Structural position:

  • Domain Type: Fn3
  • Aligned Position: 64
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/I 15703 Fn3-1 47 rs949814758 0.5353 -0.086 1.0 N 0.583 0.425 0.444807159249 gnomAD-2.1.1 8.07E-06 None None None None I None 0 0 None 0 5.62E-05 None 3.27E-05 None 0 0 0
T/I 15703 Fn3-1 47 rs949814758 0.5353 -0.086 1.0 N 0.583 0.425 0.444807159249 gnomAD-3.1.2 6.59E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
T/I 15703 Fn3-1 47 rs949814758 0.5353 -0.086 1.0 N 0.583 0.425 0.444807159249 gnomAD-4.0.0 9.30269E-06 None None None None I None 0 0 None 0 0 None 0 1.64636E-04 8.48094E-07 1.20799E-04 3.20554E-05
T/P 15703 Fn3-1 47 None 0.4681 None 1.0 N 0.581 0.542 0.392702134506 gnomAD-4.0.0 1.59362E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86259E-06 0 0
T/S 15703 Fn3-1 47 rs780903648 0.2157 -0.49 0.999 N 0.527 0.325 0.268211541103 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/S 15703 Fn3-1 47 rs780903648 0.2157 -0.49 0.999 N 0.527 0.325 0.268211541103 gnomAD-4.0.0 6.84645E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99897E-07 0 0
R/S 15804 Fn3-2 47 rs759143403 0.5093 -0.167 0.425 N 0.301 0.171 0.181679512989 gnomAD-2.1.1 9.67E-05 None None None None I None 0 0 None 0 0 None 7.84365E-04 None 0 0 0
R/S 15804 Fn3-2 47 rs759143403 0.5093 -0.167 0.425 N 0.301 0.171 0.181679512989 gnomAD-4.0.0 4.24444E-05 None None None None I None 0 0 None 0 0 None 0 0 0 6.95797E-04 3.31664E-05
N/D 15905 Fn3-3 47 None 0.1187 None 0.001 N 0.119 0.122 0.124217242631 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/I 16101 Fn3-4 47 None 0.337 None 0.987 D 0.501 0.362 0.41859458845 gnomAD-4.0.0 1.59478E-06 None None None None N None 0 0 None 0 0 None 1.88303E-05 0 0 0 0
T/S 16101 Fn3-4 47 rs1450802850 0.1514 -0.306 0.989 N 0.445 0.139 0.163833314356 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 16101 Fn3-4 47 rs1450802850 0.1514 -0.306 0.989 N 0.445 0.139 0.163833314356 gnomAD-4.0.0 1.59473E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43443E-05 0
V/G 16397 Fn3-6 47 rs761480322 0.1653 -1.221 0.497 N 0.505 0.265 0.663191565261 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
V/G 16397 Fn3-6 47 rs761480322 0.1653 -1.221 0.497 N 0.505 0.265 0.663191565261 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/G 16397 Fn3-6 47 rs761480322 0.1653 -1.221 0.497 N 0.505 0.265 0.663191565261 gnomAD-4.0.0 5.13209E-06 None None None None N None 0 0 None 0 0 None 0 0 9.5847E-06 0 0
V/L 16397 Fn3-6 47 None 0.1248 None 0.009 N 0.179 0.048 0.126345400529 gnomAD-4.0.0 3.18733E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86656E-05 0
V/M 16397 Fn3-6 47 rs397517595 0.1037 None 0.009 N 0.238 0.063 0.170165803431 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 16397 Fn3-6 47 rs397517595 0.1037 None 0.009 N 0.238 0.063 0.170165803431 gnomAD-4.0.0 6.58553E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47293E-05 0 0
E/D 16597 Fn3-8 47 None 0.0616 None None N 0.237 0.048 0.0986583533028 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/A 16697 Fn3-9 47 None 0.1898 None 0.974 N 0.509 0.197 0.195762928549 gnomAD-4.0.0 1.59394E-06 None None None None I None 5.67344E-05 0 None 0 0 None 0 0 0 0 0
G/C 16697 Fn3-9 47 rs1553698627 0.6209 -0.346 1.0 D 0.785 0.487 0.737189981757 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/C 16697 Fn3-9 47 rs1553698627 0.6209 -0.346 1.0 D 0.785 0.487 0.737189981757 gnomAD-4.0.0 2.05408E-06 None None None None I None 2.99294E-05 0 None 0 0 None 0 0 0 1.15988E-05 1.65859E-05
G/S 16697 Fn3-9 47 rs1553698627 0.1802 -0.338 1.0 N 0.575 0.354 0.226586394389 gnomAD-2.1.1 1.22E-05 None None None None I None 0 8.73E-05 None 0 0 None 0 None 0 0 0
G/S 16697 Fn3-9 47 rs1553698627 0.1802 -0.338 1.0 N 0.575 0.354 0.226586394389 gnomAD-4.0.0 6.84694E-07 None None None None I None 0 2.23974E-05 None 0 0 None 0 0 0 0 0
R/C 16797 Fn3-10 47 rs1015961035 0.7932 None 1.0 D 0.768 0.507 None gnomAD-4.0.0 6.16266E-06 None None None None I None 2.99258E-05 0 None 0 0 None 0 0 6.29914E-06 0 1.65837E-05
R/H 16797 Fn3-10 47 rs200835354 0.5352 -0.584 1.0 N 0.744 0.396 None gnomAD-2.1.1 1.07601E-04 None None None None I None 2.06919E-04 5.68E-05 None 0 0 None 0 None 4.40458E-04 8.64E-05 1.40964E-04
R/H 16797 Fn3-10 47 rs200835354 0.5352 -0.584 1.0 N 0.744 0.396 None gnomAD-3.1.2 1.31593E-04 None None None None I None 2.17202E-04 1.31079E-04 0 0 0 None 4.71342E-04 0 5.89E-05 0 0
R/H 16797 Fn3-10 47 rs200835354 0.5352 -0.584 1.0 N 0.744 0.396 None gnomAD-4.0.0 1.01712E-04 None None None None I None 2.00401E-04 6.6807E-05 None 0 2.24085E-05 None 4.69043E-04 3.29707E-04 9.15886E-05 0 6.41108E-05
R/S 17193 Fn3-13 47 rs759285989 0.2537 -0.009 0.012 N 0.365 0.093 0.0482279557977 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.56E-05 0
R/S 17193 Fn3-13 47 rs759285989 0.2537 -0.009 0.012 N 0.365 0.093 0.0482279557977 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 17193 Fn3-13 47 rs759285989 0.2537 -0.009 0.012 N 0.365 0.093 0.0482279557977 gnomAD-4.0.0 9.92025E-06 None None None None N None 2.67401E-05 0 None 0 0 None 0 3.29164E-04 7.63175E-06 1.0983E-05 3.20472E-05
E/G 17417 Fn3-14 49 rs1316644497 0.1551 -1.401 None N 0.209 0.132 0.238096912614 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/G 17417 Fn3-14 49 rs1316644497 0.1551 -1.401 None N 0.209 0.132 0.238096912614 gnomAD-4.0.0 1.59375E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
H/N 17515 Fn3-15 46 rs1576373600 0.4025 None 0.99 N 0.451 0.35 0.269558022972 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
H/N 17515 Fn3-15 46 rs1576373600 0.4025 None 0.99 N 0.451 0.35 0.269558022972 gnomAD-4.0.0 4.34181E-06 None None None None I None 0 0 None 0 0 None 0 0 0 7.69366E-05 0
H/P 17515 Fn3-15 46 None 0.8274 None 0.999 N 0.563 0.515 0.397838977388 gnomAD-4.0.0 6.84776E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99892E-07 0 0
H/R 17515 Fn3-15 46 rs1319404770 0.3818 -0.24 0.135 N 0.301 0.268 0.178374595973 gnomAD-4.0.0 4.79343E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29925E-06 0 0
H/Y 17515 Fn3-15 46 None 0.163 None 0.997 N 0.405 0.479 0.313210971179 gnomAD-4.0.0 2.05436E-06 None None None None I None 0 0 None 0 2.53575E-05 None 0 0 1.79978E-06 0 0
E/G 17615 Fn3-16 47 None 0.2167 None 0.961 N 0.435 0.442 0.415438038341 gnomAD-4.0.0 1.59276E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86131E-06 0 0
D/N 17908 Fn3-18 47 rs778472800 0.0714 -0.519 0.004 N 0.175 0.107 0.202949470691 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
E/K 18113 Fn3-19 49 None 0.2371 None 0.698 N 0.487 0.231 0.347438807231 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Y/F 18212 Fn3-20 47 rs772610346 0.1036 None 0.999 N 0.55 0.293 0.474643619859 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/E 18318 Fn3-21 47 rs951863461 0.1039 None 0.37 N 0.358 0.061 0.159798565429 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 18318 Fn3-21 47 rs951863461 0.1039 None 0.37 N 0.358 0.061 0.159798565429 gnomAD-4.0.0 2.5666E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79294E-06 0 0
D/Y 18318 Fn3-21 47 None 0.1803 None 1.0 N 0.615 0.462 0.686914373969 gnomAD-4.0.0 1.5942E-06 None None None None N None 0 0 None 0 2.7908E-05 None 0 0 0 0 0
A/V 18630 Fn3-23 52 None 0.1124 None 0.669 N 0.285 0.199 0.366277470483 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/A 18831 Fn3-24 48 None 0.0977 None 0.64 N 0.403 0.122 0.176091768786 gnomAD-4.0.0 6.86315E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00763E-07 0 0
T/S 18831 Fn3-24 48 rs778893070 0.1258 -0.498 0.251 N 0.219 0.12 0.141422826196 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9E-06 0
T/S 18831 Fn3-24 48 rs778893070 0.1258 -0.498 0.251 N 0.219 0.12 0.141422826196 gnomAD-4.0.0 6.86315E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00763E-07 0 0
R/G 18930 Fn3-25 47 rs727503595 0.7991 None 1.0 N 0.587 0.312 0.284150004643 gnomAD-4.0.0 6.84471E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99651E-06 0 0
R/K 18930 Fn3-25 47 rs746833235 0.2912 0.097 0.997 N 0.591 0.279 0.350964488264 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
E/A 19034 Fn3-26 47 None 0.0851 None 0.999 N 0.583 0.288 0.429320821379 gnomAD-4.0.0 2.06382E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.58466E-05 0
E/K 19034 Fn3-26 47 rs1021198349 0.1062 None 0.999 N 0.632 0.329 0.382925413656 gnomAD-4.0.0 1.61298E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87417E-06 0 0
V/F 19526 Fn3-29 48 rs377682563 0.1572 -0.759 0.144 N 0.283 0.098 0.273503213844 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
V/F 19526 Fn3-29 48 rs377682563 0.1572 -0.759 0.144 N 0.283 0.098 0.273503213844 gnomAD-4.0.0 6.84375E-07 None None None None I None 0 0 None 0 2.52666E-05 None 0 0 0 0 0
V/I 19526 Fn3-29 48 rs377682563 0.0711 -0.189 0.001 N 0.13 0.037 None gnomAD-2.1.1 1.43085E-04 None None None None I None 1.65344E-04 0 None 0 0 None 6.54E-05 None 0 2.58483E-04 1.40528E-04
V/I 19526 Fn3-29 48 rs377682563 0.0711 -0.189 0.001 N 0.13 0.037 None gnomAD-3.1.2 1.90779E-04 None None None None I None 7.25E-05 6.56E-05 0 0 0 None 0 0 3.53045E-04 0 4.78927E-04
V/I 19526 Fn3-29 48 rs377682563 0.0711 -0.189 0.001 N 0.13 0.037 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
V/I 19526 Fn3-29 48 rs377682563 0.0711 -0.189 0.001 N 0.13 0.037 None gnomAD-4.0.0 3.30376E-04 None None None None I None 8.00149E-05 3.33589E-05 None 0 0 None 0 1.65125E-04 4.22179E-04 7.68707E-05 3.04185E-04
R/L 19624 Fn3-30 46 None 0.4463 None 0.023 N 0.399 0.154 0.344251166708 gnomAD-4.0.0 6.84365E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65689E-05
R/P 19624 Fn3-30 46 None 0.8947 None 0.705 N 0.423 0.273 0.358744678677 gnomAD-4.0.0 6.84365E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65689E-05
R/Q 19624 Fn3-30 46 rs1224706842 0.2431 0.035 0.566 N 0.448 0.176 0.178374595973 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/Q 19624 Fn3-30 46 rs1224706842 0.2431 0.035 0.566 N 0.448 0.176 0.178374595973 gnomAD-4.0.0 6.15929E-06 None None None None I None 2.98989E-05 2.23754E-05 None 0 2.52385E-05 None 0 0 3.59847E-06 0 3.31378E-05
E/K 19726 Fn3-31 47 rs1356102019 0.1511 None 0.834 N 0.611 0.259 0.27479166964 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 19726 Fn3-31 47 rs1356102019 0.1511 None 0.834 N 0.611 0.259 0.27479166964 gnomAD-4.0.0 3.09903E-06 None None None None N None 0 0 None 0 0 None 0 0 4.2387E-06 0 0
E/Q 19726 Fn3-31 47 None 0.139 None 0.946 N 0.599 0.298 0.318252033908 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99582E-07 0 0
Q/H 19923 Fn3-32 47 rs2050348587 0.1427 None 0.484 N 0.308 0.101 0.268660756437 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
Q/H 19923 Fn3-32 47 rs2050348587 0.1427 None 0.484 N 0.308 0.101 0.268660756437 gnomAD-4.0.0 6.57947E-06 None None None None I None 0 6.55566E-05 None 0 0 None 0 0 0 0 0
D/E 20023 Fn3-33 47 rs2050254249 0.1046 None 0.014 N 0.334 0.077 0.210429274316 gnomAD-4.0.0 1.59211E-06 None None None None N None 0 0 None 0 2.7804E-05 None 0 0 0 0 0
D/V 20023 Fn3-33 47 None 0.1723 None 0.942 N 0.715 0.441 0.391930172978 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/A 20218 Fn3-34 48 rs766630391 0.0758 -0.275 0.489 N 0.401 0.095 0.19670166235 gnomAD-2.1.1 2.42E-05 None None None None I None 0 0 None 0 0 None 0 None 0 5.36E-05 0
T/A 20218 Fn3-34 48 rs766630391 0.0758 -0.275 0.489 N 0.401 0.095 0.19670166235 gnomAD-4.0.0 8.89675E-06 None None None None I None 0 0 None 0 0 None 0 0 1.16949E-05 0 0
T/K 20218 Fn3-34 48 rs375155937 0.1848 None 0.954 N 0.377 0.347 None gnomAD-4.0.0 1.36875E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79923E-06 0 0
T/M 20218 Fn3-34 48 rs375155937 0.0996 -0.061 1.0 N 0.437 0.328 None gnomAD-2.1.1 2.51E-05 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 3.92E-05 0
T/M 20218 Fn3-34 48 rs375155937 0.0996 -0.061 1.0 N 0.437 0.328 None gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
T/M 20218 Fn3-34 48 rs375155937 0.0996 -0.061 1.0 N 0.437 0.328 None gnomAD-4.0.0 9.29821E-06 None None None None I None 2.67151E-05 0 None 0 0 None 0 0 1.01732E-05 0 1.60154E-05
K/T 20316 Fn3-35 46 rs554673070 0.4535 0.03 1.0 N 0.59 0.46 0.516604699598 gnomAD-2.1.1 7.19E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
K/T 20316 Fn3-35 46 rs554673070 0.4535 0.03 1.0 N 0.59 0.46 0.516604699598 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
K/T 20316 Fn3-35 46 rs554673070 0.4535 0.03 1.0 N 0.59 0.46 0.516604699598 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
K/T 20316 Fn3-35 46 rs554673070 0.4535 0.03 1.0 N 0.59 0.46 0.516604699598 gnomAD-4.0.0 1.97106E-05 None None None None N None 7.21605E-05 0 None 0 0 None 0 0 0 0 0
Q/K 20417 Fn3-36 47 None 0.0901 None 0.001 N 0.131 0.12 0.0920862733494 gnomAD-4.0.0 1.59263E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86069E-06 0 0
G/A 20615 Fn3-37 47 rs780002348 0.203 -0.049 0.948 N 0.477 0.173 0.28722502521 gnomAD-2.1.1 2.81E-05 None None None None N None 0 0 None 0 5.61E-05 None 3.27E-05 None 0 2.66E-05 3.31236E-04
G/A 20615 Fn3-37 47 rs780002348 0.203 -0.049 0.948 N 0.477 0.173 0.28722502521 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 1.94099E-04 None 0 0 2.94E-05 0 0
G/A 20615 Fn3-37 47 rs780002348 0.203 -0.049 0.948 N 0.477 0.173 0.28722502521 gnomAD-4.0.0 1.41007E-05 None None None None N None 0 0 None 0 2.43309E-05 None 0 6.72646E-04 1.19706E-05 1.34027E-05 2.84576E-05
G/S 20615 Fn3-37 47 rs746925906 0.1969 -0.22 0.956 N 0.418 0.227 0.297375071883 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/S 20615 Fn3-37 47 rs746925906 0.1969 -0.22 0.956 N 0.418 0.227 0.297375071883 gnomAD-4.0.0 1.59213E-06 None None None None N None 0 2.28822E-05 None 0 0 None 0 0 0 0 0
G/V 20615 Fn3-37 47 None 0.3709 None 0.956 N 0.564 0.269 0.514472708086 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43308E-05 0
D/E 20714 Fn3-38 47 None 0.0707 None None N 0.117 0.07 0.166414681773 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/Q 21009 Fn3-40 47 rs72646851 0.1808 0.156 1.0 N 0.689 0.299 None gnomAD-2.1.1 2.20094E-03 None None None None I None 2.39828E-02 6.79656E-04 None 0 0 None 0 None 0 4.69E-05 8.43882E-04
R/Q 21009 Fn3-40 47 rs72646851 0.1808 0.156 1.0 N 0.689 0.299 None gnomAD-3.1.2 6.53947E-03 None None None None I None 2.2679E-02 2.68994E-03 0 0 0 None 0 0 1.17682E-04 0 2.87356E-03
R/Q 21009 Fn3-40 47 rs72646851 0.1808 0.156 1.0 N 0.689 0.299 None 1000 genomes 4.79233E-03 None None None None I None 1.82E-02 0 None None 0 0 None None None 0 None
R/Q 21009 Fn3-40 47 rs72646851 0.1808 0.156 1.0 N 0.689 0.299 None gnomAD-4.0.0 1.16664E-03 None None None None I None 2.23301E-02 1.40093E-03 None 0 0 None 0 1.65235E-04 4.49357E-05 0 1.12072E-03
G/R 21115 Fn3-41 52 None 0.4198 None 1.0 N 0.779 0.39 0.523650220922 gnomAD-4.0.0 1.59294E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
G/S 21115 Fn3-41 52 rs1559556478 0.16 None 1.0 N 0.598 0.378 0.296679040009 gnomAD-4.0.0 4.77882E-06 None None None None N None 0 0 None 0 8.35189E-05 None 0 0 0 0 0
R/C 21414 Fn3-43 49 rs373478378 0.2111 -0.093 0.996 N 0.231 0.341 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
R/C 21414 Fn3-43 49 rs373478378 0.2111 -0.093 0.996 N 0.231 0.341 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/C 21414 Fn3-43 49 rs373478378 0.2111 -0.093 0.996 N 0.231 0.341 None gnomAD-4.0.0 1.85986E-06 None None None None N None 1.33608E-05 0 None 0 0 None 0 1.64636E-04 8.47887E-07 0 0
R/H 21414 Fn3-43 49 rs727504690 0.109 -0.597 0.009 N 0.207 0.135 0.178374595973 gnomAD-2.1.1 2.41E-05 None None None None N None 6.46E-05 2.9E-05 None 0 5.59E-05 None 9.8E-05 None 0 0 0
R/H 21414 Fn3-43 49 rs727504690 0.109 -0.597 0.009 N 0.207 0.135 0.178374595973 gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 4.78927E-04
R/H 21414 Fn3-43 49 rs727504690 0.109 -0.597 0.009 N 0.207 0.135 0.178374595973 gnomAD-4.0.0 1.11591E-05 None None None None N None 2.67258E-05 1.668E-05 None 0 2.23374E-05 None 0 0 2.54366E-06 1.0981E-04 1.6019E-05
D/H 21606 Fn3-44 48 rs751046367 0.3828 -0.072 0.948 N 0.637 0.344 0.235038932564 gnomAD-2.1.1 7.65E-05 None None None None I None 0 0 None 0 0 None 9.8E-05 None 0 1.42592E-04 0
D/H 21606 Fn3-44 48 rs751046367 0.3828 -0.072 0.948 N 0.637 0.344 0.235038932564 gnomAD-3.1.2 3.29E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 2.07297E-04 0
D/H 21606 Fn3-44 48 rs751046367 0.3828 -0.072 0.948 N 0.637 0.344 0.235038932564 gnomAD-4.0.0 2.60341E-05 None None None None I None 1.33561E-05 0 None 0 0 None 0 8.22639E-04 2.28904E-05 5.49064E-05 6.40697E-05
L/Q 21705 Fn3-45 47 rs2154179812 0.5754 None 1.0 N 0.699 0.477 0.808029720589 gnomAD-4.0.0 1.50565E-05 None None None None I None 0 0 None 0 0 None 0 0 1.9792E-05 0 0
K/R 21803 Fn3-46 47 None 0.0869 None 0.41 N 0.535 0.126 0.222439326576 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/T 21803 Fn3-46 47 rs2048309985 0.1644 None 0.83 N 0.507 0.251 0.352476196916 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/T 21803 Fn3-46 47 rs2048309985 0.1644 None 0.83 N 0.507 0.251 0.352476196916 gnomAD-4.0.0 6.57549E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
N/K 22002 Fn3-47 47 rs756154183 0.8705 0.12 0.904 N 0.279 0.164 0.193865811164 gnomAD-2.1.1 2.02E-05 None None None None N None 0 1.45307E-04 None 0 0 None 0 None 0 0 0
N/K 22002 Fn3-47 47 rs756154183 0.8705 0.12 0.904 N 0.279 0.164 0.193865811164 gnomAD-4.0.0 7.96541E-06 None None None None N None 0 1.14432E-04 None 0 0 None 0 0 0 0 0
N/S 22002 Fn3-47 47 rs2047996309 0.1165 None 0.698 N 0.373 0.2 0.141422826196 gnomAD-4.0.0 3.42275E-06 None None None None N None 2.99204E-05 0 None 0 0 None 0 0 3.59901E-06 0 0
N/Y 22101 Fn3-48 47 None 0.1774 None 0.954 N 0.304 0.33 0.519514513453 gnomAD-4.0.0 2.05314E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69899E-06 0 0
N/K 22202 Fn3-49 47 rs1224096976 0.2446 0.353 0.055 N 0.287 0.082 0.141422826196 gnomAD-4.0.0 3.18729E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72403E-06 0 0
S/P 22400 Fn3-50 47 rs1575883693 0.6938 None 0.984 N 0.304 0.372 0.32306181527 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 0 None 0 2.77469E-05 None 0 0 0 0 0
K/R 22496 Fn3-51 46 rs397517669 0.0853 -0.205 0.955 N 0.497 0.206 0.231873229951 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.57E-05 0
K/R 22496 Fn3-51 46 rs397517669 0.0853 -0.205 0.955 N 0.497 0.206 0.231873229951 gnomAD-4.0.0 1.43722E-05 None None None None N None 0 0 None 0 0 None 0 0 1.79929E-05 0 1.65739E-05
S/F 22887 Fn3-54 47 rs2046762704 0.1737 None 0.295 N 0.363 0.138 0.404592120364 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/F 22887 Fn3-54 47 rs2046762704 0.1737 None 0.295 N 0.363 0.138 0.404592120364 gnomAD-4.0.0 6.57903E-06 None None None None N None 2.41441E-05 0 None 0 0 None 0 0 0 0 0
S/T 22887 Fn3-54 47 None 0.0673 None None N 0.139 0.043 0.0138822411134 gnomAD-4.0.0 2.05319E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69886E-06 0 0
R/Q 23185 Fn3-56 47 rs201448988 0.218 0.012 1.0 N 0.697 0.332 None gnomAD-2.1.1 5.63E-05 None None None None I None 6.46E-05 0 None 0 0 None 2.28773E-04 None 0 5.33E-05 0
R/Q 23185 Fn3-56 47 rs201448988 0.218 0.012 1.0 N 0.697 0.332 None gnomAD-3.1.2 2.63E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 2.07297E-04 0
R/Q 23185 Fn3-56 47 rs201448988 0.218 0.012 1.0 N 0.697 0.332 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
R/Q 23185 Fn3-56 47 rs201448988 0.218 0.012 1.0 N 0.697 0.332 None gnomAD-4.0.0 7.80904E-05 None None None None I None 4.00021E-05 0 None 0 0 None 0 0 8.64694E-05 1.86674E-04 6.4041E-05
A/D 23286 Fn3-57 47 rs1465961266 0.0995 None None N 0.179 0.077 0.193865811164 gnomAD-4.0.0 6.87762E-06 None None None None N None 0 0 None 0 0 None 0 0 8.117E-06 0 1.66689E-05
A/T 23286 Fn3-57 47 rs1710048909 0.0601 None None N 0.125 0.071 0.0551355673512 gnomAD-4.0.0 4.83852E-06 None None None None N None 0 0 None 0 0 None 0 0 8.65841E-06 0 0
A/V 23286 Fn3-57 47 rs1465961266 0.0778 -0.147 0.012 N 0.287 0.046 0.176091768786 gnomAD-2.1.1 4.16E-06 None None None None N None 0 2.98E-05 None 0 0 None 0 None 0 0 0
A/V 23286 Fn3-57 47 rs1465961266 0.0778 -0.147 0.012 N 0.287 0.046 0.176091768786 gnomAD-4.0.0 6.87762E-07 None None None None N None 0 2.29316E-05 None 0 0 None 0 0 0 0 0
Q/H 23578 Fn3-59 47 rs1342674248 0.1546 -0.281 0.009 N 0.305 0.069 0.166414681773 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
Q/H 23578 Fn3-59 47 rs1342674248 0.1546 -0.281 0.009 N 0.305 0.069 0.166414681773 gnomAD-4.0.0 1.59176E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8591E-06 0 0
Q/R 23578 Fn3-59 47 rs1332842062 0.0871 0.471 0.379 N 0.309 0.196 0.191931220699 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/R 23578 Fn3-59 47 rs1332842062 0.0871 0.471 0.379 N 0.309 0.196 0.191931220699 gnomAD-4.0.0 1.59175E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
T/I 23773 Fn3-60 48 rs775492043 0.1401 -0.104 0.949 N 0.423 0.328 0.350964488264 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 23773 Fn3-60 48 rs775492043 0.1401 -0.104 0.949 N 0.423 0.328 0.350964488264 gnomAD-4.0.0 1.24027E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69596E-06 0 0
T/N 23773 Fn3-60 48 None 0.1003 None 0.565 N 0.399 0.24 0.270889551736 gnomAD-4.0.0 6.84655E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9985E-07 0 0
T/S 23773 Fn3-60 48 rs775492043 0.0855 -0.29 0.014 N 0.231 0.058 0.171388866994 gnomAD-2.1.1 8.1E-06 None None None None I None 0 0 None 0 0 None 6.56E-05 None 0 0 0
T/S 23773 Fn3-60 48 rs775492043 0.0855 -0.29 0.014 N 0.231 0.058 0.171388866994 gnomAD-4.0.0 4.79258E-06 None None None None I None 0 0 None 0 0 None 0 0 0 8.1248E-05 0
R/Q 23970 Fn3-62 47 rs727503563 0.2584 -0.074 1.0 N 0.668 0.376 0.284150004643 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
R/Q 23970 Fn3-62 47 rs727503563 0.2584 -0.074 1.0 N 0.668 0.376 0.284150004643 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/Q 23970 Fn3-62 47 rs727503563 0.2584 -0.074 1.0 N 0.668 0.376 0.284150004643 gnomAD-4.0.0 7.43857E-06 None None None None N None 2.6708E-05 0 None 0 0 None 0 0 6.78221E-06 2.19621E-05 0
R/W 23970 Fn3-62 47 rs748041610 0.4775 -0.385 1.0 N 0.777 0.529 0.367042808489 gnomAD-2.1.1 2.87E-05 None None None None N None 0 0 None 0 1.55167E-04 None 1.30762E-04 None 0 7.85E-06 0
R/W 23970 Fn3-62 47 rs748041610 0.4775 -0.385 1.0 N 0.777 0.529 0.367042808489 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 1.93648E-04 None 0 0 1.47E-05 4.14079E-04 0
R/W 23970 Fn3-62 47 rs748041610 0.4775 -0.385 1.0 N 0.777 0.529 0.367042808489 gnomAD-4.0.0 2.10762E-05 None None None None N None 0 0 None 0 6.70601E-05 None 0 0 1.10214E-05 1.64701E-04 4.80492E-05
A/T 24169 Fn3-63 48 None 0.14 None 0.067 N 0.339 0.127 0.392395365052 gnomAD-4.0.0 1.94048E-06 None None None None I None 0 0 None 0 0 None 0 0 3.36279E-06 0 0
R/C 24268 Fn3-64 47 rs370474301 0.4658 -0.418 1.0 D 0.738 0.51 None gnomAD-2.1.1 1.39115E-04 None None None None N None 4.24E-05 3.71E-05 None 2.68908E-03 2.76213E-04 None 0 None 0 7.31E-05 1.75131E-04
R/C 24268 Fn3-64 47 rs370474301 0.4658 -0.418 1.0 D 0.738 0.51 None gnomAD-3.1.2 9.87E-05 None None None None N None 4.83E-05 0 0 2.30415E-03 1.93798E-04 None 0 0 5.89E-05 0 0
R/C 24268 Fn3-64 47 rs370474301 0.4658 -0.418 1.0 D 0.738 0.51 None gnomAD-4.0.0 7.66042E-05 None None None None N None 2.74055E-05 1.95442E-05 None 2.13261E-03 2.2607E-04 None 0 0 3.64775E-05 3.7772E-05 1.00204E-04
R/H 24268 Fn3-64 47 rs140018785 0.2176 -1.061 1.0 N 0.715 0.415 None gnomAD-2.1.1 3.52233E-04 None None None None N None 1.34156E-04 0 None 0 4.02838E-03 None 0 None 0 1.06E-05 0
R/H 24268 Fn3-64 47 rs140018785 0.2176 -1.061 1.0 N 0.715 0.415 None gnomAD-3.1.2 7.23E-05 None None None None N None 4.83E-05 0 0 0 1.74149E-03 None 0 0 0 0 0
R/H 24268 Fn3-64 47 rs140018785 0.2176 -1.061 1.0 N 0.715 0.415 None 1000 genomes 9.98403E-04 None None None None N None 2.3E-03 0 None None 2E-03 0 None None None 0 None
R/H 24268 Fn3-64 47 rs140018785 0.2176 -1.061 1.0 N 0.715 0.415 None gnomAD-4.0.0 2.19458E-04 None None None None N None 4.1061E-05 0 None 0 7.20643E-03 None 0 0 9.55246E-06 1.25856E-05 1.16815E-04
A/T 24565 Fn3-66 47 rs772524912 0.469 -0.326 1.0 N 0.565 0.309 0.41219620536 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/T 24565 Fn3-66 47 rs772524912 0.469 -0.326 1.0 N 0.565 0.309 0.41219620536 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 24565 Fn3-66 47 rs772524912 0.469 -0.326 1.0 N 0.565 0.309 0.41219620536 gnomAD-4.0.0 2.56627E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79619E-06 0 0
A/V 24565 Fn3-66 47 rs865844614 0.6468 None 1.0 N 0.531 0.35 0.507628581994 gnomAD-4.0.0 3.42362E-06 None None None None N None 0 0 None 0 0 None 0 6.94686E-04 9.00131E-07 0 0
K/N 24662 Fn3-67 47 None 0.5072 None 0.882 N 0.627 0.17 0.187945064343 gnomAD-4.0.0 1.59218E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85936E-06 0 0
K/R 24662 Fn3-67 47 None 0.0788 None 0.003 N 0.353 0.146 0.241078983079 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 24855 Fn3-68 48 rs759432194 0.1356 -0.06 None N 0.218 0.097 0.219573609325 gnomAD-2.1.1 1.11296E-04 None None None None N None 0 0 None 0 0 None 0 None 2.80134E-04 1.81259E-04 1.41084E-04
T/I 24855 Fn3-68 48 rs759432194 0.1356 -0.06 None N 0.218 0.097 0.219573609325 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/I 24855 Fn3-68 48 rs759432194 0.1356 -0.06 None N 0.218 0.097 0.219573609325 gnomAD-4.0.0 4.2775E-05 None None None None N None 0 0 None 0 0 None 1.40757E-04 0 5.08659E-05 0 0
T/S 24855 Fn3-68 48 None 0.0869 None 0.001 N 0.139 0.028 0.0716867268079 gnomAD-4.0.0 1.59247E-06 None None None None N None 0 0 None 0 2.7852E-05 None 0 0 0 0 0
L/F 24954 Fn3-69 47 rs202191466 0.5238 -0.557 1.0 N 0.585 0.32 0.586602809486 gnomAD-2.1.1 1.12726E-04 None None None None I None 0 6.95612E-04 None 0 0 None 3.27E-05 None 0 1.78E-05 1.65893E-04
L/F 24954 Fn3-69 47 rs202191466 0.5238 -0.557 1.0 N 0.585 0.32 0.586602809486 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
L/F 24954 Fn3-69 47 rs202191466 0.5238 -0.557 1.0 N 0.585 0.32 0.586602809486 gnomAD-4.0.0 2.47937E-05 None None None None I None 0 4.5039E-04 None 0 0 None 0 0 8.47719E-06 1.09798E-05 3.20318E-05
L/P 24954 Fn3-69 47 None 0.9617 None 1.0 N 0.735 0.569 0.810833939436 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 25052 Fn3-70 47 rs1303893206 0.5244 -0.114 1.0 N 0.591 0.414 0.612105117874 gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 8E-05 7.83E-06 0
R/C 25052 Fn3-70 47 rs1303893206 0.5244 -0.114 1.0 N 0.591 0.414 0.612105117874 gnomAD-4.0.0 8.21181E-06 None None None None I None 0 0 None 0 0 None 7.49232E-05 0 6.29726E-06 1.15945E-05 0
R/H 25052 Fn3-70 47 rs542720402 0.2665 -0.692 0.999 D 0.458 0.366 0.321108458156 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 1.11359E-04 None 3.27E-05 None 0 8.9E-06 0
R/H 25052 Fn3-70 47 rs542720402 0.2665 -0.692 0.999 D 0.458 0.366 0.321108458156 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 3.87898E-04 None 0 0 1.47E-05 0 0
R/H 25052 Fn3-70 47 rs542720402 0.2665 -0.692 0.999 D 0.458 0.366 0.321108458156 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
R/H 25052 Fn3-70 47 rs542720402 0.2665 -0.692 0.999 D 0.458 0.366 0.321108458156 gnomAD-4.0.0 6.19769E-06 None None None None I None 0 0 None 0 6.69135E-05 None 0 0 3.39099E-06 3.29388E-05 0
V/A 25251 Fn3-71 48 rs765677670 0.2881 -0.672 0.999 N 0.503 0.321 0.607460342511 gnomAD-2.1.1 7.18E-06 None None None None I None 0 0 None 0 1.03563E-04 None 0 None 0 0 0
V/A 25251 Fn3-71 48 rs765677670 0.2881 -0.672 0.999 N 0.503 0.321 0.607460342511 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 1.93723E-04 None 0 0 0 4.13736E-04 0
V/A 25251 Fn3-71 48 rs765677670 0.2881 -0.672 0.999 N 0.503 0.321 0.607460342511 gnomAD-4.0.0 4.06027E-06 None None None None I None 0 0 None 0 1.1374E-04 None 0 0 0 1.40885E-04 0
E/G 25451 Fn3-73 47 None 0.1783 None 0.822 N 0.483 0.331 0.371344866733 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 25647 Fn3-74 47 None 0.1558 None 0.001 N 0.111 0.095 0.119812018005 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 25744 Fn3-75 47 rs1482499927 0.2794 0.367 0.325 N 0.218 0.098 0.0884992946249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
K/N 25744 Fn3-75 47 rs1482499927 0.2794 0.367 0.325 N 0.218 0.098 0.0884992946249 gnomAD-4.0.0 6.84423E-07 None None None None N None 0 0 None 0 2.52067E-05 None 0 0 0 0 0
V/A 25937 Fn3-76 48 None 0.1053 None 0.024 N 0.235 0.065 0.44143026662 gnomAD-4.0.0 1.59202E-06 None None None None N None 0 0 None 0 2.77886E-05 None 0 0 0 0 0
V/I 25937 Fn3-76 48 None 0.0684 None None N 0.164 0.082 0.425028116352 gnomAD-4.0.0 3.18408E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85943E-06 0 3.02608E-05
L/F 26036 Fn3-77 47 rs904868866 0.5189 -0.636 0.967 N 0.468 0.248 0.454798141022 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
L/F 26036 Fn3-77 47 rs904868866 0.5189 -0.636 0.967 N 0.468 0.248 0.454798141022 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 26036 Fn3-77 47 rs904868866 0.5189 -0.636 0.967 N 0.468 0.248 0.454798141022 gnomAD-4.0.0 2.05312E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6988E-06 0 0
L/S 26036 Fn3-77 47 None 0.9018 None 0.967 N 0.549 0.452 0.768949010136 gnomAD-4.0.0 1.59218E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
R/C 26134 Fn3-78 47 rs753708513 0.7325 -0.102 1.0 N 0.547 0.361 0.597594485103 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/C 26134 Fn3-78 47 rs753708513 0.7325 -0.102 1.0 N 0.547 0.361 0.597594485103 gnomAD-4.0.0 9.56813E-06 None None None None N None 0 0 None 0 0 None 0 0 1.43325E-05 0 3.02975E-05
R/H 26134 Fn3-78 47 rs377668457 0.4362 -1.076 1.0 N 0.383 0.297 None gnomAD-2.1.1 2.87E-05 None None None None N None 0 0 None 0 5.15E-05 None 6.54E-05 None 0 3.93E-05 0
R/H 26134 Fn3-78 47 rs377668457 0.4362 -1.076 1.0 N 0.383 0.297 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 26134 Fn3-78 47 rs377668457 0.4362 -1.076 1.0 N 0.383 0.297 None gnomAD-4.0.0 7.93874E-05 None None None None N None 0 1.66856E-05 None 0 4.46648E-05 None 0 0 1.00103E-04 4.39319E-05 4.80661E-05
A/D 26333 Fn3-79 48 None 0.958 None 0.638 N 0.542 0.347 0.506673610527 gnomAD-4.0.0 1.36862E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31895E-05 0
A/S 26333 Fn3-79 48 rs1221437302 0.1717 -0.42 0.201 N 0.387 0.106 0.146414634003 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
A/S 26333 Fn3-79 48 rs1221437302 0.1717 -0.42 0.201 N 0.387 0.106 0.146414634003 gnomAD-4.0.0 3.1836E-06 None None None None I None 0 0 None 0 5.54939E-05 None 0 0 0 0 0
A/T 26333 Fn3-79 48 None 0.1664 None 0.002 N 0.263 0.087 0.171388866994 gnomAD-4.0.0 3.1836E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71883E-06 0 0
A/V 26333 Fn3-79 48 None 0.2319 None 0.002 N 0.277 0.234 0.311691414656 gnomAD-4.0.0 6.84309E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
R/Q 26432 Fn3-80 47 rs770752765 0.4611 -0.024 1.0 N 0.657 0.35 0.252681307341 gnomAD-2.1.1 3.23E-05 None None None None I None 0 0 None 0 0 None 0 None 0 7.14E-05 0
R/Q 26432 Fn3-80 47 rs770752765 0.4611 -0.024 1.0 N 0.657 0.35 0.252681307341 gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 2.06954E-04 0
R/Q 26432 Fn3-80 47 rs770752765 0.4611 -0.024 1.0 N 0.657 0.35 0.252681307341 gnomAD-4.0.0 1.54964E-05 None None None None I None 1.33558E-05 0 None 0 0 None 0 1.6442E-04 1.86493E-05 1.09786E-05 0
E/K 26533 Fn3-81 47 None 0.1298 None 0.958 N 0.577 0.31 0.308278614506 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 26729 Fn3-82 47 rs1252013447 0.9096 None 0.998 N 0.385 0.352 0.392702134506 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/P 26729 Fn3-82 47 rs1252013447 0.9096 None 0.998 N 0.385 0.352 0.392702134506 gnomAD-4.0.0 1.85928E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54307E-06 0 0
A/V 26729 Fn3-82 47 rs747650124 0.3706 -0.038 0.518 N 0.207 0.115 0.361558571881 gnomAD-2.1.1 1.61E-05 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 1.78E-05 0
A/V 26729 Fn3-82 47 rs747650124 0.3706 -0.038 0.518 N 0.207 0.115 0.361558571881 gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 26729 Fn3-82 47 rs747650124 0.3706 -0.038 0.518 N 0.207 0.115 0.361558571881 gnomAD-4.0.0 1.79742E-05 None None None None N None 6.67824E-05 3.33556E-05 None 0 0 None 0 0 1.61065E-05 0 4.80446E-05
K/N 26826 Fn3-83 47 rs1318267898 0.2418 0.426 0.006 N 0.207 0.072 0.110078149338 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/N 26826 Fn3-83 47 rs1318267898 0.2418 0.426 0.006 N 0.207 0.072 0.110078149338 gnomAD-4.0.0 5.47424E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19656E-06 0 0
T/S 27019 Fn3-84 48 rs531674020 0.0842 -0.523 0.027 N 0.276 0.085 0.107399877778 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/S 27019 Fn3-84 48 rs531674020 0.0842 -0.523 0.027 N 0.276 0.085 0.107399877778 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
T/S 27019 Fn3-84 48 rs531674020 0.0842 -0.523 0.027 N 0.276 0.085 0.107399877778 gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8591E-06 0 0
L/S 27118 Fn3-85 47 None 0.8616 None 1.0 N 0.671 0.49 0.763842213962 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/V 27118 Fn3-85 47 rs1293763784 0.2799 -0.158 0.999 N 0.535 0.191 0.490839437361 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 5.74E-05 None 0 None 0 0 0
L/V 27118 Fn3-85 47 rs1293763784 0.2799 -0.158 0.999 N 0.535 0.191 0.490839437361 gnomAD-4.0.0 1.59518E-06 None None None None I None 0 0 None 0 2.78831E-05 None 0 0 0 0 0
R/C 27216 Fn3-86 47 rs756815015 0.6315 0.02 1.0 N 0.759 0.492 0.664980478371 gnomAD-2.1.1 1.09E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.4E-05 0
R/C 27216 Fn3-86 47 rs756815015 0.6315 0.02 1.0 N 0.759 0.492 0.664980478371 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 4.78927E-04
R/C 27216 Fn3-86 47 rs756815015 0.6315 0.02 1.0 N 0.759 0.492 0.664980478371 gnomAD-4.0.0 1.11676E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44213E-05 0 1.60287E-05
R/H 27216 Fn3-86 47 rs371910831 0.3467 -0.552 1.0 N 0.735 0.403 None gnomAD-2.1.1 3.27E-05 None None None None N None 4.18E-05 2.87E-05 None 0 0 None 6.6E-05 None 0 3.2E-05 1.42857E-04
R/H 27216 Fn3-86 47 rs371910831 0.3467 -0.552 1.0 N 0.735 0.403 None gnomAD-3.1.2 4.6E-05 None None None None N None 2.41E-05 0 0 2.88184E-04 0 None 0 0 5.88E-05 0 4.78469E-04
R/H 27216 Fn3-86 47 rs371910831 0.3467 -0.552 1.0 N 0.735 0.403 None gnomAD-4.0.0 2.544E-05 None None None None N None 1.33526E-05 3.35132E-05 None 3.38226E-05 2.23954E-05 None 0 0 2.46026E-05 5.50176E-05 3.20646E-05
S/F 27416 Fn3-87 48 None 0.3649 None 0.994 N 0.608 0.443 0.515092168024 gnomAD-4.0.0 1.36846E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79901E-06 0 0
R/T 27515 Fn3-88 47 rs757660615 0.7816 -0.094 1.0 N 0.657 0.426 0.396044805602 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 1.78E-05 0
R/T 27515 Fn3-88 47 rs757660615 0.7816 -0.094 1.0 N 0.657 0.426 0.396044805602 gnomAD-4.0.0 7.95651E-06 None None None None I None 0 0 None 0 2.77423E-05 None 0 0 1.14337E-05 0 0
A/D 27812 Fn3-90 47 None 0.9522 None 0.941 N 0.594 0.355 0.552451585512 gnomAD-4.0.0 6.92527E-07 None None None None N None 0 0 None 0 0 None 0 0 9.05343E-07 0 0
A/S 27812 Fn3-90 47 rs727504186 0.1583 -0.353 0.253 N 0.43 0.153 0.301789629655 gnomAD-2.1.1 1.71E-05 None None None None N None 0 3.17E-05 None 0 0 None 3.77E-05 None 0 1.85E-05 0
A/S 27812 Fn3-90 47 rs727504186 0.1583 -0.353 0.253 N 0.43 0.153 0.301789629655 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
A/S 27812 Fn3-90 47 rs727504186 0.1583 -0.353 0.253 N 0.43 0.153 0.301789629655 gnomAD-4.0.0 6.89373E-06 None None None None N None 0 7.03878E-05 None 0 0 None 0 0 3.41177E-06 1.1449E-05 3.24739E-05
A/V 27812 Fn3-90 47 rs1041573926 0.4153 None 0.044 N 0.31 0.161 0.368554958709 gnomAD-4.0.0 6.92527E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.68033E-05
T/I 28101 Fn3-92 47 rs1483336920 0.1231 -0.047 0.379 N 0.293 0.17 None gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 28101 Fn3-92 47 rs1483336920 0.1231 -0.047 0.379 N 0.293 0.17 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/I 28101 Fn3-92 47 rs1483336920 0.1231 -0.047 0.379 N 0.293 0.17 None gnomAD-4.0.0 6.40658E-06 None None None None I None 0 0 None 0 0 None 0 0 1.19657E-05 0 0
L/F 28200 Fn3-93 47 rs769081825 0.4186 -0.52 0.998 N 0.614 0.324 0.558227216974 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
L/F 28200 Fn3-93 47 rs769081825 0.4186 -0.52 0.998 N 0.614 0.324 0.558227216974 gnomAD-4.0.0 6.84426E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99671E-07 0 0
L/V 28200 Fn3-93 47 None 0.2427 None 0.979 N 0.569 0.255 0.501308276186 gnomAD-4.0.0 6.84426E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99671E-07 0 0
R/L 28298 Fn3-94 47 rs187270666 0.6168 None 0.987 N 0.459 0.438 0.472504041403 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/L 28298 Fn3-94 47 rs187270666 0.6168 None 0.987 N 0.459 0.438 0.472504041403 gnomAD-4.0.0 1.23952E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69519E-06 0 0
R/Q 28298 Fn3-94 47 None 0.2465 0.166 0.959 N 0.48 0.218 None gnomAD-2.1.1 1.44735E-03 None None None None N None 8.27E-05 0 None 0 1.54321E-04 None 1.30727E-04 None 1.19907E-02 6.56897E-04 1.82584E-03
R/Q 28298 Fn3-94 47 None 0.2465 0.166 0.959 N 0.48 0.218 None gnomAD-3.1.2 1.1505E-03 None None None None N None 7.24E-05 6.55E-05 0 0 1.93349E-04 None 1.33786E-02 0 3.82297E-04 4.14079E-04 0
R/Q 28298 Fn3-94 47 None 0.2465 0.166 0.959 N 0.48 0.218 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 0 2E-03 None None None 1E-03 None
R/Q 28298 Fn3-94 47 None 0.2465 0.166 0.959 N 0.48 0.218 None gnomAD-4.0.0 6.59377E-04 None None None None N None 5.33134E-05 1.66661E-05 None 0 2.00902E-04 None 1.1973E-02 0 1.93253E-04 8.78349E-05 7.84326E-04
R/W 28298 Fn3-94 47 rs779581886 0.4434 -0.405 1.0 N 0.672 0.428 None gnomAD-2.1.1 2.01E-05 None None None None N None 1.29182E-04 0 None 0 5.59E-05 None 0 None 4.65E-05 8.89E-06 0
R/W 28298 Fn3-94 47 rs779581886 0.4434 -0.405 1.0 N 0.672 0.428 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/W 28298 Fn3-94 47 rs779581886 0.4434 -0.405 1.0 N 0.672 0.428 None gnomAD-4.0.0 9.9164E-06 None None None None N None 5.3416E-05 0 None 0 2.23135E-05 None 1.56495E-05 0 6.78079E-06 2.19616E-05 0
A/P 28497 Fn3-95 48 None 0.3008 None 0.994 N 0.593 0.324 0.400468435593 gnomAD-4.0.0 6.84286E-07 None None None None I None 0 0 None 0 2.52372E-05 None 0 0 0 0 0
A/S 28497 Fn3-95 48 None 0.0929 None 0.919 N 0.517 0.155 0.227934060464 gnomAD-4.0.0 6.84286E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99468E-07 0 0
R/K 28596 Fn3-96 47 None 0.2194 None 0.603 N 0.493 0.235 0.177238962908 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/A 28697 Fn3-97 47 rs1559283455 0.1093 None 0.124 N 0.409 0.199 0.288727942641 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
D/A 28697 Fn3-97 47 rs1559283455 0.1093 None 0.124 N 0.409 0.199 0.288727942641 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/A 28697 Fn3-97 47 rs1559283455 0.1093 None 0.124 N 0.409 0.199 0.288727942641 gnomAD-4.0.0 6.57255E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
D/V 28697 Fn3-97 47 None 0.1069 None 0.497 N 0.545 0.291 0.449956787536 gnomAD-4.0.0 6.84251E-07 None None None None N None 0 0 None 0 2.52398E-05 None 0 0 0 0 0
D/Y 28697 Fn3-97 47 None 0.1767 None 0.859 D 0.588 0.332 0.568001609556 gnomAD-4.0.0 1.59153E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
A/P 28891 Fn3-98 47 rs535801518 0.8609 -0.281 0.314 N 0.318 0.157 0.200317383148 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 2.07383E-04 0
A/P 28891 Fn3-98 47 rs535801518 0.8609 -0.281 0.314 N 0.318 0.157 0.200317383148 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
A/P 28891 Fn3-98 47 rs535801518 0.8609 -0.281 0.314 N 0.318 0.157 0.200317383148 gnomAD-4.0.0 1.31349E-05 None None None None N None 2.40535E-05 0 None 0 0 None 0 0 0 2.07555E-04 0
A/S 28891 Fn3-98 47 rs535801518 0.13 None None N 0.269 0.093 0.124217242631 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/S 28891 Fn3-98 47 rs535801518 0.13 None None N 0.269 0.093 0.124217242631 gnomAD-4.0.0 2.54087E-05 None None None None N None 1.3349E-05 0 None 0 0 None 0 0 3.39058E-05 0 0
V/A 29184 Fn3-100 48 None 0.0737 None None N 0.091 0.082 0.0884992946249 gnomAD-4.0.0 6.84167E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99429E-07 0 0
V/G 29184 Fn3-100 48 None 0.1034 None 0.042 N 0.337 0.14 0.176091768786 gnomAD-4.0.0 1.36833E-06 None None None None I None 5.97372E-05 0 None 0 0 None 0 0 0 0 0
V/L 29184 Fn3-100 48 None 0.1061 None 0.042 N 0.221 0.132 0.231231049324 gnomAD-4.0.0 6.84161E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65645E-05
V/M 29184 Fn3-100 48 rs910283551 0.0958 -0.439 0.602 N 0.243 0.14 None gnomAD-2.1.1 1.2E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.66E-05 0
V/M 29184 Fn3-100 48 rs910283551 0.0958 -0.439 0.602 N 0.243 0.14 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/M 29184 Fn3-100 48 rs910283551 0.0958 -0.439 0.602 N 0.243 0.14 None gnomAD-4.0.0 1.17731E-05 None None None None I None 0 0 None 0 0 None 0 0 1.5256E-05 0 1.60092E-05
V/L 29580 Fn3-103 48 rs371096025 0.2881 -0.103 0.509 N 0.267 0.167 0.5763749866 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 9.95E-05 0 None 0 None 0 0 0
V/L 29580 Fn3-103 48 rs371096025 0.2881 -0.103 0.509 N 0.267 0.167 0.5763749866 gnomAD-4.0.0 1.59102E-06 None None None None I None 0 0 None 4.76644E-05 0 None 0 0 0 0 0
V/M 29580 Fn3-103 48 None 0.2223 -0.413 0.31 N 0.228 0.153 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
G/R 29679 Fn3-104 47 rs774651157 0.3177 0.011 None N 0.192 0.172 0.299427821978 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.56E-05 None 0 None 0 0 0
G/R 29679 Fn3-104 47 rs774651157 0.3177 0.011 None N 0.192 0.172 0.299427821978 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/R 29679 Fn3-104 47 rs774651157 0.3177 0.011 None N 0.192 0.172 0.299427821978 gnomAD-4.0.0 2.66471E-05 None None None None I None 0 0 None 0 0 None 0 0 3.55994E-05 0 1.60102E-05
T/I 29979 Fn3-106 47 rs779619858 0.3263 -0.015 0.801 N 0.284 0.409 0.41337360676 gnomAD-2.1.1 9.68E-05 None None None None N None 0 5.21921E-04 None 9.96E-05 0 None 0 None 0 1.78E-05 4.99667E-04
T/I 29979 Fn3-106 47 rs779619858 0.3263 -0.015 0.801 N 0.284 0.409 0.41337360676 gnomAD-3.1.2 1.70864E-04 None None None None N None 0 1.50622E-03 0 0 0 None 0 0 1.47E-05 0 9.56023E-04
T/I 29979 Fn3-106 47 rs779619858 0.3263 -0.015 0.801 N 0.284 0.409 0.41337360676 gnomAD-4.0.0 4.64989E-05 None None None None N None 0 9.0024E-04 None 3.37792E-05 0 None 0 0 1.10186E-05 0 1.12079E-04
T/R 29979 Fn3-106 47 rs779619858 0.5292 0.176 0.966 N 0.281 0.392 0.561027722634 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/R 29979 Fn3-106 47 rs779619858 0.5292 0.176 0.966 N 0.281 0.392 0.561027722634 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 29979 Fn3-106 47 rs779619858 0.5292 0.176 0.966 N 0.281 0.392 0.561027722634 gnomAD-4.0.0 6.57168E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
T/M 30076 Fn3-107 47 rs201998913 0.0739 -0.132 0.003 N 0.361 0.069 None gnomAD-2.1.1 3.57E-05 None None None None N None 2.89232E-04 0 None 0 5.13E-05 None 0 None 4E-05 0 1.40331E-04
T/M 30076 Fn3-107 47 rs201998913 0.0739 -0.132 0.003 N 0.361 0.069 None gnomAD-3.1.2 1.1171E-04 None None None None N None 3.13601E-04 0 0 0 0 None 2.82699E-04 0 1.47E-05 0 0
T/M 30076 Fn3-107 47 rs201998913 0.0739 -0.132 0.003 N 0.361 0.069 None gnomAD-4.0.0 3.34613E-05 None None None None N None 3.06953E-04 0 None 0 0 None 1.87471E-04 0 1.44085E-05 0 3.20174E-05
L/F 30370 Fn3-109 47 rs876658092 0.3271 -0.7 0.999 N 0.574 0.246 0.517655672 gnomAD-2.1.1 7.15E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.57E-05 0
L/F 30370 Fn3-109 47 rs876658092 0.3271 -0.7 0.999 N 0.574 0.246 0.517655672 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 30370 Fn3-109 47 rs876658092 0.3271 -0.7 0.999 N 0.574 0.246 0.517655672 gnomAD-4.0.0 6.40576E-06 None None None None I None 0 0 None 0 0 None 0 0 9.57158E-06 1.34027E-05 0
R/C 30467 Fn3-110 46 rs775591945 0.3805 -0.078 1.0 N 0.551 0.288 None gnomAD-2.1.1 5.72E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 1.0179E-04 1.40845E-04
R/C 30467 Fn3-110 46 rs775591945 0.3805 -0.078 1.0 N 0.551 0.288 None gnomAD-3.1.2 1.05255E-04 None None None None N None 9.67E-05 0 0 0 1.92976E-04 None 0 0 1.61731E-04 0 0
R/C 30467 Fn3-110 46 rs775591945 0.3805 -0.078 1.0 N 0.551 0.288 None gnomAD-4.0.0 1.76042E-04 None None None None N None 6.68271E-05 5.004E-05 None 0 8.93017E-05 None 0 0 2.23796E-04 3.29424E-05 8.00717E-05
R/H 30467 Fn3-110 46 rs572793448 0.1637 -0.555 0.26 N 0.301 0.145 None gnomAD-2.1.1 2.15E-05 None None None None N None 2.06817E-04 0 None 0 0 None 0 None 0 7.83E-06 0
R/H 30467 Fn3-110 46 rs572793448 0.1637 -0.555 0.26 N 0.301 0.145 None gnomAD-3.1.2 8.54E-05 None None None None N None 3.13813E-04 0 0 0 0 None 0 0 0 0 0
R/H 30467 Fn3-110 46 rs572793448 0.1637 -0.555 0.26 N 0.301 0.145 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/H 30467 Fn3-110 46 rs572793448 0.1637 -0.555 0.26 N 0.301 0.145 None gnomAD-4.0.0 1.36348E-05 None None None None N None 2.13333E-04 0 None 0 8.93136E-05 None 0 0 8.47693E-07 0 1.60097E-05
R/S 30467 Fn3-110 46 None 0.6932 None 0.956 N 0.523 0.229 0.341934017632 gnomAD-4.0.0 6.84349E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99575E-07 0 0
A/T 30666 Fn3-111 48 None 0.1367 None 0.201 N 0.423 0.035 0.211220785272 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 30666 Fn3-111 48 None 0.2141 None 0.334 N 0.403 0.293 0.425028116352 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/G 30765 Fn3-112 47 None 0.5793 None 0.997 N 0.445 0.311 0.315903272564 gnomAD-4.0.0 1.59105E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
R/K 30765 Fn3-112 47 rs373099440 0.2123 0.028 0.928 N 0.51 0.183 0.363158594168 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/K 30765 Fn3-112 47 rs373099440 0.2123 0.028 0.928 N 0.51 0.183 0.363158594168 gnomAD-4.0.0 1.36836E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99437E-07 1.15934E-05 0
R/T 30765 Fn3-112 47 rs373099440 0.6811 0.046 0.969 D 0.451 0.294 None gnomAD-2.1.1 1.31908E-04 None None None None N None 1.447E-03 2.83E-05 None 0 0 None 0 None 0 0 1.40135E-04
R/T 30765 Fn3-112 47 rs373099440 0.6811 0.046 0.969 D 0.451 0.294 None gnomAD-3.1.2 5.71624E-04 None None None None N None 1.9291E-03 4.58475E-04 0 0 0 None 0 0 0 0 0
R/T 30765 Fn3-112 47 rs373099440 0.6811 0.046 0.969 D 0.451 0.294 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
R/T 30765 Fn3-112 47 rs373099440 0.6811 0.046 0.969 D 0.451 0.294 None gnomAD-4.0.0 8.92235E-05 None None None None N None 1.71876E-03 2.16631E-04 None 0 0 None 0 0 0 0 3.20082E-05
S/G 31062 Fn3-114 47 None 0.1636 None 0.973 N 0.415 0.135 0.212008924253 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 1.88267E-05 0 0 0 0
F/L 31159 Fn3-115 47 rs765476463 0.431 -0.312 None N 0.071 0.194 0.270001397563 gnomAD-2.1.1 8.03E-06 None None None None I None 0 2.9E-05 None 0 5.56E-05 None 0 None 0 0 0
F/L 31159 Fn3-115 47 rs765476463 0.431 -0.312 None N 0.071 0.194 0.270001397563 gnomAD-4.0.0 1.11375E-05 None None None None I None 0 2.28634E-05 None 0 1.66352E-04 None 0 0 0 0 0
F/S 31159 Fn3-115 47 rs1469115773 0.1 None 0.086 N 0.383 0.216 0.37568098594 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/V 31159 Fn3-115 47 None 0.0711 None None N 0.151 0.207 0.337378238328 gnomAD-4.0.0 1.59107E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
A/G 31355 Fn3-116 48 None 0.1596 None 0.027 N 0.346 0.143 0.355242300401 gnomAD-4.0.0 6.84203E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99447E-07 0 0
A/P 31355 Fn3-116 48 None 0.6999 None 0.317 N 0.327 0.161 0.482137172311 gnomAD-4.0.0 6.84202E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
A/T 31355 Fn3-116 48 rs780964196 0.0678 -0.336 0.002 N 0.223 0.061 0.30921473904 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 1.1162E-04 None 0 None 0 0 0
A/T 31355 Fn3-116 48 rs780964196 0.0678 -0.336 0.002 N 0.223 0.061 0.30921473904 gnomAD-4.0.0 1.3684E-06 None None None None I None 0 0 None 0 5.04159E-05 None 0 0 0 0 0
A/V 31355 Fn3-116 48 rs370666551 0.1069 -0.121 0.117 N 0.291 0.108 None gnomAD-2.1.1 2.5E-05 None None None None I None 0 0 None 0 0 None 0 None 0 4.69E-05 1.40371E-04
A/V 31355 Fn3-116 48 rs370666551 0.1069 -0.121 0.117 N 0.291 0.108 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
A/V 31355 Fn3-116 48 rs370666551 0.1069 -0.121 0.117 N 0.291 0.108 None gnomAD-4.0.0 3.03654E-05 None None None None I None 0 0 None 0 0 None 0 0 3.9837E-05 0 3.20236E-05
L/F 31454 Fn3-117 47 rs758766295 0.7551 -0.519 1.0 N 0.577 0.31 0.628150982837 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/F 31454 Fn3-117 47 rs758766295 0.7551 -0.519 1.0 N 0.577 0.31 0.628150982837 gnomAD-4.0.0 5.47357E-06 None None None None I None 0 0 None 0 0 None 0 0 0 9.2745E-05 0
L/I 31454 Fn3-117 47 rs758766295 0.3896 -0.13 0.999 N 0.471 0.253 0.559044820595 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.87E-06 0
L/I 31454 Fn3-117 47 rs758766295 0.3896 -0.13 0.999 N 0.471 0.253 0.559044820595 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 2.88184E-04 0 None 0 0 0 0 0
L/I 31454 Fn3-117 47 rs758766295 0.3896 -0.13 0.999 N 0.471 0.253 0.559044820595 gnomAD-4.0.0 2.4788E-06 None None None None I None 0 0 None 1.01365E-04 0 None 0 0 8.47606E-07 0 0
R/C 31555 Fn3-118 50 rs757099797 0.5976 -0.48 1.0 N 0.811 0.421 0.785964137318 gnomAD-2.1.1 8.06E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.93E-06 0
R/C 31555 Fn3-118 50 rs757099797 0.5976 -0.48 1.0 N 0.811 0.421 0.785964137318 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
R/C 31555 Fn3-118 50 rs757099797 0.5976 -0.48 1.0 N 0.811 0.421 0.785964137318 gnomAD-4.0.0 7.43707E-06 None None None None N None 4.00716E-05 3.33467E-05 None 0 0 None 0 0 5.93353E-06 0 0
R/G 31555 Fn3-118 50 rs757099797 0.7979 -0.673 1.0 D 0.692 0.401 0.706445215409 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
R/G 31555 Fn3-118 50 rs757099797 0.7979 -0.673 1.0 D 0.692 0.401 0.706445215409 gnomAD-4.0.0 4.78956E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11632E-05 0
R/H 31555 Fn3-118 50 rs727503545 0.2993 -0.901 1.0 N 0.839 0.427 0.423597194605 gnomAD-2.1.1 6.8E-05 None None None None N None 0 3.67938E-04 None 0 0 None 0 None 0 2.35E-05 4.21467E-04
R/H 31555 Fn3-118 50 rs727503545 0.2993 -0.901 1.0 N 0.839 0.427 0.423597194605 gnomAD-3.1.2 3.95E-05 None None None None N None 0 2.62055E-04 0 0 0 None 0 0 1.47E-05 2.07211E-04 0
R/H 31555 Fn3-118 50 rs727503545 0.2993 -0.901 1.0 N 0.839 0.427 0.423597194605 gnomAD-4.0.0 2.293E-05 None None None None N None 0 4.16792E-04 None 3.37838E-05 0 None 0 0 5.93345E-06 1.09794E-05 4.80323E-05
R/L 31555 Fn3-118 50 rs727503545 0.7066 None 1.0 D 0.692 0.388 0.705509371873 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79899E-06 0 0
R/S 31555 Fn3-118 50 None 0.9193 None 1.0 N 0.721 0.419 0.542187413537 gnomAD-4.0.0 6.84226E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15955E-05 0
N/T 31754 Fn3-119 47 None 0.1965 None 0.904 N 0.435 0.409 0.243972157842 gnomAD-4.0.0 1.59121E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85814E-06 0 0
R/C 31853 Fn3-120 47 rs727503542 0.3766 -0.385 0.996 D 0.631 0.372 0.416328079214 gnomAD-2.1.1 1.78E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.9E-05 0
R/C 31853 Fn3-120 47 rs727503542 0.3766 -0.385 0.996 D 0.631 0.372 0.416328079214 gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 4.78011E-04
R/C 31853 Fn3-120 47 rs727503542 0.3766 -0.385 0.996 D 0.631 0.372 0.416328079214 gnomAD-4.0.0 3.78017E-05 None None None None N None 6.66524E-05 0 None 0 0 None 0 0 4.57742E-05 0 3.20143E-05
R/H 31853 Fn3-120 47 rs754151944 0.2062 -0.896 0.02 N 0.304 0.23 0.21737058555 gnomAD-2.1.1 8.2E-05 None None None None N None 0 2.83E-05 None 0 1.02449E-04 None 0 None 1.19894E-04 1.32612E-04 0
R/H 31853 Fn3-120 47 rs754151944 0.2062 -0.896 0.02 N 0.304 0.23 0.21737058555 gnomAD-3.1.2 1.05161E-04 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.2051E-04 0 0
R/H 31853 Fn3-120 47 rs754151944 0.2062 -0.896 0.02 N 0.304 0.23 0.21737058555 gnomAD-4.0.0 2.29298E-05 None None None None N None 1.33494E-05 1.66689E-05 None 0 6.68509E-05 None 1.24973E-04 0 1.86486E-05 0 3.20246E-05
R/S 31853 Fn3-120 47 rs727503542 0.8662 None 0.561 N 0.449 0.196 0.284150004643 gnomAD-4.0.0 6.84242E-07 None None None None N None 2.98811E-05 0 None 0 0 None 0 0 0 0 0
Q/L 31955 Fn3-121 47 rs552683796 0.1319 0.224 0.324 N 0.337 0.343 0.443999229985 gnomAD-2.1.1 3.62E-05 None None None None N None 0 0 None 0 0 None 2.94098E-04 None 0 0 0
Q/L 31955 Fn3-121 47 rs552683796 0.1319 0.224 0.324 N 0.337 0.343 0.443999229985 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14594E-04 0
Q/L 31955 Fn3-121 47 rs552683796 0.1319 0.224 0.324 N 0.337 0.343 0.443999229985 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
Q/L 31955 Fn3-121 47 rs552683796 0.1319 0.224 0.324 N 0.337 0.343 0.443999229985 gnomAD-4.0.0 1.3632E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.19597E-04 3.20092E-05
R/S 32248 Fn3-123 47 None 0.4547 None 0.896 N 0.439 0.236 0.237489013734 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 32446 Fn3-124 48 None 0.8079 None 1.0 N 0.655 0.425 0.467839254973 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
G/V 32446 Fn3-124 48 rs1410045812 0.4236 0.149 1.0 N 0.686 0.441 0.479133204078 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/V 32446 Fn3-124 48 rs1410045812 0.4236 0.149 1.0 N 0.686 0.441 0.479133204078 gnomAD-4.0.0 1.59154E-06 None None None None I None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
R/Q 32545 Fn3-125 47 rs754540983 0.1926 0.215 1.0 N 0.697 0.354 0.264081493735 gnomAD-2.1.1 1.61E-05 None None None None I None 0 8.71E-05 None 0 0 None 0 None 0 8.88E-06 0
R/Q 32545 Fn3-125 47 rs754540983 0.1926 0.215 1.0 N 0.697 0.354 0.264081493735 gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/Q 32545 Fn3-125 47 rs754540983 0.1926 0.215 1.0 N 0.697 0.354 0.264081493735 gnomAD-4.0.0 1.4876E-05 None None None None I None 8.01154E-05 5.00283E-05 None 0 0 None 0 0 1.18685E-05 0 1.60185E-05
A/S 32842 Fn3-127 48 rs199647622 0.138 -0.475 1.0 N 0.554 0.297 0.336155897331 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.55E-05 0
A/S 32842 Fn3-127 48 rs199647622 0.138 -0.475 1.0 N 0.554 0.297 0.336155897331 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
A/S 32842 Fn3-127 48 rs199647622 0.138 -0.475 1.0 N 0.554 0.297 0.336155897331 gnomAD-4.0.0 9.29568E-06 None None None None I None 0 0 None 0 0 None 0 0 1.27143E-05 0 0
A/T 32842 Fn3-127 48 rs199647622 0.2063 -0.388 1.0 N 0.587 0.314 0.386721274199 gnomAD-2.1.1 6.07E-05 None None None None I None 4.13E-05 2.54439E-04 None 0 0 None 9.8E-05 None 0 2.34E-05 1.40331E-04
A/T 32842 Fn3-127 48 rs199647622 0.2063 -0.388 1.0 N 0.587 0.314 0.386721274199 gnomAD-3.1.2 1.32E-05 None None None None I None 2.42E-05 6.55E-05 0 0 0 None 0 0 0 0 0
A/T 32842 Fn3-127 48 rs199647622 0.2063 -0.388 1.0 N 0.587 0.314 0.386721274199 gnomAD-4.0.0 2.54082E-05 None None None None I None 2.67115E-05 1.66711E-04 None 0 0 None 0 0 1.61047E-05 9.88077E-05 1.60102E-05
A/G 33044 Fn3-129 47 None 0.1299 None 0.822 N 0.501 0.22 0.269558022972 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8586E-06 0 0
A/V 33044 Fn3-129 47 rs548242100 0.0938 -0.21 0.698 N 0.477 0.21 0.31291088546 gnomAD-2.1.1 1.21E-05 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 8.87E-06 0
A/V 33044 Fn3-129 47 rs548242100 0.0938 -0.21 0.698 N 0.477 0.21 0.31291088546 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 33044 Fn3-129 47 rs548242100 0.0938 -0.21 0.698 N 0.477 0.21 0.31291088546 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
A/V 33044 Fn3-129 47 rs548242100 0.0938 -0.21 0.698 N 0.477 0.21 0.31291088546 gnomAD-4.0.0 3.84377E-06 None None None None N None 0 3.38891E-05 None 0 0 None 0 0 2.39342E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.