Structural position:

  • Domain Type: Ig
  • Aligned Position: 157
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand F

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
N/S 177 Ig-2 74 None 0.1244 None 0.13 N 0.305 0.115 0.128392430309 gnomAD-4.0.0 1.20032E-06 None None None -0.228(TCAP) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/G 1016 Ig-3 74 rs756789081 0.2363 -1.227 0.052 D 0.524 0.264 0.21279746466 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
S/G 1016 Ig-3 74 rs756789081 0.2363 -1.227 0.052 D 0.524 0.264 0.21279746466 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 1016 Ig-3 74 rs756789081 0.2363 -1.227 0.052 D 0.524 0.264 0.21279746466 gnomAD-4.0.0 2.5616E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78416E-06 0 0
S/R 1016 Ig-3 74 None 0.6147 None 0.117 N 0.619 0.271 0.180583059064 gnomAD-4.0.0 1.59105E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85714E-06 0 0
V/A 1157 Ig-4 76 rs1266730376 0.5394 -2.174 0.656 N 0.659 0.37 0.734822152697 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
V/A 1157 Ig-4 76 rs1266730376 0.5394 -2.174 0.656 N 0.659 0.37 0.734822152697 gnomAD-4.0.0 1.59073E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
V/I 1157 Ig-4 76 rs397517566 0.0992 -0.261 0.014 N 0.237 0.109 None gnomAD-2.1.1 6.02E-05 None None None None N None 0 2.82E-05 None 0 5.03E-05 None 3.27E-05 None 0 1.08605E-04 0
V/I 1157 Ig-4 76 rs397517566 0.0992 -0.261 0.014 N 0.237 0.109 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 4.77555E-04
V/I 1157 Ig-4 76 rs397517566 0.0992 -0.261 0.014 N 0.237 0.109 None gnomAD-4.0.0 4.21339E-05 None None None None N None 0 5.00083E-05 None 0 2.22946E-05 None 0 3.28839E-04 3.64418E-05 1.53714E-04 8.00205E-05
V/L 1157 Ig-4 76 rs397517566 0.4307 -0.264 0.125 N 0.462 0.221 0.600074432338 gnomAD-2.1.1 3.98E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
V/L 1157 Ig-4 76 rs397517566 0.4307 -0.264 0.125 N 0.462 0.221 0.600074432338 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/L 1157 Ig-4 76 rs397517566 0.4307 -0.264 0.125 N 0.462 0.221 0.600074432338 gnomAD-4.0.0 1.85885E-06 None None None None N None 4.00427E-05 0 None 0 0 None 0 0 0 0 0
V/D 1531 Ig-6 75 rs794727429 0.7257 None 0.879 D 0.867 0.582 0.875277342448 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
V/F 1531 Ig-6 75 None 0.2496 None 0.782 D 0.809 0.352 0.719773709958 gnomAD-4.0.0 6.84176E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9935E-07 0 0
V/I 1531 Ig-6 75 rs1246164291 0.0648 -0.332 0.001 N 0.275 0.053 0.349870743963 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.83E-06 0
V/I 1531 Ig-6 75 rs1246164291 0.0648 -0.332 0.001 N 0.275 0.053 0.349870743963 gnomAD-4.0.0 6.84176E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9935E-07 0 0
T/A 1631 Ig-7 76 rs1270981853 0.6329 -1.404 0.999 D 0.585 0.484 0.40218521252 gnomAD-2.1.1 4E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/A 1631 Ig-7 76 rs1270981853 0.6329 -1.404 0.999 D 0.585 0.484 0.40218521252 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
R/K 1778 Ig-8 76 None 0.169 None 0.997 N 0.553 0.369 0.311387274539 gnomAD-4.0.0 1.60005E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02334E-05
T/I 1913 Ig-9 73 None 0.1997 None 0.454 N 0.673 0.396 0.387689773709 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85657E-06 0 0
T/N 1913 Ig-9 73 rs1306092689 0.376 -1.318 0.934 N 0.707 0.235 0.440810947182 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/N 1913 Ig-9 73 rs1306092689 0.376 -1.318 0.934 N 0.707 0.235 0.440810947182 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 1913 Ig-9 73 rs1306092689 0.376 -1.318 0.934 N 0.707 0.235 0.440810947182 gnomAD-4.0.0 6.57333E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
T/S 1913 Ig-9 73 rs1306092689 0.1998 None 0.051 N 0.289 0.195 0.185906805712 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 1913 Ig-9 73 rs1306092689 0.1998 None 0.051 N 0.289 0.195 0.185906805712 gnomAD-4.0.0 6.57333E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
K/Q 2152 Ig-10 75 None 0.5259 None 1.0 N 0.817 0.458 0.357724736475 gnomAD-4.0.0 1.59064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85649E-06 0 0
V/L 2339 Ig-12 73 rs964493112 0.1662 -0.028 0.835 D 0.59 0.352 0.608796909167 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
V/L 2339 Ig-12 73 rs964493112 0.1662 -0.028 0.835 D 0.59 0.352 0.608796909167 gnomAD-4.0.0 1.59059E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
T/A 2428 Ig-13 73 None 0.0784 None None N 0.203 0.081 0.165133752707 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 2428 Ig-13 73 rs1372427640 0.1039 0.131 0.003 N 0.339 0.2 0.347659731818 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
T/I 2428 Ig-13 73 rs1372427640 0.1039 0.131 0.003 N 0.339 0.2 0.347659731818 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07469E-04 0
T/I 2428 Ig-13 73 rs1372427640 0.1039 0.131 0.003 N 0.339 0.2 0.347659731818 gnomAD-4.0.0 3.842E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78391E-06 1.34016E-05 0
T/N 2428 Ig-13 73 None 0.0901 None 0.001 N 0.3 0.121 0.326345978581 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 2428 Ig-13 73 None 0.0901 None 0.001 N 0.3 0.121 0.326345978581 gnomAD-4.0.0 6.57272E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47037E-05 0 0
I/K 2518 Ig-14 74 None 0.1581 None 0.014 N 0.493 0.222 0.646115140387 gnomAD-4.0.0 6.84105E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99319E-07 0 0
I/T 2518 Ig-14 74 rs1319910280 0.0806 -2.098 0.003 N 0.333 0.184 0.594367484798 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
I/T 2518 Ig-14 74 rs1319910280 0.0806 -2.098 0.003 N 0.333 0.184 0.594367484798 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 0 1.47E-05 0 0
I/T 2518 Ig-14 74 rs1319910280 0.0806 -2.098 0.003 N 0.333 0.184 0.594367484798 gnomAD-4.0.0 2.47837E-06 None None None None N None 0 3.33389E-05 None 0 0 None 0 0 1.69495E-06 0 0
I/V 2518 Ig-14 74 rs2091831608 0.0636 None None N 0.127 0.104 0.40146981186 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Y/H 2605 Ig-15 73 None 0.0876 None None N 0.242 0.226 0.286848849266 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
K/N 2692 Ig-16 72 None 0.2915 None 0.175 N 0.449 0.154 0.166414681773 gnomAD-4.0.0 8.20914E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89234E-06 0 1.65574E-05
V/M 2867 Ig-18 73 None 0.0707 None 0.02 D 0.434 0.19 0.441118900842 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/D 2954 Ig-19 73 rs973559075 0.8894 None 0.999 N 0.829 0.734 0.856560271015 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/F 2954 Ig-19 73 rs762256991 0.3921 -1.228 0.998 D 0.777 0.485 0.842836954303 gnomAD-2.1.1 5.33E-05 None None None None N None 0 0 None 0 0 None 0 None 5.98182E-04 0 0
V/F 2954 Ig-19 73 rs762256991 0.3921 -1.228 0.998 D 0.777 0.485 0.842836954303 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.47E-05 0 0 0 0
V/F 2954 Ig-19 73 rs762256991 0.3921 -1.228 0.998 D 0.777 0.485 0.842836954303 gnomAD-4.0.0 1.17756E-05 None None None None N None 0 0 None 0 0 None 2.97358E-04 0 0 0 0
V/I 2954 Ig-19 73 None 0.0815 None 0.543 N 0.273 0.183 0.60324968888 gnomAD-4.0.0 6.84212E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99433E-07 0 0
V/A 3041 Ig-20 73 None 0.3128 -1.742 0.999 D 0.627 0.427 0.695208288813 gnomAD-2.1.1 1.59E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 8.8E-06 0
V/A 3041 Ig-20 73 None 0.3128 -1.742 0.999 D 0.627 0.427 0.695208288813 gnomAD-4.0.0 1.27253E-05 None None None None N None 0 0 None 0 0 None 0 0 8.56952E-06 7.16373E-05 0
V/L 3041 Ig-20 73 None 0.3475 None 0.997 N 0.589 0.288 0.578230335649 gnomAD-4.0.0 1.59064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85652E-06 0 0
V/A 3130 Ig-21 73 None 0.3961 None 0.999 D 0.639 0.511 0.715916371082 gnomAD-4.0.0 1.59051E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85646E-06 0 0
V/A 3221 Ig-22 75 rs1445925686 0.3982 -1.082 0.309 N 0.553 0.311 0.540788926979 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.44E-05 None 0 None 0 0 0
V/A 3221 Ig-22 75 rs1445925686 0.3982 -1.082 0.309 N 0.553 0.311 0.540788926979 gnomAD-4.0.0 1.59053E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
I/T 3733 Ig-26 74 rs1263923996 0.0794 None None None None 0.157 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 3733 Ig-26 74 rs1263923996 0.0794 None None None None 0.157 None gnomAD-4.0.0 6.56849E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46977E-05 0 0
I/V 3733 Ig-26 74 rs767095590 0.0704 -1.251 None None None 0.123 None gnomAD-2.1.1 2.41E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 3.55E-05 1.65893E-04
I/V 3733 Ig-26 74 rs767095590 0.0704 -1.251 None None None 0.123 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 3733 Ig-26 74 rs767095590 0.0704 -1.251 None None None 0.123 None gnomAD-4.0.0 4.95728E-06 None None None None N None 0 1.66656E-05 None 0 0 None 0 0 5.08561E-06 0 1.60108E-05
M/I 3893 Ig-27 74 rs2154318912 0.1617 None None N 0.155 0.1 None gnomAD-4.0.0 3.18234E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71598E-06 0 0
M/T 3893 Ig-27 74 rs1553941782 0.1318 None None N 0.244 0.122 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/T 3893 Ig-27 74 rs1553941782 0.1318 None None N 0.244 0.122 None gnomAD-4.0.0 5.57719E-06 None None None None I None 0 0 None 0 0 None 0 0 7.62835E-06 0 0
K/N 4012 Ig-28 75 rs763904872 0.7996 -1.054 0.117 D 0.545 0.16 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/N 4012 Ig-28 75 rs763904872 0.7996 -1.054 0.117 D 0.545 0.16 None gnomAD-4.0.0 1.59246E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
E/A 4678 Ig-29 73 rs768807991 0.308 -0.831 0.999 D 0.691 0.459 None gnomAD-2.1.1 2.97E-05 None None None None N None 0 0 None 0 0 None 3.24149E-04 None 0 0 0
E/A 4678 Ig-29 73 rs768807991 0.308 -0.831 0.999 D 0.691 0.459 None gnomAD-4.0.0 9.3372E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.64433E-04 1.74331E-05
E/K 4678 Ig-29 73 rs1361758337 0.1758 -1.121 0.999 N 0.607 0.333 None gnomAD-2.1.1 4.94E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.05E-05 0
E/K 4678 Ig-29 73 rs1361758337 0.1758 -1.121 0.999 N 0.607 0.333 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 4678 Ig-29 73 rs1361758337 0.1758 -1.121 0.999 N 0.607 0.333 None gnomAD-4.0.0 4.21641E-06 None None None None N None 0 0 None 0 0 None 0 0 7.85016E-06 0 0
K/E 4773 Ig-30 74 None 0.2774 None 0.698 N 0.588 0.352 0.281780670237 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 4773 Ig-30 74 None 0.1002 None 0.014 N 0.379 0.2 0.349647731962 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
K/E 4868 Ig-31 74 rs1276077770 0.4836 -0.392 0.939 N 0.587 0.366 0.39724302092 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/E 4868 Ig-31 74 rs1276077770 0.4836 -0.392 0.939 N 0.587 0.366 0.39724302092 gnomAD-4.0.0 1.5913E-06 None None None None I None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
K/R 4868 Ig-31 74 None 0.1203 None 0.1 N 0.383 0.118 0.245101548738 gnomAD-4.0.0 2.40067E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62503E-06 0 0
T/I 4961 Ig-32 74 rs1298192031 0.0945 -0.232 0.998 N 0.743 0.3 0.373537453441 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
T/I 4961 Ig-32 74 rs1298192031 0.0945 -0.232 0.998 N 0.743 0.3 0.373537453441 gnomAD-4.0.0 1.59675E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86285E-06 0 0
T/R 4961 Ig-32 74 None 0.1251 None 0.999 N 0.814 0.381 0.397838977388 gnomAD-4.0.0 1.59675E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86285E-06 0 0
E/D 5055 Ig-33 75 None 0.4931 None 0.999 D 0.578 0.294 0.336892272479 gnomAD-4.0.0 1.59185E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43373E-05 0
E/G 5055 Ig-33 75 rs1185775947 0.6174 None 1.0 D 0.81 0.595 0.631273993836 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 5055 Ig-33 75 rs1185775947 0.6174 None 1.0 D 0.81 0.595 0.631273993836 gnomAD-4.0.0 6.57004E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
E/K 5055 Ig-33 75 None 0.2156 None 0.999 N 0.663 0.369 0.450152462452 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
L/P 5241 Ig-35 74 rs1448200477 0.9666 None 0.989 D 0.707 0.512 0.841180832786 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 5241 Ig-35 74 rs1448200477 0.9666 None 0.989 D 0.707 0.512 0.841180832786 gnomAD-4.0.0 6.56944E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46977E-05 0 0
L/Q 5241 Ig-35 74 rs1448200477 0.0926 None 0.062 N 0.501 0.296 0.613699239204 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 2.41429E-04 0 0 0
R/Q 5430 Ig-37 74 rs746130933 0.1015 -0.744 0.175 N 0.358 0.244 0.18274738541 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.68275E-04 None 0 None 0 0 0
R/Q 5430 Ig-37 74 rs746130933 0.1015 -0.744 0.175 N 0.358 0.244 0.18274738541 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 5430 Ig-37 74 rs746130933 0.1015 -0.744 0.175 N 0.358 0.244 0.18274738541 gnomAD-4.0.0 3.71924E-06 None None None None I None 0 0 None 0 4.46768E-05 None 0 0 2.5432E-06 1.09868E-05 0
K/E 5523 Ig-38 74 rs755764408 0.1244 -0.569 0.055 N 0.545 0.199 0.276898752692 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
K/E 5523 Ig-38 74 rs755764408 0.1244 -0.569 0.055 N 0.545 0.199 0.276898752692 gnomAD-4.0.0 1.59185E-06 None None None None N None 0 0 None 0 2.77485E-05 None 0 0 0 0 0
R/L 5710 Ig-40 74 None 0.2298 None 0.729 N 0.497 0.332 0.545825192673 gnomAD-4.0.0 6.84264E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99515E-07 0 0
R/Q 5710 Ig-40 74 rs200018866 0.0964 -0.933 0.529 N 0.293 0.235 None gnomAD-2.1.1 6.44E-05 None None None None N None 3.72147E-04 1.13218E-04 None 0 5.13E-05 None 3.27E-05 None 0 2.35E-05 0
R/Q 5710 Ig-40 74 rs200018866 0.0964 -0.933 0.529 N 0.293 0.235 None gnomAD-3.1.2 1.97244E-04 None None None None N None 4.58738E-04 6.54793E-04 0 0 0 None 0 0 1.47E-05 0 0
R/Q 5710 Ig-40 74 rs200018866 0.0964 -0.933 0.529 N 0.293 0.235 None 1000 genomes None None None None None N None 0 0 None None 0 0 None None None 0 None
R/Q 5710 Ig-40 74 rs200018866 0.0964 -0.933 0.529 N 0.293 0.235 None gnomAD-4.0.0 5.51589E-05 None None None None N None 3.73892E-04 2.33427E-04 None 0 6.68837E-05 None 0 0 2.79726E-05 8.78522E-05 4.80384E-05
R/W 5710 Ig-40 74 rs1183941490 0.2256 -0.765 1.0 N 0.549 0.439 0.593515057505 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
R/W 5710 Ig-40 74 rs1183941490 0.2256 -0.765 1.0 N 0.549 0.439 0.593515057505 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 1.47E-05 0 0
R/W 5710 Ig-40 74 rs1183941490 0.2256 -0.765 1.0 N 0.549 0.439 0.593515057505 gnomAD-4.0.0 8.67657E-06 None None None None N None 0 0 None 0 2.22955E-05 None 0 0 1.10193E-05 0 0
Q/H 5803 Ig-41 74 rs914726368 0.4106 None None D 0.215 0.234 0.272205846399 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
E/K 5896 Ig-42 74 rs561557554 0.2369 -0.763 0.742 N 0.589 0.228 None gnomAD-2.1.1 2.07454E-04 None None None None N None 1.2408E-04 2.83E-05 None 0 0 None 1.73805E-03 None 0 7.83E-06 0
E/K 5896 Ig-42 74 rs561557554 0.2369 -0.763 0.742 N 0.589 0.228 None gnomAD-3.1.2 1.5133E-04 None None None None N None 2.89981E-04 0 0 0 0 None 0 3.16456E-03 1.47E-05 1.86722E-03 0
E/K 5896 Ig-42 74 rs561557554 0.2369 -0.763 0.742 N 0.589 0.228 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
E/K 5896 Ig-42 74 rs561557554 0.2369 -0.763 0.742 N 0.589 0.228 None gnomAD-4.0.0 9.79732E-05 None None None None N None 2.66951E-04 3.33511E-05 None 6.7659E-05 0 None 0 1.65344E-04 3.39242E-06 1.34089E-03 1.12093E-04
E/Q 5896 Ig-42 74 rs561557554 0.1548 None 0.722 N 0.563 0.18 0.21279746466 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 5896 Ig-42 74 rs561557554 0.1548 None 0.722 N 0.563 0.18 0.21279746466 gnomAD-4.0.0 2.48052E-06 None None None None N None 0 0 None 0 0 None 0 0 3.3924E-06 0 0
E/K 6179 Ig-45 75 None 0.2012 None 0.999 N 0.635 0.323 0.397540356873 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/V 6179 Ig-45 75 None 0.3022 None 1.0 N 0.852 0.465 0.539478914628 gnomAD-4.0.0 1.5914E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85869E-06 0 0
I/L 6272 Ig-46 74 rs1385000092 0.1128 -0.731 0.08 N 0.361 0.162 0.478068462777 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
I/L 6272 Ig-46 74 rs1385000092 0.1128 -0.731 0.08 N 0.361 0.162 0.478068462777 gnomAD-4.0.0 4.77594E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71948E-06 1.4332E-05 0
I/T 6272 Ig-46 74 rs1274096400 0.1096 -1.496 0.005 N 0.351 0.287 0.602402279407 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
I/T 6272 Ig-46 74 rs1274096400 0.1096 -1.496 0.005 N 0.351 0.287 0.602402279407 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 6272 Ig-46 74 rs1274096400 0.1096 -1.496 0.005 N 0.351 0.287 0.602402279407 gnomAD-4.0.0 6.57177E-06 None None None None N None 2.41231E-05 0 None 0 0 None 0 0 0 0 0
I/V 6272 Ig-46 74 None 0.07 None 0.001 N 0.218 0.078 0.530109961917 gnomAD-4.0.0 1.59198E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85974E-06 0 0
Q/R 6365 Ig-47 74 rs762632541 0.1557 -0.232 0.961 N 0.582 0.338 0.359963025489 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
Q/R 6365 Ig-47 74 rs762632541 0.1557 -0.232 0.961 N 0.582 0.338 0.359963025489 gnomAD-4.0.0 1.59546E-06 None None None None N None 0 0 None 0 2.77979E-05 None 0 0 0 0 0
K/R 6458 Ig-48 74 None 0.0855 None 0.961 N 0.553 0.265 0.380564188046 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/R 6554 Ig-49 74 rs2079687407 0.0735 None 0.002 N 0.375 0.084 0.211220785272 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
K/R 6554 Ig-49 74 rs2079687407 0.0735 None 0.002 N 0.375 0.084 0.211220785272 gnomAD-4.0.0 1.86322E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69811E-06 1.10468E-05 0
H/Q 6647 Ig-50 74 rs565190478 0.0669 -0.723 None N 0.174 0.097 0.0401082797425 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/Q 6647 Ig-50 74 rs565190478 0.0669 -0.723 None N 0.174 0.097 0.0401082797425 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
H/Q 6647 Ig-50 74 rs565190478 0.0669 -0.723 None N 0.174 0.097 0.0401082797425 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
H/R 6647 Ig-50 74 rs757799209 0.0664 -1.138 None N 0.194 0.154 0.197625483188 gnomAD-2.1.1 4.19E-06 None None None None N None 0 0 None 0 5.66E-05 None 0 None 0 0 0
H/R 6647 Ig-50 74 rs757799209 0.0664 -1.138 None N 0.194 0.154 0.197625483188 gnomAD-4.0.0 2.75954E-06 None None None None N None 0 0 None 0 2.52755E-05 None 0 0 2.71139E-06 0 0
E/G 6741 Ig-51 75 rs1380825036 0.6192 -1.96 0.999 N 0.718 0.341 0.589461000006 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
E/G 6741 Ig-51 75 rs1380825036 0.6192 -1.96 0.999 N 0.718 0.341 0.589461000006 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 6741 Ig-51 75 rs1380825036 0.6192 -1.96 0.999 N 0.718 0.341 0.589461000006 gnomAD-4.0.0 6.5735E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
K/N 6834 Ig-52 74 None 0.8374 None 0.645 N 0.554 0.161 0.166414681773 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/H 7021 Ig-54 74 rs757015621 0.1869 -1.508 0.927 N 0.587 0.381 0.257292322809 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.55E-05 0
Q/H 7021 Ig-54 74 rs757015621 0.1869 -1.508 0.927 N 0.587 0.381 0.257292322809 gnomAD-4.0.0 1.30028E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52932E-05 2.31927E-05 0
V/L 7117 Ig-55 74 None 0.1661 None 0.088 N 0.364 0.238 0.436886369515 gnomAD-4.0.0 7.52833E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99675E-06 0 1.65728E-05
V/M 7117 Ig-55 74 rs765385083 0.0983 -0.478 0.175 N 0.358 0.257 0.451023696535 gnomAD-2.1.1 2.86E-05 None None None None N None 0 0 None 0 2.56331E-04 None 3.27E-05 None 0 1.57E-05 0
V/M 7117 Ig-55 74 rs765385083 0.0983 -0.478 0.175 N 0.358 0.257 0.451023696535 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 5.78927E-04 None 0 0 1.47E-05 0 0
V/M 7117 Ig-55 74 rs765385083 0.0983 -0.478 0.175 N 0.358 0.257 0.451023696535 gnomAD-4.0.0 1.61161E-05 None None None None N None 0 0 None 0 2.67499E-04 None 0 1.6469E-04 8.47797E-06 3.29468E-05 0
V/A 7210 Ig-56 74 rs2078787546 0.1442 None 0.081 N 0.488 0.236 0.571137827458 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 7210 Ig-56 74 rs2078787546 0.1442 None 0.081 N 0.488 0.236 0.571137827458 gnomAD-4.0.0 6.57151E-06 None None None None N None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
V/M 7210 Ig-56 74 rs2078788121 0.0853 None 0.427 D 0.652 0.229 0.499154427049 gnomAD-4.0.0 2.73776E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59849E-06 0 0
E/G 7303 Ig-57 74 None 0.2206 None 0.549 N 0.646 0.391 0.49179695788 gnomAD-4.0.0 3.18351E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71817E-06 0 0
E/K 7303 Ig-57 74 rs774950387 0.1244 -1.245 0.084 N 0.275 0.221 0.332133492242 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
E/K 7303 Ig-57 74 rs774950387 0.1244 -1.245 0.084 N 0.275 0.221 0.332133492242 gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 7303 Ig-57 74 rs774950387 0.1244 -1.245 0.084 N 0.275 0.221 0.332133492242 gnomAD-4.0.0 1.54945E-05 None None None None N None 2.6708E-05 0 None 0 0 None 0 0 1.52585E-05 0 8.00692E-05
E/Q 7303 Ig-57 74 rs774950387 0.1036 None 0.756 N 0.587 0.122 0.263140351381 gnomAD-4.0.0 6.84304E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99556E-07 0 0
K/E 7396 Ig-58 74 None 0.1665 None 0.066 N 0.49 0.105 0.0884992946249 gnomAD-4.0.0 3.18563E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86845E-05 0
S/L 7492 Ig-59 74 rs745460696 0.0966 0.095 0.816 N 0.542 0.239 0.589461000006 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
S/L 7492 Ig-59 74 rs745460696 0.0966 0.095 0.816 N 0.542 0.239 0.589461000006 gnomAD-4.0.0 2.05522E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70071E-06 0 0
E/K 7682 Ig-61 75 rs761584703 0.125 -0.891 0.999 N 0.669 0.367 None gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.46E-05 0
E/K 7682 Ig-61 75 rs761584703 0.125 -0.891 0.999 N 0.669 0.367 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 7682 Ig-61 75 rs761584703 0.125 -0.891 0.999 N 0.669 0.367 None gnomAD-4.0.0 3.1094E-05 None None None None N None 0 0 None 0 0 None 1.56421E-05 1.64962E-04 3.99964E-05 0 1.60689E-05
K/Q 7775 Ig-62 74 rs771592871 0.3105 -0.479 0.252 N 0.615 0.217 0.190952846119 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
K/Q 7775 Ig-62 74 rs771592871 0.3105 -0.479 0.252 N 0.615 0.217 0.190952846119 gnomAD-4.0.0 1.90987E-05 None None None None N None 0 0 None 0 3.32779E-04 None 0 0 0 0 0
V/A 8058 Ig-65 74 rs1392397772 0.132 -1.903 0.027 D 0.457 0.238 0.536287059136 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/A 8058 Ig-65 74 rs1392397772 0.132 -1.903 0.027 D 0.457 0.238 0.536287059136 gnomAD-4.0.0 1.59134E-06 None None None None I None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
V/M 8058 Ig-65 74 rs1309625913 0.0897 -0.587 0.004 N 0.329 0.133 0.411665641125 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/M 8058 Ig-65 74 rs1309625913 0.0897 -0.587 0.004 N 0.329 0.133 0.411665641125 gnomAD-4.0.0 1.59134E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85848E-06 0 0
S/C 8433 Ig-69 74 None 0.1658 None 0.998 N 0.551 0.335 0.421550847248 gnomAD-4.0.0 6.84549E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99721E-07 0 0
Y/C 8529 Ig-70 74 None 0.124 None 0.967 N 0.595 0.371 0.595757661845 gnomAD-4.0.0 1.59197E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
E/D 8623 Ig-71 75 None 0.5638 None 0.969 N 0.508 0.325 0.36453787251 gnomAD-4.0.0 1.36861E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
E/G 8623 Ig-71 75 rs766190373 0.6709 -1.849 0.998 D 0.681 0.478 0.65995756008 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
Q/H 8810 Ig-73 75 rs781752797 0.3282 -1.302 0.241 D 0.373 0.304 0.373357554552 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 1.65948E-04
Q/H 8810 Ig-73 75 rs781752797 0.3282 -1.302 0.241 D 0.373 0.304 0.373357554552 gnomAD-4.0.0 9.57938E-06 None None None None N None 0 0 None 0 0 None 3.7456E-05 0 2.69853E-06 0 1.49081E-04
Q/L 8810 Ig-73 75 rs934473433 0.1803 0.187 0.989 D 0.642 0.434 0.554881495044 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
Q/L 8810 Ig-73 75 rs934473433 0.1803 0.187 0.989 D 0.642 0.434 0.554881495044 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/L 8810 Ig-73 75 rs934473433 0.1803 0.187 0.989 D 0.642 0.434 0.554881495044 gnomAD-4.0.0 5.12471E-06 None None None None N None 1.69159E-05 0 None 0 0 None 0 0 7.17992E-06 0 0
E/Q 8903 Ig-74 74 None 0.1173 None 0.996 N 0.65 0.234 0.277730125212 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 8999 Ig-75 74 rs1281961108 0.0844 -1.926 None N 0.25 0.179 0.611762621539 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
I/T 8999 Ig-75 74 rs1281961108 0.0844 -1.926 None N 0.25 0.179 0.611762621539 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 8999 Ig-75 74 rs1281961108 0.0844 -1.926 None N 0.25 0.179 0.611762621539 gnomAD-4.0.0 9.91503E-06 None None None None N None 0 0 None 0 0 None 0 0 1.35619E-05 0 0
I/V 8999 Ig-75 74 rs766374343 0.0655 -1.276 None N 0.129 0.081 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/V 8999 Ig-75 74 rs766374343 0.0655 -1.276 None N 0.129 0.081 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 8999 Ig-75 74 rs766374343 0.0655 -1.276 None N 0.129 0.081 None gnomAD-4.0.0 6.56987E-06 None None None None N None 2.41161E-05 0 None 0 0 None 0 0 0 0 0
I/R 9092 Ig-76 74 None 0.1463 None 0.061 N 0.529 0.292 0.663816143375 gnomAD-4.0.0 3.42104E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49729E-06 0 0
I/V 9092 Ig-76 74 rs1222539429 0.0614 -0.876 None N 0.174 0.103 0.517983797298 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
I/V 9092 Ig-76 74 rs1222539429 0.0614 -0.876 None N 0.174 0.103 0.517983797298 gnomAD-4.0.0 8.21051E-06 None None None None N None 0 2.23644E-05 None 0 5.03905E-05 None 0 0 8.09514E-06 0 0
Y/C 9185 Ig-77 74 rs1477423741 0.0806 -0.97 0.993 N 0.595 0.448 0.635940165184 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
Y/C 9185 Ig-77 74 rs1477423741 0.0806 -0.97 0.993 N 0.595 0.448 0.635940165184 gnomAD-4.0.0 1.59124E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85811E-06 0 0
K/I 9278 Ig-78 74 None 0.3099 None 0.781 N 0.824 0.334 0.529210848824 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 9374 Ig-79 74 rs886038863 0.0951 None 0.826 None 0.538 0.279 0.265929055128 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 9374 Ig-79 74 rs886038863 0.0951 None 0.826 None 0.538 0.279 0.265929055128 gnomAD-4.0.0 5.07447E-06 None None None None N None 0 0 None 0 0 None 0 0 6.0246E-06 0 0
T/I 9374 Ig-79 74 rs878939055 0.1346 None 0.852 None 0.583 0.363 0.444305618086 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/I 9374 Ig-79 74 rs878939055 0.1346 None 0.852 None 0.583 0.363 0.444305618086 gnomAD-4.0.0 1.5917E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85909E-06 0 0
Y/C 9470 Ig-80 74 rs781236320 0.1288 -0.38 0.873 None 0.504 0.374 0.503744809241 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/N 9567 Ig-81 75 rs2076366428 0.8167 None 0.998 None 0.637 0.315 0.236890367714 gnomAD-4.0.0 3.42098E-06 None None None None N None 1.49361E-04 0 None 0 0 None 0 0 0 0 0
K/T 9567 Ig-81 75 rs770062038 0.4419 -1.102 0.998 None 0.707 0.439 0.496957384516 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
V/A 9772 Ig-83 75 None 0.7846 None 0.998 None 0.597 0.473 0.664811939827 gnomAD-4.0.0 6.84163E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99421E-07 0 0
V/E 9772 Ig-83 75 rs1430077040 0.892 -2.79 1.0 None 0.831 0.567 0.836324807194 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/E 9772 Ig-83 75 rs1430077040 0.892 -2.79 1.0 None 0.831 0.567 0.836324807194 gnomAD-4.0.0 6.84163E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
V/M 9772 Ig-83 75 rs563073635 0.5064 -1.093 1.0 None 0.802 0.324 None gnomAD-2.1.1 5.7E-05 None None None None N None 1.6533E-04 2.83E-05 None 0 0 None 0 None 0 8.57E-05 0
V/M 9772 Ig-83 75 rs563073635 0.5064 -1.093 1.0 None 0.802 0.324 None gnomAD-3.1.2 6.57E-05 None None None None N None 1.20732E-04 0 0 0 0 None 0 0 7.35E-05 0 0
V/M 9772 Ig-83 75 rs563073635 0.5064 -1.093 1.0 None 0.802 0.324 None 1000 genomes 3.99361E-04 None None None None N None 8E-04 0 None None 0 1E-03 None None None 0 None
V/M 9772 Ig-83 75 rs563073635 0.5064 -1.093 1.0 None 0.802 0.324 None gnomAD-4.0.0 4.89506E-05 None None None None N None 9.33184E-05 3.33278E-05 None 0 0 None 0 0 5.76352E-05 0 3.20051E-05
K/E 10061 Ig-85 73 rs184153985 0.4037 None 0.64 None 0.551 0.242 0.337868961071 gnomAD-4.0.0 1.36831E-06 None None None None N None 0 0 None 0 5.03804E-05 None 0 0 0 0 0
K/I 10061 Ig-85 73 None 0.4296 None 0.984 None 0.708 0.455 0.563359363175 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/Q 10061 Ig-85 73 rs184153985 0.171 -0.781 0.251 None 0.376 0.14 None gnomAD-2.1.1 1.49662E-04 None None None None N None 1.69422E-03 2.83E-05 None 0 0 None 0 None 0 0 0
K/Q 10061 Ig-85 73 rs184153985 0.171 -0.781 0.251 None 0.376 0.14 None gnomAD-3.1.2 4.59831E-04 None None None None N None 1.66442E-03 6.54E-05 0 0 0 None 0 0 0 0 0
K/Q 10061 Ig-85 73 rs184153985 0.171 -0.781 0.251 None 0.376 0.14 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
K/Q 10061 Ig-85 73 rs184153985 0.171 -0.781 0.251 None 0.376 0.14 None gnomAD-4.0.0 7.43492E-05 None None None None N None 1.51887E-03 6.66378E-05 None 0 0 None 0 0 0 0 3.20051E-05
I/M 10150 Ig-86 73 rs761922521 0.537 -1.531 1.0 None 0.807 0.267 0.580120749226 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/M 10150 Ig-86 73 rs761922521 0.537 -1.531 1.0 None 0.807 0.267 0.580120749226 gnomAD-4.0.0 6.84136E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
I/V 10150 Ig-86 73 None 0.3215 None 0.993 None 0.36 0.277 0.715603600314 gnomAD-4.0.0 2.73654E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79878E-06 2.31863E-05 0
Q/E 14214 Ig-92 73 rs1188613689 0.088 -0.177 None N 0.14 0.162 0.28297238246 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
Q/E 14214 Ig-92 73 rs1188613689 0.088 -0.177 None N 0.14 0.162 0.28297238246 gnomAD-4.0.0 2.73757E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69882E-06 0 1.65717E-05
Q/P 14214 Ig-92 73 None 0.9318 None 0.662 N 0.514 0.366 0.367612772649 gnomAD-4.0.0 2.73803E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59924E-06 0 0
D/G 14302 Ig-93 72 None 0.585 None 0.955 D 0.7 0.373 0.403609169532 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 14302 Ig-93 72 None 0.1387 None 0.977 N 0.733 0.292 0.347659731818 gnomAD-4.0.0 1.59235E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
Q/E 14391 Ig-94 73 rs768592399 0.1066 -0.22 0.951 N 0.586 0.189 0.167679373172 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
Q/E 14391 Ig-94 73 rs768592399 0.1066 -0.22 0.951 N 0.586 0.189 0.167679373172 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/E 14391 Ig-94 73 rs768592399 0.1066 -0.22 0.951 N 0.586 0.189 0.167679373172 gnomAD-4.0.0 7.43915E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47861E-06 0 3.20349E-05
Q/H 14391 Ig-94 73 rs1206302591 0.4019 -1.014 0.998 N 0.572 0.188 0.144782658237 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/H 14391 Ig-94 73 rs1206302591 0.4019 -1.014 0.998 N 0.572 0.188 0.144782658237 gnomAD-4.0.0 1.59261E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43382E-05 0
E/A 14480 Ig-95 73 None 0.3452 None 0.999 N 0.707 0.405 0.508934680445 gnomAD-4.0.0 6.84385E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99624E-07 0 0
E/G 14480 Ig-95 73 rs1449008181 0.6217 -1.594 1.0 D 0.795 0.504 0.64458063076 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/G 14480 Ig-95 73 rs1449008181 0.6217 -1.594 1.0 D 0.795 0.504 0.64458063076 gnomAD-4.0.0 2.05315E-06 None None None None N None 0 2.23694E-05 None 0 0 None 0 0 8.99624E-07 0 1.65761E-05
E/D 14569 Ig-96 73 rs1262651823 0.4216 None 0.999 D 0.553 0.323 0.29527378943 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 14569 Ig-96 73 rs1262651823 0.4216 None 0.999 D 0.553 0.323 0.29527378943 gnomAD-4.0.0 3.10798E-06 None None None None N None 0 0 None 0 0 None 0 0 4.24657E-06 0 0
D/G 14658 Ig-97 73 rs574681280 0.5414 -1.304 0.989 D 0.625 0.349 0.424670345773 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 1.63527E-04 None 0 0 0
D/G 14658 Ig-97 73 rs574681280 0.5414 -1.304 0.989 D 0.625 0.349 0.424670345773 gnomAD-4.0.0 4.79094E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.95862E-05 1.65739E-05
D/N 14658 Ig-97 73 rs1397760858 0.1568 None 0.989 N 0.625 0.305 0.426670027402 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/N 14658 Ig-97 73 rs1397760858 0.1568 None 0.989 N 0.625 0.305 0.426670027402 gnomAD-4.0.0 6.57479E-06 None None None None N None 0 6.55136E-05 None 0 0 None 0 0 0 0 0
D/V 14658 Ig-97 73 None 0.337 None 0.998 N 0.805 0.448 0.585593966701 gnomAD-4.0.0 2.73768E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69882E-06 0 1.65739E-05
T/A 14836 Ig-99 72 rs761382291 0.0984 -1.377 0.027 N 0.53 0.1 0.19670166235 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
T/A 14836 Ig-99 72 rs761382291 0.0984 -1.377 0.027 N 0.53 0.1 0.19670166235 gnomAD-4.0.0 6.00167E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56258E-06 0 0
D/G 14925 Ig-100 73 rs775846804 0.5171 -1.352 0.217 N 0.414 0.327 0.270447802918 gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 0 None 2.28863E-04 None 0 0 0
D/G 14925 Ig-100 73 rs775846804 0.5171 -1.352 0.217 N 0.414 0.327 0.270447802918 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.13907E-04 0
D/G 14925 Ig-100 73 rs775846804 0.5171 -1.352 0.217 N 0.414 0.327 0.270447802918 gnomAD-4.0.0 8.68114E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.53765E-04 0
R/G 15103 Ig-102 73 None 0.4121 None 0.956 D 0.685 0.394 0.582989276457 gnomAD-4.0.0 6.84742E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99952E-07 0 0
R/L 15103 Ig-102 73 rs771113343 0.2425 None 0.956 N 0.685 0.331 0.610115391599 gnomAD-4.0.0 1.5941E-06 None None None None N None 0 0 None 0 2.78505E-05 None 0 0 0 0 0
R/Q 15103 Ig-102 73 rs771113343 0.0998 -0.45 0.994 N 0.693 0.235 0.24896430686 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
R/Q 15103 Ig-102 73 rs771113343 0.0998 -0.45 0.994 N 0.693 0.235 0.24896430686 gnomAD-3.1.2 1.32E-05 None None None None N None 4.84E-05 0 0 0 0 None 0 0 0 0 0
R/Q 15103 Ig-102 73 rs771113343 0.0998 -0.45 0.994 N 0.693 0.235 0.24896430686 gnomAD-4.0.0 5.13373E-06 None None None None N None 5.0863E-05 0 None 0 0 None 0 0 2.39707E-06 0 0
M/I 15192 Ig-103 73 rs1559876731 0.4117 None 0.028 N 0.249 0.177 0.694280915357 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
M/I 15192 Ig-103 73 rs1559876731 0.4117 None 0.028 N 0.249 0.177 0.694280915357 gnomAD-4.0.0 1.59375E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86161E-06 0 0
M/T 15192 Ig-103 73 None 0.1784 None 0.028 N 0.252 0.168 0.752934275728 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 15280 Ig-104 73 rs763279178 0.1432 -0.535 0.927 D 0.738 0.315 0.587992605178 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
S/F 15280 Ig-104 73 rs763279178 0.1432 -0.535 0.927 D 0.738 0.315 0.587992605178 gnomAD-4.0.0 3.18677E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72567E-06 0 0
T/A 15374 Ig-105 73 rs1313103090 0.1102 None 0.024 N 0.431 0.09 0.236278675362 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 15374 Ig-105 73 rs1313103090 0.1102 None 0.024 N 0.431 0.09 0.236278675362 gnomAD-4.0.0 6.58293E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47267E-05 0 0
G/R 15463 Ig-106 73 rs200042932 0.744 -0.506 1.0 N 0.898 0.496 0.730639839714 gnomAD-2.1.1 2.98514E-04 None None None None N None 3.31565E-04 5.69E-05 None 1.94477E-04 5.2E-05 None 3.27E-05 None 1.60295E-04 5.05338E-04 1.41363E-04
G/R 15463 Ig-106 73 rs200042932 0.744 -0.506 1.0 N 0.898 0.496 0.730639839714 gnomAD-3.1.2 2.63584E-04 None None None None N None 3.14374E-04 0 0 0 1.95008E-04 None 9.43E-05 0 3.38913E-04 4.14766E-04 0
G/R 15463 Ig-106 73 rs200042932 0.744 -0.506 1.0 N 0.898 0.496 0.730639839714 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
G/R 15463 Ig-106 73 rs200042932 0.744 -0.506 1.0 N 0.898 0.496 0.730639839714 gnomAD-4.0.0 2.73992E-06 None None None None N None 0 0 None 0 0 None 0 0 3.6007E-06 0 0
I/T 15552 Ig-107 73 rs1292128337 0.2084 -2.11 0.822 N 0.678 0.285 0.675543170505 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
I/T 15552 Ig-107 73 rs1292128337 0.2084 -2.11 0.822 N 0.678 0.285 0.675543170505 gnomAD-4.0.0 3.18972E-06 None None None None N None 0 0 None 0 0 None 0 2.42365E-04 2.86513E-06 0 0
K/Q 16036 Ig-109 69 rs886055271 0.1005 None None N 0.246 0.14 0.203808441222 gnomAD-4.0.0 4.79216E-06 None None None None N None 0 0 None 0 2.5236E-05 None 0 0 8.99865E-07 0 8.29105E-05
E/K 16332 Ig-110 71 rs879092258 0.8058 None 0.999 N 0.675 0.446 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 16332 Ig-110 71 rs879092258 0.8058 None 0.999 N 0.675 0.446 None gnomAD-4.0.0 2.56733E-06 None None None None I None 0 0 None 0 0 None 0 0 4.79393E-06 0 0
T/I 17028 Ig-111 74 rs1403894865 0.1987 -0.13 0.013 N 0.459 0.291 0.32053947749 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/R 17350 Ig-112 100 rs545725664 0.0934 -1.141 0.026 N 0.433 0.111 0.369682402691 gnomAD-2.1.1 5.25E-05 None None None None N None 0 4.19E-05 None 0 0 None 0 None 0 9.79E-05 0
K/R 17350 Ig-112 100 rs545725664 0.0934 -1.141 0.026 N 0.433 0.111 0.369682402691 gnomAD-4.0.0 1.2239E-05 None None None None N None 0 3.04971E-05 None 0 0 None 0 0 1.48099E-05 0 0
K/T 17350 Ig-112 100 None 0.1355 None 0.984 N 0.711 0.386 0.392855499163 gnomAD-4.0.0 7.19939E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.74984E-05
T/I 17745 Ig-113 69 rs879245504 0.3275 None 0.988 N 0.669 0.46 None gnomAD-4.0.0 1.36887E-06 None None None None N None 2.99097E-05 0 None 0 2.5227E-05 None 0 0 0 0 0
T/K 17745 Ig-113 69 rs879245504 0.2955 -0.418 0.852 D 0.6 0.435 0.542053899377 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/K 17745 Ig-113 69 rs879245504 0.2955 -0.418 0.852 D 0.6 0.435 0.542053899377 gnomAD-4.0.0 6.84435E-07 None None None None N None 0 2.23694E-05 None 0 0 None 0 0 0 0 0
T/N 18046 Ig-114 79 None 0.2144 None 0.934 D 0.558 0.251 0.485991781493 gnomAD-4.0.0 1.3714E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.3271E-05 0
T/S 18046 Ig-114 79 None 0.1582 None 0.136 N 0.407 0.184 0.212008924253 gnomAD-4.0.0 2.05709E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80216E-06 1.16355E-05 0
T/A 18460 Ig-115 79 rs727503600 0.1322 -0.714 0.999 N 0.584 0.493 0.41219620536 gnomAD-2.1.1 6.52E-05 None None None None N None 0 2.88401E-04 None 9.88E-05 0 None 0 None 0 4.73E-05 1.42369E-04
T/A 18460 Ig-115 79 rs727503600 0.1322 -0.714 0.999 N 0.584 0.493 0.41219620536 gnomAD-3.1.2 1.11794E-04 None None None None N None 0 9.83736E-04 0 0 0 None 0 0 1.47E-05 0 4.78011E-04
T/A 18460 Ig-115 79 rs727503600 0.1322 -0.714 0.999 N 0.584 0.493 0.41219620536 gnomAD-4.0.0 6.58568E-05 None None None None N None 0 5.05663E-04 None 3.39951E-05 0 None 0 0 5.09078E-05 0 2.4091E-04
T/I 18460 Ig-115 79 rs372778818 0.1558 0.085 1.0 D 0.863 0.477 None gnomAD-2.1.1 7.97E-05 None None None None N None 8.71442E-04 2.88E-05 None 0 0 None 0 None 0 0 0
T/I 18460 Ig-115 79 rs372778818 0.1558 0.085 1.0 D 0.863 0.477 None gnomAD-3.1.2 1.84223E-04 None None None None N None 6.03544E-04 1.96876E-04 0 0 0 None 0 0 0 0 0
T/I 18460 Ig-115 79 rs372778818 0.1558 0.085 1.0 D 0.863 0.477 None 1000 genomes 3.99361E-04 None None None None N None 8E-04 1.4E-03 None None 0 0 None None None 0 None
T/I 18460 Ig-115 79 rs372778818 0.1558 0.085 1.0 D 0.863 0.477 None gnomAD-4.0.0 3.66573E-05 None None None None N None 6.55869E-04 1.01136E-04 None 0 0 None 0 0 0 0 6.42281E-05
V/I 19460 Ig-118 70 rs770096744 0.0708 -0.238 None N 0.261 0.102 0.214338557667 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 19460 Ig-118 70 rs770096744 0.0708 -0.238 None N 0.261 0.102 0.214338557667 gnomAD-4.0.0 3.18339E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.8659E-05 0
T/I 19858 Ig-119 69 rs757911359 0.2179 -0.013 1.0 D 0.871 0.445 0.562807121957 gnomAD-2.1.1 7.66E-05 None None None None N None 0 0 None 0 0 None 6.21199E-04 None 0 0 0
T/I 19858 Ig-119 69 rs757911359 0.2179 -0.013 1.0 D 0.871 0.445 0.562807121957 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.13907E-04 0
T/I 19858 Ig-119 69 rs757911359 0.2179 -0.013 1.0 D 0.871 0.445 0.562807121957 gnomAD-4.0.0 4.27689E-05 None None None None N None 0 0 None 0 0 None 0 0 0 7.35811E-04 3.20287E-05
T/K 19858 Ig-119 69 None 0.2794 None 1.0 D 0.86 0.498 0.536709800451 gnomAD-4.0.0 6.84349E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65689E-05
T/R 19858 Ig-119 69 rs757911359 0.2322 None 1.0 D 0.872 0.513 0.612832922585 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/R 19858 Ig-119 69 rs757911359 0.2322 None 1.0 D 0.872 0.513 0.612832922585 gnomAD-4.0.0 1.85952E-06 None None None None N None 2.67044E-05 0 None 0 0 None 0 0 8.47754E-07 0 0
T/A 20152 Ig-120 73 None 0.0921 None 0.999 N 0.601 0.484 0.51230852224 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 20152 Ig-120 73 rs2050136717 0.1478 None 1.0 N 0.875 0.416 0.744318758753 gnomAD-4.0.0 7.5287E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99679E-06 0 1.65706E-05
S/L 20550 Ig-121 72 rs2049883330 0.081 None 0.001 N 0.423 0.188 0.428401797576 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/L 20550 Ig-121 72 rs2049883330 0.081 None 0.001 N 0.423 0.188 0.428401797576 gnomAD-4.0.0 6.57704E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47111E-05 0 0
T/K 20845 Ig-122 77 None 0.263 None 1.0 N 0.853 0.467 0.515490261806 gnomAD-4.0.0 6.84314E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65678E-05
T/M 20845 Ig-122 77 rs727505316 0.1005 -0.167 1.0 D 0.827 0.433 0.624018827985 gnomAD-2.1.1 5.63E-05 None None None None N None 0 0 None 0 0 None 2.94214E-04 None 0 4.44E-05 0
T/M 20845 Ig-122 77 rs727505316 0.1005 -0.167 1.0 D 0.827 0.433 0.624018827985 gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 4.14422E-04 0
T/M 20845 Ig-122 77 rs727505316 0.1005 -0.167 1.0 D 0.827 0.433 0.624018827985 gnomAD-4.0.0 4.46271E-05 None None None None N None 1.33522E-05 0 None 0 2.23354E-05 None 0 0 3.39087E-05 3.18422E-04 1.60138E-05
T/R 20845 Ig-122 77 rs727505316 0.2316 -0.503 1.0 N 0.853 0.486 0.595214673487 gnomAD-2.1.1 4.29E-05 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 7.03E-05 1.40489E-04
T/R 20845 Ig-122 77 rs727505316 0.2316 -0.503 1.0 N 0.853 0.486 0.595214673487 gnomAD-3.1.2 6.58E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 8.83E-05 0 4.78927E-04
T/R 20845 Ig-122 77 rs727505316 0.2316 -0.503 1.0 N 0.853 0.486 0.595214673487 gnomAD-4.0.0 2.97514E-05 None None None None N None 4.00566E-05 0 None 0 0 None 0 0 3.56041E-05 0 4.80415E-05
T/A 21247 Ig-123 71 None 0.1461 None 0.489 N 0.621 0.297 0.374613414588 gnomAD-4.0.0 1.59453E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86226E-06 0 0
T/I 21540 Ig-124 72 rs1284135964 0.1078 0.51 0.012 N 0.446 0.179 0.29132392195 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/I 21540 Ig-124 72 rs1284135964 0.1078 0.51 0.012 N 0.446 0.179 0.29132392195 gnomAD-4.0.0 1.36907E-06 None None None None N None 0 2.23884E-05 None 0 0 None 0 0 8.99816E-07 0 0
T/R 21540 Ig-124 72 None 0.186 None 0.966 N 0.683 0.333 0.441740949975 gnomAD-4.0.0 6.84537E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1606E-05 0
T/A 21937 Ig-125 72 rs969062428 0.1171 None 0.76 N 0.625 0.214 0.324436698001 gnomAD-4.0.0 1.70846E-06 None None None None N None 0 2.51813E-05 None 0 0 None 0 0 0 0 0
T/I 22335 Ig-126 71 None 0.1578 None 0.82 N 0.645 0.174 0.40318662893 gnomAD-4.0.0 1.59251E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86064E-06 0 0
T/I 22624 Ig-127 65 None 0.1266 None 0.007 N 0.513 0.29 0.317084106153 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8599E-06 0 0
T/K 22624 Ig-127 65 rs761798459 0.3251 -0.637 0.213 N 0.654 0.3 0.3349148499 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/K 22624 Ig-127 65 rs761798459 0.3251 -0.637 0.213 N 0.654 0.3 0.3349148499 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8599E-06 0 0
T/I 23021 Ig-128 72 rs1559469943 0.1783 None 0.989 N 0.849 0.384 0.524894780827 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/I 23021 Ig-128 72 rs1559469943 0.1783 None 0.989 N 0.849 0.384 0.524894780827 gnomAD-4.0.0 6.8443E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99633E-07 0 0
T/P 23021 Ig-128 72 None 0.8641 None 0.989 D 0.849 0.662 0.589546583947 gnomAD-4.0.0 1.59245E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85994E-06 0 0
T/N 23416 Ig-129 72 rs762398059 0.1145 -1.352 0.989 N 0.609 0.308 0.486920840936 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/N 23416 Ig-129 72 rs762398059 0.1145 -1.352 0.989 N 0.609 0.308 0.486920840936 gnomAD-4.0.0 1.59168E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
T/I 23707 Ig-130 71 None 0.0907 None 0.984 N 0.753 0.337 0.491729458163 gnomAD-4.0.0 1.20033E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/R 23707 Ig-130 71 rs1180389290 0.1548 -0.561 0.938 N 0.717 0.411 0.606211627851 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/R 23707 Ig-130 71 rs1180389290 0.1548 -0.561 0.938 N 0.717 0.411 0.606211627851 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 23707 Ig-130 71 rs1180389290 0.1548 -0.561 0.938 N 0.717 0.411 0.606211627851 gnomAD-4.0.0 6.57497E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47072E-05 0 0
T/I 24103 Ig-131 75 rs758801815 0.1221 0.087 0.993 D 0.791 0.438 0.53911333632 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 24103 Ig-131 75 rs758801815 0.1221 0.087 0.993 D 0.791 0.438 0.53911333632 gnomAD-4.0.0 1.36996E-06 None None None None N None 2.99294E-05 0 None 0 0 None 0 0 9.00328E-07 0 0
T/R 24103 Ig-131 75 None 0.1466 None 0.997 N 0.805 0.469 0.664903063441 gnomAD-4.0.0 6.84978E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16198E-05 0
K/E 24789 Ig-133 74 rs374382352 0.1774 -0.884 0.892 N 0.573 0.396 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
K/T 25185 Ig-134 75 rs371042435 0.0946 -1.442 0.001 N 0.288 0.228 None gnomAD-2.1.1 1.08826E-04 None None None None N None 6.46E-05 0 None 0 0 None 8.4984E-04 None 0 0 0
K/T 25185 Ig-134 75 rs371042435 0.0946 -1.442 0.001 N 0.288 0.228 None gnomAD-3.1.2 3.29E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 4.14079E-04 0
K/T 25185 Ig-134 75 rs371042435 0.0946 -1.442 0.001 N 0.288 0.228 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/T 25185 Ig-134 75 rs371042435 0.0946 -1.442 0.001 N 0.288 0.228 None gnomAD-4.0.0 3.96671E-05 None None None None N None 3.99957E-05 0 None 0 0 None 0 0 0 6.6977E-04 0
T/I 25871 Ig-136 74 None 0.1094 None 0.001 N 0.451 0.146 0.193865811164 gnomAD-4.0.0 1.592E-06 None None None None N None 0 0 None 0 0 None 1.88296E-05 0 0 0 0
R/K 26267 Ig-137 75 None 0.0655 None 0.048 N 0.291 0.134 0.194818534648 gnomAD-4.0.0 1.37705E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80407E-06 0 0
R/S 26267 Ig-137 75 rs1373203200 0.3961 None 0.104 N 0.393 0.385 0.280987212366 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 26267 Ig-137 75 rs1373203200 0.3961 None 0.104 N 0.393 0.385 0.280987212366 gnomAD-4.0.0 6.57454E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47102E-05 0 0
T/M 26953 Ig-139 74 rs377506142 0.0815 0.069 0.509 N 0.507 0.301 0.594056560588 gnomAD-2.1.1 8.19021E-04 None None None None N None 0 0 None 0 0 None 7.15827E-03 None 0 2.35E-05 9.83146E-04
T/M 26953 Ig-139 74 rs377506142 0.0815 0.069 0.509 N 0.507 0.301 0.594056560588 gnomAD-3.1.2 2.43367E-04 None None None None N None 2.41E-05 0 0 0 1.93274E-04 None 0 0 1.47E-05 7.04225E-03 0
T/M 26953 Ig-139 74 rs377506142 0.0815 0.069 0.509 N 0.507 0.301 0.594056560588 1000 genomes 1.59744E-03 None None None None N None 0 0 None None 0 0 None None None 8.2E-03 None
T/M 26953 Ig-139 74 rs377506142 0.0815 0.069 0.509 N 0.507 0.301 0.594056560588 gnomAD-4.0.0 4.00976E-04 None None None None N None 3.99989E-05 0 None 0 2.23045E-05 None 0 0 1.18677E-05 6.56623E-03 4.96318E-04
T/R 26953 Ig-139 74 rs377506142 0.1372 -0.048 0.959 D 0.731 0.441 0.650727440417 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/R 26953 Ig-139 74 rs377506142 0.1372 -0.048 0.959 D 0.731 0.441 0.650727440417 gnomAD-4.0.0 3.42134E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49768E-06 0 0
K/Q 27350 Ig-140 73 None 0.0819 None 0.007 N 0.324 0.142 0.206339911435 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85843E-06 0 0
T/I 28431 Ig-143 74 rs780326294 0.1754 -0.142 1.0 N 0.849 0.455 0.586235444834 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 29118 Ig-145 74 None 0.0971 None 0.998 N 0.565 0.468 0.397838977388 gnomAD-4.0.0 1.20032E-05 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-05 0 0
T/I 29118 Ig-145 74 rs1342749098 0.123 0.014 0.884 N 0.386 0.363 0.556733452047 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/P 29118 Ig-145 74 rs767023377 0.771 -0.624 1.0 N 0.813 0.651 0.689816159312 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 1.53704E-04 None 0 None 0 0 0
T/P 29118 Ig-145 74 rs767023377 0.771 -0.624 1.0 N 0.813 0.651 0.689816159312 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.85654E-04 None 0 0 0 0 0
T/P 29118 Ig-145 74 rs767023377 0.771 -0.624 1.0 N 0.813 0.651 0.689816159312 gnomAD-4.0.0 3.04478E-06 None None None None N None 0 0 None 0 3.4029E-04 None 0 0 0 0 0
T/I 29913 Ig-147 72 rs1222720970 0.1941 -0.074 0.998 D 0.735 0.435 0.627088449377 gnomAD-2.1.1 1.21E-05 None None None None N None 1.29182E-04 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 29913 Ig-147 72 rs1222720970 0.1941 -0.074 0.998 D 0.735 0.435 0.627088449377 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 29913 Ig-147 72 rs1222720970 0.1941 -0.074 0.998 D 0.735 0.435 0.627088449377 gnomAD-4.0.0 8.67716E-06 None None None None N None 4.0032E-05 0 None 0 0 None 0 0 9.32567E-06 0 0
T/R 29913 Ig-147 72 None 0.2311 None 0.989 D 0.704 0.467 0.733834204116 gnomAD-4.0.0 1.36872E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31911E-05 0
I/N 30205 Ig-148 74 rs1283032526 0.5542 -1.9 0.998 D 0.811 0.521 0.838418281918 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/N 30205 Ig-148 74 rs1283032526 0.5542 -1.9 0.998 D 0.811 0.521 0.838418281918 gnomAD-4.0.0 3.18458E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7187E-06 0 0
E/G 30600 Ig-149 69 None 0.3895 None 1.0 N 0.821 0.544 0.633985563651 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 30997 Ig-150 71 rs981213729 0.1301 -0.298 0.782 D 0.734 0.315 0.491387584038 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/I 30997 Ig-150 71 rs981213729 0.1301 -0.298 0.782 D 0.734 0.315 0.491387584038 gnomAD-4.0.0 6.15764E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29613E-06 2.31863E-05 0
T/I 31289 Ig-151 72 None 0.1435 None 0.978 N 0.75 0.319 0.451504584351 gnomAD-4.0.0 6.84167E-07 None None None None N None 2.98793E-05 0 None 0 0 None 0 0 0 0 0
T/N 31289 Ig-151 72 rs371666313 0.1867 -1.335 0.997 D 0.727 0.347 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/N 31289 Ig-151 72 rs371666313 0.1867 -1.335 0.997 D 0.727 0.347 None gnomAD-4.0.0 1.85897E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54267E-06 0 0
E/K 32086 Ig-153 70 rs775945524 0.1641 -0.264 0.999 N 0.669 0.442 0.406945738958 gnomAD-2.1.1 8.05E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.89E-06 0
E/K 32086 Ig-153 70 rs775945524 0.1641 -0.264 0.999 N 0.669 0.442 0.406945738958 gnomAD-4.0.0 3.18303E-06 None None None None N None 5.65867E-05 0 None 0 0 None 0 0 2.85886E-06 0 0
E/A 32380 Ig-154 74 None 0.2553 None 0.996 N 0.665 0.536 0.45553875121 gnomAD-4.0.0 3.42106E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49742E-06 0 0
V/L 32776 Ig-155 69 None 0.1249 None 0.009 N 0.527 0.184 0.42538462244 gnomAD-4.0.0 1.08029E-05 None None None None N None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
I/T 33174 Ig-156 74 rs879116103 0.1178 -2.194 None N 0.277 0.086 None gnomAD-2.1.1 1.43E-05 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 1.56E-05 0
I/T 33174 Ig-156 74 rs879116103 0.1178 -2.194 None N 0.277 0.086 None gnomAD-3.1.2 3.29E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 33174 Ig-156 74 rs879116103 0.1178 -2.194 None N 0.277 0.086 None gnomAD-4.0.0 6.197E-06 None None None None N None 5.3396E-05 0 None 0 0 None 0 0 5.08571E-06 0 0
Q/H 33271 Ig-157 69 rs1201464356 0.5197 -1.243 1.0 N 0.646 0.326 0.257786959452 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.03E-06 0
Q/H 33271 Ig-157 69 rs1201464356 0.5197 -1.243 1.0 N 0.646 0.326 0.257786959452 gnomAD-4.0.0 1.61262E-06 None None None None I None 0 0 None 0 0 None 0 0 2.90539E-06 0 0
Q/P 33271 Ig-157 69 rs1262109870 0.9882 -0.544 1.0 N 0.747 0.496 0.471211772063 gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.01E-06 0
Q/P 33271 Ig-157 69 rs1262109870 0.9882 -0.544 1.0 N 0.747 0.496 0.471211772063 gnomAD-4.0.0 1.61091E-06 None None None None I None 0 0 None 0 0 None 0 0 2.90256E-06 0 0
C/Y 33670 Ig-159 75 rs749219080 0.8369 -1.7 1.0 N 0.749 0.334 0.720504425005 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
C/Y 33670 Ig-159 75 rs749219080 0.8369 -1.7 1.0 N 0.749 0.334 0.720504425005 gnomAD-4.0.0 2.73678E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59781E-06 0 0
K/N 34210 Ig-160 74 None 0.9342 None 1.0 D 0.814 0.38 0.280987212366 gnomAD-4.0.0 1.59104E-06 None None None None N None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
V/E 34334 Ig-161 77 None 0.4711 None 0.549 N 0.655 0.399 0.759655384941 gnomAD-4.0.0 4.77297E-06 None None None None N None 0 0 None 0 0 None 0 0 8.573E-06 0 0
V/G 34334 Ig-161 77 rs760991295 0.6111 -2.527 0.004 N 0.553 0.374 0.737734676174 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/G 34334 Ig-161 77 rs760991295 0.6111 -2.527 0.004 N 0.553 0.374 0.737734676174 gnomAD-4.0.0 1.59099E-06 None None None None N None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
T/I 34437 Ig-162 75 None 0.4992 None 1.0 N 0.861 0.45 0.613554143916 gnomAD-4.0.0 1.59101E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85763E-06 0 0
T/P 34437 Ig-162 75 rs762313504 0.9687 -0.728 1.0 N 0.852 0.665 0.68404209341 gnomAD-4.0.0 4.77395E-06 None None None None N None 0 0 None 0 0 None 5.65846E-05 0 0 0 0
V/A 35015 Ig-163 74 None 0.4183 None 0.896 D 0.608 0.356 0.557481709393 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85755E-06 0 0
V/M 35202 Ig-164 74 None 0.139 None 0.969 N 0.808 0.326 0.637791279193 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 35360 Ig-165 75 None 0.5386 None 0.999 N 0.648 0.194 0.299770980665 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 35360 Ig-165 75 None 0.2629 None 1.0 N 0.753 0.17 0.293502639404 gnomAD-4.0.0 2.05243E-06 None None None None N None 0 0 None 0 7.55706E-05 None 0 0 0 0 0
I/K 35678 Ig-167 72 rs1558969484 0.5552 None 0.042 N 0.556 0.279 0.647793681525 gnomAD-2.1.1 4.03E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
I/K 35678 Ig-167 72 rs1558969484 0.5552 None 0.042 N 0.556 0.279 0.647793681525 gnomAD-4.0.0 2.73723E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59807E-06 0 0
I/M 35678 Ig-167 72 None 0.1783 None 0.427 N 0.554 0.123 0.213573922156 gnomAD-4.0.0 1.59179E-06 None None None None N None 0 0 None 0 2.77377E-05 None 0 0 0 0 0
I/T 35678 Ig-167 72 None 0.3311 None 0.081 N 0.52 0.25 0.524998368707 gnomAD-4.0.0 6.84307E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
I/V 35678 Ig-167 72 rs1404746485 0.1205 -1.209 None N 0.176 0.088 0.461759001683 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/V 35678 Ig-167 72 rs1404746485 0.1205 -1.209 None N 0.176 0.088 0.461759001683 gnomAD-4.0.0 1.59176E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85878E-06 0 0
S/I 35972 Ig-169 76 rs397517478 0.1617 -0.108 0.213 N 0.607 0.245 None gnomAD-2.1.1 7.85E-05 None None None -0.652(OBSL1) -0.28(OBSCN) N None 4.13E-05 0 None 0 5.12E-05 None 9.81E-05 None 0 1.01311E-04 5.6164E-04
S/I 35972 Ig-169 76 rs397517478 0.1617 -0.108 0.213 N 0.607 0.245 None gnomAD-3.1.2 1.18304E-04 None None None -0.652(OBSL1) -0.28(OBSCN) N None 2.41E-05 0 0 0 1.92308E-04 None 0 0 2.35218E-04 0 0
S/I 35972 Ig-169 76 rs397517478 0.1617 -0.108 0.213 N 0.607 0.245 None gnomAD-4.0.0 7.93177E-05 None None None -0.652(OBSL1) -0.28(OBSCN) N None 4.00449E-05 0 None 0 2.22747E-05 None 0 2.30112E-03 6.69577E-05 2.41562E-04 1.44078E-04
S/N 35972 Ig-169 76 None 0.1532 None 0.001 N 0.197 0.103 0.193865811164 gnomAD-4.0.0 6.84175E-07 None None None -0.447(OBSL1) -0.887(OBSCN) N None 0 0 None 0 0 None 0 0 8.9942E-07 0 0
S/R 35972 Ig-169 76 None 0.3594 None 0.101 N 0.471 0.222 0.200317383148 gnomAD-4.0.0 1.20033E-06 None None None -1.147(OBSL1) -0.943(OBSCN) N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.