Structural position:

  • Domain Type: Ig
  • Aligned Position: 11
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A'

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
S/I 14 Ig-1 9 rs771027745 0.6687 0.169 1.0 N 0.802 0.397 0.675737440431 gnomAD-2.1.1 3.98E-06 None None None -0.816(TCAP) N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
S/I 14 Ig-1 9 rs771027745 0.6687 0.169 1.0 N 0.802 0.397 0.675737440431 gnomAD-4.0.0 5.47299E-06 None None None -0.816(TCAP) N None 0 0 None 0 0 None 0 0 7.19472E-06 0 0
S/N 14 Ig-1 9 rs771027745 0.1838 None 0.998 N 0.593 0.295 0.367425347029 gnomAD-4.0.0 6.84124E-07 None None None -0.592(TCAP) N None 0 0 None 0 0 None 0 0 8.9934E-07 0 0
S/C 112 Ig-2 9 None 0.7332 None 1.0 D 0.666 0.698 0.706202814552 gnomAD-3.1.2 6.57E-06 None None None -0.202(TCAP) N None 0 0 0 0 1.9253E-04 None 0 0 0 0 0
S/C 112 Ig-2 9 None 0.7332 None 1.0 D 0.666 0.698 0.706202814552 gnomAD-4.0.0 2.57113E-06 None None None -0.202(TCAP) N None 0 0 None 0 4.85131E-05 None 0 0 0 0 0
S/N 112 Ig-2 9 None 0.3208 None 0.859 N 0.491 0.27 0.243972157842 gnomAD-4.0.0 6.8547E-07 None None None -0.782(TCAP) N None 0 0 None 0 0 None 0 0 9.00576E-07 0 0
V/I 1090 Ig-4 9 rs1419239601 0.1005 None None N 0.127 0.104 0.259761712551 gnomAD-4.0.0 1.36815E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99298E-07 0 1.6559E-05
N/S 1299 Ig-5 9 rs1219843676 0.3419 -0.417 0.17 N 0.196 0.064 0.0762999501168 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 9.95E-05 0 None 0 None 0 0 0
N/S 1299 Ig-5 9 rs1219843676 0.3419 -0.417 0.17 N 0.196 0.064 0.0762999501168 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 4.76735E-05 0 None 0 0 0 0 0
N/Y 1299 Ig-5 9 rs1304157069 0.8557 None 0.997 N 0.665 0.491 0.468753983522 gnomAD-4.0.0 1.20051E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31272E-06 0 0
S/Y 1465 Ig-6 9 rs2092386112 0.6926 None 0.999 D 0.575 0.669 0.849710504893 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/Y 1465 Ig-6 9 rs2092386112 0.6926 None 0.999 D 0.575 0.669 0.849710504893 gnomAD-4.0.0 6.57194E-06 None None None None I None 0 6.54707E-05 None 0 0 None 0 0 0 0 0
S/F 1711 Ig-8 9 rs397517641 0.8956 -1.011 1.0 D 0.816 0.676 0.845695947675 gnomAD-2.1.1 1.06E-05 None None None None N None 4.01E-05 0 None 0 0 None 0 None 0 0 2.78009E-04
S/F 1711 Ig-8 9 rs397517641 0.8956 -1.011 1.0 D 0.816 0.676 0.845695947675 gnomAD-3.1.2 5.26E-05 None None None None N None 0 3.92516E-04 0 0 0 None 0 0 1.47E-05 0 4.78469E-04
S/F 1711 Ig-8 9 rs397517641 0.8956 -1.011 1.0 D 0.816 0.676 0.845695947675 gnomAD-4.0.0 1.05323E-05 None None None None N None 1.33273E-05 1.16647E-04 None 0 0 None 0 0 8.47449E-07 0 1.27988E-04
S/P 1711 Ig-8 9 None 0.4372 None 1.0 N 0.812 0.68 0.450055297382 gnomAD-4.0.0 1.59066E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
P/A 1849 Ig-9 9 rs771747683 0.117 -0.732 1.0 N 0.708 0.381 0.254244900254 gnomAD-2.1.1 1.19E-05 None None None None N None 0 0 None 0 1.63221E-04 None 0 None 0 0 0
P/A 1849 Ig-9 9 rs771747683 0.117 -0.732 1.0 N 0.708 0.381 0.254244900254 gnomAD-4.0.0 3.42084E-06 None None None None N None 0 0 None 0 7.55744E-05 None 0 0 0 0 3.31159E-05
D/V 2182 Ig-11 9 None 0.8443 None 1.0 D 0.838 0.671 0.719514389011 gnomAD-4.0.0 1.59085E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85683E-06 0 0
D/H 2364 Ig-13 9 rs1429499866 0.6682 -0.043 1.0 D 0.684 0.725 0.654805944736 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
D/H 2364 Ig-13 9 rs1429499866 0.6682 -0.043 1.0 D 0.684 0.725 0.654805944736 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 2364 Ig-13 9 rs1429499866 0.6682 -0.043 1.0 D 0.684 0.725 0.654805944736 gnomAD-4.0.0 6.57402E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
D/N 2364 Ig-13 9 None 0.1332 None 1.0 D 0.613 0.585 0.57186346447 gnomAD-4.0.0 1.59076E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
D/A 2453 Ig-14 9 None 0.3903 None 1.0 D 0.717 0.575 0.352048277211 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 2453 Ig-14 9 rs1002418895 0.402 -0.078 1.0 D 0.415 0.326 0.295974979623 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
D/E 2453 Ig-14 9 rs1002418895 0.402 -0.078 1.0 D 0.415 0.326 0.295974979623 gnomAD-4.0.0 1.59072E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85673E-06 0 0
D/E 2541 Ig-15 9 rs2091808805 0.5081 None 0.996 D 0.411 0.318 0.341934017632 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 2541 Ig-15 9 rs1462842843 0.6771 None 1.0 D 0.743 0.477 0.576874179423 gnomAD-4.0.0 3.18167E-06 None None None None N None 5.65419E-05 0 None 4.7669E-05 0 None 0 0 0 0 0
D/N 2628 Ig-16 8 rs1401260023 0.18 None 1.0 N 0.631 0.377 0.434716162284 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 2628 Ig-16 8 rs1401260023 0.18 None 1.0 N 0.631 0.377 0.434716162284 gnomAD-4.0.0 3.84271E-06 None None None None N None 0 1.69486E-05 None 0 0 None 0 0 2.39272E-06 0 2.84301E-05
N/S 2715 Ig-17 9 None 0.4679 None 0.999 D 0.512 0.606 0.436993770938 gnomAD-4.0.0 6.84387E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99315E-07 0 0
D/N 2803 Ig-18 9 rs1457989871 0.4672 -0.512 1.0 N 0.607 0.346 0.195762928549 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.84E-06 0
D/N 2803 Ig-18 9 rs1457989871 0.4672 -0.512 1.0 N 0.607 0.346 0.195762928549 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/D 2890 Ig-19 9 rs767589357 0.0805 0.553 None N 0.104 0.162 0.223847106136 gnomAD-2.1.1 2.39E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.3E-05 0
N/D 2890 Ig-19 9 rs767589357 0.0805 0.553 None N 0.104 0.162 0.223847106136 gnomAD-4.0.0 1.7496E-05 None None None None N None 0 0 None 0 0 None 0 0 3.14217E-05 0 0
N/S 2890 Ig-19 9 rs1574561545 0.06 None None N 0.089 0.159 0.0297737177859 gnomAD-4.0.0 1.36816E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7986E-06 0 0
N/T 2890 Ig-19 9 None 0.0948 None 0.027 D 0.249 0.245 0.128392430309 gnomAD-4.0.0 6.84082E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99298E-07 0 0
D/N 2977 Ig-20 9 None 0.5053 None 1.0 N 0.602 0.389 0.141422826196 gnomAD-4.0.0 1.59098E-06 None None None None N None 0 0 None 0 2.77824E-05 None 0 0 0 0 0
E/Q 3155 Ig-22 9 rs1458652114 0.2859 None 0.016 N 0.237 0.084 0.257292322809 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 3155 Ig-22 9 rs1458652114 0.2859 None 0.016 N 0.237 0.084 0.257292322809 gnomAD-4.0.0 2.02981E-06 None None None None I None 0 0 None 0 0 None 0 0 2.40982E-06 0 0
P/L 3247 Ig-23 9 None 0.2607 None 1.0 D 0.797 0.53 0.788987795477 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
P/T 3247 Ig-23 9 rs2090057344 0.1783 None 0.999 N 0.813 0.391 0.544477446313 gnomAD-4.0.0 1.59154E-06 None None None None N None 0 0 None 0 0 None 0 2.53421E-04 0 0 0
D/N 3353 Ig-24 9 None 0.1259 None 0.576 N 0.262 0.248 0.258779203287 gnomAD-4.0.0 1.5906E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85673E-06 0 0
S/I 3473 Ig-25 9 rs1574398380 0.5437 None None None None 0.305 None gnomAD-4.0.0 1.59454E-06 None None None None N None 0 2.28854E-05 None 0 0 None 0 0 0 0 0
D/H 3668 Ig-26 9 rs2086998453 0.4942 None None None None 0.188 None gnomAD-4.0.0 1.59133E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
D/V 3668 Ig-26 9 None 0.5523 None None None None 0.171 None gnomAD-4.0.0 6.84217E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9946E-07 0 0
N/H 3828 Ig-27 9 None 0.1025 None 0.295 N 0.369 0.057 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 3828 Ig-27 9 None 0.2672 None 0.024 N 0.222 0.069 None gnomAD-4.0.0 1.59162E-06 None None None None N None 0 2.28812E-05 None 0 0 None 0 0 0 0 0
N/S 3828 Ig-27 9 None 0.0647 None 0.012 N 0.311 0.121 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
P/L 3946 Ig-28 9 None 0.1758 None 0.565 N 0.517 0.206 None gnomAD-4.0.0 1.59107E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02389E-05
P/S 3946 Ig-28 9 rs970485392 0.1086 -0.719 0.075 N 0.307 0.071 None gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
P/S 3946 Ig-28 9 rs970485392 0.1086 -0.719 0.075 N 0.307 0.071 None gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
P/S 3946 Ig-28 9 rs970485392 0.1086 -0.719 0.075 N 0.307 0.071 None gnomAD-4.0.0 4.33771E-06 None None None None I None 8.00854E-05 0 None 0 0 None 0 0 0 0 1.60113E-05
P/T 3946 Ig-28 9 rs970485392 0.1081 None 0.565 N 0.481 0.063 None gnomAD-4.0.0 4.10504E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39658E-06 0 0
P/A 4708 Ig-30 9 None 0.0924 None 0.007 N 0.136 0.068 0.0846915920261 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/L 4708 Ig-30 9 rs778412304 0.2212 0.05 0.549 N 0.375 0.248 None gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/L 4708 Ig-30 9 rs778412304 0.2212 0.05 0.549 N 0.375 0.248 None gnomAD-4.0.0 5.47686E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19902E-06 0 0
P/T 4708 Ig-30 9 None 0.1335 None 0.379 N 0.221 0.062 0.132336055621 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/C 4803 Ig-31 9 None 0.2087 None 0.78 N 0.378 0.254 0.277730125212 gnomAD-4.0.0 6.87705E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02757E-07 0 0
S/F 4803 Ig-31 9 rs774228049 0.342 -0.764 0.484 N 0.454 0.263 0.377799810692 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.04E-06 0
S/F 4803 Ig-31 9 rs774228049 0.342 -0.764 0.484 N 0.454 0.263 0.377799810692 gnomAD-4.0.0 1.10033E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44441E-05 0 0
S/Y 4803 Ig-31 9 None 0.2429 None 0.484 N 0.456 0.233 0.379366414296 gnomAD-4.0.0 6.87705E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02757E-07 0 0
P/S 4896 Ig-32 9 None 0.0983 None 0.001 N 0.19 0.083 0.0806252709748 gnomAD-4.0.0 2.40064E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
P/L 4989 Ig-33 9 rs1560844298 0.1872 None 1.0 N 0.757 0.372 0.504297271243 gnomAD-4.0.0 3.26883E-06 None None None None N None 0 0 None 0 0 None 0 0 2.94149E-06 0 3.07598E-05
P/S 4989 Ig-33 9 rs80003323 0.1446 -0.194 1.0 N 0.739 0.321 0.144782658237 gnomAD-2.1.1 4.47E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.01E-05 0
P/S 4989 Ig-33 9 rs80003323 0.1446 -0.194 1.0 N 0.739 0.321 0.144782658237 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 4989 Ig-33 9 rs80003323 0.1446 -0.194 1.0 N 0.739 0.321 0.144782658237 gnomAD-4.0.0 6.26231E-06 None None None None N None 0 0 None 0 0 None 0 0 8.54791E-06 0 0
P/T 4989 Ig-33 9 rs80003323 0.1344 -0.209 1.0 N 0.724 0.327 None gnomAD-2.1.1 4.47E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.01E-05 0
P/T 4989 Ig-33 9 rs80003323 0.1344 -0.209 1.0 N 0.724 0.327 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
P/T 4989 Ig-33 9 rs80003323 0.1344 -0.209 1.0 N 0.724 0.327 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
P/T 4989 Ig-33 9 rs80003323 0.1344 -0.209 1.0 N 0.724 0.327 None gnomAD-4.0.0 1.00189E-05 None None None None N None 0 0 None 0 0 None 0 1.66113E-04 1.11124E-05 0 3.22956E-05
P/A 5083 Ig-34 9 None 0.0955 None 0.183 D 0.301 0.27 0.231231049324 gnomAD-4.0.0 9.80048E-06 None None None None N None 0 0 None 0 0 None 0 0 1.27838E-05 0 0
P/T 5083 Ig-34 9 rs1465484453 0.1494 None 0.003 N 0.107 0.225 0.332133492242 gnomAD-4.0.0 1.40007E-06 None None None None N None 0 0 None 0 0 None 0 0 1.82626E-06 0 0
D/Y 5176 Ig-35 9 rs1421517847 0.2821 0.052 0.975 D 0.404 0.359 0.574670332726 gnomAD-2.1.1 4.09E-06 None None None None N None 0 2.97E-05 None 0 0 None 0 None 0 0 0
D/Y 5176 Ig-35 9 rs1421517847 0.2821 0.052 0.975 D 0.404 0.359 0.574670332726 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96489E-04 0 0 0 None 0 0 0 0 0
D/Y 5176 Ig-35 9 rs1421517847 0.2821 0.052 0.975 D 0.404 0.359 0.574670332726 gnomAD-4.0.0 3.12136E-06 None None None None N None 0 6.75721E-05 None 0 0 None 0 0 8.5355E-07 0 0
L/P 5269 Ig-36 9 None 0.1309 None 0.927 N 0.418 0.289 0.449379577644 gnomAD-4.0.0 7.53545E-06 None None None None I None 0 2.24155E-05 None 0 0 None 0 0 9.00494E-06 0 0
N/D 5365 Ig-37 9 None 0.1112 None 0.002 N 0.104 0.121 0.112648838833 gnomAD-4.0.0 1.37739E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80837E-06 0 0
N/I 5365 Ig-37 9 rs2080837550 0.2728 None 0.487 N 0.384 0.189 0.450152462452 gnomAD-4.0.0 1.60988E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89491E-06 0 0
N/K 5365 Ig-37 9 rs72648935 0.2721 0.497 0.018 N 0.093 0.057 0.0297737177859 gnomAD-2.1.1 4.12E-06 None None None None N None 0 2.97E-05 None 0 0 None 0 None 0 0 0
N/K 5365 Ig-37 9 rs72648935 0.2721 0.497 0.018 N 0.093 0.057 0.0297737177859 gnomAD-4.0.0 6.87793E-07 None None None None N None 0 2.26613E-05 None 0 0 None 0 0 0 0 0
N/Y 5365 Ig-37 9 rs878854288 0.2044 -0.396 0.794 N 0.315 0.328 0.44750879378 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
P/L 5551 Ig-39 9 rs762729065 0.0952 0.097 None N 0.204 0.135 0.269111216191 gnomAD-2.1.1 4.11E-06 None None None None I None 0 0 None 1.04188E-04 0 None 0 None 0 0 0
P/L 5551 Ig-39 9 rs762729065 0.0952 0.097 None N 0.204 0.135 0.269111216191 gnomAD-4.0.0 1.61106E-06 None None None None I None 0 0 None 4.85767E-05 0 None 0 0 0 0 0
P/T 5551 Ig-39 9 rs1578181149 0.0867 None 0.062 N 0.289 0.061 0.177238962908 gnomAD-4.0.0 1.08029E-05 None None None None I None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
P/L 5645 Ig-40 9 rs370889765 0.1589 -0.059 None N 0.278 0.164 None gnomAD-2.1.1 1.47202E-04 None None None None N None 0 0 None 1.27028E-03 0 None 0 None 0 2.12211E-04 1.41523E-04
P/L 5645 Ig-40 9 rs370889765 0.1589 -0.059 None N 0.278 0.164 None gnomAD-3.1.2 8.55E-05 None None None None N None 0 6.56E-05 0 1.1534E-03 0 None 0 0 1.17616E-04 0 0
P/L 5645 Ig-40 9 rs370889765 0.1589 -0.059 None N 0.278 0.164 None gnomAD-4.0.0 1.00039E-04 None None None None N None 0 1.67118E-05 None 9.84319E-04 0 None 0 0 1.06239E-04 0 9.63732E-05
P/T 5645 Ig-40 9 None 0.099 None 0.012 N 0.292 0.047 0.101711395817 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/Y 5831 Ig-42 9 rs760944340 0.3499 -0.523 1.0 N 0.805 0.364 0.622579596728 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
S/Y 5831 Ig-42 9 rs760944340 0.3499 -0.523 1.0 N 0.805 0.364 0.622579596728 gnomAD-4.0.0 1.36868E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79925E-06 0 0
K/Q 5927 Ig-43 9 None 0.123 None 0.31 N 0.167 0.108 0.115124310173 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/A 6207 Ig-46 9 rs755803926 0.076 -0.766 0.039 N 0.405 0.215 0.112648838833 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
P/A 6207 Ig-46 9 rs755803926 0.076 -0.766 0.039 N 0.405 0.215 0.112648838833 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
P/S 6207 Ig-46 9 None 0.1088 None 0.957 N 0.708 0.312 0.126345400529 gnomAD-4.0.0 3.18619E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72439E-06 0 0
N/S 6300 Ig-47 9 None 0.2637 None 0.996 N 0.343 0.242 0.146414634003 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
K/E 6489 Ig-49 9 None 0.1659 None 0.134 N 0.116 0.078 0.1749357433 gnomAD-4.0.0 1.61465E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.47189E-05 0
R/Q 6582 Ig-50 9 rs776051087 0.075 -0.096 0.953 N 0.336 0.213 None gnomAD-2.1.1 2.96E-05 None None None None I None 8.35E-05 3E-05 None 0 0 None 7.17E-05 None 0 1.6E-05 1.46071E-04
R/Q 6582 Ig-50 9 rs776051087 0.075 -0.096 0.953 N 0.336 0.213 None gnomAD-3.1.2 5.92E-05 None None None None I None 1.20755E-04 0 0 0 0 None 0 0 4.41E-05 0 4.78469E-04
R/Q 6582 Ig-50 9 rs776051087 0.075 -0.096 0.953 N 0.336 0.213 None gnomAD-4.0.0 2.81502E-05 None None None None I None 1.07637E-04 1.71727E-05 None 3.44187E-05 0 None 1.57015E-05 0 1.96177E-05 1.0281E-04 3.23771E-05
A/D 6675 Ig-51 9 None 0.2739 None 0.901 N 0.518 0.182 0.215869574891 gnomAD-4.0.0 6.89045E-07 None None None None I None 0 0 None 0 0 None 0 0 9.03599E-07 0 0
A/V 6675 Ig-51 9 rs778363589 0.1374 0.066 0.008 N 0.207 0.096 0.141422826196 gnomAD-2.1.1 4.14E-06 None None None None I None 0 3.01E-05 None 0 0 None 0 None 0 0 0
A/V 6675 Ig-51 9 rs778363589 0.1374 0.066 0.008 N 0.207 0.096 0.141422826196 gnomAD-4.0.0 6.89045E-07 None None None None I None 0 2.30563E-05 None 0 0 None 0 0 0 0 0
I/T 6769 Ig-52 9 None 0.0706 None 0.003 N 0.247 0.101 0.49342883329 gnomAD-4.0.0 1.76423E-06 None None None None N None 0 0 None 0 0 None 1.92456E-05 0 0 0 0
I/V 6769 Ig-52 9 rs1212523290 0.0547 -0.313 None N 0.044 0.055 0.28058544554 gnomAD-2.1.1 9.29E-06 None None None None N None 0 3.73E-05 None 0 0 None 0 None 0 9.86E-06 0
I/V 6769 Ig-52 9 rs1212523290 0.0547 -0.313 None N 0.044 0.055 0.28058544554 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92753E-04 None 0 0 0 0 0
I/V 6769 Ig-52 9 rs1212523290 0.0547 -0.313 None N 0.044 0.055 0.28058544554 gnomAD-4.0.0 1.2245E-05 None None None None N None 0 0 None 0 4.64317E-05 None 0 0 1.39591E-05 0 1.67448E-05
S/G 6862 Ig-53 9 rs772654281 0.0951 -0.332 0.201 N 0.291 0.13 0.143124449307 gnomAD-2.1.1 4.74E-05 None None None None I None 0 0 None 0 0 None 4.13099E-04 None 0 0 0
S/G 6862 Ig-53 9 rs772654281 0.0951 -0.332 0.201 N 0.291 0.13 0.143124449307 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
S/G 6862 Ig-53 9 rs772654281 0.0951 -0.332 0.201 N 0.291 0.13 0.143124449307 gnomAD-4.0.0 1.69431E-05 None None None None I None 0 0 None 0 0 None 0 0 0 2.96695E-04 1.62454E-05
S/N 6862 Ig-53 9 rs764794977 0.1025 0.131 0.001 N 0.123 0.054 0.0920862733494 gnomAD-2.1.1 4.26E-06 None None None None I None 0 0 None 0 5.67E-05 None 0 None 0 0 0
S/N 6862 Ig-53 9 rs764794977 0.1025 0.131 0.001 N 0.123 0.054 0.0920862733494 gnomAD-4.0.0 1.3851E-06 None None None None I None 0 0 None 0 5.06714E-05 None 0 0 0 0 0
S/T 6862 Ig-53 9 rs764794977 0.1006 0.054 0.334 N 0.269 0.079 0.126345400529 gnomAD-2.1.1 4.26E-06 None None None None I None 0 0 None 0 5.67E-05 None 0 None 0 0 0
S/T 6862 Ig-53 9 rs764794977 0.1006 0.054 0.334 N 0.269 0.079 0.126345400529 gnomAD-4.0.0 6.9255E-07 None None None None I None 0 0 None 0 2.53357E-05 None 0 0 0 0 0
P/L 6956 Ig-54 9 rs1054912076 0.1065 0.118 0.426 N 0.404 0.157 0.442977140156 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
P/L 6956 Ig-54 9 rs1054912076 0.1065 0.118 0.426 N 0.404 0.157 0.442977140156 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 6956 Ig-54 9 rs1054912076 0.1065 0.118 0.426 N 0.404 0.157 0.442977140156 gnomAD-4.0.0 1.87337E-06 None None None None N None 0 0 None 0 2.24507E-05 None 0 0 1.70738E-06 0 0
N/S 7052 Ig-55 9 rs1553913467 0.1056 None 0.001 N 0.167 0.068 0.0846915920261 gnomAD-4.0.0 1.59375E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86328E-06 0 0
P/S 7145 Ig-56 9 rs745988872 0.0962 -0.68 0.058 N 0.239 0.046 0.137902524267 gnomAD-2.1.1 4.3E-06 None None None None N None 0 3.14E-05 None 0 0 None 0 None 0 0 0
P/S 7145 Ig-56 9 rs745988872 0.0962 -0.68 0.058 N 0.239 0.046 0.137902524267 gnomAD-4.0.0 1.63743E-06 None None None None N None 0 2.44475E-05 None 0 0 None 0 0 0 0 0
D/E 7238 Ig-57 9 rs2078746720 0.3148 None 0.248 N 0.218 0.171 0.130388298395 gnomAD-4.0.0 1.3691E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79945E-06 0 0
D/H 7238 Ig-57 9 rs747881141 0.3944 None 0.998 N 0.529 0.346 0.201204373187 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 7238 Ig-57 9 rs747881141 0.3944 None 0.998 N 0.529 0.346 0.201204373187 gnomAD-4.0.0 6.57402E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47059E-05 0 0
D/N 7238 Ig-57 9 rs747881141 0.0928 -0.171 0.433 N 0.226 0.189 0.107399877778 gnomAD-2.1.1 1.44E-05 None None None None N None 8.29E-05 0 None 0 0 None 0 None 0 1.58E-05 0
D/N 7238 Ig-57 9 rs747881141 0.0928 -0.171 0.433 N 0.226 0.189 0.107399877778 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 7238 Ig-57 9 rs747881141 0.0928 -0.171 0.433 N 0.226 0.189 0.107399877778 gnomAD-4.0.0 6.20152E-06 None None None None N None 4.01134E-05 0 None 0 0 None 0 0 5.93591E-06 0 0
D/V 7238 Ig-57 9 rs780646514 0.456 0.077 0.994 N 0.606 0.317 0.471778926243 gnomAD-2.1.1 3.65E-05 None None None None N None 0 2.62238E-04 None 0 0 None 0 None 0 0 0
D/V 7238 Ig-57 9 rs780646514 0.456 0.077 0.994 N 0.606 0.317 0.471778926243 gnomAD-4.0.0 1.27536E-05 None None None None N None 0 1.83411E-04 None 0 0 None 0 0 0 0 0
P/H 7331 Ig-58 9 rs1301921042 0.1229 None 0.927 N 0.341 0.214 0.294918367191 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/H 7331 Ig-58 9 rs1301921042 0.1229 None 0.927 N 0.341 0.214 0.294918367191 gnomAD-4.0.0 6.57428E-06 None None None None N None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
P/L 7331 Ig-58 9 None 0.094 None 0.006 N 0.233 0.179 0.367612772649 gnomAD-4.0.0 6.84741E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16139E-05 0
P/T 7331 Ig-58 9 rs2078660887 0.0828 None 0.642 N 0.28 0.122 0.215869574891 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
P/T 7331 Ig-58 9 rs2078660887 0.0828 None 0.642 N 0.28 0.122 0.215869574891 gnomAD-4.0.0 6.57471E-06 None None None None N None 0 6.54965E-05 None 0 0 None 0 0 0 0 0
D/G 7427 Ig-59 9 rs749935348 0.3292 -0.614 0.93 N 0.444 0.553 0.386721274199 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/G 7427 Ig-59 9 rs749935348 0.3292 -0.614 0.93 N 0.444 0.553 0.386721274199 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 7427 Ig-59 9 rs749935348 0.3292 -0.614 0.93 N 0.444 0.553 0.386721274199 gnomAD-4.0.0 6.57289E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47046E-05 0 0
D/Y 7427 Ig-59 9 rs1292504636 0.6089 0.039 1.0 D 0.64 0.566 0.788010845958 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/Y 7427 Ig-59 9 rs1292504636 0.6089 0.039 1.0 D 0.64 0.566 0.788010845958 gnomAD-4.0.0 3.18722E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86241E-06 0 3.02957E-05
P/L 7710 Ig-62 9 None 0.0907 None 0.973 N 0.674 0.278 0.438913950225 gnomAD-4.0.0 6.88837E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02635E-07 0 0
P/S 7710 Ig-62 9 rs1157011296 0.0873 None 0.082 N 0.279 0.088 0.0954503805726 gnomAD-4.0.0 1.37752E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80514E-06 0 0
P/S 7897 Ig-64 9 rs1276562007 0.1233 None 0.852 N 0.456 0.21 0.107399877778 gnomAD-4.0.0 1.59651E-06 None None None None N None 0 0 None 0 2.77747E-05 None 0 0 0 0 0
D/E 7993 Ig-65 9 rs751011918 0.1356 -0.1 0.004 N 0.069 0.123 0.0954503805726 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/E 7993 Ig-65 9 rs751011918 0.1356 -0.1 0.004 N 0.069 0.123 0.0954503805726 gnomAD-4.0.0 1.36886E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31911E-05 0
D/G 7993 Ig-65 9 None 0.1303 None 0.379 N 0.301 0.235 0.168933306366 gnomAD-4.0.0 1.59251E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86189E-06 0 0
S/F 8086 Ig-66 9 rs754194524 0.188 -0.861 0.912 N 0.484 0.437 0.550589291799 gnomAD-2.1.1 7.29E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.6E-05 0
S/F 8086 Ig-66 9 rs754194524 0.188 -0.861 0.912 N 0.484 0.437 0.550589291799 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 8086 Ig-66 9 rs754194524 0.188 -0.861 0.912 N 0.484 0.437 0.550589291799 gnomAD-4.0.0 1.49063E-05 None None None None N None 1.33718E-05 0 None 0 0 None 0 0 1.61283E-05 0 6.41581E-05
D/N 8179 Ig-67 9 rs756975386 0.1185 -0.094 0.999 N 0.505 0.256 0.146414634003 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 8.92E-06 0
D/N 8179 Ig-67 9 rs756975386 0.1185 -0.094 0.999 N 0.505 0.256 0.146414634003 gnomAD-4.0.0 1.3695E-05 None None None None N None 0 0 None 0 2.52143E-05 None 0 0 1.71021E-05 0 0
H/L 8272 Ig-68 9 None 0.1173 None 0.085 N 0.223 0.279 0.434825671192 gnomAD-4.0.0 6.88821E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00341E-07 0 0
H/P 8272 Ig-68 9 rs1299797032 0.0593 0.423 None N 0.081 0.277 0.264081493735 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
H/P 8272 Ig-68 9 rs1299797032 0.0593 0.423 None N 0.081 0.277 0.264081493735 gnomAD-4.0.0 1.37764E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80068E-06 0 0
H/Q 8272 Ig-68 9 None 0.1327 None 0.519 N 0.251 0.131 0.115124310173 gnomAD-4.0.0 1.61603E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86627E-06 0 0
H/Y 8272 Ig-68 9 None 0.1151 None 0.899 N 0.313 0.247 0.302793454619 gnomAD-4.0.0 2.068E-06 None None None None N None 0 0 None 0 0 None 0 0 2.7024E-06 0 0
D/E 8368 Ig-69 9 rs369089044 0.3264 -0.066 0.992 N 0.365 0.241 0.0806252709748 gnomAD-2.1.1 3.29E-05 None None None None N None 6.57E-05 0 None 0 0 None 0 None 0 6.38E-05 0
D/E 8368 Ig-69 9 rs369089044 0.3264 -0.066 0.992 N 0.365 0.241 0.0806252709748 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
D/E 8368 Ig-69 9 rs369089044 0.3264 -0.066 0.992 N 0.365 0.241 0.0806252709748 gnomAD-4.0.0 3.79157E-05 None None None None N None 0 0 None 0 0 None 0 0 4.92553E-05 0 4.82129E-05
P/T 8557 Ig-71 9 None 0.0976 None 0.001 N 0.283 0.047 0.126345400529 gnomAD-4.0.0 1.65379E-06 None None None None N None 0 0 None 0 0 None 0 0 2.96969E-06 0 0
P/L 8651 Ig-72 9 rs368758220 0.0892 0.138 0.003 N 0.307 0.195 None gnomAD-2.1.1 4.1E-06 None None None None I None 6.5E-05 0 None 0 0 None 0 None 0 0 0
P/L 8651 Ig-72 9 rs368758220 0.0892 0.138 0.003 N 0.307 0.195 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/L 8651 Ig-72 9 rs368758220 0.0892 0.138 0.003 N 0.307 0.195 None gnomAD-4.0.0 2.58533E-06 None None None None I None 3.41087E-05 0 None 0 0 None 0 0 0 0 0
D/G 8744 Ig-73 9 rs189391840 0.1536 -0.078 0.001 N 0.187 0.319 None gnomAD-2.1.1 2.03E-05 None None None None I None 0 0 None 0 2.80238E-04 None 0 None 0 0 0
D/G 8744 Ig-73 9 rs189391840 0.1536 -0.078 0.001 N 0.187 0.319 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 7.7101E-04 None 0 0 0 0 0
D/G 8744 Ig-73 9 rs189391840 0.1536 -0.078 0.001 N 0.187 0.319 None 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 3E-03 0 None None None 0 None
D/G 8744 Ig-73 9 rs189391840 0.1536 -0.078 0.001 N 0.187 0.319 None gnomAD-4.0.0 4.97728E-06 None None None None I None 0 0 None 0 1.78827E-04 None 0 0 0 0 0
E/K 8934 Ig-75 9 rs2076941615 0.0992 None 0.822 N 0.471 0.208 0.227260227426 gnomAD-4.0.0 1.7432E-06 None None None None N None 0 2.8082E-05 None 0 0 None 0 0 0 0 0
P/L 9027 Ig-76 9 rs1356270449 0.1293 None None N 0.276 0.204 0.386395597597 gnomAD-4.0.0 9.58509E-06 None None None None N None 0 0 None 0 0 None 0 0 1.25977E-05 0 0
P/T 9027 Ig-76 9 rs2154296309 0.0898 None 0.012 N 0.339 0.032 0.0401082797425 gnomAD-4.0.0 1.36931E-06 None None None None N None 0 0 None 0 5.04388E-05 None 0 0 0 0 0
D/Y 9120 Ig-77 9 None 0.3997 None 0.999 N 0.651 0.38 0.574978667741 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 9213 Ig-78 9 rs747751433 0.1424 0.006 1.0 N 0.681 0.365 0.436132833422 gnomAD-2.1.1 2.15E-05 None None None None I None 4.14E-05 5.67E-05 None 0 0 None 3.28E-05 None 0 1.57E-05 0
P/L 9213 Ig-78 9 rs747751433 0.1424 0.006 1.0 N 0.681 0.365 0.436132833422 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/L 9213 Ig-78 9 rs747751433 0.1424 0.006 1.0 N 0.681 0.365 0.436132833422 gnomAD-4.0.0 1.05374E-05 None None None None I None 4.00684E-05 3.33645E-05 None 0 0 None 0 0 6.78193E-06 2.19713E-05 3.20266E-05
P/T 9213 Ig-78 9 None 0.1018 None 0.999 N 0.679 0.327 0.277317399466 gnomAD-4.0.0 6.8436E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99638E-07 0 0
E/D 9501 Ig-81 9 None 0.1786 None 0.996 None 0.445 0.125 0.204665344411 gnomAD-4.0.0 6.84502E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99609E-07 0 0
P/S 9598 Ig-82 9 None 0.1048 None 0.001 None 0.302 0.127 0.148003135375 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 9706 Ig-83 9 None 0.2228 None 0.023 None 0.139 0.051 0.110078149338 gnomAD-4.0.0 1.59501E-06 None None None None N None 0 0 None 0 0 None 0 2.41313E-04 0 0 0
N/S 9908 Ig-84 9 None 0.3923 None 0.334 None 0.385 0.168 0.128392430309 gnomAD-4.0.0 1.59983E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8608E-06 0 0
D/N 9997 Ig-85 9 rs1287288966 0.198 0.008 1.0 None 0.617 0.315 0.166414681773 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
D/N 9997 Ig-85 9 rs1287288966 0.198 0.008 1.0 None 0.617 0.315 0.166414681773 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 9997 Ig-85 9 rs1287288966 0.198 0.008 1.0 None 0.617 0.315 0.166414681773 gnomAD-4.0.0 3.8442E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18222E-06 0 0
D/V 9997 Ig-85 9 rs1211337787 0.7727 0.274 1.0 None 0.765 0.376 0.50143340055 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
N/D 10086 Ig-86 9 rs1188623443 0.6484 0.208 0.98 None 0.421 0.34 0.250579442822 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65344E-04
N/D 10086 Ig-86 9 rs1188623443 0.6484 0.208 0.98 None 0.421 0.34 0.250579442822 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02352E-05
N/K 10086 Ig-86 9 rs2075205547 0.9863 None 0.98 None 0.423 0.377 0.307016933798 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85753E-06 0 0
D/G 13691 Ig-87 8 None 0.9452 None 1.0 D 0.787 0.711 0.543910352347 gnomAD-4.0.0 1.59225E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85992E-06 0 0
D/G 13973 Ig-90 9 None 0.8659 None 0.015 N 0.322 0.222 0.159798565429 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 13973 Ig-90 9 None 0.4387 None 0.919 N 0.541 0.193 0.167679373172 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/A 14062 Ig-91 9 rs1282444173 0.7867 -0.04 1.0 D 0.801 0.527 0.372446077551 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
D/A 14062 Ig-91 9 rs1282444173 0.7867 -0.04 1.0 D 0.801 0.527 0.372446077551 gnomAD-4.0.0 6.84392E-07 None None None None N None 0 0 None 0 2.52143E-05 None 0 0 0 0 0
D/E 14062 Ig-91 9 None 0.6811 None 1.0 D 0.429 0.351 0.249502417897 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8602E-06 0 0
D/G 14062 Ig-91 9 None 0.7768 None 1.0 D 0.779 0.558 0.337868961071 gnomAD-4.0.0 1.36878E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79932E-06 0 0
D/N 14150 Ig-92 9 rs1184338421 0.1492 -0.188 1.0 N 0.693 0.348 0.330331372229 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/N 14150 Ig-92 9 rs1184338421 0.1492 -0.188 1.0 N 0.693 0.348 0.330331372229 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
D/N 14239 Ig-93 9 rs1050740085 0.1373 None 1.0 N 0.611 0.305 0.239305524855 gnomAD-4.0.0 8.40225E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
G/R 14327 Ig-94 9 rs375403946 0.6109 -0.216 1.0 N 0.791 0.422 0.481988042695 gnomAD-2.1.1 4.29E-05 None None None None N None 0 0 None 0 3.60193E-04 None 6.55E-05 None 0 1.57E-05 1.40687E-04
G/R 14327 Ig-94 9 rs375403946 0.6109 -0.216 1.0 N 0.791 0.422 0.481988042695 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 6.55E-05 0 0 1.93573E-04 None 0 0 0 0 0
G/R 14327 Ig-94 9 rs375403946 0.6109 -0.216 1.0 N 0.791 0.422 0.481988042695 gnomAD-4.0.0 3.53355E-05 None None None None N None 2.66795E-05 1.66811E-05 None 0 2.0092E-04 None 0 0 3.22187E-05 6.5966E-05 1.60128E-05
D/V 14416 Ig-95 9 None 0.832 None 1.0 D 0.7 0.723 0.786937795147 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 14505 Ig-96 9 None 0.7478 None 1.0 D 0.449 0.608 0.552940642338 gnomAD-4.0.0 6.90376E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04395E-07 0 0
D/H 14505 Ig-96 9 rs1479425024 0.8987 None 1.0 D 0.721 0.552 0.668570387503 gnomAD-2.1.1 4.36E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.64E-06 0
D/H 14505 Ig-96 9 rs1479425024 0.8987 None 1.0 D 0.721 0.552 0.668570387503 gnomAD-4.0.0 1.62926E-06 None None None None N None 0 0 None 0 0 None 0 0 2.91404E-06 0 0
D/G 14594 Ig-97 9 None 0.2999 None 0.996 D 0.511 0.492 0.210429274316 gnomAD-4.0.0 3.19667E-06 None None None None N None 0 4.59179E-05 None 0 0 None 0 0 0 0 0
S/G 14683 Ig-98 9 None 0.3036 None 0.997 N 0.639 0.296 0.126345400529 gnomAD-4.0.0 1.59433E-06 None None None None N None 0 0 None 0 2.7835E-05 None 0 0 0 0 0
D/H 14772 Ig-99 8 rs1426162588 0.885 None 1.0 D 0.706 0.469 0.260735089382 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 14772 Ig-99 8 rs1426162588 0.885 None 1.0 D 0.706 0.469 0.260735089382 gnomAD-4.0.0 1.24002E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69589E-06 0 0
D/Y 14772 Ig-99 8 rs1426162588 0.8371 0.179 1.0 D 0.769 0.45 0.566629817802 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/Y 14772 Ig-99 8 rs1426162588 0.8371 0.179 1.0 D 0.769 0.45 0.566629817802 gnomAD-4.0.0 2.05365E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47955E-05 0
D/N 14861 Ig-100 9 rs1044788441 0.3294 0.39 1.0 N 0.635 0.433 0.459370960843 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
D/N 14861 Ig-100 9 rs1044788441 0.3294 0.39 1.0 N 0.635 0.433 0.459370960843 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/N 14861 Ig-100 9 rs1044788441 0.3294 0.39 1.0 N 0.635 0.433 0.459370960843 gnomAD-4.0.0 1.11648E-05 None None None None N None 0 0 None 0 0 None 0 0 1.18748E-05 0 6.41375E-05
D/E 14950 Ig-101 9 rs371376631 0.5956 0.076 0.992 D 0.402 0.271 0.224531998449 gnomAD-2.1.1 1.26E-05 None None None None N None 0 0 None 0 0 None 1.04588E-04 None 0 0 0
D/E 14950 Ig-101 9 rs371376631 0.5956 0.076 0.992 D 0.402 0.271 0.224531998449 gnomAD-4.0.0 2.06356E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.54845E-05 0
D/G 14950 Ig-101 9 rs1194581912 0.5617 0.027 0.992 D 0.6 0.406 0.299770980665 gnomAD-2.1.1 4.19E-06 None None None None N None 0 0 None 0 0 None 0 None 4.73E-05 0 0
D/G 14950 Ig-101 9 rs1194581912 0.5617 0.027 0.992 D 0.6 0.406 0.299770980665 gnomAD-4.0.0 1.61074E-06 None None None None N None 0 0 None 0 0 None 1.89459E-05 0 0 0 0
D/H 14950 Ig-101 9 rs571524382 0.7256 None 1.0 D 0.653 0.389 None gnomAD-3.1.2 6.6E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
D/H 14950 Ig-101 9 rs571524382 0.7256 None 1.0 D 0.653 0.389 None gnomAD-4.0.0 1.2461E-06 None None None None N None 2.68248E-05 0 None 0 0 None 0 0 0 0 0
D/N 14950 Ig-101 9 rs571524382 0.2279 0.493 0.999 N 0.619 0.36 0.267755039894 gnomAD-2.1.1 2.6E-05 None None None None N None 8.69E-05 0 None 0 5.33E-05 None 0 None 0 3.24E-05 0
D/N 14950 Ig-101 9 rs571524382 0.2279 0.493 0.999 N 0.619 0.36 0.267755039894 gnomAD-3.1.2 6.6E-05 None None None None N None 1.45229E-04 0 0 0 1.95084E-04 None 0 0 4.42E-05 0 0
D/N 14950 Ig-101 9 rs571524382 0.2279 0.493 0.999 N 0.619 0.36 0.267755039894 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
D/N 14950 Ig-101 9 rs571524382 0.2279 0.493 0.999 N 0.619 0.36 0.267755039894 gnomAD-4.0.0 2.24281E-05 None None None None N None 1.47295E-04 0 None 0 4.50714E-05 None 0 0 1.95613E-05 0 0
N/D 15039 Ig-102 9 None 0.0866 None 0.046 N 0.204 0.304 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 15039 Ig-102 9 rs758487494 0.4866 0.356 0.939 D 0.434 0.547 0.329282125956 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
N/K 15039 Ig-102 9 rs758487494 0.4866 0.356 0.939 D 0.434 0.547 0.329282125956 gnomAD-4.0.0 1.59571E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43554E-05 0
D/E 15399 Ig-106 9 rs1332002805 0.9157 -0.248 1.0 D 0.442 0.625 0.494031935134 gnomAD-2.1.1 4.28E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.37E-06 0
D/E 15399 Ig-106 9 rs1332002805 0.9157 -0.248 1.0 D 0.442 0.625 0.494031935134 gnomAD-4.0.0 1.65094E-06 None None None None N None 0 0 None 0 0 None 0 0 2.96356E-06 0 0
D/G 15399 Ig-106 9 None 0.9467 None 1.0 D 0.692 0.772 0.634824181903 gnomAD-4.0.0 1.64878E-06 None None None None N None 0 0 None 0 0 None 0 0 2.95961E-06 0 0
G/V 15971 Ig-109 4 None 0.7042 None 1.0 D 0.783 0.508 0.59734385502 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/D 16267 Ig-110 6 rs917290755 0.9533 -0.517 1.0 N 0.792 0.457 0.234412748748 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
G/D 16267 Ig-110 6 rs917290755 0.9533 -0.517 1.0 N 0.792 0.457 0.234412748748 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 16267 Ig-110 6 rs917290755 0.9533 -0.517 1.0 N 0.792 0.457 0.234412748748 gnomAD-4.0.0 6.58432E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47228E-05 0 0
G/V 16267 Ig-110 6 None 0.9501 None 1.0 N 0.815 0.484 0.43965937752 gnomAD-4.0.0 1.59677E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86609E-06 0 0
D/E 16963 Ig-111 9 None 0.3327 None 1.0 N 0.406 0.246 0.19670166235 gnomAD-4.0.0 2.05424E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69964E-06 0 0
D/N 16963 Ig-111 9 rs760115243 0.1442 -0.592 1.0 N 0.617 0.362 0.259761712551 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/N 16963 Ig-111 9 rs760115243 0.1442 -0.592 1.0 N 0.617 0.362 0.259761712551 gnomAD-4.0.0 1.36954E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.32089E-05 0
D/V 16963 Ig-111 9 rs775055815 0.605 0.257 1.0 D 0.693 0.591 0.411133732114 gnomAD-2.1.1 4.04E-05 None None None None I None 0 0 None 0 0 None 3.27354E-04 None 0 0 0
D/V 16963 Ig-111 9 rs775055815 0.605 0.257 1.0 D 0.693 0.591 0.411133732114 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 0 4.14422E-04 0
D/V 16963 Ig-111 9 rs775055815 0.605 0.257 1.0 D 0.693 0.591 0.411133732114 gnomAD-4.0.0 1.30245E-05 None None None None I None 0 0 None 0 0 None 0 0 0 2.30713E-04 0
D/Y 16963 Ig-111 9 rs760115243 0.5534 -0.064 1.0 D 0.645 0.538 0.396794106654 gnomAD-2.1.1 4.05E-05 None None None None I None 0 0 None 0 0 None 3.27354E-04 None 0 0 0
D/Y 16963 Ig-111 9 rs760115243 0.5534 -0.064 1.0 D 0.645 0.538 0.396794106654 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 0 4.14766E-04 0
D/Y 16963 Ig-111 9 rs760115243 0.5534 -0.064 1.0 D 0.645 0.538 0.396794106654 gnomAD-4.0.0 1.36453E-05 None None None None I None 0 0 None 0 0 None 0 0 0 2.30784E-04 1.60339E-05
S/R 17256 Ig-112 6 rs794729454 0.5725 None 0.782 N 0.689 0.225 0.181679512989 gnomAD-4.0.0 2.40064E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
G/R 17681 Ig-113 5 rs2055221235 0.6617 None 1.0 N 0.764 0.434 0.797513714255 gnomAD-4.0.0 1.36901E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79949E-06 0 0
T/A 17975 Ig-114 8 None 0.0999 None 0.704 N 0.303 0.089 0.126345400529 gnomAD-4.0.0 6.87803E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02291E-07 0 0
T/I 17975 Ig-114 8 None 0.1879 None 0.852 N 0.331 0.136 0.233785782151 gnomAD-4.0.0 6.87773E-07 None None None None N None 0 0 None 0 2.54181E-05 None 0 0 0 0 0
T/S 17975 Ig-114 8 rs727503605 0.1423 -0.635 0.159 N 0.079 0.103 0.107399877778 gnomAD-2.1.1 4.58E-05 None None None None N None 0 0 None 0 0 None 3.7471E-04 None 0 0 0
T/S 17975 Ig-114 8 rs727503605 0.1423 -0.635 0.159 N 0.079 0.103 0.107399877778 gnomAD-4.0.0 1.92576E-05 None None None None N None 0 0 None 0 0 None 0 0 0 3.28477E-04 0
C/S 18387 Ig-115 6 None 0.132 None None N 0.331 0.15 0.266843984389 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/L 18693 Ig-116 6 rs1458763630 0.8998 -0.231 0.826 N 0.439 0.137 0.270889551736 gnomAD-2.1.1 4.25E-06 None None None None N None 0 0 None 0 0 None 3.64E-05 None 0 0 0
F/L 18693 Ig-116 6 rs1458763630 0.8998 -0.231 0.826 N 0.439 0.137 0.270889551736 gnomAD-4.0.0 1.63184E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.50024E-05 0
R/G 19101 Ig-117 7 rs763313986 0.5976 -0.381 0.959 N 0.447 0.327 0.230578612272 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/G 19101 Ig-117 7 rs763313986 0.5976 -0.381 0.959 N 0.447 0.327 0.230578612272 gnomAD-4.0.0 1.59258E-06 None None None None I None 5.66123E-05 0 None 0 0 None 0 0 0 0 0
R/S 19101 Ig-117 7 None 0.816 None 0.92 N 0.431 0.223 0.250039746154 gnomAD-4.0.0 1.59256E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85992E-06 0 0
K/E 19395 Ig-118 5 None 0.1763 None 0.822 N 0.481 0.372 0.390060412749 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 19395 Ig-118 5 None 0.2981 None 0.942 N 0.467 0.235 0.282179105231 gnomAD-4.0.0 6.84404E-07 None None None None N None 0 0 None 3.8279E-05 0 None 0 0 0 0 0
K/R 19395 Ig-118 5 None 0.0865 None 0.032 D 0.329 0.109 0.399740851666 gnomAD-4.0.0 7.52852E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89541E-06 0 0
K/T 19395 Ig-118 5 rs1200343273 0.1045 0.202 0.698 N 0.481 0.31 0.362361684037 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.73E-05 None 0 0 None 0 None 0 0 0
K/T 19395 Ig-118 5 rs1200343273 0.1045 0.202 0.698 N 0.481 0.31 0.362361684037 gnomAD-4.0.0 2.05323E-06 None None None None N None 0 6.71682E-05 None 0 0 None 0 0 0 0 0
E/G 19795 Ig-119 6 rs776032119 0.4905 -1.262 1.0 N 0.744 0.449 0.301455362545 gnomAD-2.1.1 7.16E-06 None None None None N None 0 0 None 0 1.03348E-04 None 0 None 0 0 0
E/G 19795 Ig-119 6 rs776032119 0.4905 -1.262 1.0 N 0.744 0.449 0.301455362545 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93949E-04 None 0 0 0 0 0
E/G 19795 Ig-119 6 rs776032119 0.4905 -1.262 1.0 N 0.744 0.449 0.301455362545 gnomAD-4.0.0 2.56374E-06 None None None None N None 0 0 None 0 4.86594E-05 None 0 0 0 0 0
E/K 19795 Ig-119 6 None 0.6423 None 0.999 N 0.613 0.379 0.283761946502 gnomAD-4.0.0 1.59241E-06 None None None None N None 0 0 None 4.76917E-05 0 None 0 0 0 0 0
G/D 20087 Ig-120 8 None 0.8015 None 1.0 N 0.836 0.462 0.258283824007 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/S 20087 Ig-120 8 rs761836336 0.4887 -0.594 1.0 N 0.716 0.444 0.235038932564 gnomAD-2.1.1 4.46E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.46E-06 0
G/V 20087 Ig-120 8 None 0.8097 None 1.0 N 0.859 0.468 0.461759001683 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/F 20778 Ig-122 10 rs754672686 0.1855 -0.906 0.966 D 0.488 0.276 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
V/F 20778 Ig-122 10 rs754672686 0.1855 -0.906 0.966 D 0.488 0.276 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/F 20778 Ig-122 10 rs754672686 0.1855 -0.906 0.966 D 0.488 0.276 None gnomAD-4.0.0 1.23972E-06 None None None None N None 1.33561E-05 0 None 0 0 None 1.5626E-05 0 0 0 0
V/I 20778 Ig-122 10 None 0.0708 None 0.625 D 0.445 0.108 0.588051273532 gnomAD-4.0.0 6.84334E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99551E-07 0 0
T/I 22270 Ig-126 6 rs2047465405 0.2648 None 0.166 N 0.323 0.107 0.233150807113 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 22270 Ig-126 6 rs2047465405 0.2648 None 0.166 N 0.323 0.107 0.233150807113 gnomAD-4.0.0 6.57514E-06 None None None None I None 2.41278E-05 0 None 0 0 None 0 0 0 0 0
G/A 22955 Ig-128 6 rs201381085 0.2034 -0.364 0.999 N 0.563 0.264 None gnomAD-2.1.1 2.62379E-04 None None None None N None 4.14E-05 4.28449E-04 None 0 0 None 0 None 0 4.04204E-04 7.14694E-04
G/A 22955 Ig-128 6 rs201381085 0.2034 -0.364 0.999 N 0.563 0.264 None gnomAD-3.1.2 3.16222E-04 None None None None N None 9.69E-05 5.9156E-04 0 0 0 None 0 0 5.15054E-04 0 0
G/A 22955 Ig-128 6 rs201381085 0.2034 -0.364 0.999 N 0.563 0.264 None gnomAD-4.0.0 2.73163E-04 None None None None N None 5.3749E-05 5.37382E-04 None 0 0 None 1.63854E-05 3.31345E-04 3.35446E-04 0 8.10163E-05
T/I 23353 Ig-129 9 rs1709976943 0.4456 None 0.994 N 0.662 0.38 0.299427821978 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 23353 Ig-129 9 rs1709976943 0.4456 None 0.994 N 0.662 0.38 0.299427821978 gnomAD-4.0.0 6.57678E-06 None None None None N None 2.41383E-05 0 None 0 0 None 0 0 0 0 0
T/M 24038 Ig-131 10 rs370375696 0.0852 -0.088 0.973 N 0.389 0.258 None gnomAD-2.1.1 1.35913E-03 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 1.20962E-02 None 4E-05 2.35E-05 4.22178E-04
T/M 24038 Ig-131 10 rs370375696 0.0852 -0.088 0.973 N 0.389 0.258 None gnomAD-3.1.2 3.09231E-04 None None None None N None 7.25E-05 0 0 0 0 None 1.88857E-04 0 2.94E-05 8.28157E-03 0
T/M 24038 Ig-131 10 rs370375696 0.0852 -0.088 0.973 N 0.389 0.258 None 1000 genomes 1.99681E-03 None None None None N None 0 0 None None 0 0 None None None 1.02E-02 None
T/M 24038 Ig-131 10 rs370375696 0.0852 -0.088 0.973 N 0.389 0.258 None gnomAD-4.0.0 6.6572E-04 None None None None N None 4.00203E-05 1.66744E-05 None 0 2.23764E-05 None 3.12588E-05 0 1.78028E-05 1.0992E-02 7.20369E-04
V/A 24437 Ig-132 7 None 0.1761 None 0.999 N 0.6 0.16 0.544738774389 gnomAD-4.0.0 6.84341E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15955E-05 0
V/D 24437 Ig-132 7 None 0.6762 None 1.0 N 0.747 0.401 0.818452415539 gnomAD-4.0.0 1.36868E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79921E-06 0 0
T/A 24724 Ig-133 9 None 0.1379 None 0.919 N 0.393 0.281 0.239901079897 gnomAD-4.0.0 1.59237E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85953E-06 0 0
T/I 24724 Ig-133 9 rs528199512 0.3147 -0.073 0.919 N 0.591 0.435 0.33340067248 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 9.41E-05 0 0 0 0
T/I 24724 Ig-133 9 rs528199512 0.3147 -0.073 0.919 N 0.591 0.435 0.33340067248 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
T/I 24724 Ig-133 9 rs528199512 0.3147 -0.073 0.919 N 0.591 0.435 0.33340067248 gnomAD-4.0.0 6.56849E-06 None None None None I None 0 0 None 0 0 None 9.41442E-05 0 0 0 0
I/N 25519 Ig-135 6 rs376185524 0.1519 None 0.055 N 0.459 0.217 0.627368885312 gnomAD-4.0.0 2.05366E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69906E-06 0 0
I/T 25519 Ig-135 6 rs376185524 0.1427 -0.866 0.012 N 0.443 0.153 None gnomAD-2.1.1 4.86E-05 None None None None I None 0 1.16496E-04 None 0 0 None 3.28E-05 None 0 5.37E-05 1.6728E-04
I/T 25519 Ig-135 6 rs376185524 0.1427 -0.866 0.012 N 0.443 0.153 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 25519 Ig-135 6 rs376185524 0.1427 -0.866 0.012 N 0.443 0.153 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
I/T 25519 Ig-135 6 rs376185524 0.1427 -0.866 0.012 N 0.443 0.153 None gnomAD-4.0.0 2.41808E-05 None None None None I None 0 6.67802E-05 None 0 0 None 0 1.65289E-04 2.62835E-05 1.09888E-05 3.2039E-05
S/N 25806 Ig-136 9 rs1405741278 0.0881 None None N 0.088 0.085 0.0401082797425 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
S/N 25806 Ig-136 9 rs1405741278 0.0881 None None N 0.088 0.085 0.0401082797425 gnomAD-4.0.0 2.47957E-06 None None None None N None 2.67087E-05 0 None 0 0 None 0 0 8.47779E-07 0 1.60159E-05
S/R 25806 Ig-136 9 rs759686148 0.4322 0.027 0.317 N 0.366 0.182 0.207176502487 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 26202 Ig-137 10 None 0.14 None 0.028 N 0.201 0.059 0.229924730088 gnomAD-4.0.0 3.42548E-06 None None None None N None 2.99509E-05 0 None 0 0 None 0 0 3.60015E-06 0 0
T/P 26202 Ig-137 10 rs1364192252 0.3385 -0.187 0.979 N 0.413 0.233 0.266843984389 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
T/P 26202 Ig-137 10 rs1364192252 0.3385 -0.187 0.979 N 0.413 0.233 0.266843984389 gnomAD-4.0.0 2.05572E-06 None None None None N None 2.99527E-05 0 None 0 0 None 0 1.74034E-04 0 1.16675E-05 0
G/A 26601 Ig-138 8 None 0.262 None 0.991 N 0.539 0.376 0.268211541103 gnomAD-4.0.0 3.18326E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71765E-06 0 0
G/R 26601 Ig-138 8 rs773632027 0.9004 -0.268 0.997 N 0.775 0.452 0.476051820916 gnomAD-2.1.1 1.61E-05 None None None None I None 0 1.15922E-04 None 0 0 None 0 None 0 0 0
G/R 26601 Ig-138 8 rs773632027 0.9004 -0.268 0.997 N 0.775 0.452 0.476051820916 gnomAD-4.0.0 6.36661E-06 None None None None I None 0 9.14662E-05 None 0 0 None 0 0 0 0 0
T/I 26888 Ig-139 9 None 0.2274 None 0.997 N 0.705 0.389 0.312306559268 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
V/I 27284 Ig-140 7 rs746222222 0.0729 0.011 0.201 N 0.488 0.065 0.296679040009 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/I 27284 Ig-140 7 rs746222222 0.0729 0.011 0.201 N 0.488 0.065 0.296679040009 gnomAD-4.0.0 1.92153E-05 None None None None N None 0 0 None 0 2.22955E-05 None 0 0 2.37334E-05 0 3.20246E-05
V/G 27684 Ig-141 9 None 0.3294 None 0.684 N 0.489 0.278 0.766809873248 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/L 27684 Ig-141 9 rs779966248 0.3165 -0.272 0.003 N 0.091 0.052 0.558342666981 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 27971 Ig-142 9 rs749273430 0.2153 0.138 0.978 N 0.587 0.406 0.339316883193 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
T/I 27971 Ig-142 9 rs749273430 0.2153 0.138 0.978 N 0.587 0.406 0.339316883193 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 27971 Ig-142 9 rs749273430 0.2153 0.138 0.978 N 0.587 0.406 0.339316883193 gnomAD-4.0.0 5.58137E-06 None None None None I None 0 0 None 0 2.23464E-05 None 0 0 6.78325E-06 0 0
T/S 27971 Ig-142 9 rs956060755 0.1413 0.148 0.865 N 0.433 0.162 0.134241683229 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
T/S 27971 Ig-142 9 rs956060755 0.1413 0.148 0.865 N 0.433 0.162 0.134241683229 gnomAD-4.0.0 6.8476E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99802E-07 0 0
V/A 28366 Ig-143 9 rs1003730939 0.1889 None 0.09 N 0.341 0.077 0.273938319068 gnomAD-4.0.0 1.59109E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85802E-06 0 0
V/I 28366 Ig-143 9 rs367800789 0.0794 -0.345 0.008 N 0.21 0.044 None gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 1.39276E-04 3.56E-05 0
V/I 28366 Ig-143 9 rs367800789 0.0794 -0.345 0.008 N 0.21 0.044 None gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 2.07469E-04 0
V/I 28366 Ig-143 9 rs367800789 0.0794 -0.345 0.008 N 0.21 0.044 None gnomAD-4.0.0 3.65613E-05 None None None None I None 1.33486E-05 0 None 0 0 None 1.71832E-04 0 3.13611E-05 9.88186E-05 1.60097E-05
T/I 29053 Ig-145 9 rs573319412 0.2077 0.036 0.998 N 0.715 0.344 0.334659703779 gnomAD-2.1.1 8.58E-05 None None None None N None 0 0 None 0 9.56992E-04 None 0 None 0 3.6E-05 0
T/I 29053 Ig-145 9 rs573319412 0.2077 0.036 0.998 N 0.715 0.344 0.334659703779 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 4.41E-05 0 0
T/I 29053 Ig-145 9 rs573319412 0.2077 0.036 0.998 N 0.715 0.344 0.334659703779 gnomAD-4.0.0 2.29715E-05 None None None None N None 0 0 None 0 3.56904E-04 None 0 0 1.69599E-05 0 1.60328E-05
V/F 29449 Ig-146 6 None 0.2287 None 0.97 N 0.471 0.321 0.518641613453 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
S/T 29848 Ig-147 7 None 0.0856 None 0.98 N 0.421 0.176 0.132336055621 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
G/D 30535 Ig-149 4 rs374896493 0.2815 -0.459 1.0 N 0.743 0.324 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
G/D 30535 Ig-149 4 rs374896493 0.2815 -0.459 1.0 N 0.743 0.324 None gnomAD-4.0.0 3.18528E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72125E-06 0 0
G/S 30535 Ig-149 4 None 0.1111 None 1.0 N 0.724 0.316 0.202949470691 gnomAD-4.0.0 3.18505E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72079E-06 0 0
G/V 30535 Ig-149 4 rs374896493 0.2639 0.033 1.0 N 0.756 0.332 0.576407682716 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
G/V 30535 Ig-149 4 rs374896493 0.2639 0.033 1.0 N 0.756 0.332 0.576407682716 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/V 30535 Ig-149 4 rs374896493 0.2639 0.033 1.0 N 0.756 0.332 0.576407682716 gnomAD-4.0.0 1.31553E-05 None None None None N None 0 0 None 0 0 None 0 0 2.93988E-05 0 0
T/A 30934 Ig-150 8 None 0.1426 None 0.865 N 0.411 0.194 0.143124449307 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 30934 Ig-150 8 rs774501308 0.1835 -0.424 0.957 N 0.612 0.303 0.325533332567 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65782E-04
T/I 30934 Ig-150 8 rs774501308 0.1835 -0.424 0.957 N 0.612 0.303 0.325533332567 gnomAD-4.0.0 1.36928E-06 None None None None N None 0 0 None 0 2.52092E-05 None 1.906E-05 0 0 0 0
T/I 32023 Ig-153 7 None 0.2122 None 0.014 N 0.279 0.161 0.198526703765 gnomAD-4.0.0 6.84646E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9996E-07 0 0
T/S 32023 Ig-153 7 rs1030758412 0.212 None 0.904 N 0.379 0.201 0.101711395817 gnomAD-4.0.0 2.05394E-06 None None None None N None 0 2.23874E-05 None 0 0 None 0 0 8.9996E-07 1.16004E-05 0
T/A 32315 Ig-154 9 rs1363712214 0.1329 -0.569 0.826 N 0.288 0.081 0.152612264143 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/A 32315 Ig-154 9 rs1363712214 0.1329 -0.569 0.826 N 0.288 0.081 0.152612264143 gnomAD-4.0.0 1.5955E-06 None None None None N None 0 2.28822E-05 None 0 0 None 0 0 0 0 0
T/I 32315 Ig-154 9 rs56027402 0.1646 0.33 0.061 N 0.173 0.126 None gnomAD-2.1.1 6.00651E-03 None None None None N None 6.4336E-02 2.40698E-03 None 0 0 None 2.29223E-04 None 0 1.33894E-04 1.5493E-03
T/I 32315 Ig-154 9 rs56027402 0.1646 0.33 0.061 N 0.173 0.126 None gnomAD-3.1.2 1.79995E-02 None None None None N None 6.32037E-02 4.9823E-03 0 0 0 None 0 3.16456E-03 2.49934E-04 6.21375E-04 1.14833E-02
T/I 32315 Ig-154 9 rs56027402 0.1646 0.33 0.061 N 0.173 0.126 None 1000 genomes 1.63738E-02 None None None None N None 5.75E-02 8.6E-03 None None 0 0 None None None 0 None
T/I 32315 Ig-154 9 rs56027402 0.1646 0.33 0.061 N 0.173 0.126 None gnomAD-4.0.0 3.40756E-03 None None None None N None 6.51298E-02 3.36902E-03 None 0 0 None 0 1.81758E-03 7.46826E-05 2.1979E-04 4.64476E-03
T/N 32315 Ig-154 9 rs56027402 0.2023 None 0.996 N 0.314 0.234 0.282179105231 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
T/N 32315 Ig-154 9 rs56027402 0.2023 None 0.996 N 0.314 0.234 0.282179105231 gnomAD-4.0.0 3.72233E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.49451E-05 1.6022E-05
T/S 32315 Ig-154 9 None 0.192 None 0.959 N 0.298 0.12 0.143124449307 gnomAD-4.0.0 1.5955E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02847E-05
G/D 32713 Ig-155 6 rs1374598528 0.3517 None 1.0 N 0.734 0.338 0.239305524855 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
G/D 32713 Ig-155 6 rs1374598528 0.3517 None 1.0 N 0.734 0.338 0.239305524855 gnomAD-4.0.0 1.23953E-06 None None None None I None 1.33572E-05 0 None 0 0 None 0 0 8.47657E-07 0 0
G/S 32713 Ig-155 6 None 0.1506 None 1.0 N 0.697 0.301 0.216624796971 gnomAD-4.0.0 1.36853E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
G/V 32713 Ig-155 6 None 0.2124 None 1.0 N 0.783 0.353 0.621426341079 gnomAD-4.0.0 6.84246E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99507E-07 0 0
D/G 33109 Ig-156 9 rs1481058510 0.3775 -0.997 1.0 N 0.687 0.551 0.298403945805 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/G 33109 Ig-156 9 rs1481058510 0.3775 -0.997 1.0 N 0.687 0.551 0.298403945805 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 33109 Ig-156 9 rs1481058510 0.3775 -0.997 1.0 N 0.687 0.551 0.298403945805 gnomAD-4.0.0 6.57047E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46972E-05 0 0
D/N 33109 Ig-156 9 None 0.191 None 1.0 N 0.583 0.394 0.275215494804 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 33604 Ig-159 9 None 0.2387 None 1.0 N 0.68 0.308 0.425499470309 gnomAD-4.0.0 1.37344E-06 None None None None N None 0 0 None 0 0 None 1.92478E-05 0 0 0 1.6619E-05
A/V 33604 Ig-159 9 rs1691172442 0.3714 None 1.0 N 0.608 0.33 0.481393932785 gnomAD-3.1.2 6.62E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 33604 Ig-159 9 rs1691172442 0.3714 None 1.0 N 0.608 0.33 0.481393932785 gnomAD-4.0.0 2.48809E-06 None None None None N None 0 0 None 0 0 None 0 0 3.3982E-06 0 0
A/T 34145 Ig-160 9 rs542891030 0.11 -0.766 0.852 N 0.415 0.139 0.452546404249 gnomAD-2.1.1 2.01E-05 None None None None I None 0 0 None 0 2.78242E-04 None 0 None 0 0 0
A/T 34145 Ig-160 9 rs542891030 0.11 -0.766 0.852 N 0.415 0.139 0.452546404249 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92678E-04 None 0 0 0 0 0
A/T 34145 Ig-160 9 rs542891030 0.11 -0.766 0.852 N 0.415 0.139 0.452546404249 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
A/T 34145 Ig-160 9 rs542891030 0.11 -0.766 0.852 N 0.415 0.139 0.452546404249 gnomAD-4.0.0 3.84199E-06 None None None None I None 0 0 None 0 7.27343E-05 None 0 0 0 0 0
A/V 34145 Ig-160 9 None 0.1918 None 0.959 N 0.436 0.176 0.528308644755 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/D 34266 Ig-161 9 rs1167687090 0.2422 0.581 0.998 N 0.473 0.324 0.112648838833 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
N/D 34266 Ig-161 9 rs1167687090 0.2422 0.581 0.998 N 0.473 0.324 0.112648838833 gnomAD-4.0.0 1.36831E-06 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 8.99408E-07 0 0
N/S 34266 Ig-161 9 None 0.1278 None 0.998 N 0.437 0.352 0.141422826196 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/Y 34266 Ig-161 9 None 0.6832 None 0.999 N 0.671 0.39 0.301789629655 gnomAD-4.0.0 2.05246E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69823E-06 0 0
N/H 34371 Ig-162 9 None 0.6563 None 0.999 N 0.628 0.661 0.401185642668 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 34371 Ig-162 9 None 0.202 None 0.977 N 0.429 0.451 0.243972157842 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/L 34950 Ig-163 9 rs762789368 0.9227 0.006 1.0 N 0.71 0.449 0.534140917371 gnomAD-2.1.1 1.07E-05 None None None None N None 4.13E-05 5.65E-05 None 0 0 None 0 None 0 0 0
S/L 34950 Ig-163 9 rs762789368 0.9227 0.006 1.0 N 0.71 0.449 0.534140917371 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 1.30856E-04 0 0 0 None 0 0 0 0 0
S/L 34950 Ig-163 9 rs762789368 0.9227 0.006 1.0 N 0.71 0.449 0.534140917371 gnomAD-4.0.0 6.4043E-06 None None None None N None 1.69119E-05 6.77736E-05 None 0 0 None 0 0 0 0 0
S/C 35137 Ig-164 9 rs1427963030 0.4801 -0.331 1.0 N 0.742 0.462 0.36036328697 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65399E-04
S/C 35137 Ig-164 9 rs1427963030 0.4801 -0.331 1.0 N 0.742 0.462 0.36036328697 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
S/C 35137 Ig-164 9 rs1427963030 0.4801 -0.331 1.0 N 0.742 0.462 0.36036328697 gnomAD-4.0.0 3.84244E-06 None None None None N None 0 0 None 0 0 None 4.70662E-05 0 0 0 0
S/P 35137 Ig-164 9 rs2154133339 0.3935 None 1.0 N 0.811 0.495 0.242825505644 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.77555E-04
S/P 35137 Ig-164 9 rs2154133339 0.3935 None 1.0 N 0.811 0.495 0.242825505644 gnomAD-4.0.0 2.56149E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39264E-06 0 2.84155E-05
A/G 35294 Ig-165 9 rs569210689 0.1637 None 0.446 N 0.559 0.088 0.152612264143 gnomAD-4.0.0 3.42075E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69822E-06 0 3.31268E-05
A/T 35294 Ig-165 9 rs879080442 0.1509 -0.866 0.284 N 0.556 0.103 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
A/T 35294 Ig-165 9 rs879080442 0.1509 -0.866 0.284 N 0.556 0.103 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/T 35294 Ig-165 9 rs879080442 0.1509 -0.866 0.284 N 0.556 0.103 None gnomAD-4.0.0 1.85899E-06 None None None None N None 4.00555E-05 0 None 0 0 None 0 0 0 0 0
A/V 35294 Ig-165 9 rs569210689 0.1743 0.214 0.001 N 0.29 0.073 0.139678290688 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 1.63399E-04 None 0 0 0
A/V 35294 Ig-165 9 rs569210689 0.1743 0.214 0.001 N 0.29 0.073 0.139678290688 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.079E-04 0
A/V 35294 Ig-165 9 rs569210689 0.1743 0.214 0.001 N 0.29 0.073 0.139678290688 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
A/V 35294 Ig-165 9 rs569210689 0.1743 0.214 0.001 N 0.29 0.073 0.139678290688 gnomAD-4.0.0 8.05499E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.42757E-04 0
D/V 35428 Ig-166 9 rs759065895 0.6497 0.258 0.999 N 0.679 0.377 0.507807437176 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/V 35428 Ig-166 9 rs759065895 0.6497 0.258 0.999 N 0.679 0.377 0.507807437176 gnomAD-4.0.0 4.77287E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.29812E-05 0
S/C 35710 Ig-168 9 None 0.3798 None 1.0 N 0.84 0.438 0.370789594751 gnomAD-4.0.0 6.84788E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16236E-05 0
S/F 35710 Ig-168 9 rs1194921895 0.637 -0.67 1.0 N 0.908 0.467 0.514811571519 gnomAD-2.1.1 4.06E-06 None None None None N None 6.57E-05 0 None 0 0 None 0 None 0 0 0
S/F 35710 Ig-168 9 rs1194921895 0.637 -0.67 1.0 N 0.908 0.467 0.514811571519 gnomAD-4.0.0 1.36958E-06 None None None None N None 5.97729E-05 0 None 0 0 None 0 0 0 0 0
S/P 35710 Ig-168 9 None 0.2706 None 1.0 N 0.877 0.435 0.141422826196 gnomAD-4.0.0 6.8473E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99879E-07 0 0
D/G 35905 Ig-169 9 rs1558955826 0.5879 None 0.998 N 0.764 0.444 0.1749357433 gnomAD-2.1.1 4.07E-06 None None None -0.422(OBSL1) -0.723(OBSCN) N None 0 0 None 0 0 None 0 None 0 9E-06 0
D/G 35905 Ig-169 9 rs1558955826 0.5879 None 0.998 N 0.764 0.444 0.1749357433 gnomAD-4.0.0 1.60915E-06 None None None -0.422(OBSL1) -0.723(OBSCN) N None 0 0 None 0 0 None 0 0 2.89974E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.