Structural position:

  • Domain Type: Fn3
  • Aligned Position: 117
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/A 15740 Fn3-1 84 rs1409834543 0.0827 -0.753 0.005 N 0.221 0.073 0.154104182512 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.8E-05 None 0 0 0
T/A 15740 Fn3-1 84 rs1409834543 0.0827 -0.753 0.005 N 0.221 0.073 0.154104182512 gnomAD-4.0.0 4.10736E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.95862E-05 0
T/I 15740 Fn3-1 84 rs1184522966 0.1402 -0.249 0.934 N 0.596 0.195 0.31291088546 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
T/I 15740 Fn3-1 84 rs1184522966 0.1402 -0.249 0.934 N 0.596 0.195 0.31291088546 gnomAD-4.0.0 4.77952E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.30021E-05 0
T/S 15740 Fn3-1 84 None 0.127 None 0.062 N 0.223 0.052 0.16115917748 gnomAD-4.0.0 6.8456E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99857E-07 0 0
V/I 15841 Fn3-2 84 None 0.0706 None 0.001 N 0.275 0.058 0.146414634003 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/R 16137 Fn3-4 83 rs982994931 0.2899 -0.135 0.998 N 0.811 0.419 0.461759001683 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/R 16137 Fn3-4 83 rs982994931 0.2899 -0.135 0.998 N 0.811 0.419 0.461759001683 gnomAD-4.0.0 1.59387E-06 None None None None N None 0 2.28781E-05 None 0 0 None 0 0 0 0 0
P/S 16137 Fn3-4 83 rs879009898 0.1787 None 0.978 N 0.697 0.337 0.273938319068 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 16137 Fn3-4 83 rs879009898 0.1787 None 0.978 N 0.697 0.337 0.273938319068 gnomAD-4.0.0 1.17846E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61158E-05 0 0
A/S 16237 Fn3-5 83 None 0.1073 None 0.505 N 0.669 0.099 0.215109475489 gnomAD-4.0.0 1.67126E-06 None None None None N None 0 0 None 0 0 None 0 0 2.99846E-06 0 0
V/A 16433 Fn3-6 83 None 0.2681 None 0.822 N 0.599 0.214 0.569670436194 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
P/S 16533 Fn3-7 84 rs756975730 0.3978 -1.406 0.817 N 0.432 0.224 0.17948927462 gnomAD-2.1.1 4.04E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
P/S 16533 Fn3-7 84 rs756975730 0.3978 -1.406 0.817 N 0.432 0.224 0.17948927462 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
P/S 16533 Fn3-7 84 rs756975730 0.3978 -1.406 0.817 N 0.432 0.224 0.17948927462 gnomAD-4.0.0 5.58499E-06 None None None None N None 2.6753E-05 0 None 0 2.24215E-05 None 0 1.64853E-04 4.24137E-06 0 0
E/K 16633 Fn3-8 83 None 0.4782 None 0.939 N 0.726 0.232 0.341226946553 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
G/E 17129 Fn3-12 83 rs1372930722 0.4098 None 1.0 N 0.771 0.503 0.332646915603 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.94932E-04 None 0 0 0 0 0
G/E 17129 Fn3-12 83 rs1372930722 0.4098 None 1.0 N 0.771 0.503 0.332646915603 gnomAD-4.0.0 3.10016E-06 None None None None I None 0 0 None 0 2.23754E-05 None 0 0 2.54383E-06 0 1.60226E-05
I/V 17230 Fn3-13 84 None 0.0637 None 0.002 N 0.207 0.067 0.241664281697 gnomAD-4.0.0 1.59666E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87031E-06 0 0
P/S 17453 Fn3-14 85 None 0.1619 None 0.521 N 0.515 0.084 0.215869574891 gnomAD-4.0.0 1.59554E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.03177E-05
E/A 17652 Fn3-16 84 None 0.1511 None 0.999 N 0.717 0.329 0.306695030598 gnomAD-4.0.0 1.59287E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86121E-06 0 0
E/D 17652 Fn3-16 84 rs1325497507 0.3086 -0.223 0.999 N 0.597 0.112 0.199424873507 gnomAD-2.1.1 8.05E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
E/D 17652 Fn3-16 84 rs1325497507 0.3086 -0.223 0.999 N 0.597 0.112 0.199424873507 gnomAD-4.0.0 3.18571E-06 None None None None I None 0 4.57519E-05 None 0 0 None 0 0 0 0 0
E/K 17652 Fn3-16 84 None 0.1374 None 0.999 N 0.711 0.264 0.289098819767 gnomAD-4.0.0 3.18571E-06 None None None None I None 0 0 None 0 0 None 1.88239E-05 0 0 1.43308E-05 0
C/Y 17845 Fn3-17 82 None 0.3229 None 0.975 N 0.585 0.254 0.468669884856 gnomAD-4.0.0 1.5954E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86375E-06 0 0
E/D 17945 Fn3-18 84 rs556413709 0.1961 -0.411 0.996 N 0.606 0.135 0.240491677333 gnomAD-2.1.1 2.83E-05 None None None None I None 0 0 None 0 3.93479E-04 None 0 None 0 0 0
E/D 17945 Fn3-18 84 rs556413709 0.1961 -0.411 0.996 N 0.606 0.135 0.240491677333 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.94932E-04 None 0 0 0 0 0
E/D 17945 Fn3-18 84 rs556413709 0.1961 -0.411 0.996 N 0.606 0.135 0.240491677333 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
E/D 17945 Fn3-18 84 rs556413709 0.1961 -0.411 0.996 N 0.606 0.135 0.240491677333 gnomAD-4.0.0 4.34399E-06 None None None None I None 0 0 None 0 1.56754E-04 None 0 0 0 0 0
I/N 18149 Fn3-19 85 None 0.2009 None 0.055 N 0.599 0.121 0.342400092842 gnomAD-4.0.0 1.65667E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.52073E-05 0
I/V 18149 Fn3-19 85 None 0.0653 None 0.005 N 0.267 0.056 0.349429436713 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
I/F 18254 Fn3-20 89 rs766737617 0.2486 -1.539 0.638 N 0.774 0.07 0.336400405673 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
I/F 18254 Fn3-20 89 rs766737617 0.2486 -1.539 0.638 N 0.774 0.07 0.336400405673 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/F 18254 Fn3-20 89 rs766737617 0.2486 -1.539 0.638 N 0.774 0.07 0.336400405673 gnomAD-4.0.0 1.36479E-05 None None None None I None 0 0 None 0 0 None 0 0 1.78161E-05 1.09953E-05 0
I/T 18254 Fn3-20 89 rs1356331923 0.1284 -1.892 0.201 N 0.718 0.134 0.432604763906 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/T 18254 Fn3-20 89 rs1356331923 0.1284 -1.892 0.201 N 0.718 0.134 0.432604763906 gnomAD-4.0.0 3.42479E-06 None None None None I None 0 0 None 0 0 None 0 0 3.60125E-06 0 1.65893E-05
I/V 18561 Fn3-22 83 rs1327467989 0.0545 -1.127 None N 0.204 0.036 0.132336055621 gnomAD-2.1.1 4.09E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
I/V 18561 Fn3-22 83 rs1327467989 0.0545 -1.127 None N 0.204 0.036 0.132336055621 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 18561 Fn3-22 83 rs1327467989 0.0545 -1.127 None N 0.204 0.036 0.132336055621 gnomAD-4.0.0 6.57696E-06 None None None None I None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
I/F 18867 Fn3-24 84 None 0.1858 None 0.497 N 0.625 0.19 0.338834610459 gnomAD-4.0.0 1.89446E-06 None None None None N None 0 0 None 0 2.88984E-05 None 0 0 0 0 0
I/T 18867 Fn3-24 84 rs1178126114 0.0801 -0.865 0.124 N 0.573 0.216 0.515490261806 gnomAD-2.1.1 5.75E-06 None None None None N None 0 0 None 0 6.75E-05 None 0 None 0 0 0
I/T 18867 Fn3-24 84 rs1178126114 0.0801 -0.865 0.124 N 0.573 0.216 0.515490261806 gnomAD-4.0.0 1.89454E-06 None None None None N None 0 0 None 0 2.8885E-05 None 0 0 0 0 0
I/T 19071 Fn3-26 84 rs200001206 0.0715 -1.278 0.062 N 0.536 0.123 None gnomAD-2.1.1 3.28508E-04 None None None None I None 1.65371E-04 8.5E-05 None 0 0 None 0 None 7.59575E-04 5.07186E-04 1.40528E-04
I/T 19071 Fn3-26 84 rs200001206 0.0715 -1.278 0.062 N 0.536 0.123 None gnomAD-3.1.2 3.4184E-04 None None None None I None 2.17119E-04 0 0 0 0 None 5.65185E-04 0 5.4407E-04 0 0
I/T 19071 Fn3-26 84 rs200001206 0.0715 -1.278 0.062 N 0.536 0.123 None gnomAD-4.0.0 3.94811E-04 None None None None I None 1.59936E-04 3.33489E-05 None 0 0 None 8.74836E-04 0 4.71344E-04 0 1.76107E-04
M/V 19266 Fn3-27 84 rs372963343 0.0924 -0.275 0.002 N 0.261 0.206 None gnomAD-2.1.1 4.11E-05 None None None None I None 0 0 None 0 0 None 3.26397E-04 None 0 1.07E-05 0
M/V 19266 Fn3-27 84 rs372963343 0.0924 -0.275 0.002 N 0.261 0.206 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07125E-04 0
M/V 19266 Fn3-27 84 rs372963343 0.0924 -0.275 0.002 N 0.261 0.206 None gnomAD-4.0.0 2.03583E-05 None None None None I None 0 0 None 0 0 None 0 3.33111E-04 4.32231E-06 2.80171E-04 1.63999E-05
I/L 19562 Fn3-29 84 rs397517637 0.1718 -1.113 0.031 N 0.267 0.121 0.44318313171 gnomAD-2.1.1 7.18E-06 None None None None I None 8.28E-05 0 None 0 0 None 0 None 0 0 0
I/L 19562 Fn3-29 84 rs397517637 0.1718 -1.113 0.031 N 0.267 0.121 0.44318313171 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 19562 Fn3-29 84 rs397517637 0.1718 -1.113 0.031 N 0.267 0.121 0.44318313171 gnomAD-4.0.0 6.57272E-06 None None None None I None 2.41161E-05 0 None 0 0 None 0 0 0 0 0
I/R 19562 Fn3-29 84 None 0.3825 None 0.879 N 0.82 0.374 0.67247961064 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
I/V 19562 Fn3-29 84 rs397517637 0.1012 None 0.001 N 0.223 0.115 0.384919354899 gnomAD-4.0.0 6.00164E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25002E-06 0 3.66327E-05
I/T 19662 Fn3-30 84 None 0.0896 None 0.324 N 0.481 0.139 0.460795861206 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
I/V 19662 Fn3-30 84 rs886055259 0.0661 None None N 0.193 0.072 0.251639045875 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.93949E-04 None 0 0 0 0 0
I/V 19662 Fn3-30 84 rs886055259 0.0661 None None N 0.193 0.072 0.251639045875 gnomAD-4.0.0 1.79432E-05 None None None None I None 0 0 None 0 3.40351E-04 None 0 0 0 0 0
E/V 19765 Fn3-31 86 rs766141647 0.1387 -0.131 1.0 N 0.819 0.429 0.557481709393 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 1.65837E-04
E/V 19765 Fn3-31 86 rs766141647 0.1387 -0.131 1.0 N 0.819 0.429 0.557481709393 gnomAD-4.0.0 8.21192E-06 None None None None I None 0 0 None 0 0 None 0 0 0 8.11707E-05 8.28555E-05
R/C 19959 Fn3-32 83 rs564432498 0.2112 -0.306 1.0 N 0.774 0.377 0.581818759506 gnomAD-2.1.1 1.97652E-04 None None None None I None 0 5.82E-05 None 0 0 None 1.47136E-03 None 0 8.91E-06 1.66445E-04
R/C 19959 Fn3-32 83 rs564432498 0.2112 -0.306 1.0 N 0.774 0.377 0.581818759506 gnomAD-3.1.2 6.58E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 1.86722E-03 0
R/C 19959 Fn3-32 83 rs564432498 0.2112 -0.306 1.0 N 0.774 0.377 0.581818759506 1000 genomes 1.19808E-03 None None None None I None 0 0 None None 0 0 None None None 6.1E-03 None
R/C 19959 Fn3-32 83 rs564432498 0.2112 -0.306 1.0 N 0.774 0.377 0.581818759506 gnomAD-4.0.0 9.85676E-05 None None None None I None 0 1.66856E-05 None 0 0 None 1.56333E-05 0 6.78245E-06 1.55975E-03 1.12108E-04
R/H 19959 Fn3-32 83 rs748120315 0.178 -0.887 1.0 N 0.791 0.436 0.399159426805 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 1.78E-05 0
R/H 19959 Fn3-32 83 rs748120315 0.178 -0.887 1.0 N 0.791 0.436 0.399159426805 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 19959 Fn3-32 83 rs748120315 0.178 -0.887 1.0 N 0.791 0.436 0.399159426805 gnomAD-4.0.0 2.66566E-05 None None None None I None 0 1.66872E-05 None 0 2.24024E-05 None 0 0 3.13687E-05 2.19674E-05 3.20297E-05
R/S 19959 Fn3-32 83 rs564432498 0.7244 None 1.0 N 0.705 0.307 0.341226946553 gnomAD-4.0.0 6.84504E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99656E-07 0 0
L/F 20058 Fn3-33 82 rs2050227759 0.171 None 1.0 N 0.786 0.286 0.473774312618 gnomAD-4.0.0 1.59194E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85977E-06 0 0
E/D 20455 Fn3-36 85 rs1347430347 0.2935 None 0.104 N 0.263 0.044 0.156986980423 gnomAD-2.1.1 3.19E-05 None None None None I None 0 1.18203E-03 None 0 0 None 0 None 0 0 0
E/D 20455 Fn3-36 85 rs1347430347 0.2935 None 0.104 N 0.263 0.044 0.156986980423 gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
E/D 20455 Fn3-36 85 rs1347430347 0.2935 None 0.104 N 0.263 0.044 0.156986980423 gnomAD-4.0.0 2.63054E-05 None None None None I None 9.65251E-05 0 None 0 0 None 0 0 0 0 0
E/V 20455 Fn3-36 85 None 0.2597 None 0.999 N 0.819 0.372 0.353761421236 gnomAD-4.0.0 7.01211E-07 None None None None I None 0 0 None 0 0 None 0 0 9.13232E-07 0 0
V/I 20650 Fn3-37 82 rs373298871 0.0889 -0.587 0.27 N 0.471 0.15 None gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/I 20650 Fn3-37 82 rs373298871 0.0889 -0.587 0.27 N 0.471 0.15 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 20650 Fn3-37 82 rs373298871 0.0889 -0.587 0.27 N 0.471 0.15 None gnomAD-4.0.0 5.57814E-06 None None None None I None 0 0 None 0 0 None 0 0 6.7818E-06 0 1.60133E-05
I/T 21046 Fn3-40 84 rs368868562 0.0877 -1.51 0.175 N 0.507 0.222 None gnomAD-2.1.1 5.07E-05 None None None None N None 5.07743E-04 0 None 0 0 None 0 None 0 0 0
I/T 21046 Fn3-40 84 rs368868562 0.0877 -1.51 0.175 N 0.507 0.222 None gnomAD-3.1.2 6.58E-05 None None None None N None 2.41324E-04 0 0 0 0 None 0 0 0 0 0
I/T 21046 Fn3-40 84 rs368868562 0.0877 -1.51 0.175 N 0.507 0.222 None gnomAD-4.0.0 1.28462E-05 None None None None N None 2.1913E-04 1.92626E-05 None 0 0 None 0 0 1.73382E-06 0 1.66656E-05
I/T 21153 Fn3-41 90 rs772411127 0.1576 -0.712 0.784 N 0.499 0.163 None gnomAD-2.1.1 4.38E-05 None None None None I None 0 0 None 0 0 None 6.63E-05 None 0 8.01E-05 0
I/T 21153 Fn3-41 90 rs772411127 0.1576 -0.712 0.784 N 0.499 0.163 None gnomAD-3.1.2 3.29E-05 None None None None I None 0 0 0 0 0 None 0 0 7.36E-05 0 0
I/T 21153 Fn3-41 90 rs772411127 0.1576 -0.712 0.784 N 0.499 0.163 None gnomAD-4.0.0 1.86321E-05 None None None None I None 1.33633E-05 0 None 0 0 None 0 0 2.12215E-05 4.41199E-05 0
P/S 21348 Fn3-42 83 rs1453250932 0.1369 None 0.003 N 0.3 0.075 0.185906805712 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 21348 Fn3-42 83 rs1453250932 0.1369 None 0.003 N 0.3 0.075 0.185906805712 gnomAD-4.0.0 1.23987E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69573E-06 0 0
P/T 21348 Fn3-42 83 None 0.098 None 0.101 N 0.466 0.065 0.218112801441 gnomAD-4.0.0 1.36879E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31906E-05 0
V/A 21449 Fn3-43 84 rs748888420 0.2261 -1.712 0.91 N 0.575 0.103 0.505640481493 gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.35E-05 0
V/A 21449 Fn3-43 84 rs748888420 0.2261 -1.712 0.91 N 0.575 0.103 0.505640481493 gnomAD-3.1.2 1.98E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/A 21449 Fn3-43 84 rs748888420 0.2261 -1.712 0.91 N 0.575 0.103 0.505640481493 gnomAD-4.0.0 6.4118E-06 None None None None I None 0 0 None 0 0 None 0 0 9.58102E-06 0 2.84657E-05
V/I 21449 Fn3-43 84 rs2049029716 0.0699 None 0.248 N 0.309 0.053 0.323615622048 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 21449 Fn3-43 84 rs2049029716 0.0699 None 0.248 N 0.309 0.053 0.323615622048 gnomAD-4.0.0 2.03005E-06 None None None None I None 0 6.15612E-05 None 0 0 None 0 0 1.20497E-06 0 0
I/T 21842 Fn3-46 86 None 0.3157 None 0.061 N 0.378 0.165 0.50557994651 gnomAD-4.0.0 1.36998E-06 None None None None I None 0 0 None 0 2.53575E-05 None 0 0 0 0 1.6592E-05
P/S 22138 Fn3-48 84 rs759290401 0.1331 -0.736 0.946 N 0.717 0.256 0.286848849266 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
P/S 22138 Fn3-48 84 rs759290401 0.1331 -0.736 0.946 N 0.717 0.256 0.286848849266 gnomAD-4.0.0 1.59249E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86035E-06 0 0
Y/C 22240 Fn3-49 85 rs745376985 0.2007 -0.537 0.994 N 0.621 0.341 0.381916209588 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
Y/C 22240 Fn3-49 85 rs745376985 0.2007 -0.537 0.994 N 0.621 0.341 0.381916209588 gnomAD-4.0.0 1.37016E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.16066E-05 1.65959E-05
Y/N 22240 Fn3-49 85 None 0.3709 None 0.884 N 0.627 0.334 0.500678981321 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
I/T 22436 Fn3-50 83 rs777418071 0.1803 -1.278 0.892 N 0.686 0.244 0.584551062954 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 1.78E-05 0
I/T 22436 Fn3-50 83 rs777418071 0.1803 -1.278 0.892 N 0.686 0.244 0.584551062954 gnomAD-4.0.0 1.23195E-05 None None None None I None 0 0 None 0 0 None 0 0 1.34951E-05 3.47858E-05 0
I/V 22436 Fn3-50 83 None 0.0868 None 0.011 N 0.247 0.116 0.255270683199 gnomAD-4.0.0 1.59233E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8602E-06 0 0
E/D 22531 Fn3-51 81 None 0.1968 None 0.891 N 0.434 0.139 0.284150004643 gnomAD-4.0.0 6.84367E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99651E-07 0 0
E/V 22531 Fn3-51 81 None 0.1149 None 0.801 N 0.605 0.155 0.334659703779 gnomAD-4.0.0 6.84363E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99649E-07 0 0
V/I 22726 Fn3-52 84 rs1553620392 0.0754 None 0.046 N 0.24 0.05 0.340992353424 gnomAD-4.0.0 1.59279E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86126E-06 0 0
V/M 22826 Fn3-53 84 rs1399440525 0.1408 -0.592 0.968 N 0.705 0.131 0.382087116544 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/M 22826 Fn3-53 84 rs1399440525 0.1408 -0.592 0.968 N 0.705 0.131 0.382087116544 gnomAD-4.0.0 1.36889E-06 None None None None I None 0 4.47287E-05 None 0 0 None 0 0 0 0 0
I/V 22925 Fn3-54 85 None 0.0722 None 0.025 N 0.292 0.087 0.463843524616 gnomAD-4.0.0 1.59295E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43451E-05 0
I/L 23222 Fn3-56 84 None 0.0957 None 0.007 N 0.269 0.048 0.128392430309 gnomAD-4.0.0 4.79004E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39731E-06 0 1.65695E-05
I/T 23222 Fn3-56 84 rs1223761195 0.091 -1.006 0.351 N 0.507 0.179 0.440810947182 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.52742E-04 None 0 None 0 0 0
I/T 23222 Fn3-56 84 rs1223761195 0.091 -1.006 0.351 N 0.507 0.179 0.440810947182 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93874E-04 None 0 0 0 0 0
I/T 23222 Fn3-56 84 rs1223761195 0.091 -1.006 0.351 N 0.507 0.179 0.440810947182 gnomAD-4.0.0 6.57462E-06 None None None None N None 0 0 None 0 1.93874E-04 None 0 0 0 0 0
I/V 23222 Fn3-56 84 rs766103673 0.0595 -1.119 None N 0.207 0.031 0.192905019026 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/A 23324 Fn3-57 85 None 0.0967 None None N 0.25 0.089 0.388174495139 gnomAD-4.0.0 1.36898E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79942E-06 0 0
V/F 23324 Fn3-57 85 None 0.134 None 0.171 N 0.625 0.103 0.629781192331 gnomAD-4.0.0 3.18564E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72164E-06 0 0
V/I 23324 Fn3-57 85 rs1710011007 0.0651 None None N 0.234 0.053 0.315903272564 gnomAD-4.0.0 1.59282E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4348E-05 0
R/K 23613 Fn3-59 82 rs1383287130 0.1391 None 0.795 N 0.475 0.081 0.168933306366 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/K 23613 Fn3-59 82 rs1383287130 0.1391 None 0.795 N 0.475 0.081 0.168933306366 gnomAD-4.0.0 6.57454E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47054E-05 0 0
K/E 23909 Fn3-61 84 rs557406526 0.2246 0.021 0.815 N 0.528 0.172 0.233150807113 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 4.65E-05 0 0
K/E 23909 Fn3-61 84 rs557406526 0.2246 0.021 0.815 N 0.528 0.172 0.233150807113 gnomAD-4.0.0 1.59184E-06 None None None None I None 0 0 None 0 0 None 1.88359E-05 0 0 0 0
I/V 24008 Fn3-62 85 rs1288081911 0.0564 -0.451 None N 0.205 0.097 0.107399877778 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 5.58E-05 None 3.27E-05 None 0 0 0
I/V 24008 Fn3-62 85 rs1288081911 0.0564 -0.451 None N 0.205 0.097 0.107399877778 gnomAD-4.0.0 3.18329E-06 None None None None I None 0 0 None 0 2.77546E-05 None 0 0 0 1.43303E-05 0
V/L 24205 Fn3-63 84 rs1322881049 0.1606 None 0.997 N 0.679 0.254 0.413241256734 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 24205 Fn3-63 84 rs1322881049 0.1606 None 0.997 N 0.679 0.254 0.413241256734 gnomAD-4.0.0 6.57609E-06 None None None None N None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
V/M 24205 Fn3-63 84 None 0.1194 None 1.0 N 0.827 0.263 0.453307948783 gnomAD-4.0.0 1.78312E-05 None None None None N None 0 0 None 0 0 None 0 0 2.07812E-05 0 3.6105E-05
I/S 24305 Fn3-64 84 None 0.2772 None 0.175 N 0.561 0.164 0.701967312675 gnomAD-4.0.0 1.60834E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.05064E-05
L/F 24407 Fn3-65 85 rs760989943 0.1071 -1.462 0.055 N 0.537 0.062 0.207176502487 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
L/F 24407 Fn3-65 85 rs760989943 0.1071 -1.462 0.055 N 0.537 0.062 0.207176502487 gnomAD-4.0.0 3.1844E-06 None None None None I None 0 2.28728E-05 None 0 0 None 0 2.41429E-04 0 0 0
L/H 24407 Fn3-65 85 rs72646896 0.1925 -1.306 0.612 N 0.583 0.258 0.652051462523 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
L/H 24407 Fn3-65 85 rs72646896 0.1925 -1.306 0.612 N 0.583 0.258 0.652051462523 gnomAD-4.0.0 2.05315E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69878E-06 0 0
L/P 24407 Fn3-65 85 rs72646896 0.1221 None 0.295 N 0.587 0.239 0.583519820621 gnomAD-4.0.0 1.36877E-06 None None None None I None 0 0 None 0 0 None 0 1.73551E-04 8.99593E-07 0 0
L/V 24407 Fn3-65 85 rs760989943 0.0681 None None N 0.217 0.074 0.128392430309 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 9.42E-05 0 0 0 0
L/V 24407 Fn3-65 85 rs760989943 0.0681 None None N 0.217 0.074 0.128392430309 gnomAD-4.0.0 6.57592E-06 None None None None I None 0 0 None 0 0 None 9.41974E-05 0 0 0 0
I/T 24601 Fn3-66 83 rs1021628897 0.2299 -0.826 0.06 N 0.692 0.282 0.576839456108 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 2.87853E-04 0 0
I/T 24601 Fn3-66 83 rs1021628897 0.2299 -0.826 0.06 N 0.692 0.282 0.576839456108 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 9.41E-05 0 0 0 0
I/T 24601 Fn3-66 83 rs1021628897 0.2299 -0.826 0.06 N 0.692 0.282 0.576839456108 gnomAD-4.0.0 1.86137E-06 None None None None I None 0 0 None 0 2.23744E-05 None 1.56274E-05 0 0 1.09835E-05 0
I/V 24601 Fn3-66 83 None 0.0711 None None N 0.279 0.063 0.283761946502 gnomAD-4.0.0 6.85229E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00891E-07 0 0
I/L 24991 Fn3-69 84 None 0.11 None 0.001 N 0.199 0.058 0.308278614506 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 24991 Fn3-69 84 rs744427 0.0899 -1.098 0.002 N 0.322 0.194 None gnomAD-2.1.1 4.79717E-03 None None None None I None 5.08888E-02 2.00894E-03 None 0 0 None 2.61489E-04 None 0 1.48952E-04 1.68539E-03
I/T 24991 Fn3-69 84 rs744427 0.0899 -1.098 0.002 N 0.322 0.194 None gnomAD-3.1.2 1.42177E-02 None None None None I None 4.97031E-02 4.45726E-03 0 0 1.93573E-04 None 9.43E-05 3.16456E-03 2.05894E-04 2.07297E-04 8.11843E-03
I/T 24991 Fn3-69 84 rs744427 0.0899 -1.098 0.002 N 0.322 0.194 None 1000 genomes 1.63738E-02 None None None None I None 5.82E-02 7.2E-03 None None 0 0 None None None 0 None
I/T 24991 Fn3-69 84 rs744427 0.0899 -1.098 0.002 N 0.322 0.194 None gnomAD-4.0.0 2.78409E-03 None None None None I None 5.20814E-02 2.51725E-03 None 0 2.23214E-05 None 1.56357E-05 1.98085E-03 1.5683E-04 1.9765E-04 3.4899E-03
F/I 25090 Fn3-70 85 rs762970043 0.0898 -0.708 0.193 N 0.429 0.074 0.0551355673512 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
F/I 25090 Fn3-70 85 rs762970043 0.0898 -0.708 0.193 N 0.429 0.074 0.0551355673512 gnomAD-4.0.0 4.77535E-06 None None None None N None 0 0 None 0 0 None 5.64738E-05 0 0 0 0
V/I 25287 Fn3-71 84 None 0.0692 None 0.016 N 0.267 0.033 0.28722502521 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 25387 Fn3-72 84 rs879225322 0.1189 None 0.942 N 0.691 0.186 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 1.09649E-03 0 0 None 0 0 0 0 4.78011E-04
L/F 25387 Fn3-72 84 rs879225322 0.1189 None 0.942 N 0.691 0.186 None gnomAD-4.0.0 4.3417E-06 None None None None I None 0 0 None 0 0 None 0 0 4.241E-06 0 1.60267E-05
L/I 25387 Fn3-72 84 None 0.0756 None 0.058 N 0.296 0.055 0.371344866733 gnomAD-4.0.0 6.84812E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16063E-05 0
V/G 25489 Fn3-73 85 None 0.3068 None 0.967 N 0.795 0.407 0.75040067796 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/F 25683 Fn3-74 83 rs375611562 0.1832 -1.308 0.073 N 0.583 0.215 0.424549175451 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/F 25683 Fn3-74 83 rs375611562 0.1832 -1.308 0.073 N 0.583 0.215 0.424549175451 gnomAD-4.0.0 1.36873E-06 None None None None I None 0 0 None 0 0 None 0 1.73611E-04 0 0 1.65717E-05
I/M 25683 Fn3-74 83 rs755225678 0.1154 -0.533 None N 0.339 0.072 0.19670166235 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/M 25683 Fn3-74 83 rs755225678 0.1154 -0.533 None N 0.339 0.072 0.19670166235 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 25683 Fn3-74 83 rs755225678 0.1154 -0.533 None N 0.339 0.072 0.19670166235 gnomAD-4.0.0 4.06001E-06 None None None None I None 0 0 None 0 0 None 0 0 4.81989E-06 0 0
I/S 25683 Fn3-74 83 None 0.3253 None 0.283 N 0.635 0.35 0.640388181781 gnomAD-4.0.0 1.59208E-06 None None None None I None 0 0 None 0 2.77516E-05 None 0 0 0 0 0
I/T 25683 Fn3-74 83 rs1707153104 0.1281 None 0.033 N 0.563 0.255 0.525049811399 gnomAD-4.0.0 1.59208E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85981E-06 0 0
I/V 25683 Fn3-74 83 rs375611562 0.0681 -0.862 None N 0.211 0.065 None gnomAD-2.1.1 1.79E-05 None None None None I None 2.0668E-04 0 None 0 0 None 0 None 0 0 0
I/V 25683 Fn3-74 83 rs375611562 0.0681 -0.862 None N 0.211 0.065 None gnomAD-3.1.2 7.89E-05 None None None None I None 2.65418E-04 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 25683 Fn3-74 83 rs375611562 0.0681 -0.862 None N 0.211 0.065 None gnomAD-4.0.0 1.17771E-05 None None None None I None 2.40372E-04 0 None 0 0 None 0 0 8.47767E-07 0 0
Q/L 25973 Fn3-76 84 rs1481076140 0.1445 0.044 0.064 N 0.564 0.194 0.293147016451 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/L 25973 Fn3-76 84 rs1481076140 0.1445 0.044 0.064 N 0.564 0.194 0.293147016451 gnomAD-4.0.0 3.18343E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86558E-05 0
V/I 26073 Fn3-77 84 rs769707850 0.0564 -0.932 None N 0.205 0.092 0.137902524267 gnomAD-2.1.1 1.61E-05 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 2.67E-05 0
V/I 26073 Fn3-77 84 rs769707850 0.0564 -0.932 None N 0.205 0.092 0.137902524267 gnomAD-4.0.0 4.10578E-06 None None None None I None 2.99007E-05 0 None 0 0 None 0 0 4.49796E-06 0 0
V/L 26073 Fn3-77 84 None 0.1276 None 0.004 N 0.297 0.099 0.170165803431 gnomAD-4.0.0 6.84297E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99591E-07 0 0
I/V 26172 Fn3-78 85 None 0.0633 None None N 0.239 0.062 0.167679373172 gnomAD-4.0.0 1.59552E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.03122E-05
V/G 26369 Fn3-79 84 None 0.224 None 0.062 N 0.571 0.217 0.57186346447 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 26369 Fn3-79 84 rs778729064 0.0661 -0.685 None N 0.257 0.056 0.195762928549 gnomAD-3.1.2 1.97E-05 None None None None I None 0 1.31079E-04 0 0 0 None 0 0 0 0 4.78011E-04
V/I 26369 Fn3-79 84 rs778729064 0.0661 -0.685 None N 0.257 0.056 0.195762928549 gnomAD-4.0.0 8.96861E-06 None None None None I None 0 3.38903E-05 None 0 0 None 0 0 0 0 1.42207E-04
V/A 26469 Fn3-80 84 None 0.1352 None 0.517 N 0.585 0.217 0.416075642716 gnomAD-4.0.0 1.592E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02572E-05
V/I 26469 Fn3-80 84 rs540254651 0.0604 -0.707 0.003 N 0.243 0.022 0.176091768786 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
V/I 26469 Fn3-80 84 rs540254651 0.0604 -0.707 0.003 N 0.243 0.022 0.176091768786 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
V/I 26469 Fn3-80 84 rs540254651 0.0604 -0.707 0.003 N 0.243 0.022 0.176091768786 gnomAD-4.0.0 8.11889E-06 None None None None N None 3.48663E-05 0 None 0 0 None 0 0 7.22972E-06 0 0
L/F 26571 Fn3-81 85 rs879058004 0.1051 None 0.81 N 0.587 0.176 0.378148810121 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 26571 Fn3-81 85 rs879058004 0.1051 None 0.81 N 0.587 0.176 0.378148810121 gnomAD-4.0.0 3.8447E-06 None None None None I None 0 0 None 0 0 None 0 0 7.18074E-06 0 0
L/I 26571 Fn3-81 85 None 0.0731 None 0.002 N 0.216 0.028 0.162503812791 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
V/G 26765 Fn3-82 83 rs1469008305 0.2545 -1.328 0.317 N 0.628 0.358 0.695986974221 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/G 26765 Fn3-82 83 rs1469008305 0.2545 -1.328 0.317 N 0.628 0.358 0.695986974221 gnomAD-4.0.0 1.5916E-06 None None None None I None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
K/E 27055 Fn3-84 84 None 0.4116 None 0.324 N 0.503 0.239 0.166414681773 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/N 27055 Fn3-84 84 None 0.7293 None 0.627 N 0.584 0.109 0.159798565429 gnomAD-4.0.0 1.59565E-06 None None None None I None 0 0 None 0 2.77469E-05 None 0 0 0 0 0
I/T 27155 Fn3-85 84 rs397517720 0.0846 -0.877 0.549 N 0.519 0.277 None gnomAD-2.1.1 7.15E-05 None None None None I None 2.48077E-04 2.84E-05 None 0 0 None 1.96168E-04 None 0 5.48E-05 0
I/T 27155 Fn3-85 84 rs397517720 0.0846 -0.877 0.549 N 0.519 0.277 None gnomAD-3.1.2 1.11739E-04 None None None None I None 4.10093E-04 0 0 0 0 None 0 0 0 0 0
I/T 27155 Fn3-85 84 rs397517720 0.0846 -0.877 0.549 N 0.519 0.277 None gnomAD-4.0.0 4.46255E-05 None None None None I None 4.4054E-04 1.66817E-05 None 0 2.23384E-05 None 0 0 2.03439E-05 9.88207E-05 6.40636E-05
F/L 27254 Fn3-86 85 rs958378883 0.3243 -1.156 None N 0.224 0.075 0.0401082797425 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
F/L 27254 Fn3-86 85 rs958378883 0.3243 -1.156 None N 0.224 0.075 0.0401082797425 gnomAD-4.0.0 1.02638E-05 None None None None N None 0 0 None 0 0 None 0 0 2.69842E-06 4.63725E-05 1.32534E-04
V/G 27552 Fn3-88 84 rs1215140042 0.2114 None 0.773 N 0.694 0.403 0.798687382396 gnomAD-4.0.0 1.5914E-06 None None None None N None 5.65547E-05 0 None 0 0 None 0 0 0 0 0
V/M 27552 Fn3-88 84 rs368730078 0.1113 -0.556 0.09 N 0.446 0.109 None gnomAD-2.1.1 1.07E-05 None None None None N None 8.27E-05 0 None 0 5.14E-05 None 0 None 0 0 0
V/M 27552 Fn3-88 84 rs368730078 0.1113 -0.556 0.09 N 0.446 0.109 None gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 1.93274E-04 None 0 0 0 0 0
V/M 27552 Fn3-88 84 rs368730078 0.1113 -0.556 0.09 N 0.446 0.109 None gnomAD-4.0.0 7.6876E-06 None None None None N None 5.07511E-05 0 None 0 7.28332E-05 None 0 0 0 0 0
V/I 27654 Fn3-89 85 rs1027584774 0.0635 None 0.014 N 0.323 0.067 0.254761474806 gnomAD-4.0.0 6.36557E-06 None None None None I None 0 0 None 0 5.54539E-05 None 0 0 0 0 6.04887E-05
I/T 27848 Fn3-90 83 rs397517723 0.0951 -0.433 0.003 N 0.465 0.118 0.52170519339 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
I/T 27848 Fn3-90 83 rs397517723 0.0951 -0.433 0.003 N 0.465 0.118 0.52170519339 gnomAD-4.0.0 4.11295E-06 None None None None I None 0 0 None 0 0 None 0 0 5.4013E-06 0 0
R/I 27944 Fn3-91 82 rs773829475 0.1097 0.288 0.295 N 0.517 0.15 0.373715746628 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 1.11732E-04 None 0 None 0 0 0
R/I 27944 Fn3-91 82 rs773829475 0.1097 0.288 0.295 N 0.517 0.15 0.373715746628 gnomAD-4.0.0 3.1847E-06 None None None None N None 0 0 None 0 5.55216E-05 None 0 0 0 0 0
R/K 27944 Fn3-91 82 rs773829475 0.0585 -0.128 None N 0.215 0.106 0.126345400529 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/K 27944 Fn3-91 82 rs773829475 0.0585 -0.128 None N 0.215 0.106 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
R/K 27944 Fn3-91 82 rs773829475 0.0585 -0.128 None N 0.215 0.106 0.126345400529 gnomAD-4.0.0 2.5635E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39367E-06 1.34149E-05 0
K/E 28137 Fn3-92 83 None 0.2757 None 0.124 N 0.585 0.123 0.199424873507 gnomAD-4.0.0 2.04055E-05 None None None None I None 0 0 None 0 0 None 0 0 2.23125E-05 0 0
K/M 28137 Fn3-92 83 None 0.2418 None 0.958 N 0.72 0.299 0.326616659874 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/M 28237 Fn3-93 84 rs1703616150 0.1199 None 0.971 N 0.724 0.244 0.343101102393 gnomAD-4.0.0 2.73681E-06 None None None None I None 2.98793E-05 6.70811E-05 None 0 0 None 0 0 0 0 0
I/S 28237 Fn3-93 84 rs1479599357 0.3522 -1.622 0.698 N 0.75 0.33 0.663906303568 gnomAD-4.0.0 1.59123E-06 None None None None I None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
V/G 28336 Fn3-94 85 None 0.3727 None 0.055 N 0.45 0.225 0.514587094315 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/L 28336 Fn3-94 85 rs375593513 0.1165 -0.741 None N 0.14 0.088 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 1.65673E-04
V/L 28336 Fn3-94 85 rs375593513 0.1165 -0.741 None N 0.14 0.088 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/L 28336 Fn3-94 85 rs375593513 0.1165 -0.741 None N 0.14 0.088 None gnomAD-4.0.0 3.09842E-05 None None None None N None 0 0 None 0 0 None 0 0 3.98361E-05 0 4.80338E-05
V/I 28533 Fn3-95 84 None 0.0717 None 0.826 N 0.443 0.159 0.408307896497 gnomAD-4.0.0 1.59252E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85953E-06 0 0
L/R 28633 Fn3-96 84 None 0.2127 None 0.997 N 0.812 0.395 0.722873759412 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/G 28733 Fn3-97 83 rs776120734 0.1221 -1.224 0.491 N 0.477 0.156 0.188950314367 gnomAD-2.1.1 4.03E-05 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 8.01E-05 0
A/G 28733 Fn3-97 83 rs776120734 0.1221 -1.224 0.491 N 0.477 0.156 0.188950314367 gnomAD-4.0.0 1.43687E-05 None None None None I None 0 4.47247E-05 None 0 0 None 0 0 7.19564E-06 0 1.82222E-04
V/I 28927 Fn3-98 83 None 0.062 None None N 0.197 0.056 0.139678290688 gnomAD-4.0.0 3.60098E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93752E-06 0 0
I/V 29220 Fn3-100 84 rs1553554246 0.0767 None 0.043 N 0.365 0.119 0.441844919209 gnomAD-4.0.0 1.36833E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99423E-07 0 1.65645E-05
V/I 29320 Fn3-101 84 rs765724248 0.0556 -0.915 None N 0.275 0.129 0.144782658237 gnomAD-2.1.1 2.01E-05 None None None None I None 0 0 None 4.97611E-04 0 None 0 None 0 0 0
V/I 29320 Fn3-101 84 rs765724248 0.0556 -0.915 None N 0.275 0.129 0.144782658237 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 2.88351E-04 0 None 0 0 0 0 0
V/I 29320 Fn3-101 84 rs765724248 0.0556 -0.915 None N 0.275 0.129 0.144782658237 gnomAD-4.0.0 1.11535E-05 None None None None I None 0 0 None 4.05405E-04 0 None 0 0 2.54262E-06 0 4.80338E-05
I/S 29419 Fn3-102 85 rs1406975324 0.2513 -1.135 0.029 N 0.617 0.21 0.630346058385 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/S 29419 Fn3-102 85 rs1406975324 0.2513 -1.135 0.029 N 0.617 0.21 0.630346058385 gnomAD-4.0.0 1.59131E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
I/V 29419 Fn3-102 85 rs1273849394 0.0635 None None N 0.231 0.066 0.262662153117 gnomAD-4.0.0 1.59131E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
I/F 29616 Fn3-103 84 rs768798726 0.1443 None 0.317 N 0.584 0.105 None gnomAD-4.0.0 1.59433E-06 None None None None N None 0 0 None 0 0 None 1.88872E-05 0 0 0 0
I/N 29616 Fn3-103 84 None 0.2266 None 0.484 N 0.653 0.339 0.666472316455 gnomAD-4.0.0 1.59284E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85915E-06 0 0
Q/P 29716 Fn3-104 84 rs1482572884 0.093 -0.412 None N 0.29 0.094 0.144782658237 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 3.31E-05 None 0 0 0
Q/P 29716 Fn3-104 84 rs1482572884 0.093 -0.412 None N 0.29 0.094 0.144782658237 gnomAD-4.0.0 1.60012E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4403E-05 0
Q/K 29818 Fn3-105 85 None 0.068 None 0.002 N 0.29 0.086 0.101711395817 gnomAD-4.0.0 1.59127E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
I/T 30015 Fn3-106 83 rs1289787170 0.0997 -0.799 0.001 N 0.336 0.086 0.40218521252 gnomAD-2.1.1 1.43E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.13E-05 0
I/T 30015 Fn3-106 83 rs1289787170 0.0997 -0.799 0.001 N 0.336 0.086 0.40218521252 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 30015 Fn3-106 83 rs1289787170 0.0997 -0.799 0.001 N 0.336 0.086 0.40218521252 gnomAD-4.0.0 9.91505E-06 None None None None I None 0 0 None 0 0 None 0 0 1.27138E-05 0 1.60097E-05
L/P 30111 Fn3-107 82 rs368516973 0.2351 -1.312 0.106 N 0.529 0.186 None gnomAD-2.1.1 3.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 7.03E-05 0
L/P 30111 Fn3-107 82 rs368516973 0.2351 -1.312 0.106 N 0.529 0.186 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
L/P 30111 Fn3-107 82 rs368516973 0.2351 -1.312 0.106 N 0.529 0.186 None gnomAD-4.0.0 5.57713E-05 None None None None I None 0 0 None 0 0 None 0 0 7.37391E-05 0 4.80338E-05
V/D 30307 Fn3-108 84 rs1452208068 0.6027 -1.252 1.0 N 0.815 0.536 0.836410672133 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/D 30307 Fn3-108 84 rs1452208068 0.6027 -1.252 1.0 N 0.815 0.536 0.836410672133 gnomAD-4.0.0 1.59722E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87434E-06 0 0
L/P 30407 Fn3-109 84 rs778086508 0.2078 -1.341 1.0 N 0.831 0.435 0.80318517577 gnomAD-2.1.1 8.07E-06 None None None None I None 0 0 None 0 0 None 6.59E-05 None 0 0 0
L/P 30407 Fn3-109 84 rs778086508 0.2078 -1.341 1.0 N 0.831 0.435 0.80318517577 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 30407 Fn3-109 84 rs778086508 0.2078 -1.341 1.0 N 0.831 0.435 0.80318517577 gnomAD-4.0.0 1.02815E-05 None None None None I None 0 0 None 0 0 None 0 0 2.40269E-06 9.41772E-05 0
V/A 30803 Fn3-112 85 None 0.1236 None 0.104 N 0.513 0.201 0.419335720491 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
K/E 30904 Fn3-113 84 rs370265204 0.1451 0.476 0.046 N 0.265 0.161 None gnomAD-2.1.1 2.85E-05 None None None None I None 3.30579E-04 0 None 0 0 None 0 None 0 0 0
K/E 30904 Fn3-113 84 rs370265204 0.1451 0.476 0.046 N 0.265 0.161 None gnomAD-3.1.2 7.88E-05 None None None None I None 2.89394E-04 0 0 0 0 None 0 0 0 0 0
K/E 30904 Fn3-113 84 rs370265204 0.1451 0.476 0.046 N 0.265 0.161 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
K/E 30904 Fn3-113 84 rs370265204 0.1451 0.476 0.046 N 0.265 0.161 None gnomAD-4.0.0 2.5404E-05 None None None None I None 4.79616E-04 1.66617E-05 None 0 0 None 0 0 0 0 6.40184E-05
V/A 31098 Fn3-114 83 None 0.0847 None 0.052 N 0.401 0.094 0.337378238328 gnomAD-4.0.0 6.84183E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99436E-07 0 0
V/D 31098 Fn3-114 83 rs886378576 0.2136 None 0.317 N 0.545 0.197 0.682257776623 gnomAD-4.0.0 6.84183E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99436E-07 0 0
V/I 31098 Fn3-114 83 rs760282296 0.0613 -0.384 None N 0.197 0.075 None gnomAD-2.1.1 3.93E-05 None None None None I None 2.47975E-04 1.41403E-04 None 0 0 None 0 None 0 0 0
V/I 31098 Fn3-114 83 rs760282296 0.0613 -0.384 None N 0.197 0.075 None gnomAD-3.1.2 8.54E-05 None None None None I None 3.13661E-04 0 0 0 0 None 0 0 0 0 0
V/I 31098 Fn3-114 83 rs760282296 0.0613 -0.384 None N 0.197 0.075 None gnomAD-4.0.0 1.85904E-05 None None None None I None 2.93647E-04 1.0002E-04 None 0 0 None 0 0 0 0 3.20205E-05
Y/C 31194 Fn3-115 82 rs543223589 0.0909 -0.398 0.009 N 0.437 0.235 0.286465849087 gnomAD-2.1.1 4.64E-05 None None None None N None 4.13E-05 1.41435E-04 None 0 0 None 1.30727E-04 None 0 2.34E-05 0
Y/C 31194 Fn3-115 82 rs543223589 0.0909 -0.398 0.009 N 0.437 0.235 0.286465849087 gnomAD-3.1.2 3.94E-05 None None None None N None 2.41E-05 1.96541E-04 0 0 0 None 0 0 0 4.14422E-04 0
Y/C 31194 Fn3-115 82 rs543223589 0.0909 -0.398 0.009 N 0.437 0.235 0.286465849087 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
Y/C 31194 Fn3-115 82 rs543223589 0.0909 -0.398 0.009 N 0.437 0.235 0.286465849087 gnomAD-4.0.0 2.04475E-05 None None None None N None 1.33255E-05 1.83339E-04 None 0 0 None 0 0 9.32347E-06 8.78349E-05 3.20082E-05
V/I 31391 Fn3-116 84 None 0.0732 None 0.039 N 0.27 0.12 0.320256813643 gnomAD-4.0.0 6.85386E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00584E-07 0 0
V/F 31491 Fn3-117 84 None 0.182 None 0.028 N 0.39 0.167 0.717020191167 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/S 31790 Fn3-119 83 rs1235693684 0.1408 -0.845 0.781 N 0.697 0.224 0.27132560031 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
P/S 31790 Fn3-119 83 rs1235693684 0.1408 -0.845 0.781 N 0.697 0.224 0.27132560031 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/S 31790 Fn3-119 83 rs1235693684 0.1408 -0.845 0.781 N 0.697 0.224 0.27132560031 gnomAD-4.0.0 2.56222E-06 None None None None N None 1.69165E-05 0 None 0 0 None 0 0 2.39311E-06 0 0
N/D 31891 Fn3-120 85 rs1351753792 0.1517 0.19 0.035 N 0.184 0.138 0.128392430309 gnomAD-2.1.1 8.1E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.79E-05 0
N/D 31891 Fn3-120 85 rs1351753792 0.1517 0.19 0.035 N 0.184 0.138 0.128392430309 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/D 31891 Fn3-120 85 rs1351753792 0.1517 0.19 0.035 N 0.184 0.138 0.128392430309 gnomAD-4.0.0 6.57039E-06 None None None None I None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
M/I 31993 Fn3-121 85 rs749913152 0.2123 0.119 None N 0.193 0.08 0.356897458496 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
M/I 31993 Fn3-121 85 rs749913152 0.2123 0.119 None N 0.193 0.08 0.356897458496 gnomAD-4.0.0 6.84229E-07 None None None None I None 2.98811E-05 0 None 0 0 None 0 0 0 0 0
M/L 31993 Fn3-121 85 None 0.1005 None 0.003 N 0.181 0.121 0.459995458672 gnomAD-4.0.0 3.1827E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71719E-06 0 0
I/N 32187 Fn3-122 83 rs1377093791 0.6885 -0.511 0.998 N 0.765 0.453 0.810754376879 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/N 32187 Fn3-122 83 rs1377093791 0.6885 -0.511 0.998 N 0.765 0.453 0.810754376879 gnomAD-4.0.0 1.59123E-06 None None None None I None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
I/T 32187 Fn3-122 83 rs1377093791 0.2003 -0.983 0.863 N 0.585 0.344 0.650048549417 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 9.95E-05 0 None 0 None 0 1.78E-05 0
I/T 32187 Fn3-122 83 rs1377093791 0.2003 -0.983 0.863 N 0.585 0.344 0.650048549417 gnomAD-4.0.0 4.7737E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 9.07221E-05
V/A 32285 Fn3-123 84 rs878898914 0.173 -1.804 0.002 N 0.243 0.083 None gnomAD-2.1.1 3.22E-05 None None None None I None 1.15902E-04 0 None 0 0 None 0 None 0 0 0
V/A 32285 Fn3-123 84 rs878898914 0.173 -1.804 0.002 N 0.243 0.083 None gnomAD-3.1.2 1.99E-05 None None None None I None 7.33E-05 0 0 0 0 None 0 0 0 0 0
V/M 32285 Fn3-123 84 rs747046501 0.1261 -0.946 0.009 N 0.468 0.066 0.18274738541 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 1.11284E-04 None 3.28E-05 None 0 8.89E-06 0
V/M 32285 Fn3-123 84 rs747046501 0.1261 -0.946 0.009 N 0.468 0.066 0.18274738541 gnomAD-3.1.2 6.6E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.08594E-04 0
V/M 32285 Fn3-123 84 rs747046501 0.1261 -0.946 0.009 N 0.468 0.066 0.18274738541 gnomAD-4.0.0 5.14767E-06 None None None None I None 0 0 None 0 7.28757E-05 None 0 0 0 1.34246E-05 0
I/T 32482 Fn3-124 84 rs773555433 0.1309 -1.291 0.892 N 0.726 0.238 0.592138549 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.69E-05 0
I/T 32482 Fn3-124 84 rs773555433 0.1309 -1.291 0.892 N 0.726 0.238 0.592138549 gnomAD-4.0.0 2.46521E-05 None None None None I None 0 0 None 0 0 None 1.87575E-05 0 2.87955E-05 1.16268E-05 3.3151E-05
S/F 32582 Fn3-125 84 None 0.1216 None 0.065 N 0.626 0.039 0.332902724076 gnomAD-4.0.0 6.35478E-06 None None None None I None 0 0 None 0 0 None 0 0 8.29071E-06 0 0
P/L 32683 Fn3-126 84 rs1693711060 0.0912 None 0.92 N 0.584 0.267 0.48748946032 gnomAD-4.0.0 6.85353E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01057E-07 0 0
P/R 32683 Fn3-126 84 rs1693711060 0.2043 None 0.988 N 0.656 0.384 0.376921832658 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
P/R 32683 Fn3-126 84 rs1693711060 0.2043 None 0.988 N 0.656 0.384 0.376921832658 gnomAD-4.0.0 1.24124E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.09938E-05 1.60375E-05
I/R 32878 Fn3-127 84 rs1239539070 0.4804 0.282 0.966 N 0.643 0.346 None gnomAD-2.1.1 7.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
I/R 32878 Fn3-127 84 rs1239539070 0.4804 0.282 0.966 N 0.643 0.346 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/R 32878 Fn3-127 84 rs1239539070 0.4804 0.282 0.966 N 0.643 0.346 None gnomAD-4.0.0 6.81656E-06 None None None None N None 0 0 None 0 0 None 0 0 9.3236E-06 0 0
L/P 32980 Fn3-128 85 None 0.3616 None 0.966 N 0.688 0.319 0.776386403144 gnomAD-4.0.0 4.77789E-06 None None None None N None 0 2.28697E-05 None 0 0 None 0 0 5.72384E-06 0 0
I/V 33374 Fn3-130 85 None 0.0955 None 0.219 N 0.253 0.108 0.42324137094 gnomAD-4.0.0 1.36885E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79927E-06 0 0
E/K 33475 Fn3-131 84 rs377287413 0.25 -0.749 0.999 N 0.755 0.41 None gnomAD-2.1.1 1.21E-05 None None None None N None 1.29349E-04 2.91E-05 None 0 0 None 0 None 0 0 0
E/K 33475 Fn3-131 84 rs377287413 0.25 -0.749 0.999 N 0.755 0.41 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
E/K 33475 Fn3-131 84 rs377287413 0.25 -0.749 0.999 N 0.755 0.41 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
E/K 33475 Fn3-131 84 rs377287413 0.25 -0.749 0.999 N 0.755 0.41 None gnomAD-4.0.0 9.91537E-06 None None None None N None 9.32935E-05 3.33489E-05 None 0 0 None 1.56406E-05 0 4.23822E-06 0 1.60087E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.