34012E-05 0
S/R 24934 Fn3-69 27 rs1345094321 0.6255 -0.087 0.782 N 0.394 0.16 0.163833314356 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/R 24934 Fn3-69 27 rs1345094321 0.6255 -0.087 0.782 N 0.394 0.16 0.163833314356 gnomAD-4.0.0 1.5919E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
Y/C 25032 Fn3-70 27 None 0.2455 None 0.997 N 0.691 0.252 0.28492961333 gnomAD-4.0.0 2.73904E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70065E-06 0 1.65804E-05
Y/S 25032 Fn3-70 27 None 0.273 None 0.125 N 0.394 0.216 0.260735089382 gnomAD-4.0.0 6.84761E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00218E-07 0 0
Q/H 25231 Fn3-71 28 None 0.2338 None 0.151 N 0.227 0.081 0.163833314356 gnomAD-4.0.0 1.59256E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85963E-06 0 0
S/A 25330 Fn3-72 27 None 0.0797 None 0.052 N 0.422 0.101 0.152612264143 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/C 25431 Fn3-73 27 rs79906856 0.4711 0.324 1.0 N 0.675 0.518 None gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 2.23289E-04 None 0 None 0 0 0
Y/C 25431 Fn3-73 27 rs79906856 0.4711 0.324 1.0 N 0.675 0.518 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.56E-05 0 0 3.86847E-04 None 0 0 0 0 0
Y/C 25431 Fn3-73 27 rs79906856 0.4711 0.324 1.0 N 0.675 0.518 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
Y/C 25431 Fn3-73 27 rs79906856 0.4711 0.324 1.0 N 0.675 0.518 None gnomAD-4.0.0 1.61139E-05 None None None None I None 0 1.66728E-05 None 0 5.35499E-04 None 0 0 8.47719E-07 0 0
Y/H 25431 Fn3-73 27 None 0.6158 None 1.0 N 0.661 0.434 0.275215494804 gnomAD-4.0.0 8.21181E-06 None None None None I None 0 0 None 0 0 None 0 0 1.07947E-05 0 0
Y/N 25431 Fn3-73 27 rs1488563673 0.6772 0.157 1.0 N 0.667 0.516 0.471211772063 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
Y/N 25431 Fn3-73 27 rs1488563673 0.6772 0.157 1.0 N 0.667 0.516 0.471211772063 gnomAD-4.0.0 6.84317E-07 None None None None I None 2.98936E-05 0 None 0 0 None 0 0 0 0 0
H/N 25724 Fn3-75 27 None 0.1772 None 0.997 N 0.461 0.356 0.262662153117 gnomAD-4.0.0 1.59204E-06 None None None None N None 5.6638E-05 0 None 0 0 None 0 0 0 0 0
H/R 25724 Fn3-75 27 None 0.3395 -0.049 0.999 N 0.563 0.377 0.28058544554 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/R 25724 Fn3-75 27 None 0.3395 -0.049 0.999 N 0.563 0.377 0.28058544554 gnomAD-4.0.0 1.592E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43324E-05 0
Y/H 25917 Fn3-76 28 rs370137092 0.2257 0.57 0.994 N 0.577 0.317 None gnomAD-2.1.1 3.63E-05 None None None None I None 0 5.82E-05 None 0 0 None 0 None 0 6.23E-05 0
Y/H 25917 Fn3-76 28 rs370137092 0.2257 0.57 0.994 N 0.577 0.317 None gnomAD-3.1.2 6.57E-05 None None None None I None 0 1.9667E-04 0 0 0 None 0 0 1.02941E-04 0 0
Y/H 25917 Fn3-76 28 rs370137092 0.2257 0.57 0.994 N 0.577 0.317 None gnomAD-4.0.0 5.14524E-05 None None None None I None 0 8.34585E-05 None 0 0 None 0 0 6.27354E-05 2.19602E-05 3.20431E-05
N/T 26016 Fn3-77 27 None 0.1014 None 0.349 N 0.368 0.092 0.240491677333 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
Y/C 26114 Fn3-78 27 None 0.3369 None 1.0 N 0.687 0.465 0.372087925617 gnomAD-4.0.0 1.59195E-06 None None None None I None 0 0 None 0 2.77439E-05 None 0 0 0 0 0
S/G 26412 Fn3-80 27 None 0.11 None 0.101 N 0.265 0.086 0.162503812791 gnomAD-4.0.0 1.36859E-06 None None None None I None 0 0 None 0 0 None 0 3.46741E-04 0 0 0
S/N 26412 Fn3-80 27 rs752040235 0.1067 0.076 0.002 N 0.139 0.048 0.141422826196 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 4.64E-05 0 0
S/N 26412 Fn3-80 27 rs752040235 0.1067 0.076 0.002 N 0.139 0.048 0.141422826196 gnomAD-4.0.0 3.42143E-06 None None None None I None 0 0 None 0 0 None 1.87322E-05 0 3.59817E-06 0 0
Y/C 26513 Fn3-81 27 rs1575685631 0.4325 None 1.0 N 0.679 0.505 0.372993862945 gnomAD-4.0.0 4.793E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29672E-06 0 0
I/T 26709 Fn3-82 27 rs757763969 0.1114 -0.424 0.684 N 0.415 0.13 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/T 26709 Fn3-82 27 rs757763969 0.1114 -0.424 0.684 N 0.415 0.13 None gnomAD-4.0.0 1.5055E-05 None None None None I None 0 0 None 0 0 None 0 0 1.97912E-05 0 0
H/R 26806 Fn3-83 27 rs181766682 0.3156 -0.045 0.004 N 0.223 0.139 None gnomAD-2.1.1 5.36E-05 None None None None N None 6.2004E-04 0 None 0 0 None 0 None 0 0 0
H/R 26806 Fn3-83 27 rs181766682 0.3156 -0.045 0.004 N 0.223 0.139 None gnomAD-3.1.2 1.57768E-04 None None None None N None 5.54912E-04 6.56E-05 0 0 0 None 0 0 0 0 0
H/R 26806 Fn3-83 27 rs181766682 0.3156 -0.045 0.004 N 0.223 0.139 None 1000 genomes 7.98722E-04 None None None None N None 3E-03 0 None None 0 0 None None None 0 None
H/R 26806 Fn3-83 27 rs181766682 0.3156 -0.045 0.004 N 0.223 0.139 None gnomAD-4.0.0 3.78027E-05 None None None None N None 7.46468E-04 3.33389E-05 None 0 0 None 0 0 8.47711E-07 1.09791E-05 1.60113E-05
Y/C 26999 Fn3-84 28 rs1252117916 0.3036 None 0.999 N 0.656 0.543 0.602722737475 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/C 26999 Fn3-84 28 rs1252117916 0.3036 None 0.999 N 0.656 0.543 0.602722737475 gnomAD-4.0.0 4.33876E-06 None None None None I None 0 0 None 0 0 None 0 0 5.93414E-06 0 0
Y/S 27196 Fn3-86 27 rs1704959686 0.3687 None 0.994 N 0.636 0.377 0.435590266561 gnomAD-3.1.2 1.31E-05 None None None None I None 0 1.30976E-04 0 0 0 None 0 0 0 0 0
Y/S 27196 Fn3-86 27 rs1704959686 0.3687 None 0.994 N 0.636 0.377 0.435590266561 gnomAD-4.0.0 1.31437E-05 None None None None I None 0 1.30976E-04 None 0 0 None 0 0 0 0 0
Q/E 27396 Fn3-87 28 rs371604558 0.0738 0.287 0.285 N 0.363 0.316 None gnomAD-2.1.1 2.82E-05 None None None None I None 6.46E-05 1.16003E-04 None 0 0 None 0 None 0 1.78E-05 0
Q/E 27396 Fn3-87 28 rs371604558 0.0738 0.287 0.285 N 0.363 0.316 None gnomAD-3.1.2 7.23E-05 None None None None I None 4.83E-05 3.93443E-04 0 0 0 None 0 0 4.41E-05 0 0
Q/E 27396 Fn3-87 28 rs371604558 0.0738 0.287 0.285 N 0.363 0.316 None gnomAD-4.0.0 2.1072E-05 None None None None I None 2.67101E-05 1.66761E-04 None 0 0 None 0 0 1.69533E-05 0 3.20225E-05
Q/L 27396 Fn3-87 28 rs367804525 0.1517 0.318 0.326 N 0.438 0.201 None gnomAD-2.1.1 2.82E-05 None None None None I None 6.46E-05 1.15982E-04 None 0 0 None 0 None 0 1.78E-05 0
Q/L 27396 Fn3-87 28 rs367804525 0.1517 0.318 0.326 N 0.438 0.201 None gnomAD-3.1.2 7.23E-05 None None None None I None 4.83E-05 3.93185E-04 0 0 0 None 0 0 4.41E-05 0 0
Q/L 27396 Fn3-87 28 rs367804525 0.1517 0.318 0.326 N 0.438 0.201 None gnomAD-4.0.0 2.10706E-05 None None None None I None 2.6698E-05 1.66728E-04 None 0 0 None 0 0 1.69531E-05 0 3.20225E-05
Q/R 27396 Fn3-87 28 rs367804525 0.1479 0.436 0.491 N 0.367 0.167 0.202949470691 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/R 27396 Fn3-87 28 rs367804525 0.1479 0.436 0.491 N 0.367 0.167 0.202949470691 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/R 27396 Fn3-87 28 rs367804525 0.1479 0.436 0.491 N 0.367 0.167 0.202949470691 gnomAD-4.0.0 1.23945E-06 None None None None I None 0 0 None 0 0 None 0 0 8.47653E-07 1.09784E-05 0
Y/C 27596 Fn3-89 27 None 0.563 None 0.999 N 0.615 0.343 0.432604763906 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 27792 Fn3-90 27 rs747559346 0.201 -0.361 0.822 N 0.456 0.305 0.517709844387 gnomAD-2.1.1 1.61E-05 None None None None I None 0 2.91E-05 None 0 0 None 6.55E-05 None 0 8.9E-06 0
I/T 27792 Fn3-90 27 rs747559346 0.201 -0.361 0.822 N 0.456 0.305 0.517709844387 gnomAD-4.0.0 7.5308E-06 None None None None I None 0 2.24024E-05 None 0 0 None 0 0 6.29845E-06 2.32094E-05 1.65848E-05
S/N 27889 Fn3-91 27 rs1459332648 0.0923 None None N 0.079 0.067 0.143124449307 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 27889 Fn3-91 27 rs1459332648 0.0923 None None N 0.079 0.067 0.143124449307 gnomAD-4.0.0 2.5637E-06 None None None None N None 0 0 None 0 0 None 0 0 4.7878E-06 0 0
S/R 27889 Fn3-91 27 rs779485837 0.6145 -0.216 None N 0.202 0.147 0.171388866994 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.12108E-04 None 0 None 0 0 0
Y/S 28081 Fn3-92 27 None 0.458 None 0.967 N 0.465 0.43 0.454798141022 gnomAD-4.0.0 1.59178E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85865E-06 0 0
Y/D 28278 Fn3-94 27 rs1336515508 0.4271 1.122 0.942 N 0.649 0.359 0.472344434578 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
Y/D 28278 Fn3-94 27 rs1336515508 0.4271 1.122 0.942 N 0.649 0.359 0.472344434578 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/D 28278 Fn3-94 27 rs1336515508 0.4271 1.122 0.942 N 0.649 0.359 0.472344434578 gnomAD-4.0.0 2.56221E-06 None None None None I None 0 0 None 0 0 None 0 0 4.7857E-06 0 0
S/R 28576 Fn3-96 27 rs1313703882 0.4645 None 0.497 N 0.528 0.112 0.218112801441 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/S 28677 Fn3-97 27 rs1553561985 0.9101 None 0.983 N 0.585 0.396 0.61589852972 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
H/P 28968 Fn3-99 27 rs754679595 0.8421 None 0.998 N 0.583 0.465 0.372993862945 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/P 28968 Fn3-99 27 rs754679595 0.8421 None 0.998 N 0.583 0.465 0.372993862945 gnomAD-4.0.0 1.23938E-06 None None None None I None 2.66873E-05 0 None 0 0 None 0 0 0 0 0
H/R 28968 Fn3-99 27 rs754679595 0.2782 0.075 0.967 N 0.451 0.287 0.340273420219 gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.35E-05 0
H/R 28968 Fn3-99 27 rs754679595 0.2782 0.075 0.967 N 0.451 0.287 0.340273420219 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
H/R 28968 Fn3-99 27 rs754679595 0.2782 0.075 0.967 N 0.451 0.287 0.340273420219 gnomAD-4.0.0 8.67563E-06 None None None None I None 1.33437E-05 0 None 0 0 None 0 0 1.10187E-05 0 0
Y/C 29164 Fn3-100 28 rs1318040081 0.2622 0.24 1.0 N 0.658 0.535 0.471456661759 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Y/C 29164 Fn3-100 28 rs1318040081 0.2622 0.24 1.0 N 0.658 0.535 0.471456661759 gnomAD-4.0.0 1.59111E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
S/P 29263 Fn3-101 27 None 0.8189 None 0.984 N 0.536 0.229 0.229264304666 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
F/L 29361 Fn3-102 27 rs746746013 0.945 None 0.625 N 0.374 0.184 0.0297737177859 gnomAD-4.0.0 6.84284E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
D/A 29560 Fn3-103 28 None 0.3943 None 0.999 N 0.559 0.419 0.381916209588 gnomAD-4.0.0 1.36832E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79884E-06 0 0
A/V 29659 Fn3-104 27 None 0.0699 None None N 0.091 0.088 0.0716867268079 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
I/L 29959 Fn3-106 27 None 0.1148 None 0.126 N 0.242 0.081 0.336155897331 gnomAD-4.0.0 1.20046E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31265E-06 0 0
I/T 29959 Fn3-106 27 rs374906767 0.1715 -0.558 0.822 N 0.435 0.251 None gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 5.6E-05 None 0 None 0 0 0
I/T 29959 Fn3-106 27 rs374906767 0.1715 -0.558 0.822 N 0.435 0.251 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
I/T 29959 Fn3-106 27 rs374906767 0.1715 -0.558 0.822 N 0.435 0.251 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
I/T 29959 Fn3-106 27 rs374906767 0.1715 -0.558 0.822 N 0.435 0.251 None gnomAD-4.0.0 4.96346E-06 None None None None I None 0 0 None 0 2.23204E-05 None 0 0 4.23816E-06 2.19611E-05 0
D/G 30251 Fn3-108 28 rs374014652 0.5349 -0.566 0.996 N 0.557 0.483 None gnomAD-2.1.1 8.05E-06 None None None None N None 1.29199E-04 0 None 0 0 None 0 None 0 0 0
D/G 30251 Fn3-108 28 rs374014652 0.5349 -0.566 0.996 N 0.557 0.483 None gnomAD-4.0.0 3.18245E-06 None None None None N None 1.13122E-04 0 None 0 0 None 0 0 0 0 0
D/H 30251 Fn3-108 28 rs768172616 0.7254 -0.529 1.0 N 0.655 0.358 0.328222422547 gnomAD-4.0.0 1.59124E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85814E-06 0 0
D/N 30251 Fn3-108 28 rs768172616 0.2378 None 0.999 N 0.633 0.404 0.299427821978 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
D/N 30251 Fn3-108 28 rs768172616 0.2378 None 0.999 N 0.633 0.404 0.299427821978 gnomAD-4.0.0 6.57134E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07039E-04 0
R/C 30448 Fn3-110 27 rs756030714 0.3984 -0.26 0.992 N 0.708 0.308 None gnomAD-2.1.1 3.93E-05 None None None None I None 4.13E-05 0 None 0 0 None 0 None 0 7.82E-05 0
R/C 30448 Fn3-110 27 rs756030714 0.3984 -0.26 0.992 N 0.708 0.308 None gnomAD-3.1.2 3.29E-05 None None None None I None 7.25E-05 0 0 0 0 None 9.44E-05 0 1.47E-05 0 0
R/C 30448 Fn3-110 27 rs756030714 0.3984 -0.26 0.992 N 0.708 0.308 None gnomAD-4.0.0 2.9752E-05 None None None None I None 6.68163E-05 0 None 0 0 None 3.12774E-05 0 3.30607E-05 1.09791E-05 1.60133E-05
R/H 30448 Fn3-110 27 rs374474227 0.1782 -1.102 0.011 N 0.271 0.119 None gnomAD-2.1.1 7.14E-05 None None None None I None 0 2.83E-05 None 0 0 None 2.94195E-04 None 0 7.82E-05 0
R/H 30448 Fn3-110 27 rs374474227 0.1782 -1.102 0.011 N 0.271 0.119 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 2.07211E-04 0
R/H 30448 Fn3-110 27 rs374474227 0.1782 -1.102 0.011 N 0.271 0.119 None gnomAD-4.0.0 6.8799E-05 None None None None I None 1.33593E-05 3.33511E-05 None 3.37952E-05 0 None 0 1.64582E-04 6.44252E-05 2.85476E-04 6.40492E-05
R/L 30448 Fn3-110 27 None 0.5814 None 0.417 N 0.577 0.174 0.396794106654 gnomAD-4.0.0 6.84316E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9957E-07 0 0
N/H 30646 Fn3-111 28 rs786205328 0.1467 None 1.0 N 0.679 0.465 0.215869574891 gnomAD-4.0.0 1.37025E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80153E-06 0 0
N/I 30646 Fn3-111 28 None 0.4188 None 1.0 N 0.739 0.531 0.559502987721 gnomAD-4.0.0 1.37013E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80133E-06 0 0
N/S 30646 Fn3-111 28 rs72648245 0.1056 0.048 0.999 N 0.535 0.402 None gnomAD-2.1.1 7.21857E-04 None None None None I None 6.20142E-03 9.34685E-04 None 0 5.13E-05 None 2.29268E-04 None 0 6.25E-05 4.22178E-04
N/S 30646 Fn3-111 28 rs72648245 0.1056 0.048 0.999 N 0.535 0.402 None gnomAD-3.1.2 1.84E-03 None None None None I None 6.05607E-03 1.50642E-03 0 0 0 None 0 0 5.88E-05 0 9.57854E-04
N/S 30646 Fn3-111 28 rs72648245 0.1056 0.048 0.999 N 0.535 0.402 None 1000 genomes 1.19808E-03 None None None None I None 2.3E-03 2.9E-03 None None 0 1E-03 None None None 0 None
N/S 30646 Fn3-111 28 rs72648245 0.1056 0.048 0.999 N 0.535 0.402 None gnomAD-4.0.0 4.11908E-04 None None None None I None 6.16E-03 1.16698E-03 None 0 2.23125E-05 None 1.5625E-05 1.65399E-04 7.044E-05 1.53866E-04 5.13034E-04
F/S 30847 Fn3-113 27 rs906140300 0.3242 None 0.942 N 0.602 0.368 0.473065174198 gnomAD-4.0.0 2.05255E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6983E-06 0 0
L/P 31042 Fn3-114 27 rs1575474263 0.6352 None 0.995 N 0.595 0.422 0.754779769779 gnomAD-4.0.0 1.36835E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79888E-06 0 0
D/A 31335 Fn3-116 28 None 0.6718 None 1.0 N 0.727 0.482 0.487843537783 gnomAD-4.0.0 1.36835E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31863E-05 0
D/E 31335 Fn3-116 28 rs779852538 0.4435 -0.103 1.0 N 0.391 0.239 0.422040124859 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/E 31335 Fn3-116 28 rs779852538 0.4435 -0.103 1.0 N 0.391 0.239 0.422040124859 gnomAD-4.0.0 6.84172E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99436E-07 0 0
D/G 31335 Fn3-116 28 None 0.5947 None 1.0 N 0.681 0.527 0.418718287753 gnomAD-4.0.0 6.84173E-07 None None None None I None 2.98757E-05 0 None 0 0 None 0 0 0 0 0
D/H 31335 Fn3-116 28 None 0.7987 None 1.0 N 0.637 0.43 0.437527004654 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Y 31434 Fn3-117 27 rs773946401 0.1573 0.985 0.985 N 0.303 0.309 0.228597637076 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 0
H/Y 31434 Fn3-117 27 rs773946401 0.1573 0.985 0.985 N 0.303 0.309 0.228597637076 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
H/Y 31434 Fn3-117 27 rs773946401 0.1573 0.985 0.985 N 0.303 0.309 0.228597637076 gnomAD-4.0.0 7.68675E-06 None None None None I None 0 0 None 0 0 None 0 0 0 8.04096E-05 0
S/T 31833 Fn3-120 27 rs764271138 0.0761 0.071 0.22 N 0.39 0.129 0.181679512989 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.55E-05 0
S/T 31833 Fn3-120 27 rs764271138 0.0761 0.071 0.22 N 0.39 0.129 0.181679512989 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 31833 Fn3-120 27 rs764271138 0.0761 0.071 0.22 N 0.39 0.129 0.181679512989 gnomAD-4.0.0 5.57753E-06 None None None None I None 0 0 None 0 0 None 0 0 6.7812E-06 0 1.60118E-05
I/T 32131 Fn3-122 27 rs978818932 0.1183 None None N 0.231 0.114 0.492267288202 gnomAD-4.0.0 2.74698E-06 None None None None I None 2.98846E-05 0 None 0 0 None 0 0 2.69877E-06 0 0
I/V 32131 Fn3-122 27 rs567606606 0.0623 -0.094 0.002 N 0.096 0.073 0.343334270461 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
I/V 32131 Fn3-122 27 rs567606606 0.0623 -0.094 0.002 N 0.096 0.073 0.343334270461 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
I/V 32131 Fn3-122 27 rs567606606 0.0623 -0.094 0.002 N 0.096 0.073 0.343334270461 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
I/V 32131 Fn3-122 27 rs567606606 0.0623 -0.094 0.002 N 0.096 0.073 0.343334270461 gnomAD-4.0.0 2.57988E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.68147E-05 0
Y/D 32228 Fn3-123 27 None 0.34 None 0.801 N 0.391 0.279 0.535774538982 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/H 32228 Fn3-123 27 None 0.0833 None 0.002 N 0.078 0.126 0.207176502487 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/N 32228 Fn3-123 27 rs1277957429 0.1436 -0.017 0.801 N 0.415 0.237 0.448597761117 gnomAD-2.1.1 3.19E-05 None None None None I None 1.1489E-04 0 None 0 0 None 0 None 0 0 0
Y/N 32228 Fn3-123 27 rs1277957429 0.1436 -0.017 0.801 N 0.415 0.237 0.448597761117 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Y/N 32228 Fn3-123 27 rs1277957429 0.1436 -0.017 0.801 N 0.415 0.237 0.448597761117 gnomAD-4.0.0 6.57601E-06 None None None None I None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
D/E 32525 Fn3-125 27 rs1473354201 0.1123 -0.113 0.002 N 0.169 0.057 0.139678290688 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/E 32525 Fn3-125 27 rs1473354201 0.1123 -0.113 0.002 N 0.169 0.057 0.139678290688 gnomAD-4.0.0 1.36883E-06 None None None None I None 0 0 None 0 0 None 0 0 1.7993E-06 0 0
D/V 32525 Fn3-125 27 rs750281394 0.1598 0.326 0.781 N 0.716 0.35 0.599912457102 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
D/V 32525 Fn3-125 27 rs750281394 0.1598 0.326 0.781 N 0.716 0.35 0.599912457102 gnomAD-4.0.0 3.18474E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86862E-05 0
D/N 32626 Fn3-126 27 None 0.0924 None 0.003 N 0.197 0.201 0.185906805712 gnomAD-4.0.0 6.00165E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56256E-06 0 0
D/Y 32626 Fn3-126 27 None 0.1217 None 0.957 N 0.604 0.494 0.489174143269 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
D/A 32822 Fn3-127 28 rs191054704 0.5267 0.131 1.0 N 0.689 0.463 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
D/A 32822 Fn3-127 28 rs191054704 0.5267 0.131 1.0 N 0.689 0.463 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
D/A 32822 Fn3-127 28 rs191054704 0.5267 0.131 1.0 N 0.689 0.463 None gnomAD-4.0.0 6.56711E-06 None None None None N None 0 0 None 0 1.9305E-04 None 0 0 0 0 0
D/G 32822 Fn3-127 28 rs191054704 0.5965 -0.106 1.0 N 0.646 0.513 0.32580497728 gnomAD-2.1.1 5.72E-05 None None None None N None 0 2.83E-05 None 0 7.68285E-04 None 0 None 0 0 0
D/G 32822 Fn3-127 28 rs191054704 0.5965 -0.106 1.0 N 0.646 0.513 0.32580497728 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.77812E-04 None 0 0 0 0 0
D/G 32822 Fn3-127 28 rs191054704 0.5965 -0.106 1.0 N 0.646 0.513 0.32580497728 gnomAD-4.0.0 2.60262E-05 None None None None N None 0 1.66667E-05 None 0 6.45995E-04 None 0 0 0 0 1.92135E-04
D/N 32822 Fn3-127 28 rs921446344 0.1801 0.655 1.0 N 0.626 0.364 0.288352970974 gnomAD-2.1.1 7.14E-06 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 7.82E-06 0
D/N 32822 Fn3-127 28 rs921446344 0.1801 0.655 1.0 N 0.626 0.364 0.288352970974 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
D/N 32822 Fn3-127 28 rs921446344 0.1801 0.655 1.0 N 0.626 0.364 0.288352970974 gnomAD-4.0.0 5.57708E-06 None None None None N None 1.33515E-05 0 None 0 0 None 0 0 6.78075E-06 0 0
D/G 32923 Fn3-128 28 None 0.4539 None 1.0 N 0.616 0.433 0.36355261348 gnomAD-4.0.0 6.84209E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
C/G 33024 Fn3-129 27 rs200744054 0.1466 None 0.27 N 0.42 0.21 0.49676076625 gnomAD-4.0.0 1.20035E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31254E-06 0 0
C/S 33024 Fn3-129 27 rs1692930141 0.1427 None 0.01 N 0.128 0.21 0.264081493735 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/S 33024 Fn3-129 27 rs1692930141 0.1427 None 0.01 N 0.128 0.21 0.264081493735 gnomAD-4.0.0 1.85918E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69531E-06 0 1.60123E-05
D/Y 33317 Fn3-130 28 rs1318907026 0.6243 -0.189 1.0 N 0.687 0.555 0.637732811552 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
D/Y 33317 Fn3-130 28 rs1318907026 0.6243 -0.189 1.0 N 0.687 0.555 0.637732811552 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 33317 Fn3-130 28 rs1318907026 0.6243 -0.189 1.0 N 0.687 0.555 0.637732811552 gnomAD-4.0.0 2.56257E-06 None None None None I None 3.38249E-05 0 None 0 0 None 0 0 0 0 0
S/G 33418 Fn3-131 27 rs1167149103 0.1383 None 0.999 N 0.45 0.319 0.313518423057 gnomAD-4.0.0 1.72325E-06 None None None None I None 0 2.59094E-05 None 0 0 None 0 0 0 0 0
S/T 33418 Fn3-131 27 None 0.0932 None 0.999 N 0.447 0.184 0.280987212366 gnomAD-4.0.0 7.06109E-07 None None None None I None 0 0 None 0 0 None 0 0 9.178E-07 0 0
S/F 33715 Fn3-132 27 rs755892166 0.2021 -1.035 0.667 N 0.47 0.169 0.404733080969 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
S/F 33715 Fn3-132 27 rs755892166 0.2021 -1.035 0.667 N 0.47 0.169 0.404733080969 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/F 33715 Fn3-132 27 rs755892166 0.2021 -1.035 0.667 N 0.47 0.169 0.404733080969 gnomAD-4.0.0 1.11533E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44088E-05 0 1.60041E-05
S/P 33715 Fn3-132 27 None 0.8058 None 0.132 N 0.418 0.179 0.128392430309 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.