Structural position:

  • Domain Type: Fn3
  • Aligned Position: 50
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
K/N 15800 Fn3-2 43 rs114145817 0.7193 0.386 0.801 N 0.394 0.21 0.181679512989 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
K/N 15800 Fn3-2 43 rs114145817 0.7193 0.386 0.801 N 0.394 0.21 0.181679512989 gnomAD-4.0.0 1.50613E-05 None None None None N None 2.99401E-05 0 None 0 0 None 0 0 1.70984E-05 0 3.31664E-05
E/K 15901 Fn3-3 43 rs530338718 0.2171 -0.244 0.978 N 0.513 0.311 0.371903410333 gnomAD-2.1.1 4.62E-06 None None None None N None 0 3.48E-05 None 0 0 None 0 None 0 0 0
E/K 15901 Fn3-3 43 rs530338718 0.2171 -0.244 0.978 N 0.513 0.311 0.371903410333 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
E/K 15901 Fn3-3 43 rs530338718 0.2171 -0.244 0.978 N 0.513 0.311 0.371903410333 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
E/K 15901 Fn3-3 43 rs530338718 0.2171 -0.244 0.978 N 0.513 0.311 0.371903410333 gnomAD-4.0.0 2.51869E-06 None None None None N None 0 3.67188E-05 None 0 0 None 0 0 1.70922E-06 0 0
V/I 16097 Fn3-4 43 rs550894260 0.0765 -0.414 0.055 N 0.412 0.037 0.248417906384 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
V/I 16097 Fn3-4 43 rs550894260 0.0765 -0.414 0.055 N 0.412 0.037 0.248417906384 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14766E-04 0
V/I 16097 Fn3-4 43 rs550894260 0.0765 -0.414 0.055 N 0.412 0.037 0.248417906384 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
V/I 16097 Fn3-4 43 rs550894260 0.0765 -0.414 0.055 N 0.412 0.037 0.248417906384 gnomAD-4.0.0 3.10125E-06 None None None None N None 0 0 None 0 2.23494E-05 None 0 0 0 4.39609E-05 0
R/C 16197 Fn3-5 43 rs748917057 0.436 -0.358 1.0 D 0.702 0.403 0.671359793744 gnomAD-2.1.1 1.43E-05 None None None None N None 8.28E-05 0 None 0 0 None 0 None 0 7.83E-06 1.40647E-04
R/C 16197 Fn3-5 43 rs748917057 0.436 -0.358 1.0 D 0.702 0.403 0.671359793744 gnomAD-3.1.2 5.27E-05 None None None None N None 7.25E-05 6.57E-05 0 0 0 None 0 0 2.94E-05 0 9.5511E-04
R/C 16197 Fn3-5 43 rs748917057 0.436 -0.358 1.0 D 0.702 0.403 0.671359793744 gnomAD-4.0.0 1.30249E-05 None None None None N None 5.34888E-05 5.00885E-05 None 0 0 None 0 0 6.78538E-06 1.099E-05 8.01462E-05
R/G 16197 Fn3-5 43 rs748917057 0.5823 -0.999 1.0 N 0.653 0.403 0.575644953977 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 16197 Fn3-5 43 rs748917057 0.5823 -0.999 1.0 N 0.653 0.403 0.575644953977 gnomAD-4.0.0 1.36949E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32126E-05 0
R/H 16197 Fn3-5 43 rs369826752 0.2548 -1.545 1.0 N 0.673 0.395 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
R/H 16197 Fn3-5 43 rs369826752 0.2548 -1.545 1.0 N 0.673 0.395 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/A 16492 Fn3-7 43 None 0.1177 None 0.767 N 0.491 0.184 0.247872288689 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/A 16693 Fn3-9 43 rs927020149 0.6582 -1.364 0.099 N 0.235 0.162 0.392855499163 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
V/A 16693 Fn3-9 43 rs927020149 0.6582 -1.364 0.099 N 0.235 0.162 0.392855499163 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 16693 Fn3-9 43 rs927020149 0.6582 -1.364 0.099 N 0.235 0.162 0.392855499163 gnomAD-4.0.0 5.58201E-06 None None None None N None 0 0 None 0 0 None 0 0 7.63236E-06 0 0
V/I 16693 Fn3-9 43 rs377141765 0.1331 -0.524 0.906 N 0.503 0.162 None gnomAD-2.1.1 2.16E-05 None None None None N None 0 2.84E-05 None 9.75E-05 0 None 3.27E-05 None 0 2.38E-05 0
V/I 16693 Fn3-9 43 rs377141765 0.1331 -0.524 0.906 N 0.503 0.162 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 4.42E-05 2.07211E-04 0
V/I 16693 Fn3-9 43 rs377141765 0.1331 -0.524 0.906 N 0.503 0.162 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
V/I 16693 Fn3-9 43 rs377141765 0.1331 -0.524 0.906 N 0.503 0.162 None gnomAD-4.0.0 3.53491E-05 None None None None N None 0 3.33823E-05 None 3.38112E-05 0 None 0 0 4.49461E-05 1.09844E-05 0
V/A 16894 Fn3-11 43 rs1270525854 0.1073 -0.957 0.001 N 0.159 0.116 0.243972157842 gnomAD-2.1.1 7.17E-06 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 7.87E-06 0
V/A 16894 Fn3-11 43 rs1270525854 0.1073 -0.957 0.001 N 0.159 0.116 0.243972157842 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 16894 Fn3-11 43 rs1270525854 0.1073 -0.957 0.001 N 0.159 0.116 0.243972157842 gnomAD-4.0.0 4.33989E-06 None None None None N None 1.33561E-05 0 None 0 2.23584E-05 None 0 0 4.23967E-06 0 0
V/I 16894 Fn3-11 43 rs754878640 0.089 -0.452 0.517 N 0.404 0.162 0.290590437066 gnomAD-2.1.1 7.17E-06 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 7.87E-06 0
V/I 16894 Fn3-11 43 rs754878640 0.089 -0.452 0.517 N 0.404 0.162 0.290590437066 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 16894 Fn3-11 43 rs754878640 0.089 -0.452 0.517 N 0.404 0.162 0.290590437066 gnomAD-4.0.0 1.23998E-06 None None None None N None 0 1.66839E-05 None 0 0 None 0 0 8.47939E-07 0 0
V/L 16894 Fn3-11 43 rs754878640 0.2416 -0.408 0.349 N 0.396 0.165 0.207176502487 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
V/L 16894 Fn3-11 43 rs754878640 0.2416 -0.408 0.349 N 0.396 0.165 0.207176502487 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 16894 Fn3-11 43 rs754878640 0.2416 -0.408 0.349 N 0.396 0.165 0.207176502487 gnomAD-4.0.0 4.33992E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08763E-06 0 1.60226E-05
A/G 17089 Fn3-12 43 None 0.4017 None 1.0 N 0.588 0.371 0.370051654043 gnomAD-4.0.0 1.59282E-06 None None None None N None 0 0 None 0 2.7767E-05 None 0 0 0 0 0
K/E 17189 Fn3-13 43 rs727503618 0.2904 0.247 0.999 N 0.697 0.421 0.399449838166 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/E 17411 Fn3-14 43 rs1243357204 0.1735 -0.053 0.425 N 0.326 0.251 0.326345978581 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
K/E 17411 Fn3-14 43 rs1243357204 0.1735 -0.053 0.425 N 0.326 0.251 0.326345978581 gnomAD-4.0.0 1.59381E-06 None None None None N None 0 0 None 0 2.78847E-05 None 0 0 0 0 0
K/M 17411 Fn3-14 43 rs1381230857 0.1496 0.302 0.975 N 0.453 0.425 0.486636631601 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/M 17411 Fn3-14 43 rs1381230857 0.1496 0.302 0.975 N 0.453 0.425 0.486636631601 gnomAD-4.0.0 1.36935E-06 None None None None N None 0 0 None 0 0 None 0 3.47222E-04 0 0 0
V/A 17611 Fn3-16 43 rs781744658 0.1109 -1.299 None N 0.167 0.134 0.284150004643 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/A 17611 Fn3-16 43 rs781744658 0.1109 -1.299 None N 0.167 0.134 0.284150004643 gnomAD-4.0.0 4.77852E-06 None None None None N None 5.67086E-05 2.28791E-05 None 0 0 None 0 0 2.86138E-06 0 0
V/F 17611 Fn3-16 43 rs748265704 0.217 None 0.655 N 0.462 0.261 0.570441715299 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/F 17611 Fn3-16 43 rs748265704 0.217 None 0.655 N 0.462 0.261 0.570441715299 gnomAD-4.0.0 6.58224E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47219E-05 0 0
V/I 17611 Fn3-16 43 rs748265704 0.0919 -0.577 0.001 N 0.185 0.077 None gnomAD-2.1.1 1.43E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 2.35E-05 0
V/I 17611 Fn3-16 43 rs748265704 0.0919 -0.577 0.001 N 0.185 0.077 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 4.42E-05 0 0
V/I 17611 Fn3-16 43 rs748265704 0.0919 -0.577 0.001 N 0.185 0.077 None gnomAD-4.0.0 1.24004E-05 None None None None N None 2.67301E-05 1.66861E-05 None 0 0 None 0 0 1.35672E-05 0 1.60231E-05
H/Q 17904 Fn3-18 43 rs2054588188 0.2507 None 0.016 N 0.127 0.163 0.0297737177859 gnomAD-4.0.0 1.59435E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03049E-05
A/G 18107 Fn3-19 43 rs794729457 0.1748 None 0.98 N 0.548 0.243 0.236890367714 gnomAD-4.0.0 3.18959E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72971E-06 0 0
E/K 18208 Fn3-20 43 rs575533984 0.2286 -0.419 0.001 N 0.131 0.253 0.221734844693 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 1.65837E-04
E/K 18208 Fn3-20 43 rs575533984 0.2286 -0.419 0.001 N 0.131 0.253 0.221734844693 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
E/K 18208 Fn3-20 43 rs575533984 0.2286 -0.419 0.001 N 0.131 0.253 0.221734844693 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/K 18208 Fn3-20 43 rs575533984 0.2286 -0.419 0.001 N 0.131 0.253 0.221734844693 gnomAD-4.0.0 6.20001E-06 None None None None N None 0 1.66744E-05 None 0 0 None 0 0 1.6961E-06 7.6918E-05 0
I/M 18521 Fn3-22 43 rs887160734 0.0927 None 0.627 N 0.461 0.095 0.286081765059 gnomAD-4.0.0 6.84541E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65755E-05
I/T 18521 Fn3-22 43 rs538872534 0.0886 -1.582 0.324 N 0.379 0.271 None gnomAD-2.1.1 1.61E-05 None None None None N None 6.47E-05 2.9E-05 None 0 0 None 0 None 0 1.78E-05 0
I/T 18521 Fn3-22 43 rs538872534 0.0886 -1.582 0.324 N 0.379 0.271 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.42E-05 1.97031E-04 0 0 0 None 0 0 0 0 0
I/T 18521 Fn3-22 43 rs538872534 0.0886 -1.582 0.324 N 0.379 0.271 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
I/T 18521 Fn3-22 43 rs538872534 0.0886 -1.582 0.324 N 0.379 0.271 None gnomAD-4.0.0 9.92036E-06 None None None None N None 4.00331E-05 5.00734E-05 None 0 2.23834E-05 None 0 1.65125E-04 5.93559E-06 0 1.60149E-05
I/V 18521 Fn3-22 43 None 0.0577 None None N 0.138 0.041 0.210429274316 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86144E-06 0 0
T/P 18626 Fn3-23 48 rs762549682 0.1361 -0.409 None N 0.285 0.118 0.209622950755 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/P 18626 Fn3-23 48 rs762549682 0.1361 -0.409 None N 0.285 0.118 0.209622950755 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/P 18626 Fn3-23 48 rs762549682 0.1361 -0.409 None N 0.285 0.118 0.209622950755 gnomAD-4.0.0 2.56465E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79092E-06 0 0
T/S 18626 Fn3-23 48 None 0.0881 None 0.012 N 0.349 0.064 0.104622674875 gnomAD-4.0.0 1.59276E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86123E-06 0 0
A/S 18827 Fn3-24 44 rs1280578786 0.1106 -1.221 0.625 N 0.408 0.111 0.159798565429 gnomAD-2.1.1 3.19E-05 None None None None N None 1.1489E-04 0 None 0 0 None 0 None 0 0 0
A/S 18827 Fn3-24 44 rs1280578786 0.1106 -1.221 0.625 N 0.408 0.111 0.159798565429 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
A/S 18827 Fn3-24 44 rs1280578786 0.1106 -1.221 0.625 N 0.408 0.111 0.159798565429 gnomAD-4.0.0 1.31591E-05 None None None None N None 4.83092E-05 0 None 0 0 None 0 0 0 0 0
A/T 18827 Fn3-24 44 rs1280578786 0.1085 None 0.801 N 0.399 0.118 0.17948927462 gnomAD-4.0.0 1.37184E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00563E-07 0 1.66041E-05
A/V 18827 Fn3-24 44 None 0.1478 None 0.891 N 0.387 0.214 0.252681307341 gnomAD-4.0.0 4.8012E-06 None None None None N None 0 0 None 0 0 None 0 0 6.30401E-06 0 0
E/D 19030 Fn3-26 43 rs1402903802 0.1531 -0.779 0.997 N 0.43 0.127 0.336892272479 gnomAD-2.1.1 1.23E-05 None None None None N None 0 0 None 0 0 None 3.46E-05 None 0 1.79E-05 0
E/D 19030 Fn3-26 43 rs1402903802 0.1531 -0.779 0.997 N 0.43 0.127 0.336892272479 gnomAD-4.0.0 6.42224E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86875E-06 4.41826E-05 0
E/G 19030 Fn3-26 43 None 0.1926 None 0.999 N 0.587 0.199 0.482209950775 gnomAD-4.0.0 6.86858E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00559E-07 0 0
E/K 19030 Fn3-26 43 rs966403005 0.2001 None 0.997 N 0.473 0.298 0.413241256734 gnomAD-4.0.0 2.74775E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60223E-06 0 0
I/F 19326 Fn3-28 43 None 0.3762 None 0.998 N 0.703 0.268 0.499985177359 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/M 19326 Fn3-28 43 rs763120020 0.1496 -0.576 0.998 N 0.686 0.18 0.45470266194 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/M 19326 Fn3-28 43 rs763120020 0.1496 -0.576 0.998 N 0.686 0.18 0.45470266194 gnomAD-4.0.0 3.42184E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49818E-06 0 0
I/T 19326 Fn3-28 43 rs766571281 0.2225 -1.675 0.989 N 0.596 0.441 0.564429724435 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 5.58E-05 None 0 None 4.64E-05 1.78E-05 0
I/T 19326 Fn3-28 43 rs766571281 0.2225 -1.675 0.989 N 0.596 0.441 0.564429724435 gnomAD-4.0.0 6.15935E-06 None None None None N None 2.98954E-05 0 None 0 5.04592E-05 None 1.87266E-05 0 3.59856E-06 0 1.65684E-05
T/A 19620 Fn3-30 42 rs1215190215 0.1272 -1.175 0.999 N 0.559 0.241 0.276065633971 gnomAD-2.1.1 8.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 1.65673E-04
T/A 19620 Fn3-30 42 rs1215190215 0.1272 -1.175 0.999 N 0.559 0.241 0.276065633971 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31096E-04 0 0 0 None 0 0 0 0 0
T/A 19620 Fn3-30 42 rs1215190215 0.1272 -1.175 0.999 N 0.559 0.241 0.276065633971 gnomAD-4.0.0 3.71926E-06 None None None None N None 0 6.67312E-05 None 0 0 None 0 0 1.69556E-06 0 0
T/P 19620 Fn3-30 42 None 0.1963 None 1.0 N 0.679 0.45 0.355450299083 gnomAD-4.0.0 1.36873E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79923E-06 0 0
T/S 19620 Fn3-30 42 None 0.2061 None 0.999 N 0.566 0.203 0.284539287134 gnomAD-4.0.0 3.18425E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71955E-06 0 0
V/A 19722 Fn3-31 43 rs116592778 0.0753 -0.728 0.001 N 0.141 0.126 None gnomAD-2.1.1 1.2615E-03 None None None None N None 1.29371E-02 7.07294E-04 None 0 0 None 0 None 0 8.61E-05 5.61956E-04
V/A 19722 Fn3-31 43 rs116592778 0.0753 -0.728 0.001 N 0.141 0.126 None gnomAD-3.1.2 3.80926E-03 None None None None N None 1.31388E-02 1.18079E-03 0 0 0 None 0 0 8.83E-05 0 5.26316E-03
V/A 19722 Fn3-31 43 rs116592778 0.0753 -0.728 0.001 N 0.141 0.126 None 1000 genomes 4.39297E-03 None None None None N None 1.66E-02 0 None None 0 0 None None None 0 None
V/A 19722 Fn3-31 43 rs116592778 0.0753 -0.728 0.001 N 0.141 0.126 None gnomAD-4.0.0 7.04069E-04 None None None None N None 1.29508E-02 8.16993E-04 None 6.7595E-05 0 None 0 8.25355E-04 3.56052E-05 0 1.07255E-03
V/G 19722 Fn3-31 43 None 0.1578 None 0.201 N 0.445 0.268 0.538237646413 gnomAD-4.0.0 6.84293E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99573E-07 0 0
V/A 19919 Fn3-32 43 None 0.1339 None 0.061 N 0.143 0.145 0.256793551483 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/A 20019 Fn3-33 43 None 0.1376 None 0.645 N 0.638 0.316 0.430694319191 gnomAD-4.0.0 6.8439E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15958E-05 0
E/D 20019 Fn3-33 43 rs1342395614 0.1308 None 0.002 N 0.278 0.064 0.0954503805726 gnomAD-4.0.0 6.84391E-06 None None None None N None 0 2.23784E-05 None 0 0 None 0 0 7.19695E-06 0 1.657E-05
E/G 20019 Fn3-33 43 rs1301342171 0.2446 None 0.645 N 0.587 0.293 0.464953486513 gnomAD-4.0.0 6.8439E-06 None None None None N None 0 2.23784E-05 None 0 0 None 0 0 5.39764E-06 2.31916E-05 1.65706E-05
E/K 20019 Fn3-33 43 rs201487340 0.2648 0.19 0.645 N 0.605 0.267 None gnomAD-2.1.1 1.49528E-03 None None None None N None 1.57982E-02 7.36961E-04 None 0 0 None 3.27E-05 None 0 3.92E-05 5.62746E-04
E/K 20019 Fn3-33 43 rs201487340 0.2648 0.19 0.645 N 0.605 0.267 None gnomAD-3.1.2 4.11157E-03 None None None None N None 1.45333E-02 9.84252E-04 0 0 0 None 0 0 2.94E-05 0 2.87081E-03
E/K 20019 Fn3-33 43 rs201487340 0.2648 0.19 0.645 N 0.605 0.267 None 1000 genomes 1.79712E-03 None None None None N None 6.8E-03 0 None None 0 0 None None None 0 None
E/K 20019 Fn3-33 43 rs201487340 0.2648 0.19 0.645 N 0.605 0.267 None gnomAD-4.0.0 7.9093E-04 None None None None N None 1.54946E-02 7.00631E-04 None 0 0 None 0 1.65125E-04 1.1021E-05 2.19626E-05 8.96603E-04
T/K 20214 Fn3-34 44 None 0.1393 None 0.379 N 0.395 0.246 0.243972157842 gnomAD-4.0.0 1.59223E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43308E-05 0
T/S 20214 Fn3-34 44 rs1358705514 0.1114 None 0.007 N 0.143 0.098 0.144782658237 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 20214 Fn3-34 44 rs1358705514 0.1114 None 0.007 N 0.143 0.098 0.144782658237 gnomAD-4.0.0 5.12719E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57703E-06 0 0
V/I 20313 Fn3-35 43 rs773846604 0.0612 -0.353 None N 0.119 0.158 0.132336055621 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/I 20313 Fn3-35 43 rs773846604 0.0612 -0.353 None N 0.119 0.158 0.132336055621 gnomAD-4.0.0 2.74859E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61342E-06 0 0
P/S 20413 Fn3-36 43 rs1318733792 0.0989 -1.042 None N 0.185 0.1 0.0666544352282 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
P/S 20413 Fn3-36 43 rs1318733792 0.0989 -1.042 None N 0.185 0.1 0.0666544352282 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 20413 Fn3-36 43 rs1318733792 0.0989 -1.042 None N 0.185 0.1 0.0666544352282 gnomAD-4.0.0 6.58111E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47154E-05 0 0
P/S 20611 Fn3-37 43 None 0.4209 None 1.0 N 0.765 0.348 0.318540980066 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 3.66327E-05
T/I 20906 Fn3-39 43 rs1386139408 0.5581 -0.007 0.497 N 0.479 0.182 0.257786959452 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.69E-05 None 0 None 0 0 0
T/I 20906 Fn3-39 43 rs1386139408 0.5581 -0.007 0.497 N 0.479 0.182 0.257786959452 gnomAD-4.0.0 6.8533E-07 None None None None N None 0 0 None 0 2.53614E-05 None 0 0 0 0 0
T/K 20906 Fn3-39 43 None 0.6182 None 0.124 N 0.479 0.14 0.194818534648 gnomAD-4.0.0 2.74132E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59906E-06 0 0
T/R 20906 Fn3-39 43 rs1386139408 0.585 -0.931 0.497 N 0.501 0.209 0.405700215632 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
T/R 20906 Fn3-39 43 rs1386139408 0.585 -0.931 0.497 N 0.501 0.209 0.405700215632 gnomAD-4.0.0 6.8533E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99766E-07 0 0
A/E 21308 Fn3-42 43 rs772717263 0.3905 None 0.949 N 0.526 0.325 0.308904156042 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/E 21308 Fn3-42 43 rs772717263 0.3905 None 0.949 N 0.526 0.325 0.308904156042 gnomAD-4.0.0 4.06057E-06 None None None None N None 0 0 None 0 0 None 0 0 4.82002E-06 0 0
E/K 21408 Fn3-43 43 None 0.3953 None 0.896 N 0.53 0.231 0.28058544554 gnomAD-4.0.0 1.59261E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86102E-06 0 0
V/I 21602 Fn3-44 44 None 0.0793 None 0.4 N 0.247 0.204 0.377097596864 gnomAD-4.0.0 6.84345E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99628E-07 0 0
V/L 21602 Fn3-44 44 rs2048571659 0.2404 None 0.911 N 0.467 0.232 0.368743488249 gnomAD-4.0.0 4.10606E-06 None None None None N None 2.98989E-05 0 None 0 0 None 0 0 0 0 8.28638E-05
R/I 21701 Fn3-45 43 rs756852802 0.7173 0.327 1.0 N 0.707 0.384 0.594763190098 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
R/I 21701 Fn3-45 43 rs756852802 0.7173 0.327 1.0 N 0.707 0.384 0.594763190098 gnomAD-4.0.0 6.84401E-07 None None None None N None 0 0 None 0 2.52678E-05 None 0 0 0 0 0
R/T 21701 Fn3-45 43 rs756852802 0.8148 -0.311 1.0 N 0.641 0.385 0.516715673709 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
R/T 21701 Fn3-45 43 rs756852802 0.8148 -0.311 1.0 N 0.641 0.385 0.516715673709 gnomAD-4.0.0 1.3688E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7993E-06 0 0
L/P 21799 Fn3-46 43 rs1260259069 0.736 -1.145 0.235 N 0.554 0.333 0.685930098433 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 3.35E-05 None 0 0 0
L/P 21799 Fn3-46 43 rs1260259069 0.736 -1.145 0.235 N 0.554 0.333 0.685930098433 gnomAD-4.0.0 1.59838E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44371E-05 0
L/R 21799 Fn3-46 43 None 0.4226 None 0.997 N 0.741 0.43 0.771267463846 gnomAD-4.0.0 3.19676E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.88742E-05 0
A/T 22198 Fn3-49 43 rs2047776872 0.087 None 0.032 N 0.305 0.188 0.200317383148 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 22198 Fn3-49 43 rs2047776872 0.087 None 0.032 N 0.305 0.188 0.200317383148 gnomAD-4.0.0 2.56623E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79251E-06 0 0
S/T 22686 Fn3-52 44 None 0.0849 None 0.007 N 0.137 0.049 0.0762999501168 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
T/I 23082 Fn3-55 43 None 0.8762 None 0.976 N 0.557 0.367 0.408307896497 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 23181 Fn3-56 43 None 0.2549 None 0.822 N 0.555 0.24 0.282575091529 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 23282 Fn3-57 43 rs876658079 0.0803 None 0.081 N 0.319 0.167 0.38225645794 gnomAD-4.0.0 2.76242E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61581E-06 0 0
A/E 23477 Fn3-58 43 None 0.7277 None 0.822 N 0.511 0.28 0.353548585375 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 23477 Fn3-58 43 rs763988813 0.1183 -1.129 0.698 N 0.533 0.096 0.241078983079 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 1.6342E-04 None 0 0 0
A/T 23477 Fn3-58 43 rs763988813 0.1183 -1.129 0.698 N 0.533 0.096 0.241078983079 gnomAD-4.0.0 8.21163E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79911E-06 1.15945E-04 0
K/R 23574 Fn3-59 43 rs781090352 0.0912 0.192 0.569 N 0.514 0.173 0.307016933798 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/R 23574 Fn3-59 43 rs781090352 0.0912 0.192 0.569 N 0.514 0.173 0.307016933798 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 23769 Fn3-60 44 rs776889753 0.1164 -0.979 0.999 N 0.572 0.299 0.327419511103 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 0
T/A 23769 Fn3-60 44 rs776889753 0.1164 -0.979 0.999 N 0.572 0.299 0.327419511103 gnomAD-4.0.0 1.43761E-05 None None None None N None 0 0 None 0 0 None 1.87652E-05 0 1.70956E-05 0 1.65766E-05
T/S 23769 Fn3-60 44 rs776889753 0.1856 -1.298 0.999 N 0.596 0.206 0.310458034454 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.7E-05 0
T/S 23769 Fn3-60 44 rs776889753 0.1856 -1.298 0.999 N 0.596 0.206 0.310458034454 gnomAD-4.0.0 2.05372E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.4806E-05 0
R/Q 23868 Fn3-61 43 rs763316990 0.1604 0.084 0.98 N 0.556 0.151 0.245101548738 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
R/Q 23868 Fn3-61 43 rs763316990 0.1604 0.084 0.98 N 0.556 0.151 0.245101548738 gnomAD-4.0.0 7.52714E-06 None None None None N None 0 0 None 3.8276E-05 2.52067E-05 None 1.87266E-05 0 5.39745E-06 2.31895E-05 0
L/P 23966 Fn3-62 43 None 0.8944 None 0.99 N 0.736 0.512 0.773781150904 gnomAD-4.0.0 1.59242E-06 None None None None N None 0 0 None 0 2.78319E-05 None 0 0 0 0 0
K/I 24264 Fn3-64 43 rs745449959 0.5252 0.54 0.018 N 0.488 0.226 0.345859378078 gnomAD-2.1.1 5.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.09E-05 0
K/I 24264 Fn3-64 43 rs745449959 0.5252 0.54 0.018 N 0.488 0.226 0.345859378078 gnomAD-4.0.0 7.18776E-07 None None None None N None 0 0 None 0 0 None 0 0 9.27754E-07 0 0
P/S 24365 Fn3-65 43 None 0.1606 None 0.805 N 0.521 0.271 0.285316908763 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
S/L 24561 Fn3-66 43 None 0.2148 None 0.911 N 0.617 0.361 0.445410361449 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/E 24658 Fn3-67 43 None 0.424 None 0.032 N 0.279 0.209 0.224531998449 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85927E-06 0 0
T/I 24851 Fn3-68 44 rs756862019 0.4928 -0.405 1.0 D 0.667 0.455 0.40017627803 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.69E-05 0
T/I 24851 Fn3-68 44 rs756862019 0.4928 -0.405 1.0 D 0.667 0.455 0.40017627803 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 24851 Fn3-68 44 rs756862019 0.4928 -0.405 1.0 D 0.667 0.455 0.40017627803 gnomAD-4.0.0 8.05886E-06 None None None None N None 1.3354E-05 0 None 0 0 None 0 0 1.01731E-05 0 0
T/N 24851 Fn3-68 44 None 0.4661 None 1.0 N 0.717 0.336 0.36076525451 gnomAD-4.0.0 2.05332E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6988E-06 0 0
L/S 25048 Fn3-70 43 rs774327169 0.7131 -1.767 0.997 N 0.656 0.444 0.683575195277 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
L/S 25048 Fn3-70 43 rs774327169 0.7131 -1.767 0.997 N 0.656 0.444 0.683575195277 gnomAD-4.0.0 6.15904E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09671E-06 0 0
T/A 25247 Fn3-71 44 rs577368021 0.2757 -0.736 0.273 N 0.527 0.222 0.226586394389 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 25247 Fn3-71 44 rs577368021 0.2757 -0.736 0.273 N 0.527 0.222 0.226586394389 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
T/A 25247 Fn3-71 44 rs577368021 0.2757 -0.736 0.273 N 0.527 0.222 0.226586394389 gnomAD-4.0.0 6.57851E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47193E-05 0 0
T/I 25247 Fn3-71 44 None 0.7116 None 0.013 N 0.335 0.24 0.259761712551 gnomAD-4.0.0 6.84455E-07 None None None None N None 0 0 None 0 2.52896E-05 None 0 0 0 0 0
T/N 25247 Fn3-71 44 None 0.4113 None 0.864 N 0.567 0.285 0.321672782286 gnomAD-4.0.0 1.36891E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99586E-07 0 1.6575E-05
V/L 25447 Fn3-73 43 rs374106281 0.1202 -0.506 None N 0.141 0.106 0.278143212241 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/L 25447 Fn3-73 43 rs374106281 0.1202 -0.506 None N 0.141 0.106 0.278143212241 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 25447 Fn3-73 43 rs374106281 0.1202 -0.506 None N 0.141 0.106 0.278143212241 gnomAD-4.0.0 1.30178E-05 None None None None N None 0 1.66789E-05 None 0 0 None 0 0 1.6955E-05 0 0
A/G 25643 Fn3-74 43 None 0.2496 None 0.78 N 0.465 0.208 0.226586394389 gnomAD-4.0.0 1.60351E-06 None None None None N None 0 0 None 0 2.77608E-05 None 0 0 0 0 0
A/T 25643 Fn3-74 43 None 0.1106 None 0.103 N 0.321 0.13 0.144782658237 gnomAD-4.0.0 1.60365E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45488E-05 0
K/Q 25740 Fn3-75 43 None 0.169 None 0.998 N 0.679 0.422 0.28058544554 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85954E-06 0 0
T/K 25933 Fn3-76 44 rs1475741583 0.6351 -0.875 0.142 N 0.309 0.352 0.26547132957 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/K 25933 Fn3-76 44 rs1475741583 0.6351 -0.875 0.142 N 0.309 0.352 0.26547132957 gnomAD-4.0.0 2.47943E-06 None None None None N None 4.00652E-05 0 None 0 0 None 0 0 0 0 1.60174E-05
T/A 26329 Fn3-79 44 rs1443062175 0.4867 -0.985 0.825 N 0.534 0.325 0.201204373187 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/A 26329 Fn3-79 44 rs1443062175 0.4867 -0.985 0.825 N 0.534 0.325 0.201204373187 gnomAD-4.0.0 1.36865E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
A/T 26529 Fn3-81 43 None 0.087 None 0.822 N 0.545 0.225 0.304108284078 gnomAD-4.0.0 4.10648E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49757E-06 0 1.65695E-05
S/L 26725 Fn3-82 43 rs772603198 0.2394 0.148 1.0 N 0.643 0.486 0.356484672536 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/L 26725 Fn3-82 43 rs772603198 0.2394 0.148 1.0 N 0.643 0.486 0.356484672536 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85907E-06 0 0
S/P 26725 Fn3-82 43 None 0.7327 None 0.999 N 0.687 0.555 0.339074221408 gnomAD-4.0.0 2.05284E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69866E-06 0 0
K/N 27114 Fn3-85 43 None 0.8585 None 0.967 D 0.474 0.295 0.30212335484 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/Q 27114 Fn3-85 43 rs962009573 0.3627 None 0.967 N 0.507 0.319 0.340992353424 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/Q 27114 Fn3-85 43 rs962009573 0.3627 None 0.967 N 0.507 0.319 0.340992353424 gnomAD-4.0.0 4.34183E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93662E-06 0 0
T/K 27412 Fn3-87 44 rs201489661 0.7272 -0.75 0.142 N 0.324 0.355 None gnomAD-2.1.1 3.94239E-04 None None None None N None 0 0 None 6.47024E-03 0 None 7.84314E-04 None 0 5.34E-05 4.97347E-04
T/K 27412 Fn3-87 44 rs201489661 0.7272 -0.75 0.142 N 0.324 0.355 None gnomAD-3.1.2 1.90652E-04 None None None None N None 2.41E-05 0 0 5.4755E-03 0 None 0 0 4.41E-05 1.03691E-03 4.77555E-04
T/K 27412 Fn3-87 44 rs201489661 0.7272 -0.75 0.142 N 0.324 0.355 None gnomAD-4.0.0 2.37958E-04 None None None None N None 1.33301E-05 0 None 7.26302E-03 0 None 0 0 3.22104E-05 1.02115E-03 5.92152E-04
T/R 27412 Fn3-87 44 rs201489661 0.7121 -0.506 0.976 D 0.583 0.4 0.49590494691 gnomAD-2.1.1 4.02E-05 None None None None N None 0 0 None 0 0 None 3.26797E-04 None 0 0 0
T/R 27412 Fn3-87 44 rs201489661 0.7121 -0.506 0.976 D 0.583 0.4 0.49590494691 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 0 1.03691E-03 0
T/R 27412 Fn3-87 44 rs201489661 0.7121 -0.506 0.976 D 0.583 0.4 0.49590494691 gnomAD-4.0.0 1.61117E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.85482E-04 0
A/D 27612 Fn3-89 43 None 0.2392 None 0.015 N 0.352 0.128 0.366277470483 gnomAD-4.0.0 2.0528E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69856E-06 0 0
K/E 27905 Fn3-91 43 rs879057080 0.3015 None 0.997 N 0.697 0.464 None gnomAD-4.0.0 1.59339E-06 None None None None N None 5.66765E-05 0 None 0 0 None 0 0 0 0 0
T/A 28097 Fn3-92 43 None 0.1296 None 0.014 N 0.237 0.144 0.112648838833 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/S 28196 Fn3-93 43 rs773466308 0.8033 -0.056 0.684 N 0.407 0.214 0.249502417897 gnomAD-2.1.1 1.61E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 2.67E-05 0
R/S 28196 Fn3-93 43 rs773466308 0.8033 -0.056 0.684 N 0.407 0.214 0.249502417897 gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 1.0289E-04 0 0
R/S 28196 Fn3-93 43 rs773466308 0.8033 -0.056 0.684 N 0.407 0.214 0.249502417897 gnomAD-4.0.0 1.67369E-05 None None None None N None 2.66994E-05 1.66845E-05 None 0 0 None 0 0 1.86516E-05 0 3.20318E-05
L/V 28294 Fn3-94 43 rs747855990 0.2028 -1.461 0.999 N 0.561 0.152 0.471941563831 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
L/V 28294 Fn3-94 43 rs747855990 0.2028 -1.461 0.999 N 0.561 0.152 0.471941563831 gnomAD-4.0.0 1.59139E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85811E-06 0 0
T/A 28493 Fn3-95 44 rs369907507 0.172 -1.17 0.999 N 0.549 0.43 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/A 28493 Fn3-95 44 rs369907507 0.172 -1.17 0.999 N 0.549 0.43 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
T/A 28493 Fn3-95 44 rs369907507 0.172 -1.17 0.999 N 0.549 0.43 None gnomAD-4.0.0 4.40021E-05 None None None None N None 1.33451E-05 0 None 0 0 None 0 0 5.84851E-05 0 1.60128E-05
T/K 28493 Fn3-95 44 rs1703288626 0.4277 None 1.0 N 0.712 0.407 0.48286525802 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/K 28493 Fn3-95 44 rs1703288626 0.4277 None 1.0 N 0.712 0.407 0.48286525802 gnomAD-4.0.0 3.84433E-06 None None None None N None 1.69159E-05 0 None 0 0 None 1.57228E-05 0 2.39305E-06 0 0
K/R 28592 Fn3-96 43 None 0.1115 None 0.014 N 0.261 0.098 0.201204373187 gnomAD-4.0.0 4.77445E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.29898E-05 0
S/C 28693 Fn3-97 43 rs893693576 0.1079 None 0.896 N 0.475 0.276 0.318252033908 gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
S/C 28693 Fn3-97 43 rs893693576 0.1079 None 0.896 N 0.475 0.276 0.318252033908 gnomAD-4.0.0 5.57772E-06 None None None None N None 1.20141E-04 0 None 0 0 None 0 0 0 0 0
A/T 28887 Fn3-98 43 rs1377533598 0.2484 None 0.928 N 0.709 0.222 0.18274738541 gnomAD-4.0.0 2.73696E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59805E-06 0 0
T/I 29180 Fn3-100 44 rs375586936 0.4424 None 1.0 N 0.671 0.473 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 29180 Fn3-100 44 rs375586936 0.4424 None 1.0 N 0.671 0.473 None gnomAD-4.0.0 1.8588E-06 None None None None N None 3.99744E-05 0 None 0 0 None 0 0 0 0 0
R/K 29279 Fn3-101 43 None 0.1835 None 0.219 N 0.202 0.159 0.224531998449 gnomAD-4.0.0 6.84164E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
R/S 29279 Fn3-101 43 rs184963961 0.869 -0.564 0.98 N 0.629 0.33 0.236890367714 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
R/T 29279 Fn3-101 43 rs773541746 0.6964 -0.252 0.99 N 0.583 0.332 0.344483371355 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
R/T 29279 Fn3-101 43 rs773541746 0.6964 -0.252 0.99 N 0.583 0.332 0.344483371355 gnomAD-4.0.0 6.15748E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09479E-06 0 0
L/F 29377 Fn3-102 43 rs908918470 0.2075 -1.617 0.901 N 0.517 0.177 0.593429312994 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
L/F 29377 Fn3-102 43 rs908918470 0.2075 -1.617 0.901 N 0.517 0.177 0.593429312994 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/F 29377 Fn3-102 43 rs908918470 0.2075 -1.617 0.901 N 0.517 0.177 0.593429312994 gnomAD-4.0.0 3.84335E-06 None None None None N None 5.07271E-05 0 None 0 0 None 0 0 0 0 0
T/R 29576 Fn3-103 44 rs1700623048 0.5577 None 1.0 N 0.658 0.413 0.623315389809 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/R 29576 Fn3-103 44 rs1700623048 0.5577 None 1.0 N 0.658 0.413 0.623315389809 gnomAD-4.0.0 6.5735E-06 None None None None N None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
K/R 29675 Fn3-104 43 None 0.0788 None 0.999 N 0.598 0.334 0.438806408302 gnomAD-4.0.0 1.59106E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85791E-06 0 0
G/E 29776 Fn3-105 43 None 0.1678 None 0.012 N 0.535 0.085 0.17948927462 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
A/V 29975 Fn3-106 43 rs117097948 0.2142 -0.323 0.994 N 0.549 0.278 None gnomAD-2.1.1 7.53E-05 None None None None N None 0 0 None 0 5.14403E-04 None 3.27011E-04 None 0 0 1.41163E-04
A/V 29975 Fn3-106 43 rs117097948 0.2142 -0.323 0.994 N 0.549 0.278 None gnomAD-3.1.2 5.26E-05 None None None None N None 0 0 0 0 7.7101E-04 None 0 0 0 8.29187E-04 0
A/V 29975 Fn3-106 43 rs117097948 0.2142 -0.323 0.994 N 0.549 0.278 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 2E-03 0 None None None 1E-03 None
A/V 29975 Fn3-106 43 rs117097948 0.2142 -0.323 0.994 N 0.549 0.278 None gnomAD-4.0.0 3.22485E-05 None None None None N None 0 0 None 0 2.67785E-04 None 0 1.65125E-04 2.54283E-06 3.73323E-04 3.20184E-05
K/R 30072 Fn3-107 43 None 0.0812 None 0.029 N 0.341 0.106 0.31411915649 gnomAD-4.0.0 1.59105E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85781E-06 0 0
T/A 30267 Fn3-108 44 rs377365979 0.0644 -1.101 None N 0.157 0.06 None gnomAD-2.1.1 2.14E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.68E-05 0
T/A 30267 Fn3-108 44 rs377365979 0.0644 -1.101 None N 0.157 0.06 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/A 30267 Fn3-108 44 rs377365979 0.0644 -1.101 None N 0.157 0.06 None gnomAD-4.0.0 5.5774E-06 None None None None N None 0 0 None 0 0 None 0 0 7.62859E-06 0 0
T/N 30267 Fn3-108 44 None 0.1539 None 0.117 N 0.389 0.284 0.254244900254 gnomAD-4.0.0 1.59141E-06 None None None None N None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
R/G 30366 Fn3-109 43 None 0.7379 None 1.0 N 0.625 0.332 0.508755544265 gnomAD-4.0.0 1.59113E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
R/I 30366 Fn3-109 43 None 0.7369 None 1.0 N 0.694 0.436 0.586756053714 gnomAD-4.0.0 1.59139E-06 None None None None I None 0 0 None 0 2.773E-05 None 0 0 0 0 0
T/N 30662 Fn3-111 44 rs2154148455 0.5101 None 1.0 N 0.709 0.484 0.473774312618 gnomAD-4.0.0 3.18293E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71726E-06 0 0
T/P 30662 Fn3-111 44 None 0.6415 None 1.0 N 0.647 0.565 0.449669948863 gnomAD-4.0.0 2.40064E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
T/S 30662 Fn3-111 44 None 0.3439 None 0.999 N 0.577 0.322 0.233785782151 gnomAD-4.0.0 1.59146E-06 None None None None N None 0 0 None 4.76781E-05 0 None 0 0 0 0 0
A/T 30863 Fn3-113 43 rs1175884597 0.0947 None 0.978 N 0.762 0.242 0.306695030598 gnomAD-4.0.0 3.18213E-06 None None None None N None 1.13109E-04 0 None 0 0 None 0 0 0 0 0
A/V 30863 Fn3-113 43 None 0.1269 None 0.928 N 0.699 0.3 0.356897458496 gnomAD-4.0.0 2.05253E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79886E-06 1.15937E-05 0
A/S 31058 Fn3-114 43 rs1232455758 0.1527 None 1.0 N 0.61 0.243 0.218845423259 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
A/S 31058 Fn3-114 43 rs1232455758 0.1527 None 1.0 N 0.61 0.243 0.218845423259 gnomAD-4.0.0 6.84185E-07 None None None None N None 2.98775E-05 0 None 0 0 None 0 0 0 0 0
A/T 31058 Fn3-114 43 rs1232455758 0.2291 -0.976 1.0 N 0.693 0.252 0.263140351381 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/T 31058 Fn3-114 43 rs1232455758 0.2291 -0.976 1.0 N 0.693 0.252 0.263140351381 gnomAD-4.0.0 6.15767E-06 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 7.19559E-06 0 0
A/V 31058 Fn3-114 43 None 0.2665 None 1.0 N 0.661 0.255 0.446510307777 gnomAD-4.0.0 1.5911E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
K/N 31155 Fn3-115 43 rs1351647298 0.5997 0.086 0.999 N 0.626 0.268 0.248417906384 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/N 31155 Fn3-115 43 rs1351647298 0.5997 0.086 0.999 N 0.626 0.268 0.248417906384 gnomAD-4.0.0 6.84177E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99444E-07 0 0
K/R 31155 Fn3-115 43 rs1230714355 0.1012 -0.036 0.998 N 0.539 0.229 0.446211707333 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/R 31155 Fn3-115 43 rs1230714355 0.1012 -0.036 0.998 N 0.539 0.229 0.446211707333 gnomAD-4.0.0 1.59109E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
S/L 31351 Fn3-116 44 rs794729536 0.1377 -0.077 1.0 N 0.665 0.411 0.529813890454 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/L 31351 Fn3-116 44 rs794729536 0.1377 -0.077 1.0 N 0.665 0.411 0.529813890454 gnomAD-4.0.0 1.36839E-05 None None None None N None 0 0 None 0 0 None 0 0 1.70894E-05 1.15934E-05 0
S/T 31351 Fn3-116 44 None 0.0913 None 0.999 N 0.566 0.325 0.277730125212 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 31450 Fn3-117 43 rs541040798 0.7184 -0.081 1.0 N 0.701 0.41 0.553833332621 gnomAD-2.1.1 3.24608E-04 None None None None N None 0 0 None 0 0 None 2.67956E-03 None 0 6.24E-05 1.40331E-04
R/C 31450 Fn3-117 43 rs541040798 0.7184 -0.081 1.0 N 0.701 0.41 0.553833332621 gnomAD-3.1.2 9.21E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 2.07641E-03 4.80307E-04
R/C 31450 Fn3-117 43 rs541040798 0.7184 -0.081 1.0 N 0.701 0.41 0.553833332621 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
R/C 31450 Fn3-117 43 rs541040798 0.7184 -0.081 1.0 N 0.701 0.41 0.553833332621 gnomAD-4.0.0 1.59878E-04 None None None None N None 0 0 None 0 4.45851E-05 None 0 1.64962E-04 2.37334E-05 2.3718E-03 1.76101E-04
R/H 31450 Fn3-117 43 rs751985617 0.5084 -1.003 0.998 N 0.511 0.414 0.374613414588 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/H 31450 Fn3-117 43 rs751985617 0.5084 -1.003 0.998 N 0.511 0.414 0.374613414588 gnomAD-4.0.0 3.421E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49738E-06 0 0
V/I 31548 Fn3-118 43 rs1697361370 0.0766 None 0.101 N 0.343 0.035 0.322230723748 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 31548 Fn3-118 43 rs1697361370 0.0766 None 0.101 N 0.343 0.035 0.322230723748 gnomAD-4.0.0 3.09865E-06 None None None None N None 0 1.66717E-05 None 0 0 None 0 0 2.54295E-06 0 1.60108E-05
K/R 31951 Fn3-121 43 None 0.0904 None 0.042 N 0.227 0.146 0.212008924253 gnomAD-4.0.0 1.59141E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
A/V 32147 Fn3-122 43 rs774531768 0.2416 -0.324 1.0 N 0.667 0.294 0.416202232284 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
A/V 32147 Fn3-122 43 rs774531768 0.2416 -0.324 1.0 N 0.667 0.294 0.416202232284 gnomAD-4.0.0 4.7805E-06 None None None None N None 0 0 None 0 8.33009E-05 None 0 0 0 0 0
A/V 32244 Fn3-123 43 None 0.0991 None 0.061 N 0.207 0.151 0.200317383148 gnomAD-4.0.0 1.59117E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85816E-06 0 0
A/S 32442 Fn3-124 44 rs778341120 0.1651 None 1.0 N 0.614 0.302 0.376393476264 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 32442 Fn3-124 44 rs778341120 0.1651 None 1.0 N 0.614 0.302 0.376393476264 gnomAD-4.0.0 1.85924E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54297E-06 0 0
A/T 32442 Fn3-124 44 rs778341120 0.2241 -0.984 1.0 N 0.672 0.417 None gnomAD-2.1.1 3.22E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 6.23E-05 0
A/T 32442 Fn3-124 44 rs778341120 0.2241 -0.984 1.0 N 0.672 0.417 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
A/T 32442 Fn3-124 44 rs778341120 0.2241 -0.984 1.0 N 0.672 0.417 None gnomAD-4.0.0 1.73529E-05 None None None None N None 5.34045E-05 0 None 0 0 None 0 0 1.78008E-05 0 4.80384E-05
V/L 32541 Fn3-125 43 rs771198352 0.2215 -0.265 0.91 N 0.406 0.138 0.545696997403 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65893E-04
V/L 32541 Fn3-125 43 rs771198352 0.2215 -0.265 0.91 N 0.406 0.138 0.545696997403 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 32541 Fn3-125 43 rs771198352 0.2215 -0.265 0.91 N 0.406 0.138 0.545696997403 gnomAD-4.0.0 4.33863E-06 None None None None N None 0 0 None 0 0 None 0 0 5.9341E-06 0 0
V/M 32541 Fn3-125 43 rs771198352 0.1604 -0.395 0.998 N 0.456 0.204 0.599423059063 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/M 32541 Fn3-125 43 rs771198352 0.1604 -0.395 0.998 N 0.456 0.204 0.599423059063 gnomAD-4.0.0 5.47474E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29725E-06 0 1.65728E-05
V/A 32642 Fn3-126 43 rs1575367028 0.0919 None 0.999 N 0.591 0.354 0.59360226722 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 2.77254E-05 None 0 0 0 0 0
V/E 32838 Fn3-127 44 None 0.4712 None 1.0 N 0.683 0.512 0.583209036909 gnomAD-4.0.0 6.84182E-07 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 0 0
V/L 32838 Fn3-127 44 rs200318160 0.3127 -0.888 0.997 N 0.563 0.31 0.405839309607 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.95E-05 0 None 0 None 0 0 0
V/L 32838 Fn3-127 44 rs200318160 0.3127 -0.888 0.997 N 0.563 0.31 0.405839309607 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 2.88018E-04 0 None 0 0 0 0 0
V/L 32838 Fn3-127 44 rs200318160 0.3127 -0.888 0.997 N 0.563 0.31 0.405839309607 gnomAD-4.0.0 2.05255E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47794E-05 0
V/M 32838 Fn3-127 44 None 0.2579 -0.641 1.0 N 0.721 0.245 0.457286136841 gnomAD-2.1.1 7.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
V/M 32838 Fn3-127 44 None 0.2579 -0.641 1.0 N 0.721 0.245 0.457286136841 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 32838 Fn3-127 44 None 0.2579 -0.641 1.0 N 0.721 0.245 0.457286136841 gnomAD-4.0.0 8.67578E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18665E-05 0 0
T/I 32939 Fn3-128 44 rs1559083229 0.1177 None 0.051 N 0.305 0.184 0.26169431596 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/I 32939 Fn3-128 44 rs1559083229 0.1177 None 0.051 N 0.305 0.184 0.26169431596 gnomAD-4.0.0 2.73686E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69847E-06 1.15931E-05 0
T/R 32939 Fn3-128 44 None 0.2279 None 0.934 N 0.365 0.306 0.471211772063 gnomAD-4.0.0 6.84215E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99489E-07 0 0
S/A 33040 Fn3-129 43 None 0.0593 None 0.061 N 0.156 0.072 0.126345400529 gnomAD-4.0.0 6.84212E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99486E-07 0 0
S/P 33040 Fn3-129 43 rs772469694 0.2105 -0.18 0.988 N 0.391 0.325 0.305410167561 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/P 33040 Fn3-129 43 rs772469694 0.2105 -0.18 0.988 N 0.391 0.325 0.305410167561 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/P 33040 Fn3-129 43 rs772469694 0.2105 -0.18 0.988 N 0.391 0.325 0.305410167561 gnomAD-4.0.0 3.71841E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23824E-06 0 1.60113E-05
S/T 33040 Fn3-129 43 rs772469694 0.0742 -0.349 0.134 N 0.157 0.082 0.139678290688 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/T 33040 Fn3-129 43 rs772469694 0.0742 -0.349 0.134 N 0.157 0.082 0.139678290688 gnomAD-4.0.0 6.84212E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99486E-07 0 0
A/G 33333 Fn3-130 44 rs746653975 0.2217 -1.165 1.0 N 0.607 0.363 0.287603790349 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
A/G 33333 Fn3-130 44 rs746653975 0.2217 -1.165 1.0 N 0.607 0.363 0.287603790349 gnomAD-4.0.0 6.84463E-07 None None None None N None 0 2.24034E-05 None 0 0 None 0 0 0 0 0
A/P 33333 Fn3-130 44 rs1171018948 0.5664 -0.275 1.0 N 0.733 0.501 0.341226946553 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
A/V 33333 Fn3-130 44 None 0.2254 None 1.0 N 0.671 0.379 0.297375071883 gnomAD-4.0.0 6.84463E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99625E-07 0 0
T/A 33731 Fn3-132 43 rs746383312 0.1218 -0.888 0.963 N 0.501 0.29 0.162503812791 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/A 33731 Fn3-132 43 rs746383312 0.1218 -0.888 0.963 N 0.501 0.29 0.162503812791 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.