Structural position:

  • Domain Type: Ig
  • Aligned Position: 52
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
G/C 43 Ig-1 38 None 0.7821 None 1.0 D 0.699 0.666 0.899237815192 gnomAD-4.0.0 2.40064E-06 None None None -0.158(TCAP) N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
G/E 141 Ig-2 38 rs750730828 0.8987 -0.575 1.0 D 0.687 0.704 0.823491029573 gnomAD-2.1.1 2.83E-05 None None None 0.567(TCAP) N None 0 0 None 0 0 None 1.95976E-04 None 0 1.55E-05 0
G/E 141 Ig-2 38 rs750730828 0.8987 -0.575 1.0 D 0.687 0.704 0.823491029573 gnomAD-3.1.2 2.63E-05 None None None 0.567(TCAP) N None 0 0 0 0 0 None 0 0 2.94E-05 4.14422E-04 0
G/E 141 Ig-2 38 rs750730828 0.8987 -0.575 1.0 D 0.687 0.704 0.823491029573 gnomAD-4.0.0 1.61088E-05 None None None 0.567(TCAP) N None 0 0 None 0 2.22767E-05 None 0 0 5.08471E-06 1.9762E-04 1.60046E-05
G/R 141 Ig-2 38 rs758547822 0.9138 -0.266 0.974 D 0.517 0.757 0.823535708244 gnomAD-2.1.1 3.98E-06 None None None -0.016(TCAP) N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
G/R 141 Ig-2 38 rs758547822 0.9138 -0.266 0.974 D 0.517 0.757 0.823535708244 gnomAD-4.0.0 1.59049E-06 None None None -0.016(TCAP) N None 0 0 None 0 0 None 0 0 2.85647E-06 0 0
G/D 1119 Ig-4 38 None 0.6531 None 1.0 N 0.665 0.566 0.230578612272 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/S 1119 Ig-4 38 rs2092847521 0.2486 None 1.0 N 0.673 0.486 0.20549828249 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/D 1328 Ig-5 38 None 0.9886 None 1.0 N 0.658 0.568 0.318252033908 gnomAD-4.0.0 6.84208E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99357E-07 0 0
G/C 1494 Ig-6 38 rs774506028 0.6682 -0.536 1.0 D 0.726 0.875 0.923634717864 gnomAD-2.1.1 1.2E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 4.62E-05 8.83E-06 0
G/C 1494 Ig-6 38 rs774506028 0.6682 -0.536 1.0 D 0.726 0.875 0.923634717864 gnomAD-4.0.0 1.36828E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31932E-05 0
G/S 1494 Ig-6 38 rs774506028 0.1876 -0.203 1.0 D 0.672 0.776 0.626919690049 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.83E-06 0
G/S 1494 Ig-6 38 rs774506028 0.1876 -0.203 1.0 D 0.672 0.776 0.626919690049 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/S 1494 Ig-6 38 rs774506028 0.1876 -0.203 1.0 D 0.672 0.776 0.626919690049 gnomAD-4.0.0 2.47856E-06 None None None None I None 0 0 None 0 0 None 0 0 3.38999E-06 0 0
G/A 1742 Ig-8 40 None 0.6625 None 0.992 D 0.464 0.813 0.526437037968 gnomAD-4.0.0 1.59067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
G/R 1742 Ig-8 40 None 0.7939 None 0.999 D 0.717 0.686 0.826022559999 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
G/E 1878 Ig-9 38 rs745311218 0.7391 -0.771 0.999 N 0.717 0.488 0.343788945184 gnomAD-2.1.1 1.06E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.33E-05 0
G/E 1878 Ig-9 38 rs745311218 0.7391 -0.771 0.999 N 0.717 0.488 0.343788945184 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/E 1878 Ig-9 38 rs745311218 0.7391 -0.771 0.999 N 0.717 0.488 0.343788945184 gnomAD-4.0.0 1.30108E-05 None None None None I None 0 0 None 0 0 None 0 0 1.77964E-05 0 0
G/A 2115 Ig-10 38 None 0.5607 None 1.0 D 0.581 0.822 0.608622489738 gnomAD-4.0.0 1.59077E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
G/C 2115 Ig-10 38 rs1183661272 0.8625 None 1.0 D 0.703 0.866 0.854799818981 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/C 2115 Ig-10 38 rs1183661272 0.8625 None 1.0 D 0.703 0.866 0.854799818981 gnomAD-4.0.0 2.02997E-06 None None None None I None 1.74758E-05 0 None 0 0 None 0 0 1.20494E-06 0 0
G/S 2211 Ig-11 38 rs779819023 0.1045 -0.535 0.338 N 0.372 0.143 0.124217242631 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 5.45E-05 None 3.27E-05 None 0 0 0
G/S 2211 Ig-11 38 rs779819023 0.1045 -0.535 0.338 N 0.372 0.143 0.124217242631 gnomAD-4.0.0 3.18155E-06 None None None None N None 5.65547E-05 0 None 0 0 None 0 0 0 1.43271E-05 0
G/V 2211 Ig-11 38 None 0.3636 None 0.879 N 0.527 0.212 0.520963378925 gnomAD-4.0.0 1.59077E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
D/E 2303 Ig-12 37 None 0.1192 None 0.002 N 0.175 0.072 0.0551355673512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
D/G 2303 Ig-12 37 None 0.0577 None None N 0.212 0.104 0.0138822411134 gnomAD-4.0.0 1.59064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85687E-06 0 0
D/H 2303 Ig-12 37 rs779125886 0.1751 0.3 0.484 N 0.357 0.108 0.0551355673512 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
D/H 2303 Ig-12 37 rs779125886 0.1751 0.3 0.484 N 0.357 0.108 0.0551355673512 gnomAD-4.0.0 1.4366E-05 None None None None N None 0 0 None 0 0 None 0 0 1.8886E-05 0 0
G/S 2392 Ig-13 37 rs4894048 0.1174 -0.465 0.992 D 0.333 0.571 None gnomAD-2.1.1 6.77589E-02 None None None None N None 9.35647E-02 1.86914E-01 None 3.37068E-02 1.8974E-02 None 1.52349E-01 None 5.5821E-02 2.31968E-02 5.51858E-02
G/S 2392 Ig-13 37 rs4894048 0.1174 -0.465 0.992 D 0.333 0.571 None gnomAD-3.1.2 5.95038E-02 None None None None N None 9.19921E-02 1.38838E-01 0 3.14121E-02 1.6185E-02 None 5.7852E-02 2.8481E-02 2.22794E-02 1.46387E-01 4.1587E-02
G/S 2392 Ig-13 37 rs4894048 0.1174 -0.465 0.992 D 0.333 0.571 None 1000 genomes 8.74601E-02 None None None None N None 9.15E-02 1.599E-01 None None 1.49E-02 3.58E-02 None None None 1.585E-01 None
G/S 2392 Ig-13 37 rs4894048 0.1174 -0.465 0.992 D 0.333 0.571 None gnomAD-4.0.0 4.05323E-02 None None None None N None 9.24513E-02 1.72702E-01 None 3.34054E-02 1.023E-02 None 5.74388E-02 4.63543E-02 2.25323E-02 1.47326E-01 4.34678E-02
D/E 2569 Ig-15 37 rs2091797689 0.1276 None 0.027 N 0.251 0.1 0.16115917748 gnomAD-4.0.0 1.59094E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85688E-06 0 0
D/V 2569 Ig-15 37 None 0.324 None 0.484 N 0.415 0.202 0.239305524855 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/A 2744 Ig-17 38 rs556908341 0.3261 -0.369 1.0 D 0.575 0.653 0.747641037427 gnomAD-2.1.1 2.66747E-04 None None None None I None 0 2.89E-05 None 0 0 None 2.15588E-03 None 0 0 0
G/A 2744 Ig-17 38 rs556908341 0.3261 -0.369 1.0 D 0.575 0.653 0.747641037427 gnomAD-3.1.2 7.89E-05 None None None None I None 0 0 0 0 0 None 0 0 0 2.48653E-03 0
G/A 2744 Ig-17 38 rs556908341 0.3261 -0.369 1.0 D 0.575 0.653 0.747641037427 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 0 0 None None None 3.1E-03 None
G/A 2744 Ig-17 38 rs556908341 0.3261 -0.369 1.0 D 0.575 0.653 0.747641037427 gnomAD-4.0.0 1.19569E-04 None None None None I None 1.33259E-05 1.66617E-05 None 0 0 None 0 1.64962E-04 0 2.00922E-03 1.11989E-04
S/N 2831 Ig-18 37 rs2306636 0.0442 0.014 None N 0.079 0.138 None gnomAD-2.1.1 7.91051E-02 None None None None N None 1.15767E-02 2.39204E-01 None 5.69388E-02 2.02128E-01 None 4.1057E-02 None 5.32999E-02 4.57174E-02 6.68145E-02
S/N 2831 Ig-18 37 rs2306636 0.0442 0.014 None N 0.079 0.138 None gnomAD-3.1.2 5.16731E-02 None None None None N None 1.18726E-02 1.39565E-01 4.82456E-02 5.59723E-02 1.84913E-01 None 5.12361E-02 1.58228E-02 4.6592E-02 4.64345E-02 4.82792E-02
S/N 2831 Ig-18 37 rs2306636 0.0442 0.014 None N 0.079 0.138 None 1000 genomes 8.127E-02 None None None None N None 2.3E-03 1.729E-01 None None 1.905E-01 5.07E-02 None None None 4.19E-02 None
S/N 2831 Ig-18 37 rs2306636 0.0442 0.014 None N 0.079 0.138 None gnomAD-4.0.0 5.47099E-02 None None None None N None 1.09672E-02 2.05872E-01 None 5.52665E-02 1.92579E-01 None 5.40629E-02 1.96305E-02 4.57953E-02 4.17444E-02 5.42473E-02
G/A 2918 Ig-19 37 rs746575522 0.5984 -0.261 1.0 D 0.558 0.731 0.601359937655 gnomAD-2.1.1 1.06E-05 None None None None N None 0 0 None 0 0 None 0 None 1.19427E-04 0 0
G/A 2918 Ig-19 37 rs746575522 0.5984 -0.261 1.0 D 0.558 0.731 0.601359937655 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 1.89E-04 0 0 0 0
G/A 2918 Ig-19 37 rs746575522 0.5984 -0.261 1.0 D 0.558 0.731 0.601359937655 gnomAD-4.0.0 7.68397E-06 None None None None N None 0 0 None 0 0 None 9.4162E-05 0 0 0 0
G/R 2918 Ig-19 37 None 0.6646 None 1.0 D 0.65 0.812 0.871665977118 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/A 3005 Ig-20 37 None 0.6363 None 1.0 D 0.584 0.566 0.338110398507 gnomAD-4.0.0 6.84091E-07 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 0 0 0
G/D 3005 Ig-20 37 rs2090986560 0.5034 None 1.0 D 0.648 0.648 0.32580497728 gnomAD-4.0.0 4.78864E-06 None None None None N None 0 0 None 0 0 None 1.87203E-05 0 3.59719E-06 1.15934E-05 1.6559E-05
D/G 3094 Ig-21 37 rs1330654958 0.071 -0.21 None N 0.143 0.108 0.0138822411134 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
D/G 3094 Ig-21 37 rs1330654958 0.071 -0.21 None N 0.143 0.108 0.0138822411134 gnomAD-4.0.0 1.59054E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
D/N 3094 Ig-21 37 rs1228717391 0.0868 0.335 0.024 N 0.217 0.192 0.0551355673512 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
D/N 3094 Ig-21 37 rs1228717391 0.0868 0.335 0.024 N 0.217 0.192 0.0551355673512 gnomAD-4.0.0 1.59054E-06 None None None None N None 0 0 None 0 2.77454E-05 None 0 0 0 0 0
G/D 3183 Ig-22 37 rs772678867 0.6075 -0.467 1.0 N 0.677 0.523 0.149567049428 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.82E-06 0
G/D 3183 Ig-22 37 rs772678867 0.6075 -0.467 1.0 N 0.677 0.523 0.149567049428 gnomAD-4.0.0 4.10453E-06 None None None None I None 0 0 None 0 2.52054E-05 None 0 0 4.49654E-06 0 0
E/G 3276 Ig-23 38 rs377049518 0.0904 -0.039 0.193 N 0.391 0.203 None gnomAD-2.1.1 1.77E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.88E-05 0
E/G 3276 Ig-23 38 rs377049518 0.0904 -0.039 0.193 N 0.391 0.203 None gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 5.88E-05 0 0
E/G 3276 Ig-23 38 rs377049518 0.0904 -0.039 0.193 N 0.391 0.203 None gnomAD-4.0.0 8.85982E-05 None None None None N None 2.6693E-05 0 None 0 0 None 0 0 1.16948E-04 0 4.80092E-05
E/K 3276 Ig-23 38 rs929694215 0.1666 None 0.193 N 0.335 0.354 0.276065633971 gnomAD-4.0.0 3.18103E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85654E-06 1.43275E-05 0
Q/H 3502 Ig-25 38 None 0.2104 None None None None 0.058 None gnomAD-4.0.0 1.59111E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85804E-06 0 0
G/D 3697 Ig-26 38 rs1266849106 0.1365 None None None None 0.068 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
G/R 3697 Ig-26 38 rs2086945307 0.3159 None None None None 0.083 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
G/R 3697 Ig-26 38 rs2086945307 0.3159 None None None None 0.083 None gnomAD-4.0.0 2.56242E-06 None None None None I None 1.69262E-05 0 None 0 0 None 0 0 0 1.34005E-05 0
G/S 3697 Ig-26 38 None 0.1284 None None None None 0.091 None gnomAD-4.0.0 1.59126E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02425E-05
G/R 3857 Ig-27 38 rs777025488 0.321 -0.353 0.982 D 0.583 0.439 None gnomAD-4.0.0 1.27299E-05 None None None None I None 0 0 None 0 0 None 1.12952E-04 0 5.71651E-06 0 0
N/D 4641 Ig-29 36 None 0.0853 None None N 0.077 0.11 None gnomAD-4.0.0 1.59181E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85891E-06 0 0
N/I 4641 Ig-29 36 rs1297520971 0.2747 None 0.033 N 0.458 0.118 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/I 4641 Ig-29 36 rs1297520971 0.2747 None 0.033 N 0.458 0.118 None gnomAD-4.0.0 6.57082E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
N/S 4641 Ig-29 36 None 0.0685 None None N 0.066 0.113 None gnomAD-4.0.0 1.59184E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
G/C 4737 Ig-30 38 None 0.6997 None 1.0 D 0.764 0.536 0.647102547044 gnomAD-4.0.0 1.59177E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85858E-06 0 0
G/D 4832 Ig-31 38 rs1485727928 0.2416 -0.83 0.995 N 0.668 0.424 0.252681307341 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 1.53925E-04 None 0 None 0 0 0
G/D 4832 Ig-31 38 rs1485727928 0.2416 -0.83 0.995 N 0.668 0.424 0.252681307341 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92753E-04 None 0 0 0 0 0
G/D 4832 Ig-31 38 rs1485727928 0.2416 -0.83 0.995 N 0.668 0.424 0.252681307341 gnomAD-4.0.0 5.12409E-06 None None None None N None 0 0 None 0 7.27484E-05 None 0 0 0 0 2.84382E-05
G/A 4925 Ig-32 38 None 0.1673 None 1.0 N 0.549 0.432 0.219573609325 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85811E-06 0 0
N/S 5019 Ig-33 39 None 0.0936 None 0.826 N 0.297 0.188 0.104622674875 gnomAD-4.0.0 4.78995E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79899E-06 5.7971E-05 0
K/N 5112 Ig-34 38 None 0.4634 None 0.999 N 0.681 0.358 0.32714864917 gnomAD-4.0.0 4.77456E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.29997E-05 0
G/E 5298 Ig-36 38 rs1395880212 0.2948 -0.539 0.964 D 0.513 0.458 0.452928561435 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
G/E 5298 Ig-36 38 rs1395880212 0.2948 -0.539 0.964 D 0.513 0.458 0.452928561435 gnomAD-4.0.0 3.42103E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59789E-06 0 1.65656E-05
G/S 5394 Ig-37 38 None 0.1092 None 0.028 N 0.243 0.197 0.183819452728 gnomAD-4.0.0 3.18372E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71713E-06 0 0
N/D 5487 Ig-38 38 None 0.0575 None None N 0.083 0.053 0.0482279557977 gnomAD-4.0.0 6.8426E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99496E-07 0 0
N/H 5487 Ig-38 38 rs2080751190 0.1111 None 0.065 N 0.247 0.062 0.0806252709748 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/H 5487 Ig-38 38 rs2080751190 0.1111 None 0.065 N 0.247 0.062 0.0806252709748 gnomAD-4.0.0 1.23951E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69528E-06 0 0
N/K 5487 Ig-38 38 None 0.1285 None None N 0.088 0.119 0.0762999501168 gnomAD-4.0.0 1.59156E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8586E-06 0 0
N/S 5487 Ig-38 38 rs2080750786 0.0703 None 0.003 N 0.196 0.07 0.0401082797425 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30976E-04 0 0 0 None 0 0 0 0 0
N/S 5487 Ig-38 38 rs2080750786 0.0703 None 0.003 N 0.196 0.07 0.0401082797425 gnomAD-4.0.0 3.84387E-06 None None None None N None 0 3.39087E-05 None 0 0 None 0 0 2.39329E-06 0 0
D/N 5581 Ig-39 39 rs868601649 0.1047 None 0.989 N 0.449 0.286 0.166414681773 gnomAD-4.0.0 3.1824E-06 None None None None N None 0 0 None 0 0 None 0 2.41313E-04 2.85819E-06 0 0
D/V 5581 Ig-39 39 rs1051626873 0.35 0.136 0.997 N 0.568 0.539 0.583646370046 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/V 5581 Ig-39 39 rs1051626873 0.35 0.136 0.997 N 0.568 0.539 0.583646370046 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 5581 Ig-39 39 rs1051626873 0.35 0.136 0.997 N 0.568 0.539 0.583646370046 gnomAD-4.0.0 6.08957E-06 None None None None N None 0 0 None 0 0 None 0 0 7.22953E-06 0 0
D/Y 5581 Ig-39 39 None 0.2361 None 1.0 N 0.562 0.431 0.57809870819 gnomAD-4.0.0 1.5912E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
N/K 5674 Ig-40 38 rs1373550135 0.1987 0.47 0.27 N 0.303 0.113 0.0716867268079 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
N/K 5674 Ig-40 38 rs1373550135 0.1987 0.47 0.27 N 0.303 0.113 0.0716867268079 gnomAD-4.0.0 4.77403E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.29824E-05 0
S/G 5767 Ig-41 38 rs1204382084 0.074 0.011 0.005 N 0.167 0.084 0.0482279557977 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/G 5767 Ig-41 38 rs1204382084 0.074 0.011 0.005 N 0.167 0.084 0.0482279557977 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 5767 Ig-41 38 rs1204382084 0.074 0.011 0.005 N 0.167 0.084 0.0482279557977 gnomAD-4.0.0 6.57099E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
S/N 5767 Ig-41 38 rs200692495 0.0516 -0.038 None N 0.089 0.049 None gnomAD-2.1.1 3.99977E-04 None None None None N None 4.38125E-03 1.69952E-04 None 0 0 None 0 None 0 0 0
S/N 5767 Ig-41 38 rs200692495 0.0516 -0.038 None N 0.089 0.049 None gnomAD-3.1.2 9.92481E-04 None None None None N None 3.52453E-03 2.61849E-04 0 0 0 None 0 0 0 0 4.78011E-04
S/N 5767 Ig-41 38 rs200692495 0.0516 -0.038 None N 0.089 0.049 None 1000 genomes 1.39776E-03 None None None None N None 3.8E-03 2.9E-03 None None 0 0 None None None 0 None
S/N 5767 Ig-41 38 rs200692495 0.0516 -0.038 None N 0.089 0.049 None gnomAD-4.0.0 1.67933E-04 None None None None N None 3.23983E-03 1.5003E-04 None 0 0 None 0 0 4.2381E-06 0 2.241E-04
G/D 5860 Ig-42 38 rs754157651 0.1813 -0.507 0.898 N 0.557 0.392 0.242825505644 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 1.77E-05 0
G/D 5860 Ig-42 38 rs754157651 0.1813 -0.507 0.898 N 0.557 0.392 0.242825505644 gnomAD-4.0.0 4.78975E-06 None None None None N None 0 0 None 0 2.51978E-05 None 0 0 5.3971E-06 0 0
G/V 5860 Ig-42 38 None 0.5331 None 1.0 D 0.721 0.513 0.789514686668 gnomAD-4.0.0 6.8425E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
D/E 5956 Ig-43 38 rs879248826 0.1312 None 0.051 N 0.178 0.072 0.130388298395 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.45E-05 0 0 0 0
D/E 5956 Ig-43 38 rs879248826 0.1312 None 0.051 N 0.178 0.072 0.130388298395 gnomAD-4.0.0 1.36851E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
D/V 5956 Ig-43 38 rs1322586586 0.3027 0.135 0.966 N 0.44 0.341 0.474722520063 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/V 5956 Ig-43 38 rs1322586586 0.3027 0.135 0.966 N 0.44 0.341 0.474722520063 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
G/R 6143 Ig-45 39 rs757453585 0.2673 -0.411 1.0 D 0.702 0.527 0.73768680617 gnomAD-2.1.1 1.61E-05 None None None None N None 0 2.9E-05 None 0 0 None 6.54E-05 None 0 8.88E-06 0
G/R 6143 Ig-45 39 rs757453585 0.2673 -0.411 1.0 D 0.702 0.527 0.73768680617 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 6.55E-05 0 0 0 None 0 0 0 0 0
G/R 6143 Ig-45 39 rs757453585 0.2673 -0.411 1.0 D 0.702 0.527 0.73768680617 gnomAD-4.0.0 7.43716E-06 None None None None N None 4.0063E-05 3.33634E-05 None 0 0 None 0 0 2.54293E-06 4.39174E-05 0
N/D 6236 Ig-46 38 rs758455641 0.1268 0.43 0.642 N 0.333 0.161 0.0954503805726 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 3.56E-05 0
N/D 6236 Ig-46 38 rs758455641 0.1268 0.43 0.642 N 0.333 0.161 0.0954503805726 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/D 6236 Ig-46 38 rs758455641 0.1268 0.43 0.642 N 0.333 0.161 0.0954503805726 gnomAD-4.0.0 1.02511E-05 None None None None N None 0 0 None 0 0 None 1.56868E-05 0 1.43631E-05 0 2.84463E-05
D/N 6329 Ig-47 38 rs748054208 0.0778 0.202 0.993 N 0.623 0.305 0.213573922156 gnomAD-2.1.1 8.13E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.8E-05 0
D/N 6329 Ig-47 38 rs748054208 0.0778 0.202 0.993 N 0.623 0.305 0.213573922156 gnomAD-4.0.0 4.78127E-06 None None None None I None 0 0 None 0 0 None 0 0 8.58462E-06 0 0
D/V 6329 Ig-47 38 rs781304014 0.2803 0.162 0.997 N 0.657 0.55 0.482792760554 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 5.62E-05 None 0 None 0 0 0
D/V 6329 Ig-47 38 rs781304014 0.2803 0.162 0.997 N 0.657 0.55 0.482792760554 gnomAD-4.0.0 4.7808E-06 None None None None I None 0 0 None 0 5.56328E-05 None 0 0 2.86128E-06 0 0
G/R 6422 Ig-48 38 rs774524508 0.3704 -0.39 1.0 D 0.665 0.599 0.763780976484 gnomAD-2.1.1 2.51E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 1.20212E-04 1.57E-05 1.41243E-04
G/R 6422 Ig-48 38 rs774524508 0.3704 -0.39 1.0 D 0.665 0.599 0.763780976484 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
G/R 6422 Ig-48 38 rs774524508 0.3704 -0.39 1.0 D 0.665 0.599 0.763780976484 gnomAD-4.0.0 2.35562E-05 None None None None N None 2.67115E-05 0 None 0 0 None 6.25547E-05 0 2.54332E-05 0 3.2039E-05
G/R 6518 Ig-49 38 None 0.3057 None 0.928 N 0.547 0.447 0.546952355657 gnomAD-4.0.0 1.59247E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86017E-06 0 0
D/G 6611 Ig-50 38 None 0.0875 None 0.006 N 0.315 0.146 0.0762999501168 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 6611 Ig-50 38 None 0.0672 None 0.864 N 0.462 0.236 0.124217242631 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 6891 Ig-53 38 None 0.0955 None 0.999 N 0.593 0.167 0.213573922156 gnomAD-4.0.0 3.18539E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72145E-06 0 0
G/E 6985 Ig-54 38 None 0.3157 None 1.0 N 0.673 0.427 0.480801007081 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 6985 Ig-54 38 rs1451519377 0.362 -0.319 1.0 N 0.699 0.462 0.633723653509 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
G/R 6985 Ig-54 38 rs1451519377 0.362 -0.319 1.0 N 0.699 0.462 0.633723653509 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 1.88274E-05 0 0 0 0
A/V 7174 Ig-56 38 rs764832849 0.0996 -0.13 0.012 N 0.159 0.069 0.235664433957 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 1.66611E-04
A/V 7174 Ig-56 38 rs764832849 0.0996 -0.13 0.012 N 0.159 0.069 0.235664433957 gnomAD-3.1.2 5.92E-05 None None None None N None 0 3.93649E-04 0 0 0 None 0 0 4.41E-05 0 0
A/V 7174 Ig-56 38 rs764832849 0.0996 -0.13 0.012 N 0.159 0.069 0.235664433957 gnomAD-4.0.0 1.61169E-05 None None None None N None 0 1.50175E-04 None 0 0 None 0 0 1.44119E-05 0 0
G/D 7267 Ig-57 38 rs375627540 0.1487 -0.544 0.071 N 0.299 0.3 0.17258766438 gnomAD-2.1.1 6.15821E-04 None None None None N None 0 0 None 0 0 None 5.55882E-03 None 0 7.85E-06 1.40964E-04
G/D 7267 Ig-57 38 rs375627540 0.1487 -0.544 0.071 N 0.299 0.3 0.17258766438 gnomAD-3.1.2 2.6304E-04 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 7.66363E-03 0
G/D 7267 Ig-57 38 rs375627540 0.1487 -0.544 0.071 N 0.299 0.3 0.17258766438 1000 genomes 1.99681E-03 None None None None N None 0 0 None None 0 0 None None None 1.02E-02 None
G/D 7267 Ig-57 38 rs375627540 0.1487 -0.544 0.071 N 0.299 0.3 0.17258766438 gnomAD-4.0.0 3.51419E-04 None None None None N None 2.66667E-05 0 None 0 0 None 0 1.65125E-04 5.93406E-06 5.84204E-03 4.00218E-04
G/S 7267 Ig-57 38 rs772450876 0.1043 -0.839 0.961 N 0.377 0.395 0.223146558224 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
G/S 7267 Ig-57 38 rs772450876 0.1043 -0.839 0.961 N 0.377 0.395 0.223146558224 gnomAD-4.0.0 3.1841E-06 None None None None N None 0 0 None 0 5.55185E-05 None 0 0 0 0 0
G/V 7267 Ig-57 38 None 0.2963 None 0.994 D 0.561 0.418 0.707368253468 gnomAD-4.0.0 6.84334E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99569E-07 0 0
D/V 7360 Ig-58 38 None 0.1882 None 0.999 N 0.563 0.487 0.541875726618 gnomAD-4.0.0 1.36879E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79925E-06 0 0
G/E 7456 Ig-59 38 rs1318521268 0.3026 -0.528 0.999 D 0.648 0.517 0.85662319448 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/E 7456 Ig-59 38 rs1318521268 0.3026 -0.528 0.999 D 0.648 0.517 0.85662319448 gnomAD-4.0.0 1.59202E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
G/R 7456 Ig-59 38 rs1244883494 0.3586 -0.516 1.0 D 0.686 0.595 0.899589805243 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.46831E-04 None 0 None 0 0 0
G/R 7456 Ig-59 38 rs1244883494 0.3586 -0.516 1.0 D 0.686 0.595 0.899589805243 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93798E-04 None 0 0 0 0 0
G/R 7456 Ig-59 38 rs1244883494 0.3586 -0.516 1.0 D 0.686 0.595 0.899589805243 gnomAD-4.0.0 6.57687E-06 None None None None N None 0 0 None 0 1.93798E-04 None 0 0 0 0 0
N/D 7552 Ig-60 38 rs1171381654 0.1073 0.053 None N 0.122 0.106 0.168933306366 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/D 7552 Ig-60 38 rs1171381654 0.1073 0.053 None N 0.122 0.106 0.168933306366 gnomAD-4.0.0 1.59195E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43357E-05 0
R/G 7739 Ig-62 38 rs372250586 0.327 0.062 0.006 N 0.241 0.17 0.154104182512 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
R/G 7739 Ig-62 38 rs372250586 0.327 0.062 0.006 N 0.241 0.17 0.154104182512 gnomAD-4.0.0 1.23188E-05 None None None None N None 0 0 None 0 0 None 0 0 1.43941E-05 0 3.31488E-05
R/Q 7739 Ig-62 38 rs749882000 0.1745 0.044 0.966 N 0.427 0.123 0.115124310173 gnomAD-2.1.1 2.15E-05 None None None None N None 1.24131E-04 0 None 0 0 None 0 None 0 2.35E-05 0
R/Q 7739 Ig-62 38 rs749882000 0.1745 0.044 0.966 N 0.427 0.123 0.115124310173 gnomAD-3.1.2 7.23E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 1.02944E-04 0 0
R/Q 7739 Ig-62 38 rs749882000 0.1745 0.044 0.966 N 0.427 0.123 0.115124310173 gnomAD-4.0.0 1.17764E-05 None None None None N None 7.99979E-05 0 None 0 0 None 0 0 9.32537E-06 2.19674E-05 0
R/G 7832 Ig-63 38 rs2154300472 0.1074 None 0.006 N 0.268 0.087 0.211220785272 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.77555E-04
R/G 7832 Ig-63 38 rs2154300472 0.1074 None 0.006 N 0.268 0.087 0.211220785272 gnomAD-4.0.0 6.56409E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.7259E-04
R/I 7832 Ig-63 38 rs1300244680 0.2493 0.238 0.065 N 0.419 0.086 0.247872288689 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/I 7832 Ig-63 38 rs1300244680 0.2493 0.238 0.065 N 0.419 0.086 0.247872288689 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
R/I 7832 Ig-63 38 rs1300244680 0.2493 0.238 0.065 N 0.419 0.086 0.247872288689 gnomAD-4.0.0 3.84336E-06 None None None None N None 0 5.08423E-05 None 0 0 None 0 0 0 0 0
R/K 7832 Ig-63 38 None 0.061 None None N 0.191 0.08 0.0401082797425 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
G/E 7926 Ig-64 38 None 0.3028 None 0.987 N 0.665 0.398 0.450343601259 gnomAD-4.0.0 3.18284E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85879E-06 1.43279E-05 0
G/R 7926 Ig-64 38 rs1462977201 0.3099 -0.36 0.997 N 0.704 0.52 0.682544474797 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/R 7926 Ig-64 38 rs1462977201 0.3099 -0.36 0.997 N 0.704 0.52 0.682544474797 gnomAD-4.0.0 6.84239E-07 None None None None N None 2.98846E-05 0 None 0 0 None 0 0 0 0 0
G/V 7926 Ig-64 38 None 0.7071 None 0.987 D 0.699 0.46 0.761581445113 gnomAD-4.0.0 1.59142E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
S/I 8115 Ig-66 38 None 0.1438 None 0.003 N 0.201 0.258 0.335910606209 gnomAD-4.0.0 1.36847E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79898E-06 0 0
S/N 8115 Ig-66 38 rs397517506 0.1073 0.161 0.001 N 0.115 0.073 0.0666544352282 gnomAD-2.1.1 8.86E-05 None None None None I None 0 2.32072E-04 None 3.98804E-04 0 None 3.27E-05 None 0 6.23E-05 3.32336E-04
S/N 8115 Ig-66 38 rs397517506 0.1073 0.161 0.001 N 0.115 0.073 0.0666544352282 gnomAD-3.1.2 3.94E-05 None None None None I None 0 1.30993E-04 0 0 0 None 0 0 5.88E-05 0 0
S/N 8115 Ig-66 38 rs397517506 0.1073 0.161 0.001 N 0.115 0.073 0.0666544352282 gnomAD-4.0.0 4.64801E-05 None None None None I None 0 1.5004E-04 None 6.08108E-04 0 None 0 0 3.39057E-05 1.09796E-05 1.12086E-04
E/K 8208 Ig-67 38 rs190192954 0.079 0.453 0.331 N 0.26 0.261 None gnomAD-2.1.1 5.72E-05 None None None None I None 5.37412E-04 5.66E-05 None 0 0 None 0 None 0 7.83E-06 0
E/K 8208 Ig-67 38 rs190192954 0.079 0.453 0.331 N 0.26 0.261 None gnomAD-3.1.2 1.44645E-04 None None None None I None 4.34573E-04 1.96515E-04 0 0 0 None 0 0 0 0 4.77555E-04
E/K 8208 Ig-67 38 rs190192954 0.079 0.453 0.331 N 0.26 0.261 None 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
E/K 8208 Ig-67 38 rs190192954 0.079 0.453 0.331 N 0.26 0.261 None gnomAD-4.0.0 3.16047E-05 None None None None I None 5.19986E-04 8.33361E-05 None 0 0 None 0 0 3.39064E-06 0 4.80215E-05
H/L 8301 Ig-68 38 rs763397399 0.153 0.711 0.01 N 0.287 0.393 0.554235320232 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/L 8301 Ig-68 38 rs763397399 0.153 0.711 0.01 N 0.287 0.393 0.554235320232 gnomAD-4.0.0 1.59372E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02499E-05
H/N 8301 Ig-68 38 rs375389220 0.0441 0.09 0.002 N 0.209 0.23 0.190952846119 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
H/N 8301 Ig-68 38 rs375389220 0.0441 0.09 0.002 N 0.209 0.23 0.190952846119 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
H/N 8301 Ig-68 38 rs375389220 0.0441 0.09 0.002 N 0.209 0.23 0.190952846119 gnomAD-4.0.0 6.56901E-06 None None None None N None 0 0 None 0 1.9305E-04 None 0 0 0 0 0
H/Y 8301 Ig-68 38 rs375389220 0.1121 0.925 0.178 N 0.4 0.275 0.332133492242 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
H/Y 8301 Ig-68 38 rs375389220 0.1121 0.925 0.178 N 0.4 0.275 0.332133492242 gnomAD-4.0.0 2.05425E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69856E-06 0 0
G/V 8397 Ig-69 38 rs1371524855 0.6949 None 0.985 D 0.453 0.387 0.674180029473 gnomAD-4.0.0 4.77629E-06 None None None None N None 0 0 None 0 5.55155E-05 None 0 0 0 1.43373E-05 0
N/I 8493 Ig-70 38 None 0.3522 None 0.993 N 0.42 0.355 0.380564188046 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 8493 Ig-70 38 None 0.3337 None 0.946 N 0.327 0.192 0.181679512989 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85904E-06 0 0
E/D 8587 Ig-71 39 rs2077371991 0.1084 None None N 0.145 0.068 0.0920862733494 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86004E-06 0 0
E/K 8587 Ig-71 39 rs760340908 0.1584 -0.022 0.659 N 0.37 0.224 0.20549828249 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 8.91E-06 0
E/K 8587 Ig-71 39 rs760340908 0.1584 -0.022 0.659 N 0.37 0.224 0.20549828249 gnomAD-4.0.0 1.09508E-05 None None None None N None 2.98936E-05 0 None 0 2.52181E-05 None 0 0 1.07962E-05 0 3.31422E-05
E/Q 8587 Ig-71 39 rs760340908 0.1848 -0.464 0.384 N 0.39 0.173 0.18995819373 gnomAD-2.1.1 4.03E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
E/Q 8587 Ig-71 39 rs760340908 0.1848 -0.464 0.384 N 0.39 0.173 0.18995819373 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 8587 Ig-71 39 rs760340908 0.1848 -0.464 0.384 N 0.39 0.173 0.18995819373 gnomAD-4.0.0 6.57609E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
K/N 8773 Ig-73 38 None 0.3031 None 0.007 N 0.277 0.031 0.0401082797425 gnomAD-4.0.0 3.42147E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49769E-06 0 0
G/E 8867 Ig-74 38 rs369142169 0.1901 -0.305 0.957 N 0.689 0.368 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
G/E 8867 Ig-74 38 rs369142169 0.1901 -0.305 0.957 N 0.689 0.368 None gnomAD-4.0.0 4.79016E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29678E-06 0 0
G/R 8867 Ig-74 38 rs762113080 0.1793 -0.355 0.978 N 0.721 0.47 0.614872044281 gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.47E-05 0
G/R 8867 Ig-74 38 rs762113080 0.1793 -0.355 0.978 N 0.721 0.47 0.614872044281 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/R 8867 Ig-74 38 rs762113080 0.1793 -0.355 0.978 N 0.721 0.47 0.614872044281 gnomAD-4.0.0 5.39214E-05 None None None None N None 0 0 None 0 0 None 0 0 7.37472E-05 0 0
G/V 8963 Ig-75 38 rs1225996636 0.3387 -0.296 0.015 D 0.403 0.438 0.550675598306 gnomAD-4.0.0 1.59306E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86095E-06 0 0
S/N 9056 Ig-76 38 None 0.1045 None 0.002 N 0.148 0.083 0.0716867268079 gnomAD-4.0.0 6.84251E-07 None None None None N None 0 0 None 0 2.52042E-05 None 0 0 0 0 0
G/A 9149 Ig-77 38 rs755633188 0.2918 -0.535 0.998 N 0.482 0.449 0.324986149311 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/A 9149 Ig-77 38 rs755633188 0.2918 -0.535 0.998 N 0.482 0.449 0.324986149311 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/A 9149 Ig-77 38 rs755633188 0.2918 -0.535 0.998 N 0.482 0.449 0.324986149311 gnomAD-4.0.0 3.09859E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23801E-06 0 0
G/D 9149 Ig-77 38 rs755633188 0.1902 None 1.0 N 0.728 0.406 0.337868961071 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
G/D 9149 Ig-77 38 rs755633188 0.1902 None 1.0 N 0.728 0.406 0.337868961071 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 9149 Ig-77 38 rs755633188 0.1902 None 1.0 N 0.728 0.406 0.337868961071 gnomAD-4.0.0 1.23944E-06 None None None None N None 0 1.66778E-05 None 0 0 None 0 0 8.47601E-07 0 0
G/V 9149 Ig-77 38 None 0.5721 None 1.0 D 0.739 0.565 0.638019369227 gnomAD-4.0.0 6.84202E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99454E-07 0 0
D/Y 9242 Ig-78 38 rs746470885 0.2689 0.133 1.0 N 0.552 0.388 0.530409124356 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
D/Y 9242 Ig-78 38 rs746470885 0.2689 0.133 1.0 N 0.552 0.388 0.530409124356 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
D/Y 9242 Ig-78 38 rs746470885 0.2689 0.133 1.0 N 0.552 0.388 0.530409124356 gnomAD-4.0.0 5.08171E-05 None None None None N None 1.33518E-05 0 None 0 0 None 0 0 6.78087E-05 0 1.60138E-05
G/S 9338 Ig-79 38 rs373598759 0.1347 -0.74 0.992 None 0.563 0.353 None gnomAD-2.1.1 2.81E-05 None None None None N None 6.46E-05 2.9E-05 None 0 5.56E-05 None 0 None 0 3.54E-05 0
G/S 9338 Ig-79 38 rs373598759 0.1347 -0.74 0.992 None 0.563 0.353 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/S 9338 Ig-79 38 rs373598759 0.1347 -0.74 0.992 None 0.563 0.353 None gnomAD-4.0.0 3.96609E-05 None None None None N None 6.67717E-05 1.66711E-05 None 0 2.22787E-05 None 0 0 4.83132E-05 0 0
S/I 9434 Ig-80 38 rs751432055 0.1938 -0.065 0.065 None 0.43 0.079 0.17948927462 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
S/I 9434 Ig-80 38 rs751432055 0.1938 -0.065 0.065 None 0.43 0.079 0.17948927462 gnomAD-4.0.0 1.36832E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79884E-06 0 0
S/R 9434 Ig-80 38 None 0.2397 None 0.007 None 0.281 0.042 0.143124449307 gnomAD-4.0.0 1.59099E-06 None None None None N None 0 0 None 0 2.77254E-05 None 0 0 0 0 0
N/T 9531 Ig-81 39 rs537464608 0.4217 None 0.959 None 0.311 0.35 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/T 9531 Ig-81 39 rs537464608 0.4217 None 0.959 None 0.311 0.35 None gnomAD-4.0.0 2.56183E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78549E-06 0 0
G/D 9627 Ig-82 38 rs878908638 0.6741 -0.18 0.994 None 0.381 0.475 0.31501682445 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
G/D 9627 Ig-82 38 rs878908638 0.6741 -0.18 0.994 None 0.381 0.475 0.31501682445 gnomAD-4.0.0 2.73669E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59769E-06 0 0
K/N 9735 Ig-83 38 rs760884958 0.9507 0.25 1.0 None 0.702 0.165 0.128392430309 gnomAD-2.1.1 4.01E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/N 9735 Ig-83 38 rs760884958 0.9507 0.25 1.0 None 0.702 0.165 0.128392430309 gnomAD-4.0.0 6.84189E-07 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 0 0 0
T/S 9938 Ig-84 39 rs72650006 0.4829 -0.128 0.146 None 0.341 0.101 0.12205267543 gnomAD-2.1.1 1.93526E-02 None None None None N None 4.09494E-03 1.50795E-02 None 1.74907E-02 1.03788E-04 None 1.56817E-02 None 2.57932E-02 2.60036E-02 2.19671E-02
T/S 9938 Ig-84 39 rs72650006 0.4829 -0.128 0.146 None 0.341 0.101 0.12205267543 gnomAD-3.1.2 1.91004E-02 None None None None N None 5.089E-03 2.82031E-02 3.28947E-03 1.38488E-02 1.9253E-04 None 2.50329E-02 2.21519E-02 2.66524E-02 1.65769E-02 2.25096E-02
T/S 9938 Ig-84 39 rs72650006 0.4829 -0.128 0.146 None 0.341 0.101 0.12205267543 1000 genomes 1.05831E-02 None None None None N None 0 1.87E-02 None None 0 2.88E-02 None None None 1.12E-02 None
T/S 9938 Ig-84 39 rs72650006 0.4829 -0.128 0.146 None 0.341 0.101 0.12205267543 gnomAD-4.0.0 2.18754E-02 None None None None N None 4.48998E-03 1.92642E-02 None 1.54992E-02 1.11433E-04 None 2.68728E-02 2.24571E-02 2.44015E-02 1.57653E-02 2.02423E-02
G/S 10025 Ig-85 37 None 0.2136 None 0.991 None 0.539 0.49 0.267299060538 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
G/V 10025 Ig-85 37 None 0.9112 None 1.0 None 0.739 0.573 0.876304189171 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/A 10114 Ig-86 37 None 0.2461 None 0.454 None 0.298 0.118 0.0846915920261 gnomAD-4.0.0 1.36827E-06 None None None None N None 0 0 None 0 0 None 0 1.7337E-04 0 0 1.65634E-05
P/S 10114 Ig-86 37 None 0.3556 None 0.454 None 0.286 0.135 0.0806252709748 gnomAD-4.0.0 4.1048E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39633E-06 0 0
G/D 13723 Ig-87 40 None 0.4769 None 1.0 N 0.673 0.435 0.32306181527 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
G/S 13723 Ig-87 40 rs188301588 0.2279 -0.467 1.0 D 0.7 0.536 None gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 6.24E-05 0
G/S 13723 Ig-87 40 rs188301588 0.2279 -0.467 1.0 D 0.7 0.536 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 3.87747E-04 None 0 0 0 0 0
G/S 13723 Ig-87 40 rs188301588 0.2279 -0.467 1.0 D 0.7 0.536 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
G/S 13723 Ig-87 40 rs188301588 0.2279 -0.467 1.0 D 0.7 0.536 None gnomAD-4.0.0 1.85937E-05 None None None None N None 0 1.6675E-05 None 0 6.70151E-05 None 0 0 1.94981E-05 3.29424E-05 0
G/R 13816 Ig-88 37 None 0.7302 None 1.0 N 0.754 0.382 0.229264304666 gnomAD-4.0.0 3.18511E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72023E-06 0 0
G/S 13816 Ig-88 37 rs1422135009 0.2893 None 1.0 N 0.687 0.425 0.17258766438 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.94024E-04 None 0 0 0 0 0
G/S 13816 Ig-88 37 rs1422135009 0.2893 None 1.0 N 0.687 0.425 0.17258766438 gnomAD-4.0.0 5.12839E-06 None None None None I None 0 0 None 0 7.30959E-05 None 0 0 2.39454E-06 0 0
Y/C 13910 Ig-89 35 rs1469876306 0.3279 None 0.985 N 0.345 0.23 0.394079506076 gnomAD-4.0.0 1.64326E-06 None None None None N None 0 0 None 0 0 None 0 0 2.94994E-06 0 0
G/A 14001 Ig-90 37 None 0.8644 None 0.996 D 0.605 0.509 0.256283259241 gnomAD-4.0.0 1.59325E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86121E-06 0 0
G/R 14001 Ig-90 37 rs866553786 0.9818 -0.547 0.822 D 0.545 0.462 0.328222422547 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
G/R 14001 Ig-90 37 rs866553786 0.9818 -0.547 0.822 D 0.545 0.462 0.328222422547 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
G/R 14001 Ig-90 37 rs866553786 0.9818 -0.547 0.822 D 0.545 0.462 0.328222422547 gnomAD-4.0.0 2.56512E-06 None None None None I None 0 1.69866E-05 None 0 0 None 0 0 0 1.34253E-05 0
P/H 14089 Ig-91 36 rs201340186 0.2252 0.057 0.693 N 0.301 0.137 None gnomAD-2.1.1 2.86E-05 None None None None I None 0 0 None 0 0 None 0 None 1.59898E-04 2.35E-05 1.40687E-04
P/H 14089 Ig-91 36 rs201340186 0.2252 0.057 0.693 N 0.301 0.137 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 1.89143E-04 0 0 0 0
P/H 14089 Ig-91 36 rs201340186 0.2252 0.057 0.693 N 0.301 0.137 None gnomAD-4.0.0 8.97489E-06 None None None None I None 0 0 None 0 0 None 6.28062E-05 0 4.7892E-06 0 2.84689E-05
D/N 14178 Ig-92 37 None 0.1024 None 0.997 N 0.45 0.33 0.168933306366 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
G/D 14266 Ig-93 36 None 0.1718 None 0.984 N 0.519 0.423 0.290962096972 gnomAD-4.0.0 1.36876E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
G/S 14266 Ig-93 36 rs896263032 0.1342 None 0.992 D 0.488 0.434 0.304108284078 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/S 14266 Ig-93 36 rs896263032 0.1342 None 0.992 D 0.488 0.434 0.304108284078 gnomAD-4.0.0 2.56364E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78799E-06 0 0
G/E 14355 Ig-94 37 None 0.3797 None 0.974 D 0.763 0.366 0.28722502521 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
T/N 14444 Ig-95 37 rs1411904036 0.1173 0.147 None N 0.225 0.321 0.292423486923 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
T/N 14444 Ig-95 37 rs1411904036 0.1173 0.147 None N 0.225 0.321 0.292423486923 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
D/E 14533 Ig-96 37 None 0.2316 None 0.008 N 0.166 0.326 0.257786959452 gnomAD-4.0.0 1.37225E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80198E-06 0 0
D/G 14533 Ig-96 37 None 0.1526 None 0.722 N 0.401 0.471 0.292062946507 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/E 15067 Ig-102 37 rs745901229 0.1571 0.005 0.767 N 0.321 0.435 0.327952845175 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
D/E 15067 Ig-102 37 rs745901229 0.1571 0.005 0.767 N 0.321 0.435 0.327952845175 gnomAD-4.0.0 1.16392E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52984E-05 0 0
D/N 15067 Ig-102 37 rs370904881 0.0934 0.377 0.999 D 0.703 0.447 None gnomAD-2.1.1 5.74E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.25988E-04 0
D/N 15067 Ig-102 37 rs370904881 0.0934 0.377 0.999 D 0.703 0.447 None gnomAD-3.1.2 3.95E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 7.37E-05 0 0
D/N 15067 Ig-102 37 rs370904881 0.0934 0.377 0.999 D 0.703 0.447 None gnomAD-4.0.0 9.36528E-05 None None None None N None 1.33729E-05 0 None 3.38364E-05 0 None 0 1.64636E-04 1.17886E-04 0 1.44263E-04
D/V 15067 Ig-102 37 None 0.2724 None 0.999 D 0.727 0.676 0.886516015246 gnomAD-4.0.0 2.05401E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79983E-06 0 1.65837E-05
D/G 15156 Ig-103 37 rs1171217657 0.1778 0.081 0.865 N 0.561 0.181 0.126345400529 gnomAD-2.1.1 7.18E-06 None None None None N None 0 0 None 0 5.2E-05 None 0 None 0 7.86E-06 0
D/G 15156 Ig-103 37 rs1171217657 0.1778 0.081 0.865 N 0.561 0.181 0.126345400529 gnomAD-4.0.0 2.0543E-06 None None None None N None 0 0 None 0 5.06817E-05 None 0 0 8.9991E-07 0 0
D/N 15156 Ig-103 37 rs1375058579 0.1158 None 0.039 N 0.283 0.135 0.117506650769 gnomAD-4.0.0 6.16297E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09926E-06 0 0
E/A 15244 Ig-104 37 rs759829017 0.1804 0.092 0.027 N 0.335 0.108 0.165133752707 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
E/A 15244 Ig-104 37 rs759829017 0.1804 0.092 0.027 N 0.335 0.108 0.165133752707 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 15244 Ig-104 37 rs759829017 0.1804 0.092 0.027 N 0.335 0.108 0.165133752707 gnomAD-4.0.0 5.13219E-06 None None None None N None 0 0 None 0 0 None 0 0 9.58672E-06 0 0
G/S 15338 Ig-105 37 None 0.2283 None 1.0 D 0.673 0.546 0.223847106136 gnomAD-4.0.0 6.84774E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0002E-07 0 0
G/E 15427 Ig-106 37 rs775511280 0.7957 -0.744 1.0 D 0.642 0.633 0.77169317571 gnomAD-2.1.1 5.3E-06 None None None None N None 0 0 None 0 0 None 6.08E-05 None 0 0 0
G/E 15427 Ig-106 37 rs775511280 0.7957 -0.744 1.0 D 0.642 0.633 0.77169317571 gnomAD-4.0.0 1.44321E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.80214E-05 0
G/R 15427 Ig-106 37 rs760535484 0.8203 -0.462 1.0 D 0.677 0.637 0.814982974235 gnomAD-2.1.1 1.83E-05 None None None None N None 8.56E-05 0 None 0 0 None 1.22594E-04 None 0 0 0
G/R 15427 Ig-106 37 rs760535484 0.8203 -0.462 1.0 D 0.677 0.637 0.814982974235 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 2.07555E-04 0
G/R 15427 Ig-106 37 rs760535484 0.8203 -0.462 1.0 D 0.677 0.637 0.814982974235 gnomAD-4.0.0 9.7598E-06 None None None None N None 2.77793E-05 0 None 0 0 None 0 0 0 1.70801E-04 0
N/K 15605 Ig-108 38 rs777985762 0.1581 0.42 0.669 N 0.279 0.107 0.110078149338 gnomAD-2.1.1 8.1E-06 None None None None N None 6.48E-05 0 None 0 0 None 3.27E-05 None 0 0 0
N/K 15605 Ig-108 38 rs777985762 0.1581 0.42 0.669 N 0.279 0.107 0.110078149338 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
N/K 15605 Ig-108 38 rs777985762 0.1581 0.42 0.669 N 0.279 0.107 0.110078149338 gnomAD-4.0.0 1.8613E-06 None None None None N None 1.33736E-05 0 None 0 0 None 0 0 0 1.09864E-05 1.60416E-05
N/S 15605 Ig-108 38 None 0.0765 None 0.136 N 0.135 0.067 0.104622674875 gnomAD-4.0.0 3.19062E-06 None None None None N None 0 0 None 0 2.79096E-05 None 0 0 0 1.43402E-05 0
D/H 16000 Ig-109 33 rs201388509 0.2929 0.361 0.667 N 0.421 0.318 None gnomAD-2.1.1 8.75393E-04 None None None None N None 1.24121E-04 3.97118E-04 None 0 0 None 0 None 1.87895E-03 1.34673E-03 1.26796E-03
D/H 16000 Ig-109 33 rs201388509 0.2929 0.361 0.667 N 0.421 0.318 None gnomAD-3.1.2 4.74002E-04 None None None None N None 7.25E-05 0 0 0 0 None 1.22411E-03 0 8.24451E-04 0 0
D/H 16000 Ig-109 33 rs201388509 0.2929 0.361 0.667 N 0.421 0.318 None gnomAD-4.0.0 6.67874E-04 None None None None N None 9.35829E-05 2.50509E-04 None 3.38364E-05 0 None 1.76546E-03 0 7.53889E-04 0 8.33467E-04
G/V 16992 Ig-111 38 rs1280875443 0.5458 -0.278 1.0 D 0.687 0.525 0.704002560614 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
G/V 16992 Ig-111 38 rs1280875443 0.5458 -0.278 1.0 D 0.687 0.525 0.704002560614 gnomAD-4.0.0 1.5934E-06 None None None None N None 0 0 None 0 2.78707E-05 None 0 0 0 0 0
E/A 17285 Ig-112 35 None 0.1676 None None N 0.211 0.198 0.203808441222 gnomAD-4.0.0 1.36947E-06 None None None None N None 2.99365E-05 0 None 0 0 None 0 1.73792E-04 0 0 0
E/G 17285 Ig-112 35 None 0.0865 None 0.024 N 0.387 0.192 0.151104730317 gnomAD-4.0.0 6.84734E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16009E-05 0
E/K 17285 Ig-112 35 rs1355045941 0.1232 0.309 0.024 N 0.452 0.177 0.184867976434 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/K 17285 Ig-112 35 rs1355045941 0.1232 0.309 0.024 N 0.452 0.177 0.184867976434 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 17285 Ig-112 35 rs1355045941 0.1232 0.309 0.024 N 0.452 0.177 0.184867976434 gnomAD-4.0.0 2.56677E-06 None None None None N None 0 1.69716E-05 None 0 0 None 0 0 2.39686E-06 0 0
E/D 17710 Ig-113 34 rs749551895 0.0829 -0.084 None N 0.135 0.104 0.0666544352282 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
E/D 17710 Ig-113 34 rs749551895 0.0829 -0.084 None N 0.135 0.104 0.0666544352282 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 17710 Ig-113 34 rs749551895 0.0829 -0.084 None N 0.135 0.104 0.0666544352282 gnomAD-4.0.0 6.57964E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
G/R 18416 Ig-115 35 rs749556953 0.6683 -0.179 1.0 N 0.786 0.514 0.559427399277 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
P/L 18722 Ig-116 35 rs1480758213 0.1056 -0.477 0.007 N 0.309 0.146 0.413241256734 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/E 20116 Ig-120 37 None 0.1841 None 0.338 N 0.464 0.317 0.379881503574 gnomAD-4.0.0 2.40064E-06 None None None None N None 6.33473E-05 0 None 0 2.75482E-04 None 0 0 0 0 0
G/D 20514 Ig-121 36 rs1449445104 0.2154 -0.375 0.121 N 0.259 0.262 0.149567049428 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.98E-06 0
G/D 20514 Ig-121 36 rs1449445104 0.2154 -0.375 0.121 N 0.259 0.262 0.149567049428 gnomAD-4.0.0 1.5982E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86822E-06 0 0
G/S 20514 Ig-121 36 rs769107925 0.1486 -0.536 0.978 N 0.336 0.432 0.222439326576 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.98E-06 0
G/S 20514 Ig-121 36 rs769107925 0.1486 -0.536 0.978 N 0.336 0.432 0.222439326576 gnomAD-4.0.0 1.59831E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86837E-06 0 0
G/V 20514 Ig-121 36 rs1449445104 0.5812 -0.16 0.997 N 0.612 0.464 0.719121032051 gnomAD-2.1.1 8.14E-06 None None None None I None 0 0 None 1.02082E-04 0 None 0 None 0 8.98E-06 0
G/V 20514 Ig-121 36 rs1449445104 0.5812 -0.16 0.997 N 0.612 0.464 0.719121032051 gnomAD-4.0.0 3.19641E-06 None None None None I None 0 0 None 4.81974E-05 0 None 0 0 2.86822E-06 0 0
K/Q 20807 Ig-122 39 None 0.1445 None 0.864 N 0.601 0.159 0.287603790349 gnomAD-4.0.0 1.59258E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86077E-06 0 0
K/R 20807 Ig-122 39 rs1361295739 0.078 0.266 0.006 N 0.314 0.073 0.222439326576 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
K/R 20807 Ig-122 39 rs1361295739 0.078 0.266 0.006 N 0.314 0.073 0.222439326576 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 20807 Ig-122 39 rs1361295739 0.078 0.266 0.006 N 0.314 0.073 0.222439326576 gnomAD-4.0.0 6.57531E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47098E-05 0 0
G/S 21212 Ig-123 36 rs1381842230 0.2539 -0.742 1.0 N 0.687 0.527 0.341460817117 gnomAD-4.0.0 1.3691E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99722E-07 0 1.65766E-05
G/D 21901 Ig-125 36 None 0.1619 None 0.001 N 0.257 0.13 0.0762999501168 gnomAD-4.0.0 6.85271E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6597E-05
E/K 22588 Ig-127 29 None 0.1082 None 0.978 N 0.49 0.312 0.309530620856 gnomAD-4.0.0 1.59225E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85995E-06 0 0
N/D 23382 Ig-129 38 None 0.0668 None None N 0.12 0.102 0.0401082797425 gnomAD-4.0.0 1.59643E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87145E-06 0 0
D/A 23671 Ig-130 35 None 0.1251 None 0.543 N 0.372 0.188 0.274366138417 gnomAD-4.0.0 1.59315E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.027E-05
D/E 23671 Ig-130 35 None 0.0861 None 0.543 N 0.299 0.065 0.115124310173 gnomAD-4.0.0 6.84562E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99724E-07 0 0
D/H 23671 Ig-130 35 None 0.1939 None 1.0 N 0.459 0.418 0.211220785272 gnomAD-4.0.0 6.84586E-07 None None None None I None 2.98972E-05 0 None 0 0 None 0 0 0 0 0
D/N 23671 Ig-130 35 rs774191400 0.0744 0.386 0.998 N 0.515 0.257 0.139678290688 gnomAD-2.1.1 4.04E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
D/N 23671 Ig-130 35 rs774191400 0.0744 0.386 0.998 N 0.515 0.257 0.139678290688 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
D/N 23671 Ig-130 35 rs774191400 0.0744 0.386 0.998 N 0.515 0.257 0.139678290688 gnomAD-4.0.0 1.86016E-06 None None None None I None 2.67215E-05 0 None 0 0 None 0 0 8.47882E-07 0 0
H/N 24466 Ig-132 36 rs756789484 0.0498 0.221 0.002 N 0.205 0.097 0.101711395817 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
H/Q 24466 Ig-132 36 rs375373437 0.0925 0.289 0.642 N 0.297 0.174 0.0666544352282 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
H/R 24466 Ig-132 36 None 0.0772 None 0.473 N 0.227 0.28 0.158396225186 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
N/K 24753 Ig-133 38 None 0.1736 None 0.029 N 0.191 0.088 0.0138822411134 gnomAD-4.0.0 6.84323E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
D/V 25149 Ig-134 39 None 0.1237 None 0.317 N 0.456 0.232 0.326616659874 gnomAD-4.0.0 1.59177E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85941E-06 0 0
D/V 25548 Ig-135 35 None 0.2285 None 0.983 N 0.634 0.459 0.410603549233 gnomAD-4.0.0 1.59375E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86334E-06 0 0
G/D 25835 Ig-136 38 None 0.1291 None 0.004 N 0.297 0.107 0.0884992946249 gnomAD-4.0.0 1.5921E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85994E-06 0 0
E/D 26630 Ig-138 37 None 0.0644 None 0.002 N 0.196 0.069 0.104622674875 gnomAD-4.0.0 1.36852E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79907E-06 0 0
G/E 27313 Ig-140 36 rs199670463 0.1676 -0.493 1.0 N 0.713 0.421 0.456830177556 gnomAD-2.1.1 5.83301E-04 None None None None N None 0 0 None 0 0 None 5.13072E-03 None 0 3.92E-05 1.40528E-04
G/E 27313 Ig-140 36 rs199670463 0.1676 -0.493 1.0 N 0.713 0.421 0.456830177556 gnomAD-3.1.2 2.16974E-04 None None None None N None 2.41E-05 0 0 0 0 None 0 0 7.35E-05 5.59238E-03 0
G/E 27313 Ig-140 36 rs199670463 0.1676 -0.493 1.0 N 0.713 0.421 0.456830177556 1000 genomes 1.39776E-03 None None None None N None 0 0 None None 0 0 None None None 7.2E-03 None
G/E 27313 Ig-140 36 rs199670463 0.1676 -0.493 1.0 N 0.713 0.421 0.456830177556 gnomAD-4.0.0 3.30932E-04 None None None None N None 2.66596E-05 0 None 0 0 None 0 0 5.08584E-05 4.9406E-03 3.52146E-04
G/R 27313 Ig-140 36 rs786205298 0.2184 None 1.0 N 0.709 0.494 0.632259734576 gnomAD-4.0.0 6.84274E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99478E-07 0 0
G/C 28000 Ig-142 38 rs1335831025 0.3143 -0.944 1.0 D 0.744 0.541 0.715437530537 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
G/C 28000 Ig-142 38 rs1335831025 0.3143 -0.944 1.0 D 0.744 0.541 0.715437530537 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
G/C 28000 Ig-142 38 rs1335831025 0.3143 -0.944 1.0 D 0.744 0.541 0.715437530537 gnomAD-4.0.0 1.23993E-06 None None None None N None 0 3.33812E-05 None 0 0 None 0 0 0 0 0
G/D 28000 Ig-142 38 rs374151070 0.2208 -0.634 0.999 N 0.712 0.345 0.30921473904 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.64E-05 None 0 None 0 0 0
G/D 28000 Ig-142 38 rs374151070 0.2208 -0.634 0.999 N 0.712 0.345 0.30921473904 gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25002E-06 0 0
G/S 28000 Ig-142 38 rs1335831025 0.1374 -0.459 0.995 N 0.681 0.495 0.353336612579 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.69E-05 0
G/S 28000 Ig-142 38 rs1335831025 0.1374 -0.459 0.995 N 0.681 0.495 0.353336612579 gnomAD-4.0.0 9.58319E-06 None None None None N None 0 2.23994E-05 None 0 0 None 0 0 1.07961E-05 0 1.65744E-05
G/V 28000 Ig-142 38 rs374151070 0.5194 -0.232 0.995 D 0.733 0.436 None gnomAD-2.1.1 4.05E-06 None None None None N None 6.52E-05 0 None 0 0 None 0 None 0 0 0
G/V 28000 Ig-142 38 rs374151070 0.5194 -0.232 0.995 D 0.733 0.436 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/V 28000 Ig-142 38 rs374151070 0.5194 -0.232 0.995 D 0.733 0.436 None gnomAD-4.0.0 6.5722E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
G/S 28395 Ig-143 38 None 0.1524 None 0.997 N 0.695 0.487 0.323615622048 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/V 28395 Ig-143 38 rs2154159192 0.6081 None 0.995 D 0.733 0.455 0.657895878264 gnomAD-4.0.0 1.36844E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99454E-07 0 1.65662E-05
D/Y 28792 Ig-144 38 None 0.2784 None 1.0 N 0.623 0.494 0.620746667299 gnomAD-4.0.0 2.76378E-06 None None None None N None 0 0 None 0 0 None 0 5.27241E-04 9.05476E-07 0 0
G/D 29082 Ig-145 38 rs1176561473 0.147 -0.603 0.006 N 0.325 0.234 0.201204373187 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
G/D 29082 Ig-145 38 rs1176561473 0.147 -0.603 0.006 N 0.325 0.234 0.201204373187 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 29082 Ig-145 38 rs1176561473 0.147 -0.603 0.006 N 0.325 0.234 0.201204373187 gnomAD-4.0.0 2.47875E-06 None None None None N None 0 0 None 0 2.22896E-05 None 0 0 2.54271E-06 0 0
D/G 29478 Ig-146 35 None 0.0657 None None N 0.147 0.112 0.0762999501168 gnomAD-4.0.0 3.18293E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71618E-06 0 0
D/N 29478 Ig-146 35 rs1288820688 0.0747 0.084 None N 0.13 0.104 0.0920862733494 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 29478 Ig-146 35 rs1288820688 0.0747 0.084 None N 0.13 0.104 0.0920862733494 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/N 29478 Ig-146 35 rs1288820688 0.0747 0.084 None N 0.13 0.104 0.0920862733494 gnomAD-4.0.0 6.57402E-06 None None None None N None 0 6.5505E-05 None 0 0 None 0 0 0 0 0
D/Y 29478 Ig-146 35 rs1288820688 0.2252 0.002 0.741 N 0.401 0.278 0.407767136052 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
D/Y 29478 Ig-146 35 rs1288820688 0.2252 0.002 0.741 N 0.401 0.278 0.407767136052 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 29478 Ig-146 35 rs1288820688 0.2252 0.002 0.741 N 0.401 0.278 0.407767136052 gnomAD-4.0.0 6.57402E-06 None None None None N None 2.41464E-05 0 None 0 0 None 0 0 0 0 0
E/D 29877 Ig-147 36 rs767080000 0.0844 -0.028 0.004 N 0.181 0.083 0.166414681773 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.41849E-04 None 0 None 0 0 0
E/D 29877 Ig-147 36 rs767080000 0.0844 -0.028 0.004 N 0.181 0.083 0.166414681773 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
E/D 29877 Ig-147 36 rs767080000 0.0844 -0.028 0.004 N 0.181 0.083 0.166414681773 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 0 None 0 1.92604E-04 None 0 0 0 0 0
G/D 30169 Ig-148 38 rs775893072 0.128 -0.72 0.001 N 0.215 0.206 None gnomAD-2.1.1 3.41E-05 None None None None N None 0 0 None 0 0 None 0 None 0 7.45E-05 0
G/D 30169 Ig-148 38 rs775893072 0.128 -0.72 0.001 N 0.215 0.206 None gnomAD-4.0.0 9.03258E-06 None None None None N None 0 0 None 0 0 None 0 0 1.09214E-05 0 1.68623E-05
G/V 30169 Ig-148 38 None 0.2939 None 0.627 N 0.512 0.24 0.531825494424 gnomAD-4.0.0 6.94814E-07 None None None None N None 0 0 None 0 0 None 0 0 9.1012E-07 0 0
G/V 30564 Ig-149 33 rs1177595616 0.3327 -0.166 0.989 D 0.743 0.412 0.512998934155 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
G/V 30564 Ig-149 33 rs1177595616 0.3327 -0.166 0.989 D 0.743 0.412 0.512998934155 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
E/K 31253 Ig-151 36 rs767771567 0.331 0.261 0.998 N 0.539 0.351 0.215869574891 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/K 31253 Ig-151 36 rs767771567 0.331 0.261 0.998 N 0.539 0.351 0.215869574891 gnomAD-4.0.0 3.1823E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71579E-06 0 0
D/E 31653 Ig-152 33 rs546302731 0.0968 -0.176 0.067 N 0.303 0.094 0.195762928549 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.3071E-04 None 0 0 0
D/E 31653 Ig-152 33 rs546302731 0.0968 -0.176 0.067 N 0.303 0.094 0.195762928549 gnomAD-4.0.0 4.78951E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11557E-05 0
D/N 31653 Ig-152 33 rs1697134588 0.0789 None 0.988 N 0.662 0.263 0.195762928549 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 31653 Ig-152 33 rs1697134588 0.0789 None 0.988 N 0.662 0.263 0.195762928549 gnomAD-4.0.0 2.5623E-06 None None None None N None 0 0 None 0 2.42401E-05 None 0 0 2.39313E-06 0 0
G/S 32344 Ig-154 38 rs778602950 0.1386 -0.512 1.0 N 0.705 0.493 0.322510055762 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
G/S 32344 Ig-154 38 rs778602950 0.1386 -0.512 1.0 N 0.705 0.493 0.322510055762 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.22148E-04 0
G/S 32344 Ig-154 38 rs778602950 0.1386 -0.512 1.0 N 0.705 0.493 0.322510055762 gnomAD-4.0.0 1.48734E-05 None None None None N None 0 0 None 0 0 None 0 0 2.54289E-06 1.97641E-04 4.80323E-05
G/D 32742 Ig-155 35 rs201850303 0.3512 -0.748 1.0 N 0.653 0.388 None gnomAD-2.1.1 4.28E-05 None None None None N None 4.95868E-04 0 None 0 0 None 0 None 0 0 0
G/D 32742 Ig-155 35 rs201850303 0.3512 -0.748 1.0 N 0.653 0.388 None gnomAD-3.1.2 7.23E-05 None None None None N None 2.6547E-04 0 0 0 0 None 0 0 0 0 0
G/D 32742 Ig-155 35 rs201850303 0.3512 -0.748 1.0 N 0.653 0.388 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
G/D 32742 Ig-155 35 rs201850303 0.3512 -0.748 1.0 N 0.653 0.388 None gnomAD-4.0.0 1.85893E-05 None None None None N None 3.86502E-04 0 None 0 0 None 1.5623E-05 0 0 0 0
G/V 32742 Ig-155 35 None 0.6168 None 1.0 N 0.697 0.482 0.584612320503 gnomAD-4.0.0 6.84201E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99478E-07 0 0
Q/R 33234 Ig-157 32 None 0.0961 None 0.017 N 0.231 0.171 0.110078149338 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 34174 Ig-160 38 None 0.406 None 0.165 N 0.259 0.083 0.40318662893 gnomAD-4.0.0 1.59099E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85775E-06 0 0
V/I 34174 Ig-160 38 rs200430493 0.1017 -0.112 0.004 N 0.143 0.083 None gnomAD-2.1.1 8.92E-05 None None None None I None 4.13223E-04 5.65E-05 None 0 0 None 0 None 0 8.59E-05 2.80741E-04
V/I 34174 Ig-160 38 rs200430493 0.1017 -0.112 0.004 N 0.143 0.083 None gnomAD-3.1.2 1.77412E-04 None None None None I None 4.58384E-04 0 0 0 0 None 0 0 1.17592E-04 0 0
V/I 34174 Ig-160 38 rs200430493 0.1017 -0.112 0.004 N 0.143 0.083 None gnomAD-4.0.0 8.30329E-05 None None None None I None 3.20342E-04 1.00007E-04 None 0 2.22757E-05 None 0 1.64366E-04 8.05188E-05 2.19582E-05 8.00487E-05
G/A 34979 Ig-163 38 rs376634193 0.4578 -0.238 0.604 N 0.552 0.349 None gnomAD-2.1.1 8.91E-05 None None None None N None 1.23977E-04 5.65E-05 None 0 0 None 0 None 7.99E-05 1.40296E-04 0
G/A 34979 Ig-163 38 rs376634193 0.4578 -0.238 0.604 N 0.552 0.349 None gnomAD-3.1.2 1.44587E-04 None None None None N None 9.66E-05 0 0 0 0 None 1.88537E-04 0 2.35218E-04 0 0
G/A 34979 Ig-163 38 rs376634193 0.4578 -0.238 0.604 N 0.552 0.349 None gnomAD-4.0.0 1.30744E-04 None None None None N None 9.34505E-05 0 None 0 0 None 3.1248E-05 0 1.63577E-04 0 1.44083E-04
G/D 34979 Ig-163 38 rs376634193 0.5532 None 0.999 N 0.692 0.409 0.346315397577 gnomAD-4.0.0 4.10485E-06 None None None None N None 0 0 None 0 0 None 0 0 5.3964E-06 0 0
G/V 35166 Ig-164 38 rs1060500538 0.5762 -0.045 0.122 D 0.322 0.386 0.629718971361 gnomAD-2.1.1 4.01E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/V 35166 Ig-164 38 rs1060500538 0.5762 -0.045 0.122 D 0.322 0.386 0.629718971361 gnomAD-4.0.0 1.59087E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
G/S 35323 Ig-165 38 rs372749780 0.1682 -0.613 0.916 N 0.363 0.265 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/S 35323 Ig-165 38 rs372749780 0.1682 -0.613 0.916 N 0.363 0.265 None gnomAD-4.0.0 1.36827E-06 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 0 0 1.6564E-05
G/V 35457 Ig-166 38 None 0.5637 None 1.0 D 0.678 0.583 0.719642243069 gnomAD-4.0.0 6.93753E-07 None None None None I None 0 0 None 0 0 None 0 0 9.06937E-07 0 0
G/D 35642 Ig-167 36 rs1553480410 0.2755 None 1.0 N 0.594 0.59 0.396645960531 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 35739 Ig-168 38 rs771983508 0.1288 None 0.999 N 0.589 0.337 0.143124449307 gnomAD-4.0.0 1.61948E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.07333E-05
N/T 35739 Ig-168 38 rs771983508 0.3521 0.36 0.999 N 0.683 0.445 None gnomAD-2.1.1 8.26978E-04 None None None None N None 3.92616E-03 9E-05 None 4.15024E-04 0 None 0 None 2.34338E-03 7.571E-04 5.22284E-04
N/T 35739 Ig-168 38 rs771983508 0.3521 0.36 0.999 N 0.683 0.445 None gnomAD-4.0.0 7.93545E-05 None None None None N None 0 2.35018E-05 None 0 2.79345E-05 None 7.09383E-04 0 2.90789E-06 0 2.766E-04

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.