TITINdb

Map SAVs to Structure

Position	Domain position	SAV	Structural Position	RS	Q(SASA)	Disease	Source	MAF
31409	2	P/Q	2	None	0.1208	None	gnomAD-4.0.0	2.40065E-06
31409	2	P/S	2	rs1464695009	0.1208	None	gnomAD-2.1.1	1.24E-05
31409	2	P/S	2	rs1464695009	0.1208	None	gnomAD-4.0.0	8.07935E-06
31411	4	A/T	4	rs745652405	0.2303	None	gnomAD-2.1.1	4.01E-05
31411	4	A/T	4	rs745652405	0.2303	None	gnomAD-3.1.2	1.97E-05
31411	4	A/T	4	rs745652405	0.2303	None	gnomAD-4.0.0	1.68125E-05
31412	5	P/A	5	rs757361681	0.1236	None	gnomAD-2.1.1	4.07E-06
31412	5	P/A	5	rs757361681	0.1236	None	gnomAD-4.0.0	1.37288E-06
31412	5	P/L	5	rs1454161350	0.1236	None	gnomAD-2.1.1	3.19E-05
31412	5	P/L	5	rs1454161350	0.1236	None	gnomAD-3.1.2	6.57E-06
31412	5	P/L	5	rs1454161350	0.1236	None	gnomAD-4.0.0	2.57798E-06
31412	5	P/S	5	rs757361681	0.1236	None	gnomAD-2.1.1	4.07E-06
31412	5	P/S	5	rs757361681	0.1236	None	gnomAD-4.0.0	6.86442E-07
31413	6	T/A	6	rs1361033922	0.3578	None	gnomAD-2.1.1	4.06E-06
31413	6	T/A	6	rs1361033922	0.3578	None	gnomAD-4.0.0	2.7443E-06
31414	7	R/G	7	rs369418580	0.3067	None	gnomAD-2.1.1	1.8E-05
31414	7	R/G	7	rs369418580	0.3067	None	gnomAD-3.1.2	1.97E-05
31414	7	R/G	7	rs369418580	0.3067	None	gnomAD-4.0.0	1.80127E-05
31415	8	P/L	9	rs756168192	0.1342	None	gnomAD-2.1.1	4.04E-06
31415	8	P/L	9	rs756168192	0.1342	None	gnomAD-4.0.0	1.59585E-06
31417	10	V/A	12	rs878947167	0.2409	None	gnomAD-2.1.1	4.03E-06
31417	10	V/A	12	rs878947167	0.2409	None	gnomAD-4.0.0	5.47692E-06
31417	10	V/I	12	rs1188866872	0.2409	None	gnomAD-3.1.2	6.57E-06
31417	10	V/I	12	rs1188866872	0.2409	None	gnomAD-4.0.0	6.57333E-06
31420	13	V/M	15	rs1697609809	0.2480	None	gnomAD-4.0.0	6.84396E-07
31422	15	A/P	17	rs755395347	0.1359	None	gnomAD-2.1.1	4.03E-06
31422	15	A/P	17	rs755395347	0.1359	None	gnomAD-4.0.0	1.59183E-06
31422	15	A/V	17	None	0.1359	None	gnomAD-4.0.0	1.59161E-06
31423	16	N/H	18	rs751814511	0.5761	None	gnomAD-2.1.1	4.02E-06
31423	16	N/H	18	rs751814511	0.5761	None	gnomAD-4.0.0	1.59153E-06
31423	16	N/K	18	rs1387191410	0.5761	None	gnomAD-2.1.1	4.02E-06
31423	16	N/K	18	rs1387191410	0.5761	None	gnomAD-4.0.0	1.59148E-06
31424	17	A/P	19	None	0.1413	None	gnomAD-4.0.0	1.59158E-06
31424	17	A/V	19	rs1178719189	0.1413	None	gnomAD-4.0.0	1.20033E-06
31425	18	M/I	20	None	0.0799	None	gnomAD-4.0.0	1.20032E-06
31425	18	M/K	20	rs764947983	0.0799	None	gnomAD-2.1.1	3.18E-05
31425	18	M/K	20	rs764947983	0.0799	None	gnomAD-3.1.2	6.57E-06
31425	18	M/K	20	rs764947983	0.0799	None	gnomAD-4.0.0	2.56218E-06
31425	18	M/T	20	rs764947983	0.0799	None	gnomAD-2.1.1	4.02E-06
31425	18	M/T	20	rs764947983	0.0799	None	gnomAD-4.0.0	1.59138E-06
31426	19	S/F	21	rs369284856	0.1202	None	gnomAD-2.1.1	8.05E-06
31426	19	S/F	21	rs369284856	0.1202	None	gnomAD-3.1.2	6.57E-06
31426	19	S/F	21	rs369284856	0.1202	None	gnomAD-4.0.0	2.56221E-06
31427	20	I/L	22	rs776226409	0.0772	None	gnomAD-2.1.1	8.04E-06
31427	20	I/L	22	rs776226409	0.0772	None	gnomAD-4.0.0	4.10533E-06
31427	20	I/V	22	None	0.0772	None	gnomAD-4.0.0	6.84222E-07
31428	21	R/C	23	rs190282707	0.4449	None	gnomAD-2.1.1	2.5E-05
31428	21	R/C	23	rs190282707	0.4449	None	gnomAD-3.1.2	3.94E-05
31428	21	R/C	23	rs190282707	0.4449	None	gnomAD-4.0.0	1.05344E-05
31428	21	R/G	23	rs190282707	0.4449	None	gnomAD-2.1.1	1.07135E-04
31428	21	R/G	23	rs190282707	0.4449	None	gnomAD-3.1.2	2.76051E-04
31428	21	R/G	23	rs190282707	0.4449	None	gnomAD-4.0.0	4.52359E-05
31428	21	R/H	23	rs149375775	0.4449	None	gnomAD-2.1.1	2.78548E-04
31428	21	R/H	23	rs149375775	0.4449	None	gnomAD-3.1.2	8.74011E-04
31428	21	R/H	23	rs149375775	0.4449	None	1000 genomes	5.99042E-04
31428	21	R/H	23	rs149375775	0.4449	None	gnomAD-4.0.0	1.71026E-04
31428	21	R/S	23	None	0.4449	None	gnomAD-2.1.1	2.5E-05
31428	21	R/S	23	None	0.4449	None	gnomAD-3.1.2	8.54E-05
31428	21	R/S	23	None	0.4449	None	gnomAD-4.0.0	4.27603E-05
31429	22	W/C	24	None	0.1237	None	gnomAD-4.0.0	1.59132E-06
31429	22	W/R	24	None	0.1237	TMD	Literature	None
31429	22	W/R	24	None	0.1237	None	gnomAD-4.0.0	1.20032E-06
31430	23	E/G	25	rs1697596654	0.6618	None	gnomAD-4.0.0	1.5913E-06
31430	23	E/K	25	rs868051341	0.6618	None	gnomAD-3.1.2	6.57E-06
31430	23	E/K	25	rs868051341	0.6618	None	gnomAD-4.0.0	3.04484E-06
31431	24	E/G	26	None	0.6711	None	gnomAD-4.0.0	1.5913E-06
31432	25	P/L	27	rs759415579	0.1626	None	gnomAD-2.1.1	3.22E-05
31432	25	P/L	27	rs759415579	0.1626	None	gnomAD-4.0.0	1.43685E-05
31434	27	H/Y	29	rs773946401	0.5411	None	gnomAD-2.1.1	1.21E-05
31434	27	H/Y	29	rs773946401	0.5411	None	gnomAD-3.1.2	6.57E-06
31434	27	H/Y	29	rs773946401	0.5411	None	gnomAD-4.0.0	7.68675E-06
31435	28	D/G	30	rs1271635080	0.2544	None	gnomAD-2.1.1	4.02E-06
31435	28	D/G	30	rs1271635080	0.2544	None	gnomAD-4.0.0	6.84213E-06
31435	28	D/N	30	rs367771286	0.2544	None	gnomAD-2.1.1	6.43E-05
31435	28	D/N	30	rs367771286	0.2544	None	gnomAD-3.1.2	4.6E-05
31435	28	D/N	30	rs367771286	0.2544	None	gnomAD-4.0.0	6.44479E-05
31436	29	G/D	31	rs550306496	0.3634	None	gnomAD-2.1.1	8.04E-06
31436	29	G/D	31	rs550306496	0.3634	None	gnomAD-3.1.2	6.57E-06
31436	29	G/D	31	rs550306496	0.3634	None	1000 genomes	1.99681E-04
31436	29	G/D	31	rs550306496	0.3634	None	gnomAD-4.0.0	6.19642E-06
31437	30	G/V	32	rs1313606225	0.6230	None	gnomAD-2.1.1	3.18E-05
31437	30	G/V	32	rs1313606225	0.6230	None	gnomAD-3.1.2	6.57E-06
31437	30	G/V	32	rs1313606225	0.6230	None	gnomAD-4.0.0	3.7182E-06
31438	31	S/N	33	rs769930510	0.2985	None	gnomAD-2.1.1	8.04E-06
31438	31	S/N	33	rs769930510	0.2985	None	gnomAD-4.0.0	2.05264E-06
31439	32	K/E	34	None	0.9241	None	gnomAD-4.0.0	1.20032E-06
31441	34	I/F	36	None	0.4313	None	gnomAD-4.0.0	1.59124E-06
31441	34	I/M	36	None	0.4313	None	gnomAD-4.0.0	2.05262E-06
31441	34	I/T	36	rs1388468468	0.4313	None	gnomAD-2.1.1	4.02E-06
31441	34	I/T	36	rs1388468468	0.4313	None	gnomAD-4.0.0	8.21044E-06
31441	34	I/V	36	None	0.4313	None	gnomAD-4.0.0	3.18248E-06
31442	35	G/A	37	None	0.1010	None	gnomAD-4.0.0	2.40064E-06
31444	37	W/C	39	rs1697578690	0.2034	None	gnomAD-3.1.2	6.57E-06
31444	37	W/C	39	rs1697578690	0.2034	None	gnomAD-4.0.0	6.57289E-06
31444	37	W/R	39	rs533447102	0.2034	None	gnomAD-2.1.1	5.62E-05
31444	37	W/R	39	rs533447102	0.2034	None	gnomAD-3.1.2	1.97E-05
31444	37	W/R	39	rs533447102	0.2034	None	1000 genomes	1.99681E-04
31444	37	W/R	39	rs533447102	0.2034	None	gnomAD-4.0.0	2.23073E-05
31445	38	V/I	40	rs564410456	0.1112	None	gnomAD-2.1.1	8.03E-06
31445	38	V/I	40	rs564410456	0.1112	None	gnomAD-3.1.2	6.57E-06
31445	38	V/I	40	rs564410456	0.1112	None	1000 genomes	1.99681E-04
31445	38	V/I	40	rs564410456	0.1112	None	gnomAD-4.0.0	3.09824E-06
31445	38	V/L	40	rs564410456	0.1112	None	gnomAD-2.1.1	4.02E-06
31445	38	V/L	40	rs564410456	0.1112	None	gnomAD-4.0.0	6.84202E-07
31446	39	E/A	41	None	0.1240	None	gnomAD-4.0.0	1.5912E-06
31447	40	K/N	42	rs1169915824	0.1809	None	gnomAD-2.1.1	4.02E-06
31447	40	K/N	42	rs1169915824	0.1809	None	gnomAD-4.0.0	1.59119E-06
31448	41	K/N	43	rs1475927387	0.1089	None	gnomAD-4.0.0	1.36839E-06
31449	42	E/K	44	rs374474093	0.1864	None	gnomAD-2.1.1	4.02E-06
31449	42	E/K	44	rs374474093	0.1864	None	gnomAD-4.0.0	6.84196E-07
31449	42	E/Q	44	rs374474093	0.1864	None	gnomAD-2.1.1	4.02E-06
31450	43	R/C	50	rs541040798	0.5660	None	gnomAD-2.1.1	3.24608E-04
31450	43	R/C	50	rs541040798	0.5660	None	gnomAD-3.1.2	9.21E-05
31450	43	R/C	50	rs541040798	0.5660	None	1000 genomes	3.99361E-04
31450	43	R/C	50	rs541040798	0.5660	None	gnomAD-4.0.0	1.59878E-04
31450	43	R/H	50	rs751985617	0.5660	None	gnomAD-2.1.1	4.02E-06
31450	43	R/H	50	rs751985617	0.5660	None	gnomAD-4.0.0	3.421E-06
31452	45	T/K	60	rs1270325139	0.2677	None	gnomAD-2.1.1	4.02E-06
31452	45	T/K	60	rs1270325139	0.2677	None	gnomAD-4.0.0	1.59117E-06
31453	46	I/F	63	rs780232811	1.0897	None	gnomAD-2.1.1	4.02E-06
31453	46	I/F	63	rs780232811	1.0897	None	gnomAD-4.0.0	6.84196E-07
31453	46	I/V	63	rs780232811	1.0897	None	gnomAD-3.1.2	1.31E-05
31453	46	I/V	63	rs780232811	1.0897	None	gnomAD-4.0.0	4.33778E-06
31454	47	L/F	64	rs758766295	0.7493	None	gnomAD-2.1.1	4.02E-06
31454	47	L/F	64	rs758766295	0.7493	None	gnomAD-4.0.0	5.47357E-06
31454	47	L/I	64	rs758766295	0.7493	None	gnomAD-2.1.1	4.02E-06
31454	47	L/I	64	rs758766295	0.7493	None	gnomAD-3.1.2	6.57E-06
31454	47	L/I	64	rs758766295	0.7493	None	gnomAD-4.0.0	2.4788E-06
31455	48	W/G	65	None	0.2085	None	gnomAD-4.0.0	1.20032E-06
31455	48	W/R	65	rs1697563457	0.2085	None	gnomAD-4.0.0	1.20032E-06
31456	49	V/M	66	rs1559156264	0.4323	None	gnomAD-2.1.1	4.02E-06
31456	49	V/M	66	rs1559156264	0.4323	None	gnomAD-3.1.2	6.57E-06
31456	49	V/M	66	rs1559156264	0.4323	None	gnomAD-4.0.0	2.56218E-06
31458	51	E/G	68	rs763832963	0.1834	None	gnomAD-2.1.1	8.03E-06
31458	51	E/G	68	rs763832963	0.1834	None	gnomAD-4.0.0	3.18238E-06
31458	51	E/K	68	rs1697558384	0.1834	None	gnomAD-4.0.0	1.5912E-06
31460	53	K/Q	70	None	0.9864	None	gnomAD-4.0.0	1.36839E-06
31460	53	K/R	70	None	0.9864	None	gnomAD-4.0.0	1.20032E-06
31461	54	V/L	72	rs1206905148	0.6322	None	gnomAD-3.1.2	6.57E-06
31461	54	V/L	72	rs1206905148	0.6322	None	gnomAD-4.0.0	6.57307E-06
31462	55	P/A	75	None	0.2327	None	gnomAD-4.0.0	6.84202E-07
31462	55	P/S	75	rs1311115144	0.2327	None	gnomAD-4.0.0	6.84202E-07
31462	55	P/T	75	rs1311115144	0.2327	None	gnomAD-3.1.2	6.58E-06
31462	55	P/T	75	rs1311115144	0.2327	None	gnomAD-4.0.0	6.5754E-06
31463	56	C/G	77	None	0.1345	None	gnomAD-4.0.0	1.20032E-06
31463	56	C/Y	77	rs760317660	0.1345	None	gnomAD-2.1.1	4.02E-06
31465	58	E/K	88	rs752194452	0.6752	None	gnomAD-2.1.1	1.07E-05
31465	58	E/K	88	rs752194452	0.6752	None	gnomAD-3.1.2	3.94E-05
31465	58	E/K	88	rs752194452	0.6752	None	gnomAD-4.0.0	5.57718E-06
31465	58	E/Q	88	None	0.6752	None	gnomAD-4.0.0	2.05261E-06
31466	59	C/G	89	rs1697549166	0.1215	None	gnomAD-4.0.0	1.59128E-06
31468	61	Y/C	91	None	0.2402	None	gnomAD-4.0.0	4.10523E-06
31471	64	T/I	94	rs759347301	0.4819	None	gnomAD-2.1.1	1.2E-05
31471	64	T/I	94	rs759347301	0.4819	None	gnomAD-4.0.0	1.02632E-05
31472	65	G/S	96	rs1331080177	0.4836	None	gnomAD-2.1.1	8.03E-06
31472	65	G/S	96	rs1331080177	0.4836	None	gnomAD-4.0.0	2.05263E-06
31473	66	L/S	97	None	0.1207	None	gnomAD-4.0.0	1.20032E-06
31474	67	V/A	98	rs1401860835	0.5218	None	gnomAD-2.1.1	4.02E-06
31474	67	V/A	98	rs1401860835	0.5218	None	gnomAD-4.0.0	1.59129E-06
31474	67	V/I	98	rs1410759884	0.5218	None	gnomAD-2.1.1	7.13E-06
31474	67	V/I	98	rs1410759884	0.5218	None	gnomAD-3.1.2	1.31E-05
31474	67	V/I	98	rs1410759884	0.5218	None	gnomAD-4.0.0	3.84307E-06
31475	68	E/Q	99	rs1171182062	0.5002	None	gnomAD-2.1.1	3.19E-05
31475	68	E/Q	99	rs1171182062	0.5002	None	gnomAD-3.1.2	6.57E-06
31475	68	E/Q	99	rs1171182062	0.5002	None	gnomAD-4.0.0	6.57177E-06
31476	69	G/R	100	rs1481659337	0.2576	None	gnomAD-2.1.1	4.02E-06
31476	69	G/R	100	rs1481659337	0.2576	None	gnomAD-4.0.0	1.5913E-06
31480	73	Q/E	105	None	0.1814	None	gnomAD-4.0.0	1.20032E-06
31480	73	Q/H	105	rs1182145400	0.1814	None	gnomAD-2.1.1	4.02E-06
31480	73	Q/H	105	rs1182145400	0.1814	None	gnomAD-4.0.0	1.59132E-06
31481	74	F/L	106	None	0.1234	None	gnomAD-4.0.0	1.16316E-05
31482	75	R/T	107	None	0.1301	None	gnomAD-4.0.0	1.59132E-06
31488	81	A/D	113	None	0.6642	None	gnomAD-4.0.0	1.59141E-06
31489	82	A/S	114	rs773485371	0.5225	None	gnomAD-2.1.1	4.02E-06
31490	83	G/D	115	None	0.1991	None	gnomAD-4.0.0	2.05278E-06
31490	83	G/R	115	None	0.1991	None	gnomAD-4.0.0	1.20032E-06
31491	84	V/F	117	None	0.3311	None	gnomAD-4.0.0	2.40064E-06
31494	87	A/D	120	rs748231785	0.2089	None	gnomAD-2.1.1	4.03E-06
31494	87	A/D	120	rs748231785	0.2089	None	gnomAD-4.0.0	3.18423E-06
31494	87	A/T	120	rs769948504	0.2089	None	gnomAD-2.1.1	8.05E-06
31494	87	A/T	120	rs769948504	0.2089	None	gnomAD-4.0.0	5.4749E-06
31495	88	S/N	121	rs1329167679	0.1147	None	gnomAD-3.1.2	1.31E-05
31495	88	S/N	121	rs1329167679	0.1147	None	gnomAD-4.0.0	2.47939E-06
31496	89	E/K	122	rs769175534	0.4535	None	gnomAD-2.1.1	2.82E-05
31496	89	E/K	122	rs769175534	0.4535	None	gnomAD-3.1.2	6.57E-06
31496	89	E/K	122	rs769175534	0.4535	None	gnomAD-4.0.0	1.30175E-05
31496	89	E/Q	122	None	0.4535	None	gnomAD-4.0.0	6.84448E-07
31497	90	A/T	123	rs1371205000	0.1894	None	gnomAD-2.1.1	4.03E-06
31497	90	A/T	123	rs1371205000	0.1894	None	gnomAD-3.1.2	6.57E-06
31497	90	A/T	123	rs1371205000	0.1894	None	gnomAD-4.0.0	2.56464E-06
31498	91	S/L	124	rs1281357207	0.1178	None	gnomAD-2.1.1	4.03E-06
31498	91	S/L	124	rs1281357207	0.1178	None	gnomAD-4.0.0	1.36918E-06
31499	92	R/I	125	None	0.8855	None	gnomAD-4.0.0	1.20032E-06
31500	93	P/L	126	None	0.3955	None	gnomAD-4.0.0	1.36998E-06
31500	93	P/R	126	rs747518732	0.3955	None	gnomAD-2.1.1	4.03E-06
31500	93	P/R	126	rs747518732	0.3955	None	gnomAD-3.1.2	6.57E-06
31500	93	P/R	126	rs747518732	0.3955	None	gnomAD-4.0.0	1.86097E-06
31500	93	P/S	126	None	0.3955	None	gnomAD-4.0.0	1.20032E-06
31501	94	I/L	127	None	0.3314	None	gnomAD-4.0.0	6.84981E-07
31501	94	I/T	127	rs758756316	0.3314	None	gnomAD-2.1.1	1.21E-05
31501	94	I/T	127	rs758756316	0.3314	None	gnomAD-4.0.0	2.55288E-05
31501	94	I/V	127	rs780578358	0.3314	None	gnomAD-2.1.1	4.03E-06
31501	94	I/V	127	rs780578358	0.3314	None	gnomAD-3.1.2	1.31E-05
31501	94	I/V	127	rs780578358	0.3314	None	gnomAD-4.0.0	7.44366E-06
31502	95	M/T	129	None	0.2747	None	gnomAD-4.0.0	1.20033E-06
31503	96	A/T	130	rs375657115	0.0614	None	gnomAD-2.1.1	5.04E-05
31503	96	A/T	130	rs375657115	0.0614	None	gnomAD-3.1.2	4.6E-05
31503	96	A/T	130	rs375657115	0.0614	None	1000 genomes	1.99681E-04
31503	96	A/T	130	rs375657115	0.0614	None	gnomAD-4.0.0	5.28468E-05
31504	97	Q/P	131	rs777578106	0.3893	None	gnomAD-2.1.1	8.11E-06
31504	97	Q/P	131	rs777578106	0.3893	None	gnomAD-4.0.0	3.208E-06
31505	98	N/T	132	rs755756435	0.6393	None	gnomAD-2.1.1	1.22E-05
31505	98	N/T	132	rs755756435	0.6393	None	gnomAD-4.0.0	3.43351E-06

Position	Domain position	SAV	RS	Q(SASA)	Source	Structural Position	Disease	AlphaMissense (IC)	AlphaMissense (N2AB)	CADD	Condel	DUET	FATHMM	M-CAP	mCSM	MetaLR	MetaSVM	MPC	MutationAssessor	MutationTaster	MutPred	MVP	PolyPhen-2	PrimateAI	PROVEAN	REVEL	Rhapsody	SIFT	Zygosity	Comments	MAF	AFR	AMR	AMS	ASJ	EAS	EUR	FIN	MDE	NFE	SAS	OTH	Site Annotation	Predicted PPI	mCSM-PPI
31409	2	P/Q	None	0.1208	gnomAD-4.0.0	2	None	0.9982	0.9978	35.0	D	None	-0.05	0.1043	-1.935	0.675	0.6692	0.449032639875	3.355	1.0	0.671	0.701802989099	1.0	0.624354243279	-6.33	0.514	0.829	0.001	None	None	2.40065E-06	0	0	0	0	None	0	0	2.40065E-06	2.62502E-06	0	0	None	N	None
31409	2	P/S	rs1464695009	0.1208	gnomAD-2.1.1	2	None	0.9881	0.9846	33.0	D	-2.196	-0.03	0.047841	-2.042	0.6072	0.4066	0.464868906428	2.66	1.0	0.66	0.49530441419	1.0	0.620469808578	-6.27	0.496	0.759	0.009	None	None	1.24E-05	0	0	0	0	None	1.03505E-04	None	1.24E-05	0	0	0	None	N	None
31409	2	P/S	rs1464695009	0.1208	gnomAD-4.0.0	2	None	0.9881	0.9846	33.0	D	-2.196	-0.03	0.047841	-2.042	0.6072	0.4066	0.464868906428	2.66	1.0	0.66	0.49530441419	1.0	0.620469808578	-6.27	0.496	0.759	0.009	None	None	8.07935E-06	0	0	0	0	None	0	0	8.07935E-06	0	7.29778E-05	0	None	N	None
31411	4	A/T	rs745652405	0.2303	gnomAD-2.1.1	4	None	0.1539	0.1419	None	N	-1.436	None	None	-1.373	None	None	None	None	None	None	None	0.98	None	None	0.307	0.746	None	None	None	4.01E-05	0	0	0	2.0674E-04	None	3.41E-05	None	4.01E-05	0	3.97E-05	1.4497E-04	None	N	None
31411	4	A/T	rs745652405	0.2303	gnomAD-3.1.2	4	None	0.1539	0.1419	None	N	-1.436	None	None	-1.373	None	None	None	None	None	None	None	0.98	None	None	0.307	0.746	None	None	None	1.97E-05	0	0	0	3.85208E-04	None	0	0	1.97E-05	0	2.07469E-04	0	None	N	None
31411	4	A/T	rs745652405	0.2303	gnomAD-4.0.0	4	None	0.1539	0.1419	None	N	-1.436	None	None	-1.373	None	None	None	None	None	None	None	0.98	None	None	0.307	0.746	None	None	None	1.68125E-05	0	0	0	1.33935E-04	None	1.56833E-05	0	1.68125E-05	1.10578E-05	3.33104E-05	6.44891E-05	None	N	None
31412	5	P/A	rs757361681	0.1236	gnomAD-2.1.1	5	None	0.785	0.8302	32.0	D	-2.214	-0.64	0.053951	-2.18	0.665	0.4656	0.457628982806	3.01	1.0	0.673	0.570232391912	1.0	0.615017056465	-6.6	0.592	0.812	0.015	None	None	4.07E-06	0	0	0	0	None	0	None	4.07E-06	0	8.98E-06	0	None	N	None
31412	5	P/A	rs757361681	0.1236	gnomAD-4.0.0	5	None	0.785	0.8302	32.0	D	-2.214	-0.64	0.053951	-2.18	0.665	0.4656	0.457628982806	3.01	1.0	0.673	0.570232391912	1.0	0.615017056465	-6.6	0.592	0.812	0.015	None	None	1.37288E-06	0	0	0	0	None	0	0	1.37288E-06	1.80339E-06	0	0	None	N	None
31412	5	P/L	rs1454161350	0.1236	gnomAD-2.1.1	5	None	0.9496	0.969	35.0	D	-0.69	-0.61	0.090057	-0.905	0.7188	0.6767	0.469182032742	4.165	1.0	0.688	0.804517166174	1.0	0.687724173069	-8.2	0.614	0.911	0.002	None	None	3.19E-05	1.14863E-04	0	0	0	None	0	None	3.19E-05	0	0	0	None	N	None
31412	5	P/L	rs1454161350	0.1236	gnomAD-3.1.2	5	None	0.9496	0.969	35.0	D	-0.69	-0.61	0.090057	-0.905	0.7188	0.6767	0.469182032742	4.165	1.0	0.688	0.804517166174	1.0	0.687724173069	-8.2	0.614	0.911	0.002	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
31412	5	P/L	rs1454161350	0.1236	gnomAD-4.0.0	5	None	0.9496	0.969	35.0	D	-0.69	-0.61	0.090057	-0.905	0.7188	0.6767	0.469182032742	4.165	1.0	0.688	0.804517166174	1.0	0.687724173069	-8.2	0.614	0.911	0.002	None	None	2.57798E-06	3.39847E-05	0	0	0	None	0	0	2.57798E-06	0	0	0	None	N	None
31412	5	P/S	rs757361681	0.1236	gnomAD-2.1.1	5	None	0.9772	0.9846	33.0	D	-2.789	-0.67	0.062019	-2.673	0.6743	0.5022	0.466644225527	3.615	1.0	0.633	0.578554888259	1.0	0.621927022934	-6.6	0.606	0.867	0.043	None	None	4.07E-06	0	0	0	0	None	0	None	4.07E-06	0	8.98E-06	0	None	N	None
31412	5	P/S	rs757361681	0.1236	gnomAD-4.0.0	5	None	0.9772	0.9846	33.0	D	-2.789	-0.67	0.062019	-2.673	0.6743	0.5022	0.466644225527	3.615	1.0	0.633	0.578554888259	1.0	0.621927022934	-6.6	0.606	0.867	0.043	None	None	6.86442E-07	0	0	0	0	None	0	0	6.86442E-07	9.01694E-07	0	0	None	N	None
31413	6	T/A	rs1361033922	0.3578	gnomAD-2.1.1	6	None	0.0748	0.0816	25.0	N	-0.794	0.35	0.008573	-0.951	0.1308	-0.8867	0.193276071692	0.665	0.999456	0.5	0.233785782151	0.64	0.432069420815	-3.12	0.163	0.494	0.245	None	None	4.06E-06	0	0	0	0	None	3.32E-05	None	4.06E-06	0	0	0	None	N	None
31413	6	T/A	rs1361033922	0.3578	gnomAD-4.0.0	6	None	0.0748	0.0816	25.0	N	-0.794	0.35	0.008573	-0.951	0.1308	-0.8867	0.193276071692	0.665	0.999456	0.5	0.233785782151	0.64	0.432069420815	-3.12	0.163	0.494	0.245	None	None	2.7443E-06	0	0	0	0	None	0	0	2.7443E-06	0	4.65864E-05	0	None	N	None
31414	7	R/G	rs369418580	0.3067	gnomAD-2.1.1	7	None	0.6728	0.6663	None	N	-0.334	None	None	-0.88	None	None	None	None	None	None	None	1.0	None	None	0.365	0.665	None	None	None	1.8E-05	0	0	0	0	None	0	None	1.8E-05	8.05E-05	2.36E-05	0	None	N	None
31414	7	R/G	rs369418580	0.3067	gnomAD-3.1.2	7	None	0.6728	0.6663	None	N	-0.334	None	None	-0.88	None	None	None	None	None	None	None	1.0	None	None	0.365	0.665	None	None	None	1.97E-05	0	0	0	0	None	0	0	1.97E-05	4.41E-05	0	0	None	N	None
31414	7	R/G	rs369418580	0.3067	gnomAD-4.0.0	7	None	0.6728	0.6663	None	N	-0.334	None	None	-0.88	None	None	None	None	None	None	None	1.0	None	None	0.365	0.665	None	None	None	1.80127E-05	0	0	0	0	None	6.25763E-05	0	1.80127E-05	2.12312E-05	0	0	None	N	None
31415	8	P/L	rs756168192	0.1342	gnomAD-2.1.1	9	None	0.7598	0.7502	35.0	N	-0.816	0.97	0.040057	-0.778	0.2963	-0.537	0.469182032742	1.725	1.0	0.445	0.503868428259	1.0	0.700865089893	-8.2	0.406	0.885	0.009	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.92E-06	0	None	N	None
31415	8	P/L	rs756168192	0.1342	gnomAD-4.0.0	9	None	0.7598	0.7502	35.0	N	-0.816	0.97	0.040057	-0.778	0.2963	-0.537	0.469182032742	1.725	1.0	0.445	0.503868428259	1.0	0.700865089893	-8.2	0.406	0.885	0.009	None	None	1.59585E-06	0	0	0	0	None	0	0	1.59585E-06	2.86847E-06	0	0	None	N	None
31417	10	V/A	rs878947167	0.2409	gnomAD-2.1.1	12	None	0.4484	0.4535	None	N	-1.335	None	None	-1.823	None	None	None	None	None	None	None	0.834	None	None	0.282	0.585	None	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	0	1.66279E-04	None	N	None
31417	10	V/A	rs878947167	0.2409	gnomAD-4.0.0	12	None	0.4484	0.4535	None	N	-1.335	None	None	-1.823	None	None	None	None	None	None	None	0.834	None	None	0.282	0.585	None	None	None	5.47692E-06	0	0	0	0	None	0	0	5.47692E-06	7.19996E-06	0	0	None	N	None
31417	10	V/I	rs1188866872	0.2409	gnomAD-3.1.2	12	None	0.0764	0.0806	23.5	N	None	0.26	0.006567	-0.481	0.1421	-0.9394	0.0714209987842	0.725	0.999994	0.502	0.413761986042	0.016	0.454587757587	-0.67	0.106	0.288	0.242	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
31417	10	V/I	rs1188866872	0.2409	gnomAD-4.0.0	12	None	0.0764	0.0806	23.5	N	None	0.26	0.006567	-0.481	0.1421	-0.9394	0.0714209987842	0.725	0.999994	0.502	0.413761986042	0.016	0.454587757587	-0.67	0.106	0.288	0.242	None	None	6.57333E-06	0	0	0	0	None	0	0	6.57333E-06	1.47029E-05	0	0	None	N	None
31420	13	V/M	rs1697609809	0.2480	gnomAD-4.0.0	15	None	0.2496	0.2739	26.3	N	None	0.21	0.014253	-0.556	0.3849	-0.1599	0.358552384932	2.21	0.999996	0.603	0.627153701111	0.83	0.570867776871	-2.3	0.315	0.7	0.004	None	None	6.84396E-07	0	0	0	0	None	0	0	6.84396E-07	8.99719E-07	0	0	None	N	None
31422	15	A/P	rs755395347	0.1359	gnomAD-2.1.1	17	None	0.4017	0.3862	26.8	N	-0.717	0.42	0.015716	-0.695	0.2285	-0.6933	0.48501629426	1.225	0.999976	0.613	0.435590266561	0.991	0.661238193512	-3.58	0.293	0.673	0.065	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	N	None
31422	15	A/P	rs755395347	0.1359	gnomAD-4.0.0	17	None	0.4017	0.3862	26.8	N	-0.717	0.42	0.015716	-0.695	0.2285	-0.6933	0.48501629426	1.225	0.999976	0.613	0.435590266561	0.991	0.661238193512	-3.58	0.293	0.673	0.065	None	None	1.59183E-06	0	0	0	0	None	0	0	1.59183E-06	2.85943E-06	0	0	None	N	None
31422	15	A/V	None	0.1359	gnomAD-4.0.0	17	None	0.2387	0.2186	35.0	N	None	0.3	0.011973	-0.695	0.3289	-0.4159	0.360025565734	2.325	0.999978	0.426	0.458101713262	0.969	0.624256432056	-2.98	0.255	0.617	0.104	None	None	1.59161E-06	0	0	0	0	None	0	0	1.59161E-06	0	1.43287E-05	0	None	N	None
31423	16	N/H	rs751814511	0.5761	gnomAD-2.1.1	18	None	0.116	0.132	27.8	N	-0.823	0.29	0.014951	-0.933	0.288	-0.5171	0.299086279298	1.675	0.999995	0.515	0.247872288689	0.859	0.422769516706	-3.73	0.282	0.491	0.01	None	None	4.02E-06	0	0	0	5.57E-05	None	0	None	4.02E-06	0	0	0	None	I	None
31423	16	N/H	rs751814511	0.5761	gnomAD-4.0.0	18	None	0.116	0.132	27.8	N	-0.823	0.29	0.014951	-0.933	0.288	-0.5171	0.299086279298	1.675	0.999995	0.515	0.247872288689	0.859	0.422769516706	-3.73	0.282	0.491	0.01	None	None	1.59153E-06	0	0	0	2.77346E-05	None	0	0	1.59153E-06	0	0	0	None	I	None
31423	16	N/K	rs1387191410	0.5761	gnomAD-2.1.1	18	None	0.3702	0.4609	23.5	N	0.406	0.32	0.015979	0.008	0.1838	-0.8477	0.119457425379	1.385	0.999367	0.578	0.16115917748	0.22	0.480606198311	-4.4	0.133	0.455	0.013	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	I	None
31423	16	N/K	rs1387191410	0.5761	gnomAD-4.0.0	18	None	0.3702	0.4609	23.5	N	0.406	0.32	0.015979	0.008	0.1838	-0.8477	0.119457425379	1.385	0.999367	0.578	0.16115917748	0.22	0.480606198311	-4.4	0.133	0.455	0.013	None	None	1.59148E-06	0	0	0	0	None	0	0	1.59148E-06	2.85884E-06	0	0	None	I	None
31424	17	A/P	None	0.1413	gnomAD-4.0.0	19	None	0.9722	0.9822	28.8	N	None	0.37	0.015233	-0.594	0.2407	-0.6875	0.325679877116	2.55	0.999932	0.616	0.405422107966	0.497	0.561585187912	-3.4	0.269	0.757	0.013	None	None	1.59158E-06	0	0	0	0	None	0	0	1.59158E-06	0	1.43303E-05	0	None	N	None
31424	17	A/V	rs1178719189	0.1413	gnomAD-4.0.0	19	None	0.1221	0.1539	29.8	N	None	0.4	0.030138	-0.594	0.1513	-0.9636	0.0874796342918	1.23	0.999947	0.485	0.362160248664	0.009	0.525069773197	-2.7	0.17	0.345	0.011	None	None	1.20033E-06	0	0	0	0	None	0	0	1.20033E-06	1.31251E-06	0	0	None	N	None
31425	18	M/I	None	0.0799	gnomAD-4.0.0	20	None	0.4662	0.4746	25.8	N	None	0.57	0.007838	-0.429	0.1075	-1.0211	0.0935167950284	-0.04	0.999455	0.478	0.434606191737	0.001	0.541902303696	-2.07	0.135	0.251	0.427	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
31425	18	M/K	rs764947983	0.0799	gnomAD-2.1.1	20	None	0.9851	0.9865	29.1	N	-1.066	0.37	0.030507	-1.186	0.3003	-0.2601	0.309992911721	2.63	1.0	0.686	0.695986974221	0.784	0.614432096481	-4.62	0.502	0.725	0.022	None	None	3.18E-05	0	0	0	0	None	0	None	3.18E-05	0	0	9.19118E-04	None	N	None
31425	18	M/K	rs764947983	0.0799	gnomAD-3.1.2	20	None	0.9851	0.9865	29.1	N	-1.066	0.37	0.030507	-1.186	0.3003	-0.2601	0.309992911721	2.63	1.0	0.686	0.695986974221	0.784	0.614432096481	-4.62	0.502	0.725	0.022	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
31425	18	M/K	rs764947983	0.0799	gnomAD-4.0.0	20	None	0.9851	0.9865	29.1	N	-1.066	0.37	0.030507	-1.186	0.3003	-0.2601	0.309992911721	2.63	1.0	0.686	0.695986974221	0.784	0.614432096481	-4.62	0.502	0.725	0.022	None	None	2.56218E-06	0	0	0	0	None	0	0	2.56218E-06	4.78652E-06	0	0	None	N	None
31425	18	M/T	rs764947983	0.0799	gnomAD-2.1.1	20	None	0.8825	0.884	27.4	N	-1.723	0.39	0.034333	-1.792	0.2261	-0.535	0.190863816393	2.63	0.999999	0.612	0.691146523942	0.642	0.654995858669	-4.25	0.445	0.7	0.103	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	N	None
31425	18	M/T	rs764947983	0.0799	gnomAD-4.0.0	20	None	0.8825	0.884	27.4	N	-1.723	0.39	0.034333	-1.792	0.2261	-0.535	0.190863816393	2.63	0.999999	0.612	0.691146523942	0.642	0.654995858669	-4.25	0.445	0.7	0.103	None	None	1.59138E-06	0	0	0	0	None	0	0	1.59138E-06	2.85865E-06	0	0	None	N	None
31426	19	S/F	rs369284856	0.1202	gnomAD-2.1.1	21	None	0.2039	0.2615	None	N	-0.292	None	None	-0.316	None	None	None	None	None	None	None	0.003	None	None	0.304	0.509	None	None	None	8.05E-06	1.29216E-04	0	0	0	None	0	None	8.05E-06	0	0	0	None	N	None
31426	19	S/F	rs369284856	0.1202	gnomAD-3.1.2	21	None	0.2039	0.2615	None	N	-0.292	None	None	-0.316	None	None	None	None	None	None	None	0.003	None	None	0.304	0.509	None	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
31426	19	S/F	rs369284856	0.1202	gnomAD-4.0.0	21	None	0.2039	0.2615	None	N	-0.292	None	None	-0.316	None	None	None	None	None	None	None	0.003	None	None	0.304	0.509	None	None	None	2.56221E-06	3.38226E-05	0	0	0	None	0	0	2.56221E-06	0	0	0	None	N	None
31427	20	I/L	rs776226409	0.0772	gnomAD-2.1.1	22	None	0.1424	0.1496	29.8	N	-0.713	1.14	0.022953	-1.133	0.1148	-0.8136	0.456683706047	-0.93	0.999991	0.5	0.31501682445	0.993	0.665697336197	-1.43	0.291	0.382	0.206	None	None	8.04E-06	0	0	0	0	None	0	None	8.04E-06	0	1.78E-05	0	None	N	None
31427	20	I/L	rs776226409	0.0772	gnomAD-4.0.0	22	None	0.1424	0.1496	29.8	N	-0.713	1.14	0.022953	-1.133	0.1148	-0.8136	0.456683706047	-0.93	0.999991	0.5	0.31501682445	0.993	0.665697336197	-1.43	0.291	0.382	0.206	None	None	4.10533E-06	0	0	0	0	None	0	0	4.10533E-06	5.39699E-06	0	0	None	N	None
31427	20	I/V	None	0.0772	gnomAD-4.0.0	22	None	0.1061	0.1082	28.0	N	None	0.78	0.007869	-1.69	0.1705	-0.6909	0.422359933901	0.225	0.999978	0.544	0.470890129789	0.993	0.582080066204	-0.8	0.246	0.343	0.165	None	None	6.84222E-07	0	0	0	0	None	0	0	6.84222E-07	0	1.15934E-05	0	None	N	None
31428	21	R/C	rs190282707	0.4449	gnomAD-2.1.1	23	None	0.1257	0.1373	35.0	N	-1.298	0.31	0.030899	-0.944	0.3032	-0.4968	0.521965020797	0.66	1.0	0.613	0.717641377234	1.0	0.661938071251	-6.12	0.384	0.772	0.008	None	None	2.5E-05	0	2.83E-05	0	2.04939E-04	None	0	None	2.5E-05	0	7.82E-06	1.40489E-04	None	N	None
31428	21	R/C	rs190282707	0.4449	gnomAD-3.1.2	23	None	0.1257	0.1373	35.0	N	-1.298	0.31	0.030899	-0.944	0.3032	-0.4968	0.521965020797	0.66	1.0	0.613	0.717641377234	1.0	0.661938071251	-6.12	0.384	0.772	0.008	None	None	3.94E-05	4.83E-05	0	0	5.78258E-04	None	0	0	3.94E-05	0	2.06868E-04	0	None	N	None
31428	21	R/C	rs190282707	0.4449	gnomAD-4.0.0	23	None	0.1257	0.1373	35.0	N	-1.298	0.31	0.030899	-0.944	0.3032	-0.4968	0.521965020797	0.66	1.0	0.613	0.717641377234	1.0	0.661938071251	-6.12	0.384	0.772	0.008	None	None	1.05344E-05	3.99936E-05	0	0	2.45164E-04	None	0	0	1.05344E-05	8.47646E-07	1.09791E-05	1.60067E-05	None	N	None
31428	21	R/G	rs190282707	0.4449	gnomAD-2.1.1	23	None	0.2802	0.3442	None	N	-1.919	None	None	-1.349	None	None	None	None	None	None	None	0.996	None	None	0.385	0.617	None	None	None	1.07135E-04	1.23987E-03	0	0	0	None	0	None	1.07135E-04	0	0	0	None	N	None
31428	21	R/G	rs190282707	0.4449	gnomAD-3.1.2	23	None	0.2802	0.3442	None	N	-1.919	None	None	-1.349	None	None	None	None	None	None	None	0.996	None	None	0.385	0.617	None	None	None	2.76051E-04	9.89764E-04	6.55E-05	0	0	None	0	0	2.76051E-04	0	0	0	None	N	None
31428	21	R/G	rs190282707	0.4449	gnomAD-4.0.0	23	None	0.2802	0.3442	None	N	-1.919	None	None	-1.349	None	None	None	None	None	None	None	0.996	None	None	0.385	0.617	None	None	None	4.52359E-05	9.06522E-04	3.33267E-05	0	0	None	0	0	4.52359E-05	0	0	4.802E-05	None	N	None
31428	21	R/H	rs149375775	0.4449	gnomAD-2.1.1	23	None	0.0882	0.1011	None	N	-1.782	None	None	-1.496	None	None	None	None	None	None	None	1.0	None	None	0.369	0.55	None	None	None	2.78548E-04	2.52108E-03	2.2627E-04	0	5.13E-05	None	0	None	2.78548E-04	0	3.91E-05	4.21585E-04	None	N	None
31428	21	R/H	rs149375775	0.4449	gnomAD-3.1.2	23	None	0.0882	0.1011	None	N	-1.782	None	None	-1.496	None	None	None	None	None	None	None	1.0	None	None	0.369	0.55	None	None	None	8.74011E-04	3.01612E-03	1.30959E-04	0	0	None	0	0	8.74011E-04	4.41E-05	0	1.43541E-03	None	N	None
31428	21	R/H	rs149375775	0.4449	1000 genomes	23	None	0.0882	0.1011	None	N	-1.782	None	None	-1.496	None	None	None	None	None	None	None	1.0	None	None	0.369	0.55	None	None	None	5.99042E-04	2.3E-03	0	None	0	0	None	None	5.99042E-04	None	0	None	None	N	None
31428	21	R/H	rs149375775	0.4449	gnomAD-4.0.0	23	None	0.0882	0.1011	None	N	-1.782	None	None	-1.496	None	None	None	None	None	None	None	1.0	None	None	0.369	0.55	None	None	None	1.71026E-04	2.93216E-03	1.83291E-04	0	2.22866E-05	None	0	1.65071E-04	1.71026E-04	2.37341E-05	1.09794E-05	2.24086E-04	None	N	None
31428	21	R/S	None	0.4449	gnomAD-2.1.1	23	None	0.3396	0.3953	None	N	-1.715	None	None	-1.328	None	None	None	None	None	None	None	0.992	None	None	0.401	0.573	None	None	None	2.5E-05	4.13E-05	0	0	0	None	0	None	2.5E-05	0	4.69E-05	0	None	N	None
31428	21	R/S	None	0.4449	gnomAD-3.1.2	23	None	0.3396	0.3953	None	N	-1.715	None	None	-1.328	None	None	None	None	None	None	None	0.992	None	None	0.401	0.573	None	None	None	8.54E-05	4.83E-05	0	0	0	None	0	0	8.54E-05	1.47011E-04	0	4.78469E-04	None	N	None
31428	21	R/S	None	0.4449	gnomAD-4.0.0	23	None	0.3396	0.3953	None	N	-1.715	None	None	-1.328	None	None	None	None	None	None	None	0.992	None	None	0.401	0.573	None	None	None	4.27603E-05	5.34117E-05	0	0	0	None	0	0	4.27603E-05	5.25537E-05	0	4.80369E-05	None	N	None
31429	22	W/C	None	0.1237	gnomAD-4.0.0	24	None	0.9989	0.9991	35.0	D	None	-2.1	0.302888	-2.006	0.8919	1.0041	0.580146131267	4.185	1.0	0.862	0.887746986894	1.0	0.754304885864	-10.6	0.772	0.844	0.001	None	None	1.59132E-06	0	0	0	0	None	0	0	1.59132E-06	2.85858E-06	0	0	None	N	None
31429	22	W/R	None	0.1237	http://www.ncbi.nlm.nih.gov/pubmed/27796757;	24	TMD;	0.9997	0.9997	35.0	D	-1.936	-2.1	0.290998	-2.074	0.8823	1.0361	0.615612516959	4.185	1.0	0.888	0.906553756881	1.0	0.783920764923	-11.4	0.861	0.913	0.001	comp het with R21209*	Genetic analysis of genes in 10 TMD families; co-segregation in 2-generation family (recessive inheritance, n = 3, 1 affected (total 5; disease state only where compound heterozygous for both W31429R and R21209)); variant prioritisation; comp het with R21209	None	None	None	None	None	None	None	None	None	None	None	None	None	N	None
31429	22	W/R	None	0.1237	gnomAD-4.0.0	24	None	0.9997	0.9997	35.0	D	-1.936	-2.1	0.290998	-2.074	0.8823	1.0361	0.615612516959	4.185	1.0	0.888	0.906553756881	1.0	0.783920764923	-11.4	0.861	0.913	0.001	None	None	1.20032E-06	0	1.01626E-03	0	0	None	0	0	1.20032E-06	0	0	0	None	N	None
31430	23	E/G	rs1697596654	0.6618	gnomAD-4.0.0	25	None	0.2864	0.3233	35.0	N	None	0.27	0.038774	-0.737	0.3458	-0.3357	0.430256033579	1.15	1.0	0.418	0.470566500458	0.978	0.443280696869	-4.77	0.432	0.656	0.021	None	None	1.5913E-06	0	0	0	0	None	0	0	1.5913E-06	2.8585E-06	0	0	None	I	None
31430	23	E/K	rs868051341	0.6618	gnomAD-3.1.2	25	None	0.3673	0.444	34.0	N	None	0.42	0.0283	-0.075	0.2237	-0.6977	0.398684265096	-0.065	1.0	0.631	0.303453137403	0.978	0.572393298149	-2.84	0.403	0.554	0.15	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
31430	23	E/K	rs868051341	0.6618	gnomAD-4.0.0	25	None	0.3673	0.444	34.0	N	None	0.42	0.0283	-0.075	0.2237	-0.6977	0.398684265096	-0.065	1.0	0.631	0.303453137403	0.978	0.572393298149	-2.84	0.403	0.554	0.15	None	None	3.04484E-06	0	0	0	0	None	0	0	3.04484E-06	3.61477E-06	0	0	None	I	None
31431	24	E/G	None	0.6711	gnomAD-4.0.0	26	None	0.2279	0.2671	35.0	N	None	0.39	0.039252	-0.52	0.2616	-0.5743	0.384797634197	1.485	0.999978	0.433	0.414798848334	0.986	0.442910075188	-4.3	0.311	0.549	0.065	None	None	1.5913E-06	0	2.28634E-05	0	0	None	0	0	1.5913E-06	0	0	0	None	N	None
31432	25	P/L	rs759415579	0.1626	gnomAD-2.1.1	27	None	0.9763	0.9809	35.0	D	-0.488	-0.83	0.079363	-0.638	0.7393	0.6827	0.469182032742	3.525	1.0	0.797	0.904311493753	1.0	0.685132920742	-8.3	0.62	0.898	0.002	None	None	3.22E-05	0	0	0	0	None	2.61472E-04	None	3.22E-05	0	0	0	None	N	None
31432	25	P/L	rs759415579	0.1626	gnomAD-4.0.0	27	None	0.9763	0.9809	35.0	D	-0.488	-0.83	0.079363	-0.638	0.7393	0.6827	0.469182032742	3.525	1.0	0.797	0.904311493753	1.0	0.685132920742	-8.3	0.62	0.898	0.002	None	None	1.43685E-05	0	0	0	0	None	0	0	1.43685E-05	0	2.31879E-04	1.65662E-05	None	N	None
31434	27	H/Y	rs773946401	0.5411	gnomAD-2.1.1	29	None	0.1573	0.1602	34.0	N	0.985	0.62	0.063093	1.006	0.1276	-0.7283	0.379884591137	0.46	0.999911	0.355	0.228597637076	0.985	0.630084335804	-4.53	0.309	0.303	0.1	None	None	1.21E-05	0	0	0	0	None	9.81E-05	None	1.21E-05	0	0	0	None	I	None
31434	27	H/Y	rs773946401	0.5411	gnomAD-3.1.2	29	None	0.1573	0.1602	34.0	N	0.985	0.62	0.063093	1.006	0.1276	-0.7283	0.379884591137	0.46	0.999911	0.355	0.228597637076	0.985	0.630084335804	-4.53	0.309	0.303	0.1	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	0	2.07297E-04	0	None	I	None
31434	27	H/Y	rs773946401	0.5411	gnomAD-4.0.0	29	None	0.1573	0.1602	34.0	N	0.985	0.62	0.063093	1.006	0.1276	-0.7283	0.379884591137	0.46	0.999911	0.355	0.228597637076	0.985	0.630084335804	-4.53	0.309	0.303	0.1	None	None	7.68675E-06	0	0	0	0	None	0	0	7.68675E-06	0	8.04096E-05	0	None	I	None
31435	28	D/G	rs1271635080	0.2544	gnomAD-2.1.1	30	None	0.7899	0.8198	35.0	N	-0.746	0.27	0.025563	-0.584	0.4957	0.1765	0.528847580626	4.035	1.0	0.479	0.435915822735	1.0	0.625194847584	-5.6	0.53	0.687	0.046	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	I	None
31435	28	D/G	rs1271635080	0.2544	gnomAD-4.0.0	30	None	0.7899	0.8198	35.0	N	-0.746	0.27	0.025563	-0.584	0.4957	0.1765	0.528847580626	4.035	1.0	0.479	0.435915822735	1.0	0.625194847584	-5.6	0.53	0.687	0.046	None	None	6.84213E-06	0	0	0	0	None	0	0	6.84213E-06	8.99489E-06	0	0	None	I	None
31435	28	D/N	rs367771286	0.2544	gnomAD-2.1.1	30	None	0.1685	0.1884	None	N	-0.538	None	None	-0.422	None	None	None	None	None	None	None	1.0	None	None	0.393	0.69	None	None	None	6.43E-05	1.23977E-04	2.83E-05	0	0	None	6.54E-05	None	6.43E-05	0	9.38E-05	0	None	I	None
31435	28	D/N	rs367771286	0.2544	gnomAD-3.1.2	30	None	0.1685	0.1884	None	N	-0.538	None	None	-0.422	None	None	None	None	None	None	None	1.0	None	None	0.393	0.69	None	None	None	4.6E-05	9.65E-05	6.54E-05	0	0	None	9.43E-05	0	4.6E-05	1.47E-05	0	0	None	I	None
31435	28	D/N	rs367771286	0.2544	gnomAD-4.0.0	30	None	0.1685	0.1884	None	N	-0.538	None	None	-0.422	None	None	None	None	None	None	None	1.0	None	None	0.393	0.69	None	None	None	6.44479E-05	8.00961E-05	3.33322E-05	0	2.22806E-05	None	4.68677E-05	0	6.44479E-05	7.20481E-05	4.39126E-05	4.80354E-05	None	I	None
31436	29	G/D	rs550306496	0.3634	gnomAD-2.1.1	31	None	0.9946	0.9952	33.0	N	-0.917	0.45	0.053919	-0.937	0.4937	0.1332	0.527275360279	4.125	1.0	0.79	0.422524665647	1.0	0.719220221043	-5.83	0.638	0.831	None	None	None	8.04E-06	0	0	0	0	None	0	None	8.04E-06	0	1.78E-05	0	None	I	None
31436	29	G/D	rs550306496	0.3634	gnomAD-3.1.2	31	None	0.9946	0.9952	33.0	N	-0.917	0.45	0.053919	-0.937	0.4937	0.1332	0.527275360279	4.125	1.0	0.79	0.422524665647	1.0	0.719220221043	-5.83	0.638	0.831	None	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
31436	29	G/D	rs550306496	0.3634	1000 genomes	31	None	0.9946	0.9952	33.0	N	-0.917	0.45	0.053919	-0.937	0.4937	0.1332	0.527275360279	4.125	1.0	0.79	0.422524665647	1.0	0.719220221043	-5.83	0.638	0.831	None	None	None	1.99681E-04	0	0	None	0	1E-03	None	None	1.99681E-04	None	0	None	None	I	None
31436	29	G/D	rs550306496	0.3634	gnomAD-4.0.0	31	None	0.9946	0.9952	33.0	N	-0.917	0.45	0.053919	-0.937	0.4937	0.1332	0.527275360279	4.125	1.0	0.79	0.422524665647	1.0	0.719220221043	-5.83	0.638	0.831	None	None	None	6.19642E-06	0	0	0	0	None	0	0	6.19642E-06	8.47623E-06	0	0	None	I	None
31437	30	G/V	rs1313606225	0.6230	gnomAD-2.1.1	32	None	0.969	0.9703	33.0	D	0.001	-0.16	0.139404	-0.265	0.637	0.5253	0.518063289252	4.075	1.0	0.533	0.863765479448	1.0	0.585198163986	-7.5	0.517	0.795	None	None	None	3.18E-05	0	0	0	0	None	0	None	3.18E-05	0	6.48E-05	0	None	I	None
31437	30	G/V	rs1313606225	0.6230	gnomAD-3.1.2	32	None	0.969	0.9703	33.0	D	0.001	-0.16	0.139404	-0.265	0.637	0.5253	0.518063289252	4.075	1.0	0.533	0.863765479448	1.0	0.585198163986	-7.5	0.517	0.795	None	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
31437	30	G/V	rs1313606225	0.6230	gnomAD-4.0.0	32	None	0.969	0.9703	33.0	D	0.001	-0.16	0.139404	-0.265	0.637	0.5253	0.518063289252	4.075	1.0	0.533	0.863765479448	1.0	0.585198163986	-7.5	0.517	0.795	None	None	None	3.7182E-06	0	0	0	0	None	0	0	3.7182E-06	5.08578E-06	0	0	None	I	None
31438	31	S/N	rs769930510	0.2985	gnomAD-2.1.1	33	None	0.5743	0.4913	32.0	N	-0.418	0.3	0.035145	-0.539	0.4881	0.0155	0.448649923726	2.745	1.0	0.417	0.297718772494	0.999	0.603097319603	-2.5	0.367	0.73	0.021	None	None	8.04E-06	0	5.79E-05	0	0	None	0	None	8.04E-06	0	0	0	None	I	None
31438	31	S/N	rs769930510	0.2985	gnomAD-4.0.0	33	None	0.5743	0.4913	32.0	N	-0.418	0.3	0.035145	-0.539	0.4881	0.0155	0.448649923726	2.745	1.0	0.417	0.297718772494	0.999	0.603097319603	-2.5	0.367	0.73	0.021	None	None	2.05264E-06	0	4.47227E-05	0	0	None	0	0	2.05264E-06	8.99493E-07	0	0	None	I	None
31439	32	K/E	None	0.9241	gnomAD-4.0.0	34	None	0.1491	0.1723	35.0	N	None	0.53	0.014209	-0.106	0.1629	-0.7655	0.393197928144	0.335	0.999976	0.542	0.253726318573	0.956	0.605602383614	-2.8	0.29	0.561	0.4	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
31441	34	I/F	None	0.4313	gnomAD-4.0.0	36	None	0.1249	0.1228	24.2	N	None	0.41	0.012124	-0.709	0.1799	-0.8603	0.165782956419	1.76	0.957073	0.471	0.45349784317	0.055	0.286693871021	-2.48	0.133	0.36	0.208	None	None	1.59124E-06	0	0	0	0	None	0	0	1.59124E-06	2.85842E-06	0	0	None	I	None
31441	34	I/M	None	0.4313	gnomAD-4.0.0	36	None	0.0682	0.0699	25.4	N	None	0.4	0.006504	-0.445	0.1188	-0.9538	0.162580693133	1.65	0.98409	0.416	0.432154444652	0.171	0.273881196976	-1.43	0.043	0.375	0.033	None	None	2.05262E-06	0	0	0	0	None	0	0	2.05262E-06	0	3.47802E-05	0	None	I	None
31441	34	I/T	rs1388468468	0.4313	gnomAD-2.1.1	36	None	0.0558	0.0535	25.5	N	-1.358	0.63	0.005246	-1.065	0.0468	-1.0278	0.105969166871	-1.025	0.99599	0.419	0.247872288689	None	0.316127866507	-0.61	0.104	0.156	0.625	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	I	None
31441	34	I/T	rs1388468468	0.4313	gnomAD-4.0.0	36	None	0.0558	0.0535	25.5	N	-1.358	0.63	0.005246	-1.065	0.0468	-1.0278	0.105969166871	-1.025	0.99599	0.419	0.247872288689	None	0.316127866507	-0.61	0.104	0.156	0.625	None	None	8.21044E-06	0	0	0	2.51915E-05	None	0	0	8.21044E-06	8.9948E-06	1.15934E-05	0	None	I	None
31441	34	I/V	None	0.4313	gnomAD-4.0.0	36	None	0.0593	0.0569	23.5	N	None	0.5	0.003848	-0.659	0.109	-0.9865	0.0704899027279	1.21	0.999791	0.367	0.291694819147	None	0.257578074932	0.18	0.038	0.085	0.663	None	None	3.18248E-06	0	0	0	0	None	0	0	3.18248E-06	5.71683E-06	0	0	None	I	None
31442	35	G/A	None	0.1010	gnomAD-4.0.0	37	None	0.6019	0.6327	32.0	N	None	0.15	0.036235	-0.31	0.4986	0.0576	0.480971576196	2.85	1.0	0.65	0.463501289208	1.0	0.688086390495	-4.97	0.498	0.592	0.053	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	1.3125E-06	0	3.66327E-05	None	N	None
31444	37	W/C	rs1697578690	0.2034	gnomAD-3.1.2	39	None	0.7723	0.7168	35.0	N	None	0.44	0.01912	-1.644	0.2869	-0.5663	0.580146131267	1.355	1.0	0.576	0.507928266286	1.0	0.758888602257	-9.45	0.388	0.797	0.033	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
31444	37	W/C	rs1697578690	0.2034	gnomAD-4.0.0	39	None	0.7723	0.7168	35.0	N	None	0.44	0.01912	-1.644	0.2869	-0.5663	0.580146131267	1.355	1.0	0.576	0.507928266286	1.0	0.758888602257	-9.45	0.388	0.797	0.033	None	None	6.57289E-06	2.41406E-05	0	0	0	None	0	0	6.57289E-06	0	0	0	None	N	None
31444	37	W/R	rs533447102	0.2034	gnomAD-2.1.1	39	None	0.9399	0.919	35.0	N	-1.794	0.61	0.066339	-1.671	0.2324	-0.6559	0.615612516959	0.855	1.0	0.548	0.630156806279	1.0	0.789732933044	-10.1	0.5	0.839	0.063	None	None	5.62E-05	6.46E-05	0	0	0	None	3.92131E-04	None	5.62E-05	0	0	1.65508E-04	None	N	None
31444	37	W/R	rs533447102	0.2034	gnomAD-3.1.2	39	None	0.9399	0.919	35.0	N	-1.794	0.61	0.066339	-1.671	0.2324	-0.6559	0.615612516959	0.855	1.0	0.548	0.630156806279	1.0	0.789732933044	-10.1	0.5	0.839	0.063	None	None	1.97E-05	2.41E-05	0	0	0	None	0	0	1.97E-05	0	4.14422E-04	0	None	N	None
31444	37	W/R	rs533447102	0.2034	1000 genomes	39	None	0.9399	0.919	35.0	N	-1.794	0.61	0.066339	-1.671	0.2324	-0.6559	0.615612516959	0.855	1.0	0.548	0.630156806279	1.0	0.789732933044	-10.1	0.5	0.839	0.063	None	None	1.99681E-04	0	0	None	0	0	None	None	1.99681E-04	None	1E-03	None	None	N	None
31444	37	W/R	rs533447102	0.2034	gnomAD-4.0.0	39	None	0.9399	0.919	35.0	N	-1.794	0.61	0.066339	-1.671	0.2324	-0.6559	0.615612516959	0.855	1.0	0.548	0.630156806279	1.0	0.789732933044	-10.1	0.5	0.839	0.063	None	None	2.23073E-05	2.66581E-05	0	0	0	None	0	0	2.23073E-05	1.69523E-06	3.4036E-04	1.60067E-05	None	N	None
31445	38	V/I	rs564410456	0.1112	gnomAD-2.1.1	40	None	0.0749	0.0677	24.6	N	-0.666	0.17	0.004312	-0.979	0.1149	-0.9251	0.0706192734653	0.175	0.798469	0.565	0.39798585902	0.011	0.411021053791	-0.33	0.145	0.206	0.438	None	None	8.03E-06	0	0	0	1.11309E-04	None	0	None	8.03E-06	0	0	0	None	N	None
31445	38	V/I	rs564410456	0.1112	gnomAD-3.1.2	40	None	0.0749	0.0677	24.6	N	-0.666	0.17	0.004312	-0.979	0.1149	-0.9251	0.0706192734653	0.175	0.798469	0.565	0.39798585902	0.011	0.411021053791	-0.33	0.145	0.206	0.438	None	None	6.57E-06	0	0	0	1.93125E-04	None	0	0	6.57E-06	0	0	0	None	N	None
31445	38	V/I	rs564410456	0.1112	1000 genomes	40	None	0.0749	0.0677	24.6	N	-0.666	0.17	0.004312	-0.979	0.1149	-0.9251	0.0706192734653	0.175	0.798469	0.565	0.39798585902	0.011	0.411021053791	-0.33	0.145	0.206	0.438	None	None	1.99681E-04	0	0	None	1E-03	0	None	None	1.99681E-04	None	0	None	None	N	None
31445	38	V/I	rs564410456	0.1112	gnomAD-4.0.0	40	None	0.0749	0.0677	24.6	N	-0.666	0.17	0.004312	-0.979	0.1149	-0.9251	0.0706192734653	0.175	0.798469	0.565	0.39798585902	0.011	0.411021053791	-0.33	0.145	0.206	0.438	None	None	3.09824E-06	0	0	0	8.91623E-05	None	0	0	3.09824E-06	8.47621E-07	0	0	None	N	None
31445	38	V/L	rs564410456	0.1112	gnomAD-2.1.1	40	None	0.3451	0.2821	25.1	N	-0.669	-0.07	0.024993	-0.979	0.1737	-0.7555	0.129028637738	1.26	0.930306	0.646	0.416581338634	0.437	0.539379119873	-1.87	0.191	0.365	0.191	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.87E-06	0	None	N	None
31445	38	V/L	rs564410456	0.1112	gnomAD-4.0.0	40	None	0.3451	0.2821	25.1	N	-0.669	-0.07	0.024993	-0.979	0.1737	-0.7555	0.129028637738	1.26	0.930306	0.646	0.416581338634	0.437	0.539379119873	-1.87	0.191	0.365	0.191	None	None	6.84202E-07	0	0	0	0	None	0	0	6.84202E-07	8.99481E-07	0	0	None	N	None
31446	39	E/A	None	0.1240	gnomAD-4.0.0	41	None	0.9744	0.9716	35.0	D	None	0.33	0.113969	-0.913	0.5691	0.4709	0.476869963243	3.54	1.0	0.564	0.481915485015	0.999	0.52615737915	-5.0	0.551	0.701	None	None	None	1.5912E-06	0	0	0	0	None	0	0	1.5912E-06	2.85827E-06	0	0	None	N	None
31447	40	K/N	rs1169915824	0.1809	gnomAD-2.1.1	42	None	0.9735	0.9636	32.0	N	-2.251	0.38	0.01618	-2.192	0.401	-0.0666	0.451365656779	3.505	0.999999	0.616	0.346315397577	0.993	0.702548265457	-3.87	0.368	0.799	0.005	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
31447	40	K/N	rs1169915824	0.1809	gnomAD-4.0.0	42	None	0.9735	0.9636	32.0	N	-2.251	0.38	0.01618	-2.192	0.401	-0.0666	0.451365656779	3.505	0.999999	0.616	0.346315397577	0.993	0.702548265457	-3.87	0.368	0.799	0.005	None	None	1.59119E-06	0	2.28634E-05	0	0	None	0	0	1.59119E-06	0	0	0	None	N	None
31448	41	K/N	rs1475927387	0.1089	gnomAD-4.0.0	43	None	0.9982	0.9982	29.5	N	None	0.31	0.040401	-1.812	0.3898	-0.2295	0.500188843923	2.26	0.999988	0.588	0.268211541103	1.0	0.715093135834	-3.97	0.434	0.735	0.003	None	None	1.36839E-06	0	0	0	0	None	0	0	1.36839E-06	1.79893E-06	0	0	None	N	None
31449	42	E/K	rs374474093	0.1864	gnomAD-2.1.1	44	None	0.9831	0.9811	34.0	N	-0.659	0.39	0.017149	-0.703	0.3226	-0.4968	0.489131336793	1.305	1.0	0.622	0.392855499163	0.999	0.760921418667	-3.13	0.41	0.576	0.007	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.87E-06	0	None	N	None
31449	42	E/K	rs374474093	0.1864	gnomAD-4.0.0	44	None	0.9831	0.9811	34.0	N	-0.659	0.39	0.017149	-0.703	0.3226	-0.4968	0.489131336793	1.305	1.0	0.622	0.392855499163	0.999	0.760921418667	-3.13	0.41	0.576	0.007	None	None	6.84196E-07	0	0	0	0	None	0	0	6.84196E-07	8.99468E-07	0	0	None	N	None
31449	42	E/Q	rs374474093	0.1864	gnomAD-2.1.1	44	None	0.9153	0.9105	None	N	-0.915	None	None	-1.058	None	None	None	None	None	None	None	1.0	None	None	0.423	0.619	None	None	None	4.02E-06	6.46E-05	0	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
31450	43	R/C	rs541040798	0.5660	gnomAD-2.1.1	50	None	0.7184	0.7254	35.0	N	-0.081	0.47	0.059571	-0.166	0.3624	-0.2048	0.509567048614	2.405	1.0	0.56	0.553833332621	1.0	0.733350217342	-6.35	0.41	0.701	0.002	None	None	3.24608E-04	0	0	0	0	None	2.67956E-03	None	3.24608E-04	0	6.24E-05	1.40331E-04	None	N	None
31450	43	R/C	rs541040798	0.5660	gnomAD-3.1.2	50	None	0.7184	0.7254	35.0	N	-0.081	0.47	0.059571	-0.166	0.3624	-0.2048	0.509567048614	2.405	1.0	0.56	0.553833332621	1.0	0.733350217342	-6.35	0.41	0.701	0.002	None	None	9.21E-05	0	0	0	0	None	0	0	9.21E-05	4.41E-05	2.07641E-03	4.80307E-04	None	N	None
31450	43	R/C	rs541040798	0.5660	1000 genomes	50	None	0.7184	0.7254	35.0	N	-0.081	0.47	0.059571	-0.166	0.3624	-0.2048	0.509567048614	2.405	1.0	0.56	0.553833332621	1.0	0.733350217342	-6.35	0.41	0.701	0.002	None	None	3.99361E-04	0	0	None	0	0	None	None	3.99361E-04	None	2E-03	None	None	N	None
31450	43	R/C	rs541040798	0.5660	gnomAD-4.0.0	50	None	0.7184	0.7254	35.0	N	-0.081	0.47	0.059571	-0.166	0.3624	-0.2048	0.509567048614	2.405	1.0	0.56	0.553833332621	1.0	0.733350217342	-6.35	0.41	0.701	0.002	None	None	1.59878E-04	0	0	0	4.45851E-05	None	0	1.64962E-04	1.59878E-04	2.37334E-05	2.3718E-03	1.76101E-04	None	N	None
31450	43	R/H	rs751985617	0.5660	gnomAD-2.1.1	50	None	0.5084	0.5266	34.0	N	-1.003	0.41	0.017989	-0.916	0.3555	-0.388	0.48581695538	2.06	1.0	0.54	0.374613414588	0.998	0.692789614201	-4.0	0.414	0.511	0.012	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.87E-06	0	None	N	None
31450	43	R/H	rs751985617	0.5660	gnomAD-4.0.0	50	None	0.5084	0.5266	34.0	N	-1.003	0.41	0.017989	-0.916	0.3555	-0.388	0.48581695538	2.06	1.0	0.54	0.374613414588	0.998	0.692789614201	-4.0	0.414	0.511	0.012	None	None	3.421E-06	0	0	0	0	None	0	0	3.421E-06	4.49738E-06	0	0	None	N	None
31452	45	T/K	rs1270325139	0.2677	gnomAD-2.1.1	60	None	0.8502	0.8364	35.0	N	-0.546	0.61	0.027504	-0.481	0.2587	-0.6578	0.467995876995	1.225	0.999991	0.544	0.370608029945	0.999	0.715213656425	-4.55	0.372	0.551	0.089	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	0	1.65508E-04	None	N	None
31452	45	T/K	rs1270325139	0.2677	gnomAD-4.0.0	60	None	0.8502	0.8364	35.0	N	-0.546	0.61	0.027504	-0.481	0.2587	-0.6578	0.467995876995	1.225	0.999991	0.544	0.370608029945	0.999	0.715213656425	-4.55	0.372	0.551	0.089	None	None	1.59117E-06	0	0	0	0	None	1.88239E-05	0	1.59117E-06	0	0	0	None	N	None
31453	46	I/F	rs780232811	1.0897	gnomAD-2.1.1	63	None	0.8502	0.813	33.0	N	-0.498	0.42	0.03009	-0.592	0.3293	-0.3958	0.578833641793	2.35	1.0	0.473	0.652986081711	1.0	0.779173433781	-2.67	0.411	0.649	0.006	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	I	None
31453	46	I/F	rs780232811	1.0897	gnomAD-4.0.0	63	None	0.8502	0.813	33.0	N	-0.498	0.42	0.03009	-0.592	0.3293	-0.3958	0.578833641793	2.35	1.0	0.473	0.652986081711	1.0	0.779173433781	-2.67	0.411	0.649	0.006	None	None	6.84196E-07	0	2.23604E-05	0	0	None	0	0	6.84196E-07	0	0	0	None	I	None
31453	46	I/V	rs780232811	1.0897	gnomAD-3.1.2	63	None	0.3315	0.2762	29.6	N	None	0.47	0.015249	-0.316	0.258	-0.575	0.422359933901	1.31	0.999998	0.443	0.511047945453	0.993	0.714045405388	-0.7	0.215	0.494	0.272	None	None	1.31E-05	0	1.30907E-04	0	0	None	0	0	1.31E-05	0	0	0	None	I	None
31453	46	I/V	rs780232811	1.0897	gnomAD-4.0.0	63	None	0.3315	0.2762	29.6	N	None	0.47	0.015249	-0.316	0.258	-0.575	0.422359933901	1.31	0.999998	0.443	0.511047945453	0.993	0.714045405388	-0.7	0.215	0.494	0.272	None	None	4.33778E-06	0	5E-05	0	0	None	0	0	4.33778E-06	3.39042E-06	0	0	None	I	None
31454	47	L/F	rs758766295	0.7493	gnomAD-2.1.1	64	None	0.7551	0.7031	33.0	N	-0.519	0.38	0.035264	-0.607	0.2784	-0.5249	0.482416341566	2.185	0.999981	0.474	0.628150982837	1.0	0.791260242462	-3.03	0.31	0.577	0.027	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	I	None
31454	47	L/F	rs758766295	0.7493	gnomAD-4.0.0	64	None	0.7551	0.7031	33.0	N	-0.519	0.38	0.035264	-0.607	0.2784	-0.5249	0.482416341566	2.185	0.999981	0.474	0.628150982837	1.0	0.791260242462	-3.03	0.31	0.577	0.027	None	None	5.47357E-06	0	0	0	0	None	0	0	5.47357E-06	0	9.2745E-05	0	None	I	None
31454	47	L/I	rs758766295	0.7493	gnomAD-2.1.1	64	None	0.3896	0.3488	32.0	N	-0.13	0.39	0.017439	-0.355	0.2618	-0.5716	0.481209393752	1.635	0.999815	0.473	0.559044820595	0.999	0.79694879055	-1.57	0.253	0.471	0.036	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.87E-06	0	None	I	None
31454	47	L/I	rs758766295	0.7493	gnomAD-3.1.2	64	None	0.3896	0.3488	32.0	N	-0.13	0.39	0.017439	-0.355	0.2618	-0.5716	0.481209393752	1.635	0.999815	0.473	0.559044820595	0.999	0.79694879055	-1.57	0.253	0.471	0.036	None	None	6.57E-06	0	0	2.88184E-04	0	None	0	0	6.57E-06	0	0	0	None	I	None
31454	47	L/I	rs758766295	0.7493	gnomAD-4.0.0	64	None	0.3896	0.3488	32.0	N	-0.13	0.39	0.017439	-0.355	0.2618	-0.5716	0.481209393752	1.635	0.999815	0.473	0.559044820595	0.999	0.79694879055	-1.57	0.253	0.471	0.036	None	None	2.4788E-06	0	0	1.01365E-04	0	None	0	0	2.4788E-06	8.47606E-07	0	0	None	I	None
31455	48	W/G	None	0.2085	gnomAD-4.0.0	65	None	0.9956	0.9941	35.0	D	None	0.47	0.243843	-3.221	0.5329	0.4236	0.615072577956	4.16	1.0	0.845	0.524792858863	1.0	0.85011780262	-10.53	0.685	0.643	None	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
31455	48	W/R	rs1697563457	0.2085	gnomAD-4.0.0	65	None	0.9998	0.9997	35.0	D	None	0.48	0.161847	-0.946	0.5329	0.4236	0.615612516959	4.16	1.0	0.851	0.799177201931	1.0	0.886573195457	-11.2	0.639	0.721	None	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
31456	49	V/M	rs1559156264	0.4323	gnomAD-2.1.1	66	None	0.1466	0.1375	28.8	N	None	0.34	0.027762	-0.444	0.2521	-0.6377	0.424484034858	1.025	1.0	0.474	0.571728244252	0.983	0.634540438652	-2.12	0.27	0.527	0.009	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.87E-06	0	None	I	None
31456	49	V/M	rs1559156264	0.4323	gnomAD-3.1.2	66	None	0.1466	0.1375	28.8	N	None	0.34	0.027762	-0.444	0.2521	-0.6377	0.424484034858	1.025	1.0	0.474	0.571728244252	0.983	0.634540438652	-2.12	0.27	0.527	0.009	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	I	None
31456	49	V/M	rs1559156264	0.4323	gnomAD-4.0.0	66	None	0.1466	0.1375	28.8	N	None	0.34	0.027762	-0.444	0.2521	-0.6377	0.424484034858	1.025	1.0	0.474	0.571728244252	0.983	0.634540438652	-2.12	0.27	0.527	0.009	None	None	2.56218E-06	1.6913E-05	0	0	0	None	0	0	2.56218E-06	2.393E-06	0	0	None	I	None
31458	51	E/G	rs763832963	0.1834	gnomAD-2.1.1	68	None	0.4362	0.4188	35.0	N	-1.331	0.38	0.04404	-0.857	0.1966	-0.68	0.436864047916	1.04	1.0	0.615	0.369309618794	0.993	0.720951199532	-5.13	0.492	0.714	0.236	None	None	8.03E-06	0	0	0	0	None	0	None	8.03E-06	0	1.77E-05	0	None	I	None
31458	51	E/G	rs763832963	0.1834	gnomAD-4.0.0	68	None	0.4362	0.4188	35.0	N	-1.331	0.38	0.04404	-0.857	0.1966	-0.68	0.436864047916	1.04	1.0	0.615	0.369309618794	0.993	0.720951199532	-5.13	0.492	0.714	0.236	None	None	3.18238E-06	0	0	0	0	None	0	0	3.18238E-06	5.71644E-06	0	0	None	I	None
31458	51	E/K	rs1697558384	0.1834	gnomAD-4.0.0	68	None	0.6826	0.655	35.0	N	None	0.44	0.022179	-0.48	0.225	-0.7116	0.368983407752	1.295	1.0	0.677	0.326616659874	0.977	0.810120046139	-2.85	0.384	0.497	0.428	None	None	1.5912E-06	0	0	0	0	None	0	0	1.5912E-06	2.85827E-06	0	0	None	I	None
31460	53	K/Q	None	0.9864	gnomAD-4.0.0	70	None	0.1753	0.212	34.0	N	None	0.42	0.015434	-0.21	0.2845	-0.5209	0.478647829999	1.43	0.999999	0.537	0.28798054836	1.0	0.607558131218	-2.85	0.396	0.727	0.015	None	None	1.36839E-06	2.98829E-05	0	0	0	None	0	0	1.36839E-06	0	0	1.65667E-05	None	I	None
31460	53	K/R	None	0.9864	gnomAD-4.0.0	70	None	0.0799	0.0802	35.0	N	None	0.48	0.010004	-0.12	0.2284	-0.6013	0.423302696435	1.23	0.999999	0.517	0.379366414296	0.999	0.582423210144	-2.37	0.33	0.603	0.075	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
31461	54	V/L	rs1206905148	0.6322	gnomAD-3.1.2	72	None	0.1116	0.1023	24.0	N	None	0.4	0.008315	-0.32	0.0929	-1.0036	0.0821069030307	0.075	0.891785	0.477	0.213573922156	0.001	0.468573272228	-1.77	0.098	0.093	0.081	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
31461	54	V/L	rs1206905148	0.6322	gnomAD-4.0.0	72	None	0.1116	0.1023	24.0	N	None	0.4	0.008315	-0.32	0.0929	-1.0036	0.0821069030307	0.075	0.891785	0.477	0.213573922156	0.001	0.468573272228	-1.77	0.098	0.093	0.081	None	None	6.57307E-06	0	0	0	0	None	0	0	6.57307E-06	1.47037E-05	0	0	None	I	None
31462	55	P/A	None	0.2327	gnomAD-4.0.0	75	None	0.1058	0.1283	25.0	N	None	0.45	0.018073	-1.438	0.1746	-0.8413	0.0913205535873	2.02	0.999997	0.568	0.191931220699	0.058	0.674263358116	-6.02	0.231	0.289	0.044	None	None	6.84202E-07	0	0	0	0	None	0	0	6.84202E-07	8.99475E-07	0	0	None	N	None
31462	55	P/S	rs1311115144	0.2327	gnomAD-4.0.0	75	None	0.3495	0.4518	25.7	N	None	0.44	0.027253	-1.585	0.1753	-0.8267	0.102169319623	1.67	0.999998	0.558	0.199424873507	0.126	0.682293355465	-6.13	0.219	0.267	0.119	None	None	6.84202E-07	0	0	0	2.51915E-05	None	0	0	6.84202E-07	0	0	0	None	N	None
31462	55	P/T	rs1311115144	0.2327	gnomAD-3.1.2	75	None	0.2627	0.3576	25.9	N	-1.222	0.35	0.027149	-1.371	0.2242	-0.6492	0.285142599056	1.58	0.999998	0.533	0.389596023526	0.698	0.711883425713	-6.22	0.316	0.575	0.036	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
31462	55	P/T	rs1311115144	0.2327	gnomAD-4.0.0	75	None	0.2627	0.3576	25.9	N	-1.222	0.35	0.027149	-1.371	0.2242	-0.6492	0.285142599056	1.58	0.999998	0.533	0.389596023526	0.698	0.711883425713	-6.22	0.316	0.575	0.036	None	None	6.5754E-06	0	0	0	0	None	0	0	6.5754E-06	1.4702E-05	0	0	None	N	None
31463	56	C/G	None	0.1345	gnomAD-4.0.0	77	None	0.3745	0.4199	33.0	N	None	0.49	0.031007	-2.029	0.2284	-0.6013	0.515532960109	0.55	1.0	0.542	0.782932109435	1.0	0.77836894989	-8.53	0.499	0.758	None	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
31463	56	C/Y	rs760317660	0.1345	gnomAD-2.1.1	77	None	0.5852	0.68	35.0	N	-1.374	0.46	0.015242	-1.137	0.3135	-0.5177	0.600679684098	1.385	1.0	0.537	0.676867754606	1.0	0.868780851364	-7.99	0.383	0.819	0.001	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.87E-06	0	None	N	None
31465	58	E/K	rs752194452	0.6752	gnomAD-2.1.1	88	None	0.248	0.3245	32.0	N	0.288	0.43	0.029077	0.072	0.225	-0.7116	0.368983407752	0.695	1.0	0.63	0.286848849266	0.977	0.730165243149	-2.7	0.386	0.598	0.14	None	None	1.07E-05	0	0	0	0	None	0	None	1.07E-05	0	2.34E-05	0	None	I	None
31465	58	E/K	rs752194452	0.6752	gnomAD-3.1.2	88	None	0.248	0.3245	32.0	N	0.288	0.43	0.029077	0.072	0.225	-0.7116	0.368983407752	0.695	1.0	0.63	0.286848849266	0.977	0.730165243149	-2.7	0.386	0.598	0.14	None	None	3.94E-05	0	0	0	0	None	0	0	3.94E-05	8.82E-05	0	0	None	I	None
31465	58	E/K	rs752194452	0.6752	gnomAD-4.0.0	88	None	0.248	0.3245	32.0	N	0.288	0.43	0.029077	0.072	0.225	-0.7116	0.368983407752	0.695	1.0	0.63	0.286848849266	0.977	0.730165243149	-2.7	0.386	0.598	0.14	None	None	5.57718E-06	0	0	0	0	None	0	0	5.57718E-06	5.9333E-06	2.19563E-05	0	None	I	None
31465	58	E/Q	None	0.6752	gnomAD-4.0.0	88	None	0.1485	0.172	31.0	N	None	0.4	0.015209	-0.257	0.269	-0.6106	0.41524469658	0.875	1.0	0.501	0.218112801441	0.997	0.638049066067	-2.12	0.299	0.637	0.065	None	None	2.05261E-06	0	0	0	2.51902E-05	None	1.87259E-05	0	2.05261E-06	8.99476E-07	0	0	None	I	None
31466	59	C/G	rs1697549166	0.1215	gnomAD-4.0.0	89	None	0.1423	0.1439	35.0	N	None	0.64	0.05583	-2.461	0.2892	-0.503	0.515532960109	2.405	1.0	0.541	0.816487136085	1.0	0.876281857491	-8.72	0.501	0.779	0.107	None	None	1.59128E-06	0	0	0	0	None	0	0	1.59128E-06	2.85847E-06	0	0	None	I	None
31468	61	Y/C	None	0.2402	gnomAD-4.0.0	91	None	0.1517	0.14	35.0	N	None	0.21	0.035849	-1.325	0.2943	-0.4671	0.468996964068	1.17	0.999967	0.734	0.514866526686	0.993	0.793067574501	-7.1	0.367	0.686	0.003	None	None	4.10523E-06	0	0	0	0	None	0	5.20291E-04	4.10523E-06	2.69843E-06	0	0	None	I	None
31471	64	T/I	rs759347301	0.4819	gnomAD-2.1.1	94	None	0.1442	0.1339	22.8	N	0.044	0.22	0.035235	-0.202	0.1942	-0.7378	0.0924205253006	1.645	0.689557	0.552	0.216624796971	0.001	0.559100985527	-4.04	0.164	0.311	0.02	None	None	1.2E-05	0	5.79E-05	0	0	None	3.27E-05	None	1.2E-05	0	0	0	None	N	None
31471	64	T/I	rs759347301	0.4819	gnomAD-4.0.0	94	None	0.1442	0.1339	22.8	N	0.044	0.22	0.035235	-0.202	0.1942	-0.7378	0.0924205253006	1.645	0.689557	0.552	0.216624796971	0.001	0.559100985527	-4.04	0.164	0.311	0.02	None	None	1.02632E-05	0	4.47227E-05	0	0	None	0	0	1.02632E-05	0	1.04338E-04	6.62691E-05	None	N	None
31472	65	G/S	rs1331080177	0.4836	gnomAD-2.1.1	96	None	0.0971	0.0952	22.1	N	-0.38	0.12	0.040875	-0.813	0.2247	-0.6464	0.110045376786	2.115	0.999634	0.692	0.180583059064	0.489	0.494199097157	-3.6	0.244	0.141	0.025	None	None	8.03E-06	6.46E-05	0	0	0	None	3.27E-05	None	8.03E-06	0	0	0	None	N	None
31472	65	G/S	rs1331080177	0.4836	gnomAD-4.0.0	96	None	0.0971	0.0952	22.1	N	-0.38	0.12	0.040875	-0.813	0.2247	-0.6464	0.110045376786	2.115	0.999634	0.692	0.180583059064	0.489	0.494199097157	-3.6	0.244	0.141	0.025	None	None	2.05263E-06	2.98846E-05	0	0	0	None	0	0	2.05263E-06	0	2.31863E-05	0	None	N	None
31473	66	L/S	None	0.1207	gnomAD-4.0.0	97	None	0.9964	0.9961	35.0	D	None	-1.95	0.084759	-3.132	0.8607	1.0042	0.543900500545	4.115	0.99992	0.824	0.910148523263	1.0	0.659756958485	-5.2	0.867	0.855	None	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
31474	67	V/A	rs1401860835	0.5218	gnomAD-2.1.1	98	None	0.2397	0.2584	27.4	N	-1.051	0.45	0.023656	-1.026	0.1549	-0.8512	0.184178322688	0.97	0.999921	0.447	0.540016403455	0.429	0.532902359962	-3.0	0.239	0.387	0.21	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
31474	67	V/A	rs1401860835	0.5218	gnomAD-4.0.0	98	None	0.2397	0.2584	27.4	N	-1.051	0.45	0.023656	-1.026	0.1549	-0.8512	0.184178322688	0.97	0.999921	0.447	0.540016403455	0.429	0.532902359962	-3.0	0.239	0.387	0.21	None	None	1.59129E-06	0	2.28655E-05	0	0	None	0	0	1.59129E-06	0	0	0	None	N	None
31474	67	V/I	rs1410759884	0.5218	gnomAD-2.1.1	98	None	0.0871	0.0887	24.6	N	-0.283	0.41	0.009403	-0.412	0.073	-1.0404	0.0715876967428	-0.31	0.996665	0.501	0.336155897331	0.002	0.393700063229	-0.6	0.094	0.155	0.219	None	None	7.13E-06	8.27E-05	0	0	0	None	0	None	7.13E-06	0	0	0	None	N	None
31474	67	V/I	rs1410759884	0.5218	gnomAD-3.1.2	98	None	0.0871	0.0887	24.6	N	-0.283	0.41	0.009403	-0.412	0.073	-1.0404	0.0715876967428	-0.31	0.996665	0.501	0.336155897331	0.002	0.393700063229	-0.6	0.094	0.155	0.219	None	None	1.31E-05	4.82E-05	0	0	0	None	0	0	1.31E-05	0	0	0	None	N	None
31474	67	V/I	rs1410759884	0.5218	gnomAD-4.0.0	98	None	0.0871	0.0887	24.6	N	-0.283	0.41	0.009403	-0.412	0.073	-1.0404	0.0715876967428	-0.31	0.996665	0.501	0.336155897331	0.002	0.393700063229	-0.6	0.094	0.155	0.219	None	None	3.84307E-06	5.0734E-05	0	0	0	None	0	0	3.84307E-06	0	0	0	None	N	None
31475	68	E/Q	rs1171182062	0.5002	gnomAD-2.1.1	99	None	0.5326	0.5742	29.7	N	0.206	0.36	0.018703	-0.113	0.4091	-0.2074	0.461673312431	2.5	1.0	0.567	0.294918367191	1.0	0.659854054451	-2.5	0.381	0.661	0.008	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	N	None
31475	68	E/Q	rs1171182062	0.5002	gnomAD-3.1.2	99	None	0.5326	0.5742	29.7	N	0.206	0.36	0.018703	-0.113	0.4091	-0.2074	0.461673312431	2.5	1.0	0.567	0.294918367191	1.0	0.659854054451	-2.5	0.381	0.661	0.008	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
31475	68	E/Q	rs1171182062	0.5002	gnomAD-4.0.0	99	None	0.5326	0.5742	29.7	N	0.206	0.36	0.018703	-0.113	0.4091	-0.2074	0.461673312431	2.5	1.0	0.567	0.294918367191	1.0	0.659854054451	-2.5	0.381	0.661	0.008	None	None	6.57177E-06	0	0	0	0	None	0	0	6.57177E-06	1.46972E-05	0	0	None	N	None
31476	69	G/R	rs1481659337	0.2576	gnomAD-2.1.1	100	None	0.9635	0.9755	34.0	N	-0.427	0.01	0.047835	-0.851	0.5442	0.1656	0.506463245118	2.625	1.0	0.806	0.794042446464	1.0	0.856127798557	-6.3	0.659	0.848	0.002	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.87E-06	0	None	N	None
31476	69	G/R	rs1481659337	0.2576	gnomAD-4.0.0	100	None	0.9635	0.9755	34.0	N	-0.427	0.01	0.047835	-0.851	0.5442	0.1656	0.506463245118	2.625	1.0	0.806	0.794042446464	1.0	0.856127798557	-6.3	0.659	0.848	0.002	None	None	1.5913E-06	0	0	0	0	None	0	0	1.5913E-06	2.85848E-06	0	0	None	N	None
31480	73	Q/E	None	0.1814	gnomAD-4.0.0	105	None	0.2704	0.2696	34.0	N	None	0.54	0.015813	-1.482	0.2512	-0.6007	0.474755460642	0.255	1.0	0.577	0.282179105231	0.992	0.712644338608	-2.23	0.412	0.481	0.334	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
31480	73	Q/H	rs1182145400	0.1814	gnomAD-2.1.1	105	None	0.8203	0.8173	26.1	N	-1.671	0.37	0.027293	-1.128	0.2671	-0.5626	0.45215106663	2.23	0.999907	0.538	0.316494231283	0.999	0.741574406624	-4.17	0.387	0.732	0.012	None	None	4.02E-06	0	0	0	5.57E-05	None	0	None	4.02E-06	0	0	0	None	N	None
31480	73	Q/H	rs1182145400	0.1814	gnomAD-4.0.0	105	None	0.8203	0.8173	26.1	N	-1.671	0.37	0.027293	-1.128	0.2671	-0.5626	0.45215106663	2.23	0.999907	0.538	0.316494231283	0.999	0.741574406624	-4.17	0.387	0.732	0.012	None	None	1.59132E-06	0	0	0	2.77285E-05	None	0	0	1.59132E-06	0	0	0	None	N	None
31481	74	F/L	None	0.1234	gnomAD-4.0.0	106	None	0.9961	0.9966	28.6	N	None	0.23	0.063987	-1.553	0.4465	-0.0134	0.496083062219	3.125	0.999996	0.671	0.433491693731	0.999	0.829562366009	-5.27	0.555	0.682	0.005	None	None	1.16316E-05	0	0	0	0	None	0	0	1.16316E-05	1.43918E-05	0	1.65662E-05	None	N	None
31482	75	R/T	None	0.1301	gnomAD-4.0.0	107	None	0.9975	0.996	28.7	N	None	0.26	0.028487	-1.839	0.4657	-0.0603	0.559873948921	3.795	0.999999	0.796	0.774597630533	1.0	0.751347184181	-5.4	0.58	0.729	0.003	None	None	1.59132E-06	0	0	0	0	None	0	0	1.59132E-06	2.85855E-06	0	0	None	N	None
31488	81	A/D	None	0.6642	gnomAD-4.0.0	113	None	0.4489	0.4353	35.0	N	None	0.4	0.041168	-0.367	0.2486	-0.6225	0.534207440331	0.22	0.999046	0.557	0.577403499239	0.998	0.774632275105	-4.05	0.408	0.599	0.194	None	None	1.59141E-06	0	0	0	0	None	0	0	1.59141E-06	2.85879E-06	0	0	None	I	None
31489	82	A/S	rs773485371	0.5225	gnomAD-2.1.1	114	None	0.2861	0.2606	24.3	N	-0.46	0.34	0.037338	-0.584	0.2674	-0.4985	0.185332253646	2.105	0.999999	0.456	0.237489013734	0.957	0.712014436722	-2.53	0.304	0.443	0.106	None	None	4.02E-06	0	0	0	5.57E-05	None	0	None	4.02E-06	0	0	0	None	I	None
31490	83	G/D	None	0.1991	gnomAD-4.0.0	115	None	0.9836	0.9831	33.0	D	None	-0.32	0.034793	-1.033	0.6305	0.4217	0.527275360279	4.185	1.0	0.871	0.563836457519	1.0	0.862592756748	-6.3	0.671	0.899	0.009	None	None	2.05278E-06	2.98829E-05	0	0	5.03829E-05	None	0	0	2.05278E-06	0	0	0	None	I	None
31490	83	G/R	None	0.1991	gnomAD-4.0.0	115	None	0.9828	0.9825	30.0	D	None	-0.35	0.056189	-0.724	0.6499	0.4989	0.506463245118	3.635	1.0	0.85	0.847646856092	1.0	0.859285593033	-7.2	0.664	0.898	0.002	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
31491	84	V/F	None	0.3311	gnomAD-4.0.0	117	None	0.182	0.1849	23.7	N	None	0.58	0.013075	-1.067	0.1283	-0.954	0.119312659401	0.85	0.957154	0.412	0.717020191167	0.028	0.63916093111	-3.24	0.167	0.39	0.004	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	I	None
31494	87	A/D	rs748231785	0.2089	gnomAD-2.1.1	120	None	0.9351	0.9313	35.0	N	-1.644	0.54	0.040134	-0.83	0.3666	-0.2843	0.485240330624	2.495	1.0	0.465	0.575848135552	0.997	0.765582680702	-4.33	0.472	0.739	0.022	None	None	4.03E-06	0	2.9E-05	0	0	None	0	None	4.03E-06	0	0	0	None	I	None
31494	87	A/D	rs748231785	0.2089	gnomAD-4.0.0	120	None	0.9351	0.9313	35.0	N	-1.644	0.54	0.040134	-0.83	0.3666	-0.2843	0.485240330624	2.495	1.0	0.465	0.575848135552	0.997	0.765582680702	-4.33	0.472	0.739	0.022	None	None	3.18423E-06	0	4.5731E-05	0	0	None	0	0	3.18423E-06	0	0	0	None	I	None
31494	87	A/T	rs769948504	0.2089	gnomAD-2.1.1	120	None	0.36	0.3749	34.0	N	-1.252	0.57	0.02854	-1.079	0.2674	-0.5861	0.355027518676	1.945	0.999981	0.398	0.37097340754	0.977	0.696608304977	-2.87	0.184	0.608	0.049	None	None	8.05E-06	0	0	0	0	None	6.54E-05	None	8.05E-06	0	0	0	None	I	None
31494	87	A/T	rs769948504	0.2089	gnomAD-4.0.0	120	None	0.36	0.3749	34.0	N	-1.252	0.57	0.02854	-1.079	0.2674	-0.5861	0.355027518676	1.945	0.999981	0.398	0.37097340754	0.977	0.696608304977	-2.87	0.184	0.608	0.049	None	None	5.4749E-06	0	0	0	0	None	0	0	5.4749E-06	0	8.11726E-05	1.65684E-05	None	I	None
31495	88	S/N	rs1329167679	0.1147	gnomAD-3.1.2	121	None	0.9776	0.9752	32.0	D	None	-0.54	0.038159	-1.31	0.7091	0.6495	0.448649923726	3.68	1.0	0.566	0.502254315933	0.999	0.738329470158	-2.42	0.587	0.889	0.006	None	None	1.31E-05	4.82E-05	0	0	0	None	0	0	1.31E-05	0	0	0	None	N	None
31495	88	S/N	rs1329167679	0.1147	gnomAD-4.0.0	121	None	0.9776	0.9752	32.0	D	None	-0.54	0.038159	-1.31	0.7091	0.6495	0.448649923726	3.68	1.0	0.566	0.502254315933	0.999	0.738329470158	-2.42	0.587	0.889	0.006	None	None	2.47939E-06	2.66944E-05	0	0	0	None	0	0	2.47939E-06	1.69573E-06	0	0	None	N	None
31496	89	E/K	rs769175534	0.4535	gnomAD-2.1.1	122	None	0.6543	0.6128	34.0	N	-0.12	0.46	0.035493	0.38	0.1755	-0.7345	0.314226086246	1.23	1.0	0.402	0.327686398923	0.998	0.793040394783	-3.52	0.365	0.58	0.135	None	None	2.82E-05	0	2.9E-05	0	0	None	3.27E-05	None	2.82E-05	4.66E-05	2.67E-05	1.66113E-04	None	N	None
31496	89	E/K	rs769175534	0.4535	gnomAD-3.1.2	122	None	0.6543	0.6128	34.0	N	-0.12	0.46	0.035493	0.38	0.1755	-0.7345	0.314226086246	1.23	1.0	0.402	0.327686398923	0.998	0.793040394783	-3.52	0.365	0.58	0.135	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
31496	89	E/K	rs769175534	0.4535	gnomAD-4.0.0	122	None	0.6543	0.6128	34.0	N	-0.12	0.46	0.035493	0.38	0.1755	-0.7345	0.314226086246	1.23	1.0	0.402	0.327686398923	0.998	0.793040394783	-3.52	0.365	0.58	0.135	None	None	1.30175E-05	0	5.00183E-05	0	2.22806E-05	None	0	0	1.30175E-05	1.01747E-05	2.1964E-05	4.8043E-05	None	N	None
31496	89	E/Q	None	0.4535	gnomAD-4.0.0	122	None	0.4928	0.4571	33.0	N	None	0.47	0.017565	0.064	0.3167	-0.4994	0.417156267166	1.955	1.0	0.259	0.412587454835	1.0	0.719048142433	-2.62	0.253	0.603	0.014	None	None	6.84448E-07	0	0	0	0	None	0	0	6.84448E-07	8.99782E-07	0	0	None	N	None
31497	90	A/T	rs1371205000	0.1894	gnomAD-2.1.1	123	None	0.2316	0.2239	35.0	N	-1.482	0.62	0.035071	-1.341	0.217	-0.7446	0.386515749672	1.0	1.0	0.253	0.29527378943	0.998	0.654261112213	-2.3	0.245	0.758	0.477	None	None	4.03E-06	0	0	0	0	None	3.27E-05	None	4.03E-06	0	0	0	None	N	None
31497	90	A/T	rs1371205000	0.1894	gnomAD-3.1.2	123	None	0.2316	0.2239	35.0	N	-1.482	0.62	0.035071	-1.341	0.217	-0.7446	0.386515749672	1.0	1.0	0.253	0.29527378943	0.998	0.654261112213	-2.3	0.245	0.758	0.477	None	None	6.57E-06	0	6.55E-05	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
31497	90	A/T	rs1371205000	0.1894	gnomAD-4.0.0	123	None	0.2316	0.2239	35.0	N	-1.482	0.62	0.035071	-1.341	0.217	-0.7446	0.386515749672	1.0	1.0	0.253	0.29527378943	0.998	0.654261112213	-2.3	0.245	0.758	0.477	None	None	2.56464E-06	0	1.69549E-05	0	0	None	0	0	2.56464E-06	0	1.34081E-05	0	None	N	None
31498	91	S/L	rs1281357207	0.1178	gnomAD-2.1.1	124	None	0.8892	0.8805	35.0	N	0.215	0.66	0.052897	0.282	0.432	-0.0115	0.436907008379	3.345	1.0	0.342	0.425970041486	0.999	0.645997047424	-5.07	0.444	0.651	0.003	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.91E-06	0	None	I	None
31498	91	S/L	rs1281357207	0.1178	gnomAD-4.0.0	124	None	0.8892	0.8805	35.0	N	0.215	0.66	0.052897	0.282	0.432	-0.0115	0.436907008379	3.345	1.0	0.342	0.425970041486	0.999	0.645997047424	-5.07	0.444	0.651	0.003	None	None	1.36918E-06	0	0	0	0	None	0	0	1.36918E-06	1.7999E-06	0	0	None	I	None
31499	92	R/I	None	0.8855	gnomAD-4.0.0	125	None	0.5141	0.5441	34.0	N	None	0.65	0.033282	0.431	0.2466	-0.6695	0.612490174142	1.59	1.0	0.438	0.375861065471	0.999	0.6983948946	-6.31	0.404	0.779	0.011	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
31500	93	P/L	None	0.3955	gnomAD-4.0.0	126	None	0.3065	0.3737	34.0	N	None	0.7	0.051899	-0.456	0.1967	-0.7136	0.231389412655	1.72	1.0	0.392	0.388010793773	0.949	0.741712391376	-7.23	0.334	0.812	0.359	None	None	1.36998E-06	0	0	0	0	None	0	0	1.36998E-06	1.80089E-06	0	0	None	N	None
31500	93	P/R	rs747518732	0.3955	gnomAD-2.1.1	126	None	0.6671	0.7714	34.0	N	-0.179	0.59	0.034288	-0.192	0.3027	-0.4619	0.339819452969	2.16	0.999997	0.319	0.481616744073	0.987	0.740430891514	-6.43	0.353	0.901	0.271	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.92E-06	0	None	N	None
31500	93	P/R	rs747518732	0.3955	gnomAD-3.1.2	126	None	0.6671	0.7714	34.0	N	-0.179	0.59	0.034288	-0.192	0.3027	-0.4619	0.339819452969	2.16	0.999997	0.319	0.481616744073	0.987	0.740430891514	-6.43	0.353	0.901	0.271	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
31500	93	P/R	rs747518732	0.3955	gnomAD-4.0.0	126	None	0.6671	0.7714	34.0	N	-0.179	0.59	0.034288	-0.192	0.3027	-0.4619	0.339819452969	2.16	0.999997	0.319	0.481616744073	0.987	0.740430891514	-6.43	0.353	0.901	0.271	None	None	1.86097E-06	0	0	0	0	None	0	0	1.86097E-06	2.54542E-06	0	0	None	N	None
31500	93	P/S	None	0.3955	gnomAD-4.0.0	126	None	0.2474	0.2832	32.0	N	None	0.62	0.037479	-0.876	0.1641	-0.7127	0.186135402304	1.2	0.999929	0.243	0.359557344763	0.949	0.688314557076	-5.6	0.182	0.833	0.249	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
31501	94	I/L	None	0.3314	gnomAD-4.0.0	127	None	0.0651	0.0773	19.98	N	None	0.62	0.008527	-0.872	0.0835	-0.9701	0.0828097219052	0.69	0.999866	0.254	0.15556083564	None	0.291360497475	-1.44	0.087	0.237	0.12	None	None	6.84981E-07	0	0	0	0	None	0	0	6.84981E-07	9.00416E-07	0	0	None	N	None
31501	94	I/T	rs758756316	0.3314	gnomAD-2.1.1	127	None	0.1453	0.1295	24.3	N	-2.273	0.74	0.03658	-1.942	0.1673	-0.8879	0.108086438741	0.5	0.980408	0.451	0.596874347621	0.006	0.346404582262	-3.45	0.158	0.491	0.035	None	None	1.21E-05	0	0	0	0	None	0	None	1.21E-05	0	2.68E-05	0	None	N	None
31501	94	I/T	rs758756316	0.3314	gnomAD-4.0.0	127	None	0.1453	0.1295	24.3	N	-2.273	0.74	0.03658	-1.942	0.1673	-0.8879	0.108086438741	0.5	0.980408	0.451	0.596874347621	0.006	0.346404582262	-3.45	0.158	0.491	0.035	None	None	2.55288E-05	0	0	0	3.32926E-04	None	0	0	2.55288E-05	1.14726E-05	0	0	None	N	None
31501	94	I/V	rs780578358	0.3314	gnomAD-2.1.1	127	None	0.0474	0.0452	18.63	N	-1.234	0.65	0.010631	-1.195	0.0503	-1.0164	0.0703051542146	-0.985	0.999935	0.225	0.110078149338	None	0.268763631582	-0.38	0.076	0.177	0.981	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	4.67E-05	0	0	None	N	None
31501	94	I/V	rs780578358	0.3314	gnomAD-3.1.2	127	None	0.0474	0.0452	18.63	N	-1.234	0.65	0.010631	-1.195	0.0503	-1.0164	0.0703051542146	-0.985	0.999935	0.225	0.110078149338	None	0.268763631582	-0.38	0.076	0.177	0.981	None	None	1.31E-05	0	0	0	0	None	9.41E-05	0	1.31E-05	1.47E-05	0	0	None	N	None
31501	94	I/V	rs780578358	0.3314	gnomAD-4.0.0	127	None	0.0474	0.0452	18.63	N	-1.234	0.65	0.010631	-1.195	0.0503	-1.0164	0.0703051542146	-0.985	0.999935	0.225	0.110078149338	None	0.268763631582	-0.38	0.076	0.177	0.981	None	None	7.44366E-06	0	0	0	0	None	1.40757E-04	0	7.44366E-06	2.54535E-06	0	0	None	N	None
31502	95	M/T	None	0.2747	gnomAD-4.0.0	129	None	0.1429	0.1581	28.9	N	None	1.21	0.01211	-0.566	0.0346	-1.0193	0.0987704213746	-0.375	0.999585	0.275	0.413241256734	0.023	0.588077425957	-3.58	0.243	0.391	0.427	None	None	1.20033E-06	0	0	0	0	None	0	0	1.20033E-06	1.31251E-06	0	0	None	N	None
31503	96	A/T	rs375657115	0.0614	gnomAD-2.1.1	130	None	0.8523	0.7836	None	N	-1.946	None	None	-1.833	None	None	None	None	None	None	None	1.0	None	None	0.336	0.787	None	None	None	5.04E-05	0	1.14116E-04	0	0	None	0	None	5.04E-05	0	7.1E-05	1.41924E-04	None	N	None
31503	96	A/T	rs375657115	0.0614	gnomAD-3.1.2	130	None	0.8523	0.7836	None	N	-1.946	None	None	-1.833	None	None	None	None	None	None	None	1.0	None	None	0.336	0.787	None	None	None	4.6E-05	0	1.96592E-04	0	0	None	0	0	4.6E-05	2.94E-05	0	9.56023E-04	None	N	None
31503	96	A/T	rs375657115	0.0614	1000 genomes	130	None	0.8523	0.7836	None	N	-1.946	None	None	-1.833	None	None	None	None	None	None	None	1.0	None	None	0.336	0.787	None	None	None	1.99681E-04	0	1.4E-03	None	0	0	None	None	1.99681E-04	None	0	None	None	N	None
31503	96	A/T	rs375657115	0.0614	gnomAD-4.0.0	130	None	0.8523	0.7836	None	N	-1.946	None	None	-1.833	None	None	None	None	None	None	None	1.0	None	None	0.336	0.787	None	None	None	5.28468E-05	1.33683E-05	1.67616E-04	0	0	None	0	1.65893E-04	5.28468E-05	5.35643E-05	0	1.60705E-04	None	N	None
31504	97	Q/P	rs777578106	0.3893	gnomAD-2.1.1	131	None	0.9045	0.9181	35.0	N	-0.042	0.64	0.030576	0.087	0.1469	-0.8567	0.348985493355	0.87	0.999998	0.375	0.27132560031	0.991	0.534528613091	-4.03	0.234	0.493	0.107	None	None	8.11E-06	0	5.83E-05	0	0	None	0	None	8.11E-06	0	0	0	None	N	None
31504	97	Q/P	rs777578106	0.3893	gnomAD-4.0.0	131	None	0.9045	0.9181	35.0	N	-0.042	0.64	0.030576	0.087	0.1469	-0.8567	0.348985493355	0.87	0.999998	0.375	0.27132560031	0.991	0.534528613091	-4.03	0.234	0.493	0.107	None	None	3.208E-06	0	4.59918E-05	0	0	None	0	0	3.208E-06	0	0	0	None	N	None
31505	98	N/T	rs755756435	0.6393	gnomAD-2.1.1	132	None	0.3732	0.4358	34.0	N	0.437	0.62	0.022581	0.012	0.3157	-0.3877	0.462432038134	1.67	1.0	0.247	0.380564188046	0.997	0.702482581139	-4.63	0.285	0.723	0.015	None	None	1.22E-05	0	0	0	0	None	9.94E-05	None	1.22E-05	0	0	0	None	I	None
31505	98	N/T	rs755756435	0.6393	gnomAD-4.0.0	132	None	0.3732	0.4358	34.0	N	0.437	0.62	0.022581	0.012	0.3157	-0.3877	0.462432038134	1.67	1.0	0.247	0.380564188046	0.997	0.702482581139	-4.63	0.285	0.723	0.015	None	None	3.43351E-06	0	0	0	0	None	0	0	3.43351E-06	0	5.82099E-05	0	None	I	None

Whole Population MAF	African (AFR)	Latin American (AMR)
Amish (AMS)	Ashkenazi Jewish (ASJ)	East Asian (EAS)
European/1KGP (EUR)	Finnish (FIN)	Middle Eastern (MDE)
Non-Finnish European (NFE)	South Asian (SAS)	Other (OTH)

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