Structural position:

  • Domain Type: Ig
  • Aligned Position: 18
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A'

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
L/R 18 Ig-1 13 rs748322000 0.3069 -0.002 1.0 N 0.719 0.593 None gnomAD-2.1.1 7.08E-06 None None None -1.227(TCAP) N None 8.01E-05 0 None 0 0 None 0 None 0 0 0
L/R 18 Ig-1 13 rs748322000 0.3069 -0.002 1.0 N 0.719 0.593 None gnomAD-3.1.2 2.63E-05 None None None -1.227(TCAP) N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
L/R 18 Ig-1 13 rs748322000 0.3069 -0.002 1.0 N 0.719 0.593 None gnomAD-4.0.0 7.68421E-06 None None None -1.227(TCAP) N None 1.01461E-04 0 None 0 0 None 0 0 0 0 0
R/T 116 Ig-2 13 rs569775318 0.6192 -0.982 0.141 N 0.496 0.36 0.40017627803 gnomAD-2.1.1 4.01E-06 None None None -0.028(TCAP) N None 0 0 None 0 5.44E-05 None 0 None 0 0 0
R/T 116 Ig-2 13 rs569775318 0.6192 -0.982 0.141 N 0.496 0.36 0.40017627803 gnomAD-3.1.2 2.63E-05 None None None -0.028(TCAP) N None 0 0 0 0 7.69823E-04 None 0 0 0 0 0
R/T 116 Ig-2 13 rs569775318 0.6192 -0.982 0.141 N 0.496 0.36 0.40017627803 1000 genomes 1.99681E-04 None None None -0.028(TCAP) N None 0 0 None None 1E-03 0 None None None 0 None
R/T 116 Ig-2 13 rs569775318 0.6192 -0.982 0.141 N 0.496 0.36 0.40017627803 gnomAD-4.0.0 2.97707E-05 None None None -0.028(TCAP) N None 0 0 None 0 1.04761E-03 None 0 0 8.4826E-07 0 0
I/L 955 Ig-3 13 rs762556628 0.1678 -0.01 0.007 N 0.213 0.06 0.346315397577 gnomAD-2.1.1 4E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.83E-06 0
I/V 955 Ig-3 13 rs762556628 0.084 -0.079 None N 0.159 0.079 0.422883881359 gnomAD-2.1.1 4E-06 None None None None I None 6.38E-05 0 None 0 0 None 0 None 0 0 0
I/V 955 Ig-3 13 rs762556628 0.084 -0.079 None N 0.159 0.079 0.422883881359 gnomAD-4.0.0 4.80134E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25007E-06 0 0
V/L 1094 Ig-4 13 None 0.1659 None 0.034 N 0.477 0.088 0.214338557667 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
L/I 1303 Ig-5 13 None 0.1186 None 0.033 N 0.405 0.054 0.421920138742 gnomAD-4.0.0 1.36846E-06 None None None None I None 0 0 None 0 0 None 0 1.73491E-04 0 0 1.65612E-05
L/P 1303 Ig-5 13 rs1407839718 0.3275 -0.327 0.912 N 0.483 0.576 0.813802140646 gnomAD-2.1.1 4E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 0 0
L/P 1303 Ig-5 13 rs1407839718 0.3275 -0.327 0.912 N 0.483 0.576 0.813802140646 gnomAD-4.0.0 1.36846E-06 None None None None I None 0 0 None 0 5.04414E-05 None 0 0 0 0 0
L/S 1469 Ig-6 13 rs1421828840 0.1118 -0.305 None N 0.282 0.276 0.57165941983 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14916E-04 0 None 0 0 None 0 None 0 0 0
L/S 1469 Ig-6 13 rs1421828840 0.1118 -0.305 None N 0.282 0.276 0.57165941983 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/S 1469 Ig-6 13 rs1421828840 0.1118 -0.305 None N 0.282 0.276 0.57165941983 gnomAD-4.0.0 6.57022E-06 None None None None I None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
K/E 1568 Ig-7 13 None 0.2557 None 0.999 N 0.713 0.477 0.404733080969 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 1568 Ig-7 13 rs1392098085 0.6206 0.192 1.0 N 0.708 0.312 0.292787519742 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
K/R 1568 Ig-7 13 None 0.0828 None 0.999 N 0.647 0.274 0.53534322723 gnomAD-4.0.0 6.84115E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99326E-07 0 0
K/T 1568 Ig-7 13 rs1331457272 0.2571 -0.095 1.0 N 0.665 0.526 0.436671004673 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/T 1568 Ig-7 13 rs1331457272 0.2571 -0.095 1.0 N 0.665 0.526 0.436671004673 gnomAD-4.0.0 6.84115E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
L/F 1853 Ig-9 13 rs778377360 0.2735 -0.749 0.046 N 0.355 0.25 0.534955811369 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
L/F 1853 Ig-9 13 rs778377360 0.2735 -0.749 0.046 N 0.355 0.25 0.534955811369 gnomAD-4.0.0 1.36824E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99308E-07 0 1.65585E-05
L/P 1853 Ig-9 13 None 0.619 None 0.997 N 0.713 0.695 0.817510992187 gnomAD-4.0.0 3.18144E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71318E-06 0 0
L/V 1853 Ig-9 13 rs778377360 0.1722 -0.416 0.939 N 0.582 0.188 0.54294064856 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
L/V 1853 Ig-9 13 rs778377360 0.1722 -0.416 0.939 N 0.582 0.188 0.54294064856 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/V 1853 Ig-9 13 rs778377360 0.1722 -0.416 0.939 N 0.582 0.188 0.54294064856 gnomAD-4.0.0 1.23922E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69492E-06 0 0
G/C 2090 Ig-10 13 rs752147588 0.2506 -0.885 0.997 N 0.511 0.358 0.672852936461 gnomAD-2.1.1 7.19E-05 None None None None N None 0 0 None 0 0 None 5.87966E-04 None 0 0 0
G/C 2090 Ig-10 13 rs752147588 0.2506 -0.885 0.997 N 0.511 0.358 0.672852936461 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
G/C 2090 Ig-10 13 rs752147588 0.2506 -0.885 0.997 N 0.511 0.358 0.672852936461 gnomAD-4.0.0 4.02738E-05 None None None None N None 0 0 None 0 0 None 0 0 0 6.91624E-04 3.20082E-05
G/D 2090 Ig-10 13 rs1199041868 0.2594 -0.572 0.891 N 0.391 0.349 0.265929055128 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
G/S 2090 Ig-10 13 rs752147588 0.0743 -0.487 0.454 N 0.331 0.214 0.163833314356 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 4.62E-05 0 0
G/S 2090 Ig-10 13 rs752147588 0.0743 -0.487 0.454 N 0.331 0.214 0.163833314356 gnomAD-4.0.0 2.73636E-06 None None None None N None 0 0 None 0 0 None 5.61651E-05 0 8.993E-07 0 0
P/A 2279 Ig-12 13 rs143679901 0.2773 -1.32 0.865 N 0.551 0.356 None gnomAD-2.1.1 7.98E-06 None None None None N None 1.23198E-04 0 None 0 0 None 0 None 0 0 0
P/A 2279 Ig-12 13 rs143679901 0.2773 -1.32 0.865 N 0.551 0.356 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
P/A 2279 Ig-12 13 rs143679901 0.2773 -1.32 0.865 N 0.551 0.356 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
P/A 2279 Ig-12 13 rs143679901 0.2773 -1.32 0.865 N 0.551 0.356 None gnomAD-4.0.0 4.33832E-06 None None None None N None 6.66649E-05 0 None 0 0 None 0 0 0 0 3.20041E-05
C/F 2368 Ig-13 13 None 0.5627 None 1.0 N 0.736 0.568 0.807600315609 gnomAD-4.0.0 1.59067E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02151E-05
C/G 2368 Ig-13 13 rs1205174155 0.5766 -0.964 1.0 N 0.739 0.668 0.848466065415 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
C/G 2368 Ig-13 13 rs1205174155 0.5766 -0.964 1.0 N 0.739 0.668 0.848466065415 gnomAD-4.0.0 1.59066E-06 None None None None N None 0 0 None 0 2.77316E-05 None 0 0 0 0 0
C/W 2368 Ig-13 13 rs1485265360 0.9049 None 1.0 N 0.72 0.453 0.598957545849 gnomAD-4.0.0 1.59065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85664E-06 0 0
I/T 2457 Ig-14 13 None 0.1212 None 0.117 N 0.417 0.16 0.688619951122 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 2545 Ig-15 13 rs761827668 0.1175 -0.717 0.201 N 0.317 0.172 0.166414681773 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/A 2545 Ig-15 13 rs761827668 0.1175 -0.717 0.201 N 0.317 0.172 0.166414681773 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 2545 Ig-15 13 rs761827668 0.1175 -0.717 0.201 N 0.317 0.172 0.166414681773 gnomAD-4.0.0 2.56155E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78357E-06 0 0
T/I 2545 Ig-15 13 rs1016165797 0.308 -0.161 0.379 N 0.359 0.405 0.405700215632 gnomAD-2.1.1 1.06E-05 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 1.55E-05 0
T/I 2545 Ig-15 13 rs1016165797 0.308 -0.161 0.379 N 0.359 0.405 0.405700215632 gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
T/I 2545 Ig-15 13 rs1016165797 0.308 -0.161 0.379 N 0.359 0.405 0.405700215632 gnomAD-4.0.0 1.67306E-05 None None None None N None 0 1.66756E-05 None 0 0 None 0 0 2.11869E-05 0 1.60056E-05
T/R 2545 Ig-15 13 None 0.2121 None 0.81 N 0.381 0.454 0.610832418033 gnomAD-4.0.0 1.36826E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79863E-06 0 0
T/S 2545 Ig-15 13 rs761827668 0.1475 -0.764 0.007 N 0.213 0.094 0.128392430309 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 2545 Ig-15 13 rs761827668 0.1475 -0.764 0.007 N 0.213 0.094 0.128392430309 gnomAD-4.0.0 1.59081E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
A/G 2632 Ig-16 12 rs1210961482 0.3781 -0.823 0.996 N 0.6 0.345 0.438278051908 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.63185E-04
A/G 2632 Ig-16 12 rs1210961482 0.3781 -0.823 0.996 N 0.6 0.345 0.438278051908 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85771E-06 0 0
A/T 2632 Ig-16 12 None 0.2732 None 0.992 N 0.642 0.308 0.385084120042 gnomAD-4.0.0 3.18202E-06 None None None None N None 0 0 None 0 0 None 0 2.41429E-04 0 1.43279E-05 0
T/A 2719 Ig-17 13 rs2091324218 0.1396 None 0.998 D 0.559 0.262 0.308904156042 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92382E-04 None 0 0 0 0 0
T/A 2719 Ig-17 13 rs2091324218 0.1396 None 0.998 D 0.559 0.262 0.308904156042 gnomAD-4.0.0 2.56179E-06 None None None None I None 0 0 None 0 2.42436E-05 None 0 0 2.39175E-06 0 0
T/S 2719 Ig-17 13 None 0.2621 None 0.999 D 0.581 0.266 0.27479166964 gnomAD-4.0.0 1.59114E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
P/L 2894 Ig-19 13 None 0.2546 None 0.999 N 0.734 0.461 0.754003673566 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 2981 Ig-20 13 None 0.4938 None 0.956 N 0.559 0.349 0.398133443147 gnomAD-4.0.0 6.84132E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99305E-07 0 0
L/P 3070 Ig-21 13 rs530883294 0.5136 -0.239 0.963 N 0.459 0.439 0.798563562665 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 5.46E-05 None 0 None 0 0 0
L/P 3070 Ig-21 13 rs530883294 0.5136 -0.239 0.963 N 0.459 0.439 0.798563562665 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92234E-04 None 0 0 0 0 0
L/P 3070 Ig-21 13 rs530883294 0.5136 -0.239 0.963 N 0.459 0.439 0.798563562665 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
L/P 3070 Ig-21 13 rs530883294 0.5136 -0.239 0.963 N 0.459 0.439 0.798563562665 gnomAD-4.0.0 3.84112E-06 None None None None I None 0 0 None 0 7.28049E-05 None 0 0 0 0 0
Q/L 3251 Ig-23 13 None 0.1255 None 0.351 N 0.446 0.288 0.488897681448 gnomAD-4.0.0 1.36833E-06 None None None None N None 0 0 None 0 5.03956E-05 None 0 0 0 0 0
Q/R 3251 Ig-23 13 None 0.1233 None 0.183 N 0.339 0.244 0.163833314356 gnomAD-4.0.0 6.84167E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99331E-07 0 0
S/F 3357 Ig-24 13 rs886042377 0.233 None 0.996 N 0.457 0.283 0.481616744073 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30907E-04 0 0 0 None 0 0 0 0 0
S/F 3357 Ig-24 13 rs886042377 0.233 None 0.996 N 0.457 0.283 0.481616744073 gnomAD-4.0.0 3.09792E-06 None None None None N None 0 5.00033E-05 None 0 0 None 0 0 8.47471E-07 0 1.60036E-05
S/T 3357 Ig-24 13 None 0.0906 None 0.134 N 0.199 0.157 0.154104182512 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
H/P 3477 Ig-25 13 rs1158438965 0.1459 None None None None 0.105 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/P 3477 Ig-25 13 rs1158438965 0.1459 None None None None 0.105 None gnomAD-4.0.0 6.57142E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
H/R 3477 Ig-25 13 rs1158438965 0.1048 -0.235 None None None 0.094 None gnomAD-4.0.0 1.59167E-06 None None None None N None 0 0 None 0 0 None 0 2.41429E-04 0 0 0
K/Q 3672 Ig-26 13 rs781663025 0.1441 0.122 None None None 0.139 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/Q 3672 Ig-26 13 rs781663025 0.1441 0.122 None None None 0.139 None gnomAD-4.0.0 1.59132E-06 None None None None I None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
S/I 3832 Ig-27 13 None 0.1177 None 0.001 N 0.247 0.131 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 3950 Ig-28 13 rs1254502584 0.0809 -0.631 None N 0.322 0.12 None gnomAD-2.1.1 8.05E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
A/T 3950 Ig-28 13 rs1254502584 0.0809 -0.631 None N 0.322 0.12 None gnomAD-4.0.0 4.77319E-06 None None None None I None 0 4.57268E-05 None 0 0 None 0 0 0 0 3.02389E-05
A/V 3950 Ig-28 13 rs1206322976 0.1012 -0.272 None N 0.182 0.096 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
A/V 3950 Ig-28 13 rs1206322976 0.1012 -0.272 None N 0.182 0.096 None gnomAD-4.0.0 1.59108E-06 None None None None I None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
E/G 4618 Ig-29 13 rs774836172 0.1527 -0.657 0.722 D 0.625 0.378 0.357313475932 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/G 4618 Ig-29 13 rs774836172 0.1527 -0.657 0.722 D 0.625 0.378 0.357313475932 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/G 4618 Ig-29 13 rs774836172 0.1527 -0.657 0.722 D 0.625 0.378 0.357313475932 gnomAD-4.0.0 1.67309E-05 None None None None N None 0 0 None 0 0 None 0 0 2.11894E-05 0 3.20195E-05
A/P 4900 Ig-32 13 rs72648923 0.1472 -0.637 1.0 N 0.671 0.34 0.629195211289 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/P 4900 Ig-32 13 rs72648923 0.1472 -0.637 1.0 N 0.671 0.34 0.629195211289 gnomAD-4.0.0 1.36849E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79893E-06 0 0
A/T 4900 Ig-32 13 None 0.1039 -0.422 0.999 N 0.675 0.293 None gnomAD-2.1.1 3.78068E-03 None None None None I None 1.23998E-04 4.24761E-04 None 1.83752E-03 0 None 5.88466E-04 None 1.53298E-02 4.66851E-03 3.23579E-03
A/T 4900 Ig-32 13 None 0.1039 -0.422 0.999 N 0.675 0.293 None gnomAD-3.1.2 3.20669E-03 None None None None I None 9.65E-05 1.96464E-04 0 2.01729E-03 0 None 1.60226E-02 3.16456E-03 4.30667E-03 1.24121E-03 1.91205E-03
A/T 4900 Ig-32 13 None 0.1039 -0.422 0.999 N 0.675 0.293 None 1000 genomes 1.79712E-03 None None None None I None 0 1.4E-03 None None 0 7E-03 None None None 1E-03 None
A/T 4900 Ig-32 13 None 0.1039 -0.422 0.999 N 0.675 0.293 None gnomAD-4.0.0 2.54745E-03 None None None None I None 7.99446E-05 4.33333E-04 None 1.25E-03 0 None 1.55679E-02 4.9505E-04 2.41906E-03 6.8069E-04 2.03285E-03
A/V 4900 Ig-32 13 rs771948633 0.1257 -0.139 0.884 N 0.37 0.284 None gnomAD-2.1.1 8.93E-05 None None None None I None 0 0 None 0 1.23431E-03 None 0 None 0 0 1.40647E-04
A/V 4900 Ig-32 13 rs771948633 0.1257 -0.139 0.884 N 0.37 0.284 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
A/V 4900 Ig-32 13 rs771948633 0.1257 -0.139 0.884 N 0.37 0.284 None gnomAD-4.0.0 1.36339E-05 None None None None I None 0 0 None 0 4.01481E-04 None 0 0 0 2.19582E-05 3.20266E-05
L/V 4994 Ig-33 14 None 0.0941 None 0.037 N 0.311 0.073 0.395745362164 gnomAD-4.0.0 1.60867E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8889E-06 0 0
V/M 5087 Ig-34 13 rs751652571 0.344 -0.435 0.999 N 0.583 0.177 0.577502390439 gnomAD-2.1.1 1.5E-05 None None None None I None 4.21E-05 0 None 0 0 None 1.12124E-04 None 0 0 0
V/M 5087 Ig-34 13 rs751652571 0.344 -0.435 0.999 N 0.583 0.177 0.577502390439 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 5087 Ig-34 13 rs751652571 0.344 -0.435 0.999 N 0.583 0.177 0.577502390439 gnomAD-4.0.0 4.38724E-06 None None None None I None 1.34448E-05 0 None 0 0 None 0 0 0 6.84041E-05 0
L/V 5180 Ig-35 13 None 0.0704 None 0.046 N 0.225 0.084 0.318540980066 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 5369 Ig-37 13 rs1407785236 0.1293 -1.456 None N 0.204 0.163 0.457197642564 gnomAD-2.1.1 8.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
V/A 5369 Ig-37 13 rs1407785236 0.1293 -1.456 None N 0.204 0.163 0.457197642564 gnomAD-4.0.0 3.4302E-06 None None None None N None 0 0 None 0 0 None 0 0 4.50702E-06 0 0
V/F 5369 Ig-37 13 None 0.1268 None 0.317 N 0.453 0.166 0.536521311054 gnomAD-4.0.0 6.86035E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16596E-05 0
V/I 5369 Ig-37 13 rs780410052 0.0715 -0.616 None N 0.221 0.113 0.222439326576 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
V/I 5369 Ig-37 13 rs780410052 0.0715 -0.616 None N 0.221 0.113 0.222439326576 gnomAD-4.0.0 3.43017E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70417E-06 1.16596E-05 1.66163E-05
L/P 5462 Ig-38 13 None 0.1478 None 0.995 N 0.638 0.477 0.864942860777 gnomAD-4.0.0 1.37563E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.35211E-05 0
L/Q 5462 Ig-38 13 rs778031659 0.1329 -0.257 0.995 N 0.613 0.269 0.833684530568 gnomAD-2.1.1 4.16E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.12E-06 0
L/Q 5462 Ig-38 13 rs778031659 0.1329 -0.257 0.995 N 0.613 0.269 0.833684530568 gnomAD-4.0.0 6.87817E-07 None None None None I None 0 0 None 0 0 None 0 0 9.02433E-07 0 0
L/F 5742 Ig-41 13 rs72648943 0.1543 -0.358 0.997 N 0.531 0.302 None gnomAD-2.1.1 3.08724E-04 None None None None I None 8.28E-05 5.69E-05 None 0 0 None 0 None 3.22009E-04 5.65869E-04 2.83046E-04
L/F 5742 Ig-41 13 rs72648943 0.1543 -0.358 0.997 N 0.531 0.302 None gnomAD-3.1.2 3.484E-04 None None None None I None 4.83E-05 0 0 0 0 None 4.70721E-04 0 6.6157E-04 0 4.78927E-04
L/F 5742 Ig-41 13 rs72648943 0.1543 -0.358 0.997 N 0.531 0.302 None gnomAD-4.0.0 5.06665E-04 None None None None I None 8.0156E-05 3.34012E-05 None 0 0 None 3.59768E-04 0 6.45358E-04 0 4.00641E-04
L/P 5742 Ig-41 13 rs750058681 0.3712 -0.167 0.997 N 0.69 0.502 0.831918458575 gnomAD-2.1.1 7.18E-06 None None None None I None 8.28E-05 0 None 0 0 None 0 None 0 0 0
L/P 5742 Ig-41 13 rs750058681 0.3712 -0.167 0.997 N 0.69 0.502 0.831918458575 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
L/P 5742 Ig-41 13 rs750058681 0.3712 -0.167 0.997 N 0.69 0.502 0.831918458575 gnomAD-4.0.0 3.72076E-06 None None None None I None 8.01603E-05 0 None 0 0 None 0 0 0 0 0
I/L 5931 Ig-43 13 None 0.1225 None 0.58 N 0.409 0.108 0.368183359018 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 5931 Ig-43 13 rs556014670 0.0712 -1.125 0.02 N 0.323 0.113 0.424670345773 gnomAD-2.1.1 4.07E-06 None None None None N None 6.51E-05 0 None 0 0 None 0 None 0 0 0
I/V 5931 Ig-43 13 rs556014670 0.0712 -1.125 0.02 N 0.323 0.113 0.424670345773 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 5931 Ig-43 13 rs556014670 0.0712 -1.125 0.02 N 0.323 0.113 0.424670345773 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
I/V 5931 Ig-43 13 rs556014670 0.0712 -1.125 0.02 N 0.323 0.113 0.424670345773 gnomAD-4.0.0 6.56513E-06 None None None None N None 2.40442E-05 0 None 0 0 None 0 0 0 0 0
N/D 6024 Ig-44 13 None 0.1131 None 0.301 N 0.305 0.139 0.163833314356 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 6024 Ig-44 13 rs759852969 0.069 0.174 0.042 N 0.257 0.087 0.126345400529 gnomAD-2.1.1 5.35E-05 None None None None N None 0 0 None 0 0 None 2.34474E-04 None 0 5.49E-05 0
N/S 6024 Ig-44 13 rs759852969 0.069 0.174 0.042 N 0.257 0.087 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
N/S 6024 Ig-44 13 rs759852969 0.069 0.174 0.042 N 0.257 0.087 0.126345400529 gnomAD-4.0.0 3.66371E-05 None None None None N None 0 0 None 0 0 None 0 0 3.31064E-05 2.09973E-04 1.60426E-05
R/K 6118 Ig-45 14 rs2154307652 0.1067 None 0.003 N 0.352 0.1 0.279370189704 gnomAD-4.0.0 1.59235E-06 None None None None I None 0 0 None 0 2.78087E-05 None 0 0 0 0 0
R/S 6118 Ig-45 14 None 0.4758 None 0.565 N 0.577 0.196 0.225215365344 gnomAD-4.0.0 3.18468E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86632E-05 0
V/A 6211 Ig-46 13 rs773463426 0.227 -0.57 0.999 N 0.598 0.315 0.698733648705 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/A 6211 Ig-46 13 rs773463426 0.227 -0.57 0.999 N 0.598 0.315 0.698733648705 gnomAD-4.0.0 1.59202E-06 None None None None N None 0 2.28749E-05 None 0 0 None 0 0 0 0 0
V/I 6211 Ig-46 13 rs1236160546 0.0897 -0.165 0.997 N 0.512 0.268 0.714023348238 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
V/I 6211 Ig-46 13 rs1236160546 0.0897 -0.165 0.997 N 0.512 0.268 0.714023348238 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
V/I 6211 Ig-46 13 rs1236160546 0.0897 -0.165 0.997 N 0.512 0.268 0.714023348238 gnomAD-4.0.0 1.31447E-05 None None None None N None 4.82462E-05 0 None 0 0 None 0 0 0 0 0
V/I 6304 Ig-47 13 None 0.0734 None 0.117 N 0.309 0.08 0.427368086475 gnomAD-4.0.0 6.88716E-07 None None None None I None 0 0 None 0 0 None 0 0 9.02961E-07 0 0
T/M 6397 Ig-48 13 rs199564845 0.1471 0.039 1.0 D 0.633 0.422 None gnomAD-2.1.1 2.82E-05 None None None None N None 1.29349E-04 8.74E-05 None 0 0 None 0 None 0 1.78E-05 0
T/M 6397 Ig-48 13 rs199564845 0.1471 0.039 1.0 D 0.633 0.422 None gnomAD-3.1.2 5.92E-05 None None None None N None 4.83E-05 1.96489E-04 0 0 0 None 0 0 5.88E-05 0 0
T/M 6397 Ig-48 13 rs199564845 0.1471 0.039 1.0 D 0.633 0.422 None gnomAD-4.0.0 2.79825E-05 None None None None N None 9.35404E-05 8.35478E-05 None 0 0 None 1.56392E-05 0 2.63781E-05 0 1.60679E-05
I/T 6586 Ig-50 13 rs896710187 0.244 None 0.324 N 0.359 0.136 0.642625386947 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 6586 Ig-50 13 rs896710187 0.244 None 0.324 N 0.359 0.136 0.642625386947 gnomAD-4.0.0 6.21717E-06 None None None None N None 1.33837E-05 0 None 0 0 None 0 0 7.64588E-06 0 0
I/V 6586 Ig-50 13 None 0.076 None None N 0.173 0.085 0.42573502686 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 6773 Ig-52 13 rs189557659 0.1339 -0.62 0.925 N 0.457 0.299 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 5.80271E-04 None 0 0 0 0 0
L/F 6773 Ig-52 13 rs189557659 0.1339 -0.62 0.925 N 0.457 0.299 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
L/F 6773 Ig-52 13 rs189557659 0.1339 -0.62 0.925 N 0.457 0.299 None gnomAD-4.0.0 3.28221E-05 None None None None I None 0 0 None 0 1.16449E-03 None 0 0 0 0 1.63372E-05
L/P 6773 Ig-52 13 rs1327286420 0.2704 -0.657 0.99 D 0.641 0.557 0.789426192391 gnomAD-4.0.0 1.64061E-06 None None None None I None 0 0 None 0 2.82917E-05 None 0 0 0 0 0
V/I 6866 Ig-53 13 None 0.0722 None 0.005 N 0.235 0.162 0.387042434762 gnomAD-4.0.0 1.60772E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88416E-06 0 0
V/L 7056 Ig-55 13 rs1306079131 0.1052 None 0.031 N 0.237 0.107 0.381916209588 gnomAD-4.0.0 6.84436E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99658E-07 0 0
V/M 7056 Ig-55 13 rs1306079131 0.0994 None 0.782 D 0.343 0.134 0.493089126863 gnomAD-4.0.0 1.36887E-06 None None None None I None 0 0 None 0 2.52232E-05 None 0 0 8.99658E-07 0 0
A/T 7335 Ig-58 13 rs1208605882 0.0653 -0.982 None N 0.187 0.124 0.0666544352282 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
A/T 7335 Ig-58 13 rs1208605882 0.0653 -0.982 None N 0.187 0.124 0.0666544352282 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/T 7335 Ig-58 13 rs1208605882 0.0653 -0.982 None N 0.187 0.124 0.0666544352282 gnomAD-4.0.0 4.0601E-06 None None None None N None 0 6.15688E-05 None 0 0 None 0 0 3.615E-06 0 0
I/N 7997 Ig-65 13 rs776368998 0.0927 None 0.171 N 0.487 0.16 0.483448007585 gnomAD-4.0.0 1.91592E-05 None None None None I None 0 0 None 0 0 None 0 0 2.51875E-05 0 0
I/V 7997 Ig-65 13 rs758227131 0.0592 0.023 None N 0.176 0.171 0.149567049428 gnomAD-2.1.1 1.78E-05 None None None None I None 0 5.66E-05 None 0 0 None 0 None 0 2.34E-05 0
I/V 7997 Ig-65 13 rs758227131 0.0592 0.023 None N 0.176 0.171 0.149567049428 gnomAD-3.1.2 1.32E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
I/V 7997 Ig-65 13 rs758227131 0.0592 0.023 None N 0.176 0.171 0.149567049428 gnomAD-4.0.0 8.05708E-06 None None None None I None 0 8.33583E-05 None 0 0 None 0 0 6.78174E-06 0 0
L/F 8090 Ig-66 13 None 0.1605 None 0.989 N 0.447 0.296 0.568036332872 gnomAD-4.0.0 6.85156E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00213E-07 0 0
E/D 8183 Ig-67 13 None 0.2824 None 0.979 N 0.327 0.33 0.250039746154 gnomAD-4.0.0 2.05312E-06 None None None None I None 5.978E-05 0 None 0 0 None 0 0 8.99633E-07 0 0
E/Q 8183 Ig-67 13 rs201365398 0.1497 0.44 0.959 N 0.376 0.261 None gnomAD-2.1.1 9.66E-05 None None None None I None 0 0 None 0 0 None 0 None 6.81417E-04 5.48E-05 4.23131E-04
E/Q 8183 Ig-67 13 rs201365398 0.1497 0.44 0.959 N 0.376 0.261 None gnomAD-3.1.2 3.29E-05 None None None None I None 0 0 0 0 0 None 4.71431E-04 0 0 0 0
E/Q 8183 Ig-67 13 rs201365398 0.1497 0.44 0.959 N 0.376 0.261 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
E/Q 8183 Ig-67 13 rs201365398 0.1497 0.44 0.959 N 0.376 0.261 None gnomAD-4.0.0 5.45413E-05 None None None None I None 0 1.6665E-05 None 0 0 None 1.25051E-03 0 4.23882E-06 0 3.20205E-05
T/A 8372 Ig-69 13 rs762359298 0.1138 -0.896 None N 0.156 0.091 0.206339911435 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 0 None 4.66E-05 0 0
T/A 8372 Ig-69 13 rs762359298 0.1138 -0.896 None N 0.156 0.091 0.206339911435 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
T/S 8372 Ig-69 13 rs762359298 0.1533 -0.681 None N 0.176 0.074 0.159798565429 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.04E-06 0
A/V 8468 Ig-70 13 rs762161074 0.0976 -0.113 0.026 N 0.223 0.162 0.321672782286 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/V 8468 Ig-70 13 rs762161074 0.0976 -0.113 0.026 N 0.223 0.162 0.321672782286 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86028E-06 0 0
L/P 8655 Ig-72 13 rs759578526 0.2914 -0.495 1.0 D 0.723 0.568 0.858636765436 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
L/P 8655 Ig-72 13 rs759578526 0.2914 -0.495 1.0 D 0.723 0.568 0.858636765436 gnomAD-4.0.0 1.36866E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79914E-06 0 0
L/R 8655 Ig-72 13 None 0.1808 None 1.0 N 0.717 0.43 0.832531937271 gnomAD-4.0.0 6.84328E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99569E-07 0 0
V/A 8748 Ig-73 13 rs1362528703 0.0931 -1.127 0.004 N 0.581 0.154 0.446913017954 gnomAD-2.1.1 7.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 7.83E-06 1.41283E-04
V/A 8748 Ig-73 13 rs1362528703 0.0931 -1.127 0.004 N 0.581 0.154 0.446913017954 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 8748 Ig-73 13 rs1362528703 0.0931 -1.127 0.004 N 0.581 0.154 0.446913017954 gnomAD-4.0.0 3.10035E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39165E-06 0 1.6022E-05
V/I 8748 Ig-73 13 rs1456259621 0.063 -0.303 None N 0.254 0.102 0.295623431141 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/I 8748 Ig-73 13 rs1456259621 0.063 -0.303 None N 0.254 0.102 0.295623431141 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 8748 Ig-73 13 rs1456259621 0.063 -0.303 None N 0.254 0.102 0.295623431141 gnomAD-4.0.0 2.56537E-06 None None None None N None 1.69268E-05 0 None 0 0 None 0 0 2.39538E-06 0 0
V/L 8748 Ig-73 13 None 0.0906 None None N 0.271 0.109 0.192905019026 gnomAD-4.0.0 1.5936E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86159E-06 0 0
E/D 9124 Ig-77 13 None 0.2965 None 0.026 N 0.284 0.046 0.158396225186 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 9409 Ig-80 13 None 0.1084 None None None 0.149 0.144 0.422283790207 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 9409 Ig-80 13 rs1239606732 0.1113 -0.413 0.093 None 0.335 0.085 0.366085729538 gnomAD-2.1.1 7.15E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
V/M 9409 Ig-80 13 rs1239606732 0.1113 -0.413 0.093 None 0.335 0.085 0.366085729538 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
V/M 9409 Ig-80 13 rs1239606732 0.1113 -0.413 0.093 None 0.335 0.085 0.366085729538 gnomAD-4.0.0 8.05552E-06 None None None None I None 9.34205E-05 0 None 0 0 None 0 1.64474E-04 8.47578E-07 0 6.40369E-05
S/R 9602 Ig-82 13 rs768790360 0.2844 -0.178 0.033 None 0.461 0.219 0.0762999501168 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/R 9602 Ig-82 13 rs768790360 0.2844 -0.178 0.033 None 0.461 0.219 0.0762999501168 gnomAD-4.0.0 3.18313E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86722E-05 0
V/E 9710 Ig-83 13 rs1196573815 0.4289 None 0.175 None 0.526 0.28 0.673560067753 gnomAD-3.1.2 1.31E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 0 0 0
V/E 9710 Ig-83 13 rs1196573815 0.4289 None 0.175 None 0.526 0.28 0.673560067753 gnomAD-4.0.0 1.31385E-05 None None None None I None 4.82369E-05 0 None 0 0 None 0 0 0 0 0
V/I 9710 Ig-83 13 rs72649002 0.0782 -0.278 0.004 None 0.189 0.084 None gnomAD-2.1.1 1.51403E-03 None None None None I None 5.42979E-04 2.00481E-04 None 0 1.94468E-02 None 6.67E-05 None 0 1.11201E-04 1.13443E-03
V/I 9710 Ig-83 13 rs72649002 0.0782 -0.278 0.004 None 0.189 0.084 None gnomAD-3.1.2 1.01852E-03 None None None None I None 5.54859E-04 1.50583E-03 0 0 1.90458E-02 None 0 0 2.94E-05 4.14422E-04 2.86533E-03
V/I 9710 Ig-83 13 rs72649002 0.0782 -0.278 0.004 None 0.189 0.084 None 1000 genomes 4.59265E-03 None None None None I None 0 1.4E-03 None None 2.18E-02 0 None None None 0 None
V/I 9710 Ig-83 13 rs72649002 0.0782 -0.278 0.004 None 0.189 0.084 None gnomAD-4.0.0 5.45984E-04 None None None None I None 4.66617E-04 5.35475E-04 None 0 1.24649E-02 None 0 1.65071E-04 5.17499E-05 1.76526E-04 2.82033E-03
V/L 9710 Ig-83 13 None 0.2139 None 0.001 None 0.174 0.076 0.307016933798 gnomAD-4.0.0 6.85181E-07 None None None None I None 0 0 None 0 0 None 0 0 9.0031E-07 0 0
L/W 9912 Ig-84 13 None 0.5354 None 0.997 None 0.476 0.311 0.754980121303 gnomAD-4.0.0 1.59922E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8603E-06 0 0
K/N 10001 Ig-85 13 rs747230082 0.9102 0.108 0.949 None 0.512 0.269 0.232513804876 gnomAD-2.1.1 8.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.85E-06 0
K/N 10001 Ig-85 13 rs747230082 0.9102 0.108 0.949 None 0.512 0.269 0.232513804876 gnomAD-4.0.0 3.18227E-06 None None None None N None 0 2.28624E-05 None 0 0 None 0 0 2.8582E-06 0 0
K/R 10001 Ig-85 13 None 0.1304 None 0.84 None 0.515 0.226 0.300449992093 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
S/N 10090 Ig-86 13 rs2075204317 0.4789 None 0.061 None 0.143 0.146 0.218845423259 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 10090 Ig-86 13 rs2075204317 0.4789 None 0.061 None 0.143 0.146 0.218845423259 gnomAD-4.0.0 7.68494E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19625E-05 0 2.84349E-05
T/R 13695 Ig-87 12 None 0.2132 None 0.062 N 0.485 0.071 0.225215365344 gnomAD-4.0.0 1.59221E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85982E-06 0 0
V/A 13793 Ig-88 14 None 0.6307 None 0.425 N 0.299 0.231 0.319686207203 gnomAD-4.0.0 1.37447E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80516E-06 0 0
K/T 13886 Ig-89 11 None 0.6971 None 0.999 N 0.793 0.341 0.252162846088 gnomAD-4.0.0 6.89835E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04439E-07 0 0
Y/F 13977 Ig-90 13 None 0.1527 None 0.016 N 0.338 0.095 0.200317383148 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/L 14066 Ig-91 13 None 0.3077 None 0.999 N 0.701 0.441 0.49741755877 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02608E-05
K/E 14154 Ig-92 13 rs752701347 0.4269 0.118 0.996 N 0.631 0.287 0.461759001683 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/E 14154 Ig-92 13 rs752701347 0.4269 0.118 0.996 N 0.631 0.287 0.461759001683 gnomAD-4.0.0 1.59257E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
V/E 14243 Ig-93 13 None 0.3348 None 0.782 N 0.538 0.208 0.550005317886 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/L 14420 Ig-95 13 None 0.9213 None 0.003 N 0.238 0.339 0.12205267543 gnomAD-4.0.0 1.36896E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79929E-06 0 0
K/Q 14509 Ig-96 13 rs2059909024 0.2799 None 1.0 D 0.711 0.452 0.423836183345 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/Q 14509 Ig-96 13 rs2059909024 0.2799 None 1.0 D 0.711 0.452 0.423836183345 gnomAD-4.0.0 2.49553E-06 None None None None N None 0 0 None 0 0 None 0 0 3.40532E-06 0 0
K/R 14509 Ig-96 13 rs772970275 0.109 -0.163 0.999 N 0.645 0.33 0.477298106951 gnomAD-2.1.1 2.15E-05 None None None None N None 0 1.536E-04 None 0 0 None 0 None 0 0 0
K/R 14509 Ig-96 13 rs772970275 0.109 -0.163 0.999 N 0.645 0.33 0.477298106951 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
K/R 14509 Ig-96 13 rs772970275 0.109 -0.163 0.999 N 0.645 0.33 0.477298106951 gnomAD-4.0.0 7.79452E-06 None None None None N None 0 1.04091E-04 None 0 0 None 0 0 0 0 0
M/I 14687 Ig-98 13 rs775432065 0.1741 -0.101 None N 0.037 0.057 0.0482279557977 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
M/I 14687 Ig-98 13 rs775432065 0.1741 -0.101 None N 0.037 0.057 0.0482279557977 gnomAD-4.0.0 3.18504E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72059E-06 0 0
M/K 14687 Ig-98 13 rs2059719184 0.2584 None 0.007 N 0.304 0.105 0.332386209738 gnomAD-4.0.0 6.84431E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99654E-07 0 0
M/L 14687 Ig-98 13 None 0.1234 None None N 0.107 0.097 0.327952845175 gnomAD-4.0.0 1.59256E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86023E-06 0 0
M/T 14687 Ig-98 13 rs2059719184 0.1384 None None N 0.095 0.07 0.440810947182 gnomAD-4.0.0 3.42215E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59862E-06 0 1.65744E-05
T/I 14776 Ig-99 12 rs1250844275 0.2749 -0.048 1.0 N 0.687 0.489 0.650954787814 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 14776 Ig-99 12 rs1250844275 0.2749 -0.048 1.0 N 0.687 0.489 0.650954787814 gnomAD-4.0.0 1.3691E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79962E-06 0 0
E/K 14865 Ig-100 13 rs543102139 0.3182 0.7 0.992 N 0.63 0.372 0.322510055762 gnomAD-2.1.1 1.18235E-04 None None None None N None 0 2.27118E-04 None 0 9.32063E-04 None 0 None 0 5.49E-05 0
E/K 14865 Ig-100 13 rs543102139 0.3182 0.7 0.992 N 0.63 0.372 0.322510055762 gnomAD-3.1.2 1.71138E-04 None None None None N None 0 9.85028E-04 0 0 1.16686E-03 None 0 0 7.36E-05 0 0
E/K 14865 Ig-100 13 rs543102139 0.3182 0.7 0.992 N 0.63 0.372 0.322510055762 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
E/K 14865 Ig-100 13 rs543102139 0.3182 0.7 0.992 N 0.63 0.372 0.322510055762 gnomAD-4.0.0 5.70574E-05 None None None None N None 2.66973E-05 3.67328E-04 None 0 5.82072E-04 None 0 0 3.56227E-05 0 0
R/K 14954 Ig-101 13 rs2058479369 0.0558 None None N 0.189 0.136 0.1749357433 gnomAD-4.0.0 6.87264E-07 None None None None I None 0 0 None 0 0 None 0 0 9.01921E-07 0 0
R/T 14954 Ig-101 13 None 0.1831 None 0.014 N 0.357 0.154 0.198526703765 gnomAD-4.0.0 6.87264E-07 None None None None I None 0 0 None 0 0 None 0 0 9.01921E-07 0 0
S/N 15043 Ig-102 13 rs376144178 0.1032 -0.846 None N 0.17 0.077 None gnomAD-2.1.1 4.33E-05 None None None None N None 0 0 None 0 0 None 0 None 0 9.52E-05 0
S/N 15043 Ig-102 13 rs376144178 0.1032 -0.846 None N 0.17 0.077 None gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 0 0 8.84E-05 0 0
S/N 15043 Ig-102 13 rs376144178 0.1032 -0.846 None N 0.17 0.077 None gnomAD-4.0.0 7.38245E-05 None None None None N None 0 0 None 0 0 None 0 0 9.24511E-05 0 1.60431E-04
M/L 15314 Ig-105 13 rs1391292606 0.1797 None None N 0.161 0.212 0.474643619859 gnomAD-4.0.0 6.85269E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00408E-07 0 0
M/V 15314 Ig-105 13 rs1391292606 0.0949 -0.259 0.047 N 0.255 0.183 0.441636318388 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
M/V 15314 Ig-105 13 rs1391292606 0.0949 -0.259 0.047 N 0.255 0.183 0.441636318388 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 15314 Ig-105 13 rs1391292606 0.0949 -0.259 0.047 N 0.255 0.183 0.441636318388 gnomAD-4.0.0 3.10318E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54553E-06 0 3.20935E-05
T/S 15403 Ig-106 13 None 0.2162 None 0.969 N 0.542 0.259 0.464098490096 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/D 15492 Ig-107 13 None 0.4061 None 0.994 N 0.593 0.413 0.747887111329 gnomAD-4.0.0 1.59536E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86472E-06 0 0
A/T 15492 Ig-107 13 rs1370664332 0.127 -0.714 0.98 N 0.49 0.262 0.350307294319 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
A/T 15492 Ig-107 13 rs1370664332 0.127 -0.714 0.98 N 0.49 0.262 0.350307294319 gnomAD-4.0.0 3.19057E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72951E-06 0 0
I/T 15975 Ig-109 8 rs755834931 0.2673 -1.71 0.324 N 0.345 0.178 0.515938915144 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
I/T 15975 Ig-109 8 rs755834931 0.2673 -1.71 0.324 N 0.345 0.178 0.515938915144 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 15975 Ig-109 8 rs755834931 0.2673 -1.71 0.324 N 0.345 0.178 0.515938915144 gnomAD-4.0.0 2.48048E-06 None None None None N None 0 3.33767E-05 None 0 0 None 0 0 1.6962E-06 0 0
K/E 16271 Ig-110 10 rs2056978022 0.8392 None 0.996 N 0.613 0.426 0.411265580357 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 16271 Ig-110 10 rs2056978022 0.8392 None 0.996 N 0.613 0.426 0.411265580357 gnomAD-4.0.0 6.58129E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47241E-05 0 0
I/T 16967 Ig-111 13 rs763447020 0.1191 -0.557 0.801 N 0.399 0.284 0.651126778619 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
I/T 16967 Ig-111 13 rs763447020 0.1191 -0.557 0.801 N 0.399 0.284 0.651126778619 gnomAD-4.0.0 4.10821E-06 None None None None I None 2.99222E-05 0 None 0 0 None 0 0 2.69955E-06 1.15993E-05 1.65881E-05
M/I 17685 Ig-113 9 rs200387466 0.3726 0.171 0.017 N 0.209 0.177 0.493156425868 gnomAD-2.1.1 2.04339E-04 None None None None I None 2.27668E-03 2.83E-05 None 0 0 None 0 None 0 0 1.40726E-04
M/I 17685 Ig-113 9 rs200387466 0.3726 0.171 0.017 N 0.209 0.177 0.493156425868 gnomAD-3.1.2 6.71088E-04 None None None None I None 2.38992E-03 1.96747E-04 0 0 0 None 0 0 0 0 0
M/I 17685 Ig-113 9 rs200387466 0.3726 0.171 0.017 N 0.209 0.177 0.493156425868 1000 genomes 7.98722E-04 None None None None I None 3E-03 0 None None 0 0 None None None 0 None
M/I 17685 Ig-113 9 rs200387466 0.3726 0.171 0.017 N 0.209 0.177 0.493156425868 gnomAD-4.0.0 1.27707E-04 None None None None I None 2.49413E-03 8.33667E-05 None 0 0 None 0 0 3.3916E-06 0 1.60159E-04
M/K 17685 Ig-113 9 None 0.1764 None 0.101 N 0.405 0.236 0.552205712323 gnomAD-4.0.0 3.18548E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72181E-06 0 0
M/T 17685 Ig-113 9 rs1289030052 0.2375 None 0.003 N 0.231 0.189 0.723229803861 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/T 17685 Ig-113 9 rs1289030052 0.2375 None 0.003 N 0.231 0.189 0.723229803861 gnomAD-4.0.0 6.41157E-06 None None None None I None 0 0 None 0 0 None 0 0 1.19764E-05 0 0
M/V 17685 Ig-113 9 rs2055217957 0.1007 None 0.001 N 0.183 0.085 0.39619538035 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/V 17685 Ig-113 9 rs2055217957 0.1007 None 0.001 N 0.183 0.085 0.39619538035 gnomAD-4.0.0 6.81979E-06 None None None None I None 0 0 None 0 0 None 0 1.64636E-04 8.47902E-06 0 0
K/R 17979 Ig-114 12 None 0.0824 None 0.001 N 0.289 0.054 0.267299060538 gnomAD-4.0.0 1.60204E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44383E-05 0
E/D 18697 Ig-116 10 rs767433299 0.283 -0.15 0.996 N 0.541 0.219 0.288727942641 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.11E-06 0
E/D 18697 Ig-116 10 rs767433299 0.283 -0.15 0.996 N 0.541 0.219 0.288727942641 gnomAD-4.0.0 1.61808E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89149E-06 0 0
H/L 19105 Ig-117 11 rs1450682516 0.3453 None 1.0 N 0.722 0.468 0.610363733556 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/L 19105 Ig-117 11 rs1450682516 0.3453 None 1.0 N 0.722 0.468 0.610363733556 gnomAD-4.0.0 5.57924E-06 None None None None I None 0 0 None 0 0 None 0 0 6.78225E-06 0 1.6019E-05
H/R 19105 Ig-117 11 None 0.1613 None 1.0 N 0.684 0.496 0.521601224155 gnomAD-4.0.0 1.36889E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79928E-06 0 0
H/Y 19105 Ig-117 11 rs2052113416 0.2341 None 0.999 N 0.607 0.442 0.519568866481 gnomAD-4.0.0 3.18518E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86002E-06 1.4332E-05 0
R/P 19399 Ig-118 9 None 0.6725 None 1.0 D 0.596 0.35 0.534046140783 gnomAD-4.0.0 2.05321E-06 None None None None I None 0 0 None 0 0 None 0 1.73732E-04 1.79916E-06 0 0
R/Q 19399 Ig-118 9 rs759893392 0.1963 0.021 0.999 N 0.531 0.296 0.370240404367 gnomAD-2.1.1 4.03E-05 None None None None I None 0 0 None 0 1.12575E-04 None 3.27E-05 None 0 6.24E-05 0
R/Q 19399 Ig-118 9 rs759893392 0.1963 0.021 0.999 N 0.531 0.296 0.370240404367 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 19399 Ig-118 9 rs759893392 0.1963 0.021 0.999 N 0.531 0.296 0.370240404367 gnomAD-4.0.0 3.84336E-05 None None None None I None 0 0 None 0 4.47648E-05 None 1.56279E-05 0 4.66253E-05 1.09815E-05 4.80507E-05
K/N 19799 Ig-119 10 rs570087924 0.7337 0.066 0.117 N 0.37 0.126 0.192905019026 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
K/N 19799 Ig-119 10 rs570087924 0.7337 0.066 0.117 N 0.37 0.126 0.192905019026 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93798E-04 None 0 0 0 0 0
K/N 19799 Ig-119 10 rs570087924 0.7337 0.066 0.117 N 0.37 0.126 0.192905019026 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
K/N 19799 Ig-119 10 rs570087924 0.7337 0.066 0.117 N 0.37 0.126 0.192905019026 gnomAD-4.0.0 6.56935E-06 None None None None N None 0 0 None 0 1.9425E-04 None 0 0 0 0 0
K/R 19799 Ig-119 10 None 0.0778 None None N 0.233 0.111 0.119812018005 gnomAD-4.0.0 1.59208E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85945E-06 0 0
K/N 20091 Ig-120 12 rs775961664 0.886 0.123 1.0 D 0.722 0.384 0.31077124679 gnomAD-2.1.1 4.29E-06 None None None None N None 0 0 None 0 0 None 3.78E-05 None 0 0 0
K/N 20091 Ig-120 12 rs775961664 0.886 0.123 1.0 D 0.722 0.384 0.31077124679 gnomAD-4.0.0 1.38387E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.41371E-05 0
R/K 20489 Ig-121 11 rs562641765 0.2567 0.008 0.997 N 0.553 0.4 None gnomAD-2.1.1 1.82E-05 None None None None I None 0 0 None 0 2.30203E-04 None 0 None 0 0 0
R/K 20489 Ig-121 11 rs562641765 0.2567 0.008 0.997 N 0.553 0.4 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 3.87898E-04 None 0 0 2.94E-05 0 0
R/K 20489 Ig-121 11 rs562641765 0.2567 0.008 0.997 N 0.553 0.4 None 1000 genomes 3.99361E-04 None None None None I None 0 0 None None 2E-03 0 None None None 0 None
R/K 20489 Ig-121 11 rs562641765 0.2567 0.008 0.997 N 0.553 0.4 None gnomAD-4.0.0 6.32606E-06 None None None None I None 0 0 None 0 1.57176E-04 None 0 0 2.57752E-06 0 0
K/E 20782 Ig-122 14 None 0.6167 None 0.477 N 0.583 0.302 0.340032825777 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/T 20782 Ig-122 14 rs750969532 0.5213 0.003 0.864 N 0.558 0.426 0.391000631824 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/T 20782 Ig-122 14 rs750969532 0.5213 0.003 0.864 N 0.558 0.426 0.391000631824 gnomAD-4.0.0 1.59199E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
R/G 21187 Ig-123 11 rs368288863 0.9228 -0.173 0.892 N 0.575 0.467 None gnomAD-2.1.1 4.05E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
R/G 21187 Ig-123 11 rs368288863 0.9228 -0.173 0.892 N 0.575 0.467 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/G 21187 Ig-123 11 rs368288863 0.9228 -0.173 0.892 N 0.575 0.467 None gnomAD-4.0.0 2.48153E-06 None None None None I None 0 0 None 0 0 None 0 0 3.39306E-06 0 0
R/K 21187 Ig-123 11 None 0.289 None 0.63 N 0.537 0.213 0.326616659874 gnomAD-4.0.0 2.73989E-06 None None None None I None 0 0 None 0 0 None 0 0 3.60065E-06 0 0
R/C 22274 Ig-126 10 rs770627108 0.6456 -0.547 1.0 N 0.771 0.572 0.637424115254 gnomAD-2.1.1 8.11E-06 None None None None I None 0 2.92E-05 None 0 0 None 0 None 0 8.97E-06 0
R/C 22274 Ig-126 10 rs770627108 0.6456 -0.547 1.0 N 0.771 0.572 0.637424115254 gnomAD-3.1.2 1.32E-05 None None None None I None 0 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
R/C 22274 Ig-126 10 rs770627108 0.6456 -0.547 1.0 N 0.771 0.572 0.637424115254 gnomAD-4.0.0 2.35703E-05 None None None None I None 0 3.34113E-05 None 0 2.24075E-05 None 0 0 2.79865E-05 1.10057E-05 1.60308E-05
R/H 22274 Ig-126 10 None 0.2949 -0.748 1.0 N 0.734 0.436 0.518092603711 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 1.79E-05 0
R/H 22274 Ig-126 10 None 0.2949 -0.748 1.0 N 0.734 0.436 0.518092603711 gnomAD-4.0.0 9.58641E-06 None None None None I None 2.99258E-05 2.23964E-05 None 0 7.59955E-05 None 0 0 7.19907E-06 1.16074E-05 0
R/L 22274 Ig-126 10 rs772979195 0.7664 0.342 1.0 N 0.686 0.434 0.590198699859 gnomAD-2.1.1 1.62E-05 None None None None I None 1.94376E-04 0 None 0 0 None 0 None 0 8.96E-06 0
R/L 22274 Ig-126 10 rs772979195 0.7664 0.342 1.0 N 0.686 0.434 0.590198699859 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/L 22274 Ig-126 10 rs772979195 0.7664 0.342 1.0 N 0.686 0.434 0.590198699859 gnomAD-4.0.0 2.48069E-06 None None None None I None 4.0078E-05 0 None 0 0 None 0 0 8.48011E-07 0 0
K/T 22959 Ig-128 10 None 0.5401 None 0.997 N 0.596 0.437 0.477298106951 gnomAD-4.0.0 1.62294E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.0722E-05
R/K 23357 Ig-129 13 rs375401995 0.2413 -0.084 0.006 N 0.335 0.147 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65837E-04
R/T 23357 Ig-129 13 rs375401995 0.9014 -0.133 0.822 D 0.581 0.408 0.496891249646 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 1.65837E-04
R/T 23357 Ig-129 13 rs375401995 0.9014 -0.133 0.822 D 0.581 0.408 0.496891249646 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/T 23357 Ig-129 13 rs375401995 0.9014 -0.133 0.822 D 0.581 0.408 0.496891249646 gnomAD-4.0.0 8.05747E-06 None None None None I None 0 0 None 0 0 None 0 0 1.01727E-05 0 1.60149E-05
R/K 24441 Ig-132 11 rs1559418326 0.3167 None 0.997 N 0.581 0.307 0.40722173914 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/K 24441 Ig-132 11 rs1559418326 0.3167 None 0.997 N 0.581 0.307 0.40722173914 gnomAD-4.0.0 3.42177E-06 None None None None I None 0 2.23664E-05 None 0 0 None 0 0 3.59846E-06 0 0
L/P 24728 Ig-133 13 rs1708337255 0.233 None 0.97 N 0.633 0.506 0.80197800866 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
H/P 25124 Ig-134 14 None 0.1449 None 0.106 N 0.525 0.285 0.380052290102 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
R/S 25523 Ig-135 10 None 0.9471 None 0.892 N 0.675 0.412 0.32082282376 gnomAD-4.0.0 6.84503E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99645E-07 0 0
Q/H 25810 Ig-136 13 None 0.2901 None 0.939 N 0.372 0.358 0.352910780287 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/P 25810 Ig-136 13 None 0.1233 None 0.979 N 0.425 0.481 0.397391247328 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85971E-06 0 0
N/S 26206 Ig-137 14 rs1400612460 0.0909 0.103 0.822 N 0.442 0.23 0.184867976434 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.67673E-04
N/S 26206 Ig-137 14 rs1400612460 0.0909 0.103 0.822 N 0.442 0.23 0.184867976434 gnomAD-4.0.0 1.59447E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02957E-05
R/K 26605 Ig-138 12 None 0.1911 None 0.014 N 0.343 0.088 0.329282125956 gnomAD-4.0.0 6.84266E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65684E-05
R/T 26605 Ig-138 12 rs1263615793 0.8014 -0.224 0.822 N 0.567 0.389 0.517104213562 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/T 26605 Ig-138 12 rs1263615793 0.8014 -0.224 0.822 N 0.567 0.389 0.517104213562 gnomAD-4.0.0 1.36853E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
H/R 27288 Ig-140 11 None 0.0737 None None N 0.15 0.129 0.183819452728 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
R/C 27688 Ig-141 13 rs757441189 0.6926 -0.191 1.0 D 0.696 0.567 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/C 27688 Ig-141 13 rs757441189 0.6926 -0.191 1.0 D 0.696 0.567 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 6.32911E-03 0 0 0
R/C 27688 Ig-141 13 rs757441189 0.6926 -0.191 1.0 D 0.696 0.567 None gnomAD-4.0.0 4.77432E-06 None None None None I None 5.65739E-05 0 None 0 0 None 0 0 0 1.43271E-05 3.02444E-05
R/H 27688 Ig-141 13 rs185002960 0.2997 -0.61 0.999 N 0.606 0.411 None gnomAD-2.1.1 3.72487E-03 None None None None I None 3.3066E-04 1.69635E-04 None 1.93311E-04 3.07535E-04 None 1.96091E-04 None 3.14775E-02 1.62335E-03 2.94613E-03
R/H 27688 Ig-141 13 rs185002960 0.2997 -0.61 0.999 N 0.606 0.411 None gnomAD-3.1.2 3.05147E-03 None None None None I None 3.13813E-04 6.57E-05 0 2.88184E-04 0 None 3.23463E-02 0 1.47016E-03 2.07297E-04 2.39234E-03
R/H 27688 Ig-141 13 rs185002960 0.2997 -0.61 0.999 N 0.606 0.411 None 1000 genomes 1.39776E-03 None None None None I None 0 0 None None 0 6E-03 None None None 1E-03 None
R/H 27688 Ig-141 13 rs185002960 0.2997 -0.61 0.999 N 0.606 0.411 None gnomAD-4.0.0 1.95397E-03 None None None None I None 3.3328E-04 1.83425E-04 None 2.02716E-04 3.79041E-04 None 2.99128E-02 0 9.01918E-04 9.88186E-05 1.71271E-03
R/L 27688 Ig-141 13 None 0.8285 None 0.975 N 0.59 0.423 0.708922172023 gnomAD-4.0.0 6.84244E-07 None None None None I None 2.98829E-05 0 None 0 0 None 0 0 0 0 0
R/P 27688 Ig-141 13 rs185002960 0.854 0.319 0.109 N 0.545 0.39 0.519514513453 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/P 27688 Ig-141 13 rs185002960 0.854 0.319 0.109 N 0.545 0.39 0.519514513453 gnomAD-3.1.2 2.63E-05 None None None None I None 9.66E-05 0 0 0 0 None 0 0 0 0 0
R/P 27688 Ig-141 13 rs185002960 0.854 0.319 0.109 N 0.545 0.39 0.519514513453 gnomAD-4.0.0 4.33802E-06 None None None None I None 7.99893E-05 0 None 0 0 None 0 0 0 0 1.60067E-05
K/N 27975 Ig-142 13 None 0.7612 None 0.942 N 0.529 0.328 0.293502639404 gnomAD-4.0.0 6.8473E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99777E-07 0 0
K/R 27975 Ig-142 13 None 0.0939 None 0.698 N 0.566 0.176 0.264081493735 gnomAD-4.0.0 1.5944E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86174E-06 0 0
K/R 28370 Ig-143 13 rs1316361788 0.0871 None 0.025 N 0.299 0.11 0.207176502487 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/E 28767 Ig-144 13 rs1348921301 0.4392 None 0.958 N 0.669 0.392 0.410071178582 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 28767 Ig-144 13 rs1348921301 0.4392 None 0.958 N 0.669 0.392 0.410071178582 gnomAD-4.0.0 6.57281E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
R/T 29057 Ig-145 13 rs753286150 0.6649 -0.197 0.22 N 0.549 0.293 0.427139414373 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
R/T 29057 Ig-145 13 rs753286150 0.6649 -0.197 0.22 N 0.549 0.293 0.427139414373 gnomAD-4.0.0 3.18573E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85858E-06 1.43819E-05 0
R/G 29453 Ig-146 10 rs773524612 0.3574 -0.176 0.324 N 0.508 0.515 0.531679877283 gnomAD-2.1.1 8.07E-06 None None None None I None 6.46E-05 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 29453 Ig-146 10 rs773524612 0.3574 -0.176 0.324 N 0.508 0.515 0.531679877283 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/G 29453 Ig-146 10 rs773524612 0.3574 -0.176 0.324 N 0.508 0.515 0.531679877283 gnomAD-4.0.0 7.68665E-06 None None None None I None 8.45566E-05 0 None 0 0 None 0 0 0 1.34063E-05 0
R/K 29453 Ig-146 10 None 0.0983 None None N 0.213 0.14 0.312306559268 gnomAD-4.0.0 1.36844E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.15974E-05 1.65678E-05
R/S 29453 Ig-146 10 None 0.552 None 0.193 N 0.458 0.305 0.310458034454 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 29852 Ig-147 11 rs771570602 0.087 -0.025 0.217 N 0.322 0.132 0.201204373187 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
K/R 29852 Ig-147 11 rs771570602 0.087 -0.025 0.217 N 0.322 0.132 0.201204373187 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 30539 Ig-149 8 rs1553536395 0.0809 -0.023 0.217 N 0.382 0.136 0.265010934533 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/R 30539 Ig-149 8 rs1553536395 0.0809 -0.023 0.217 N 0.382 0.136 0.265010934533 gnomAD-4.0.0 5.47454E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19661E-06 0 0
K/R 31228 Ig-151 11 rs368714667 0.0894 0.184 0.928 N 0.613 0.185 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/R 31228 Ig-151 11 rs368714667 0.0894 0.184 0.928 N 0.613 0.185 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
K/R 31228 Ig-151 11 rs368714667 0.0894 0.184 0.928 N 0.613 0.185 None gnomAD-4.0.0 3.40838E-05 None None None None I None 0 0 None 0 0 None 0 0 4.66174E-05 0 0
R/K 31628 Ig-152 8 rs1697174649 0.1901 None 0.906 N 0.435 0.164 0.276482976112 gnomAD-4.0.0 1.59161E-06 None None None None I None 0 0 None 0 2.77639E-05 None 0 0 0 0 0
R/G 32027 Ig-153 11 rs770295329 0.8815 -0.421 1.0 N 0.655 0.52 0.784331960839 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/G 32027 Ig-153 11 rs770295329 0.8815 -0.421 1.0 N 0.655 0.52 0.784331960839 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/G 32027 Ig-153 11 rs770295329 0.8815 -0.421 1.0 N 0.655 0.52 0.784331960839 gnomAD-4.0.0 2.02987E-06 None None None None I None 1.74721E-05 0 None 0 0 None 0 0 0 4.6966E-05 0
R/K 32027 Ig-153 11 None 0.2567 None 0.997 N 0.569 0.405 0.374434639691 gnomAD-4.0.0 6.84346E-07 None None None None I None 0 0 None 0 2.51965E-05 None 0 0 0 0 0
R/M 32027 Ig-153 11 rs748483895 0.8206 -0.292 1.0 N 0.683 0.551 0.679741279585 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
R/M 32027 Ig-153 11 rs748483895 0.8206 -0.292 1.0 N 0.683 0.551 0.679741279585 gnomAD-4.0.0 1.36869E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31938E-05 0
P/A 32319 Ig-154 13 rs1395301319 0.12 -0.505 0.338 N 0.481 0.267 0.233150807113 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/A 32319 Ig-154 13 rs1395301319 0.12 -0.505 0.338 N 0.481 0.267 0.233150807113 gnomAD-4.0.0 1.59289E-06 None None None None I None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
P/L 32319 Ig-154 13 None 0.1672 None 0.782 N 0.656 0.252 0.647102547044 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
K/E 33113 Ig-156 13 None 0.378 None 0.29 N 0.551 0.209 0.260735089382 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
A/D 33209 Ig-157 7 None 0.3648 None 0.928 N 0.471 0.267 0.701518117412 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 33209 Ig-157 7 rs1244887390 0.1934 -0.593 0.996 N 0.423 0.385 0.557405679382 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66113E-04
A/P 33209 Ig-157 7 rs1244887390 0.1934 -0.593 0.996 N 0.423 0.385 0.557405679382 gnomAD-4.0.0 3.18307E-06 None None None None N None 0 2.28697E-05 None 0 0 None 0 0 0 0 3.02407E-05
R/K 33508 Ig-158 13 rs758673294 0.1288 -0.489 None N 0.245 0.117 0.315903272564 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/S 33508 Ig-158 13 None 0.8728 None 0.113 N 0.433 0.24 0.141422826196 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
R/T 33508 Ig-158 13 rs758673294 0.7359 -0.781 0.382 N 0.463 0.263 0.37762505005 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/T 33508 Ig-158 13 rs758673294 0.7359 -0.781 0.382 N 0.463 0.263 0.37762505005 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/T 33508 Ig-158 13 rs758673294 0.7359 -0.781 0.382 N 0.463 0.263 0.37762505005 gnomAD-4.0.0 5.12777E-06 None None None None N None 0 0 None 0 0 None 0 0 7.1836E-06 0 2.84641E-05
Y/H 34270 Ig-161 13 rs1339846795 0.2894 0.51 0.997 N 0.579 0.478 0.427254322456 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
Y/H 34270 Ig-161 13 rs1339846795 0.2894 0.51 0.997 N 0.579 0.478 0.427254322456 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/H 34270 Ig-161 13 rs1339846795 0.2894 0.51 0.997 N 0.579 0.478 0.427254322456 gnomAD-4.0.0 6.57099E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
Y/S 34270 Ig-161 13 rs773071400 0.3069 -0.245 0.964 N 0.56 0.387 0.605049500696 gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
Y/S 34270 Ig-161 13 rs773071400 0.3069 -0.245 0.964 N 0.56 0.387 0.605049500696 gnomAD-4.0.0 3.18189E-06 None None None None N None 0 4.57268E-05 None 0 0 None 0 0 0 0 0
P/L 34954 Ig-163 13 rs1689198573 0.2982 None 1.0 N 0.783 0.437 0.769452518284 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/S 34954 Ig-163 13 None 0.3076 None 1.0 N 0.726 0.405 0.357313475932 gnomAD-4.0.0 1.59089E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85755E-06 0 0
Y/C 35141 Ig-164 13 None 0.1184 None 0.196 N 0.417 0.093 0.390220360785 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 35298 Ig-165 13 rs1038411721 0.0945 None None N 0.137 0.086 0.126345400529 gnomAD-4.0.0 1.59097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85758E-06 0 0
S/F 35432 Ig-166 13 None 0.1579 None 0.371 N 0.495 0.184 0.527098005314 gnomAD-4.0.0 6.84167E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99412E-07 0 0
S/Y 35432 Ig-166 13 rs773091136 0.1732 -0.858 0.371 N 0.498 0.22 0.551798466036 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/Y 35432 Ig-166 13 rs773091136 0.1732 -0.858 0.371 N 0.498 0.22 0.551798466036 gnomAD-4.0.0 6.84167E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15942E-05 0
N/H 35619 Ig-167 13 None 0.1008 None 0.196 N 0.33 0.031 0.139678290688 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
N/I 35619 Ig-167 13 None 0.1641 None 0.007 N 0.487 0.124 0.251639045875 gnomAD-4.0.0 6.84139E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99399E-06 0 0
N/K 35619 Ig-167 13 rs116604145 0.169 None 0.008 N 0.177 0.152 0.0401082797425 gnomAD-4.0.0 1.36828E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7988E-06 0 0
D/E 35909 Ig-169 13 rs1401685434 0.2657 None 0.001 N 0.24 0.111 0.0611884634855 gnomAD-3.1.2 1.31E-05 None None None -0.25(OBSL1) -0.412(OBSCN) N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
D/E 35909 Ig-169 13 rs1401685434 0.2657 None 0.001 N 0.24 0.111 0.0611884634855 gnomAD-4.0.0 3.04467E-06 None None None -0.25(OBSL1) -0.412(OBSCN) N None 5.24054E-05 0 None 0 0 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.