Structural position:

  • Domain Type: Ig
  • Aligned Position: 13
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A'

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
V/A 15 Ig-1 10 rs1471462382 0.1498 -0.906 0.995 N 0.476 0.524 0.793074248023 gnomAD-2.1.1 1.19E-05 None None None -0.798(TCAP) N None 0 5.78E-05 None 0 0 None 3.27E-05 None 0 0 0
V/A 15 Ig-1 10 rs1471462382 0.1498 -0.906 0.995 N 0.476 0.524 0.793074248023 gnomAD-4.0.0 4.10473E-06 None None None -0.798(TCAP) N None 0 4.47227E-05 None 0 0 None 0 0 2.69801E-06 1.15969E-05 0
V/I 15 Ig-1 10 rs201857541 0.092 0.073 0.681 N 0.257 0.269 None gnomAD-2.1.1 1.48668E-04 None None None -1.001(TCAP) N None 0 8.47E-05 None 5.79486E-04 5.02E-05 None 4.25059E-04 None 0 1.47342E-04 0
V/I 15 Ig-1 10 rs201857541 0.092 0.073 0.681 N 0.257 0.269 None gnomAD-3.1.2 1.11741E-04 None None None -1.001(TCAP) N None 0 1.30907E-04 0 0 0 None 0 0 1.76393E-04 6.21891E-04 0
V/I 15 Ig-1 10 rs201857541 0.092 0.073 0.681 N 0.257 0.269 None 1000 genomes 1.99681E-04 None None None -1.001(TCAP) N None 0 0 None None 0 0 None None None 1E-03 None
V/I 15 Ig-1 10 rs201857541 0.092 0.073 0.681 N 0.257 0.269 None gnomAD-4.0.0 9.23189E-05 None None None -1.001(TCAP) N None 2.66553E-05 8.33111E-05 None 4.72941E-04 2.22886E-05 None 4.68691E-05 0 7.03422E-05 3.73438E-04 1.12014E-04
M/I 113 Ig-2 10 None 0.7572 None 0.008 N 0.119 0.241 0.44143026662 gnomAD-4.0.0 1.59693E-06 None None None -0.817(TCAP) N None 0 0 None 0 0 None 0 0 0 1.44155E-05 0
M/T 113 Ig-2 10 rs2094010012 0.6264 None 0.013 N 0.167 0.343 0.676897640743 gnomAD-4.0.0 3.60097E-06 None None None -0.344(TCAP) N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
M/V 113 Ig-2 10 rs1060500430 0.2009 -0.479 0.226 N 0.289 0.253 0.420570264827 gnomAD-2.1.1 4.02E-06 None None None -0.839(TCAP) N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
M/V 113 Ig-2 10 rs1060500430 0.2009 -0.479 0.226 N 0.289 0.253 0.420570264827 gnomAD-4.0.0 3.19452E-06 None None None -0.839(TCAP) N None 0 2.29474E-05 None 0 0 None 0 0 2.8686E-06 0 0
V/L 952 Ig-3 10 rs373848402 0.3872 -0.359 0.001 N 0.098 0.179 0.420570264827 gnomAD-2.1.1 1.2E-05 None None None None N None 1.92184E-04 0 None 0 0 None 0 None 0 0 0
V/L 952 Ig-3 10 rs373848402 0.3872 -0.359 0.001 N 0.098 0.179 0.420570264827 gnomAD-3.1.2 3.94E-05 None None None None N None 1.44851E-04 0 0 0 0 None 0 0 0 0 0
V/L 952 Ig-3 10 rs373848402 0.3872 -0.359 0.001 N 0.098 0.179 0.420570264827 gnomAD-4.0.0 6.84097E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99321E-07 0 0
V/M 952 Ig-3 10 None 0.1787 None 0.015 N 0.283 0.135 0.432716982437 gnomAD-4.0.0 6.84097E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
Q/E 1091 Ig-4 10 rs794729528 0.1616 None 0.78 N 0.471 0.315 0.260249123532 gnomAD-4.0.0 2.05222E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6979E-06 0 0
Q/R 1091 Ig-4 10 rs779873815 0.2605 -0.133 0.896 N 0.486 0.392 0.21279746466 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.81E-06 0
Q/R 1091 Ig-4 10 rs779873815 0.2605 -0.133 0.896 N 0.486 0.392 0.21279746466 gnomAD-4.0.0 1.59052E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85652E-06 0 0
Y/C 1300 Ig-5 10 rs188090472 0.3693 -1.228 1.0 N 0.764 0.651 None gnomAD-2.1.1 2E-05 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 3.55E-05 0
Y/C 1300 Ig-5 10 rs188090472 0.3693 -1.228 1.0 N 0.764 0.651 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 0 0
Y/C 1300 Ig-5 10 rs188090472 0.3693 -1.228 1.0 N 0.764 0.651 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
Y/C 1300 Ig-5 10 rs188090472 0.3693 -1.228 1.0 N 0.764 0.651 None gnomAD-4.0.0 1.79729E-05 None None None None I None 0 0 None 0 0 None 0 0 2.45857E-05 0 0
Y/H 1300 Ig-5 10 rs1574706508 0.4333 None 1.0 N 0.674 0.528 0.585382094262 gnomAD-4.0.0 1.36849E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79896E-06 0 0
Y/N 1300 Ig-5 10 None 0.5617 None 1.0 N 0.805 0.706 0.819341713775 gnomAD-4.0.0 6.84244E-07 None None None None I None 0 0 None 3.82702E-05 0 None 0 0 0 0 0
F/L 1466 Ig-6 10 rs151310601 0.7825 -1.027 0.005 N 0.137 0.221 0.301122078929 gnomAD-2.1.1 6.8711E-04 None None None None I None 4.80731E-04 2.8247E-04 None 4.82812E-04 0 None 6.53E-05 None 3.98E-05 1.24245E-03 5.55401E-04
F/L 1466 Ig-6 10 rs151310601 0.7825 -1.027 0.005 N 0.137 0.221 0.301122078929 gnomAD-3.1.2 8.67325E-04 None None None None I None 5.06634E-04 3.27097E-04 0 5.77034E-04 0 None 0 0 1.49921E-03 2.07211E-04 4.78011E-04
F/L 1466 Ig-6 10 rs151310601 0.7825 -1.027 0.005 N 0.137 0.221 0.301122078929 1000 genomes 3.99361E-04 None None None None I None 0 0 None None 0 1E-03 None None None 1E-03 None
F/L 1466 Ig-6 10 rs151310601 0.7825 -1.027 0.005 N 0.137 0.221 0.301122078929 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 1565 Ig-7 10 rs1441856975 0.2186 -1.113 0.052 N 0.327 0.315 0.540925512045 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 1565 Ig-7 10 rs1441856975 0.2186 -1.113 0.052 N 0.327 0.315 0.540925512045 gnomAD-4.0.0 1.36825E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0
V/D 1565 Ig-7 10 rs1441856975 0.5479 None 0.484 D 0.461 0.556 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/D 1565 Ig-7 10 rs1441856975 0.5479 None 0.484 D 0.461 0.556 None gnomAD-4.0.0 4.33723E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93229E-06 0 0
V/I 1565 Ig-7 10 rs762529971 0.0671 -0.336 None N 0.082 0.146 0.202949470691 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.77E-05 0
V/I 1565 Ig-7 10 rs762529971 0.0671 -0.336 None N 0.082 0.146 0.202949470691 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 1565 Ig-7 10 rs762529971 0.0671 -0.336 None N 0.082 0.146 0.202949470691 gnomAD-4.0.0 2.60237E-05 None None None None N None 0 0 None 0 0 None 0 0 3.47464E-05 1.09784E-05 0
Q/R 2087 Ig-10 10 rs1477007971 0.3465 0.012 0.961 N 0.469 0.373 0.237489013734 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
Q/R 2087 Ig-10 10 rs1477007971 0.3465 0.012 0.961 N 0.469 0.373 0.237489013734 gnomAD-4.0.0 1.5906E-06 None None None None N None 0 0 None 0 2.77393E-05 None 0 0 0 0 0
V/I 2183 Ig-11 10 rs940814498 0.0718 -0.354 0.245 N 0.525 0.12 0.618912533594 gnomAD-2.1.1 1.06E-05 None None None None N None 4.01E-05 2.82E-05 None 0 0 None 3.27E-05 None 0 0 0
V/I 2183 Ig-11 10 rs940814498 0.0718 -0.354 0.245 N 0.525 0.12 0.618912533594 gnomAD-3.1.2 3.94E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 1.47E-05 2.06868E-04 0
V/I 2183 Ig-11 10 rs940814498 0.0718 -0.354 0.245 N 0.525 0.12 0.618912533594 gnomAD-4.0.0 8.67516E-06 None None None None N None 1.06863E-04 5.001E-05 None 0 0 None 0 0 1.69496E-06 1.09782E-05 0
I/M 2276 Ig-12 10 rs780309167 0.0923 -0.663 0.901 N 0.455 0.188 0.453588565359 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
I/M 2276 Ig-12 10 rs780309167 0.0923 -0.663 0.901 N 0.455 0.188 0.453588565359 gnomAD-4.0.0 4.77617E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57138E-06 0 0
I/T 2276 Ig-12 10 None 0.0968 None 0.722 N 0.525 0.308 0.633325178372 gnomAD-4.0.0 2.40078E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62515E-06 0 0
I/V 2276 Ig-12 10 rs794729578 0.0687 -1.029 0.003 N 0.131 0.089 0.378322506985 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.46E-05 None 0 None 0 0 0
I/V 2276 Ig-12 10 rs794729578 0.0687 -1.029 0.003 N 0.131 0.089 0.378322506985 gnomAD-4.0.0 1.36882E-06 None None None None N None 0 0 None 0 2.52156E-05 None 0 0 8.99399E-07 0 0
Q/H 2365 Ig-13 10 rs755961734 0.3787 -0.563 0.991 D 0.347 0.31 0.339074221408 gnomAD-2.1.1 3.99E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
V/D 2454 Ig-14 10 rs2091855424 0.3971 None 0.81 D 0.559 0.752 0.86537904985 gnomAD-4.0.0 1.59073E-06 None None None None N None 5.65291E-05 0 None 0 0 None 0 0 0 0 0
L/I 2542 Ig-15 10 rs762722498 0.0531 -0.36 None N 0.101 0.098 0.385906861911 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/I 2542 Ig-15 10 rs762722498 0.0531 -0.36 None N 0.101 0.098 0.385906861911 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
L/I 2542 Ig-15 10 rs762722498 0.0531 -0.36 None N 0.101 0.098 0.385906861911 gnomAD-4.0.0 1.85896E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.29402E-05 0
L/P 2542 Ig-15 10 None 0.8479 None 0.106 N 0.5 0.381 0.655220577254 gnomAD-4.0.0 1.59082E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85669E-06 0 0
Q/H 2629 Ig-16 9 rs1360901635 0.2782 None None N 0.155 0.113 0.223847106136 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30976E-04 0 0 0 None 0 0 0 0 0
Q/H 2629 Ig-16 9 rs1360901635 0.2782 None None N 0.155 0.113 0.223847106136 gnomAD-4.0.0 1.31432E-05 None None None None N None 0 1.30976E-04 None 0 0 None 0 0 0 0 0
L/P 2716 Ig-17 10 rs752870590 0.9818 -0.756 0.984 D 0.59 0.608 0.861400942078 gnomAD-2.1.1 3.99E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
L/P 2716 Ig-17 10 rs752870590 0.9818 -0.756 0.984 D 0.59 0.608 0.861400942078 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
L/P 2716 Ig-17 10 rs752870590 0.9818 -0.756 0.984 D 0.59 0.608 0.861400942078 gnomAD-4.0.0 5.12554E-06 None None None None N None 0 6.77897E-05 None 0 0 None 0 0 0 0 0
I/M 2891 Ig-19 10 rs766867322 0.081 None 0.99 N 0.523 0.417 0.406120066682 gnomAD-4.0.0 1.36819E-06 None None None None N None 0 0 None 0 2.52092E-05 None 0 0 8.99302E-07 0 0
I/T 2891 Ig-19 10 rs774651047 0.0867 -1.38 0.92 N 0.462 0.486 0.743453827052 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
I/V 2891 Ig-19 10 None 0.0672 None 0.061 N 0.149 0.094 0.468336420597 gnomAD-4.0.0 1.5906E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
I/L 3067 Ig-21 10 None 0.2263 None 0.993 N 0.33 0.294 0.588202069064 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
I/M 3067 Ig-21 10 None 0.1714 None 1.0 D 0.674 0.365 0.513503867364 gnomAD-4.0.0 1.59066E-06 None None None None N None 0 0 None 0 2.77716E-05 None 0 0 0 0 0
I/T 3067 Ig-21 10 rs1435097269 0.6283 -2.102 1.0 N 0.689 0.572 0.739398645562 gnomAD-2.1.1 1.2E-05 None None None None N None 0 8.68E-05 None 0 0 None 0 None 0 0 0
I/T 3067 Ig-21 10 rs1435097269 0.6283 -2.102 1.0 N 0.689 0.572 0.739398645562 gnomAD-4.0.0 6.36266E-06 None None None None N None 0 6.86059E-05 None 0 0 None 0 0 0 0 3.0217E-05
I/V 3067 Ig-21 10 rs2154341582 0.1378 None 0.993 N 0.33 0.175 0.649418150632 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9216E-04 None 0 0 0 0 0
I/V 3067 Ig-21 10 rs2154341582 0.1378 None 0.993 N 0.33 0.175 0.649418150632 gnomAD-4.0.0 6.56418E-06 None None None None N None 0 0 None 0 1.92604E-04 None 0 0 0 0 0
V/F 3156 Ig-22 10 rs1403999393 0.4088 -1.16 0.982 N 0.577 0.414 0.723455425128 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
V/F 3156 Ig-22 10 rs1403999393 0.4088 -1.16 0.982 N 0.577 0.414 0.723455425128 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/F 3156 Ig-22 10 rs1403999393 0.4088 -1.16 0.982 N 0.577 0.414 0.723455425128 gnomAD-4.0.0 6.57229E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47007E-05 0 0
V/I 3156 Ig-22 10 None 0.0896 None 0.02 N 0.196 0.229 0.359963025489 gnomAD-4.0.0 1.36826E-06 None None None None N None 0 0 None 0 2.51915E-05 None 0 0 8.9931E-07 0 0
V/A 3248 Ig-23 10 rs2090056123 0.0874 None None N 0.076 0.119 0.324436698001 gnomAD-4.0.0 1.59135E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
V/I 3248 Ig-23 10 rs754873655 0.0614 -0.231 None N 0.091 0.178 0.181679512989 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 3248 Ig-23 10 rs754873655 0.0614 -0.231 None N 0.091 0.178 0.181679512989 gnomAD-4.0.0 1.3685E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31895E-05 0
T/I 3354 Ig-24 10 rs1487871864 0.1239 None None N 0.209 0.045 0.32980341726 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 3354 Ig-24 10 rs1487871864 0.1239 None None N 0.209 0.045 0.32980341726 gnomAD-4.0.0 6.56996E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
V/A 3669 Ig-26 10 None 0.1555 None None None None 0.257 None gnomAD-4.0.0 1.59131E-06 None None None None I None 0 0 None 0 2.77546E-05 None 0 0 0 0 0
V/F 3669 Ig-26 10 rs748260785 0.114 -1.22 None None None 0.146 None gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/F 3669 Ig-26 10 rs748260785 0.114 -1.22 None None None 0.146 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/F 3669 Ig-26 10 rs748260785 0.114 -1.22 None None None 0.146 None gnomAD-4.0.0 1.2394E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69519E-06 0 0
V/I 3669 Ig-26 10 rs748260785 0.0573 -0.44 None None None 0.152 None gnomAD-2.1.1 1.21E-05 None None None None I None 1.29166E-04 0 None 0 0 None 0 None 0 8.88E-06 0
V/I 3669 Ig-26 10 rs748260785 0.0573 -0.44 None None None 0.152 None gnomAD-3.1.2 3.29E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 3.16456E-03 1.47E-05 0 0
V/I 3669 Ig-26 10 rs748260785 0.0573 -0.44 None None None 0.152 None gnomAD-4.0.0 3.34613E-05 None None None None I None 5.33006E-05 0 None 1.68873E-04 0 None 0 1.65071E-04 3.3904E-05 2.19568E-05 3.20102E-05
A/G 3829 Ig-27 10 rs778583163 0.1759 -1.056 0.193 N 0.492 0.115 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11782E-04 None 0 None 0 0 0
A/G 3829 Ig-27 10 rs778583163 0.1759 -1.056 0.193 N 0.492 0.115 None gnomAD-4.0.0 3.18325E-06 None None None None N None 0 0 None 0 2.77701E-05 None 0 0 2.85866E-06 0 0
A/S 3829 Ig-27 10 rs745332301 0.1066 -1.08 0.003 N 0.165 0.087 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
A/S 3829 Ig-27 10 rs745332301 0.1066 -1.08 0.003 N 0.165 0.087 None gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 2.77716E-05 None 0 0 0 0 0
A/V 3829 Ig-27 10 rs778583163 0.1048 -0.089 0.001 N 0.169 0.071 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
A/V 3829 Ig-27 10 rs778583163 0.1048 -0.089 0.001 N 0.169 0.071 None gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 2.77701E-05 None 0 0 0 0 0
I/M 3947 Ig-28 10 None 0.1206 None 0.171 N 0.376 0.078 None gnomAD-4.0.0 1.59106E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
T/A 4615 Ig-29 10 rs751677635 0.0805 -0.959 None N 0.099 0.112 0.0297737177859 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/A 4615 Ig-29 10 rs751677635 0.0805 -0.959 None N 0.099 0.112 0.0297737177859 gnomAD-4.0.0 1.36838E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7989E-06 0 0
L/P 4709 Ig-30 10 rs756566095 0.9263 -1.035 0.971 D 0.72 0.548 0.731923157262 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
L/P 4709 Ig-30 10 rs756566095 0.9263 -1.035 0.971 D 0.72 0.548 0.731923157262 gnomAD-4.0.0 1.59303E-06 None None None None I None 0 0 None 0 2.78149E-05 None 0 0 0 0 0
Y/C 4991 Ig-33 11 None 0.1737 None 0.999 N 0.292 0.433 0.436886369515 gnomAD-4.0.0 1.37791E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.3483E-05 0
Y/F 4991 Ig-33 11 rs1422915877 0.0956 -0.355 0.035 N 0.135 0.128 0.219573609325 gnomAD-2.1.1 4.36E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.84E-06 0
Y/F 4991 Ig-33 11 rs1422915877 0.0956 -0.355 0.035 N 0.135 0.128 0.219573609325 gnomAD-4.0.0 1.37791E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80825E-06 0 0
Y/N 4991 Ig-33 11 None 0.2722 None 0.996 N 0.324 0.3 0.546780063783 gnomAD-4.0.0 2.75639E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61706E-06 0 0
Y/S 4991 Ig-33 11 None 0.2158 None 0.986 N 0.33 0.435 0.55350970329 gnomAD-4.0.0 6.88954E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04126E-07 0 0
A/E 5084 Ig-34 10 rs748125393 0.2257 -1.035 0.81 N 0.405 0.324 0.569491761652 gnomAD-2.1.1 4.39E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.53E-06 0
A/E 5084 Ig-34 10 rs748125393 0.2257 -1.035 0.81 N 0.405 0.324 0.569491761652 gnomAD-4.0.0 4.18523E-06 None None None None N None 0 0 None 0 0 None 0 0 3.64473E-06 0 3.38043E-05
A/V 5084 Ig-34 10 rs748125393 0.1148 None 0.007 N 0.106 0.172 0.28058544554 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/V 5084 Ig-34 10 rs748125393 0.1148 None 0.007 N 0.106 0.172 0.28058544554 gnomAD-4.0.0 1.26122E-06 None None None None N None 1.35259E-05 0 None 0 0 None 0 0 8.58002E-07 0 0
L/W 5177 Ig-35 10 rs1205797095 0.092 None 0.612 D 0.49 0.354 0.810717827077 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92678E-04 None 0 0 0 0 0
L/W 5177 Ig-35 10 rs1205797095 0.092 None 0.612 D 0.49 0.354 0.810717827077 gnomAD-4.0.0 6.5716E-06 None None None None I None 0 0 None 0 1.92678E-04 None 0 0 0 0 0
V/G 5366 Ig-37 10 rs754980942 0.1803 -1.779 0.782 N 0.684 0.632 None gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.04E-06 0
V/G 5366 Ig-37 10 rs754980942 0.1803 -1.779 0.782 N 0.684 0.632 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/G 5366 Ig-37 10 rs754980942 0.1803 -1.779 0.782 N 0.684 0.632 None gnomAD-4.0.0 2.49006E-06 None None None None N None 0 0 None 0 0 None 0 0 3.40271E-06 0 0
V/M 5366 Ig-37 10 rs372176136 0.0938 -0.65 0.543 D 0.445 0.121 0.413891365518 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.05E-06 0
V/M 5366 Ig-37 10 rs372176136 0.0938 -0.65 0.543 D 0.445 0.121 0.413891365518 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/M 5366 Ig-37 10 rs372176136 0.0938 -0.65 0.543 D 0.445 0.121 0.413891365518 gnomAD-4.0.0 3.2364E-05 None None None None N None 0 0 None 0 0 None 0 0 4.33786E-05 0 1.60958E-05
S/L 5552 Ig-39 10 None 0.092 None 0.669 N 0.339 0.272 0.641217788028 gnomAD-4.0.0 1.59916E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87325E-06 0 0
I/V 5646 Ig-40 10 rs753025325 0.0555 -0.982 None N 0.075 0.128 0.119812018005 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
I/V 5646 Ig-40 10 rs753025325 0.0555 -0.982 None N 0.075 0.128 0.119812018005 gnomAD-4.0.0 2.05815E-06 None None None None N None 0 0 None 0 2.5264E-05 None 0 0 1.80382E-06 0 0
T/I 5739 Ig-41 10 rs751087281 0.09 None 0.001 N 0.193 0.159 0.388174495139 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 5739 Ig-41 10 rs751087281 0.09 None 0.001 N 0.193 0.159 0.388174495139 gnomAD-4.0.0 6.57566E-06 None None None None N None 2.41476E-05 0 None 0 0 None 0 0 0 0 0
T/N 5739 Ig-41 10 None 0.1163 -0.042 0.351 N 0.375 0.26 None gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
T/S 5739 Ig-41 10 rs751087281 0.0995 -0.407 0.021 D 0.183 0.145 0.21737058555 gnomAD-4.0.0 3.1997E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.87604E-05 0
I/T 5832 Ig-42 10 rs1222549953 0.1247 -1.001 0.103 N 0.255 0.223 0.591820399129 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.11383E-04 None 0 None 0 0 1.65837E-04
I/T 5832 Ig-42 10 rs1222549953 0.1247 -1.001 0.103 N 0.255 0.223 0.591820399129 gnomAD-4.0.0 2.73726E-06 None None None None N None 0 0 None 0 5.03931E-05 None 0 0 1.7992E-06 0 0
M/I 5928 Ig-43 10 rs752412937 0.4018 -0.202 0.679 N 0.215 0.21 0.429552544315 gnomAD-2.1.1 8.17E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 9.08E-06 0
M/I 5928 Ig-43 10 rs752412937 0.4018 -0.202 0.679 N 0.215 0.21 0.429552544315 gnomAD-4.0.0 1.60558E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89024E-06 0 0
M/K 5928 Ig-43 10 rs1337129774 0.2294 0.37 0.837 N 0.253 0.368 0.629843413301 gnomAD-2.1.1 4.08E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
M/K 5928 Ig-43 10 rs1337129774 0.2294 0.37 0.837 N 0.253 0.368 0.629843413301 gnomAD-4.0.0 1.60533E-06 None None None None N None 0 2.30203E-05 None 0 0 None 0 0 0 0 0
Q/E 6021 Ig-44 10 rs1302820509 0.096 0.207 0.983 N 0.333 0.34 0.407901774203 gnomAD-2.1.1 4.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.2E-06 0
Q/E 6021 Ig-44 10 rs1302820509 0.096 0.207 0.983 N 0.333 0.34 0.407901774203 gnomAD-4.0.0 1.6055E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88374E-06 0 0
Q/H 6021 Ig-44 10 rs752853744 0.3101 -0.552 0.998 N 0.367 0.409 0.343334270461 gnomAD-2.1.1 4.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.19E-06 0
Q/H 6021 Ig-44 10 rs752853744 0.3101 -0.552 0.998 N 0.367 0.409 0.343334270461 gnomAD-4.0.0 2.06005E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70552E-06 0 0
V/A 6114 Ig-45 10 None 0.1253 None 0.012 N 0.129 0.174 0.499535901811 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/D 6114 Ig-45 10 None 0.1758 None 0.966 D 0.415 0.461 0.811599919723 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
V/I 6114 Ig-45 10 rs762371825 0.0757 -0.115 0.051 N 0.189 0.137 0.403609169532 gnomAD-2.1.1 8.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/I 6114 Ig-45 10 rs762371825 0.0757 -0.115 0.051 N 0.189 0.137 0.403609169532 gnomAD-4.0.0 9.58383E-06 None None None None I None 0 0 None 0 0 None 0 0 1.16956E-05 0 1.65804E-05
V/L 6208 Ig-46 10 rs759379332 0.142 -0.359 0.001 N 0.118 0.273 0.284150004643 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/L 6208 Ig-46 10 rs759379332 0.142 -0.359 0.001 N 0.118 0.273 0.284150004643 gnomAD-4.0.0 1.59263E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43357E-05 0
V/M 6208 Ig-46 10 rs759379332 0.0975 -0.393 0.655 D 0.416 0.385 0.430579932962 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.82E-05 None 0 0 0
V/M 6208 Ig-46 10 rs759379332 0.0975 -0.393 0.655 D 0.416 0.385 0.430579932962 gnomAD-4.0.0 1.2741E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.14685E-04 0
T/S 6301 Ig-47 10 rs755238352 0.1005 -0.745 0.001 N 0.135 0.063 0.115124310173 gnomAD-2.1.1 4.32E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.49E-06 0
T/S 6301 Ig-47 10 rs755238352 0.1005 -0.745 0.001 N 0.135 0.063 0.115124310173 gnomAD-4.0.0 1.63359E-06 None None None None N None 0 0 None 0 0 None 0 0 2.92124E-06 0 0
V/D 6394 Ig-48 10 rs969002490 0.4131 None 0.912 N 0.465 0.683 0.886122297003 gnomAD-4.0.0 1.37542E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80886E-06 0 0
V/L 6394 Ig-48 10 rs370515485 0.1633 -0.295 0.001 N 0.108 0.055 None gnomAD-2.1.1 8.61E-05 None None None None N None 0 0 None 0 0 None 0 None 2.81124E-04 1.17616E-04 2.82725E-04
V/L 6394 Ig-48 10 rs370515485 0.1633 -0.295 0.001 N 0.108 0.055 None gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 2.82752E-04 0 4.41E-05 0 0
V/L 6394 Ig-48 10 rs370515485 0.1633 -0.295 0.001 N 0.108 0.055 None gnomAD-4.0.0 3.55271E-05 None None None None N None 0 0 None 3.3896E-05 0 None 2.97433E-04 0 2.98586E-05 0 3.22487E-05
M/I 6490 Ig-49 10 rs746981434 0.2147 -0.872 0.023 N 0.165 0.236 0.359963025489 gnomAD-2.1.1 4.21E-06 None None None None N None 0 0 None 1.05664E-04 0 None 0 None 0 0 0
M/I 6490 Ig-49 10 rs746981434 0.2147 -0.872 0.023 N 0.165 0.236 0.359963025489 gnomAD-4.0.0 4.83993E-06 None None None None N None 0 0 None 9.71628E-05 0 None 0 0 2.88414E-06 0 0
M/T 6490 Ig-49 10 rs769527897 0.1673 -0.773 0.023 N 0.225 0.353 0.689162798981 gnomAD-2.1.1 8.48E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.87E-05 0
M/T 6490 Ig-49 10 rs769527897 0.1673 -0.773 0.023 N 0.225 0.353 0.689162798981 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 6490 Ig-49 10 rs769527897 0.1673 -0.773 0.023 N 0.225 0.353 0.689162798981 gnomAD-4.0.0 4.364E-06 None None None None N None 0 0 None 0 0 None 0 0 5.95161E-06 0 0
Q/R 6583 Ig-50 10 rs1370326075 0.139 None 0.135 N 0.205 0.219 0.218112801441 gnomAD-4.0.0 1.61836E-06 None None None None N None 0 0 None 0 2.78458E-05 None 0 0 0 0 0
S/F 6676 Ig-51 10 rs746565627 0.2647 -0.629 None N 0.224 0.325 0.486352402194 gnomAD-2.1.1 1.09E-05 None None None None N None 4.15E-05 0 None 0 0 None 0 None 0 1.58E-05 0
S/F 6676 Ig-51 10 rs746565627 0.2647 -0.629 None N 0.224 0.325 0.486352402194 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 6676 Ig-51 10 rs746565627 0.2647 -0.629 None N 0.224 0.325 0.486352402194 gnomAD-4.0.0 1.43138E-05 None None None None N None 1.34217E-05 0 None 0 0 None 0 0 1.8704E-05 0 0
S/Y 6676 Ig-51 10 rs746565627 0.2615 None 0.022 N 0.511 0.259 0.466907325337 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/Y 6676 Ig-51 10 rs746565627 0.2615 None 0.022 N 0.511 0.259 0.466907325337 gnomAD-4.0.0 2.48935E-06 None None None None N None 0 0 None 0 0 None 0 0 3.40072E-06 0 0
V/A 6770 Ig-52 10 None 0.1381 None 0.007 N 0.107 0.156 0.497613835824 gnomAD-4.0.0 1.74383E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.6619E-05 0
V/I 6770 Ig-52 10 None 0.0747 None 0.003 N 0.162 0.136 0.421427970867 gnomAD-4.0.0 7.12211E-07 None None None None N None 0 0 None 0 0 None 0 0 9.25799E-07 0 0
V/L 6770 Ig-52 10 None 0.1662 None 0.001 N 0.099 0.136 0.340510301474 gnomAD-4.0.0 2.84884E-06 None None None None N None 0 0 None 0 0 None 0 0 3.7032E-06 0 0
M/I 6957 Ig-54 10 None 0.2481 None 0.001 N 0.065 0.201 0.37550373646 gnomAD-4.0.0 1.37525E-06 None None None None N None 0 0 None 0 0 None 0 0 9.03917E-07 0 1.66556E-05
M/L 6957 Ig-54 10 rs375262781 0.1354 -0.148 0.065 N 0.107 0.212 0.478755181577 gnomAD-2.1.1 2.16E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.94E-05 1.41924E-04
M/L 6957 Ig-54 10 rs375262781 0.1354 -0.148 0.065 N 0.107 0.212 0.478755181577 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/L 6957 Ig-54 10 rs375262781 0.1354 -0.148 0.065 N 0.107 0.212 0.478755181577 gnomAD-4.0.0 2.98795E-05 None None None None N None 0 0 None 0 0 None 0 0 3.91713E-05 0 3.21937E-05
M/R 6957 Ig-54 10 None 0.1627 None 0.975 N 0.429 0.395 0.696953486674 gnomAD-4.0.0 1.60957E-06 None None None None N None 0 0 None 0 0 None 0 0 2.90274E-06 0 0
M/T 6957 Ig-54 10 rs754721444 0.1517 -0.078 0.425 N 0.309 0.32 None gnomAD-2.1.1 4.06E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
M/T 6957 Ig-54 10 rs754721444 0.1517 -0.078 0.425 N 0.309 0.32 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/T 6957 Ig-54 10 rs754721444 0.1517 -0.078 0.425 N 0.309 0.32 None gnomAD-4.0.0 2.58602E-06 None None None None N None 3.39432E-05 0 None 0 0 None 0 0 0 0 0
T/P 7053 Ig-55 10 rs727504741 0.2273 -0.361 0.859 N 0.539 0.405 0.478222008075 gnomAD-2.1.1 7.19E-05 None None None None N None 0 0 None 3.88651E-04 1.02891E-04 None 3.93211E-04 None 0 0 2.82725E-04
T/P 7053 Ig-55 10 rs727504741 0.2273 -0.361 0.859 N 0.539 0.405 0.478222008075 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 4.78011E-04
T/P 7053 Ig-55 10 rs727504741 0.2273 -0.361 0.859 N 0.539 0.405 0.478222008075 gnomAD-4.0.0 4.03024E-05 None None None None N None 0 0 None 3.71848E-04 2.90062E-04 None 0 0 4.24005E-06 3.62534E-04 4.80769E-05
H/R 7239 Ig-57 10 None 0.0912 None 0.007 N 0.279 0.111 0.165133752707 gnomAD-4.0.0 3.1845E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71922E-06 0 0
L/Q 7332 Ig-58 10 rs369522109 0.0734 -0.529 0.966 N 0.351 0.509 None gnomAD-2.1.1 2.43E-05 None None None None I None 3.89257E-04 0 None 0 0 None 0 None 0 0 0
L/Q 7332 Ig-58 10 rs369522109 0.0734 -0.529 0.966 N 0.351 0.509 None gnomAD-3.1.2 8.54E-05 None None None None I None 2.89436E-04 6.55E-05 0 0 0 None 0 0 0 0 0
L/Q 7332 Ig-58 10 rs369522109 0.0734 -0.529 0.966 N 0.351 0.509 None gnomAD-4.0.0 1.36422E-05 None None None None I None 2.80404E-04 1.67017E-05 None 0 0 None 0 0 0 0 0
I/S 7428 Ig-59 10 None 0.189 None 0.062 N 0.399 0.328 0.807768874225 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/V 7428 Ig-59 10 rs1211184600 0.0665 -1.078 None N 0.115 0.035 0.358744678677 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/V 7428 Ig-59 10 rs1211184600 0.0665 -1.078 None N 0.115 0.035 0.358744678677 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 7428 Ig-59 10 rs1211184600 0.0665 -1.078 None N 0.115 0.035 0.358744678677 gnomAD-4.0.0 1.85966E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54345E-06 0 0
I/T 7524 Ig-60 10 None 0.08 None 0.642 N 0.364 0.315 0.669942640896 gnomAD-4.0.0 1.61251E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.47063E-05 0
I/V 7524 Ig-60 10 None 0.0626 None 0.01 N 0.117 0.187 0.42805410278 gnomAD-4.0.0 3.22771E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89729E-06 1.47336E-05 0
V/A 7711 Ig-62 10 None 0.1108 None 0.003 N 0.225 0.242 0.417843521124 gnomAD-4.0.0 1.60995E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88123E-06 0 0
V/L 7711 Ig-62 10 rs771533917 0.1386 -0.173 None N 0.103 0.155 0.107399877778 gnomAD-2.1.1 1.67E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.66E-05 0
V/L 7711 Ig-62 10 rs771533917 0.1386 -0.173 None N 0.103 0.155 0.107399877778 gnomAD-4.0.0 3.4435E-06 None None None None N None 3.04173E-05 0 None 0 0 None 0 0 3.61013E-06 0 0
T/A 7804 Ig-63 10 rs1319873133 0.0788 -0.278 None N 0.082 0.075 0.170165803431 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
T/A 7804 Ig-63 10 rs1319873133 0.0788 -0.278 None N 0.082 0.075 0.170165803431 gnomAD-4.0.0 1.59579E-06 None None None None I None 0 0 None 0 2.77485E-05 None 0 0 0 0 0
M/I 7898 Ig-64 10 rs751897366 0.2602 -0.435 0.001 N 0.057 0.139 0.339793275041 gnomAD-2.1.1 6.07E-05 None None None None N None 0 0 None 0 0 None 4.90966E-04 None 0 0 0
M/I 7898 Ig-64 10 rs751897366 0.2602 -0.435 0.001 N 0.057 0.139 0.339793275041 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 0 8.28157E-04 0
M/I 7898 Ig-64 10 rs751897366 0.2602 -0.435 0.001 N 0.057 0.139 0.339793275041 gnomAD-4.0.0 6.84579E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99938E-07 0 0
V/E 7994 Ig-65 10 None 0.1394 None 0.033 N 0.383 0.341 0.290222751274 gnomAD-4.0.0 1.59218E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86102E-06 0 0
V/L 7994 Ig-65 10 rs779653609 0.1088 -0.213 None N 0.047 0.169 0.0920862733494 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/L 7994 Ig-65 10 rs779653609 0.1088 -0.213 None N 0.047 0.169 0.0920862733494 gnomAD-4.0.0 6.84442E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15955E-05 0
V/M 7994 Ig-65 10 rs779653609 0.0677 -0.301 0.003 N 0.124 0.157 0.101711395817 gnomAD-2.1.1 1.21E-05 None None None None I None 0 5.8E-05 None 0 0 None 3.27E-05 None 0 0 0
V/M 7994 Ig-65 10 rs779653609 0.0677 -0.301 0.003 N 0.124 0.157 0.101711395817 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 7994 Ig-65 10 rs779653609 0.0677 -0.301 0.003 N 0.124 0.157 0.101711395817 gnomAD-4.0.0 4.33947E-06 None None None None I None 1.33572E-05 3.335E-05 None 0 0 None 0 0 1.6959E-06 1.09818E-05 1.60123E-05
V/A 8087 Ig-66 10 rs764391944 0.105 -1.683 None N 0.107 0.304 0.292423486923 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.06E-06 0
V/A 8087 Ig-66 10 rs764391944 0.105 -1.683 None N 0.107 0.304 0.292423486923 gnomAD-4.0.0 1.59778E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86791E-06 0 0
V/E 8087 Ig-66 10 None 0.146 None 0.096 N 0.511 0.421 0.5353919603 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/E 8087 Ig-66 10 None 0.146 None 0.096 N 0.511 0.421 0.5353919603 gnomAD-4.0.0 6.57479E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47037E-05 0 0
V/L 8087 Ig-66 10 None 0.1067 None None N 0.121 0.271 0.1749357433 gnomAD-4.0.0 6.85513E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00497E-07 0 0
V/M 8087 Ig-66 10 None 0.0759 None 0.007 N 0.287 0.235 0.228597637076 gnomAD-4.0.0 6.85513E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00497E-07 0 0
F/S 8180 Ig-67 10 None 0.2646 None None N 0.239 0.286 0.549755530797 gnomAD-4.0.0 1.59299E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86203E-06 0 0
V/A 8273 Ig-68 10 None 0.1606 None 0.002 D 0.103 0.177 0.498705051145 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 8273 Ig-68 10 None 0.119 None 0.005 N 0.265 0.134 0.183819452728 gnomAD-4.0.0 1.61611E-06 None None None None N None 0 2.29474E-05 None 0 0 None 0 0 0 0 0
V/F 8369 Ig-69 10 rs755722481 0.1784 None 0.97 N 0.376 0.518 0.867213745552 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.1E-06 0
V/F 8369 Ig-69 10 rs755722481 0.1784 None 0.97 N 0.376 0.518 0.867213745552 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/F 8369 Ig-69 10 rs755722481 0.1784 None 0.97 N 0.376 0.518 0.867213745552 gnomAD-4.0.0 1.05641E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44341E-05 0 0
V/I 8369 Ig-69 10 rs755722481 0.0691 None 0.002 N 0.104 0.164 0.534140917371 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 8369 Ig-69 10 rs755722481 0.0691 None 0.002 N 0.104 0.164 0.534140917371 gnomAD-4.0.0 6.83558E-06 None None None None N None 0 0 None 0 0 None 0 0 8.49062E-06 0 1.6073E-05
V/G 8465 Ig-70 10 None 0.193 None 0.928 N 0.416 0.55 0.857228785163 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/M 8652 Ig-72 10 rs760452917 0.073 -0.43 0.001 N 0.107 0.139 0.0762999501168 gnomAD-2.1.1 1.17649E-04 None None None None N None 0 0 None 0 0 None 9.68474E-04 None 0 0 0
I/M 8652 Ig-72 10 rs760452917 0.073 -0.43 0.001 N 0.107 0.139 0.0762999501168 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.23182E-04 0
I/M 8652 Ig-72 10 rs760452917 0.073 -0.43 0.001 N 0.107 0.139 0.0762999501168 gnomAD-4.0.0 5.02958E-05 None None None None N None 0 0 None 0 0 None 0 0 8.48489E-07 8.5243E-04 4.81757E-05
I/V 8652 Ig-72 10 rs763953118 0.056 -0.625 None N 0.051 0.072 0.0954503805726 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
I/V 8652 Ig-72 10 rs763953118 0.056 -0.625 None N 0.051 0.072 0.0954503805726 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.92901E-04 None 0 0 1.47E-05 0 0
I/V 8652 Ig-72 10 rs763953118 0.056 -0.625 None N 0.051 0.072 0.0954503805726 gnomAD-4.0.0 3.10478E-06 None None None None N None 0 0 None 0 2.22906E-05 None 0 0 3.39402E-06 0 0
I/M 8745 Ig-73 10 rs2077168515 0.0708 None None N 0.131 0.153 0.151104730317 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/M 8745 Ig-73 10 rs2077168515 0.0708 None None N 0.131 0.153 0.151104730317 gnomAD-4.0.0 6.5716E-06 None None None None I None 2.41185E-05 0 None 0 0 None 0 0 0 0 0
I/T 8745 Ig-73 10 rs1176501015 0.08 0.164 None N 0.201 0.154 0.45349784317 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
I/T 8745 Ig-73 10 rs1176501015 0.08 0.164 None N 0.201 0.154 0.45349784317 gnomAD-4.0.0 1.5968E-06 None None None None I None 0 2.29137E-05 None 0 0 None 0 0 0 0 0
I/V 8745 Ig-73 10 rs901437058 0.0601 None None N 0.147 0.107 0.162503812791 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 1.92827E-04 None 0 0 1.47E-05 0 0
I/V 8745 Ig-73 10 rs901437058 0.0601 None None N 0.147 0.107 0.162503812791 gnomAD-4.0.0 1.31328E-05 None None None None I None 0 0 None 0 1.93274E-04 None 0 0 1.47029E-05 0 0
I/M 8839 Ig-74 10 None 0.07 None 0.001 N 0.133 0.107 0.171388866994 gnomAD-4.0.0 1.369E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99683E-07 0 1.65717E-05
I/T 8839 Ig-74 10 None 0.1657 None 0.001 N 0.179 0.184 0.665430918054 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 8839 Ig-74 10 None 0.0633 None None N 0.056 0.174 0.418718287753 gnomAD-4.0.0 2.05351E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69906E-06 0 0
T/R 8935 Ig-75 10 rs571245328 0.1334 -0.32 0.171 N 0.421 0.242 0.31411915649 gnomAD-2.1.1 1.93E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.57E-05 0
T/R 8935 Ig-75 10 rs571245328 0.1334 -0.32 0.171 N 0.421 0.242 0.31411915649 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
T/R 8935 Ig-75 10 rs571245328 0.1334 -0.32 0.171 N 0.421 0.242 0.31411915649 gnomAD-4.0.0 9.59104E-06 None None None None N None 0 0 None 0 0 None 0 0 1.30161E-05 0 0
M/V 9028 Ig-76 10 rs2076878438 0.0539 None 0.028 N 0.305 0.102 0.115124310173 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Y/C 9121 Ig-77 10 rs774681899 0.0874 0.118 0.975 N 0.222 0.344 0.589725459201 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
Y/C 9121 Ig-77 10 rs774681899 0.0874 0.118 0.975 N 0.222 0.344 0.589725459201 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/C 9121 Ig-77 10 rs774681899 0.0874 0.118 0.975 N 0.222 0.344 0.589725459201 gnomAD-4.0.0 1.30186E-05 None None None None I None 0 0 None 0 0 None 0 0 1.61084E-05 0 3.20451E-05
V/I 9214 Ig-78 10 rs987421243 0.0737 -0.025 0.489 N 0.419 0.114 0.319686207203 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
V/I 9214 Ig-78 10 rs987421243 0.0737 -0.025 0.489 N 0.419 0.114 0.319686207203 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 9214 Ig-78 10 rs987421243 0.0737 -0.025 0.489 N 0.419 0.114 0.319686207203 gnomAD-4.0.0 6.57462E-06 None None None None I None 2.41266E-05 0 None 0 0 None 0 0 0 0 0
V/I 9310 Ig-79 10 rs200207722 0.0611 -0.32 0.001 N 0.091 0.057 None gnomAD-2.1.1 8.58E-05 None None None None I None 0 2.84E-05 None 0 0 None 0 None 0 1.79893E-04 0
V/I 9310 Ig-79 10 rs200207722 0.0611 -0.32 0.001 N 0.091 0.057 None gnomAD-3.1.2 6.57E-05 None None None None I None 0 0 0 0 0 None 0 0 1.4699E-04 0 0
V/I 9310 Ig-79 10 rs200207722 0.0611 -0.32 0.001 N 0.091 0.057 None gnomAD-4.0.0 7.68987E-05 None None None None I None 0 3.3379E-05 None 0 0 None 3.12578E-05 0 9.16071E-05 0 1.92234E-04
V/M 9406 Ig-80 10 rs1280284347 0.1091 -0.286 0.009 None 0.334 0.135 0.31077124679 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/M 9406 Ig-80 10 rs1280284347 0.1091 -0.286 0.009 None 0.334 0.135 0.31077124679 gnomAD-4.0.0 1.59116E-06 None None None None N None 5.65355E-05 0 None 0 0 None 0 0 0 0 0
V/A 9503 Ig-81 11 None 0.219 None 0.165 None 0.333 0.329 0.568572517066 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 9503 Ig-81 11 rs202160275 0.0721 -0.111 0.001 None 0.077 0.122 None gnomAD-2.1.1 3.42705E-04 None None None None I None 0 6.79079E-04 None 4.34783E-03 0 None 6.54E-05 None 0 1.79334E-04 2.80899E-04
V/I 9503 Ig-81 11 rs202160275 0.0721 -0.111 0.001 None 0.077 0.122 None gnomAD-3.1.2 2.7604E-04 None None None None I None 2.41E-05 3.92876E-04 0 4.6083E-03 0 None 0 0 2.4986E-04 2.06954E-04 4.78469E-04
V/I 9503 Ig-81 11 rs202160275 0.0721 -0.111 0.001 None 0.077 0.122 None gnomAD-4.0.0 2.38629E-04 None None None None I None 2.67044E-05 5.1677E-04 None 4.59428E-03 0 None 0 6.25E-03 1.15273E-04 5.48992E-05 5.92379E-04
V/I 9599 Ig-82 10 rs887090503 0.0765 None 0.201 None 0.382 0.131 0.388334884743 gnomAD-4.0.0 1.36882E-06 None None None None N None 0 2.23624E-05 None 0 0 None 0 0 8.99735E-07 0 0
V/L 9599 Ig-82 10 rs887090503 0.1339 -0.281 0.002 None 0.065 0.196 0.312001716656 gnomAD-2.1.1 7.14E-06 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 7.81E-06 0
V/L 9599 Ig-82 10 rs887090503 0.1339 -0.281 0.002 None 0.065 0.196 0.312001716656 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 9599 Ig-82 10 rs887090503 0.1339 -0.281 0.002 None 0.065 0.196 0.312001716656 gnomAD-4.0.0 9.29766E-06 None None None None N None 1.33454E-05 0 None 0 0 None 0 0 1.18697E-05 0 0
I/N 9707 Ig-83 10 rs1484487083 0.7404 -1.077 0.794 None 0.455 0.376 0.789950293674 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 3.32E-05 None 0 0 0
I/N 9707 Ig-83 10 rs1484487083 0.7404 -1.077 0.794 None 0.455 0.376 0.789950293674 gnomAD-4.0.0 6.84899E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16428E-05 0
I/S 9707 Ig-83 10 None 0.6913 None 0.213 None 0.39 0.266 0.69243939542 gnomAD-4.0.0 6.84899E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00012E-07 0 0
I/T 9707 Ig-83 10 None 0.4873 None 0.351 None 0.351 0.191 0.656945041481 gnomAD-4.0.0 6.84899E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65832E-05
V/M 9998 Ig-85 10 rs1359452427 0.1655 -0.558 0.989 None 0.493 0.371 0.622397550212 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
I/T 13692 Ig-87 9 None 0.8882 None 1.0 D 0.72 0.622 0.810854131144 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 13790 Ig-88 11 None 0.5633 None 0.101 N 0.287 0.139 0.238096912614 gnomAD-4.0.0 1.37878E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80965E-06 0 0
V/G 13790 Ig-88 11 None 0.6219 None 0.351 N 0.648 0.142 0.397391247328 gnomAD-4.0.0 6.8939E-07 None None None None N None 0 0 None 0 0 None 1.88388E-05 0 0 0 0
Q/K 13883 Ig-89 8 None 0.6022 None 0.993 N 0.314 0.344 0.202086224978 gnomAD-4.0.0 1.62151E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.05979E-05
V/D 13974 Ig-90 10 None 0.946 None 1.0 D 0.864 0.47 0.729516068776 gnomAD-4.0.0 1.36881E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79928E-06 0 0
V/I 13974 Ig-90 10 rs373881831 0.1088 -0.235 0.992 N 0.54 0.221 None gnomAD-2.1.1 3.93E-05 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 0 None 0 6.26E-05 0
V/I 13974 Ig-90 10 rs373881831 0.1088 -0.235 0.992 N 0.54 0.221 None gnomAD-3.1.2 4.6E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 8.82E-05 0 0
V/I 13974 Ig-90 10 rs373881831 0.1088 -0.235 0.992 N 0.54 0.221 None gnomAD-4.0.0 3.34746E-05 None None None None N None 4.00695E-05 3.33522E-05 None 0 0 None 0 0 3.9846E-05 1.09815E-05 1.6019E-05
V/A 14063 Ig-91 10 rs772758022 0.5856 -1.448 0.989 D 0.443 0.463 0.676012115908 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/A 14063 Ig-91 10 rs772758022 0.5856 -1.448 0.989 D 0.443 0.463 0.676012115908 gnomAD-4.0.0 3.18445E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72037E-06 0 0
Q/E 14151 Ig-92 10 None 0.1427 None 0.953 D 0.441 0.295 0.409665357357 gnomAD-4.0.0 6.84503E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99716E-07 0 0
V/A 14328 Ig-94 10 None 0.2121 None 0.001 N 0.113 0.119 0.415055319159 gnomAD-4.0.0 3.18451E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7202E-06 0 0
V/G 14328 Ig-94 10 rs2060028786 0.3883 None 0.22 D 0.663 0.203 0.698599672906 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
V/G 14328 Ig-94 10 rs2060028786 0.3883 None 0.22 D 0.663 0.203 0.698599672906 gnomAD-4.0.0 6.57938E-06 None None None None N None 2.41534E-05 0 None 0 0 None 0 0 0 0 0
V/I 14417 Ig-95 10 rs906675886 0.0738 -0.129 0.997 N 0.504 0.295 None gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
V/I 14417 Ig-95 10 rs906675886 0.0738 -0.129 0.997 N 0.504 0.295 None gnomAD-4.0.0 1.02676E-05 None None None None N None 0 0 None 0 0 None 0 0 1.34948E-05 0 0
V/A 14506 Ig-96 10 rs1270698475 0.3915 -1.4 0.998 D 0.455 0.568 0.740382078105 gnomAD-2.1.1 4.33E-06 None None None None N None 0 0 None 0 0 None 3.64E-05 None 0 0 0
V/A 14506 Ig-96 10 rs1270698475 0.3915 -1.4 0.998 D 0.455 0.568 0.740382078105 gnomAD-4.0.0 1.62406E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.49943E-05 0
V/L 14684 Ig-98 10 rs2059719746 0.3725 None 0.959 N 0.438 0.225 0.327952845175 gnomAD-4.0.0 6.8445E-07 None None None None N None 0 2.23804E-05 None 0 0 None 0 0 0 0 0
V/M 14684 Ig-98 10 rs2059719746 0.1654 None 0.959 N 0.404 0.296 0.347659731818 gnomAD-4.0.0 1.3689E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79931E-06 0 0
V/I 14773 Ig-99 9 rs2059498760 0.0869 None 0.002 D 0.322 0.138 0.522717468363 gnomAD-4.0.0 1.59312E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0281E-05
Q/H 14862 Ig-100 10 None 0.5977 None 0.999 D 0.66 0.364 0.451599300725 gnomAD-4.0.0 6.84765E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00027E-07 0 0
Q/R 14862 Ig-100 10 None 0.1999 None 0.997 N 0.461 0.454 0.338834610459 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
I/M 15040 Ig-102 10 rs74580375 0.0789 -0.647 0.188 N 0.539 0.042 None gnomAD-2.1.1 1.07626E-03 None None None None N None 1.66044E-04 0 None 0 1.42051E-02 None 5.57706E-04 None 0 1.59E-05 4.26743E-04
I/M 15040 Ig-102 10 rs74580375 0.0789 -0.647 0.188 N 0.539 0.042 None gnomAD-3.1.2 6.32053E-04 None None None None N None 7.24E-05 1.3132E-04 0 0 1.5181E-02 None 0 0 4.42E-05 2.07211E-03 0
I/M 15040 Ig-102 10 rs74580375 0.0789 -0.647 0.188 N 0.539 0.042 None 1000 genomes 3.79393E-03 None None None None N None 0 0 None None 1.59E-02 0 None None None 3.1E-03 None
I/M 15040 Ig-102 10 rs74580375 0.0789 -0.647 0.188 N 0.539 0.042 None gnomAD-4.0.0 3.92098E-04 None None None None N None 8.00876E-05 5.01689E-05 None 0 1.08159E-02 None 0 0 2.03577E-05 7.03668E-04 8.49986E-04
I/T 15040 Ig-102 10 rs1334750715 0.0785 None 0.117 N 0.506 0.201 0.592052101994 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 1.94932E-04 None 0 0 0 0 0
I/T 15040 Ig-102 10 rs1334750715 0.0785 None 0.117 N 0.506 0.201 0.592052101994 gnomAD-4.0.0 2.48169E-06 None None None None N None 1.33518E-05 0 None 0 2.24437E-05 None 0 0 0 1.09953E-05 1.60385E-05
T/I 15217 Ig-104 10 None 0.1126 None 0.896 N 0.375 0.188 0.422160833541 gnomAD-4.0.0 3.18912E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72574E-06 0 0
I/S 15311 Ig-105 10 None 0.3127 None 0.994 D 0.549 0.439 0.786388363908 gnomAD-4.0.0 6.85409E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00481E-07 0 0
I/T 15311 Ig-105 10 rs769964778 0.1344 -2.253 0.961 N 0.523 0.312 0.682452046549 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 4.69E-05 0 0
I/T 15311 Ig-105 10 rs769964778 0.1344 -2.253 0.961 N 0.523 0.312 0.682452046549 gnomAD-4.0.0 6.85409E-07 None None None None N None 0 0 None 0 0 None 1.87751E-05 0 0 0 0
Q/H 15400 Ig-106 10 rs745948750 0.6728 -1.048 0.999 D 0.655 0.424 0.509346181843 gnomAD-2.1.1 4.31E-06 None None None None N None 0 0 None 0 0 None 3.85E-05 None 0 0 0
Q/H 15400 Ig-106 10 rs745948750 0.6728 -1.048 0.999 D 0.655 0.424 0.509346181843 gnomAD-4.0.0 1.65636E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.53445E-05 0
Q/K 15400 Ig-106 10 rs2154210935 0.1469 None 0.997 N 0.441 0.416 0.37262878642 gnomAD-4.0.0 1.39075E-06 None None None None N None 0 0 None 0 0 None 0 0 9.09988E-07 1.22023E-05 0
Q/L 15400 Ig-106 10 None 0.3334 None 0.997 N 0.596 0.467 0.550047086221 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
L/I 16268 Ig-110 7 rs1474027032 0.0808 None 0.004 N 0.266 0.074 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
L/I 16268 Ig-110 7 rs1474027032 0.0808 None 0.004 N 0.266 0.074 None gnomAD-4.0.0 5.83361E-05 None None None None N None 1.33826E-05 0 None 0 0 None 0 0 7.71986E-05 0 3.20914E-05
I/T 16964 Ig-111 10 rs794729453 0.3516 -2.163 0.891 N 0.459 0.426 0.822854388619 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
I/T 16964 Ig-111 10 rs794729453 0.3516 -2.163 0.891 N 0.459 0.426 0.822854388619 gnomAD-4.0.0 8.21683E-06 None None None None I None 0 0 None 0 0 None 0 1.73853E-04 9.89855E-06 0 0
I/V 16964 Ig-111 10 rs1487972631 0.091 None 0.267 N 0.303 0.037 0.508637063495 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 17682 Ig-113 6 None 0.7886 None 0.051 N 0.26 0.311 0.655104906463 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
I/N 17976 Ig-114 9 rs1293562368 0.9518 None 0.999 N 0.687 0.657 0.868386450272 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/N 17976 Ig-114 9 rs1293562368 0.9518 None 0.999 N 0.687 0.657 0.868386450272 gnomAD-4.0.0 6.58189E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47223E-05 0 0
I/T 17976 Ig-114 9 rs1293562368 0.8951 None 0.998 N 0.512 0.573 0.72263772115 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 17976 Ig-114 9 rs1293562368 0.8951 None 0.998 N 0.512 0.573 0.72263772115 gnomAD-4.0.0 6.58189E-06 None None None None N None 2.41488E-05 0 None 0 0 None 0 0 0 0 0
I/V 17976 Ig-114 9 rs371424482 0.1089 -0.806 0.889 N 0.307 0.191 None gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
I/V 17976 Ig-114 9 rs371424482 0.1089 -0.806 0.889 N 0.307 0.191 None gnomAD-3.1.2 1.98E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 0 0 0
I/V 17976 Ig-114 9 rs371424482 0.1089 -0.806 0.889 N 0.307 0.191 None gnomAD-4.0.0 8.12176E-06 None None None None N None 1.39889E-04 0 None 0 0 None 0 0 0 0 0
M/I 18694 Ig-116 7 rs566224052 0.3162 -0.772 0.454 N 0.427 0.147 0.337378238328 gnomAD-2.1.1 4.25E-06 None None None None N None 6.65E-05 0 None 0 0 None 0 None 0 0 0
M/I 18694 Ig-116 7 rs566224052 0.3162 -0.772 0.454 N 0.427 0.147 0.337378238328 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
M/I 18694 Ig-116 7 rs566224052 0.3162 -0.772 0.454 N 0.427 0.147 0.337378238328 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
M/I 18694 Ig-116 7 rs566224052 0.3162 -0.772 0.454 N 0.427 0.147 0.337378238328 gnomAD-4.0.0 2.61243E-06 None None None None N None 1.71833E-05 0 None 0 2.45218E-05 None 0 0 0 0 0
M/T 18694 Ig-116 7 rs2052797392 0.1869 None 0.891 N 0.404 0.455 0.787786449039 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 18694 Ig-116 7 rs2052797392 0.1869 None 0.891 N 0.404 0.455 0.787786449039 gnomAD-4.0.0 1.25081E-06 None None None None N None 0 0 None 0 0 None 0 0 1.70342E-06 0 0
I/T 19102 Ig-117 8 rs878854319 0.7963 -2.151 1.0 N 0.691 0.547 0.785196952754 gnomAD-4.0.0 1.59256E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
L/F 19396 Ig-118 6 rs1277629300 0.1925 -1.239 0.638 D 0.585 0.176 0.610090021501 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 0 0
L/F 19396 Ig-118 6 rs1277629300 0.1925 -1.239 0.638 D 0.585 0.176 0.610090021501 gnomAD-4.0.0 1.36879E-06 None None None None N None 0 2.23884E-05 None 0 0 None 0 0 8.99577E-07 0 0
L/P 19396 Ig-118 6 rs1217157718 0.9334 -1.352 0.916 N 0.72 0.603 0.878231333192 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/P 19396 Ig-118 6 rs1217157718 0.9334 -1.352 0.916 N 0.72 0.603 0.878231333192 gnomAD-4.0.0 2.7376E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63908E-05 0
L/H 20088 Ig-120 9 rs747560869 0.762 -1.241 1.0 N 0.711 0.569 0.901459665828 gnomAD-2.1.1 4.4E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.39E-06 0
L/H 20088 Ig-120 9 rs747560869 0.762 -1.241 1.0 N 0.711 0.569 0.901459665828 gnomAD-4.0.0 6.95384E-07 None None None None N None 0 0 None 0 0 None 0 0 9.05984E-07 0 0
L/P 20088 Ig-120 9 rs747560869 0.9659 None 0.999 D 0.725 0.657 0.908644682553 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 20088 Ig-120 9 rs747560869 0.9659 None 0.999 D 0.725 0.657 0.908644682553 gnomAD-4.0.0 2.51552E-06 None None None None N None 0 0 None 0 0 None 0 0 3.41367E-06 0 0
L/V 20088 Ig-120 9 rs769097181 0.1604 -0.862 0.9 N 0.281 0.22 0.648878273322 gnomAD-2.1.1 2.65E-05 None None None None N None 0 0 None 0 0 None 2.36165E-04 None 0 0 0
L/V 20088 Ig-120 9 rs769097181 0.1604 -0.862 0.9 N 0.281 0.22 0.648878273322 gnomAD-4.0.0 1.80914E-05 None None None None N None 0 0 None 0 0 None 0 0 0 3.19819E-04 0
V/A 21184 Ig-123 8 rs747755332 0.5374 -1.579 0.954 N 0.496 0.528 0.668205050051 gnomAD-2.1.1 4.08E-06 None None None None I None 0 2.93E-05 None 0 0 None 0 None 0 0 0
V/A 21184 Ig-123 8 rs747755332 0.5374 -1.579 0.954 N 0.496 0.528 0.668205050051 gnomAD-4.0.0 6.86302E-07 None None None None I None 0 2.24992E-05 None 0 0 None 0 0 0 0 0
V/D 21184 Ig-123 8 None 0.9029 None 0.998 D 0.687 0.737 0.907794322601 gnomAD-4.0.0 6.86302E-07 None None None None I None 0 0 None 0 0 None 0 0 9.01756E-07 0 0
V/I 21184 Ig-123 8 rs1290013861 0.0987 None 0.835 N 0.457 0.217 0.471941563831 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/I 21184 Ig-123 8 rs1290013861 0.0987 None 0.835 N 0.457 0.217 0.471941563831 gnomAD-4.0.0 3.10797E-06 None None None None I None 0 0 None 0 0 None 0 0 4.24897E-06 0 0
I/L 21476 Ig-124 8 rs898981554 0.1147 -0.372 0.084 N 0.249 0.064 0.267755039894 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9E-06 0
I/L 21476 Ig-124 8 rs898981554 0.1147 -0.372 0.084 N 0.249 0.064 0.267755039894 gnomAD-4.0.0 2.05911E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70343E-06 0 0
L/F 22271 Ig-126 7 rs2047464424 0.4565 None 0.056 N 0.401 0.243 0.568285537894 gnomAD-4.0.0 2.73965E-06 None None None None I None 0 0 None 0 0 None 1.87568E-05 0 1.79993E-06 0 1.6587E-05
L/I 22271 Ig-126 7 rs2047464424 0.1279 None 0.805 N 0.481 0.128 0.527908583987 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/I 22271 Ig-126 7 rs2047464424 0.1279 None 0.805 N 0.481 0.128 0.527908583987 gnomAD-4.0.0 6.57471E-06 None None None None I None 2.41266E-05 0 None 0 0 None 0 0 0 0 0
L/R 22271 Ig-126 7 None 0.6916 None 0.983 N 0.648 0.716 0.812904552971 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
L/V 22271 Ig-126 7 None 0.1371 None 0.025 N 0.401 0.091 0.467074840246 gnomAD-4.0.0 6.84913E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16325E-05 0
L/P 23354 Ig-129 10 None 0.9832 None 0.994 N 0.832 0.704 0.864877026976 gnomAD-4.0.0 1.59181E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85948E-06 0 0
L/R 23354 Ig-129 10 None 0.7895 None 0.976 N 0.801 0.626 0.828681824056 gnomAD-4.0.0 1.59181E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85948E-06 0 0
V/A 23643 Ig-130 7 None 0.5132 None 0.892 D 0.441 0.547 0.656813955947 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 23643 Ig-130 7 rs1249962970 0.0814 0.015 0.63 N 0.512 0.145 0.524792858863 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
V/I 23643 Ig-130 7 rs1249962970 0.0814 0.015 0.63 N 0.512 0.145 0.524792858863 gnomAD-4.0.0 6.37473E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.74119E-05 0
V/G 24039 Ig-131 11 None 0.4259 None 0.667 D 0.525 0.546 0.884044859232 gnomAD-4.0.0 2.05312E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69877E-06 0 0
I/T 25121 Ig-134 11 rs751021006 0.229 -1.578 0.062 N 0.49 0.298 0.672509336206 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
I/T 25121 Ig-134 11 rs751021006 0.229 -1.578 0.062 N 0.49 0.298 0.672509336206 gnomAD-4.0.0 1.59168E-06 None None None None N None 0 0 None 0 2.77439E-05 None 0 0 0 0 0
I/V 25121 Ig-134 11 rs199508062 0.0624 -0.804 None N 0.096 0.06 None gnomAD-2.1.1 1.14367E-04 None None None None N None 1.24039E-03 2.83E-05 None 0 0 None 0 None 0 0 1.40528E-04
I/V 25121 Ig-134 11 rs199508062 0.0624 -0.804 None N 0.096 0.06 None gnomAD-3.1.2 3.28774E-04 None None None None N None 1.20715E-03 0 0 0 0 None 0 0 0 0 0
I/V 25121 Ig-134 11 rs199508062 0.0624 -0.804 None N 0.096 0.06 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
I/V 25121 Ig-134 11 rs199508062 0.0624 -0.804 None N 0.096 0.06 None gnomAD-4.0.0 6.01155E-05 None None None None N None 1.24013E-03 3.33333E-05 None 0 0 None 0 0 8.47738E-07 0 1.60092E-05
I/T 25520 Ig-135 7 rs1553601714 0.43 None 0.22 N 0.641 0.365 0.665058716224 gnomAD-4.0.0 1.36904E-06 None None None None I None 0 0 None 0 2.53024E-05 None 0 0 8.99666E-07 0 0
Y/C 25807 Ig-136 10 rs774704941 0.2086 -0.97 0.999 N 0.611 0.47 0.645716986391 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
Y/C 25807 Ig-136 10 rs774704941 0.2086 -0.97 0.999 N 0.611 0.47 0.645716986391 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85977E-06 0 0
I/T 26203 Ig-137 11 rs766839297 0.3235 None 0.684 N 0.439 0.423 0.70159519113 gnomAD-4.0.0 1.59545E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44155E-05 0
I/T 26602 Ig-138 9 rs1165543503 0.562 -1.32 0.822 D 0.541 0.471 0.780957376407 gnomAD-2.1.1 7.14E-06 None None None None I None 0 5.66E-05 None 0 0 None 0 None 0 0 0
I/T 26602 Ig-138 9 rs1165543503 0.562 -1.32 0.822 D 0.541 0.471 0.780957376407 gnomAD-3.1.2 1.32E-05 None None None None I None 0 1.31337E-04 0 0 0 None 0 0 0 0 0
I/T 26602 Ig-138 9 rs1165543503 0.562 -1.32 0.822 D 0.541 0.471 0.780957376407 gnomAD-4.0.0 3.84455E-06 None None None None I None 0 5.08802E-05 None 0 0 None 0 0 0 0 0
Y/C 26889 Ig-139 10 rs571328201 0.1798 -1.299 1.0 N 0.727 0.4 None gnomAD-2.1.1 1.17934E-04 None None None None N None 4.14E-05 2.84E-05 None 0 0 None 0 None 0 2.42218E-04 0
Y/C 26889 Ig-139 10 rs571328201 0.1798 -1.299 1.0 N 0.727 0.4 None gnomAD-3.1.2 1.24913E-04 None None None None N None 7.24E-05 0 0 0 0 None 0 0 2.35315E-04 0 0
Y/C 26889 Ig-139 10 rs571328201 0.1798 -1.299 1.0 N 0.727 0.4 None gnomAD-4.0.0 1.20255E-04 None None None None N None 4.00759E-05 1.669E-05 None 3.38066E-05 0 None 7.81226E-05 0 1.53442E-04 0 4.80523E-05
Y/F 26889 Ig-139 10 rs571328201 0.0776 -0.768 0.117 N 0.317 0.166 0.322786055943 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
Y/F 26889 Ig-139 10 rs571328201 0.0776 -0.768 0.117 N 0.317 0.166 0.322786055943 gnomAD-4.0.0 2.73761E-06 None None None None N None 0 0 None 0 0 None 0 0 3.5984E-06 0 0
F/S 27972 Ig-142 10 rs1703936527 0.8152 None 0.815 N 0.381 0.313 0.61599129918 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/F 28367 Ig-143 10 None 0.2209 None 0.175 N 0.29 0.205 0.328486982098 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 28367 Ig-143 10 rs1199614118 0.1697 -0.802 0.081 D 0.312 0.39 0.711956708817 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/T 28367 Ig-143 10 rs1199614118 0.1697 -0.802 0.081 D 0.312 0.39 0.711956708817 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 28367 Ig-143 10 rs1199614118 0.1697 -0.802 0.081 D 0.312 0.39 0.711956708817 gnomAD-4.0.0 3.84294E-06 None None None None I None 0 0 None 0 0 None 0 0 7.17844E-06 0 0
I/V 28367 Ig-143 10 None 0.0775 None None N 0.125 0.083 0.298745278005 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
L/V 28764 Ig-144 10 None 0.1015 None 0.63 N 0.51 0.117 0.324986149311 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
V/A 29054 Ig-145 10 rs771605613 0.2883 -1.276 0.37 N 0.239 0.353 0.632176559189 gnomAD-2.1.1 1.22E-05 None None None None I None 0 2.94E-05 None 0 0 None 0 None 0 1.79E-05 0
V/A 29054 Ig-145 10 rs771605613 0.2883 -1.276 0.37 N 0.239 0.353 0.632176559189 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 29054 Ig-145 10 rs771605613 0.2883 -1.276 0.37 N 0.239 0.353 0.632176559189 gnomAD-4.0.0 2.48183E-05 None None None None I None 0 1.67954E-05 None 0 0 None 0 0 3.2218E-05 0 1.60277E-05
V/I 29054 Ig-145 10 rs757488542 0.0794 -0.052 0.973 N 0.479 0.339 0.677721526675 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.99E-06 0
V/I 29054 Ig-145 10 rs757488542 0.0794 -0.052 0.973 N 0.479 0.339 0.677721526675 gnomAD-4.0.0 4.79273E-06 None None None None I None 0 4.63607E-05 None 0 0 None 0 0 2.86161E-06 0 0
V/F 29849 Ig-147 8 rs727504493 0.1613 None 0.062 N 0.459 0.323 0.319114376414 gnomAD-4.0.0 4.14362E-06 None None None None I None 0 0 None 0 0 None 0 0 5.41946E-06 0 0
V/L 29849 Ig-147 8 None 0.1608 None 0.004 N 0.282 0.183 0.0884992946249 gnomAD-4.0.0 6.90603E-07 None None None None I None 0 0 None 0 0 None 0 0 9.03243E-07 0 0
V/I 30141 Ig-148 10 None 0.075 None None N 0.103 0.11 0.326074293725 gnomAD-4.0.0 1.37028E-06 None None None None I None 0 0 None 0 0 None 0 0 9.00748E-07 1.16015E-05 0
L/F 30536 Ig-149 5 rs1177911560 0.1348 -0.647 0.497 N 0.553 0.186 0.0762999501168 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
L/F 30536 Ig-149 5 rs1177911560 0.1348 -0.647 0.497 N 0.553 0.186 0.0762999501168 gnomAD-4.0.0 1.59241E-06 None None None None I None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
H/L 30935 Ig-150 9 None 0.175 None 1.0 N 0.704 0.498 0.690638299042 gnomAD-4.0.0 1.59358E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85807E-06 0 0
H/Q 30935 Ig-150 9 None 0.4552 None 1.0 N 0.584 0.366 0.218112801441 gnomAD-4.0.0 3.42314E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49725E-06 0 0
I/T 31225 Ig-151 8 rs727505175 0.8134 -1.808 0.939 N 0.616 0.621 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.66E-05 0
I/T 31225 Ig-151 8 rs727505175 0.8134 -1.808 0.939 N 0.616 0.621 None gnomAD-3.1.2 3.29E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 5.88E-05 0 0
I/T 31225 Ig-151 8 rs727505175 0.8134 -1.808 0.939 N 0.616 0.621 None gnomAD-4.0.0 5.32957E-05 None None None None I None 1.3349E-05 1.66778E-05 None 0 0 None 0 0 6.86571E-05 0 4.80307E-05
I/V 31225 Ig-151 8 rs529500497 0.1179 -0.867 0.02 N 0.236 0.082 0.554558929491 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.67616E-04 None 0 None 0 0 0
I/V 31225 Ig-151 8 rs529500497 0.1179 -0.867 0.02 N 0.236 0.082 0.554558929491 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 5.7759E-04 None 0 0 0 0 0
I/V 31225 Ig-151 8 rs529500497 0.1179 -0.867 0.02 N 0.236 0.082 0.554558929491 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
I/V 31225 Ig-151 8 rs529500497 0.1179 -0.867 0.02 N 0.236 0.082 0.554558929491 gnomAD-4.0.0 4.95732E-06 None None None None I None 0 0 None 0 1.56104E-04 None 0 0 8.47624E-07 0 0
V/I 31625 Ig-152 5 rs1697179878 0.0873 None 0.17 N 0.229 0.144 0.464098490096 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 31625 Ig-152 5 rs1697179878 0.0873 None 0.17 N 0.229 0.144 0.464098490096 gnomAD-4.0.0 6.57358E-06 None None None None I None 2.41394E-05 0 None 0 0 None 0 0 0 0 0
I/S 32316 Ig-154 10 None 0.5971 None 0.101 N 0.349 0.359 0.79540345994 gnomAD-4.0.0 6.84562E-07 None None None None I None 0 2.23644E-05 None 0 0 None 0 0 0 0 0
I/T 32316 Ig-154 10 rs1366924258 0.4484 None 0.183 N 0.362 0.242 0.605748623547 gnomAD-4.0.0 6.84562E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00001E-07 0 0
I/V 32316 Ig-154 10 None 0.0781 None None N 0.119 0.068 0.464183351471 gnomAD-4.0.0 1.59336E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86402E-06 0 0
V/I 33110 Ig-156 10 rs765303215 0.0778 -0.53 0.006 N 0.316 0.149 0.342168650903 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
V/I 33110 Ig-156 10 rs765303215 0.0778 -0.53 0.006 N 0.316 0.149 0.342168650903 gnomAD-4.0.0 1.59338E-06 None None None None N None 0 0 None 0 2.775E-05 None 0 0 0 0 0
Y/D 33206 Ig-157 4 None 0.8826 None 1.0 N 0.76 0.543 0.584023569625 gnomAD-4.0.0 3.18333E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71785E-06 0 0
Y/H 33206 Ig-157 4 None 0.6165 None 1.0 N 0.653 0.459 0.321393169273 gnomAD-4.0.0 1.59167E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
V/A 34146 Ig-160 10 rs1690411709 0.1567 None 0.027 N 0.367 0.13 0.612226609336 gnomAD-4.0.0 6.84154E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99412E-07 0 0
V/F 34146 Ig-160 10 None 0.2007 None None N 0.191 0.157 0.67588895853 gnomAD-4.0.0 1.36831E-06 None None None None I None 0 0 None 0 0 None 1.87273E-05 0 8.99416E-07 0 0
V/G 34146 Ig-160 10 rs1690411709 0.3257 None 0.117 D 0.421 0.204 0.672922844732 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/G 34146 Ig-160 10 rs1690411709 0.3257 None 0.117 D 0.421 0.204 0.672922844732 gnomAD-4.0.0 1.23933E-06 None None None None I None 1.33543E-05 0 None 0 0 None 0 0 8.47562E-07 0 0
V/I 34146 Ig-160 10 rs1690412972 0.0827 None None N 0.103 0.132 0.470890129789 gnomAD-4.0.0 6.84156E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
V/L 34146 Ig-160 10 None 0.2299 None 0.004 N 0.283 0.139 0.524533156562 gnomAD-4.0.0 6.84156E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99416E-07 0 0
K/E 34267 Ig-161 10 rs1690256257 0.4734 None 0.09 N 0.381 0.2 None gnomAD-4.0.0 1.591E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85775E-06 0 0
K/M 34267 Ig-161 10 rs879206062 0.4687 -0.254 0.912 N 0.456 0.348 0.335414705075 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
K/M 34267 Ig-161 10 rs879206062 0.4687 -0.254 0.912 N 0.456 0.348 0.335414705075 gnomAD-4.0.0 6.84167E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99429E-07 0 0
K/R 34267 Ig-161 10 rs879206062 0.0876 None None N 0.057 0.093 None gnomAD-4.0.0 2.0525E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69829E-06 0 0
M/T 35138 Ig-164 10 rs771741670 0.2996 -0.29 0.001 N 0.286 0.292 None gnomAD-2.1.1 2.5E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 4.68E-05 0
M/T 35138 Ig-164 10 rs771741670 0.2996 -0.29 0.001 N 0.286 0.292 None gnomAD-3.1.2 4.6E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 5.88E-05 0 0
M/T 35138 Ig-164 10 rs771741670 0.2996 -0.29 0.001 N 0.286 0.292 None gnomAD-4.0.0 7.00186E-05 None None None None N None 6.67343E-05 0 None 0 0 None 0 0 8.56021E-05 0 1.12068E-04
M/V 35138 Ig-164 10 rs368992068 0.0721 -0.387 None N 0.053 0.137 None gnomAD-2.1.1 1.2E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.86E-06 1.65399E-04
M/V 35138 Ig-164 10 rs368992068 0.0721 -0.387 None N 0.053 0.137 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 2.88351E-04 0 None 0 0 1.47E-05 0 0
M/V 35138 Ig-164 10 rs368992068 0.0721 -0.387 None N 0.053 0.137 None gnomAD-4.0.0 9.91398E-06 None None None None N None 0 1.66661E-05 None 1.01338E-04 0 None 0 0 9.32295E-06 0 1.60087E-05
T/A 35429 Ig-166 10 None 0.0944 None 0.037 N 0.323 0.054 0.21279746466 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 35429 Ig-166 10 rs1241466221 0.135 None 0.002 N 0.219 0.137 0.320256813643 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 35429 Ig-166 10 rs1241466221 0.135 None 0.002 N 0.219 0.137 0.320256813643 gnomAD-4.0.0 6.56961E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
T/K 35429 Ig-166 10 rs1241466221 0.2013 -0.474 0.001 N 0.297 0.251 0.352476196916 gnomAD-2.1.1 2.01E-05 None None None None N None 0 1.44852E-04 None 0 0 None 0 None 0 0 0
T/K 35429 Ig-166 10 rs1241466221 0.2013 -0.474 0.001 N 0.297 0.251 0.352476196916 gnomAD-4.0.0 7.95484E-06 None None None None N None 0 1.14317E-04 None 0 0 None 0 0 0 0 0
T/S 35429 Ig-166 10 rs878963350 0.1484 None 0.157 N 0.373 0.07 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
T/S 35429 Ig-166 10 rs878963350 0.1484 None 0.157 N 0.373 0.07 None gnomAD-4.0.0 1.3137E-05 None None None None N None 4.82323E-05 0 None 0 0 None 0 0 0 0 0
M/R 35616 Ig-167 10 None 0.3101 None 0.975 N 0.34 0.45 0.680782376918 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/T 35616 Ig-167 10 None 0.3734 None 0.425 N 0.297 0.324 0.668779650676 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/V 35616 Ig-167 10 None 0.1451 None 0.002 N 0.08 0.208 0.435043484731 gnomAD-4.0.0 1.36828E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0
Q/P 35711 Ig-168 10 None 0.8973 None 0.999 N 0.619 0.62 0.572347844689 gnomAD-4.0.0 1.20058E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31276E-06 0 0
I/N 35906 Ig-169 10 None 0.8904 None 0.997 N 0.673 0.582 0.892327293303 gnomAD-4.0.0 6.8735E-07 None None None -1.291(OBSL1) -0.74(OBSCN) N None 0 0 None 0 0 None 0 0 9.03377E-07 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.