Structural position:

  • Domain Type: Ig
  • Aligned Position: 34
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
H/D 28 Ig-1 23 rs752309578 0.3085 -0.664 0.09 N 0.494 0.443 0.35139820857 gnomAD-2.1.1 3.98E-06 None None None -0.275(TCAP) N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
H/Y 28 Ig-1 23 None 0.1445 None 0.846 N 0.481 0.315 0.472663046089 gnomAD-4.0.0 1.20036E-06 None None None 0.173(TCAP) N None 0 0 None 0 0 None 0 0 1.31254E-06 0 0
H/P 965 Ig-3 23 None 0.6287 None 0.784 N 0.589 0.44 0.539656846532 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
H/Y 965 Ig-3 23 rs761450193 0.1359 0.612 0.917 N 0.415 0.308 0.408853032482 gnomAD-2.1.1 7.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
H/Y 965 Ig-3 23 rs761450193 0.1359 0.612 0.917 N 0.415 0.308 0.408853032482 gnomAD-4.0.0 3.18112E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71318E-06 0 0
K/E 1313 Ig-5 23 None 0.5495 None 0.996 N 0.484 0.48 0.411531665326 gnomAD-4.0.0 6.84211E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99418E-07 0 0
K/N 1313 Ig-5 23 None 0.8197 None 0.999 N 0.679 0.37 0.250579442822 gnomAD-4.0.0 6.84239E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15945E-05 0
K/Q 1313 Ig-5 23 None 0.2337 None 0.999 N 0.669 0.482 0.289474373501 gnomAD-4.0.0 6.84211E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99418E-07 0 0
K/N 1479 Ig-6 23 None 0.9799 None 1.0 D 0.758 0.403 0.17948927462 gnomAD-4.0.0 2.73644E-06 None None None None I None 8.96432E-05 0 None 0 0 None 0 0 0 0 1.65596E-05
K/R 1479 Ig-6 23 rs566441215 0.2233 -0.553 0.999 N 0.509 0.428 0.341226946553 gnomAD-2.1.1 7.97E-06 None None None None I None 0 0 None 0 0 None 6.53E-05 None 0 0 0
K/R 1479 Ig-6 23 rs566441215 0.2233 -0.553 0.999 N 0.509 0.428 0.341226946553 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
K/R 1479 Ig-6 23 rs566441215 0.2233 -0.553 0.999 N 0.509 0.428 0.341226946553 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
K/R 1479 Ig-6 23 rs566441215 0.2233 -0.553 0.999 N 0.509 0.428 0.341226946553 gnomAD-4.0.0 1.36299E-05 None None None None I None 0 0 None 0 0 None 0 0 1.52547E-05 4.39165E-05 0
R/S 1725 Ig-8 23 None 0.966 None 1.0 D 0.769 0.441 0.276482976112 gnomAD-4.0.0 1.59066E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85652E-06 0 0
R/K 1863 Ig-9 23 None 0.5413 None 0.997 N 0.475 0.325 0.348983352498 gnomAD-4.0.0 2.05225E-06 None None None None I None 0 0 None 0 0 None 0 1.7343E-04 1.7986E-06 0 0
R/S 1863 Ig-9 23 rs763383772 0.9826 -1.125 1.0 N 0.752 0.492 0.222439326576 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.8E-06 0
R/I 2100 Ig-10 23 None 0.8578 None 1.0 D 0.769 0.59 0.761427779387 gnomAD-4.0.0 1.59069E-06 None None None None N None 0 0 None 0 2.775E-05 None 0 0 0 0 0
E/K 2197 Ig-11 24 rs139329751 0.5221 -0.752 0.999 D 0.527 0.476 0.494433119893 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 2197 Ig-11 24 rs139329751 0.5221 -0.752 0.999 D 0.527 0.476 0.494433119893 gnomAD-4.0.0 3.18157E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86541E-05 0
I/F 2289 Ig-12 23 None 0.1409 None 0.171 N 0.51 0.186 0.346544149963 gnomAD-4.0.0 3.18184E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71386E-06 0 0
I/S 2289 Ig-12 23 rs200440412 0.1543 -1.47 0.024 N 0.529 0.24 None gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.65E-05 0
I/S 2289 Ig-12 23 rs200440412 0.1543 -1.47 0.024 N 0.529 0.24 None gnomAD-4.0.0 2.5998E-05 None None None None N None 0 0 None 0 0 None 0 0 3.14775E-05 0 4.96771E-05
I/V 2289 Ig-12 23 rs1274078547 0.063 None None N 0.129 0.089 0.435915822735 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 2289 Ig-12 23 rs1274078547 0.063 None None N 0.129 0.089 0.435915822735 gnomAD-4.0.0 3.84226E-06 None None None None N None 1.69062E-05 0 None 0 0 None 0 0 4.78396E-06 0 0
K/R 2378 Ig-13 23 rs727503690 0.113 -0.483 0.031 N 0.203 0.281 0.235038932564 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/R 2378 Ig-13 23 rs727503690 0.113 -0.483 0.031 N 0.203 0.281 0.235038932564 gnomAD-4.0.0 6.36256E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73099E-05 0
K/E 2467 Ig-14 23 rs1362423521 0.4061 -1.243 0.999 N 0.557 0.551 0.418964662724 gnomAD-2.1.1 1.42E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.11E-05 0
K/E 2467 Ig-14 23 rs1362423521 0.4061 -1.243 0.999 N 0.557 0.551 0.418964662724 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 2467 Ig-14 23 rs1362423521 0.4061 -1.243 0.999 N 0.557 0.551 0.418964662724 gnomAD-4.0.0 6.19603E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47478E-06 0 0
K/N 2467 Ig-14 23 rs757495201 0.7122 None 1.0 D 0.752 0.439 0.202086224978 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
K/N 2467 Ig-14 23 rs757495201 0.7122 None 1.0 D 0.752 0.439 0.202086224978 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 2467 Ig-14 23 rs757495201 0.7122 None 1.0 D 0.752 0.439 0.202086224978 gnomAD-4.0.0 1.85889E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54245E-06 0 0
K/R 2467 Ig-14 23 rs1184349328 0.1122 -0.684 0.999 N 0.489 0.451 0.373173300195 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/R 2467 Ig-14 23 rs1184349328 0.1122 -0.684 0.999 N 0.489 0.451 0.373173300195 gnomAD-4.0.0 1.59074E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
E/K 2555 Ig-15 23 None 0.6756 None 0.999 D 0.471 0.455 0.389439708392 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/G 2642 Ig-16 22 None 0.4097 None 0.999 D 0.748 0.581 0.527251791467 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
E/K 2642 Ig-16 22 None 0.1957 None 0.992 D 0.509 0.426 0.377097596864 gnomAD-4.0.0 1.59089E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85734E-06 0 0
E/D 2729 Ig-17 23 None 0.5313 None 0.999 D 0.467 0.357 0.302793454619 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 2729 Ig-17 23 rs763702243 0.4712 -0.53 1.0 D 0.52 0.439 0.447803500395 gnomAD-2.1.1 1.06E-05 None None None None N None 0 2.82E-05 None 0 0 None 0 None 0 1.55E-05 0
E/K 2729 Ig-17 23 rs763702243 0.4712 -0.53 1.0 D 0.52 0.439 0.447803500395 gnomAD-3.1.2 8.54E-05 None None None None N None 0 6.54793E-04 0 0 0 None 0 0 4.41E-05 0 0
E/K 2729 Ig-17 23 rs763702243 0.4712 -0.53 1.0 D 0.52 0.439 0.447803500395 gnomAD-4.0.0 2.17715E-05 None None None None N None 0 1.86428E-04 None 0 0 None 0 0 1.19587E-05 0 2.84204E-05
E/K 2904 Ig-19 23 rs794729583 0.7948 None 0.999 D 0.555 0.583 0.499858025796 gnomAD-4.0.0 6.15665E-06 None None None None N None 0 0 None 0 2.51965E-05 None 0 0 0 1.15931E-05 1.15902E-04
E/D 3080 Ig-21 23 None 0.8614 None 0.999 D 0.428 0.472 0.272205846399 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
E/G 3080 Ig-21 23 rs1305956743 0.939 None 1.0 D 0.756 0.685 0.621290578936 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 3080 Ig-21 23 rs1305956743 0.939 None 1.0 D 0.756 0.685 0.621290578936 gnomAD-4.0.0 6.57039E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
E/Q 3080 Ig-21 23 None 0.669 None 1.0 D 0.603 0.326 0.369867359543 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 3261 Ig-23 23 rs2291311 0.1706 None 0.679 N 0.487 0.203 0.426436156839 gnomAD-4.0.0 4.10457E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39583E-06 0 0
V/M 3261 Ig-23 23 rs2291311 0.1047 -0.845 0.988 N 0.588 0.235 None gnomAD-2.1.1 8.44463E-01 None None None None N None 8.29898E-01 5.72776E-01 None 9.13783E-01 7.69246E-01 None 7.88893E-01 None 8.9176E-01 9.30365E-01 8.75902E-01
V/M 3261 Ig-23 23 rs2291311 0.1047 -0.845 0.988 N 0.588 0.235 None gnomAD-3.1.2 8.69609E-01 None None None None N None 8.30739E-01 7.18902E-01 9.51754E-01 9.18491E-01 7.9059E-01 None 8.91522E-01 9.49367E-01 9.30493E-01 7.91373E-01 8.93881E-01
V/M 3261 Ig-23 23 rs2291311 0.1047 -0.845 0.988 N 0.588 0.235 None 1000 genomes 8.04912E-01 None None None None N None 8.253E-01 6.671E-01 None None 7.847E-01 9.145E-01 None None None 7.832E-01 None
V/M 3261 Ig-23 23 rs2291311 0.1047 -0.845 0.988 N 0.588 0.235 None gnomAD-4.0.0 9.0011E-01 None None None None N None 8.29923E-01 6.19412E-01 None 9.17016E-01 7.91147E-01 None 8.89401E-01 9.29377E-01 9.31221E-01 7.95893E-01 8.95827E-01
R/Q 3367 Ig-24 23 rs34819099 0.1029 -1.188 0.005 N 0.303 0.051 None gnomAD-2.1.1 1.00805E-02 None None None None N None 2.68387E-03 5.05222E-03 None 2.23809E-02 9.53145E-04 None 6.72851E-03 None 2.18932E-03 1.55964E-02 1.09358E-02
R/Q 3367 Ig-24 23 rs34819099 0.1029 -1.188 0.005 N 0.303 0.051 None gnomAD-3.1.2 9.615E-03 None None None None N None 3.0167E-03 6.02568E-03 1.75439E-02 1.92972E-02 5.7759E-04 None 3.01659E-03 9.49367E-03 1.57123E-02 7.66363E-03 9.09962E-03
R/Q 3367 Ig-24 23 rs34819099 0.1029 -1.188 0.005 N 0.303 0.051 None 1000 genomes 3.79393E-03 None None None None N None 0 2.9E-03 None None 1E-03 1.29E-02 None None None 3.1E-03 None
R/Q 3367 Ig-24 23 rs34819099 0.1029 -1.188 0.005 N 0.303 0.051 None gnomAD-4.0.0 1.47477E-02 None None None None N None 2.82531E-03 5.6822E-03 None 2.19888E-02 1.20332E-03 None 2.70211E-03 5.27879E-03 1.75878E-02 7.19148E-03 1.46711E-02
R/W 3367 Ig-24 23 rs762791706 0.3175 -0.793 0.984 D 0.607 0.391 0.42081714158 gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 5.44E-05 None 0 None 0 8.8E-06 0
R/W 3367 Ig-24 23 rs762791706 0.3175 -0.793 0.984 D 0.607 0.391 0.42081714158 gnomAD-4.0.0 2.46272E-05 None None None None N None 0 0 None 0 1.51179E-04 None 0 1.7337E-04 2.33826E-05 1.15934E-05 3.3117E-05
R/G 3487 Ig-25 23 rs547792470 0.6882 -1.446 None None None 0.25 None gnomAD-2.1.1 2.41E-05 None None None None I None 0 0 None 0 0 None 1.96117E-04 None 0 0 0
R/G 3487 Ig-25 23 rs547792470 0.6882 -1.446 None None None 0.25 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
R/G 3487 Ig-25 23 rs547792470 0.6882 -1.446 None None None 0.25 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
R/G 3487 Ig-25 23 rs547792470 0.6882 -1.446 None None None 0.25 None gnomAD-4.0.0 4.95719E-06 None None None None I None 0 0 None 0 0 None 0 0 0 7.68606E-05 1.60051E-05
R/K 3487 Ig-25 23 rs531271853 0.2001 -0.885 None None None 0.17 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/K 3487 Ig-25 23 rs531271853 0.2001 -0.885 None None None 0.17 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
R/K 3487 Ig-25 23 rs531271853 0.2001 -0.885 None None None 0.17 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
R/K 3487 Ig-25 23 rs531271853 0.2001 -0.885 None None None 0.17 None gnomAD-4.0.0 6.56823E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.07297E-04 0
R/S 3487 Ig-25 23 None 0.7894 None None None None 0.243 None gnomAD-4.0.0 1.59121E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
R/T 3487 Ig-25 23 rs531271853 0.5211 None None None None 0.198 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
R/T 3487 Ig-25 23 rs531271853 0.5211 None None None None 0.198 None gnomAD-4.0.0 6.57333E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.07125E-04 0
V/G 3682 Ig-26 23 rs2086971533 0.3507 None None None None 0.06 None gnomAD-4.0.0 6.84215E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-04 0
T/P 3960 Ig-28 23 rs1487929859 0.3797 -0.808 0.033 N 0.479 0.085 None gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/P 3960 Ig-28 23 rs1487929859 0.3797 -0.808 0.033 N 0.479 0.085 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/P 3960 Ig-28 23 rs1487929859 0.3797 -0.808 0.033 N 0.479 0.085 None gnomAD-4.0.0 2.56189E-06 None None None None I None 0 0 None 0 0 None 0 0 2.39273E-06 0 2.84398E-05
S/C 4628 Ig-29 23 None 0.1117 None None N 0.341 0.117 0.441324992753 gnomAD-4.0.0 6.8421E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9945E-07 0 0
S/F 4628 Ig-29 23 rs794729602 0.1647 -0.625 0.171 D 0.584 0.136 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 1.65948E-04
S/F 4628 Ig-29 23 rs794729602 0.1647 -0.625 0.171 D 0.584 0.136 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
S/F 4628 Ig-29 23 rs794729602 0.1647 -0.625 0.171 D 0.584 0.136 None gnomAD-4.0.0 2.10703E-05 None None None None N None 0 0 None 0 0 None 0 0 2.71229E-05 0 3.20256E-05
S/Y 4628 Ig-29 23 rs794729602 0.1501 None 0.093 D 0.575 0.168 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/Y 4628 Ig-29 23 rs794729602 0.1501 None 0.093 D 0.575 0.168 None gnomAD-4.0.0 1.85914E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54277E-06 0 0
E/K 4722 Ig-30 23 rs767604791 0.3914 -0.482 0.992 N 0.521 0.312 0.312306559268 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 4722 Ig-30 23 rs767604791 0.3914 -0.482 0.992 N 0.521 0.312 0.312306559268 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
T/I 4817 Ig-31 23 rs1299461448 0.2233 -0.087 0.669 N 0.481 0.34 0.436455679973 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 4817 Ig-31 23 rs1299461448 0.2233 -0.087 0.669 N 0.481 0.34 0.436455679973 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 4817 Ig-31 23 rs1299461448 0.2233 -0.087 0.669 N 0.481 0.34 0.436455679973 gnomAD-4.0.0 2.56314E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78819E-06 0 0
K/E 5004 Ig-33 24 None 0.4319 None 0.027 N 0.434 0.202 0.278968121808 gnomAD-4.0.0 1.59415E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86269E-06 0 0
E/G 5097 Ig-34 23 rs1230501060 0.5654 -1.425 0.999 D 0.731 0.575 0.655633844924 gnomAD-2.1.1 4.06E-06 None None None None I None 0 2.92E-05 None 0 0 None 0 None 0 0 0
E/G 5097 Ig-34 23 rs1230501060 0.5654 -1.425 0.999 D 0.731 0.575 0.655633844924 gnomAD-4.0.0 1.59678E-06 None None None None I None 0 2.29347E-05 None 0 0 None 0 0 0 0 0
A/S 5190 Ig-35 23 None 0.0938 None 0.201 N 0.517 0.126 0.373897652646 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/R 5283 Ig-36 23 None 0.1023 None 0.188 N 0.601 0.204 0.669087604336 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/T 5379 Ig-37 23 rs752346935 0.4948 -0.874 0.638 N 0.689 0.295 0.276065633971 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.35E-05 0
K/T 5379 Ig-37 23 rs752346935 0.4948 -0.874 0.638 N 0.689 0.295 0.276065633971 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
K/T 5379 Ig-37 23 rs752346935 0.4948 -0.874 0.638 N 0.689 0.295 0.276065633971 gnomAD-4.0.0 1.67356E-05 None None None None N None 0 0 None 0 0 None 0 0 2.28877E-05 0 0
T/I 5472 Ig-38 23 rs911246876 0.1148 None 0.062 N 0.522 0.171 0.348101942276 gnomAD-4.0.0 1.59357E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02792E-05
T/S 5472 Ig-38 23 rs911246876 0.0846 None 0.005 N 0.192 0.073 0.260249123532 gnomAD-4.0.0 1.59357E-06 None None None None N None 0 0 None 0 2.78133E-05 None 0 0 0 0 0
K/T 5566 Ig-39 24 None 0.1357 None None N 0.357 0.179 0.300784259202 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 5659 Ig-40 23 None 0.2616 None 0.896 D 0.469 0.144 0.21279746466 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
E/K 5659 Ig-40 23 rs763708860 0.1322 -0.756 0.811 N 0.519 0.275 0.32580497728 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/K 5659 Ig-40 23 rs763708860 0.1322 -0.756 0.811 N 0.519 0.275 0.32580497728 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 5659 Ig-40 23 rs763708860 0.1322 -0.756 0.811 N 0.519 0.275 0.32580497728 gnomAD-4.0.0 3.09866E-06 None None None None I None 4.00545E-05 0 None 0 0 None 0 0 1.69531E-06 0 0
T/A 5752 Ig-41 23 rs774619432 0.0743 -1.163 0.001 N 0.176 0.098 0.139678290688 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.78E-05 0
T/A 5752 Ig-41 23 rs774619432 0.0743 -1.163 0.001 N 0.176 0.098 0.139678290688 gnomAD-4.0.0 1.27373E-05 None None None None N None 0 0 None 0 0 None 0 0 8.57829E-06 7.16558E-05 0
T/I 5752 Ig-41 23 None 0.1029 None 0.002 N 0.341 0.203 0.314417295294 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
I/M 5941 Ig-43 23 rs372022675 0.1388 -0.859 0.976 N 0.517 0.243 None gnomAD-2.1.1 4.05E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
I/M 5941 Ig-43 23 rs372022675 0.1388 -0.859 0.976 N 0.517 0.243 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/M 5941 Ig-43 23 rs372022675 0.1388 -0.859 0.976 N 0.517 0.243 None gnomAD-4.0.0 6.08953E-06 None None None None N None 1.7466E-05 0 None 0 0 None 0 0 6.02472E-06 0 0
I/R 5941 Ig-43 23 rs773190186 0.3079 None 0.035 N 0.469 0.342 0.642757676758 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
I/R 5941 Ig-43 23 rs773190186 0.3079 None 0.035 N 0.469 0.342 0.642757676758 gnomAD-4.0.0 6.5716E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07125E-04 0
I/T 5941 Ig-43 23 rs773190186 0.2301 -1.554 0.959 N 0.476 0.341 0.649000688064 gnomAD-2.1.1 1.62E-05 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 1.8E-05 0
I/T 5941 Ig-43 23 rs773190186 0.2301 -1.554 0.959 N 0.476 0.341 0.649000688064 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/T 5941 Ig-43 23 rs773190186 0.2301 -1.554 0.959 N 0.476 0.341 0.649000688064 gnomAD-4.0.0 6.19762E-06 None None None None N None 0 5.00233E-05 None 0 0 None 1.56255E-05 0 2.54305E-06 1.0981E-05 3.20277E-05
I/V 5941 Ig-43 23 rs397517487 0.0987 -1.299 0.509 N 0.302 0.145 None gnomAD-2.1.1 3.95E-05 None None None None N None 2.06851E-04 1.13282E-04 None 0 0 None 0 None 0 7.9E-06 1.41044E-04
I/V 5941 Ig-43 23 rs397517487 0.0987 -1.299 0.509 N 0.302 0.145 None gnomAD-3.1.2 6.57E-05 None None None None N None 2.17119E-04 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 5941 Ig-43 23 rs397517487 0.0987 -1.299 0.509 N 0.302 0.145 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
I/V 5941 Ig-43 23 rs397517487 0.0987 -1.299 0.509 N 0.302 0.145 None gnomAD-4.0.0 1.92111E-05 None None None None N None 2.26564E-04 1.0001E-04 None 0 0 None 6.2498E-05 0 2.54307E-06 0 1.60077E-05
L/H 6034 Ig-44 23 None 0.1265 None 1.0 N 0.786 0.43 0.848622260122 gnomAD-4.0.0 6.8506E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1636E-05 0
L/P 6034 Ig-44 23 None 0.713 None 0.999 N 0.786 0.498 0.84006711756 gnomAD-4.0.0 6.8506E-07 None None None None N None 0 0 None 0 0 None 1.87631E-05 0 0 0 0
Q/R 6128 Ig-45 24 None 0.0942 None 0.012 N 0.327 0.258 0.143124449307 gnomAD-4.0.0 1.59179E-06 None None None None N None 0 0 None 0 2.77793E-05 None 0 0 0 0 0
E/D 6221 Ig-46 23 rs369544339 0.436 -1.044 0.92 D 0.405 0.115 0.24896430686 gnomAD-2.1.1 8.58E-05 None None None None I None 4.14E-05 2.83E-05 None 1.06507E-03 0 None 3.27E-05 None 0 6.26E-05 2.80978E-04
E/D 6221 Ig-46 23 rs369544339 0.436 -1.044 0.92 D 0.405 0.115 0.24896430686 gnomAD-3.1.2 1.05162E-04 None None None None I None 2.41E-05 6.55E-05 0 2.59815E-03 0 None 0 0 5.88E-05 2.07039E-04 0
E/D 6221 Ig-46 23 rs369544339 0.436 -1.044 0.92 D 0.405 0.115 0.24896430686 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
E/D 6221 Ig-46 23 rs369544339 0.436 -1.044 0.92 D 0.405 0.115 0.24896430686 gnomAD-4.0.0 1.11549E-04 None None None None I None 1.33305E-05 6.668E-05 None 1.6563E-03 0 None 0 0 9.15529E-05 4.39174E-05 2.24086E-04
E/G 6221 Ig-46 23 rs1365356147 0.4572 -1.39 0.959 N 0.552 0.355 0.527660502957 gnomAD-4.0.0 1.5917E-06 None None None None I None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
V/A 6407 Ig-48 23 rs747444832 0.1678 None 0.047 N 0.25 0.079 0.629781192331 gnomAD-4.0.0 7.52968E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89826E-06 0 0
K/E 6503 Ig-49 23 None 0.1626 None 0.338 N 0.48 0.234 0.258283824007 gnomAD-4.0.0 1.59321E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43373E-05 0
I/M 6596 Ig-50 23 rs2079617659 0.0816 None 0.108 D 0.421 0.059 0.231873229951 gnomAD-4.0.0 1.59302E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43559E-05 0
I/T 6596 Ig-50 23 None 0.0958 None None N 0.153 0.111 0.541285430251 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 6596 Ig-50 23 rs369108292 0.0575 -0.76 None N 0.085 0.08 None gnomAD-2.1.1 8.06E-06 None None None None N None 6.47E-05 2.9E-05 None 0 0 None 0 None 0 0 0
I/V 6596 Ig-50 23 rs369108292 0.0575 -0.76 None N 0.085 0.08 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
I/V 6596 Ig-50 23 rs369108292 0.0575 -0.76 None N 0.085 0.08 None gnomAD-4.0.0 4.34001E-06 None None None None N None 8.01196E-05 1.66767E-05 None 0 0 None 0 0 0 0 0
K/E 6690 Ig-51 24 None 0.2709 None 0.993 D 0.502 0.318 0.430694319191 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
E/V 6783 Ig-52 23 None 0.167 None 0.99 N 0.676 0.518 0.701518117412 gnomAD-4.0.0 1.37092E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.33187E-05 0
S/T 6876 Ig-53 23 rs1359024577 0.0555 -0.599 None N 0.134 0.101 0.0551355673512 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
S/T 6876 Ig-53 23 rs1359024577 0.0555 -0.599 None N 0.134 0.101 0.0551355673512 gnomAD-4.0.0 4.1089E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39967E-06 0 0
K/N 6970 Ig-54 23 rs2154303625 0.3898 None 0.549 N 0.535 0.139 0.149567049428 gnomAD-4.0.0 1.59249E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86044E-06 0 0
K/R 7066 Ig-55 23 rs553548392 0.0784 -0.625 0.032 N 0.346 0.105 None gnomAD-2.1.1 2.39978E-04 None None None None N None 0 1.87298E-03 None 0 0 None 0 None 0 0 1.41044E-04
K/R 7066 Ig-55 23 rs553548392 0.0784 -0.625 0.032 N 0.346 0.105 None gnomAD-3.1.2 1.31432E-04 None None None None N None 0 1.31027E-03 0 0 0 None 0 0 0 0 0
K/R 7066 Ig-55 23 rs553548392 0.0784 -0.625 0.032 N 0.346 0.105 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
K/R 7066 Ig-55 23 rs553548392 0.0784 -0.625 0.032 N 0.346 0.105 None gnomAD-4.0.0 1.28142E-04 None None None None N None 0 1.61093E-03 None 0 0 None 0 0 0 0 1.42215E-04
V/A 7159 Ig-56 23 rs749509937 0.221 -1.352 0.454 N 0.471 0.108 0.550589291799 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 6.63E-05 None 0 0 0
V/A 7159 Ig-56 23 rs749509937 0.221 -1.352 0.454 N 0.471 0.108 0.550589291799 gnomAD-4.0.0 6.84945E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.16507E-04 0
V/I 7159 Ig-56 23 rs371267140 0.0723 0.006 0.029 N 0.143 0.109 None gnomAD-2.1.1 3.96E-05 None None None None N None 1.6581E-04 5.71E-05 None 0 0 None 0 None 4.02E-05 3.15E-05 0
V/I 7159 Ig-56 23 rs371267140 0.0723 0.006 0.029 N 0.143 0.109 None gnomAD-3.1.2 8.55E-05 None None None None N None 1.93097E-04 1.30993E-04 0 0 0 None 9.41E-05 0 2.94E-05 0 0
V/I 7159 Ig-56 23 rs371267140 0.0723 0.006 0.029 N 0.143 0.109 None gnomAD-4.0.0 3.41186E-05 None None None None N None 2.40565E-04 1.00375E-04 None 0 2.23324E-05 None 3.12764E-05 0 1.95051E-05 1.10312E-05 6.41355E-05
T/I 7252 Ig-57 23 rs375714080 0.1573 -0.195 0.001 D 0.323 0.242 None gnomAD-4.0.0 1.0949E-05 None None None None N None 0 0 None 0 0 None 0 0 1.43927E-05 0 0
Q/R 7345 Ig-58 23 rs1224196588 0.1019 -0.165 0.642 N 0.395 0.153 0.220303561663 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.66E-05 0 0
Q/R 7345 Ig-58 23 rs1224196588 0.1019 -0.165 0.642 N 0.395 0.153 0.220303561663 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.41E-05 0 0 0 0
Q/R 7345 Ig-58 23 rs1224196588 0.1019 -0.165 0.642 N 0.395 0.153 0.220303561663 gnomAD-4.0.0 3.84653E-06 None None None None N None 0 0 None 0 0 None 4.71046E-05 0 0 0 0
R/G 7441 Ig-59 23 None 0.4051 None 0.999 N 0.668 0.515 0.684510456746 gnomAD-4.0.0 2.05309E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69898E-06 0 0
R/P 7441 Ig-59 23 None 0.8188 None 1.0 N 0.726 0.46 0.644673199507 gnomAD-4.0.0 6.84359E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99648E-07 0 0
R/Q 7441 Ig-59 23 rs774382033 0.1255 -0.402 1.0 N 0.661 0.291 0.280987212366 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 8.9E-06 0
R/Q 7441 Ig-59 23 rs774382033 0.1255 -0.402 1.0 N 0.661 0.291 0.280987212366 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
R/Q 7441 Ig-59 23 rs774382033 0.1255 -0.402 1.0 N 0.661 0.291 0.280987212366 gnomAD-4.0.0 5.57865E-06 None None None None N None 1.3359E-05 0 None 0 0 None 0 0 5.08669E-06 1.09839E-05 1.60143E-05
E/A 7724 Ig-62 23 rs750019682 0.1905 -0.688 0.755 D 0.522 0.349 0.39843156188 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/A 7724 Ig-62 23 rs750019682 0.1905 -0.688 0.755 D 0.522 0.349 0.39843156188 gnomAD-4.0.0 1.59243E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
R/G 8007 Ig-65 23 None 0.3112 None 0.362 D 0.512 0.305 0.504789117978 gnomAD-4.0.0 6.84211E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
R/P 8007 Ig-65 23 rs765789516 0.845 None 0.736 N 0.589 0.449 0.438064232554 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/P 8007 Ig-65 23 rs765789516 0.845 None 0.736 N 0.589 0.449 0.438064232554 gnomAD-4.0.0 6.57523E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
R/Q 8007 Ig-65 23 rs765789516 0.1033 -0.27 0.753 N 0.473 0.174 0.244539031024 gnomAD-2.1.1 9.65E-05 None None None None N None 0 5.8E-05 None 0 1.11321E-04 None 6.20956E-04 None 0 8.88E-06 0
R/Q 8007 Ig-65 23 rs765789516 0.1033 -0.27 0.753 N 0.473 0.174 0.244539031024 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
R/Q 8007 Ig-65 23 rs765789516 0.1033 -0.27 0.753 N 0.473 0.174 0.244539031024 gnomAD-4.0.0 4.95742E-05 None None None None N None 0 8.33278E-05 None 0 6.68837E-05 None 0 0 1.86482E-05 5.27009E-04 3.20123E-05
T/A 8193 Ig-67 23 rs774247592 0.1178 -1.495 0.454 N 0.433 0.144 0.369867359543 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
T/A 8193 Ig-67 23 rs774247592 0.1178 -1.495 0.454 N 0.433 0.144 0.369867359543 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.41E-05 0 0 0 0
T/A 8193 Ig-67 23 rs774247592 0.1178 -1.495 0.454 N 0.433 0.144 0.369867359543 gnomAD-4.0.0 1.02488E-05 None None None None N None 0 1.69451E-05 None 0 0 None 9.41413E-05 0 2.39316E-06 0 0
T/I 8193 Ig-67 23 None 0.2554 None 0.012 D 0.315 0.215 0.438170831126 gnomAD-4.0.0 1.59148E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85855E-06 0 0
K/E 8286 Ig-68 23 rs1454054276 0.1793 -0.78 0.114 N 0.456 0.158 0.236278675362 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/E 8286 Ig-68 23 rs1454054276 0.1793 -0.78 0.114 N 0.456 0.158 0.236278675362 gnomAD-4.0.0 3.50342E-05 None None None None N None 0 0 None 0 0 None 0 0 4.40793E-05 0 3.31543E-05
K/Q 8286 Ig-68 23 rs1454054276 0.1235 None None N 0.173 0.106 0.141422826196 gnomAD-4.0.0 1.37389E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.31543E-05
K/R 8286 Ig-68 23 None 0.0839 None 0.001 N 0.298 0.167 0.219573609325 gnomAD-4.0.0 6.86896E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99557E-07 0 0
R/C 8382 Ig-69 23 rs776519143 0.2821 -0.629 0.282 N 0.343 0.402 0.69279764771 gnomAD-2.1.1 6.07E-05 None None None None I None 0 8.73E-05 None 0 0 None 0 None 0 1.07724E-04 0
R/C 8382 Ig-69 23 rs776519143 0.2821 -0.629 0.282 N 0.343 0.402 0.69279764771 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/C 8382 Ig-69 23 rs776519143 0.2821 -0.629 0.282 N 0.343 0.402 0.69279764771 gnomAD-4.0.0 1.48784E-05 None None None None I None 1.33629E-05 6.67022E-05 None 0 0 None 1.56534E-05 0 1.44123E-05 1.09893E-05 0
R/H 8382 Ig-69 23 rs199598066 0.1212 -1.384 0.999 D 0.481 0.303 None gnomAD-2.1.1 2.15706E-04 None None None None I None 0 1.70474E-04 None 0 5.15E-05 None 0 None 4.01E-05 4.02399E-04 1.41764E-04
R/H 8382 Ig-69 23 rs199598066 0.1212 -1.384 0.999 D 0.481 0.303 None gnomAD-3.1.2 9.2E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 1.76439E-04 0 4.78469E-04
R/H 8382 Ig-69 23 rs199598066 0.1212 -1.384 0.999 D 0.481 0.303 None gnomAD-4.0.0 1.45686E-04 None None None None I None 1.33565E-05 1.8348E-04 None 0 2.23015E-05 None 1.40876E-04 0 1.75495E-04 0 9.61169E-05
R/S 8382 Ig-69 23 rs776519143 0.6164 None 0.921 N 0.366 0.319 0.475272412942 gnomAD-4.0.0 4.1067E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49822E-06 0 1.65739E-05
H/Q 8478 Ig-70 23 None 0.5468 None 0.993 N 0.531 0.23 0.218845423259 gnomAD-4.0.0 6.84279E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99557E-07 0 0
H/R 8478 Ig-70 23 rs747367057 0.1999 -0.865 0.949 N 0.502 0.247 0.250579442822 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/R 8478 Ig-70 23 rs747367057 0.1999 -0.865 0.949 N 0.502 0.247 0.250579442822 gnomAD-4.0.0 1.59165E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
E/G 8665 Ig-72 23 rs1226104343 0.5066 -1.425 0.932 N 0.663 0.392 0.518147779662 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
E/G 8665 Ig-72 23 rs1226104343 0.5066 -1.425 0.932 N 0.663 0.392 0.518147779662 gnomAD-4.0.0 1.91592E-05 None None None None N None 0 0 None 0 0 None 0 0 2.42875E-05 0 1.65651E-05
T/I 8852 Ig-74 23 rs777360482 0.0902 None None N 0.345 0.12 0.29132392195 gnomAD-4.0.0 6.8426E-07 None None None None N None 0 0 None 0 0 None 0 1.73491E-04 0 0 0
T/K 8852 Ig-74 23 rs777360482 0.1281 -0.575 None N 0.207 0.132 0.254761474806 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
T/K 8852 Ig-74 23 rs777360482 0.1281 -0.575 None N 0.207 0.132 0.254761474806 gnomAD-4.0.0 3.4213E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47858E-05 3.31378E-05
I/M 9041 Ig-76 23 rs890920556 0.082 None 0.11 N 0.243 0.03 0.369867359543 gnomAD-4.0.0 1.3689E-06 None None None None N None 5.97729E-05 0 None 0 0 None 0 0 0 0 0
I/V 9041 Ig-76 23 rs1395755933 0.0621 None 0.001 N 0.154 0.087 0.363356657567 gnomAD-4.0.0 4.10656E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39764E-06 0 0
T/I 9134 Ig-77 23 rs1023873134 0.0979 None 0.001 N 0.348 0.113 0.425970041486 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/I 9134 Ig-77 23 rs1023873134 0.0979 None 0.001 N 0.348 0.113 0.425970041486 gnomAD-4.0.0 8.05683E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01717E-05 0 1.60143E-05
T/R 9134 Ig-77 23 rs1023873134 0.1974 -0.262 0.484 N 0.641 0.226 0.508994031223 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/R 9134 Ig-77 23 rs1023873134 0.1974 -0.262 0.484 N 0.641 0.226 0.508994031223 gnomAD-4.0.0 6.84265E-07 None None None None N None 0 2.23734E-05 None 0 0 None 0 0 0 0 0
Q/H 9227 Ig-78 23 rs1214925721 0.2807 -1.168 0.998 N 0.499 0.377 0.156986980423 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
Q/H 9227 Ig-78 23 rs1214925721 0.2807 -1.168 0.998 N 0.499 0.377 0.156986980423 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
Q/P 9227 Ig-78 23 rs1262905911 0.6424 -0.129 0.998 N 0.576 0.476 0.530060385853 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
Q/P 9227 Ig-78 23 rs1262905911 0.6424 -0.129 0.998 N 0.576 0.476 0.530060385853 gnomAD-4.0.0 6.84199E-07 None None None None N None 0 0 None 0 2.51915E-05 None 0 0 0 0 0
Q/R 9227 Ig-78 23 rs1262905911 0.1395 None 0.068 N 0.291 0.153 0.18274738541 gnomAD-4.0.0 1.23156E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61903E-05 0 0
A/D 9323 Ig-79 23 rs2076615457 0.2028 None 0.055 None 0.607 0.174 0.42130639912 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/D 9323 Ig-79 23 rs2076615457 0.2028 None 0.055 None 0.607 0.174 0.42130639912 gnomAD-4.0.0 6.57419E-06 None None None None N None 2.41476E-05 0 None 0 0 None 0 0 0 0 0
A/T 9323 Ig-79 23 rs1313801373 0.0807 None None None 0.203 0.057 0.0611884634855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 9323 Ig-79 23 rs1313801373 0.0807 None None None 0.203 0.057 0.0611884634855 gnomAD-4.0.0 3.84383E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18006E-06 0 0
H/Q 9419 Ig-80 23 rs762212243 0.4223 -0.398 0.999 None 0.528 0.308 0.199424873507 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/Q 9419 Ig-80 23 rs762212243 0.4223 -0.398 0.999 None 0.528 0.308 0.199424873507 gnomAD-4.0.0 6.84175E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
R/C 9516 Ig-81 24 rs751958797 0.2624 -0.691 1.0 None 0.695 0.458 0.831489073666 gnomAD-2.1.1 2.85E-05 None None None None N None 4.13E-05 2.83E-05 None 0 0 None 1.30719E-04 None 0 1.56E-05 0
R/C 9516 Ig-81 24 rs751958797 0.2624 -0.691 1.0 None 0.695 0.458 0.831489073666 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 4.79386E-04
R/C 9516 Ig-81 24 rs751958797 0.2624 -0.691 1.0 None 0.695 0.458 0.831489073666 gnomAD-4.0.0 2.72679E-05 None None None None N None 0 1.66689E-05 None 0 0 None 0 0 2.45805E-05 1.20762E-04 4.80338E-05
R/H 9516 Ig-81 24 rs374156904 0.1602 -1.431 0.783 None 0.397 0.24 None gnomAD-2.1.1 3.99395E-04 None None None None N None 0 1.97997E-04 None 0 5.01741E-03 None 9.8E-05 None 0 0 5.60538E-04
R/H 9516 Ig-81 24 rs374156904 0.1602 -1.431 0.783 None 0.397 0.24 None gnomAD-3.1.2 2.23449E-04 None None None None N None 2.41E-05 1.96438E-04 0 0 5.39499E-03 None 0 0 1.47E-05 2.06868E-04 0
R/H 9516 Ig-81 24 rs374156904 0.1602 -1.431 0.783 None 0.397 0.24 None 1000 genomes 1.19808E-03 None None None None N None 0 0 None None 6E-03 0 None None None 0 None
R/H 9516 Ig-81 24 rs374156904 0.1602 -1.431 0.783 None 0.397 0.24 None gnomAD-4.0.0 2.54062E-04 None None None None N None 2.66581E-05 1.83297E-04 None 0 7.30968E-03 None 0 0 1.35616E-05 8.7831E-05 7.20184E-04
H/L 9612 Ig-82 23 rs779340510 0.2828 0.246 0.997 None 0.677 0.523 0.789046042334 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/L 9612 Ig-82 23 rs779340510 0.2828 0.246 0.997 None 0.677 0.523 0.789046042334 gnomAD-4.0.0 1.59106E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
H/Q 9612 Ig-82 23 None 0.3178 None 0.994 None 0.564 0.377 0.0884992946249 gnomAD-4.0.0 6.8417E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99431E-07 0 0
H/R 9612 Ig-82 23 rs779340510 0.1143 -0.617 0.135 None 0.398 0.325 0.28492961333 gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
H/R 9612 Ig-82 23 rs779340510 0.1143 -0.617 0.135 None 0.398 0.325 0.28492961333 gnomAD-4.0.0 3.18212E-06 None None None None N None 0 4.5731E-05 None 0 0 None 0 0 0 0 0
K/E 9720 Ig-83 23 rs780071353 0.6436 0.335 0.41 None 0.467 0.305 0.294561560033 gnomAD-2.1.1 8.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/E 9720 Ig-83 23 rs780071353 0.6436 0.335 0.41 None 0.467 0.305 0.294561560033 gnomAD-4.0.0 8.00869E-06 None None None None I None 0 0 None 0 0 None 0 0 1.44115E-05 0 0
D/H 9922 Ig-84 23 None 0.6779 None 0.896 None 0.541 0.319 0.342865806769 gnomAD-4.0.0 2.05623E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6998E-06 0 0
E/K 10100 Ig-86 23 rs748645732 0.8819 -1.044 0.999 None 0.601 0.393 0.385249989106 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
E/K 10100 Ig-86 23 rs748645732 0.8819 -1.044 0.999 None 0.601 0.393 0.385249989106 gnomAD-4.0.0 1.59086E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85747E-06 0 0
E/Q 13803 Ig-88 24 None 0.3356 None 1.0 N 0.626 0.29 0.15556083564 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.5189E-04 None 0 None 0 0 0
E/Q 13803 Ig-88 24 None 0.3356 None 1.0 N 0.626 0.29 0.15556083564 gnomAD-4.0.0 1.59369E-06 None None None None N None 0 0 None 0 2.7922E-05 None 0 0 0 0 0
D/N 13896 Ig-89 21 rs371312327 0.0934 -1.438 0.013 N 0.527 0.084 None gnomAD-2.1.1 4.49E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.01E-05 0
D/V 13896 Ig-89 21 None 0.131 None None N 0.454 0.104 0.207176502487 gnomAD-4.0.0 1.63394E-06 None None None None N None 0 0 None 0 0 None 0 0 2.93112E-06 0 0
E/A 13987 Ig-90 23 rs2060288635 0.5382 None 0.997 D 0.771 0.507 0.296679040009 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/A 13987 Ig-90 23 rs2060288635 0.5382 None 0.997 D 0.771 0.507 0.296679040009 gnomAD-4.0.0 6.57454E-06 None None None None N None 2.41255E-05 0 None 0 0 None 0 0 0 0 0
E/K 14164 Ig-92 23 rs1211763723 0.1601 None 0.998 D 0.489 0.38 0.455081427078 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/Q 14253 Ig-93 23 rs1276212237 0.3632 None 0.015 D 0.296 0.244 0.265010934533 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 14253 Ig-93 23 rs1276212237 0.3632 None 0.015 D 0.296 0.244 0.265010934533 gnomAD-4.0.0 2.56379E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78806E-06 0 0
E/G 14341 Ig-94 23 rs1307501867 0.5665 None 0.974 D 0.703 0.365 0.265010934533 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
E/D 14430 Ig-95 23 rs531051064 0.4965 -1.337 0.999 D 0.453 0.284 0.309839678437 gnomAD-2.1.1 6.46E-05 None None None None N None 0 0 None 0 8.92658E-04 None 0 None 0 0 0
E/D 14430 Ig-95 23 rs531051064 0.4965 -1.337 0.999 D 0.453 0.284 0.309839678437 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.8117E-04 None 0 0 0 0 0
E/D 14430 Ig-95 23 rs531051064 0.4965 -1.337 0.999 D 0.453 0.284 0.309839678437 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
E/D 14430 Ig-95 23 rs531051064 0.4965 -1.337 0.999 D 0.453 0.284 0.309839678437 gnomAD-4.0.0 1.85941E-05 None None None None N None 0 0 None 0 5.57886E-04 None 0 0 0 3.29417E-05 3.20215E-05
E/G 14430 Ig-95 23 None 0.5042 None 1.0 D 0.757 0.523 0.557207555769 gnomAD-4.0.0 1.59215E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
E/A 14519 Ig-96 23 rs1284272355 0.2505 -0.802 0.977 D 0.613 0.558 0.551798466036 gnomAD-2.1.1 4.25E-06 None None None None N None 0 0 None 0 0 None 3.46E-05 None 0 0 0
E/A 14519 Ig-96 23 rs1284272355 0.2505 -0.802 0.977 D 0.613 0.558 0.551798466036 gnomAD-4.0.0 1.61024E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.46126E-05 0
E/K 14697 Ig-98 23 rs1356852922 0.4733 -1.113 1.0 D 0.669 0.375 0.248417906384 gnomAD-2.1.1 1.07E-05 None None None None N None 4.13E-05 0 None 0 0 None 3.27E-05 None 0 7.81E-06 0
E/K 14697 Ig-98 23 rs1356852922 0.4733 -1.113 1.0 D 0.669 0.375 0.248417906384 gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 14697 Ig-98 23 rs1356852922 0.4733 -1.113 1.0 D 0.669 0.375 0.248417906384 gnomAD-4.0.0 1.41008E-05 None None None None N None 8.46167E-05 0 None 0 0 None 0 0 7.18343E-06 4.02134E-05 0
E/D 14786 Ig-99 22 rs1480354933 0.6574 -0.928 0.999 D 0.447 0.341 0.3085936734 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.68938E-04 None 0 None 0 0 0
E/D 14786 Ig-99 22 rs1480354933 0.6574 -0.928 0.999 D 0.447 0.341 0.3085936734 gnomAD-4.0.0 3.18642E-06 None None None None N None 0 0 None 0 5.57445E-05 None 0 0 0 0 0
E/K 14786 Ig-99 22 rs764555693 0.5509 -0.241 1.0 D 0.539 0.442 0.513560046879 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 1.78E-05 0
E/K 14786 Ig-99 22 rs764555693 0.5509 -0.241 1.0 D 0.539 0.442 0.513560046879 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 14786 Ig-99 22 rs764555693 0.5509 -0.241 1.0 D 0.539 0.442 0.513560046879 gnomAD-4.0.0 8.06041E-06 None None None None N None 0 0 None 0 2.23924E-05 None 0 0 6.78348E-06 4.39338E-05 0
E/D 14875 Ig-100 23 None 0.6311 None 0.999 D 0.461 0.274 0.28722502521 gnomAD-4.0.0 1.59385E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
E/D 14964 Ig-101 23 None 0.5196 None 0.999 D 0.442 0.285 0.393006254552 gnomAD-4.0.0 1.20041E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31261E-06 0 0
E/K 14964 Ig-101 23 rs1259780221 0.3174 None 0.999 N 0.549 0.423 0.47185959272 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.79846E-04
E/K 14964 Ig-101 23 rs1259780221 0.3174 None 0.999 N 0.549 0.423 0.47185959272 gnomAD-4.0.0 2.58483E-06 None None None None N None 0 0 None 0 0 None 0 0 2.41095E-06 0 2.87092E-05
E/Q 14964 Ig-101 23 rs1259780221 0.2004 -0.886 1.0 D 0.572 0.257 0.37550373646 gnomAD-2.1.1 4.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.70882E-04
E/Q 14964 Ig-101 23 rs1259780221 0.2004 -0.886 1.0 D 0.572 0.257 0.37550373646 gnomAD-4.0.0 1.60764E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.05362E-05
E/Q 15053 Ig-102 23 None 0.3552 None 1.0 N 0.576 0.405 0.37097340754 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
S/C 15142 Ig-103 23 None 0.1797 None 0.78 N 0.651 0.296 0.507987536778 gnomAD-4.0.0 1.36978E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79994E-06 0 0
S/F 15142 Ig-103 23 None 0.2706 None 0.484 D 0.705 0.375 0.658528444748 gnomAD-4.0.0 6.84888E-07 None None None None N None 2.99545E-05 0 None 0 0 None 0 0 0 0 0
E/G 15230 Ig-104 23 rs1209787066 0.6514 -1.61 1.0 D 0.747 0.603 0.607256217586 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/G 15230 Ig-104 23 rs1209787066 0.6514 -1.61 1.0 D 0.747 0.603 0.607256217586 gnomAD-4.0.0 3.1879E-06 None None None None N None 0 2.29263E-05 None 0 0 None 0 0 0 0 3.03122E-05
Q/R 15413 Ig-106 23 rs878864622 0.1119 None 0.704 N 0.505 0.308 None gnomAD-4.0.0 2.14504E-06 None None None None N None 0 0 None 0 0 None 0 0 2.77101E-06 0 0
E/K 15502 Ig-107 23 None 0.7984 None 0.999 D 0.499 0.389 0.536988229258 gnomAD-4.0.0 6.84809E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16028E-05 0
E/Q 15502 Ig-107 23 rs2057996369 0.4686 None 1.0 D 0.597 0.342 0.423597194605 gnomAD-4.0.0 6.84809E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00087E-07 0 0
T/I 16281 Ig-110 20 rs1553703631 0.2119 None 0.473 N 0.631 0.134 0.426670027402 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/I 16281 Ig-110 20 rs1553703631 0.2119 None 0.473 N 0.631 0.134 0.426670027402 gnomAD-4.0.0 6.58293E-06 None None None None N None 0 6.56254E-05 None 0 0 None 0 0 0 0 0
S/I 17270 Ig-112 20 rs200650668 0.0914 -0.081 None N 0.418 0.095 None gnomAD-2.1.1 4.0884E-04 None None None None N None 1.24141E-04 1.13366E-04 None 0 0 None 0 None 0 8.33766E-04 1.40964E-04
S/I 17270 Ig-112 20 rs200650668 0.0914 -0.081 None N 0.418 0.095 None gnomAD-3.1.2 4.54198E-04 None None None None N None 1.44907E-04 6.57E-05 0 0 0 None 0 0 8.9801E-04 0 4.78469E-04
S/I 17270 Ig-112 20 rs200650668 0.0914 -0.081 None N 0.418 0.095 None gnomAD-4.0.0 8.09272E-04 None None None None N None 1.33451E-04 1.00127E-04 None 0 0 None 1.56299E-05 0 1.07026E-03 0 4.16627E-04
S/R 17270 Ig-112 20 rs2055789793 0.3199 None 0.007 N 0.605 0.062 0.271763555656 gnomAD-4.0.0 1.3694E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79982E-06 0 0
V/G 17695 Ig-113 19 rs2055207996 0.2653 None 0.024 N 0.499 0.088 0.489938136499 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/G 17695 Ig-113 19 rs2055207996 0.2653 None 0.024 N 0.499 0.088 0.489938136499 gnomAD-4.0.0 6.5786E-06 None None None None I None 2.41278E-05 0 None 0 0 None 0 0 0 0 0
D/N 17989 Ig-114 22 rs1060500481 0.1648 None 0.322 N 0.393 0.171 0.223847106136 gnomAD-4.0.0 1.59521E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.03361E-05
D/Y 17989 Ig-114 22 None 0.3488 None 0.999 N 0.736 0.485 0.68628391497 gnomAD-4.0.0 1.59521E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86398E-06 0 0
K/E 18707 Ig-116 20 None 0.169 None 0.992 N 0.489 0.358 0.343788945184 gnomAD-4.0.0 1.59679E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86538E-06 0 0
K/T 18707 Ig-116 20 rs770068370 0.125 -0.864 0.999 D 0.7 0.511 0.447609009685 gnomAD-2.1.1 4.46E-05 None None None None I None 0 2.05653E-04 None 0 0 None 0 None 0 2.68E-05 1.67785E-04
K/T 18707 Ig-116 20 rs770068370 0.125 -0.864 0.999 D 0.7 0.511 0.447609009685 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
K/T 18707 Ig-116 20 rs770068370 0.125 -0.864 0.999 D 0.7 0.511 0.447609009685 gnomAD-4.0.0 1.79864E-05 None None None None I None 0 1.53249E-04 None 0 0 None 0 0 1.19899E-05 0 0
Y/C 19115 Ig-117 21 rs1479994671 0.6022 -0.394 1.0 N 0.731 0.494 0.742901043909 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
Y/C 19115 Ig-117 21 rs1479994671 0.6022 -0.394 1.0 N 0.731 0.494 0.742901043909 gnomAD-4.0.0 6.36951E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14394E-05 0 0
Y/H 19115 Ig-117 21 None 0.7325 None 1.0 N 0.653 0.49 0.601870671465 gnomAD-4.0.0 3.42207E-06 None None None None N None 0 0 None 0 0 None 0 0 4.4981E-06 0 0
R/C 19409 Ig-118 19 rs553606996 0.151 -0.286 0.999 N 0.721 0.405 0.826570024253 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
R/C 19409 Ig-118 19 rs553606996 0.151 -0.286 0.999 N 0.721 0.405 0.826570024253 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
R/C 19409 Ig-118 19 rs553606996 0.151 -0.286 0.999 N 0.721 0.405 0.826570024253 gnomAD-4.0.0 5.57866E-06 None None None None I None 0 3.33656E-05 None 3.37906E-05 4.47708E-05 None 0 0 2.54326E-06 1.0981E-05 0
R/H 19409 Ig-118 19 rs201505306 0.0862 -1.025 0.069 N 0.385 0.138 None gnomAD-2.1.1 2.71978E-04 None None None None I None 2.60417E-03 5.67E-05 None 0 5.18E-05 None 0 None 0 7.05E-05 1.40687E-04
R/H 19409 Ig-118 19 rs201505306 0.0862 -1.025 0.069 N 0.385 0.138 None gnomAD-3.1.2 6.90571E-04 None None None None I None 2.36498E-03 1.31096E-04 0 0 0 None 0 0 5.88E-05 0 4.80307E-04
R/H 19409 Ig-118 19 rs201505306 0.0862 -1.025 0.069 N 0.385 0.138 None gnomAD-4.0.0 1.32655E-04 None None None None I None 2.16288E-03 1.50175E-04 None 0 2.23724E-05 None 0 0 3.05187E-05 0 9.61076E-05
I/V 19809 Ig-119 20 rs754507241 0.0685 -0.05 None N 0.135 0.11 0.223146558224 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/V 19809 Ig-119 20 rs754507241 0.0685 -0.05 None N 0.135 0.11 0.223146558224 gnomAD-4.0.0 1.59192E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85945E-06 0 0
I/T 20101 Ig-120 22 rs777610858 0.4347 -1.128 0.98 N 0.636 0.265 0.73577268841 gnomAD-2.1.1 1.1E-05 None None None None I None 4.15E-05 2.92E-05 None 0 0 None 0 None 0 7.97E-06 0
I/T 20101 Ig-120 22 rs777610858 0.4347 -1.128 0.98 N 0.636 0.265 0.73577268841 gnomAD-3.1.2 1.32E-05 None None None None I None 0 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
I/T 20101 Ig-120 22 rs777610858 0.4347 -1.128 0.98 N 0.636 0.265 0.73577268841 gnomAD-4.0.0 1.92838E-05 None None None None I None 2.67845E-05 1.68759E-05 None 0 0 None 0 0 2.03886E-05 0 6.42963E-05
I/V 20101 Ig-120 22 rs2050170948 0.0887 None 0.689 N 0.417 0.169 None gnomAD-4.0.0 6.87031E-07 None None None None I None 0 0 None 0 0 None 0 0 9.01586E-07 0 0
R/Q 20499 Ig-121 21 rs201286988 0.1998 -0.212 0.844 N 0.536 0.22 None gnomAD-2.1.1 3.03E-05 None None None None N None 6.57E-05 3.11E-05 None 0 5.69E-05 None 0 None 0 3.77E-05 0
R/Q 20499 Ig-121 21 rs201286988 0.1998 -0.212 0.844 N 0.536 0.22 None gnomAD-4.0.0 3.11903E-05 None None None None N None 0 2.33318E-05 None 0 0 None 1.90078E-05 0 3.80906E-05 0 1.68011E-05
G/A 20792 Ig-122 24 None 0.0509 None 0.016 N 0.375 0.122 0.192905019026 gnomAD-4.0.0 6.84381E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99606E-07 0 0
G/E 20792 Ig-122 24 rs1223753533 0.1951 -1.587 0.946 N 0.795 0.272 0.516491959214 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 1.11844E-04 None 0 None 0 0 0
G/E 20792 Ig-122 24 rs1223753533 0.1951 -1.587 0.946 N 0.795 0.272 0.516491959214 gnomAD-4.0.0 2.05314E-06 None None None None N None 0 0 None 0 7.5704E-05 None 0 0 0 0 0
I/T 21197 Ig-123 21 rs1473107263 0.1525 None 0.002 N 0.24 0.088 0.59202398213 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 21197 Ig-123 21 rs1473107263 0.1525 None 0.002 N 0.24 0.088 0.59202398213 gnomAD-4.0.0 7.69578E-06 None None None None I None 0 0 None 0 0 None 0 0 1.19771E-05 0 2.84787E-05
I/V 21197 Ig-123 21 rs72646855 0.0687 -0.902 0.002 N 0.146 0.082 None gnomAD-2.1.1 6.05522E-04 None None None None I None 1.65494E-04 1.70174E-04 None 0 0 None 7.52322E-04 None 3.60808E-04 9.88359E-04 1.41203E-04
I/V 21197 Ig-123 21 rs72646855 0.0687 -0.902 0.002 N 0.146 0.082 None gnomAD-3.1.2 5.45866E-04 None None None None I None 2.65457E-04 1.96773E-04 0 0 0 None 1.88253E-04 0 9.70874E-04 2.06954E-04 0
I/V 21197 Ig-123 21 rs72646855 0.0687 -0.902 0.002 N 0.146 0.082 None gnomAD-4.0.0 7.41523E-04 None None None None I None 2.00048E-04 2.0018E-04 None 0 4.48009E-05 None 3.90747E-04 0 8.83527E-04 6.81154E-04 6.08623E-04
H/Q 21489 Ig-124 21 rs533088470 0.2571 0.234 0.794 N 0.435 0.209 0.442977140156 gnomAD-2.1.1 3.19E-05 None None None None N None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
H/Q 21489 Ig-124 21 rs533088470 0.2571 0.234 0.794 N 0.435 0.209 0.442977140156 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
H/Q 21489 Ig-124 21 rs533088470 0.2571 0.234 0.794 N 0.435 0.209 0.442977140156 gnomAD-4.0.0 6.5773E-06 None None None None N None 0 6.55308E-05 None 0 0 None 0 0 0 0 0
H/R 21489 Ig-124 21 None 0.1628 None 0.523 N 0.409 0.208 0.365317461125 gnomAD-4.0.0 1.5938E-06 None None None None N None 0 0 None 0 2.77546E-05 None 0 0 0 0 0
H/Y 21489 Ig-124 21 rs1412094100 0.1192 1.053 0.002 N 0.117 0.197 0.267755039894 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.57E-05 None 0 0 0
H/Y 21489 Ig-124 21 rs1412094100 0.1192 1.053 0.002 N 0.117 0.197 0.267755039894 gnomAD-4.0.0 6.84695E-06 None None None None N None 0 0 None 0 0 None 0 0 6.299E-06 2.32509E-05 1.6575E-05
P/L 22284 Ig-126 20 None 0.4094 None 0.797 N 0.691 0.352 0.700453235612 gnomAD-4.0.0 6.16186E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39901E-06 2.31992E-05 1.65854E-05
P/S 22284 Ig-126 20 None 0.4099 None 0.994 N 0.745 0.271 0.470155540985 gnomAD-4.0.0 1.36929E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31986E-05 0
P/T 22284 Ig-126 20 None 0.3094 None 0.988 N 0.717 0.27 0.487772906946 gnomAD-4.0.0 6.84644E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99821E-07 0 0
P/S 22573 Ig-127 14 rs767245563 0.3939 -0.375 1.0 D 0.749 0.385 0.482721949076 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 1.0012E-04 0 None 0 None 0 0 0
P/S 22573 Ig-127 14 rs767245563 0.3939 -0.375 1.0 D 0.749 0.385 0.482721949076 gnomAD-4.0.0 1.60013E-06 None None None None I None 0 0 None 4.78469E-05 0 None 0 0 0 0 0
S/G 22970 Ig-128 21 None 0.1218 None 0.994 N 0.525 0.212 0.18274738541 gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 3.66327E-05
P/L 23367 Ig-129 23 None 0.5497 None 0.999 N 0.776 0.421 0.852004672353 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 23656 Ig-130 20 rs368938701 0.4472 0.028 1.0 N 0.731 0.505 None gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.49E-05 0
P/L 23656 Ig-130 20 rs368938701 0.4472 0.028 1.0 N 0.731 0.505 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 23656 Ig-130 20 rs368938701 0.4472 0.028 1.0 N 0.731 0.505 None gnomAD-4.0.0 2.48057E-06 None None None None I None 0 0 None 0 0 None 0 0 3.39177E-06 0 0
D/N 24052 Ig-131 24 rs777857293 0.117 0.21 0.134 N 0.211 0.137 0.198526703765 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/N 24052 Ig-131 24 rs777857293 0.117 0.21 0.134 N 0.211 0.137 0.198526703765 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 24052 Ig-131 24 rs777857293 0.117 0.21 0.134 N 0.211 0.137 0.198526703765 gnomAD-4.0.0 2.56354E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78794E-06 0 0
D/V 24052 Ig-131 24 None 0.1807 None 0.988 N 0.572 0.447 0.695928707293 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/R 24451 Ig-132 21 None 0.6605 None 0.142 N 0.544 0.394 0.509878532422 gnomAD-4.0.0 1.59192E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02517E-05
P/L 24738 Ig-133 23 None 0.3761 None 0.994 N 0.765 0.455 0.837415841873 gnomAD-4.0.0 1.59246E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86005E-06 0 0
P/R 24738 Ig-133 23 None 0.5168 None 0.994 N 0.802 0.456 0.709956786332 gnomAD-4.0.0 1.59246E-06 None None None None N None 0 0 None 0 0 None 1.88374E-05 0 0 0 0
P/T 24738 Ig-133 23 None 0.3521 None 0.994 N 0.795 0.393 0.617781757779 gnomAD-4.0.0 1.59252E-06 None None None None N None 0 0 None 0 0 None 1.88395E-05 0 0 0 0
D/A 25134 Ig-134 24 rs746343685 0.2216 None 0.016 N 0.333 0.193 0.343788945184 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
D/A 25134 Ig-134 24 rs746343685 0.2216 None 0.016 N 0.333 0.193 0.343788945184 gnomAD-4.0.0 6.5754E-06 None None None None N None 0 6.55738E-05 None 0 0 None 0 0 0 0 0
D/G 25134 Ig-134 24 rs746343685 0.2598 -0.736 0.002 N 0.251 0.212 0.208816687407 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/G 25134 Ig-134 24 rs746343685 0.2598 -0.736 0.002 N 0.251 0.212 0.208816687407 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 25134 Ig-134 24 rs746343685 0.2598 -0.736 0.002 N 0.251 0.212 0.208816687407 gnomAD-4.0.0 2.56289E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78785E-06 0 0
D/H 25134 Ig-134 24 None 0.3463 None 0.896 N 0.561 0.283 0.298745278005 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
P/S 25533 Ig-135 20 rs1707347772 0.3013 None 1.0 D 0.78 0.426 0.448300063881 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
D/V 26216 Ig-137 24 None 0.4205 None 0.684 N 0.624 0.415 0.54038131941 gnomAD-4.0.0 1.5929E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86054E-06 0 0
P/A 26615 Ig-138 22 None 0.1491 None 0.958 D 0.613 0.414 0.386721274199 gnomAD-4.0.0 6.8426E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99526E-07 0 0
P/S 26615 Ig-138 22 None 0.2785 None 0.994 N 0.774 0.323 0.398581233421 gnomAD-4.0.0 1.36852E-06 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 0 0 1.65695E-05
P/L 26902 Ig-139 23 rs1287537055 0.2346 -0.22 0.035 N 0.576 0.31 0.488827753106 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
P/L 26902 Ig-139 23 rs1287537055 0.2346 -0.22 0.035 N 0.576 0.31 0.488827753106 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 26902 Ig-139 23 rs1287537055 0.2346 -0.22 0.035 N 0.576 0.31 0.488827753106 gnomAD-4.0.0 2.56393E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78808E-06 0 0
P/S 26902 Ig-139 23 rs1024262797 0.2583 -1.0 0.973 N 0.777 0.446 0.414539908741 gnomAD-2.1.1 7.15E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.56E-05 0
P/S 26902 Ig-139 23 rs1024262797 0.2583 -1.0 0.973 N 0.777 0.446 0.414539908741 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 26902 Ig-139 23 rs1024262797 0.2583 -1.0 0.973 N 0.777 0.446 0.414539908741 gnomAD-4.0.0 1.17778E-05 None None None None I None 1.33636E-05 0 None 0 0 None 0 0 1.2716E-05 0 4.80538E-05
D/A 27298 Ig-140 21 rs557375464 0.215 -0.445 1.0 N 0.753 0.479 0.52991035303 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/A 27298 Ig-140 21 rs557375464 0.215 -0.445 1.0 N 0.753 0.479 0.52991035303 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
D/A 27298 Ig-140 21 rs557375464 0.215 -0.445 1.0 N 0.753 0.479 0.52991035303 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
D/A 27298 Ig-140 21 rs557375464 0.215 -0.445 1.0 N 0.753 0.479 0.52991035303 gnomAD-4.0.0 6.56737E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.06954E-04 0
D/G 27298 Ig-140 21 None 0.2583 None 1.0 D 0.762 0.518 0.473378105536 gnomAD-4.0.0 1.59237E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
D/N 27298 Ig-140 21 rs200697681 0.1183 -0.832 1.0 D 0.673 0.411 None gnomAD-2.1.1 2.79264E-04 None None None None I None 8.27E-05 1.18792E-03 None 0 0 None 0 None 0 2.43084E-04 4.21585E-04
D/N 27298 Ig-140 21 rs200697681 0.1183 -0.832 1.0 D 0.673 0.411 None gnomAD-3.1.2 1.64344E-04 None None None None I None 9.65E-05 3.93339E-04 0 5.77367E-04 0 None 0 0 1.76419E-04 2.07125E-04 0
D/N 27298 Ig-140 21 rs200697681 0.1183 -0.832 1.0 D 0.673 0.411 None 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
D/N 27298 Ig-140 21 rs200697681 0.1183 -0.832 1.0 D 0.673 0.411 None gnomAD-4.0.0 1.59925E-04 None None None None I None 7.99659E-05 8.66753E-04 None 6.75813E-05 2.22916E-05 None 0 0 1.57657E-04 1.09796E-05 1.60056E-04
T/A 27698 Ig-141 23 None 0.0881 None 0.656 N 0.529 0.219 0.365703291355 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 27985 Ig-142 23 rs978568900 0.1789 None 0.988 N 0.781 0.5 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 27985 Ig-142 23 rs978568900 0.1789 None 0.988 N 0.781 0.5 None gnomAD-4.0.0 3.1001E-06 None None None None N None 2.67208E-05 0 None 0 0 None 0 0 2.54345E-06 0 0
P/Q 27985 Ig-142 23 None 0.3078 None 0.988 N 0.801 0.436 0.494769474416 gnomAD-4.0.0 6.84578E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99685E-07 0 0
P/S 27985 Ig-142 23 rs1362226750 0.2518 -1.615 0.988 N 0.734 0.44 0.472181857204 gnomAD-2.1.1 4.05E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
P/S 27985 Ig-142 23 rs1362226750 0.2518 -1.615 0.988 N 0.734 0.44 0.472181857204 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/S 27985 Ig-142 23 rs1362226750 0.2518 -1.615 0.988 N 0.734 0.44 0.472181857204 gnomAD-4.0.0 1.86011E-06 None None None None N None 4.00855E-05 0 None 0 0 None 0 0 0 0 0
D/H 28380 Ig-143 23 None 0.4451 None 0.997 N 0.685 0.418 0.402326594622 gnomAD-4.0.0 6.84193E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
D/N 28380 Ig-143 23 rs1703440197 0.1745 None 0.904 N 0.549 0.308 0.322510055762 gnomAD-4.0.0 6.84193E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
P/L 29067 Ig-145 23 rs878925055 0.1964 -0.211 1.0 N 0.735 0.474 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
P/L 29067 Ig-145 23 rs878925055 0.1964 -0.211 1.0 N 0.735 0.474 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
P/L 29067 Ig-145 23 rs878925055 0.1964 -0.211 1.0 N 0.735 0.474 None gnomAD-4.0.0 1.73514E-05 None None None None N None 2.66909E-05 0 None 0 0 None 0 0 2.11892E-05 0 1.60102E-05
P/L 30154 Ig-148 23 None 0.1759 None 1.0 N 0.721 0.434 0.756135564722 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/R 30154 Ig-148 23 None 0.2722 None 1.0 N 0.729 0.424 0.57058010678 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 30154 Ig-148 23 None 0.2131 None 1.0 N 0.762 0.366 0.477143196806 gnomAD-4.0.0 1.61884E-06 None None None None N None 0 0 None 0 2.79658E-05 None 0 0 0 0 0
L/V 30549 Ig-149 18 None 0.0745 None 0.027 N 0.476 0.072 0.246773566709 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
A/D 30948 Ig-150 22 None 0.6223 None 0.989 N 0.667 0.403 0.705984459088 gnomAD-4.0.0 2.05387E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79894E-06 0 1.65673E-05
A/V 30948 Ig-150 22 None 0.2363 None 0.961 N 0.478 0.273 0.611151671824 gnomAD-4.0.0 6.84625E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99471E-07 0 0
P/A 31238 Ig-151 21 rs779727282 0.2245 -0.769 0.928 N 0.647 0.397 0.509228182784 gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 0 None 2.61438E-04 None 0 0 0
P/A 31238 Ig-151 21 rs779727282 0.2245 -0.769 0.928 N 0.647 0.397 0.509228182784 gnomAD-4.0.0 1.43681E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-04 1.65656E-05
P/L 31238 Ig-151 21 None 0.2608 None 0.978 N 0.776 0.403 0.631849437455 gnomAD-4.0.0 1.36839E-06 None None None None N None 2.98757E-05 0 None 0 0 None 0 0 0 1.15934E-05 0
P/Q 31238 Ig-151 21 None 0.459 None 0.978 N 0.81 0.364 0.559006825661 gnomAD-4.0.0 6.84195E-07 None None None None N None 0 0 None 0 2.52118E-05 None 0 0 0 0 0
A/V 31638 Ig-152 18 rs1194896401 0.1086 -0.125 0.977 N 0.739 0.383 0.53754225682 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 1.78E-05 0
A/V 31638 Ig-152 18 rs1194896401 0.1086 -0.125 0.977 N 0.739 0.383 0.53754225682 gnomAD-4.0.0 6.84227E-06 None None None None N None 0 0 None 0 2.52054E-05 None 0 0 8.09539E-06 0 0
P/S 32329 Ig-154 23 rs759641873 0.2999 -1.437 1.0 N 0.768 0.399 None gnomAD-2.1.1 8.08E-06 None None None None N None 6.47E-05 0 None 0 0 None 3.27E-05 None 0 0 0
P/S 32329 Ig-154 23 rs759641873 0.2999 -1.437 1.0 N 0.768 0.399 None gnomAD-4.0.0 1.36842E-06 None None None None N None 2.98739E-05 0 None 0 0 None 0 0 0 1.15947E-05 0
P/T 32329 Ig-154 23 None 0.3225 None 1.0 N 0.762 0.402 0.429091045357 gnomAD-4.0.0 6.84211E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65645E-05
P/S 32727 Ig-155 20 None 0.3125 None 1.0 N 0.745 0.386 0.501559347837 gnomAD-4.0.0 6.84203E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99476E-07 0 0
P/T 32727 Ig-155 20 rs1276534291 0.3321 -0.253 1.0 N 0.737 0.409 0.512192450023 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
P/T 32727 Ig-155 20 rs1276534291 0.3321 -0.253 1.0 N 0.737 0.409 0.512192450023 gnomAD-4.0.0 6.84203E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99476E-07 0 0
M/I 33219 Ig-157 17 None 0.4292 None 0.001 N 0.227 0.18 0.425028116352 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79897E-06 0 0
M/R 33219 Ig-157 17 None 0.4831 None 0.099 N 0.445 0.288 0.535439087667 gnomAD-4.0.0 6.84242E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99484E-07 0 0
M/T 33219 Ig-157 17 rs1692183695 0.3685 None None N 0.171 0.241 0.639502115021 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
M/T 33219 Ig-157 17 rs1692183695 0.3685 None None N 0.171 0.241 0.639502115021 gnomAD-4.0.0 1.73516E-05 None None None None N None 0 0 None 0 6.01685E-04 None 0 0 8.4762E-07 0 0
K/R 33518 Ig-158 23 rs1691428129 0.172 None 0.997 N 0.424 0.45 0.415438038341 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/R 33518 Ig-158 23 rs1691428129 0.172 None 0.997 N 0.424 0.45 0.415438038341 gnomAD-4.0.0 5.12605E-06 None None None None N None 1.6909E-05 0 None 0 0 None 0 0 4.78755E-06 0 2.84527E-05
P/L 33618 Ig-159 23 rs748684753 0.9141 -0.115 1.0 D 0.739 0.528 0.831048749909 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/L 33618 Ig-159 23 rs748684753 0.9141 -0.115 1.0 D 0.739 0.528 0.831048749909 gnomAD-4.0.0 1.59187E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
P/S 33618 Ig-159 23 None 0.9045 None 1.0 N 0.754 0.398 0.487843537783 gnomAD-4.0.0 1.59197E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85863E-06 0 0
P/T 33618 Ig-159 23 None 0.9287 None 1.0 N 0.747 0.44 0.618635891131 gnomAD-4.0.0 1.59197E-06 None None None None N None 0 0 None 0 0 None 1.89065E-05 0 0 0 0
T/I 34280 Ig-161 23 rs886042505 0.8117 -0.198 1.0 D 0.751 0.532 0.613626781881 gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
T/I 34280 Ig-161 23 rs886042505 0.8117 -0.198 1.0 D 0.751 0.532 0.613626781881 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
T/I 34280 Ig-161 23 rs886042505 0.8117 -0.198 1.0 D 0.751 0.532 0.613626781881 gnomAD-4.0.0 3.84252E-06 None None None None N None 0 5.08302E-05 None 0 0 None 0 0 0 0 0
R/I 34385 Ig-162 23 rs1369995123 0.9402 -0.49 0.999 D 0.726 0.514 0.73428325888 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/K 34964 Ig-163 23 None 0.9671 None 1.0 N 0.673 0.276 0.112648838833 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
N/S 34964 Ig-163 23 rs769356385 0.3589 -1.017 0.999 N 0.538 0.37 0.254761474806 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
N/S 34964 Ig-163 23 rs769356385 0.3589 -1.017 0.999 N 0.538 0.37 0.254761474806 gnomAD-4.0.0 2.05242E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6982E-06 0 0
N/Y 34964 Ig-163 23 rs779363624 0.771 -0.293 1.0 N 0.782 0.582 0.698813973971 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 1.66889E-04 None 0 None 0 0 0
N/Y 34964 Ig-163 23 rs779363624 0.771 -0.293 1.0 N 0.782 0.582 0.698813973971 gnomAD-4.0.0 7.95444E-06 None None None None N None 0 0 None 0 1.38619E-04 None 0 0 0 0 0
V/M 35306 Ig-165 21 rs1434315858 0.0888 None 0.074 N 0.535 0.075 0.523546030903 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
V/M 35306 Ig-165 21 rs1434315858 0.0888 None 0.074 N 0.535 0.075 0.523546030903 gnomAD-4.0.0 1.97135E-05 None None None None N None 7.23973E-05 0 None 0 0 None 0 0 0 0 0
K/E 35442 Ig-166 23 None 0.1951 None 0.001 N 0.202 0.171 0.134241683229 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/R 35442 Ig-166 23 rs1688520726 0.1087 None 0.192 N 0.428 0.087 0.223847106136 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 35629 Ig-167 23 rs781094190 0.0863 -0.062 0.001 N 0.108 0.078 0.0986583533028 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 8.86E-06 0
N/S 35629 Ig-167 23 rs781094190 0.0863 -0.062 0.001 N 0.108 0.078 0.0986583533028 gnomAD-4.0.0 9.57799E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69819E-06 1.27524E-04 0
E/D 35724 Ig-168 23 None 0.3685 None 0.998 N 0.417 0.205 0.358540694251 gnomAD-4.0.0 6.84635E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16168E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.