Structural position:

  • Domain Type: Ig
  • Aligned Position: 29
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/I 24 Ig-1 19 rs536235994 0.1442 0.134 1.0 N 0.793 0.477 0.582733548269 gnomAD-2.1.1 7.97E-06 None None None -0.166(TCAP) N None 0 0 None 0 0 None 3.27E-05 None 0 8.81E-06 0
T/I 24 Ig-1 19 rs536235994 0.1442 0.134 1.0 N 0.793 0.477 0.582733548269 gnomAD-3.1.2 6.57E-06 None None None -0.166(TCAP) N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 24 Ig-1 19 rs536235994 0.1442 0.134 1.0 N 0.793 0.477 0.582733548269 gnomAD-4.0.0 4.33741E-06 None None None -0.166(TCAP) N None 0 0 None 0 0 None 0 0 5.08487E-06 1.09844E-05 0
T/N 24 Ig-1 19 None 0.1564 -0.249 0.999 N 0.742 0.386 0.568214726415 gnomAD-2.1.1 1.59E-05 None None None -0.757(TCAP) N None 0 2.89E-05 None 0 5.45E-05 None 0 None 0 8.81E-06 1.63239E-04
T/N 24 Ig-1 19 None 0.1564 -0.249 0.999 N 0.742 0.386 0.568214726415 gnomAD-3.1.2 1.31E-05 None None None -0.757(TCAP) N None 0 0 0 0 0 None 0 0 1.47E-05 2.07125E-04 0
T/N 24 Ig-1 19 None 0.1564 -0.249 0.999 N 0.742 0.386 0.568214726415 gnomAD-4.0.0 1.05337E-05 None None None -0.757(TCAP) N None 0 1.66678E-05 None 0 0 None 0 1.64366E-04 1.01697E-05 2.19688E-05 1.60067E-05
T/P 24 Ig-1 19 rs758953324 0.4755 -0.384 0.999 D 0.791 0.448 0.599805095821 gnomAD-2.1.1 1.19E-05 None None None -0.15(TCAP) N None 0 0 None 0 0 None 6.54E-05 None 0 0 1.63292E-04
T/P 24 Ig-1 19 rs758953324 0.4755 -0.384 0.999 D 0.791 0.448 0.599805095821 gnomAD-4.0.0 6.15713E-06 None None None -0.15(TCAP) N None 0 0 None 0 0 None 0 0 0 1.04394E-04 0
T/S 24 Ig-1 19 rs536235994 0.1114 -0.632 0.993 N 0.597 0.25 0.389750110748 gnomAD-2.1.1 7.97E-06 None None None -0.641(TCAP) N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
T/S 24 Ig-1 19 rs536235994 0.1114 -0.632 0.993 N 0.597 0.25 0.389750110748 gnomAD-4.0.0 1.16301E-05 None None None -0.641(TCAP) N None 5.97372E-05 8.94494E-05 None 0 0 None 0 0 9.8926E-06 0 0
R/S 122 Ig-2 19 None 0.6245 None 0.193 N 0.632 0.365 0.337621943819 gnomAD-4.0.0 1.59266E-06 None None None -0.228(TCAP) N None 0 0 None 0 0 None 0 0 2.86121E-06 0 0
V/M 1100 Ig-4 19 None 0.1644 None 0.942 N 0.605 0.17 0.407767136052 gnomAD-4.0.0 1.59051E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02151E-05
T/I 1309 Ig-5 19 None 0.3522 None 1.0 N 0.784 0.494 0.430923071578 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79884E-06 0 0
T/N 1309 Ig-5 19 rs878985727 0.3787 None 1.0 N 0.711 0.359 0.44750879378 gnomAD-4.0.0 6.84202E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99418E-07 0 0
T/P 1309 Ig-5 19 None 0.7729 None 1.0 D 0.775 0.538 0.532503582573 gnomAD-4.0.0 1.32047E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44388E-05 0 0
R/K 1475 Ig-6 19 rs374591242 0.5915 0.081 0.997 N 0.511 0.401 None gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.82E-06 0
R/K 1475 Ig-6 19 rs374591242 0.5915 0.081 0.997 N 0.511 0.401 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/K 1475 Ig-6 19 rs374591242 0.5915 0.081 0.997 N 0.511 0.401 None gnomAD-4.0.0 5.12262E-06 None None None None I None 0 0 None 0 0 None 0 0 9.56791E-06 0 0
E/V 1574 Ig-7 19 None 0.2041 None 0.379 N 0.577 0.266 0.331619326243 gnomAD-4.0.0 1.59065E-06 None None None None N None 0 0 None 4.76644E-05 0 None 0 0 0 0 0
H/R 1721 Ig-8 19 rs1460034754 0.2357 -0.372 1.0 N 0.676 0.584 0.368554958709 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 0 0
H/R 1721 Ig-8 19 rs1460034754 0.2357 -0.372 1.0 N 0.676 0.584 0.368554958709 gnomAD-4.0.0 2.7364E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69789E-06 1.15931E-05 0
R/M 1859 Ig-9 19 rs777923620 0.8662 -0.536 1.0 D 0.677 0.507 0.476522311808 gnomAD-2.1.1 7.96E-06 None None None None N None 0 5.78E-05 None 0 0 None 0 None 0 0 0
R/M 1859 Ig-9 19 rs777923620 0.8662 -0.536 1.0 D 0.677 0.507 0.476522311808 gnomAD-4.0.0 1.59062E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
R/S 1859 Ig-9 19 rs551538420 0.9081 -0.943 0.978 N 0.644 0.424 0.346315397577 gnomAD-2.1.1 5.31E-05 None None None None N None 8.01E-05 0 None 9.65E-05 2.00562E-04 None 0 None 7.98E-05 4.65E-05 0
R/S 1859 Ig-9 19 rs551538420 0.9081 -0.943 0.978 N 0.644 0.424 0.346315397577 gnomAD-3.1.2 7.89E-05 None None None None N None 9.65E-05 0 0 0 3.84911E-04 None 0 0 8.82E-05 0 0
R/S 1859 Ig-9 19 rs551538420 0.9081 -0.943 0.978 N 0.644 0.424 0.346315397577 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/S 1859 Ig-9 19 rs551538420 0.9081 -0.943 0.978 N 0.644 0.424 0.346315397577 gnomAD-4.0.0 1.31342E-04 None None None None N None 7.99637E-05 0 None 3.37792E-05 1.11403E-04 None 9.37471E-05 0 1.61865E-04 1.09791E-05 3.1998E-05
H/R 2096 Ig-10 19 None 0.1487 None 0.031 N 0.323 0.244 0.212008924253 gnomAD-4.0.0 1.59062E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85659E-06 0 0
T/A 2193 Ig-11 20 rs147148170 0.2316 None 0.997 N 0.614 0.358 None gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
T/A 2193 Ig-11 20 rs147148170 0.2316 None 0.997 N 0.614 0.358 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 2193 Ig-11 20 rs147148170 0.2316 None 0.997 N 0.614 0.358 None gnomAD-4.0.0 6.57082E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
T/I 2193 Ig-11 20 None 0.4355 None 0.999 N 0.787 0.44 0.286848849266 gnomAD-4.0.0 1.36826E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79866E-06 0 0
T/N 2193 Ig-11 20 rs1574640739 0.4754 None 0.999 N 0.741 0.383 0.269111216191 gnomAD-4.0.0 2.05239E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69799E-06 0 0
E/D 2285 Ig-12 19 rs2091955390 0.1836 None 0.999 N 0.522 0.203 0.0986583533028 gnomAD-4.0.0 6.84193E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99368E-07 0 0
Q/H 2374 Ig-13 19 rs774105753 0.6904 -0.835 0.999 D 0.692 0.458 0.342631996419 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.63452E-04
Q/H 2374 Ig-13 19 rs774105753 0.6904 -0.835 0.999 D 0.692 0.458 0.342631996419 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
Q/H 2374 Ig-13 19 rs774105753 0.6904 -0.835 0.999 D 0.692 0.458 0.342631996419 gnomAD-4.0.0 7.68386E-06 None None None None N None 0 0 None 0 1.212E-04 None 0 0 0 0 2.84188E-05
V/A 2463 Ig-14 19 None 0.3905 None 0.334 N 0.585 0.174 0.46435556306 gnomAD-4.0.0 1.59072E-06 None None None None N None 0 0 None 0 0 None 0 2.4108E-04 0 0 0
V/E 2463 Ig-14 19 rs755393409 0.5781 -1.077 0.781 N 0.723 0.437 0.66941582999 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
V/E 2463 Ig-14 19 rs755393409 0.5781 -1.077 0.781 N 0.723 0.437 0.66941582999 gnomAD-4.0.0 1.59072E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85675E-06 0 0
V/M 2463 Ig-14 19 None 0.1936 None 0.638 N 0.666 0.149 0.30921473904 gnomAD-4.0.0 1.59075E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85678E-06 0 0
V/L 2551 Ig-15 19 None 0.1704 None 0.017 N 0.476 0.058 0.27855597813 gnomAD-4.0.0 6.8413E-07 None None None None N None 2.98757E-05 0 None 0 0 None 0 0 0 0 0
V/M 2551 Ig-15 19 None 0.1199 None 0.655 N 0.609 0.127 0.356072328145 gnomAD-4.0.0 6.8413E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65585E-05
V/E 2638 Ig-16 18 None 0.2254 None 0.125 N 0.444 0.207 0.32053947749 gnomAD-4.0.0 3.1818E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71481E-06 0 0
V/L 2638 Ig-16 18 rs878870422 0.149 None 0.247 N 0.503 0.097 0.276898752692 gnomAD-4.0.0 1.59093E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85752E-06 0 0
V/A 2725 Ig-17 19 rs146979556 0.1617 -1.359 0.656 D 0.52 0.524 None gnomAD-2.1.1 7.97E-06 None None None None N None 6.15E-05 0 None 0 5.45E-05 None 0 None 0 0 0
V/A 2725 Ig-17 19 rs146979556 0.1617 -1.359 0.656 D 0.52 0.524 None gnomAD-4.0.0 1.59074E-06 None None None None N None 0 0 None 0 2.77362E-05 None 0 0 0 0 0
V/I 2725 Ig-17 19 None 0.0723 None 0.014 D 0.351 0.184 0.43046518545 gnomAD-4.0.0 4.80129E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 3.9375E-06 0 0
T/A 2987 Ig-20 19 None 0.2063 None 0.999 N 0.6 0.37 0.203808441222 gnomAD-4.0.0 1.59072E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85654E-06 0 0
T/I 2987 Ig-20 19 rs1246906229 0.3446 -0.134 1.0 N 0.775 0.55 0.385578977469 gnomAD-2.1.1 3.98E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
T/I 2987 Ig-20 19 rs1246906229 0.3446 -0.134 1.0 N 0.775 0.55 0.385578977469 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 1.92456E-04 None 0 0 0 0 0
T/I 2987 Ig-20 19 rs1246906229 0.3446 -0.134 1.0 N 0.775 0.55 0.385578977469 gnomAD-4.0.0 3.04492E-06 None None None None N None 1.74776E-05 0 None 0 1.13302E-04 None 0 0 1.20492E-06 0 0
T/S 2987 Ig-20 19 rs1294263680 0.2348 -1.001 0.999 N 0.58 0.287 0.18274738541 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 4.62E-05 0 0
T/S 2987 Ig-20 19 rs1294263680 0.2348 -1.001 0.999 N 0.58 0.287 0.18274738541 gnomAD-4.0.0 4.77215E-06 None None None None N None 0 0 None 0 0 None 1.88225E-05 0 5.71308E-06 0 0
M/I 3076 Ig-21 19 rs144592053 0.267 -0.676 None N 0.197 0.086 0.132336055621 gnomAD-2.1.1 1.59E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.53E-05 0
M/I 3076 Ig-21 19 rs144592053 0.267 -0.676 None N 0.197 0.086 0.132336055621 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/I 3076 Ig-21 19 rs144592053 0.267 -0.676 None N 0.197 0.086 0.132336055621 gnomAD-4.0.0 5.57621E-06 None None None None N None 0 0 None 0 2.23005E-05 None 0 0 6.77955E-06 0 0
M/L 3076 Ig-21 19 rs766144077 0.1385 -0.7 None N 0.2 0.115 0.139678290688 gnomAD-2.1.1 7.97E-06 None None None None N None 1.23031E-04 0 None 0 0 None 0 None 0 0 0
M/L 3076 Ig-21 19 rs766144077 0.1385 -0.7 None N 0.2 0.115 0.139678290688 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
M/L 3076 Ig-21 19 rs766144077 0.1385 -0.7 None N 0.2 0.115 0.139678290688 gnomAD-4.0.0 1.85871E-06 None None None None N None 4.0031E-05 0 None 0 0 None 0 0 0 0 0
M/V 3076 Ig-21 19 rs766144077 0.0624 -1.033 None N 0.196 0.062 0.0611884634855 gnomAD-2.1.1 7.08E-06 None None None None N None 4E-05 0 None 0 0 None 0 None 0 7.76E-06 0
M/V 3076 Ig-21 19 rs766144077 0.0624 -1.033 None N 0.196 0.062 0.0611884634855 gnomAD-3.1.2 2.63E-05 None None None None N None 4.82E-05 6.54E-05 0 0 0 None 0 0 1.47E-05 0 0
M/V 3076 Ig-21 19 rs766144077 0.0624 -1.033 None N 0.196 0.062 0.0611884634855 gnomAD-4.0.0 6.81526E-06 None None None None N None 2.66873E-05 1.66667E-05 None 0 0 None 0 0 3.3898E-06 0 6.40143E-05
V/G 3165 Ig-22 19 None 0.6962 None 0.801 N 0.603 0.247 0.672219426627 gnomAD-4.0.0 1.20043E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31263E-06 0 0
V/I 3165 Ig-22 19 None 0.101 None 0.625 N 0.617 0.134 0.30212335484 gnomAD-4.0.0 6.8416E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65596E-05
V/L 3165 Ig-22 19 None 0.4066 None 0.625 N 0.633 0.156 0.246773566709 gnomAD-4.0.0 1.36832E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79874E-06 0 0
R/C 3257 Ig-23 19 rs374521620 0.468 -0.522 1.0 D 0.757 0.801 0.800107164582 gnomAD-2.1.1 3.59E-05 None None None None N None 0 1.44642E-04 None 0 0 None 0 None 0 2.65E-05 1.63613E-04
R/C 3257 Ig-23 19 rs374521620 0.468 -0.522 1.0 D 0.757 0.801 0.800107164582 gnomAD-4.0.0 6.15723E-06 None None None None N None 0 1.11822E-04 None 0 0 None 0 0 1.79865E-06 1.15942E-05 1.6564E-05
R/G 3257 Ig-23 19 None 0.8364 None 1.0 D 0.699 0.846 0.781155158808 gnomAD-4.0.0 6.84137E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99323E-07 0 0
R/H 3257 Ig-23 19 rs535876380 0.237 -1.214 1.0 N 0.746 0.672 0.446510307777 gnomAD-2.1.1 3.19E-05 None None None None N None 6.15E-05 8.68E-05 None 0 0 None 0 None 0 3.53E-05 0
R/H 3257 Ig-23 19 rs535876380 0.237 -1.214 1.0 N 0.746 0.672 0.446510307777 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 1.47E-05 2.07211E-04 0
R/H 3257 Ig-23 19 rs535876380 0.237 -1.214 1.0 N 0.746 0.672 0.446510307777 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
R/H 3257 Ig-23 19 rs535876380 0.237 -1.214 1.0 N 0.746 0.672 0.446510307777 gnomAD-4.0.0 7.06306E-05 None None None None N None 1.3328E-05 6.66511E-05 None 0 0 None 0 0 8.98313E-05 1.09801E-05 3.20061E-05
R/S 3257 Ig-23 19 rs374521620 0.8467 -0.69 1.0 N 0.729 0.782 None gnomAD-2.1.1 1.99E-05 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 2.65E-05 0
R/S 3257 Ig-23 19 rs374521620 0.8467 -0.69 1.0 N 0.729 0.782 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.30941E-04 0 0 0 None 0 0 1.47E-05 0 0
R/S 3257 Ig-23 19 rs374521620 0.8467 -0.69 1.0 N 0.729 0.782 None gnomAD-4.0.0 1.30125E-05 None None None None N None 0 1.0002E-04 None 0 0 None 0 0 1.27121E-05 0 0
R/C 3363 Ig-24 19 rs764030230 0.1042 -0.128 0.002 D 0.503 0.389 0.514184785564 gnomAD-2.1.1 2.83E-05 None None None None N None 0 1.41107E-04 None 0 0 None 0 None 0 2.32E-05 0
R/C 3363 Ig-24 19 rs764030230 0.1042 -0.128 0.002 D 0.503 0.389 0.514184785564 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 4.41E-05 0 0
R/C 3363 Ig-24 19 rs764030230 0.1042 -0.128 0.002 D 0.503 0.389 0.514184785564 gnomAD-4.0.0 1.30118E-05 None None None None N None 0 1.16671E-04 None 0 0 None 0 0 1.10172E-05 0 1.60046E-05
R/G 3363 Ig-24 19 None 0.2171 None 0.13 D 0.543 0.452 0.543165868402 gnomAD-4.0.0 6.84086E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
R/H 3363 Ig-24 19 rs148169214 0.0683 -1.11 None N 0.281 0.191 None gnomAD-2.1.1 2.33473E-04 None None None None N None 2.04278E-03 2.82E-05 None 0 2.50954E-04 None 3.27E-05 None 0 5.42E-05 1.38504E-04
R/H 3363 Ig-24 19 rs148169214 0.0683 -1.11 None N 0.281 0.191 None gnomAD-3.1.2 7.42737E-04 None None None None N None 2.6063E-03 0 0 0 1.92678E-04 None 0 0 4.41E-05 0 4.77555E-04
R/H 3363 Ig-24 19 rs148169214 0.0683 -1.11 None N 0.281 0.191 None 1000 genomes 7.98722E-04 None None None None N None 3E-03 0 None None 0 0 None None None 0 None
R/H 3363 Ig-24 19 rs148169214 0.0683 -1.11 None N 0.281 0.191 None gnomAD-4.0.0 1.52411E-04 None None None None N None 2.47881E-03 1.66628E-05 None 0 4.45772E-05 None 0 1.64962E-04 3.64423E-05 3.29381E-05 1.5998E-04
Q/E 3678 Ig-26 19 rs552438291 0.1083 0.469 None None None 0.051 None gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
Q/E 3678 Ig-26 19 rs552438291 0.1083 0.469 None None None 0.051 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
Q/E 3678 Ig-26 19 rs552438291 0.1083 0.469 None None None 0.051 None gnomAD-4.0.0 1.28111E-05 None None None None N None 0 0 None 0 0 None 0 0 2.39284E-05 0 0
Q/R 3678 Ig-26 19 None 0.1316 None None None None 0.08 None gnomAD-4.0.0 6.84225E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
T/I 3838 Ig-27 19 None 0.145 None 0.065 N 0.513 0.076 None gnomAD-4.0.0 1.36853E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79901E-06 0 0
T/K 3838 Ig-27 19 rs752583542 0.0969 -0.114 None N 0.209 0.096 None gnomAD-4.0.0 1.36854E-06 None None None None N None 2.98793E-05 0 None 0 0 None 0 0 0 0 1.65706E-05
I/T 3956 Ig-28 19 rs1156715113 0.231 None 0.012 N 0.377 0.056 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 3956 Ig-28 19 rs1156715113 0.231 None 0.012 N 0.377 0.056 None gnomAD-4.0.0 6.81622E-06 None None None None I None 0 0 None 0 0 None 0 0 9.32336E-06 0 0
I/V 3956 Ig-28 19 rs2154318798 0.0665 None None N 0.195 0.041 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
I/V 3956 Ig-28 19 rs2154318798 0.0665 None None N 0.195 0.041 None gnomAD-4.0.0 6.56573E-06 None None None None I None 0 0 None 0 1.93424E-04 None 0 0 0 0 0
K/E 4718 Ig-30 19 rs757119133 0.3408 0.42 0.946 N 0.617 0.251 0.191931220699 gnomAD-2.1.1 2.15E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.69E-05 0
K/E 4718 Ig-30 19 rs757119133 0.3408 0.42 0.946 N 0.617 0.251 0.191931220699 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
K/E 4718 Ig-30 19 rs757119133 0.3408 0.42 0.946 N 0.617 0.251 0.191931220699 gnomAD-4.0.0 5.14421E-05 None None None None N None 0 0 None 0 0 None 0 0 6.95084E-05 0 1.6019E-05
K/I 4718 Ig-30 19 rs753558755 0.4754 0.745 0.811 N 0.578 0.219 0.300110245524 gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 3.92773E-04 None 0 None 0 0 0
K/I 4718 Ig-30 19 rs753558755 0.4754 0.745 0.811 N 0.578 0.219 0.300110245524 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
K/I 4718 Ig-30 19 rs753558755 0.4754 0.745 0.811 N 0.578 0.219 0.300110245524 gnomAD-4.0.0 5.57814E-06 None None None None N None 0 0 None 0 2.00974E-04 None 0 0 0 0 0
K/R 4718 Ig-30 19 rs753558755 0.0871 None 0.982 N 0.615 0.174 0.231231049324 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 1.73551E-04 8.99539E-07 0 0
K/Q 4813 Ig-31 19 None 0.1526 None 0.136 N 0.365 0.139 0.12205267543 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 4813 Ig-31 19 None 0.0845 None 0.012 N 0.336 0.075 0.173771789658 gnomAD-4.0.0 1.5934E-06 None None None None N None 0 0 None 0 0 None 1.88352E-05 0 0 0 0
H/L 4906 Ig-32 19 rs2081328374 0.073 None 0.117 N 0.545 0.142 0.148003135375 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
H/L 4906 Ig-32 19 rs2081328374 0.073 None 0.117 N 0.545 0.142 0.148003135375 gnomAD-4.0.0 6.57013E-06 None None None None N None 0 6.54793E-05 None 0 0 None 0 0 0 0 0
H/Q 4906 Ig-32 19 rs192727802 0.1011 -0.062 0.062 N 0.468 0.05 0.152612264143 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/C 5000 Ig-33 20 rs369933152 0.1597 -0.201 0.999 N 0.613 0.392 None gnomAD-2.1.1 1.13302E-04 None None None None N None 1.17391E-03 2.89E-05 None 0 0 None 0 None 0 1.61E-05 0
R/C 5000 Ig-33 20 rs369933152 0.1597 -0.201 0.999 N 0.613 0.392 None gnomAD-3.1.2 3.15424E-04 None None None None N None 1.0376E-03 6.55E-05 0 0 0 None 0 0 2.94E-05 0 9.5511E-04
R/C 5000 Ig-33 20 rs369933152 0.1597 -0.201 0.999 N 0.613 0.392 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/C 5000 Ig-33 20 rs369933152 0.1597 -0.201 0.999 N 0.613 0.392 None gnomAD-4.0.0 7.13735E-05 None None None None N None 9.59795E-04 6.71727E-05 None 0 6.71892E-05 None 0 1.6518E-04 2.12146E-05 2.20138E-05 1.28263E-04
R/G 5000 Ig-33 20 None 0.3752 None 0.911 D 0.565 0.446 0.468003879618 gnomAD-4.0.0 6.85424E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16241E-05 0
R/H 5000 Ig-33 20 rs377062348 0.0774 -1.159 0.066 N 0.348 0.177 None gnomAD-2.1.1 2.19E-05 None None None None N None 0 2.89E-05 None 0 0 None 3.31E-05 None 0 3.22E-05 0
R/H 5000 Ig-33 20 rs377062348 0.0774 -1.159 0.066 N 0.348 0.177 None gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 2.61917E-04 0 0 0 None 0 0 4.41E-05 0 0
R/H 5000 Ig-33 20 rs377062348 0.0774 -1.159 0.066 N 0.348 0.177 None gnomAD-4.0.0 2.42061E-05 None None None None N None 2.67073E-05 8.39913E-05 None 0 4.47688E-05 None 1.56597E-05 0 1.44255E-05 1.21063E-04 1.6038E-05
R/P 5000 Ig-33 20 None 0.9072 None 0.986 D 0.617 0.422 0.317667799068 gnomAD-4.0.0 1.37079E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80109E-06 0 0
L/I 5093 Ig-34 19 None 0.0657 None 0.001 N 0.242 0.1 0.26169431596 gnomAD-4.0.0 6.87004E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02341E-07 0 0
L/V 5093 Ig-34 19 rs764663290 0.0632 -0.815 None N 0.281 0.108 0.263140351381 gnomAD-2.1.1 2.47E-05 None None None None N None 0 0 None 0 0 None 1.71233E-04 None 0 9.06E-06 0
L/V 5093 Ig-34 19 rs764663290 0.0632 -0.815 None N 0.281 0.108 0.263140351381 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/V 5093 Ig-34 19 rs764663290 0.0632 -0.815 None N 0.281 0.108 0.263140351381 gnomAD-4.0.0 1.43052E-05 None None None None N None 0 0 None 0 0 None 0 0 7.6514E-06 1.55466E-04 0
T/S 5186 Ig-35 19 None 0.1035 None 0.016 N 0.357 0.113 0.101711395817 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/A 5279 Ig-36 19 rs559795262 0.0857 -0.73 0.863 N 0.604 0.102 0.159798565429 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 1.02512E-04 None 0 None 0 0 0
T/A 5279 Ig-36 19 rs559795262 0.0857 -0.73 0.863 N 0.604 0.102 0.159798565429 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.85802E-04 None 0 0 0 0 0
T/A 5279 Ig-36 19 rs559795262 0.0857 -0.73 0.863 N 0.604 0.102 0.159798565429 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
T/A 5279 Ig-36 19 rs559795262 0.0857 -0.73 0.863 N 0.604 0.102 0.159798565429 gnomAD-4.0.0 3.04438E-06 None None None None N None 0 0 None 0 2.27221E-04 None 0 0 0 0 3.39997E-05
R/S 5375 Ig-37 19 None 0.2801 None 0.009 N 0.381 0.219 0.112648838833 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
C/S 5468 Ig-38 19 rs1294705818 0.1005 None None N 0.249 0.195 0.345859378078 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.64E-05 None 0 None 0 0 0
C/S 5468 Ig-38 19 rs1294705818 0.1005 None None N 0.249 0.195 0.345859378078 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.85505E-04 None 0 0 0 0 0
C/S 5468 Ig-38 19 rs1294705818 0.1005 None None N 0.249 0.195 0.345859378078 gnomAD-4.0.0 6.42125E-06 None None None None N None 0 0 None 0 1.21696E-04 None 0 0 0 0 0
C/W 5468 Ig-38 19 rs944088736 0.1871 -0.511 0.612 N 0.499 0.187 0.514472708086 gnomAD-2.1.1 4.06E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 0
C/W 5468 Ig-38 19 rs944088736 0.1871 -0.511 0.612 N 0.499 0.187 0.514472708086 gnomAD-4.0.0 1.596E-06 None None None None N None 5.67151E-05 0 None 0 0 None 0 0 0 0 0
M/I 5655 Ig-40 19 rs750859083 0.1882 0.02 None N 0.238 0.191 0.178374595973 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
M/I 5655 Ig-40 19 rs750859083 0.1882 0.02 None N 0.238 0.191 0.178374595973 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
M/R 5655 Ig-40 19 None 0.1852 None 0.014 N 0.474 0.215 0.290590437066 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02462E-05
M/V 5655 Ig-40 19 rs2080601989 0.0799 None None N 0.221 0.128 0.170165803431 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 5655 Ig-40 19 rs2080601989 0.0799 None None N 0.221 0.128 0.170165803431 gnomAD-4.0.0 2.56251E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78675E-06 0 0
A/D 5748 Ig-41 19 rs772161489 0.4439 -0.489 0.801 N 0.517 0.167 0.413503789086 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
A/D 5748 Ig-41 19 rs772161489 0.4439 -0.489 0.801 N 0.517 0.167 0.413503789086 gnomAD-4.0.0 3.18514E-06 None None None None N None 0 2.28959E-05 None 0 0 None 0 0 2.86022E-06 0 0
T/A 5841 Ig-42 19 rs1347598272 0.0963 -0.379 0.981 N 0.557 0.245 0.16115917748 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 0
T/A 5841 Ig-42 19 rs1347598272 0.0963 -0.379 0.981 N 0.557 0.245 0.16115917748 gnomAD-4.0.0 6.36576E-06 None None None None N None 0 9.14662E-05 None 0 0 None 0 0 0 0 0
T/I 5841 Ig-42 19 None 0.164 None 0.999 N 0.778 0.377 0.359151904892 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/S 5841 Ig-42 19 rs1347598272 0.1392 None 0.905 N 0.355 0.137 0.146414634003 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93349E-04 None 0 0 0 0 0
T/S 5841 Ig-42 19 rs1347598272 0.1392 None 0.905 N 0.355 0.137 0.146414634003 gnomAD-4.0.0 6.57281E-06 None None None None N None 0 0 None 0 1.93349E-04 None 0 0 0 0 0
Q/E 6030 Ig-44 19 None 0.0885 None 0.174 N 0.577 0.139 0.0846915920261 gnomAD-4.0.0 1.59729E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86743E-06 0 0
Q/R 6030 Ig-44 19 rs1560784359 0.0971 None 0.505 N 0.595 0.146 0.0762999501168 gnomAD-4.0.0 6.16735E-06 None None None None N None 0 0 None 0 0 None 0 0 7.20277E-06 0 1.65848E-05
T/A 6124 Ig-45 20 None 0.0699 None 0.001 D 0.274 0.204 0.253205268125 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/I 6124 Ig-45 20 rs1280788914 0.0954 0.02 0.101 N 0.5 0.299 0.394230963961 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 6124 Ig-45 20 rs1280788914 0.0954 0.02 0.101 N 0.5 0.299 0.394230963961 gnomAD-4.0.0 1.3687E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79909E-06 0 0
T/K 6124 Ig-45 20 rs1280788914 0.1432 -0.318 0.351 N 0.479 0.348 0.429435026966 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
T/K 6124 Ig-45 20 rs1280788914 0.1432 -0.318 0.351 N 0.479 0.348 0.429435026966 gnomAD-4.0.0 6.84348E-07 None None None None N None 0 2.23874E-05 None 0 0 None 0 0 0 0 0
E/G 6217 Ig-46 19 None 0.1214 None 0.014 N 0.421 0.208 0.190952846119 gnomAD-4.0.0 1.36862E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99578E-07 1.15942E-05 0
T/N 6403 Ig-48 19 rs764889206 0.1736 -0.429 0.92 N 0.517 0.261 0.270447802918 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
T/N 6403 Ig-48 19 rs764889206 0.1736 -0.429 0.92 N 0.517 0.261 0.270447802918 gnomAD-4.0.0 1.43738E-05 None None None None N None 0 0 None 0 0 None 3.76705E-05 0 2.01161E-05 0 0
T/S 6403 Ig-48 19 rs1466667894 0.1841 -0.729 0.159 N 0.311 0.093 0.154104182512 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
T/S 6403 Ig-48 19 rs1466667894 0.1841 -0.729 0.159 N 0.311 0.093 0.154104182512 gnomAD-4.0.0 1.59729E-06 None None None None N None 0 2.28969E-05 None 0 0 None 0 0 0 0 0
H/L 6499 Ig-49 19 rs375173049 0.0802 1.104 0.055 N 0.516 0.212 None gnomAD-2.1.1 3.25E-05 None None None None N None 3.74251E-04 0 None 0 0 None 0 None 0 0 0
H/L 6499 Ig-49 19 rs375173049 0.0802 1.104 0.055 N 0.516 0.212 None gnomAD-3.1.2 1.18312E-04 None None None None N None 4.34363E-04 0 0 0 0 None 0 0 0 0 0
H/L 6499 Ig-49 19 rs375173049 0.0802 1.104 0.055 N 0.516 0.212 None gnomAD-4.0.0 1.79944E-05 None None None None N None 3.87545E-04 0 None 0 0 None 0 0 0 0 0
R/G 6686 Ig-51 20 None 0.2519 None 0.981 N 0.547 0.32 0.322510055762 gnomAD-4.0.0 6.84814E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99985E-07 0 0
R/Q 6686 Ig-51 20 rs202022304 0.0841 -0.249 0.624 N 0.449 0.236 None gnomAD-2.1.1 2.51E-05 None None None None N None 8.28E-05 0 None 0 0 None 0 None 0 3.92E-05 0
R/Q 6686 Ig-51 20 rs202022304 0.0841 -0.249 0.624 N 0.449 0.236 None gnomAD-3.1.2 3.95E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/Q 6686 Ig-51 20 rs202022304 0.0841 -0.249 0.624 N 0.449 0.236 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/Q 6686 Ig-51 20 rs202022304 0.0841 -0.249 0.624 N 0.449 0.236 None gnomAD-4.0.0 1.36438E-05 None None None None N None 8.00384E-05 0 None 0 0 None 1.56436E-05 0 1.10251E-05 0 3.204E-05
S/C 6779 Ig-52 19 rs149470241 0.1201 -0.163 0.99 N 0.539 0.501 None gnomAD-2.1.1 5.7142E-04 None None None None N None 3.36814E-04 1.19603E-04 None 0 0 None 0 None 0 1.12904E-03 2.91545E-04
S/C 6779 Ig-52 19 rs149470241 0.1201 -0.163 0.99 N 0.539 0.501 None gnomAD-3.1.2 5.9811E-04 None None None None N None 3.61847E-04 1.96721E-04 0 0 0 None 0 0 1.07331E-03 0 0
S/C 6779 Ig-52 19 rs149470241 0.1201 -0.163 0.99 N 0.539 0.501 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
S/C 6779 Ig-52 19 rs149470241 0.1201 -0.163 0.99 N 0.539 0.501 None gnomAD-4.0.0 1.53006E-03 None None None None N None 3.21569E-04 1.01564E-04 None 0 0 None 4.70072E-05 0 2.01995E-03 1.12065E-05 7.73171E-04
E/K 6872 Ig-53 19 rs376378443 0.1166 0.114 0.134 N 0.288 0.194 None gnomAD-2.1.1 1.8E-05 None None None None N None 2.07142E-04 0 None 0 0 None 0 None 0 0 0
E/K 6872 Ig-53 19 rs376378443 0.1166 0.114 0.134 N 0.288 0.194 None gnomAD-3.1.2 5.92E-05 None None None None N None 2.17192E-04 0 0 0 0 None 0 0 0 0 0
E/K 6872 Ig-53 19 rs376378443 0.1166 0.114 0.134 N 0.288 0.194 None gnomAD-4.0.0 8.06738E-06 None None None None N None 1.60466E-04 0 None 0 0 None 0 0 0 0 1.60395E-05
T/A 6966 Ig-54 19 rs764077044 0.0925 -0.59 None N 0.362 0.033 0.0401082797425 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 1.665E-04
T/A 6966 Ig-54 19 rs764077044 0.0925 -0.59 None N 0.362 0.033 0.0401082797425 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/A 6966 Ig-54 19 rs764077044 0.0925 -0.59 None N 0.362 0.033 0.0401082797425 gnomAD-4.0.0 4.34138E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08948E-06 1.099E-05 0
T/S 6966 Ig-54 19 rs764077044 0.1145 None 0.001 N 0.472 0.027 0.0716867268079 gnomAD-4.0.0 6.84777E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0015E-07 0 0
I/L 7062 Ig-55 19 None 0.0768 None 0.001 N 0.255 0.068 0.0884992946249 gnomAD-4.0.0 6.84382E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99611E-07 0 0
I/T 7062 Ig-55 19 None 0.1172 None 0.351 N 0.455 0.198 0.376393476264 gnomAD-4.0.0 1.36878E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79923E-06 0 0
I/V 7062 Ig-55 19 rs766548354 0.0667 -0.62 0.001 N 0.24 0.042 0.128392430309 gnomAD-4.0.0 1.36876E-06 None None None None N None 0 0 None 0 2.52232E-05 None 0 0 8.99611E-07 0 0
T/A 7155 Ig-56 19 None 0.1137 None 0.139 N 0.391 0.202 0.104622674875 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 7248 Ig-57 19 None 0.1951 None 0.007 N 0.353 0.183 0.334161072951 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/Y 7341 Ig-58 19 rs1474346427 0.1809 -0.415 0.975 N 0.543 0.259 0.467501455318 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
S/Y 7341 Ig-58 19 rs1474346427 0.1809 -0.415 0.975 N 0.543 0.259 0.467501455318 gnomAD-4.0.0 1.59317E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86097E-06 0 0
T/I 7437 Ig-59 19 rs1163896021 0.116 0.157 0.642 N 0.451 0.183 0.447213685739 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/I 7437 Ig-59 19 rs1163896021 0.116 0.157 0.642 N 0.451 0.183 0.447213685739 gnomAD-4.0.0 6.84371E-07 None None None None N None 0 2.23644E-05 None 0 0 None 0 0 0 0 0
T/K 7437 Ig-59 19 None 0.2067 None 0.001 N 0.259 0.269 0.351830644314 gnomAD-4.0.0 6.84371E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65717E-05
D/N 7533 Ig-60 19 rs371762361 0.1293 -0.522 0.324 N 0.518 0.179 None gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
D/N 7533 Ig-60 19 rs371762361 0.1293 -0.522 0.324 N 0.518 0.179 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 7533 Ig-60 19 rs371762361 0.1293 -0.522 0.324 N 0.518 0.179 None gnomAD-4.0.0 6.57151E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47016E-05 0 0
Q/K 7627 Ig-61 20 None 0.0789 None None N 0.307 0.221 0.112648838833 gnomAD-4.0.0 1.36986E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.31785E-05
I/V 7720 Ig-62 19 rs757989250 0.0655 -0.882 None N 0.316 0.058 0.152612264143 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 6.55E-05 None 0 0 0
I/V 7720 Ig-62 19 rs757989250 0.0655 -0.882 None N 0.316 0.058 0.152612264143 gnomAD-4.0.0 4.77815E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86763E-05 3.02792E-05
E/Q 7813 Ig-63 19 None 0.1283 None 0.001 N 0.323 0.146 0.0551355673512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 8096 Ig-66 19 rs370271716 0.1453 None None N 0.389 0.068 0.134241683229 gnomAD-4.0.0 6.84548E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99713E-07 0 0
T/A 8282 Ig-68 19 rs2077783131 0.0839 None 0.002 D 0.302 0.234 0.202949470691 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
T/I 8282 Ig-68 19 None 0.0992 None 0.685 N 0.507 0.232 0.452264262256 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 8378 Ig-69 19 None 0.1007 None 0.473 N 0.395 0.25 0.417334834585 gnomAD-4.0.0 1.36897E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99661E-07 1.16069E-05 0
T/S 8474 Ig-70 19 None 0.0631 None None N 0.237 0.062 0.0401082797425 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85959E-06 0 0
R/M 8568 Ig-71 20 None 0.2063 None 0.97 N 0.62 0.217 0.254244900254 gnomAD-4.0.0 1.61428E-06 None None None None N None 0 0 None 0 2.79861E-05 None 0 0 0 0 0
R/S 8568 Ig-71 20 None 0.259 None 0.642 N 0.547 0.158 0.117506650769 gnomAD-4.0.0 6.88015E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.66478E-05
H/Y 8661 Ig-72 19 None 0.0926 None 0.846 N 0.419 0.138 0.209622950755 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
Q/H 8754 Ig-73 19 rs764746720 0.1363 -0.231 0.239 N 0.401 0.122 0.0551355673512 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
Q/H 8754 Ig-73 19 rs764746720 0.1363 -0.231 0.239 N 0.401 0.122 0.0551355673512 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
Q/H 8754 Ig-73 19 rs764746720 0.1363 -0.231 0.239 N 0.401 0.122 0.0551355673512 gnomAD-4.0.0 5.57899E-06 None None None None N None 0 0 None 0 0 None 0 0 0 9.88859E-05 0
V/A 8944 Ig-75 19 rs1577869516 0.1354 None 0.201 N 0.436 0.136 0.459463830659 gnomAD-4.0.0 1.63684E-06 None None None None N None 0 0 None 0 2.82103E-05 None 0 0 0 0 0
V/I 8944 Ig-75 19 rs72648993 0.0723 -0.293 0.004 N 0.264 0.047 None gnomAD-2.1.1 1.84E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.18E-05 0
V/I 8944 Ig-75 19 rs72648993 0.0723 -0.293 0.004 N 0.264 0.047 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/I 8944 Ig-75 19 rs72648993 0.0723 -0.293 0.004 N 0.264 0.047 None gnomAD-4.0.0 1.31569E-05 None None None None N None 2.67759E-05 0 None 0 0 None 0 0 1.53817E-05 0 1.61582E-05
I/N 9130 Ig-77 19 rs1316381392 0.383 -0.742 0.784 N 0.547 0.157 0.584426982296 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/N 9130 Ig-77 19 rs1316381392 0.383 -0.742 0.784 N 0.547 0.157 0.584426982296 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
I/N 9130 Ig-77 19 rs1316381392 0.383 -0.742 0.784 N 0.547 0.157 0.584426982296 gnomAD-4.0.0 2.72701E-05 None None None None N None 0 0 None 0 0 None 0 0 3.64489E-05 0 1.60174E-05
S/F 9223 Ig-78 19 rs778581432 0.1655 -0.756 0.976 N 0.594 0.229 0.41518383557 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/F 9223 Ig-78 19 rs778581432 0.1655 -0.756 0.976 N 0.594 0.229 0.41518383557 gnomAD-4.0.0 6.84208E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.04358E-04 1.65645E-05
S/P 9223 Ig-78 19 rs201253546 0.8773 -0.01 0.996 N 0.601 0.307 None gnomAD-2.1.1 8.93E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.95471E-04 0
S/P 9223 Ig-78 19 rs201253546 0.8773 -0.01 0.996 N 0.601 0.307 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
S/P 9223 Ig-78 19 rs201253546 0.8773 -0.01 0.996 N 0.601 0.307 None gnomAD-4.0.0 4.2758E-05 None None None None N None 0 0 None 0 0 None 0 0 5.59417E-05 0 4.80292E-05
S/Y 9223 Ig-78 19 None 0.185 None 0.996 N 0.585 0.247 0.42264334713 gnomAD-4.0.0 6.84208E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
V/I 9319 Ig-79 19 None 0.0762 None None None 0.216 0.072 0.296679040009 gnomAD-4.0.0 1.59204E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43542E-05 0
D/E 9415 Ig-80 19 rs2076551495 0.1472 None 0.003 None 0.248 0.129 0.130388298395 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/E 9415 Ig-80 19 rs2076551495 0.1472 None 0.003 None 0.248 0.129 0.130388298395 gnomAD-4.0.0 1.59109E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85799E-06 0 0
K/E 9512 Ig-81 20 None 0.2223 None 0.201 None 0.603 0.144 0.171388866994 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 9716 Ig-83 19 rs368642940 0.1788 0.247 1.0 None 0.742 0.315 0.321672782286 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 6.76E-05 None 0 0 0
T/I 9716 Ig-83 19 rs368642940 0.1788 0.247 1.0 None 0.742 0.315 0.321672782286 gnomAD-4.0.0 1.16751E-05 None None None None N None 0 0 None 0 0 None 0 0 8.11633E-06 5.8782E-05 4.99085E-05
T/N 10007 Ig-85 19 rs1168557032 0.24 None 0.81 None 0.531 0.156 0.263612267334 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 7.32654E-05
I/F 13705 Ig-87 22 None 0.5997 None 0.934 N 0.557 0.189 0.340032825777 gnomAD-4.0.0 6.84351E-07 None None None None N None 2.98864E-05 0 None 0 0 None 0 0 0 0 0
I/T 13705 Ig-87 22 None 0.581 None 0.051 N 0.403 0.201 0.426551566703 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 13705 Ig-87 22 rs769704113 0.0954 -1.401 0.005 N 0.29 0.045 0.319114376414 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.12082E-04 None 3.27E-05 None 0 0 0
I/V 13705 Ig-87 22 rs769704113 0.0954 -1.401 0.005 N 0.29 0.045 0.319114376414 gnomAD-4.0.0 4.79046E-06 None None None None N None 0 0 None 0 5.05076E-05 None 0 0 2.6988E-06 2.31889E-05 0
I/M 13892 Ig-89 17 None 0.1743 None 0.087 N 0.373 0.012 0.350088858571 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
R/L 14072 Ig-91 19 rs747161377 0.4937 0.366 0.858 N 0.508 0.296 0.221019684889 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/L 14072 Ig-91 19 rs747161377 0.4937 0.366 0.858 N 0.508 0.296 0.221019684889 gnomAD-4.0.0 1.02659E-05 None None None None N None 0 0 None 0 5.04439E-05 None 0 0 1.16955E-05 0 0
R/P 14072 Ig-91 19 rs747161377 0.9783 None 0.998 N 0.587 0.321 0.364342057095 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/P 14072 Ig-91 19 rs747161377 0.9783 None 0.998 N 0.587 0.321 0.364342057095 gnomAD-4.0.0 6.84396E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99654E-07 0 0
R/Q 14072 Ig-91 19 None 0.2178 -0.106 0.985 N 0.578 0.254 0.188950314367 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 1.11707E-04 None 6.54E-05 None 0 8.91E-06 0
R/Q 14072 Ig-91 19 None 0.2178 -0.106 0.985 N 0.578 0.254 0.188950314367 gnomAD-4.0.0 1.30035E-05 None None None None N None 0 0 None 0 2.5222E-05 None 1.8728E-05 0 7.19723E-06 9.27924E-05 1.65717E-05
T/I 14160 Ig-92 19 None 0.0965 None 0.001 N 0.271 0.114 0.213573922156 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 14426 Ig-95 19 rs557077441 0.2318 0.171 0.822 N 0.556 0.424 0.305730143919 gnomAD-2.1.1 2.42E-05 None None None None N None 0 0 None 0 0 None 1.96155E-04 None 0 0 0
K/E 14426 Ig-95 19 rs557077441 0.2318 0.171 0.822 N 0.556 0.424 0.305730143919 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
K/E 14426 Ig-95 19 rs557077441 0.2318 0.171 0.822 N 0.556 0.424 0.305730143919 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/E 14426 Ig-95 19 rs557077441 0.2318 0.171 0.822 N 0.556 0.424 0.305730143919 gnomAD-4.0.0 5.57856E-06 None None None None N None 0 0 None 0 0 None 0 0 0 7.68741E-05 3.20205E-05
V/A 14515 Ig-96 19 None 0.2028 None 0.625 D 0.556 0.396 0.716962004524 gnomAD-4.0.0 1.61086E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.46289E-05 0
V/L 14515 Ig-96 19 None 0.2042 None 0.625 D 0.602 0.401 0.611273083002 gnomAD-4.0.0 8.40227E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18753E-06 0 0
R/C 14693 Ig-98 19 rs200445568 0.1 -0.114 1.0 N 0.613 0.369 None gnomAD-2.1.1 2.32251E-04 None None None None N None 2.35693E-03 1.41483E-04 None 0 0 None 3.27E-05 None 0 1.56E-05 0
R/C 14693 Ig-98 19 rs200445568 0.1 -0.114 1.0 N 0.613 0.369 None gnomAD-3.1.2 7.56479E-04 None None None None N None 2.51123E-03 4.59559E-04 0 0 0 None 0 0 1.47E-05 0 1.43678E-03
R/C 14693 Ig-98 19 rs200445568 0.1 -0.114 1.0 N 0.613 0.369 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
R/C 14693 Ig-98 19 rs200445568 0.1 -0.114 1.0 N 0.613 0.369 None gnomAD-4.0.0 1.50009E-04 None None None None N None 2.50733E-03 2.33505E-04 None 0 0 None 0 1.65235E-04 1.27171E-05 4.393E-05 3.20277E-04
R/H 14693 Ig-98 19 rs746380621 0.0576 -0.659 1.0 N 0.644 0.291 0.146414634003 gnomAD-2.1.1 6.79E-05 None None None None N None 0 2.83E-05 None 9.67E-05 6.71141E-04 None 6.54E-05 None 0 7.81E-06 1.40568E-04
R/H 14693 Ig-98 19 rs746380621 0.0576 -0.659 1.0 N 0.644 0.291 0.146414634003 gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 0 0 2.88517E-04 3.87747E-04 None 0 0 4.41E-05 2.06954E-04 0
R/H 14693 Ig-98 19 rs746380621 0.0576 -0.659 1.0 N 0.644 0.291 0.146414634003 gnomAD-4.0.0 4.71128E-05 None None None None N None 2.67058E-05 5.0045E-05 None 4.05625E-04 4.69211E-04 None 0 0 1.69563E-05 1.31775E-04 9.612E-05
T/A 14782 Ig-99 18 rs780249806 0.1014 -0.785 0.962 D 0.523 0.343 0.162503812791 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
T/A 14782 Ig-99 18 rs780249806 0.1014 -0.785 0.962 D 0.523 0.343 0.162503812791 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 2.78552E-05 None 0 0 0 0 0
V/A 14871 Ig-100 19 rs2058765049 0.2824 None 0.625 N 0.521 0.185 0.287603790349 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 14871 Ig-100 19 rs2058765049 0.2824 None 0.625 N 0.521 0.185 0.287603790349 gnomAD-4.0.0 2.03041E-06 None None None None N None 1.74825E-05 0 None 0 0 None 0 0 1.2051E-06 0 0
R/P 14960 Ig-101 19 rs764153170 0.9479 None 0.996 D 0.545 0.279 0.297718772494 gnomAD-3.1.2 6.6E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/P 14960 Ig-101 19 rs764153170 0.9479 None 0.996 D 0.545 0.279 0.297718772494 gnomAD-4.0.0 6.59544E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47384E-05 0 0
R/Q 14960 Ig-101 19 rs764153170 0.1459 -0.265 0.958 N 0.54 0.168 None gnomAD-2.1.1 2.07E-05 None None None None N None 0 1.18455E-04 None 0 0 None 0 None 0 9.13E-06 0
R/Q 14960 Ig-101 19 rs764153170 0.1459 -0.265 0.958 N 0.54 0.168 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.58E-05 0 0 0 None 0 0 1.47E-05 0 0
R/Q 14960 Ig-101 19 rs764153170 0.1459 -0.265 0.958 N 0.54 0.168 None gnomAD-4.0.0 1.18234E-05 None None None None N None 0 8.41978E-05 None 0 0 None 0 0 1.01974E-05 2.22856E-05 0
E/V 15138 Ig-103 19 None 0.2993 None 0.263 N 0.474 0.178 0.310147130316 gnomAD-4.0.0 1.59503E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43484E-05 0
V/A 15409 Ig-106 19 None 0.3097 None 0.826 D 0.583 0.467 0.725541513621 gnomAD-4.0.0 1.72961E-06 None None None None N None 0 0 None 0 0 None 0 0 3.07486E-06 0 0
V/I 15409 Ig-106 19 rs2058073034 0.0783 None 0.134 D 0.289 0.331 0.638268574249 gnomAD-4.0.0 1.41639E-06 None None None None N None 0 0 None 0 0 None 0 0 1.83935E-06 0 0
T/S 15586 Ig-108 19 rs764917649 0.1261 -0.767 0.98 N 0.512 0.138 0.143124449307 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.67504E-04
T/S 15586 Ig-108 19 rs764917649 0.1261 -0.767 0.98 N 0.512 0.138 0.143124449307 gnomAD-4.0.0 1.59713E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.04044E-05
T/M 15981 Ig-109 14 rs150364979 0.1271 -0.074 0.702 N 0.457 0.123 None gnomAD-2.1.1 3.94E-05 None None None None N None 1.24121E-04 0 None 0 0 None 0 None 0 6.29E-05 0
T/M 15981 Ig-109 14 rs150364979 0.1271 -0.074 0.702 N 0.457 0.123 None gnomAD-3.1.2 4.61E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 5.89E-05 0 0
T/M 15981 Ig-109 14 rs150364979 0.1271 -0.074 0.702 N 0.457 0.123 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
T/M 15981 Ig-109 14 rs150364979 0.1271 -0.074 0.702 N 0.457 0.123 None gnomAD-4.0.0 3.53451E-05 None None None None N None 8.0094E-05 0 None 0 2.23524E-05 None 0 0 4.1557E-05 0 1.60205E-05
E/K 16277 Ig-110 16 rs1325831010 0.4668 -0.431 0.999 N 0.593 0.391 0.248417906384 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
E/K 16277 Ig-110 16 rs1325831010 0.4668 -0.431 0.999 N 0.593 0.391 0.248417906384 gnomAD-4.0.0 1.59478E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86375E-06 0 0
S/G 16973 Ig-111 19 rs943563172 0.112 None 0.012 N 0.501 0.063 0.117506650769 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
S/N 16973 Ig-111 19 None 0.0806 None None N 0.283 0.035 0.0551355673512 gnomAD-4.0.0 6.84671E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65859E-05
A/T 17266 Ig-112 16 None 0.072 None None N 0.319 0.091 0.0884992946249 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
R/G 17691 Ig-113 15 rs1450047709 0.5225 -1.033 0.324 N 0.529 0.181 0.33340067248 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
R/G 17691 Ig-113 15 rs1450047709 0.5225 -1.033 0.324 N 0.529 0.181 0.33340067248 gnomAD-4.0.0 5.47579E-06 None None None None N None 0 0 None 0 2.52296E-05 None 0 0 6.29802E-06 0 0
H/Q 17985 Ig-114 18 rs374042312 0.0996 None 0.006 N 0.235 0.032 0.124217242631 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
H/Q 17985 Ig-114 18 rs374042312 0.0996 None 0.006 N 0.235 0.032 0.124217242631 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/Q 17985 Ig-114 18 rs374042312 0.0996 None 0.006 N 0.235 0.032 0.124217242631 gnomAD-4.0.0 3.85367E-06 None None None None N None 0 0 None 0 0 None 0 0 7.1948E-06 0 0
R/P 19111 Ig-117 17 rs375808207 0.9946 -0.547 1.0 N 0.73 0.515 0.490144168196 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
R/P 19111 Ig-117 17 rs375808207 0.9946 -0.547 1.0 N 0.73 0.515 0.490144168196 gnomAD-4.0.0 6.84436E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9963E-07 0 0
R/Q 19111 Ig-117 17 rs375808207 0.4576 -0.252 1.0 N 0.691 0.377 None gnomAD-2.1.1 1.07E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 1.57E-05 0
R/Q 19111 Ig-117 17 rs375808207 0.4576 -0.252 1.0 N 0.691 0.377 None gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/Q 19111 Ig-117 17 rs375808207 0.4576 -0.252 1.0 N 0.691 0.377 None gnomAD-4.0.0 1.05391E-05 None None None None N None 2.67144E-05 0 None 3.37998E-05 2.23814E-05 None 0 0 1.01735E-05 1.09823E-05 0
A/D 19405 Ig-118 15 None 0.4035 None 0.175 N 0.452 0.206 0.281780670237 gnomAD-4.0.0 2.05319E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69878E-06 0 0
A/T 19405 Ig-118 15 None 0.0722 None 0.001 N 0.201 0.087 0.130388298395 gnomAD-4.0.0 6.36894E-06 None None None None I None 0 0 None 0 0 None 0 0 1.14378E-05 0 0
A/V 19405 Ig-118 15 None 0.0957 None None N 0.182 0.071 0.15556083564 gnomAD-4.0.0 6.84398E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99594E-07 0 0
R/K 20097 Ig-120 18 None 0.1425 None 0.997 N 0.545 0.27 0.211220785272 gnomAD-4.0.0 1.61338E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88869E-06 0 0
R/C 20495 Ig-121 17 rs370128504 0.1694 -0.508 0.964 N 0.525 0.389 None gnomAD-2.1.1 1.77E-05 None None None None N None 0 0 None 0 0 None 4.07E-05 None 0 1.92E-05 1.8622E-04
R/C 20495 Ig-121 17 rs370128504 0.1694 -0.508 0.964 N 0.525 0.389 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 2.07727E-04 0
R/C 20495 Ig-121 17 rs370128504 0.1694 -0.508 0.964 N 0.525 0.389 None gnomAD-4.0.0 2.5809E-05 None None None None N None 0 0 None 0 0 None 0 0 2.74081E-05 8.15756E-05 3.25924E-05
R/G 20495 Ig-121 17 rs370128504 0.3363 -0.82 0.058 N 0.501 0.38 0.370240404367 gnomAD-2.1.1 3.09E-05 None None None None N None 0 2.18259E-04 None 0 0 None 0 None 0 0 0
R/G 20495 Ig-121 17 rs370128504 0.3363 -0.82 0.058 N 0.501 0.38 0.370240404367 gnomAD-4.0.0 5.56867E-06 None None None None N None 0 1.64923E-04 None 0 0 None 0 0 9.0944E-07 0 0
R/H 20495 Ig-121 17 rs775137607 0.0935 -1.116 None N 0.31 0.114 None gnomAD-2.1.1 5.81E-05 None None None None N None 1.25429E-04 0 None 0 0 None 0 None 0 1.00284E-04 0
R/H 20495 Ig-121 17 rs775137607 0.0935 -1.116 None N 0.31 0.114 None gnomAD-3.1.2 1.11849E-04 None None None None N None 1.44872E-04 0 0 0 0 None 0 0 1.47158E-04 2.07039E-04 0
R/H 20495 Ig-121 17 rs775137607 0.0935 -1.116 None N 0.31 0.114 None gnomAD-4.0.0 5.16057E-05 None None None None N None 1.21336E-04 0 None 0 0 None 0 1.68407E-04 5.82365E-05 1.16293E-05 4.88743E-05
R/L 20495 Ig-121 17 rs775137607 0.2965 0.295 0.13 N 0.523 0.166 0.273938319068 gnomAD-2.1.1 8.82E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.92E-05 0
R/L 20495 Ig-121 17 rs775137607 0.2965 0.295 0.13 N 0.523 0.166 0.273938319068 gnomAD-4.0.0 2.78362E-06 None None None None N None 0 0 None 0 0 None 0 0 3.63737E-06 0 0
R/K 20788 Ig-122 20 None 0.0811 None 0.006 N 0.343 0.06 0.107399877778 gnomAD-4.0.0 1.59205E-06 None None None None N None 0 0 None 0 2.77963E-05 None 0 0 0 0 0
R/S 20788 Ig-122 20 None 0.2469 None 0.477 N 0.644 0.175 0.149567049428 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 21193 Ig-123 17 rs376800688 0.6461 -0.594 1.0 N 0.739 0.366 None gnomAD-2.1.1 2.86899E-04 None None None None I None 0 2.84E-05 None 0 0 None 0 None 4.02E-05 5.96556E-04 2.82566E-04
R/C 21193 Ig-123 17 rs376800688 0.6461 -0.594 1.0 N 0.739 0.366 None gnomAD-3.1.2 3.35597E-04 None None None None I None 1.69074E-04 3.93597E-04 0 0 0 None 0 3.16456E-03 5.44438E-04 0 0
R/C 21193 Ig-123 17 rs376800688 0.6461 -0.594 1.0 N 0.739 0.366 None gnomAD-4.0.0 4.51428E-04 None None None None I None 1.06732E-04 1.16799E-04 None 0 0 None 6.25508E-05 1.65399E-04 5.79169E-04 3.29736E-05 3.52429E-04
R/H 21193 Ig-123 17 rs372267046 0.3722 -1.142 1.0 N 0.765 0.432 None gnomAD-2.1.1 7.89E-05 None None None None I None 4.14E-05 8.52E-05 None 0 0 None 1.31027E-04 None 0 7.07E-05 7.06614E-04
R/H 21193 Ig-123 17 rs372267046 0.3722 -1.142 1.0 N 0.765 0.432 None gnomAD-3.1.2 7.24E-05 None None None None I None 7.25E-05 2.62433E-04 0 0 1.94401E-04 None 0 0 2.94E-05 0 4.78927E-04
R/H 21193 Ig-123 17 rs372267046 0.3722 -1.142 1.0 N 0.765 0.432 None gnomAD-4.0.0 9.1164E-05 None None None None I None 5.34559E-05 1.00164E-04 None 0 2.23964E-05 None 0 8.23995E-04 9.66716E-05 1.20892E-04 9.61508E-05
R/Q 21485 Ig-124 17 rs746903647 0.2145 0.025 0.999 N 0.534 0.316 0.18274738541 gnomAD-2.1.1 2.43E-05 None None None None N None 0 5.85E-05 None 0 0 None 6.62E-05 None 0 1.79E-05 0
R/Q 21485 Ig-124 17 rs746903647 0.2145 0.025 0.999 N 0.534 0.316 0.18274738541 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 1.94099E-04 None 0 0 0 0 0
R/Q 21485 Ig-124 17 rs746903647 0.2145 0.025 0.999 N 0.534 0.316 0.18274738541 gnomAD-4.0.0 2.66823E-05 None None None None N None 2.67723E-05 1.67442E-05 None 0 2.23234E-05 None 0 0 2.46008E-05 7.72116E-05 4.80923E-05
C/G 21882 Ig-125 17 rs1440309289 0.2688 -1.506 0.285 N 0.427 0.241 0.463843524616 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.64E-05 None 0 None 0 0 0
C/G 21882 Ig-125 17 rs1440309289 0.2688 -1.506 0.285 N 0.427 0.241 0.463843524616 gnomAD-4.0.0 1.59444E-06 None None None None N None 0 0 None 0 2.79033E-05 None 0 0 0 0 0
R/Q 22569 Ig-127 10 rs185620750 0.1393 -0.035 0.997 N 0.597 0.274 None gnomAD-2.1.1 1.62599E-04 None None None None I None 6.47E-05 9.62324E-04 None 0 1.68388E-04 None 6.61E-05 None 0 0 1.6728E-04
R/Q 22569 Ig-127 10 rs185620750 0.1393 -0.035 0.997 N 0.597 0.274 None gnomAD-3.1.2 2.82876E-04 None None None None I None 2.41E-05 2.62261E-03 0 0 3.87597E-04 None 0 0 0 0 0
R/Q 22569 Ig-127 10 rs185620750 0.1393 -0.035 0.997 N 0.597 0.274 None 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
R/Q 22569 Ig-127 10 rs185620750 0.1393 -0.035 0.997 N 0.597 0.274 None gnomAD-4.0.0 7.40089E-05 None None None None I None 2.67401E-05 1.28849E-03 None 0 2.46316E-04 None 0 0 2.20982E-05 2.20361E-05 1.60705E-05
R/W 22569 Ig-127 10 rs746313264 0.2412 -0.317 1.0 N 0.683 0.411 None gnomAD-2.1.1 3.97E-05 None None None None I None 2.48488E-04 0 None 0 2.06825E-04 None 0 None 0 7.86E-06 0
R/W 22569 Ig-127 10 rs746313264 0.2412 -0.317 1.0 N 0.683 0.411 None gnomAD-3.1.2 5.26E-05 None None None None I None 1.20668E-04 6.56E-05 0 0 1.93798E-04 None 0 0 1.47E-05 0 0
R/W 22569 Ig-127 10 rs746313264 0.2412 -0.317 1.0 N 0.683 0.411 None gnomAD-4.0.0 3.04839E-05 None None None None I None 2.14242E-04 1.67471E-05 None 0 6.71862E-05 None 0 0 2.21002E-05 2.20371E-05 1.60777E-05
V/A 22965 Ig-128 16 None 0.1329 None 0.027 N 0.633 0.159 0.310147130316 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/K 24447 Ig-132 17 rs377190830 0.4368 -0.275 0.997 N 0.523 0.233 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/K 24447 Ig-132 17 rs377190830 0.4368 -0.275 0.997 N 0.523 0.233 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/K 24447 Ig-132 17 rs377190830 0.4368 -0.275 0.997 N 0.523 0.233 None gnomAD-4.0.0 5.57846E-06 None None None None N None 1.06852E-04 0 None 0 0 None 0 0 8.47738E-07 0 0
K/E 24734 Ig-133 19 rs546829047 0.3797 -0.094 0.958 N 0.532 0.28 0.253205268125 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/E 24734 Ig-133 19 rs546829047 0.3797 -0.094 0.958 N 0.532 0.28 0.253205268125 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
K/E 24734 Ig-133 19 rs546829047 0.3797 -0.094 0.958 N 0.532 0.28 0.253205268125 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/E 24734 Ig-133 19 rs546829047 0.3797 -0.094 0.958 N 0.532 0.28 0.253205268125 gnomAD-4.0.0 5.12727E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.36164E-05 0
K/N 24734 Ig-133 19 None 0.6495 None 0.988 N 0.662 0.168 0.112648838833 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
R/K 25529 Ig-135 16 rs750282861 0.34 0.1 0.014 N 0.312 0.173 0.104622674875 gnomAD-2.1.1 2.42E-05 None None None None I None 0 1.74571E-04 None 0 0 None 0 None 0 0 0
R/K 25529 Ig-135 16 rs750282861 0.34 0.1 0.014 N 0.312 0.173 0.104622674875 gnomAD-4.0.0 4.10715E-06 None None None None I None 0 1.34391E-04 None 0 0 None 0 0 0 0 0
R/S 26212 Ig-137 20 rs756880931 0.3029 -0.619 0.001 N 0.287 0.211 0.0954503805726 gnomAD-4.0.0 6.84549E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16104E-05 0
R/T 26212 Ig-137 20 rs11685237 0.1217 None 0.001 N 0.277 0.264 0.154104182512 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/T 26212 Ig-137 20 rs11685237 0.1217 None 0.001 N 0.277 0.264 0.154104182512 gnomAD-4.0.0 6.5754E-06 None None None None N None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
R/G 26611 Ig-138 18 rs745409995 0.6099 -0.487 1.0 N 0.671 0.493 0.452450644169 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
R/G 26611 Ig-138 18 rs745409995 0.6099 -0.487 1.0 N 0.671 0.493 0.452450644169 gnomAD-4.0.0 3.76337E-05 None None None None N None 0 0 None 0 0 None 0 0 4.94737E-05 0 0
K/N 26898 Ig-139 19 rs372650410 0.468 None 1.0 N 0.735 0.249 0.17948927462 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85951E-06 0 0
V/A 27294 Ig-140 17 None 0.1174 None 0.704 N 0.435 0.128 0.387202362727 gnomAD-4.0.0 1.59253E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85822E-06 0 0
V/G 27294 Ig-140 17 rs876658084 0.1801 None 0.92 N 0.546 0.278 0.590137622951 gnomAD-4.0.0 1.59253E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
V/I 27294 Ig-140 17 None 0.0687 None 0.061 N 0.178 0.132 0.330331372229 gnomAD-4.0.0 1.36892E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99468E-07 1.15931E-05 0
R/C 27694 Ig-141 19 rs192360370 0.8231 -0.211 1.0 N 0.739 0.513 None gnomAD-2.1.1 3.03305E-04 None None None None I None 0 2.83E-05 None 0 3.9471E-03 None 0 None 0 3.9E-05 2.80505E-04
R/C 27694 Ig-141 19 rs192360370 0.8231 -0.211 1.0 N 0.739 0.513 None gnomAD-3.1.2 1.2498E-04 None None None None I None 2.42E-05 0 0 0 3.48432E-03 None 0 0 0 0 0
R/C 27694 Ig-141 19 rs192360370 0.8231 -0.211 1.0 N 0.739 0.513 None 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 3E-03 0 None None None 0 None
R/C 27694 Ig-141 19 rs192360370 0.8231 -0.211 1.0 N 0.739 0.513 None gnomAD-4.0.0 2.28682E-04 None None None None I None 1.33369E-05 5.00117E-05 None 0 7.40311E-03 None 0 0 2.37353E-05 0 8.00307E-05
R/H 27694 Ig-141 19 rs775499341 0.484 -0.603 1.0 N 0.751 0.434 0.270001397563 gnomAD-2.1.1 1.71307E-04 None None None None I None 4.13E-05 2.83E-05 None 0 2.1017E-03 None 0 None 0 3.9E-05 0
R/H 27694 Ig-141 19 rs775499341 0.484 -0.603 1.0 N 0.751 0.434 0.270001397563 gnomAD-3.1.2 5.92E-05 None None None None I None 0 0 0 0 9.68242E-04 None 0 0 5.88E-05 0 0
R/H 27694 Ig-141 19 rs775499341 0.484 -0.603 1.0 N 0.751 0.434 0.270001397563 gnomAD-4.0.0 5.20616E-05 None None None None I None 4.00695E-05 3.33578E-05 None 0 6.01953E-04 None 0 0 4.15362E-05 0 4.80369E-05
K/Q 27981 Ig-142 19 rs1472389863 0.128 0.403 0.82 N 0.593 0.182 0.176091768786 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
K/Q 27981 Ig-142 19 rs1472389863 0.128 0.403 0.82 N 0.593 0.182 0.176091768786 gnomAD-4.0.0 1.59331E-06 None None None None N None 0 2.29211E-05 None 0 0 None 0 0 0 0 0
K/Q 28376 Ig-143 19 rs755843409 0.1201 -0.289 0.967 N 0.653 0.128 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 1.78E-05 0
K/Q 28376 Ig-143 19 rs755843409 0.1201 -0.289 0.967 N 0.653 0.128 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/Q 28376 Ig-143 19 rs755843409 0.1201 -0.289 0.967 N 0.653 0.128 None gnomAD-4.0.0 2.04492E-05 None None None None N None 0 3.33444E-05 None 0 0 None 0 0 2.54278E-05 0 1.60108E-05
K/T 28376 Ig-143 19 None 0.1518 None 0.967 N 0.705 0.306 0.177238962908 gnomAD-4.0.0 7.20195E-06 None None None None N None 0 0 None 0 0 None 0 0 7.87503E-06 0 0
T/A 28773 Ig-144 19 None 0.1117 None 0.63 N 0.457 0.225 0.20549828249 gnomAD-4.0.0 1.59991E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43658E-05 0
K/Q 29063 Ig-145 19 None 0.1995 None 1.0 N 0.685 0.35 0.193865811164 gnomAD-4.0.0 1.43224E-05 None None None None N None 0 0 None 0 0 None 0 0 2.57218E-05 0 0
Q/E 29858 Ig-147 17 None 0.094 None None N 0.213 0.106 0.101711395817 gnomAD-4.0.0 1.37714E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80106E-06 0 0
Q/K 29858 Ig-147 17 rs1316523481 0.0876 0.146 0.012 N 0.449 0.126 0.0986583533028 gnomAD-2.1.1 4.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
Q/K 29858 Ig-147 17 rs1316523481 0.0876 0.146 0.012 N 0.449 0.126 0.0986583533028 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/K 29858 Ig-147 17 rs1316523481 0.0876 0.146 0.012 N 0.449 0.126 0.0986583533028 gnomAD-4.0.0 9.97241E-06 None None None None N None 0 0 None 0 0 None 0 0 1.35768E-05 0 0
H/P 30150 Ig-148 19 None 0.4787 None 0.996 N 0.61 0.344 0.321951552304 gnomAD-4.0.0 1.60908E-06 None None None None N None 0 0 None 0 0 None 0 0 2.9032E-06 0 0
H/Q 30150 Ig-148 19 None 0.2467 None 0.988 N 0.551 0.302 0.206339911435 gnomAD-4.0.0 6.87602E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04035E-07 0 0
H/Y 30150 Ig-148 19 rs1166895783 0.1266 1.289 0.996 N 0.554 0.377 0.221019684889 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.31E-05 None 0 0 0
H/Y 30150 Ig-148 19 rs1166895783 0.1266 1.289 0.996 N 0.554 0.377 0.221019684889 gnomAD-4.0.0 1.60877E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44013E-05 0
R/K 30545 Ig-149 14 None 0.1179 None 0.011 N 0.271 0.106 0.104622674875 gnomAD-4.0.0 1.20038E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31256E-06 0 0
R/C 30944 Ig-150 18 rs1393282264 0.2167 -0.25 1.0 N 0.478 0.452 0.57026793815 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/C 30944 Ig-150 18 rs1393282264 0.2167 -0.25 1.0 N 0.478 0.452 0.57026793815 gnomAD-4.0.0 8.90155E-06 None None None None I None 0 2.23634E-05 None 0 2.51991E-05 None 0 0 8.99476E-06 1.15934E-05 0
R/H 30944 Ig-150 18 rs755972883 0.1145 -0.852 0.169 N 0.321 0.218 None gnomAD-2.1.1 1.21749E-04 None None None None I None 4.13E-05 5.66E-05 None 0 0 None 0 None 9.50728E-04 6.25E-05 0
R/H 30944 Ig-150 18 rs755972883 0.1145 -0.852 0.169 N 0.321 0.218 None gnomAD-3.1.2 9.2E-05 None None None None I None 0 0 0 0 0 None 9.42329E-04 0 5.88E-05 0 0
R/H 30944 Ig-150 18 rs755972883 0.1145 -0.852 0.169 N 0.321 0.218 None gnomAD-4.0.0 5.9536E-05 None None None None I None 0 3.33378E-05 None 0 0 None 6.04903E-04 0 4.57716E-05 1.09784E-05 1.60118E-05
R/S 30944 Ig-150 18 rs1393282264 0.6017 None 0.858 N 0.5 0.296 0.305410167561 gnomAD-4.0.0 2.0542E-06 None None None None I None 0 6.70901E-05 None 0 0 None 0 0 0 0 0
T/I 31234 Ig-151 17 rs548911604 0.1177 None 0.997 N 0.719 0.396 0.351614576976 gnomAD-4.0.0 4.10517E-06 None None None None N None 1.49379E-04 0 None 0 0 None 0 0 0 0 1.65651E-05
V/G 31634 Ig-152 14 rs1697167076 0.4894 None 1.0 N 0.77 0.578 0.699185091952 gnomAD-4.0.0 2.05272E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69848E-06 0 0
V/L 31634 Ig-152 14 rs762250254 0.1973 0.022 0.997 N 0.511 0.232 0.42538462244 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/L 31634 Ig-152 14 rs762250254 0.1973 0.022 0.997 N 0.511 0.232 0.42538462244 gnomAD-4.0.0 1.59143E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8585E-06 0 0
R/C 32033 Ig-153 17 rs755271215 0.5351 -0.646 1.0 N 0.745 0.534 0.665552289088 gnomAD-2.1.1 2.01E-05 None None None None N None 0 2.9E-05 None 0 5.57E-05 None 0 None 0 2.67E-05 0
R/C 32033 Ig-153 17 rs755271215 0.5351 -0.646 1.0 N 0.745 0.534 0.665552289088 gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.56E-05 0 0 1.92827E-04 None 0 0 0 0 0
R/C 32033 Ig-153 17 rs755271215 0.5351 -0.646 1.0 N 0.745 0.534 0.665552289088 gnomAD-4.0.0 2.04529E-05 None None None None N None 0 3.33389E-05 None 0 2.67451E-04 None 0 1.65235E-04 1.52586E-05 0 0
R/H 32033 Ig-153 17 rs200648462 0.2348 -1.42 1.0 N 0.738 0.427 None gnomAD-2.1.1 3.7154E-04 None None None None N None 3.22447E-03 4.8096E-04 None 1.93424E-04 5.12E-05 None 3.27E-05 None 0 3.91E-05 0
R/H 32033 Ig-153 17 rs200648462 0.2348 -1.42 1.0 N 0.738 0.427 None gnomAD-3.1.2 8.68056E-04 None None None None N None 2.87467E-03 3.27826E-04 0 5.76037E-04 0 None 0 0 7.35E-05 2.07469E-04 0
R/H 32033 Ig-153 17 rs200648462 0.2348 -1.42 1.0 N 0.738 0.427 None 1000 genomes 9.98403E-04 None None None None N None 3.8E-03 0 None None 0 0 None None None 0 None
R/H 32033 Ig-153 17 rs200648462 0.2348 -1.42 1.0 N 0.738 0.427 None gnomAD-4.0.0 1.84686E-04 None None None None N None 2.68079E-03 4.00053E-04 None 2.02716E-04 2.22856E-05 None 0 0 3.89935E-05 4.39252E-05 2.56115E-04
E/Q 32325 Ig-154 19 rs1196060333 0.1575 -0.087 0.994 N 0.598 0.208 0.19670166235 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
E/Q 32325 Ig-154 19 rs1196060333 0.1575 -0.087 0.994 N 0.598 0.208 0.19670166235 gnomAD-4.0.0 2.7371E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59831E-06 0 0
R/S 32723 Ig-155 16 rs753058072 0.8364 -1.116 0.062 N 0.465 0.154 0.141422826196 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.88E-06 0
R/S 32723 Ig-155 16 rs753058072 0.8364 -1.116 0.062 N 0.465 0.154 0.141422826196 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 32723 Ig-155 16 rs753058072 0.8364 -1.116 0.062 N 0.465 0.154 0.141422826196 gnomAD-4.0.0 9.29525E-06 None None None None N None 0 0 None 0 0 None 0 1.64366E-04 6.78093E-06 4.39116E-05 3.20215E-05
Q/R 33119 Ig-156 19 rs775783429 0.1142 0.596 0.166 N 0.495 0.162 0.119812018005 gnomAD-2.1.1 2.42E-05 None None None None N None 0 0 None 0 0 None 1.96258E-04 None 0 0 0
Q/R 33119 Ig-156 19 rs775783429 0.1142 0.596 0.166 N 0.495 0.162 0.119812018005 gnomAD-4.0.0 2.06933E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.71984E-04 3.02462E-05
R/P 33215 Ig-157 13 rs373182320 0.985 0.101 1.0 N 0.719 0.465 0.403040389579 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66003E-04
R/P 33215 Ig-157 13 rs373182320 0.985 0.101 1.0 N 0.719 0.465 0.403040389579 gnomAD-4.0.0 2.73691E-06 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 2.69842E-06 0 0
R/Q 33215 Ig-157 13 rs373182320 0.4732 0.089 1.0 N 0.704 0.351 None gnomAD-2.1.1 2.14E-05 None None None None N None 0 8.5E-05 None 0 0 None 0 None 0 2.34E-05 0
R/Q 33215 Ig-157 13 rs373182320 0.4732 0.089 1.0 N 0.704 0.351 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 33215 Ig-157 13 rs373182320 0.4732 0.089 1.0 N 0.704 0.351 None gnomAD-4.0.0 1.36339E-05 None None None None N None 0 5.00183E-05 None 0 2.22846E-05 None 0 1.6442E-04 1.44095E-05 0 0
R/W 33215 Ig-157 13 rs377598016 0.6789 -0.138 1.0 N 0.745 0.455 None gnomAD-2.1.1 5.22E-05 None None None None N None 0 0 None 0 0 None 2.61506E-04 None 0 4.43E-05 0
R/W 33215 Ig-157 13 rs377598016 0.6789 -0.138 1.0 N 0.745 0.455 None gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 5.88E-05 0 0
R/W 33215 Ig-157 13 rs377598016 0.6789 -0.138 1.0 N 0.745 0.455 None gnomAD-4.0.0 5.76281E-05 None None None None N None 1.33287E-05 1.66644E-05 None 0 2.22926E-05 None 0 0 6.27235E-05 1.64694E-04 1.60061E-05
T/A 33514 Ig-158 19 None 0.4198 None 0.988 N 0.512 0.325 0.338110398507 gnomAD-4.0.0 1.59256E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86017E-06 0 0
T/I 33514 Ig-158 19 None 0.723 None 1.0 N 0.756 0.475 0.494974121195 gnomAD-4.0.0 2.05337E-06 None None None None N None 2.98846E-05 0 None 0 0 None 0 0 0 1.16036E-05 1.65739E-05
S/N 33614 Ig-159 19 rs879230745 0.2005 None 0.018 N 0.291 0.086 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/N 33614 Ig-159 19 rs879230745 0.2005 None 0.018 N 0.291 0.086 None gnomAD-4.0.0 5.12999E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57474E-06 0 0
R/L 34276 Ig-161 19 None 0.4359 None 0.993 N 0.657 0.403 0.355034743287 gnomAD-4.0.0 6.84158E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99412E-07 0 0
R/Q 34276 Ig-161 19 rs199932621 0.1523 -0.427 0.997 N 0.683 0.348 0.0954503805726 gnomAD-2.1.1 3.92E-05 None None None None N None 0 1.41411E-04 None 0 1.02501E-04 None 3.27E-05 None 4E-05 1.56E-05 0
R/Q 34276 Ig-161 19 rs199932621 0.1523 -0.427 0.997 N 0.683 0.348 0.0954503805726 gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 1.92901E-04 None 0 0 4.41E-05 0 0
R/Q 34276 Ig-161 19 rs199932621 0.1523 -0.427 0.997 N 0.683 0.348 0.0954503805726 gnomAD-4.0.0 2.41662E-05 None None None None N None 2.66951E-05 1.16674E-04 None 0 2.22826E-05 None 1.56245E-05 1.64366E-04 2.03412E-05 2.19568E-05 1.60097E-05
R/W 34276 Ig-161 19 rs781432886 0.3688 -0.341 1.0 N 0.716 0.298 0.19670166235 gnomAD-2.1.1 3.61E-05 None None None None N None 0 2.02852E-04 None 0 0 None 0 None 0 1.77E-05 0
R/W 34276 Ig-161 19 rs781432886 0.3688 -0.341 1.0 N 0.716 0.298 0.19670166235 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 9.43E-05 0 1.47E-05 2.07469E-04 0
R/W 34276 Ig-161 19 rs781432886 0.3688 -0.341 1.0 N 0.716 0.298 0.19670166235 gnomAD-4.0.0 1.17735E-05 None None None None N None 0 1.16671E-04 None 0 2.22806E-05 None 1.56245E-05 0 5.08532E-06 2.19592E-05 3.20195E-05
C/F 34381 Ig-162 19 rs1357763703 0.5671 -1.428 0.882 N 0.558 0.334 0.757505148635 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
C/F 34381 Ig-162 19 rs1357763703 0.5671 -1.428 0.882 N 0.558 0.334 0.757505148635 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
C/F 34381 Ig-162 19 rs1357763703 0.5671 -1.428 0.882 N 0.558 0.334 0.757505148635 gnomAD-4.0.0 2.56314E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.68032E-05 0
C/S 34381 Ig-162 19 rs1357763703 0.4058 -1.799 0.006 N 0.25 0.338 0.50970329007 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
C/S 34381 Ig-162 19 rs1357763703 0.4058 -1.799 0.006 N 0.25 0.338 0.50970329007 gnomAD-4.0.0 4.7764E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.2991E-05 0
R/C 34960 Ig-163 19 rs772702110 0.128 -0.396 0.005 N 0.477 0.061 0.247872288689 gnomAD-2.1.1 2.41E-05 None None None None N None 0 5.79E-05 None 0 0 None 3.27E-05 None 0 2.66E-05 0
R/C 34960 Ig-163 19 rs772702110 0.128 -0.396 0.005 N 0.477 0.061 0.247872288689 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30907E-04 0 0 0 None 0 0 0 0 0
R/C 34960 Ig-163 19 rs772702110 0.128 -0.396 0.005 N 0.477 0.061 0.247872288689 gnomAD-4.0.0 2.16881E-05 None None None None N None 0 6.66689E-05 None 0 0 None 0 0 2.45791E-05 2.19582E-05 0
R/H 34960 Ig-163 19 rs1352552140 0.0993 None 0.005 N 0.428 0.085 0.0920862733494 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 34960 Ig-163 19 rs1352552140 0.0993 None 0.005 N 0.428 0.085 0.0920862733494 gnomAD-4.0.0 3.0983E-06 None None None None N None 0 0 None 0 0 None 1.56255E-05 0 3.39023E-06 0 0
R/P 34960 Ig-163 19 rs1352552140 0.9519 None 0.705 N 0.561 0.251 0.303781844768 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/P 34960 Ig-163 19 rs1352552140 0.9519 None 0.705 N 0.561 0.251 0.303781844768 gnomAD-4.0.0 6.57471E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47037E-05 0 0
R/S 34960 Ig-163 19 rs772702110 0.5142 None 0.251 N 0.505 0.104 0.0954503805726 gnomAD-4.0.0 6.84141E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99399E-07 0 0
R/S 35147 Ig-164 19 None 0.4765 None 0.961 N 0.592 0.272 0.198526703765 gnomAD-4.0.0 6.84137E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99394E-07 0 0
K/N 35302 Ig-165 17 None 0.6151 None 0.98 N 0.543 0.16 0.12205267543 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
K/E 35438 Ig-166 19 rs755067124 0.223 0.401 0.076 N 0.684 0.243 0.144782658237 gnomAD-2.1.1 8.03E-06 None None None None N None 1.29166E-04 0 None 0 0 None 0 None 0 0 0
K/E 35438 Ig-166 19 rs755067124 0.223 0.401 0.076 N 0.684 0.243 0.144782658237 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
K/E 35438 Ig-166 19 rs755067124 0.223 0.401 0.076 N 0.684 0.243 0.144782658237 gnomAD-4.0.0 3.09871E-06 None None None None N None 4.00427E-05 0 None 0 2.22787E-05 None 0 0 8.47709E-07 0 0
V/L 35625 Ig-167 19 rs1687747331 0.1582 None 0.001 N 0.419 0.108 0.19670166235 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85758E-06 0 0
L/I 35720 Ig-168 19 None 0.0639 None 0.01 N 0.478 0.044 0.252681307341 gnomAD-4.0.0 6.37355E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86126E-06 4.3075E-05 0
L/P 35720 Ig-168 19 None 0.8015 None 0.295 N 0.614 0.248 0.60282686728 gnomAD-4.0.0 6.84552E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99722E-07 0 0
L/R 35720 Ig-168 19 rs768060182 0.1241 -0.618 None N 0.517 0.204 0.411665641125 gnomAD-4.0.0 6.84552E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16144E-05 0
T/K 35915 Ig-169 19 rs768221453 0.7269 None 0.998 N 0.692 0.434 0.436993770938 gnomAD-4.0.0 3.18428E-06 None None None -2.693(OBSL1) -1.352(OBSCN) N None 1.13071E-04 0 None 0 0 None 0 0 0 0 0
T/P 35915 Ig-169 19 None 0.794 -0.588 0.999 N 0.751 0.467 0.48286525802 Evila (2016) None TMD comp het with E28338fs None -1.476(OBSL1) -0.66(OBSCN) N Genetic analysis of genes in 10 TMD families; co-segregation in 2-generation family (recessive inheritance, n = 3, 3 affected (total 4)); variant prioritisation; comp het with E28338fs None None None None None None None None None None None
T/P 35915 Ig-169 19 None 0.794 -0.588 0.999 N 0.751 0.467 0.48286525802 gnomAD-4.0.0 1.20032E-06 None None None -1.476(OBSL1) -0.66(OBSCN) N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.