TITINdb

Map SAVs to Structure

Position	Domain position	SAV	Structural Position	RS	Q(SASA)	Disease	Source	MAF
16651	1	P/H	1	None	0.4222	None	gnomAD-4.0.0	6.89576E-07
16651	1	P/S	1	rs537759268	0.4222	None	gnomAD-3.1.2	6.65E-06
16651	1	P/S	1	rs537759268	0.4222	None	gnomAD-4.0.0	2.50083E-06
16651	1	P/T	1	rs537759268	0.4222	None	gnomAD-2.1.1	4.36E-06
16651	1	P/T	1	rs537759268	0.4222	None	1000 genomes	1.99681E-04
16653	3	S/L	3	rs746669146	0.1898	None	gnomAD-2.1.1	8.44E-06
16653	3	S/L	3	rs746669146	0.1898	None	gnomAD-4.0.0	4.82916E-06
16654	4	P/A	4	rs1362265469	0.2639	None	gnomAD-2.1.1	4.21E-06
16654	4	P/A	4	rs1362265469	0.2639	None	gnomAD-4.0.0	1.60804E-06
16654	4	P/S	4	rs1362265469	0.2639	None	gnomAD-2.1.1	4.21E-06
16654	4	P/S	4	rs1362265469	0.2639	None	gnomAD-4.0.0	1.60804E-06
16654	4	P/T	4	None	0.2639	None	gnomAD-4.0.0	6.43217E-06
16655	5	P/T	5	rs794729449	0.1150	None	gnomAD-4.0.0	6.85852E-07
16656	6	R/C	6	rs1030093239	0.3004	None	gnomAD-2.1.1	7.35E-06
16656	6	R/C	6	rs1030093239	0.3004	None	gnomAD-3.1.2	1.32E-05
16656	6	R/C	6	rs1030093239	0.3004	None	gnomAD-4.0.0	1.11796E-05
16656	6	R/H	6	rs373799076	0.3004	None	gnomAD-2.1.1	3.32E-05
16656	6	R/H	6	rs373799076	0.3004	None	gnomAD-3.1.2	6.61E-06
16656	6	R/H	6	rs373799076	0.3004	None	gnomAD-4.0.0	3.04448E-05
16656	6	R/L	6	rs373799076	0.3004	None	gnomAD-4.0.0	6.17284E-06
16656	6	R/S	6	rs1030093239	0.3004	None	gnomAD-2.1.1	8.3E-06
16656	6	R/S	6	rs1030093239	0.3004	None	gnomAD-4.0.0	5.48543E-06
16659	9	E/K	11	rs778767799	0.4999	None	gnomAD-2.1.1	4.13E-06
16659	9	E/K	11	rs778767799	0.4999	None	gnomAD-3.1.2	6.59E-06
16659	9	E/K	11	rs778767799	0.4999	None	gnomAD-4.0.0	6.4271E-06
16660	10	V/I	12	rs757016105	0.2764	None	gnomAD-2.1.1	3.71E-05
16660	10	V/I	12	rs757016105	0.2764	None	gnomAD-3.1.2	6.59E-06
16660	10	V/I	12	rs757016105	0.2764	None	gnomAD-4.0.0	2.44193E-05
16661	11	I/T	13	None	0.5761	None	gnomAD-4.0.0	1.3702E-06
16661	11	I/V	13	rs1353241870	0.5761	None	gnomAD-2.1.1	4.12E-06
16661	11	I/V	13	rs1353241870	0.5761	None	gnomAD-4.0.0	1.59611E-06
16662	12	N/D	14	rs2056522991	0.5459	None	gnomAD-3.1.2	6.59E-06
16662	12	N/D	14	rs2056522991	0.5459	None	gnomAD-4.0.0	6.58623E-06
16662	12	N/S	14	rs36043230	0.5459	None	gnomAD-2.1.1	4.12E-06
16662	12	N/S	14	rs36043230	0.5459	None	gnomAD-3.1.2	1.32E-05
16662	12	N/S	14	rs36043230	0.5459	None	gnomAD-4.0.0	1.86158E-06
16662	12	N/T	14	rs36043230	0.5459	None	gnomAD-2.1.1	1.57647E-02
16662	12	N/T	14	rs36043230	0.5459	None	gnomAD-3.1.2	1.43738E-02
16662	12	N/T	14	rs36043230	0.5459	None	1000 genomes	6.38978E-03
16662	12	N/T	14	rs36043230	0.5459	None	gnomAD-4.0.0	1.95167E-02
16663	13	I/T	15	rs774556838	0.2062	None	gnomAD-2.1.1	1.23E-05
16663	13	I/T	15	rs774556838	0.2062	None	gnomAD-3.1.2	1.32E-05
16663	13	I/T	15	rs774556838	0.2062	None	gnomAD-4.0.0	1.61339E-05
16663	13	I/V	15	rs1410838349	0.2062	None	gnomAD-4.0.0	3.42538E-06
16664	14	T/I	16	rs1171944721	0.2430	None	gnomAD-2.1.1	8.23E-06
16664	14	T/I	16	rs1171944721	0.2430	None	gnomAD-4.0.0	7.97939E-06
16665	15	K/R	17	None	0.4179	None	gnomAD-4.0.0	1.59558E-06
16668	18	A/E	20	None	0.0900	None	gnomAD-4.0.0	1.59546E-06
16668	18	A/P	20	None	0.0900	None	gnomAD-4.0.0	6.84984E-07
16668	18	A/S	20	None	0.0900	None	gnomAD-4.0.0	6.84984E-07
16668	18	A/V	20	None	0.0900	None	gnomAD-4.0.0	1.59546E-06
16670	20	L/I	22	None	0.1148	None	gnomAD-4.0.0	1.59526E-06
16673	23	T/R	25	rs373889292	0.2583	None	gnomAD-4.0.0	3.42471E-06
16674	24	V/I	26	rs2056518372	0.5320	None	gnomAD-3.1.2	6.58E-06
16674	24	V/I	26	rs2056518372	0.5320	None	gnomAD-4.0.0	5.58331E-06
16676	26	E/G	28	None	0.6130	None	gnomAD-4.0.0	1.59497E-06
16676	26	E/K	28	rs759582108	0.6130	None	gnomAD-2.1.1	4.09E-06
16676	26	E/K	28	rs759582108	0.6130	None	gnomAD-4.0.0	4.78506E-06
16678	28	D/E	30	rs774889204	0.3555	None	gnomAD-2.1.1	4.09E-06
16678	28	D/G	30	None	0.3555	None	gnomAD-4.0.0	1.5948E-06
16680	30	G/R	32	rs1206390929	0.6471	None	gnomAD-2.1.1	4.09E-06
16680	30	G/R	32	rs1206390929	0.6471	None	gnomAD-4.0.0	3.18982E-06
16681	31	S/P	33	None	0.2285	None	gnomAD-4.0.0	1.36975E-06
16681	31	S/T	33	rs771522078	0.2285	None	gnomAD-2.1.1	4.09E-06
16681	31	S/T	33	rs771522078	0.2285	None	gnomAD-4.0.0	6.84876E-07
16682	32	P/L	34	rs1349579168	0.6991	None	gnomAD-2.1.1	4.09E-06
16682	32	P/L	34	rs1349579168	0.6991	None	gnomAD-3.1.2	6.58E-06
16682	32	P/L	34	rs1349579168	0.6991	None	gnomAD-4.0.0	1.24064E-06
16682	32	P/S	34	None	0.6991	None	gnomAD-4.0.0	4.78432E-06
16682	32	P/T	34	rs1231714517	0.6991	None	gnomAD-2.1.1	4.09E-06
16682	32	P/T	34	rs1231714517	0.6991	None	gnomAD-4.0.0	1.59477E-06
16684	34	T/I	36	rs1303563982	0.3939	None	gnomAD-2.1.1	4.08E-06
16684	34	T/I	36	rs1303563982	0.3939	None	gnomAD-4.0.0	1.36963E-06
16684	34	T/N	36	None	0.3939	None	gnomAD-4.0.0	1.36963E-06
16684	34	T/S	36	None	0.3939	None	gnomAD-4.0.0	6.84816E-07
16686	36	Y/C	38	rs2056512518	0.1195	RCM	Literature	None
16687	37	I/M	39	rs1559789920	0.1406	None	gnomAD-2.1.1	4.07E-06
16687	37	I/M	39	rs1559789920	0.1406	None	gnomAD-4.0.0	1.59425E-06
16687	37	I/V	39	rs727504194	0.1406	None	gnomAD-2.1.1	7.33E-05
16687	37	I/V	39	rs727504194	0.1406	None	gnomAD-3.1.2	1.31636E-04
16687	37	I/V	39	rs727504194	0.1406	None	gnomAD-4.0.0	2.72912E-05
16688	38	V/E	40	None	0.1192	None	gnomAD-4.0.0	2.40064E-06
16693	43	V/A	50	rs927020149	0.4701	None	gnomAD-2.1.1	4.06E-06
16693	43	V/A	50	rs927020149	0.4701	None	gnomAD-3.1.2	6.58E-06
16693	43	V/A	50	rs927020149	0.4701	None	gnomAD-4.0.0	5.58201E-06
16693	43	V/I	50	rs377141765	0.4701	None	gnomAD-2.1.1	2.16E-05
16693	43	V/I	50	rs377141765	0.4701	None	gnomAD-3.1.2	3.29E-05
16693	43	V/I	50	rs377141765	0.4701	None	1000 genomes	1.99681E-04
16693	43	V/I	50	rs377141765	0.4701	None	gnomAD-4.0.0	3.53491E-05
16694	44	R/K	54	rs779633258	0.6563	None	gnomAD-2.1.1	4.06E-06
16694	44	R/K	54	rs779633258	0.6563	None	gnomAD-3.1.2	6.58E-06
16694	44	R/K	54	rs779633258	0.6563	None	gnomAD-4.0.0	6.58224E-06
16695	45	R/Q	60	rs794729451	0.6033	None	gnomAD-2.1.1	4.06E-06
16695	45	R/Q	60	rs794729451	0.6033	None	gnomAD-3.1.2	2.63E-05
16695	45	R/Q	60	rs794729451	0.6033	None	gnomAD-4.0.0	1.05435E-05
16696	46	K/N	63	rs745412383	1.1207	None	gnomAD-2.1.1	4.06E-06
16696	46	K/N	63	rs745412383	1.1207	None	gnomAD-4.0.0	1.59406E-06
16697	47	G/A	64	None	0.4083	None	gnomAD-4.0.0	1.59394E-06
16697	47	G/C	64	rs1553698627	0.4083	None	gnomAD-2.1.1	4.05E-06
16697	47	G/C	64	rs1553698627	0.4083	None	gnomAD-4.0.0	2.05408E-06
16697	47	G/S	64	rs1553698627	0.4083	None	gnomAD-2.1.1	1.22E-05
16697	47	G/S	64	rs1553698627	0.4083	None	gnomAD-4.0.0	6.84694E-07
16698	48	W/R	65	None	0.2502	None	gnomAD-4.0.0	1.59388E-06
16699	49	Q/R	66	None	0.4586	None	gnomAD-4.0.0	1.59381E-06
16700	50	T/A	67	None	0.4340	None	gnomAD-4.0.0	2.40064E-06
16701	51	V/M	68	None	0.2826	None	gnomAD-4.0.0	1.5939E-06
16702	52	D/N	69	rs1417347726	0.3157	None	gnomAD-2.1.1	7.19E-06
16702	52	D/N	69	rs1417347726	0.3157	None	gnomAD-3.1.2	6.58E-06
16702	52	D/N	69	rs1417347726	0.3157	None	gnomAD-4.0.0	2.48081E-06
16703	53	T/A	70	rs778518712	0.4463	None	gnomAD-2.1.1	4.05E-06
16703	53	T/A	70	rs778518712	0.4463	None	gnomAD-4.0.0	1.59387E-06
16703	53	T/I	70	rs757138357	0.4463	None	gnomAD-2.1.1	4.05E-06
16703	53	T/I	70	rs757138357	0.4463	None	gnomAD-4.0.0	1.59408E-06
16703	53	T/N	70	rs757138357	0.4463	None	gnomAD-4.0.0	3.18816E-06
16706	56	K/E	83	None	0.8072	None	gnomAD-4.0.0	2.40064E-06
16706	56	K/R	83	rs879111780	0.8072	None	gnomAD-2.1.1	7.18E-06
16706	56	K/R	83	rs879111780	0.8072	None	gnomAD-3.1.2	1.32E-05
16706	56	K/R	83	rs879111780	0.8072	None	gnomAD-4.0.0	6.41578E-06
16707	57	D/N	88	rs1158553720	0.7092	None	gnomAD-2.1.1	3.19E-05
16707	57	D/N	88	rs1158553720	0.7092	None	gnomAD-3.1.2	6.58E-06
16707	57	D/N	88	rs1158553720	0.7092	None	gnomAD-4.0.0	4.34139E-06
16708	58	T/A	89	rs2056500591	0.2225	None	gnomAD-3.1.2	6.58E-06
16708	58	T/A	89	rs2056500591	0.2225	None	gnomAD-4.0.0	2.56635E-06
16708	58	T/N	89	rs777539591	0.2225	None	gnomAD-2.1.1	4.04E-06
16708	58	T/N	89	rs777539591	0.2225	None	gnomAD-4.0.0	1.36939E-06
16708	58	T/P	89	None	0.2225	None	gnomAD-4.0.0	1.59389E-06
16708	58	T/S	89	None	0.2225	None	gnomAD-4.0.0	1.36939E-06
16709	59	K/N	90	rs1244376906	0.6790	None	gnomAD-2.1.1	3.19E-05
16709	59	K/N	90	rs1244376906	0.6790	None	gnomAD-3.1.2	6.58E-06
16709	59	K/N	90	rs1244376906	0.6790	None	gnomAD-4.0.0	6.58328E-06
16709	59	K/Q	90	rs755961446	0.6790	None	gnomAD-2.1.1	1.21E-05
16709	59	K/Q	90	rs755961446	0.6790	None	gnomAD-4.0.0	7.96952E-06
16709	59	K/R	90	rs2056499137	0.6790	None	gnomAD-3.1.2	6.58E-06
16709	59	K/R	90	rs2056499137	0.6790	None	gnomAD-4.0.0	2.56639E-06
16711	61	T/R	92	None	0.4425	None	gnomAD-4.0.0	1.59393E-06
16712	62	V/D	93	None	0.1168	None	gnomAD-4.0.0	6.84701E-07
16712	62	V/G	93	rs1314552701	0.1168	None	gnomAD-2.1.1	4.04E-06
16712	62	V/G	93	rs1314552701	0.1168	None	gnomAD-4.0.0	4.1082E-06
16712	62	V/I	93	None	0.1168	None	gnomAD-4.0.0	6.84696E-07
16712	62	V/L	93	rs2056497488	0.1168	None	gnomAD-4.0.0	6.84696E-07
16713	63	T/I	94	rs2056496324	0.5299	None	gnomAD-3.1.2	6.58E-06
16713	63	T/I	94	rs2056496324	0.5299	None	gnomAD-4.0.0	6.58233E-06
16714	64	P/L	96	rs1309789816	0.6333	None	gnomAD-2.1.1	4.04E-06
16714	64	P/L	96	rs1309789816	0.6333	None	gnomAD-4.0.0	2.05411E-06
16715	65	L/V	97	rs1181230555	0.1204	None	gnomAD-2.1.1	6.38E-05
16715	65	L/V	97	rs1181230555	0.1204	None	gnomAD-3.1.2	1.97E-05
16715	65	L/V	97	rs1181230555	0.1204	None	gnomAD-4.0.0	7.69888E-06
16717	67	E/D	99	rs369623681	0.5657	None	gnomAD-2.1.1	1.08E-05
16717	67	E/D	99	rs369623681	0.5657	None	gnomAD-3.1.2	1.97E-05
16717	67	E/D	99	rs369623681	0.5657	None	gnomAD-4.0.0	2.17067E-05
16718	68	G/V	100	None	0.3761	None	gnomAD-4.0.0	1.59394E-06
16719	69	S/Y	102	rs1416967090	0.1347	None	gnomAD-2.1.1	4.04E-06
16719	69	S/Y	102	rs1416967090	0.1347	None	gnomAD-4.0.0	1.594E-06
16721	71	Y/C	104	None	0.1183	None	gnomAD-4.0.0	1.36945E-06
16724	74	R/Q	107	rs768793035	0.0968	None	gnomAD-2.1.1	7.17E-06
16724	74	R/Q	107	rs768793035	0.0968	None	gnomAD-3.1.2	1.32E-05
16724	74	R/Q	107	rs768793035	0.0968	None	gnomAD-4.0.0	2.3568E-05
16726	76	A/T	109	None	0.0559	None	gnomAD-4.0.0	1.20032E-06
16727	77	A/T	110	rs766576103	0.0835	None	gnomAD-2.1.1	1.21E-05
16727	77	A/T	110	rs766576103	0.0835	None	gnomAD-4.0.0	4.10832E-06
16727	77	A/V	110	None	0.0835	None	gnomAD-4.0.0	1.20032E-06
16730	80	A/T	113	None	0.5543	None	gnomAD-4.0.0	3.42348E-06
16730	80	A/V	113	rs763483590	0.5543	None	gnomAD-2.1.1	4.04E-06
16730	80	A/V	113	rs763483590	0.5543	None	gnomAD-4.0.0	1.59398E-06
16731	81	I/T	114	None	0.6452	None	gnomAD-4.0.0	1.59386E-06
16731	81	I/V	114	None	0.6452	None	gnomAD-4.0.0	1.20032E-06
16732	82	G/R	115	rs1419646565	0.1720	None	gnomAD-2.1.1	4.04E-06
16732	82	G/R	115	rs1419646565	0.1720	None	gnomAD-4.0.0	1.59388E-06
16734	84	S/G	118	rs1227059346	0.0966	None	gnomAD-3.1.2	6.58E-06
16734	84	S/G	118	rs1227059346	0.0966	None	gnomAD-4.0.0	6.5825E-06
16735	85	D/E	119	None	0.8083	None	gnomAD-4.0.0	6.84702E-07
16735	85	D/N	119	rs773927256	0.8083	None	gnomAD-2.1.1	8.07E-06
16735	85	D/N	119	rs773927256	0.8083	None	gnomAD-3.1.2	6.58E-06
16735	85	D/N	119	rs773927256	0.8083	None	gnomAD-4.0.0	1.41157E-05
16736	86	Y/N	120	None	0.2489	None	gnomAD-4.0.0	1.20032E-06
16737	87	T/A	121	None	0.2041	None	gnomAD-4.0.0	1.59394E-06
16737	87	T/I	121	None	0.2041	None	gnomAD-4.0.0	3.60097E-06
16738	88	E/G	122	None	0.3100	None	gnomAD-4.0.0	3.18788E-06
16738	88	E/K	122	rs148018042	0.3100	None	gnomAD-2.1.1	1.46918E-04
16738	88	E/K	122	rs148018042	0.3100	None	gnomAD-3.1.2	1.84232E-04
16738	88	E/K	122	rs148018042	0.3100	None	1000 genomes	3.99361E-04
16738	88	E/K	122	rs148018042	0.3100	None	gnomAD-4.0.0	2.19528E-04
16739	89	I/V	123	rs1553698265	0.1563	None	gnomAD-4.0.0	1.59395E-06
16740	90	E/G	124	rs1314963445	1.0367	None	gnomAD-3.1.2	6.58E-06
16740	90	E/G	124	rs1314963445	1.0367	None	gnomAD-4.0.0	6.57903E-06
16740	90	E/K	124	rs771586396	1.0367	None	gnomAD-2.1.1	4.04E-06
16740	90	E/K	124	rs771586396	1.0367	None	gnomAD-4.0.0	2.05414E-06
16741	91	D/E	125	rs372658275	0.8674	None	gnomAD-3.1.2	1.97E-05
16741	91	D/E	125	rs372658275	0.8674	None	gnomAD-4.0.0	3.10078E-06
16743	93	V/L	127	None	0.2413	None	gnomAD-4.0.0	1.59407E-06
16743	93	V/M	127	None	0.2413	None	gnomAD-4.0.0	1.59407E-06
16745	95	A/T	130	rs2056479723	0.0689	None	gnomAD-3.1.2	6.58E-06
16745	95	A/T	130	rs2056479723	0.0689	None	gnomAD-4.0.0	1.86092E-06
16746	96	K/Q	131	None	0.3891	None	gnomAD-4.0.0	4.80129E-06
16746	96	K/T	131	rs1367329297	0.3891	None	gnomAD-3.1.2	6.58E-06
16746	96	K/T	131	rs1367329297	0.3891	None	gnomAD-4.0.0	2.0302E-06
16747	97	D/G	132	rs745559631	0.5953	None	gnomAD-2.1.1	4.04E-06

Position	Domain position	SAV	RS	Q(SASA)	Source	Structural Position	Disease	AlphaMissense (IC)	AlphaMissense (N2AB)	CADD	Condel	DUET	FATHMM	M-CAP	mCSM	MetaLR	MetaSVM	MPC	MutationAssessor	MutationTaster	MutPred	MVP	PolyPhen-2	PrimateAI	PROVEAN	REVEL	Rhapsody	SIFT	Zygosity	Comments	MAF	AFR	AMR	AMS	ASJ	EAS	EUR	FIN	MDE	NFE	SAS	OTH	Site Annotation	Predicted PPI	mCSM-PPI
16651	1	P/H	None	0.4222	gnomAD-4.0.0	1	None	0.5381	0.6527	29.5	D	None	0.52	0.020663	-0.333	0.4039	-0.1852	0.497233381256	2.86	1.0	0.335	0.522129480193	1.0	0.7383928895	-6.57	0.4	0.861	0.018	None	None	6.89576E-07	0	0	0	0	None	0	0	6.89576E-07	0	1.20514E-05	0	None	I	None
16651	1	P/S	rs537759268	0.4222	gnomAD-3.1.2	1	None	0.3866	0.4781	32.0	N	None	0.57	0.023678	-0.522	0.364	-0.3326	0.464868906428	2.31	1.0	0.367	0.283761946502	1.0	0.699605703354	-5.77	0.384	0.816	0.056	None	None	6.65E-06	0	0	0	0	None	0	0	6.65E-06	1.47E-05	0	0	None	I	None
16651	1	P/S	rs537759268	0.4222	gnomAD-4.0.0	1	None	0.3866	0.4781	32.0	N	None	0.57	0.023678	-0.522	0.364	-0.3326	0.464868906428	2.31	1.0	0.367	0.283761946502	1.0	0.699605703354	-5.77	0.384	0.816	0.056	None	None	2.50083E-06	0	0	0	0	None	0	0	2.50083E-06	3.40097E-06	0	0	None	I	None
16651	1	P/T	rs537759268	0.4222	gnomAD-2.1.1	1	None	0.325	0.3565	31.0	N	-0.503	0.58	0.022186	-0.529	0.2988	-0.5152	0.487905608832	2.31	1.0	0.315	0.367042808489	1.0	0.725789427757	-5.6	0.313	0.805	0.196	None	None	4.36E-06	0	3.19E-05	0	0	None	0	None	4.36E-06	0	0	0	None	I	None
16651	1	P/T	rs537759268	0.4222	1000 genomes	1	None	0.325	0.3565	31.0	N	-0.503	0.58	0.022186	-0.529	0.2988	-0.5152	0.487905608832	2.31	1.0	0.315	0.367042808489	1.0	0.725789427757	-5.6	0.313	0.805	0.196	None	None	1.99681E-04	0	1.4E-03	None	0	0	None	None	1.99681E-04	None	0	None	None	I	None
16653	3	S/L	rs746669146	0.1898	gnomAD-2.1.1	3	None	0.2606	0.2669	32.0	D	0.305	0.13	0.073668	0.171	0.5033	0.2077	0.333351661895	3.395	0.999989	0.46	0.689839040572	0.989	0.614840388298	-4.73	0.567	0.764	0.022	None	None	8.44E-06	0	0	0	0	None	7.07E-05	None	8.44E-06	0	0	0	None	N	None
16653	3	S/L	rs746669146	0.1898	gnomAD-4.0.0	3	None	0.2606	0.2669	32.0	D	0.305	0.13	0.073668	0.171	0.5033	0.2077	0.333351661895	3.395	0.999989	0.46	0.689839040572	0.989	0.614840388298	-4.73	0.567	0.764	0.022	None	None	4.82916E-06	0	0	0	0	None	0	0	4.82916E-06	0	4.43262E-05	0	None	N	None
16654	4	P/A	rs1362265469	0.2639	gnomAD-2.1.1	4	None	0.1191	0.117	22.8	N	-1.498	0.62	0.018253	-1.498	0.1025	-1.0236	0.0879090038759	0.99	0.999905	0.487	0.130388298395	0.025	0.679098010063	-5.07	0.174	0.429	1.0	None	None	4.21E-06	0	3E-05	0	0	None	0	None	4.21E-06	0	0	0	None	N	None
16654	4	P/A	rs1362265469	0.2639	gnomAD-4.0.0	4	None	0.1191	0.117	22.8	N	-1.498	0.62	0.018253	-1.498	0.1025	-1.0236	0.0879090038759	0.99	0.999905	0.487	0.130388298395	0.025	0.679098010063	-5.07	0.174	0.429	1.0	None	None	1.60804E-06	0	2.34313E-05	0	0	None	0	0	1.60804E-06	0	0	0	None	N	None
16654	4	P/S	rs1362265469	0.2639	gnomAD-2.1.1	4	None	0.2936	0.3395	23.2	D	-1.598	0.32	0.05267	-1.468	0.2714	-0.4419	0.199523481285	2.545	0.999942	0.461	0.208816687407	0.698	0.681109130383	-5.33	0.298	0.765	0.457	None	None	4.21E-06	0	0	0	0	None	0	None	4.21E-06	0	9.38E-06	0	None	N	None
16654	4	P/S	rs1362265469	0.2639	gnomAD-4.0.0	4	None	0.2936	0.3395	23.2	D	-1.598	0.32	0.05267	-1.468	0.2714	-0.4419	0.199523481285	2.545	0.999942	0.461	0.208816687407	0.698	0.681109130383	-5.33	0.298	0.765	0.457	None	None	1.60804E-06	0	0	0	0	None	0	0	1.60804E-06	2.87247E-06	0	0	None	N	None
16654	4	P/T	None	0.2639	gnomAD-4.0.0	4	None	0.4403	0.5139	22.9	D	None	0.26	0.048386	-1.413	0.2782	-0.5359	0.100773543155	3.26	0.999937	0.455	0.285316908763	0.032	0.708079814911	-5.3	0.286	0.517	0.182	None	None	6.43217E-06	0	0	0	1.11882E-04	None	0	0	6.43217E-06	0	0	0	None	N	None
16655	5	P/T	rs794729449	0.1150	gnomAD-4.0.0	5	None	0.9815	0.9884	26.0	D	None	-0.64	0.057873	-2.476	0.6868	0.603	0.48919594472	3.75	1.0	0.722	0.760836599884	1.0	0.806904792786	-6.1	0.783	0.869	0.115	None	None	6.85852E-07	0	0	0	2.5391E-05	None	0	0	6.85852E-07	0	0	0	None	N	None
16656	6	R/C	rs1030093239	0.3004	gnomAD-2.1.1	6	None	0.4269	0.5644	24.9	D	-0.258	0.29	0.048552	-0.693	0.2363	-0.6083	0.134675723208	2.505	1.0	0.47	0.514866526686	0.252	0.800137460232	-5.87	0.268	0.517	0.002	None	None	7.35E-06	4.21E-05	0	0	0	None	0	None	7.35E-06	0	8.13E-06	0	None	N	None
16656	6	R/C	rs1030093239	0.3004	gnomAD-3.1.2	6	None	0.4269	0.5644	24.9	D	-0.258	0.29	0.048552	-0.693	0.2363	-0.6083	0.134675723208	2.505	1.0	0.47	0.514866526686	0.252	0.800137460232	-5.87	0.268	0.517	0.002	None	None	1.32E-05	0	0	0	0	None	0	0	1.32E-05	1.47E-05	2.0816E-04	0	None	N	None
16656	6	R/C	rs1030093239	0.3004	gnomAD-4.0.0	6	None	0.4269	0.5644	24.9	D	-0.258	0.29	0.048552	-0.693	0.2363	-0.6083	0.134675723208	2.505	1.0	0.47	0.514866526686	0.252	0.800137460232	-5.87	0.268	0.517	0.002	None	None	1.11796E-05	1.33976E-05	0	0	0	None	0	0	1.11796E-05	1.01805E-05	4.42165E-05	1.60539E-05	None	N	None
16656	6	R/H	rs373799076	0.3004	gnomAD-2.1.1	6	None	0.2806	0.3524	None	D	-1.201	None	None	-1.601	None	None	None	None	None	None	None	1.0	None	None	0.382	0.647	None	None	None	3.32E-05	0	2.95E-05	0	2.85812E-04	None	0	None	3.32E-05	0	1.86E-05	0	None	N	None
16656	6	R/H	rs373799076	0.3004	gnomAD-3.1.2	6	None	0.2806	0.3524	None	D	-1.201	None	None	-1.601	None	None	None	None	None	None	None	1.0	None	None	0.382	0.647	None	None	None	6.61E-06	2.43E-05	0	0	0	None	0	0	6.61E-06	0	0	0	None	N	None
16656	6	R/H	rs373799076	0.3004	gnomAD-4.0.0	6	None	0.2806	0.3524	None	D	-1.201	None	None	-1.601	None	None	None	None	None	None	None	1.0	None	None	0.382	0.647	None	None	None	3.04448E-05	2.68039E-05	3.35762E-05	0	4.49762E-05	None	0	0	3.04448E-05	3.47887E-05	1.10735E-05	1.60498E-05	None	N	None
16656	6	R/L	rs373799076	0.3004	gnomAD-4.0.0	6	None	0.5086	0.6977	29.7	N	None	0.34	0.041955	0.164	0.2341	-0.6613	0.332033585777	1.235	1.0	0.46	0.552656131934	0.913	0.762902081013	-5.27	0.306	0.707	0.089	None	None	6.17284E-06	0	0	0	0	None	0	0	6.17284E-06	8.10304E-06	0	0	None	N	None
16656	6	R/S	rs1030093239	0.3004	gnomAD-2.1.1	6	None	0.7893	0.8815	26.1	N	-0.465	0.44	0.029262	-1.149	0.2143	-0.675	0.376133211831	0.87	0.999959	0.455	0.394536629495	0.954	0.74964684248	-4.33	0.332	0.719	0.017	None	None	8.3E-06	0	0	0	0	None	6.71E-05	None	8.3E-06	0	0	0	None	N	None
16656	6	R/S	rs1030093239	0.3004	gnomAD-4.0.0	6	None	0.7893	0.8815	26.1	N	-0.465	0.44	0.029262	-1.149	0.2143	-0.675	0.376133211831	0.87	0.999959	0.455	0.394536629495	0.954	0.74964684248	-4.33	0.332	0.719	0.017	None	None	5.48543E-06	0	0	0	0	None	0	0	5.48543E-06	1.80046E-06	5.83703E-05	1.66091E-05	None	N	None
16659	9	E/K	rs778767799	0.4999	gnomAD-2.1.1	11	None	0.6271	0.7992	24.1	N	0.158	0.54	0.078397	-0.158	0.1661	-0.7253	0.34802745607	0.975	0.99986	0.594	0.250039746154	0.98	0.679932296276	-2.33	0.301	0.551	0.202	None	None	4.13E-06	0	0	0	0	None	0	None	4.13E-06	0	9.25E-06	0	None	N	None
16659	9	E/K	rs778767799	0.4999	gnomAD-3.1.2	11	None	0.6271	0.7992	24.1	N	0.158	0.54	0.078397	-0.158	0.1661	-0.7253	0.34802745607	0.975	0.99986	0.594	0.250039746154	0.98	0.679932296276	-2.33	0.301	0.551	0.202	None	None	6.59E-06	0	0	0	0	None	9.45E-05	0	6.59E-06	0	0	0	None	N	None
16659	9	E/K	rs778767799	0.4999	gnomAD-4.0.0	11	None	0.6271	0.7992	24.1	N	0.158	0.54	0.078397	-0.158	0.1661	-0.7253	0.34802745607	0.975	0.99986	0.594	0.250039746154	0.98	0.679932296276	-2.33	0.301	0.551	0.202	None	None	6.4271E-06	0	0	0	0	None	1.58519E-05	0	6.4271E-06	9.59168E-06	0	0	None	N	None
16660	10	V/I	rs757016105	0.2764	gnomAD-2.1.1	12	None	0.1374	0.1398	26.2	N	-0.438	0.26	0.012035	-0.532	0.3755	-0.3207	0.420894402933	1.04	1.0	0.508	0.630051231342	0.997	0.583780646324	-0.7	0.235	0.577	0.631	None	None	3.71E-05	0	2.34206E-04	0	0	None	0	None	3.71E-05	0	0	1.69722E-04	None	N	None
16660	10	V/I	rs757016105	0.2764	gnomAD-3.1.2	12	None	0.1374	0.1398	26.2	N	-0.438	0.26	0.012035	-0.532	0.3755	-0.3207	0.420894402933	1.04	1.0	0.508	0.630051231342	0.997	0.583780646324	-0.7	0.235	0.577	0.631	None	None	6.59E-06	0	6.57E-05	0	0	None	0	0	6.59E-06	0	0	0	None	N	None
16660	10	V/I	rs757016105	0.2764	gnomAD-4.0.0	12	None	0.1374	0.1398	26.2	N	-0.438	0.26	0.012035	-0.532	0.3755	-0.3207	0.420894402933	1.04	1.0	0.508	0.630051231342	0.997	0.583780646324	-0.7	0.235	0.577	0.631	None	None	2.44193E-05	0	3.06018E-04	0	0	None	0	0	2.44193E-05	0	0	2.85339E-05	None	N	None
16661	11	I/T	None	0.5761	gnomAD-4.0.0	13	None	0.2618	0.3099	28.9	N	None	0.56	0.043168	-0.81	0.1147	-0.7163	0.340369497506	-0.19	0.999594	0.471	0.586144602217	0.961	0.788802266121	-2.83	0.311	0.467	0.301	None	None	1.3702E-06	0	0	3.83083E-05	0	None	0	0	1.3702E-06	0	0	1.65942E-05	None	N	None
16661	11	I/V	rs1353241870	0.5761	gnomAD-2.1.1	13	None	0.1028	0.1028	22.0	N	-0.255	0.44	0.019006	-0.652	0.0724	-0.9717	0.0759569308348	-0.16	0.921512	0.406	0.523961927912	0.044	0.640820741653	-0.37	0.103	0.107	0.735	None	None	4.12E-06	0	0	0	0	None	3.29E-05	None	4.12E-06	0	0	0	None	N	None
16661	11	I/V	rs1353241870	0.5761	gnomAD-4.0.0	13	None	0.1028	0.1028	22.0	N	-0.255	0.44	0.019006	-0.652	0.0724	-0.9717	0.0759569308348	-0.16	0.921512	0.406	0.523961927912	0.044	0.640820741653	-0.37	0.103	0.107	0.735	None	None	1.59611E-06	0	0	0	0	None	0	0	1.59611E-06	0	1.43521E-05	0	None	N	None
16662	12	N/D	rs2056522991	0.5459	gnomAD-3.1.2	14	None	0.3605	0.4113	24.6	N	None	0.44	0.053114	0.192	0.1335	-0.6566	0.400827180659	-0.185	0.992286	0.483	0.181679512989	0.978	0.695693492889	-3.47	0.357	0.471	0.507	None	None	6.59E-06	0	6.56E-05	0	0	None	0	0	6.59E-06	0	0	0	None	N	None
16662	12	N/D	rs2056522991	0.5459	gnomAD-4.0.0	14	None	0.3605	0.4113	24.6	N	None	0.44	0.053114	0.192	0.1335	-0.6566	0.400827180659	-0.185	0.992286	0.483	0.181679512989	0.978	0.695693492889	-3.47	0.357	0.471	0.507	None	None	6.58623E-06	0	6.56254E-05	0	0	None	0	0	6.58623E-06	0	0	0	None	N	None
16662	12	N/S	rs36043230	0.5459	gnomAD-2.1.1	14	None	0.1114	0.0943	23.7	N	0.074	0.42	0.019003	-0.173	0.1094	-0.9059	0.109384678419	0.49	0.982493	0.493	0.128392430309	0.63	0.584691762924	-3.17	0.133	0.166	0.39	None	None	4.12E-06	6.61E-05	0	0	0	None	0	None	4.12E-06	0	0	0	None	N	None
16662	12	N/S	rs36043230	0.5459	gnomAD-3.1.2	14	None	0.1114	0.0943	23.7	N	0.074	0.42	0.019003	-0.173	0.1094	-0.9059	0.109384678419	0.49	0.982493	0.493	0.128392430309	0.63	0.584691762924	-3.17	0.133	0.166	0.39	None	None	1.32E-05	2.42E-05	6.56E-05	0	0	None	0	0	1.32E-05	0	0	0	None	N	None
16662	12	N/S	rs36043230	0.5459	gnomAD-4.0.0	14	None	0.1114	0.0943	23.7	N	0.074	0.42	0.019003	-0.173	0.1094	-0.9059	0.109384678419	0.49	0.982493	0.493	0.128392430309	0.63	0.584691762924	-3.17	0.133	0.166	0.39	None	None	1.86158E-06	2.67373E-05	1.67107E-05	0	0	None	0	0	1.86158E-06	0	0	0	None	N	None
16662	12	N/T	rs36043230	0.5459	gnomAD-2.1.1	14	None	0.2553	0.2119	None	N	0.272	None	None	-0.047	None	None	None	None	None	None	None	0.956	None	None	0.328	0.465	None	None	None	1.57647E-02	2.89551E-03	9.19212E-03	5.50089E-02	5.24E-05	None	7.7652E-03	None	1.57647E-02	1.42456E-02	2.1363E-02	1.94675E-02	None	N	None
16662	12	N/T	rs36043230	0.5459	gnomAD-3.1.2	14	None	0.2553	0.2119	None	N	0.272	None	None	-0.047	None	None	None	None	None	None	None	0.956	None	None	0.328	0.465	None	None	None	1.43738E-02	3.62336E-03	1.10265E-02	5.33449E-02	0	None	1.39754E-02	2.8481E-02	1.43738E-02	2.12475E-02	6.42354E-03	2.15517E-02	None	N	None
16662	12	N/T	rs36043230	0.5459	1000 genomes	14	None	0.2553	0.2119	None	N	0.272	None	None	-0.047	None	None	None	None	None	None	None	0.956	None	None	0.328	0.465	None	None	None	6.38978E-03	2.3E-03	8.6E-03	None	0	1.69E-02	None	None	6.38978E-03	None	6.1E-03	None	None	N	None
16662	12	N/T	rs36043230	0.5459	gnomAD-4.0.0	14	None	0.2553	0.2119	None	N	0.272	None	None	-0.047	None	None	None	None	None	None	None	0.956	None	None	0.328	0.465	None	None	None	1.95167E-02	3.33672E-03	1.0441E-02	5.31584E-02	2.24578E-05	None	1.42754E-02	3.25728E-02	1.95167E-02	2.1871E-02	8.08048E-03	2.20954E-02	None	N	None
16663	13	I/T	rs774556838	0.2062	gnomAD-2.1.1	15	None	0.8041	0.6934	28.5	N	-1.296	0.31	0.02288	-1.631	0.2396	-0.6001	0.327212330022	1.8	0.999993	0.557	0.626729916089	0.925	0.825141727924	-2.67	0.322	0.469	0.224	None	None	1.23E-05	0	0	0	0	None	0	None	1.23E-05	0	2.76E-05	0	None	N	None
16663	13	I/T	rs774556838	0.2062	gnomAD-3.1.2	15	None	0.8041	0.6934	28.5	N	-1.296	0.31	0.02288	-1.631	0.2396	-0.6001	0.327212330022	1.8	0.999993	0.557	0.626729916089	0.925	0.825141727924	-2.67	0.322	0.469	0.224	None	None	1.32E-05	0	0	0	0	None	0	0	1.32E-05	2.95E-05	0	0	None	N	None
16663	13	I/T	rs774556838	0.2062	gnomAD-4.0.0	15	None	0.8041	0.6934	28.5	N	-1.296	0.31	0.02288	-1.631	0.2396	-0.6001	0.327212330022	1.8	0.999993	0.557	0.626729916089	0.925	0.825141727924	-2.67	0.322	0.469	0.224	None	None	1.61339E-05	0	0	0	0	None	0	0	1.61339E-05	2.2052E-05	0	0	None	N	None
16663	13	I/V	rs1410838349	0.2062	gnomAD-4.0.0	15	None	0.1702	0.1393	23.5	N	None	0.48	0.015536	-1.187	0.1129	-0.8277	0.237689050953	-0.075	0.999983	0.396	0.494031935134	0.954	0.691266953945	-0.57	0.185	0.365	0.658	None	None	3.42538E-06	0	0	0	0	None	0	0	3.42538E-06	4.49995E-06	0	0	None	N	None
16664	14	T/I	rs1171944721	0.2430	gnomAD-2.1.1	16	None	0.7581	0.7788	26.8	D	-0.024	0.15	0.055001	0.093	0.4435	-0.048	0.434094922335	2.42	0.999732	0.567	0.564429724435	0.994	0.770478725433	-4.57	0.441	0.431	0.093	None	None	8.23E-06	0	0	0	0	None	0	None	8.23E-06	0	9.21E-06	1.69434E-04	None	N	None
16664	14	T/I	rs1171944721	0.2430	gnomAD-4.0.0	16	None	0.7581	0.7788	26.8	D	-0.024	0.15	0.055001	0.093	0.4435	-0.048	0.434094922335	2.42	0.999732	0.567	0.564429724435	0.994	0.770478725433	-4.57	0.441	0.431	0.093	None	None	7.97939E-06	0	0	0	2.79455E-05	None	0	2.41896E-04	7.97939E-06	5.72692E-06	1.43476E-05	0	None	N	None
16665	15	K/R	None	0.4179	gnomAD-4.0.0	17	None	0.1045	0.1028	24.1	N	None	0.41	0.015388	-0.251	0.1125	-0.9904	0.0777633554608	0.6	0.999759	0.442	0.18274738541	0.031	0.632893979549	-1.83	0.113	0.099	0.373	None	None	1.59558E-06	5.67537E-05	0	0	0	None	0	0	1.59558E-06	0	0	0	None	N	None
16668	18	A/E	None	0.0900	gnomAD-4.0.0	20	None	0.9924	0.9971	27.9	D	None	0.3	0.029512	-2.131	0.4709	0.003	0.499295131401	3.34	1.0	0.68	0.533759884177	1.0	0.742388963699	-3.83	0.512	0.845	0.13	None	None	1.59546E-06	0	0	0	0	None	0	0	1.59546E-06	2.8629E-06	0	0	None	N	None
16668	18	A/P	None	0.0900	gnomAD-4.0.0	20	None	0.9957	0.9982	25.2	D	None	0.3	0.021592	-0.322	0.5025	0.1299	0.525708811115	3.34	1.0	0.712	0.365892764245	1.0	0.742120802402	-3.77	0.571	0.861	0.087	None	None	6.84984E-07	0	0	0	0	None	0	0	6.84984E-07	8.99939E-07	0	0	None	N	None
16668	18	A/S	None	0.0900	gnomAD-4.0.0	20	None	0.5114	0.5922	24.5	D	None	0.31	0.018414	-2.129	0.4086	-0.223	0.44573178934	2.79	1.0	0.586	0.232513804876	1.0	0.661434173584	-2.27	0.346	0.651	0.179	None	None	6.84984E-07	0	0	0	0	None	0	0	6.84984E-07	8.99939E-07	0	0	None	N	None
16668	18	A/V	None	0.0900	gnomAD-4.0.0	20	None	0.3926	0.4989	28.2	N	None	0.58	0.038424	-0.322	0.1663	-0.4883	0.462690307121	0.305	1.0	0.437	0.27855597813	1.0	0.708656549454	-2.87	0.342	0.702	0.301	None	None	1.59546E-06	0	0	0	0	None	0	0	1.59546E-06	2.8629E-06	0	0	None	N	None
16670	20	L/I	None	0.1148	gnomAD-4.0.0	22	None	0.2221	0.2494	24.3	N	None	0.11	0.019794	-0.844	0.3644	-0.2639	0.481209393752	2.255	0.999934	0.556	0.307332253619	0.999	0.799597084522	-1.67	0.312	0.556	0.285	None	None	1.59526E-06	0	0	0	0	None	0	0	1.59526E-06	0	1.4339E-05	0	None	N	None
16673	23	T/R	rs373889292	0.2583	gnomAD-4.0.0	25	None	0.4107	0.7762	None	N	None	None	None	-0.775	None	None	None	None	None	None	None	1.0	None	None	0.484	0.819	None	None	None	3.42471E-06	0	0	0	0	None	0	0	3.42471E-06	4.49959E-06	0	0	None	N	None
16674	24	V/I	rs2056518372	0.5320	gnomAD-3.1.2	26	None	0.0845	0.0804	23.4	N	None	0.44	0.04203	-0.65	0.1692	-0.7337	0.111525478306	1.285	0.708266	0.547	0.37568098594	0.454	0.488305747509	-0.8	0.141	0.457	0.357	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
16674	24	V/I	rs2056518372	0.5320	gnomAD-4.0.0	26	None	0.0845	0.0804	23.4	N	None	0.44	0.04203	-0.65	0.1692	-0.7337	0.111525478306	1.285	0.708266	0.547	0.37568098594	0.454	0.488305747509	-0.8	0.141	0.457	0.357	None	None	5.58331E-06	0	0	0	0	None	0	0	5.58331E-06	7.63272E-06	0	0	None	N	None
16676	26	E/G	None	0.6130	gnomAD-4.0.0	28	None	0.3854	0.5637	29.5	N	None	0.31	0.022037	-0.335	0.3011	-0.449	0.500420847697	0.97	0.999999	0.464	0.460438652622	1.0	0.721532344818	-4.53	0.469	0.647	0.113	None	None	1.59497E-06	0	0	0	0	None	0	0	1.59497E-06	2.86251E-06	0	0	None	I	None
16676	26	E/K	rs759582108	0.6130	gnomAD-2.1.1	28	None	0.4735	0.6819	25.1	N	0.665	0.45	0.016476	0.363	0.2988	-0.5152	0.489131336793	1.19	1.0	0.619	0.383921772103	0.999	0.819964587688	-2.73	0.322	0.667	0.237	None	None	4.09E-06	0	0	0	0	None	3.28E-05	None	4.09E-06	0	0	0	None	I	None
16676	26	E/K	rs759582108	0.6130	gnomAD-4.0.0	28	None	0.4735	0.6819	25.1	N	0.665	0.45	0.016476	0.363	0.2988	-0.5152	0.489131336793	1.19	1.0	0.619	0.383921772103	0.999	0.819964587688	-2.73	0.322	0.667	0.237	None	None	4.78506E-06	0	0	0	0	None	0	0	4.78506E-06	0	4.30182E-05	0	None	I	None
16678	28	D/E	rs774889204	0.3555	gnomAD-2.1.1	30	None	0.7095	0.8199	24.0	D	-0.658	0.37	0.010291	-0.558	0.3327	-0.4416	0.450463449177	2.835	0.999352	0.49	0.291694819147	1.0	0.716671347618	-3.17	0.334	0.451	0.057	None	None	4.09E-06	0	0	0	5.69E-05	None	0	None	4.09E-06	0	0	0	None	I	None
16678	28	D/G	None	0.3555	gnomAD-4.0.0	30	None	0.6946	0.8709	29.8	D	None	0.27	0.019238	-0.765	0.4897	0.1783	0.528847580626	2.98	1.0	0.52	0.443797312901	1.0	0.697149574757	-5.6	0.563	0.717	0.369	None	None	1.5948E-06	0	0	0	0	None	0	0	1.5948E-06	2.86252E-06	0	0	None	I	None
16680	30	G/R	rs1206390929	0.6471	gnomAD-2.1.1	32	None	0.8834	0.956	25.4	D	-0.186	-0.14	0.050018	-0.137	0.5493	0.23	0.506463245118	2.935	1.0	0.601	0.733247199439	1.0	0.730814278126	-6.43	0.686	0.801	0.007	None	None	4.09E-06	0	0	0	0	None	3.28E-05	None	4.09E-06	0	0	0	None	I	None
16680	30	G/R	rs1206390929	0.6471	gnomAD-4.0.0	32	None	0.8834	0.956	25.4	D	-0.186	-0.14	0.050018	-0.137	0.5493	0.23	0.506463245118	2.935	1.0	0.601	0.733247199439	1.0	0.730814278126	-6.43	0.686	0.801	0.007	None	None	3.18982E-06	0	0	0	0	None	0	0	3.18982E-06	0	2.8673E-05	0	None	I	None
16681	31	S/P	None	0.2285	gnomAD-4.0.0	33	None	0.99	0.996	25.8	D	None	0.26	0.033065	-0.27	0.5423	0.3887	0.519256098012	4.085	0.999999	0.562	0.435479573448	1.0	0.71377658844	-3.63	0.553	0.762	0.051	None	None	1.36975E-06	0	0	0	0	None	0	0	1.36975E-06	1.79984E-06	0	0	None	I	None
16681	31	S/T	rs771522078	0.2285	gnomAD-2.1.1	33	None	0.376	0.4827	24.6	N	-0.524	0.31	0.019599	-0.498	0.3734	-0.2573	0.444156248343	2.325	0.999993	0.406	0.245660935333	0.999	0.709059596062	-2.17	0.219	0.589	0.214	None	None	4.09E-06	0	0	0	0	None	0	None	4.09E-06	0	9.12E-06	0	None	I	None
16681	31	S/T	rs771522078	0.2285	gnomAD-4.0.0	33	None	0.376	0.4827	24.6	N	-0.524	0.31	0.019599	-0.498	0.3734	-0.2573	0.444156248343	2.325	0.999993	0.406	0.245660935333	0.999	0.709059596062	-2.17	0.219	0.589	0.214	None	None	6.84876E-07	0	0	0	0	None	0	0	6.84876E-07	8.99922E-07	0	0	None	I	None
16682	32	P/L	rs1349579168	0.6991	gnomAD-2.1.1	34	None	0.2451	0.3022	33.0	D	0.006	0.21	0.03135	-0.2	0.4833	0.0977	0.410852780124	2.94	1.0	0.632	0.717612795731	0.997	0.799634575844	-7.43	0.502	0.636	0.007	None	None	4.09E-06	0	0	0	5.69E-05	None	0	None	4.09E-06	0	0	0	None	I	None
16682	32	P/L	rs1349579168	0.6991	gnomAD-3.1.2	34	None	0.2451	0.3022	33.0	D	0.006	0.21	0.03135	-0.2	0.4833	0.0977	0.410852780124	2.94	1.0	0.632	0.717612795731	0.997	0.799634575844	-7.43	0.502	0.636	0.007	None	None	6.58E-06	0	0	0	1.94856E-04	None	0	0	6.58E-06	0	0	0	None	I	None
16682	32	P/L	rs1349579168	0.6991	gnomAD-4.0.0	34	None	0.2451	0.3022	33.0	D	0.006	0.21	0.03135	-0.2	0.4833	0.0977	0.410852780124	2.94	1.0	0.632	0.717612795731	0.997	0.799634575844	-7.43	0.502	0.636	0.007	None	None	1.24064E-06	0	0	0	2.24467E-05	None	0	0	1.24064E-06	0	1.09856E-05	0	None	I	None
16682	32	P/S	None	0.6991	gnomAD-4.0.0	34	None	0.2524	0.3168	24.8	D	None	0.29	0.030591	-0.247	0.4116	-0.1522	0.354754821167	2.16	0.999961	0.65	0.298056030225	0.978	0.741748690605	-5.9	0.41	0.581	0.009	None	None	4.78432E-06	0	0	0	0	None	0	0	4.78432E-06	8.58797E-06	0	0	None	I	None
16682	32	P/T	rs1231714517	0.6991	gnomAD-2.1.1	34	None	0.2061	0.2607	24.6	D	-0.033	0.28	0.026999	-0.28	0.4342	-0.1063	0.44485578323	2.11	0.999959	0.637	0.461759001683	0.997	0.765567541122	-5.93	0.427	0.573	0.008	None	None	4.09E-06	0	0	0	0	None	0	None	4.09E-06	0	9.11E-06	0	None	I	None
16682	32	P/T	rs1231714517	0.6991	gnomAD-4.0.0	34	None	0.2061	0.2607	24.6	D	-0.033	0.28	0.026999	-0.28	0.4342	-0.1063	0.44485578323	2.11	0.999959	0.637	0.461759001683	0.997	0.765567541122	-5.93	0.427	0.573	0.008	None	None	1.59477E-06	0	0	0	0	None	0	0	1.59477E-06	2.86266E-06	0	0	None	I	None
16684	34	T/I	rs1303563982	0.3939	gnomAD-2.1.1	36	None	0.5223	0.5687	28.8	N	-0.092	0.25	0.027899	-0.158	0.3686	-0.3409	0.480749730577	1.57	1.0	0.508	0.490489133298	1.0	0.882141232491	-4.73	0.481	0.825	0.436	None	None	4.08E-06	0	0	0	0	None	0	None	4.08E-06	0	9.09E-06	0	None	I	None
16684	34	T/I	rs1303563982	0.3939	gnomAD-4.0.0	36	None	0.5223	0.5687	28.8	N	-0.092	0.25	0.027899	-0.158	0.3686	-0.3409	0.480749730577	1.57	1.0	0.508	0.490489133298	1.0	0.882141232491	-4.73	0.481	0.825	0.436	None	None	1.36963E-06	0	0	0	0	None	0	0	1.36963E-06	1.79975E-06	0	0	None	I	None
16684	34	T/N	None	0.3939	gnomAD-4.0.0	36	None	0.4589	0.4723	27.8	D	None	0.25	0.021979	-0.568	0.4709	0.003	0.494608543549	2.7	1.0	0.52	0.499535901811	1.0	0.866360545158	-3.83	0.499	0.769	0.052	None	None	1.36963E-06	0	4.48109E-05	0	0	None	0	0	1.36963E-06	0	0	0	None	I	None
16684	34	T/S	None	0.3939	gnomAD-4.0.0	36	None	0.3266	0.3126	27.6	D	None	0.31	0.023368	-0.777	0.4086	-0.223	0.441239122942	1.38	0.999997	0.54	0.27132560031	0.999	0.833438754082	-3.03	0.475	0.566	0.105	None	None	6.84816E-07	0	0	0	0	None	0	0	6.84816E-07	8.99873E-07	0	0	None	I	None
16686	36	Y/C	rs2056512518	0.1195	http://www.ncbi.nlm.nih.gov/pubmed/24315344;	38	RCM;	0.9745	0.9853	32.0	D	-2.208	-1.48	0.511107	-2.147	0.8252	0.9743	0.517459491388	4.02	1.0	0.82	0.897505141811	1.0	0.87717372179	-7.13	0.962	0.887	0.002	het	Segregation analysis in single RCM family, co-segregates with phenotype (n = 5, 5 affected (total 13))	None	None	None	None	None	None	None	None	None	None	None	None	None	N	None
16687	37	I/M	rs1559789920	0.1406	gnomAD-2.1.1	39	None	0.3203	0.3748	22.6	D	None	0.4	0.013076	-1.514	0.302	-0.1102	0.378943704071	1.82	0.71963	0.449	0.163833314356	0.97	0.658549904823	-2.3	0.42	0.679	0.011	None	None	4.07E-06	0	0	0	5.67E-05	None	0	None	4.07E-06	0	0	0	None	N	None
16687	37	I/M	rs1559789920	0.1406	gnomAD-4.0.0	39	None	0.3203	0.3748	22.6	D	None	0.4	0.013076	-1.514	0.302	-0.1102	0.378943704071	1.82	0.71963	0.449	0.163833314356	0.97	0.658549904823	-2.3	0.42	0.679	0.011	None	None	1.59425E-06	0	0	0	2.79298E-05	None	0	0	1.59425E-06	0	0	0	None	N	None
16687	37	I/V	rs727504194	0.1406	gnomAD-2.1.1	39	None	0.0956	0.1047	23.0	N	-1.662	0.46	0.01061	-1.931	0.0952	-1.0386	0.0752526508292	-0.425	0.995186	0.334	0.447311733946	0.025	0.613167524338	-0.57	0.058	0.299	0.307	None	None	7.33E-05	0	4.95165E-04	0	0	None	0	None	7.33E-05	0	0	1.67898E-04	None	N	None
16687	37	I/V	rs727504194	0.1406	gnomAD-3.1.2	39	None	0.0956	0.1047	23.0	N	-1.662	0.46	0.01061	-1.931	0.0952	-1.0386	0.0752526508292	-0.425	0.995186	0.334	0.447311733946	0.025	0.613167524338	-0.57	0.058	0.299	0.307	None	None	1.31636E-04	0	1.31113E-03	0	0	None	0	0	1.31636E-04	0	0	0	None	N	None
16687	37	I/V	rs727504194	0.1406	gnomAD-4.0.0	39	None	0.0956	0.1047	23.0	N	-1.662	0.46	0.01061	-1.931	0.0952	-1.0386	0.0752526508292	-0.425	0.995186	0.334	0.447311733946	0.025	0.613167524338	-0.57	0.058	0.299	0.307	None	None	2.72912E-05	0	7.18007E-04	0	0	None	0	0	2.72912E-05	0	0	1.60344E-05	None	N	None
16688	38	V/E	None	0.1192	gnomAD-4.0.0	40	None	0.9966	0.9987	29.1	D	None	-0.37	0.147181	-3.387	0.6526	0.6333	0.588389549794	4.075	1.0	0.723	0.891958202521	1.0	0.828129887581	-4.83	0.773	0.869	0.048	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
16693	43	V/A	rs927020149	0.4701	gnomAD-2.1.1	50	None	0.6582	0.5753	23.7	N	-1.364	0.41	0.012918	-1.166	0.1281	-0.953	0.109108561739	0.62	0.994833	0.444	0.392855499163	0.099	0.80067050457	-3.0	0.162	0.235	0.087	None	None	4.06E-06	0	0	0	0	None	0	None	4.06E-06	0	9.02E-06	0	None	N	None
16693	43	V/A	rs927020149	0.4701	gnomAD-3.1.2	50	None	0.6582	0.5753	23.7	N	-1.364	0.41	0.012918	-1.166	0.1281	-0.953	0.109108561739	0.62	0.994833	0.444	0.392855499163	0.099	0.80067050457	-3.0	0.162	0.235	0.087	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
16693	43	V/A	rs927020149	0.4701	gnomAD-4.0.0	50	None	0.6582	0.5753	23.7	N	-1.364	0.41	0.012918	-1.166	0.1281	-0.953	0.109108561739	0.62	0.994833	0.444	0.392855499163	0.099	0.80067050457	-3.0	0.162	0.235	0.087	None	None	5.58201E-06	0	0	0	0	None	0	0	5.58201E-06	7.63236E-06	0	0	None	N	None
16693	43	V/I	rs377141765	0.4701	gnomAD-2.1.1	50	None	0.1331	0.1107	None	N	-0.524	None	None	-0.583	None	None	None	None	None	None	None	0.906	None	None	0.162	0.503	None	None	None	2.16E-05	0	2.84E-05	9.75E-05	0	None	3.27E-05	None	2.16E-05	0	2.38E-05	0	None	N	None
16693	43	V/I	rs377141765	0.4701	gnomAD-3.1.2	50	None	0.1331	0.1107	None	N	-0.524	None	None	-0.583	None	None	None	None	None	None	None	0.906	None	None	0.162	0.503	None	None	None	3.29E-05	0	6.56E-05	0	0	None	0	0	3.29E-05	4.42E-05	2.07211E-04	0	None	N	None
16693	43	V/I	rs377141765	0.4701	1000 genomes	50	None	0.1331	0.1107	None	N	-0.524	None	None	-0.583	None	None	None	None	None	None	None	0.906	None	None	0.162	0.503	None	None	None	1.99681E-04	0	0	None	0	0	None	None	1.99681E-04	None	1E-03	None	None	N	None
16693	43	V/I	rs377141765	0.4701	gnomAD-4.0.0	50	None	0.1331	0.1107	None	N	-0.524	None	None	-0.583	None	None	None	None	None	None	None	0.906	None	None	0.162	0.503	None	None	None	3.53491E-05	0	3.33823E-05	3.38112E-05	0	None	0	0	3.53491E-05	4.49461E-05	1.09844E-05	0	None	N	None
16694	44	R/K	rs779633258	0.6563	gnomAD-2.1.1	54	None	0.4884	0.4446	None	N	0.01	None	None	-0.121	None	None	None	None	None	None	None	0.543	None	None	0.159	0.311	None	None	None	4.06E-06	6.51E-05	0	0	0	None	0	None	4.06E-06	0	0	0	None	N	None
16694	44	R/K	rs779633258	0.6563	gnomAD-3.1.2	54	None	0.4884	0.4446	None	N	0.01	None	None	-0.121	None	None	None	None	None	None	None	0.543	None	None	0.159	0.311	None	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
16694	44	R/K	rs779633258	0.6563	gnomAD-4.0.0	54	None	0.4884	0.4446	None	N	0.01	None	None	-0.121	None	None	None	None	None	None	None	0.543	None	None	0.159	0.311	None	None	None	6.58224E-06	2.41464E-05	0	0	0	None	0	0	6.58224E-06	0	0	0	None	N	None
16695	45	R/Q	rs794729451	0.6033	gnomAD-2.1.1	60	None	0.594	0.6705	None	N	0.167	None	None	-0.132	None	None	None	None	None	None	None	1.0	None	None	0.283	0.647	None	None	None	4.06E-06	0	0	0	0	None	0	None	4.06E-06	0	0	1.67224E-04	None	N	None
16695	45	R/Q	rs794729451	0.6033	gnomAD-3.1.2	60	None	0.594	0.6705	None	N	0.167	None	None	-0.132	None	None	None	None	None	None	None	1.0	None	None	0.283	0.647	None	None	None	2.63E-05	4.83E-05	0	0	0	None	0	0	2.63E-05	1.47E-05	2.07383E-04	0	None	N	None
16695	45	R/Q	rs794729451	0.6033	gnomAD-4.0.0	60	None	0.594	0.6705	None	N	0.167	None	None	-0.132	None	None	None	None	None	None	None	1.0	None	None	0.283	0.647	None	None	None	1.05435E-05	2.6738E-05	0	0	2.24366E-05	None	1.56436E-05	0	1.05435E-05	8.48028E-06	2.19674E-05	1.60318E-05	None	N	None
16696	46	K/N	rs745412383	1.1207	gnomAD-2.1.1	63	None	0.917	0.9421	26.0	N	0.215	0.5	0.024201	-0.216	0.2797	-0.5186	0.500188843923	1.28	0.999844	0.488	0.207176502487	1.0	0.861272215843	-3.7	0.276	0.657	0.027	None	None	4.06E-06	0	0	0	0	None	0	None	4.06E-06	0	9E-06	0	None	N	None
16696	46	K/N	rs745412383	1.1207	gnomAD-4.0.0	63	None	0.917	0.9421	26.0	N	0.215	0.5	0.024201	-0.216	0.2797	-0.5186	0.500188843923	1.28	0.999844	0.488	0.207176502487	1.0	0.861272215843	-3.7	0.276	0.657	0.027	None	None	1.59406E-06	0	0	0	0	None	0	0	1.59406E-06	2.86234E-06	0	0	None	N	None
16697	47	G/A	None	0.4083	gnomAD-4.0.0	64	None	0.1898	0.2002	26.8	N	None	0.39	0.028309	-0.47	0.1562	-0.8063	0.229582056961	0.415	0.999872	0.444	0.195762928549	0.974	0.868890047073	-3.57	0.197	0.509	0.515	None	None	1.59394E-06	5.67344E-05	0	0	0	None	0	0	1.59394E-06	0	0	0	None	I	None
16697	47	G/C	rs1553698627	0.4083	gnomAD-2.1.1	64	None	0.6209	0.6427	27.6	D	-0.346	0.3	0.029667	-0.716	0.4189	-0.1889	0.475146259266	2.1	0.999998	0.564	0.737189981757	1.0	0.888979017735	-5.67	0.487	0.785	0.027	None	None	4.05E-06	0	0	0	0	None	3.27E-05	None	4.05E-06	0	0	0	None	I	None
16697	47	G/C	rs1553698627	0.4083	gnomAD-4.0.0	64	None	0.6209	0.6427	27.6	D	-0.346	0.3	0.029667	-0.716	0.4189	-0.1889	0.475146259266	2.1	0.999998	0.564	0.737189981757	1.0	0.888979017735	-5.67	0.487	0.785	0.027	None	None	2.05408E-06	2.99294E-05	0	0	0	None	0	0	2.05408E-06	0	1.15988E-05	1.65859E-05	None	I	None
16697	47	G/S	rs1553698627	0.4083	gnomAD-2.1.1	64	None	0.1802	0.2051	26.3	N	-0.338	0.49	0.031264	-0.808	0.2362	-0.5975	0.440487623201	0.42	0.999993	0.323	0.226586394389	1.0	0.869719326496	-3.53	0.354	0.575	0.189	None	None	1.22E-05	0	8.73E-05	0	0	None	0	None	1.22E-05	0	0	0	None	I	None
16697	47	G/S	rs1553698627	0.4083	gnomAD-4.0.0	64	None	0.1802	0.2051	26.3	N	-0.338	0.49	0.031264	-0.808	0.2362	-0.5975	0.440487623201	0.42	0.999993	0.323	0.226586394389	1.0	0.869719326496	-3.53	0.354	0.575	0.189	None	None	6.84694E-07	0	2.23974E-05	0	0	None	0	0	6.84694E-07	0	0	0	None	I	None
16698	48	W/R	None	0.2502	gnomAD-4.0.0	65	None	0.9998	0.9999	34.0	D	None	0.48	0.031575	-1.266	0.5059	0.3381	0.615612516959	4.105	1.0	0.688	0.713184890557	1.0	0.889923334122	-11.07	0.61	0.725	0.392	None	None	1.59388E-06	0	0	0	0	None	1.8848E-05	0	1.59388E-06	0	0	0	None	N	None
16699	49	Q/R	None	0.4586	gnomAD-4.0.0	66	None	0.5678	0.7707	28.1	N	None	0.38	0.014382	-0.196	0.2525	-0.5747	0.476211014082	1.485	0.99999	0.537	0.194818534648	0.997	0.76525592804	-3.07	0.443	0.583	0.123	None	None	1.59381E-06	0	0	0	0	None	0	0	1.59381E-06	2.86198E-06	0	0	None	N	None
16700	50	T/A	None	0.4340	gnomAD-4.0.0	67	None	0.1317	0.1309	23.3	N	None	0.38	0.017225	-0.642	0.0941	-1.0303	0.0842823598617	0.9	0.980175	0.384	0.126345400529	0.012	0.700818538666	-2.87	0.074	0.161	0.591	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
16701	51	V/M	None	0.2826	gnomAD-4.0.0	68	None	0.5581	0.5727	24.8	D	None	0.34	0.026088	-0.562	0.4555	0.0279	0.465052223951	2.96	1.0	0.478	0.566956417683	1.0	0.797651290894	-2.27	0.37	0.715	0.006	None	None	1.5939E-06	0	0	0	0	None	0	0	1.5939E-06	2.8622E-06	0	0	None	N	None
16702	52	D/N	rs1417347726	0.3157	gnomAD-2.1.1	69	None	0.6566	0.6605	25.3	N	-0.741	0.54	0.023359	-0.346	0.2647	-0.5687	0.459178880736	0.255	1.0	0.481	0.218112801441	1.0	0.869208931923	-3.6	0.374	0.651	0.009	None	None	7.19E-06	0	2.84E-05	0	0	None	0	None	7.19E-06	0	7.88E-06	0	None	N	None
16702	52	D/N	rs1417347726	0.3157	gnomAD-3.1.2	69	None	0.6566	0.6605	25.3	N	-0.741	0.54	0.023359	-0.346	0.2647	-0.5687	0.459178880736	0.255	1.0	0.481	0.218112801441	1.0	0.869208931923	-3.6	0.374	0.651	0.009	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
16702	52	D/N	rs1417347726	0.3157	gnomAD-4.0.0	69	None	0.6566	0.6605	25.3	N	-0.741	0.54	0.023359	-0.346	0.2647	-0.5687	0.459178880736	0.255	1.0	0.481	0.218112801441	1.0	0.869208931923	-3.6	0.374	0.651	0.009	None	None	2.48081E-06	0	1.66973E-05	0	0	None	0	0	2.48081E-06	2.54409E-06	0	0	None	N	None
16703	53	T/A	rs778518712	0.4463	gnomAD-2.1.1	70	None	0.285	0.2537	27.3	N	-0.512	0.49	0.014073	-0.688	0.2549	-0.5683	0.458666652128	0.68	0.999995	0.347	0.207176502487	0.999	0.785023331642	-3.67	0.377	0.499	0.085	None	None	4.05E-06	0	0	0	0	None	0	None	4.05E-06	0	8.96E-06	0	None	N	None
16703	53	T/A	rs778518712	0.4463	gnomAD-4.0.0	70	None	0.285	0.2537	27.3	N	-0.512	0.49	0.014073	-0.688	0.2549	-0.5683	0.458666652128	0.68	0.999995	0.347	0.207176502487	0.999	0.785023331642	-3.67	0.377	0.499	0.085	None	None	1.59387E-06	0	0	0	0	None	0	0	1.59387E-06	2.86202E-06	0	0	None	N	None
16703	53	T/I	rs757138357	0.4463	gnomAD-2.1.1	70	None	0.6455	0.6389	28.5	D	-0.13	0.52	0.018107	-0.317	0.3938	-0.2244	0.480749730577	1.92	1.0	0.39	0.448099371145	1.0	0.861252903938	-4.5	0.415	0.757	0.008	None	None	4.05E-06	0	0	0	0	None	0	None	4.05E-06	0	8.97E-06	0	None	N	None
16703	53	T/I	rs757138357	0.4463	gnomAD-4.0.0	70	None	0.6455	0.6389	28.5	D	-0.13	0.52	0.018107	-0.317	0.3938	-0.2244	0.480749730577	1.92	1.0	0.39	0.448099371145	1.0	0.861252903938	-4.5	0.415	0.757	0.008	None	None	1.59408E-06	0	0	0	0	None	0	0	1.59408E-06	2.8622E-06	0	0	None	N	None
16703	53	T/N	rs757138357	0.4463	gnomAD-4.0.0	70	None	0.4102	0.3852	27.6	N	-0.006	0.43	0.010434	-0.453	0.3353	-0.424	0.494608543549	1.755	1.0	0.378	0.388334884743	1.0	0.837341010571	-3.67	0.376	0.701	0.268	None	None	3.18816E-06	0	0	0	0	None	0	0	3.18816E-06	2.8622E-06	1.43345E-05	0	None	N	None
16706	56	K/E	None	0.8072	gnomAD-4.0.0	83	None	0.6158	0.6829	25.9	N	None	0.47	0.020732	0.203	0.2392	-0.5902	0.543662385431	1.145	0.999986	0.521	0.358540694251	0.999	0.810395240784	-2.77	0.407	0.638	0.185	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	0	1.21507E-04	0	None	N	None
16706	56	K/R	rs879111780	0.8072	gnomAD-2.1.1	83	None	0.1275	0.1321	27.9	N	0.142	0.43	0.018926	-0.125	0.263	-0.554	0.423302696435	1.32	0.999963	0.487	0.300784259202	0.999	0.759620666504	-2.37	0.324	0.583	0.067	None	None	7.18E-06	0	2.84E-05	0	0	None	0	None	7.18E-06	0	0	1.41243E-04	None	N	None
16706	56	K/R	rs879111780	0.8072	gnomAD-3.1.2	83	None	0.1275	0.1321	27.9	N	0.142	0.43	0.018926	-0.125	0.263	-0.554	0.423302696435	1.32	0.999963	0.487	0.300784259202	0.999	0.759620666504	-2.37	0.324	0.583	0.067	None	None	1.32E-05	0	6.56E-05	0	0	None	0	0	1.32E-05	1.47E-05	0	0	None	N	None
16706	56	K/R	rs879111780	0.8072	gnomAD-4.0.0	83	None	0.1275	0.1321	27.9	N	0.142	0.43	0.018926	-0.125	0.263	-0.554	0.423302696435	1.32	0.999963	0.487	0.300784259202	0.999	0.759620666504	-2.37	0.324	0.583	0.067	None	None	6.41578E-06	0	3.39547E-05	0	0	None	0	0	6.41578E-06	7.18845E-06	0	0	None	N	None
16707	57	D/N	rs1158553720	0.7092	gnomAD-2.1.1	88	None	0.2951	0.3846	27.0	N	-0.557	0.44	0.049091	-0.265	0.2771	-0.5639	0.432164153585	0.75	1.0	0.405	0.256793551483	0.999	0.741521120071	-2.97	0.223	0.657	0.327	None	None	3.19E-05	0	0	0	6.61376E-04	None	0	None	3.19E-05	0	0	0	None	I	None
16707	57	D/N	rs1158553720	0.7092	gnomAD-3.1.2	88	None	0.2951	0.3846	27.0	N	-0.557	0.44	0.049091	-0.265	0.2771	-0.5639	0.432164153585	0.75	1.0	0.405	0.256793551483	0.999	0.741521120071	-2.97	0.223	0.657	0.327	None	None	6.58E-06	0	0	0	1.95313E-04	None	0	0	6.58E-06	0	0	0	None	I	None
16707	57	D/N	rs1158553720	0.7092	gnomAD-4.0.0	88	None	0.2951	0.3846	27.0	N	-0.557	0.44	0.049091	-0.265	0.2771	-0.5639	0.432164153585	0.75	1.0	0.405	0.256793551483	0.999	0.741521120071	-2.97	0.223	0.657	0.327	None	None	4.34139E-06	0	0	0	8.97787E-05	None	0	0	4.34139E-06	2.54401E-06	0	0	None	I	None
16708	58	T/A	rs2056500591	0.2225	gnomAD-3.1.2	89	None	0.1644	0.1756	23.3	D	None	0.29	0.036307	-0.852	0.2536	-0.5109	0.176838138355	2.34	0.994611	0.544	0.220303561663	0.625	0.615992069244	-3.2	0.278	0.471	0.084	None	None	6.58E-06	0	6.56E-05	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
16708	58	T/A	rs2056500591	0.2225	gnomAD-4.0.0	89	None	0.1644	0.1756	23.3	D	None	0.29	0.036307	-0.852	0.2536	-0.5109	0.176838138355	2.34	0.994611	0.544	0.220303561663	0.625	0.615992069244	-3.2	0.278	0.471	0.084	None	None	2.56635E-06	0	1.69745E-05	0	0	None	0	2.24719E-04	2.56635E-06	0	0	0	None	N	None
16708	58	T/N	rs777539591	0.2225	gnomAD-2.1.1	89	None	0.2841	0.3104	25.3	N	-0.752	0.35	0.025931	-0.954	0.2546	-0.5964	0.404745852777	2.015	0.998259	0.534	0.372268306217	0.989	0.696054816246	-3.23	0.284	0.465	0.023	None	None	4.04E-06	0	0	0	0	None	3.27E-05	None	4.04E-06	0	0	0	None	N	None
16708	58	T/N	rs777539591	0.2225	gnomAD-4.0.0	89	None	0.2841	0.3104	25.3	N	-0.752	0.35	0.025931	-0.954	0.2546	-0.5964	0.404745852777	2.015	0.998259	0.534	0.372268306217	0.989	0.696054816246	-3.23	0.284	0.465	0.023	None	None	1.36939E-06	0	0	0	0	None	0	0	1.36939E-06	0	2.31922E-05	0	None	N	None
16708	58	T/P	None	0.2225	gnomAD-4.0.0	89	None	0.2606	0.3205	25.4	N	None	0.3	0.045394	-0.144	0.3097	-0.4173	0.433853106296	1.915	0.998941	0.634	0.430579932962	0.989	0.630237102509	-4.0	0.488	0.527	0.055	None	None	1.59389E-06	0	0	0	0	None	0	0	1.59389E-06	0	0	3.03214E-05	None	N	None
16708	58	T/S	None	0.2225	gnomAD-4.0.0	89	None	0.2685	0.2743	24.9	N	None	0.34	0.034633	-1.237	0.2253	-0.6114	0.259053091459	2.195	0.979866	0.569	0.199424873507	0.891	0.635790288448	-2.53	0.286	0.475	0.06	None	None	1.36939E-06	0	0	0	0	None	0	0	1.36939E-06	1.79969E-06	0	0	None	N	None
16709	59	K/N	rs1244376906	0.6790	gnomAD-2.1.1	90	None	0.887	0.863	25.4	N	-0.138	0.44	0.01295	-0.207	0.186	-0.7844	0.476807163087	1.035	0.994481	0.508	0.165133752707	0.999	0.772472023964	-3.73	0.241	0.701	0.093	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.49E-05	0	None	N	None
16709	59	K/N	rs1244376906	0.6790	gnomAD-3.1.2	90	None	0.887	0.863	25.4	N	-0.138	0.44	0.01295	-0.207	0.186	-0.7844	0.476807163087	1.035	0.994481	0.508	0.165133752707	0.999	0.772472023964	-3.73	0.241	0.701	0.093	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
16709	59	K/N	rs1244376906	0.6790	gnomAD-4.0.0	90	None	0.887	0.863	25.4	N	-0.138	0.44	0.01295	-0.207	0.186	-0.7844	0.476807163087	1.035	0.994481	0.508	0.165133752707	0.999	0.772472023964	-3.73	0.241	0.701	0.093	None	None	6.58328E-06	0	0	0	0	None	0	0	6.58328E-06	1.47223E-05	0	0	None	N	None
16709	59	K/Q	rs755961446	0.6790	gnomAD-2.1.1	90	None	0.4228	0.3775	25.5	N	-0.037	0.46	0.017497	-0.247	0.2127	-0.6197	0.456399025932	1.16	0.999928	0.491	0.165133752707	0.999	0.719133496284	-3.0	0.355	0.697	0.209	None	None	1.21E-05	0	0	0	0	None	9.81E-05	None	1.21E-05	0	0	0	None	N	None
16709	59	K/Q	rs755961446	0.6790	gnomAD-4.0.0	90	None	0.4228	0.3775	25.5	N	-0.037	0.46	0.017497	-0.247	0.2127	-0.6197	0.456399025932	1.16	0.999928	0.491	0.165133752707	0.999	0.719133496284	-3.0	0.355	0.697	0.209	None	None	7.96952E-06	0	0	0	0	None	0	0	7.96952E-06	0	7.1662E-05	0	None	N	None
16709	59	K/R	rs2056499137	0.6790	gnomAD-3.1.2	90	None	0.1137	0.1145	30.0	N	None	0.51	0.01405	-0.353	0.2301	-0.6158	0.390847452688	1.11	0.999342	0.443	0.194818534648	0.998	0.690021514893	-2.0	0.191	0.591	0.1	None	None	6.58E-06	0	0	0	0	None	9.41E-05	0	6.58E-06	0	0	0	None	N	None
16709	59	K/R	rs2056499137	0.6790	gnomAD-4.0.0	90	None	0.1137	0.1145	30.0	N	None	0.51	0.01405	-0.353	0.2301	-0.6158	0.390847452688	1.11	0.999342	0.443	0.194818534648	0.998	0.690021514893	-2.0	0.191	0.591	0.1	None	None	2.56639E-06	0	0	0	0	None	1.5704E-05	0	2.56639E-06	0	0	2.8516E-05	None	N	None
16711	61	T/R	None	0.4425	gnomAD-4.0.0	92	None	0.4856	0.4311	28.7	N	None	0.13	0.018413	-0.21	0.352	-0.3787	0.460280711038	1.275	0.999995	0.533	0.594705806306	0.993	0.708012163639	-4.4	0.443	0.797	0.021	None	None	1.59393E-06	0	0	0	0	None	0	0	1.59393E-06	2.8622E-06	0	0	None	N	None
16712	62	V/D	None	0.1168	gnomAD-4.0.0	93	None	0.9983	0.9993	29.5	D	None	0.08	0.058433	-2.384	0.4374	-0.0306	0.587031713447	2.685	1.0	0.735	0.847127511703	1.0	0.814548254013	-5.67	0.687	0.84	0.034	None	None	6.84701E-07	0	0	0	0	None	0	0	6.84701E-07	8.9986E-07	0	0	None	N	None
16712	62	V/G	rs1314552701	0.1168	gnomAD-2.1.1	93	None	0.968	0.98	29.0	D	-3.055	0.05	0.072892	-2.495	0.5885	0.4781	0.527292994097	3.97	1.0	0.715	0.905301469533	1.0	0.73799264431	-5.57	0.672	0.848	0.001	None	None	4.04E-06	0	0	0	0	None	3.27E-05	None	4.04E-06	0	0	0	None	N	None
16712	62	V/G	rs1314552701	0.1168	gnomAD-4.0.0	93	None	0.968	0.98	29.0	D	-3.055	0.05	0.072892	-2.495	0.5885	0.4781	0.527292994097	3.97	1.0	0.715	0.905301469533	1.0	0.73799264431	-5.57	0.672	0.848	0.001	None	None	4.1082E-06	0	0	0	0	None	0	0	4.1082E-06	0	6.95781E-05	0	None	N	None
16712	62	V/I	None	0.1168	gnomAD-4.0.0	93	None	0.13	0.1251	24.1	N	None	0.28	0.010062	-0.546	0.3182	-0.4477	0.420894402933	1.07	0.999998	0.471	0.453772157364	0.997	0.702876448631	-0.73	0.253	0.547	0.458	None	None	6.84696E-07	0	0	0	2.53537E-05	None	0	0	6.84696E-07	0	0	0	None	N	None
16712	62	V/L	rs2056497488	0.1168	gnomAD-4.0.0	93	None	0.7603	0.793	24.4	N	None	0.48	0.013669	-0.546	0.3514	-0.3712	0.458049767139	1.8	0.999999	0.492	0.370424759081	0.997	0.802213430405	-2.3	0.31	0.666	0.02	None	None	6.84696E-07	0	0	0	0	None	0	0	6.84696E-07	0	1.15964E-05	0	None	N	None
16713	63	T/I	rs2056496324	0.5299	gnomAD-3.1.2	94	None	0.3035	0.3684	27.8	D	None	0.22	0.018355	-0.139	0.3259	-0.3298	0.341713156885	1.685	0.999007	0.526	0.56380075071	0.782	0.713640809059	-4.3	0.303	0.712	0.037	None	None	6.58E-06	0	6.56E-05	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
16713	63	T/I	rs2056496324	0.5299	gnomAD-4.0.0	94	None	0.3035	0.3684	27.8	D	None	0.22	0.018355	-0.139	0.3259	-0.3298	0.341713156885	1.685	0.999007	0.526	0.56380075071	0.782	0.713640809059	-4.3	0.303	0.712	0.037	None	None	6.58233E-06	0	6.55824E-05	0	0	None	0	0	6.58233E-06	0	0	0	None	N	None
16714	64	P/L	rs1309789816	0.6333	gnomAD-2.1.1	96	None	0.8043	0.8084	31.0	N	0.216	0.44	0.01654	-0.28	0.3543	-0.3651	0.469182032742	2.085	1.0	0.502	0.675375996808	1.0	0.814552545547	-7.37	0.462	0.665	0.022	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.95E-06	0	None	N	None
16714	64	P/L	rs1309789816	0.6333	gnomAD-4.0.0	96	None	0.8043	0.8084	31.0	N	0.216	0.44	0.01654	-0.28	0.3543	-0.3651	0.469182032742	2.085	1.0	0.502	0.675375996808	1.0	0.814552545547	-7.37	0.462	0.665	0.022	None	None	2.05411E-06	0	0	0	0	None	0	0	2.05411E-06	2.69959E-06	0	0	None	N	None
16715	65	L/V	rs1181230555	0.1204	gnomAD-2.1.1	97	None	0.6685	0.6158	22.7	D	-1.772	-1.9	0.020828	-1.735	0.7068	0.3661	0.465770963553	2.72	0.999146	0.775	0.734837467084	0.999	0.731506824493	-2.37	0.644	0.838	0.083	None	None	6.38E-05	2.29568E-04	0	0	0	None	0	None	6.38E-05	0	0	0	None	N	None
16715	65	L/V	rs1181230555	0.1204	gnomAD-3.1.2	97	None	0.6685	0.6158	22.7	D	-1.772	-1.9	0.020828	-1.735	0.7068	0.3661	0.465770963553	2.72	0.999146	0.775	0.734837467084	0.999	0.731506824493	-2.37	0.644	0.838	0.083	None	None	1.97E-05	7.24E-05	0	0	0	None	0	0	1.97E-05	0	0	0	None	N	None
16715	65	L/V	rs1181230555	0.1204	gnomAD-4.0.0	97	None	0.6685	0.6158	22.7	D	-1.772	-1.9	0.020828	-1.735	0.7068	0.3661	0.465770963553	2.72	0.999146	0.775	0.734837467084	0.999	0.731506824493	-2.37	0.644	0.838	0.083	None	None	7.69888E-06	1.01616E-04	0	0	0	None	0	0	7.69888E-06	0	0	0	None	N	None
16717	67	E/D	rs369623681	0.5657	gnomAD-2.1.1	99	None	0.2738	0.4658	22.7	D	-0.52	0.33	0.0177	-0.591	0.2068	-0.7367	0.0996588253401	2.495	0.99941	0.449	0.227260227426	0.434	0.687946438789	-2.27	0.157	0.206	0.034	None	None	1.08E-05	0	0	0	0	None	3.27E-05	None	1.08E-05	0	1.57E-05	0	None	N	None
16717	67	E/D	rs369623681	0.5657	gnomAD-3.1.2	99	None	0.2738	0.4658	22.7	D	-0.52	0.33	0.0177	-0.591	0.2068	-0.7367	0.0996588253401	2.495	0.99941	0.449	0.227260227426	0.434	0.687946438789	-2.27	0.157	0.206	0.034	None	None	1.97E-05	2.42E-05	0	0	0	None	0	0	1.97E-05	2.94E-05	0	0	None	N	None
16717	67	E/D	rs369623681	0.5657	gnomAD-4.0.0	99	None	0.2738	0.4658	22.7	D	-0.52	0.33	0.0177	-0.591	0.2068	-0.7367	0.0996588253401	2.495	0.99941	0.449	0.227260227426	0.434	0.687946438789	-2.27	0.157	0.206	0.034	None	None	2.17067E-05	1.33679E-05	0	0	0	None	0	0	2.17067E-05	2.54409E-05	4.3929E-05	0	None	N	None
16718	68	G/V	None	0.3761	gnomAD-4.0.0	100	None	0.9401	0.9746	26.6	D	None	-0.02	0.045191	-0.445	0.5493	0.23	0.518063289252	3.635	1.0	0.617	0.863703880688	1.0	0.768544256687	-7.13	0.662	0.841	0.015	None	None	1.59394E-06	0	0	0	0	None	0	0	1.59394E-06	0	1.43332E-05	0	None	N	None
16719	69	S/Y	rs1416967090	0.1347	gnomAD-2.1.1	102	None	0.6693	0.7443	26.3	D	-0.83	0.32	0.045319	-0.586	0.4158	-0.1474	0.419956848209	2.43	0.999996	0.622	0.746976035754	0.975	0.684540688992	-4.63	0.507	0.598	0.025	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.94E-06	0	None	N	None
16719	69	S/Y	rs1416967090	0.1347	gnomAD-4.0.0	102	None	0.6693	0.7443	26.3	D	-0.83	0.32	0.045319	-0.586	0.4158	-0.1474	0.419956848209	2.43	0.999996	0.622	0.746976035754	0.975	0.684540688992	-4.63	0.507	0.598	0.025	None	None	1.594E-06	0	0	0	0	None	0	0	1.594E-06	2.86244E-06	0	0	None	N	None
16721	71	Y/C	None	0.1183	gnomAD-4.0.0	104	None	0.9294	0.9482	32.0	D	None	-2.5	0.227312	-1.803	0.8983	1.0622	0.517459491388	4.145	1.0	0.908	0.926672064637	1.0	0.858398675919	-7.1	0.884	0.863	0.122	None	None	1.36945E-06	0	0	0	0	None	0	0	1.36945E-06	1.79979E-06	0	0	None	N	None
16724	74	R/Q	rs768793035	0.0968	gnomAD-2.1.1	107	None	0.8934	0.9434	29.6	D	-1.223	0.24	0.029992	-1.251	0.4814	0.0446	0.496624975885	3.11	1.0	0.714	0.356484672536	1.0	0.679617285728	-3.13	0.501	0.755	0.091	None	None	7.17E-06	0	0	0	0	None	0	None	7.17E-06	0	7.85E-06	1.41084E-04	None	N	None
16724	74	R/Q	rs768793035	0.0968	gnomAD-3.1.2	107	None	0.8934	0.9434	29.6	D	-1.223	0.24	0.029992	-1.251	0.4814	0.0446	0.496624975885	3.11	1.0	0.714	0.356484672536	1.0	0.679617285728	-3.13	0.501	0.755	0.091	None	None	1.32E-05	0	0	0	0	None	0	0	1.32E-05	2.94E-05	0	0	None	N	None
16724	74	R/Q	rs768793035	0.0968	gnomAD-4.0.0	107	None	0.8934	0.9434	29.6	D	-1.223	0.24	0.029992	-1.251	0.4814	0.0446	0.496624975885	3.11	1.0	0.714	0.356484672536	1.0	0.679617285728	-3.13	0.501	0.755	0.091	None	None	2.3568E-05	4.01027E-05	0	0	0	None	0	1.64745E-04	2.3568E-05	2.88337E-05	0	0	None	N	None
16726	76	A/T	None	0.0559	gnomAD-4.0.0	109	None	0.7966	0.7397	25.0	N	None	0.4	0.02124	-1.632	0.2566	-0.5761	0.457598942377	1.665	1.0	0.427	0.310147130316	1.0	0.795574903488	-3.07	0.381	0.719	0.246	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
16727	77	A/T	rs766576103	0.0835	gnomAD-2.1.1	110	None	0.8647	0.8956	27.2	D	-1.966	-1.02	0.060407	-1.988	0.7539	0.719	0.457598942377	3.41	1.0	0.8	0.625265535518	1.0	0.655240118504	-3.2	0.795	0.797	0.047	None	None	1.21E-05	0	0	0	0	None	9.81E-05	None	1.21E-05	0	0	0	None	N	None
16727	77	A/T	rs766576103	0.0835	gnomAD-4.0.0	110	None	0.8647	0.8956	27.2	D	-1.966	-1.02	0.060407	-1.988	0.7539	0.719	0.457598942377	3.41	1.0	0.8	0.625265535518	1.0	0.655240118504	-3.2	0.795	0.797	0.047	None	None	4.10832E-06	0	0	0	0	None	0	0	4.10832E-06	0	6.95878E-05	0	None	N	None
16727	77	A/V	None	0.0835	gnomAD-4.0.0	110	None	0.8499	0.9229	31.0	D	None	-0.99	0.075514	-1.357	0.7423	0.7418	0.462690307121	3.485	1.0	0.804	0.787238543218	1.0	0.688280344009	-3.07	0.78	0.711	0.204	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
16730	80	A/T	None	0.5543	gnomAD-4.0.0	113	None	0.251	0.2032	28.6	N	None	0.43	0.021281	-0.515	0.2392	-0.6565	0.41067748467	1.38	0.999911	0.451	0.335414705075	0.993	0.764061629772	-2.93	0.198	0.633	0.094	None	None	3.42348E-06	0	0	0	0	None	0	0	3.42348E-06	4.49938E-06	0	0	None	I	None
16730	80	A/V	rs763483590	0.5543	gnomAD-2.1.1	113	None	0.3778	0.303	27.3	N	-0.03	0.37	0.015836	-0.302	0.149	-0.8543	0.226139576742	1.31	0.999929	0.485	0.483301346737	0.955	0.774365365505	-3.1	0.213	0.417	0.047	None	None	4.04E-06	0	0	0	5.65E-05	None	0	None	4.04E-06	0	0	0	None	I	None
16730	80	A/V	rs763483590	0.5543	gnomAD-4.0.0	113	None	0.3778	0.303	27.3	N	-0.03	0.37	0.015836	-0.302	0.149	-0.8543	0.226139576742	1.31	0.999929	0.485	0.483301346737	0.955	0.774365365505	-3.1	0.213	0.417	0.047	None	None	1.59398E-06	0	0	0	2.79111E-05	None	0	0	1.59398E-06	0	0	0	None	I	None
16731	81	I/T	None	0.6452	gnomAD-4.0.0	114	None	0.1946	0.3223	24.1	N	None	0.43	0.043172	-0.447	0.1554	-0.6119	0.188820646202	2.21	0.625919	0.473	0.511162291539	0.549	0.563604295254	-3.52	0.225	0.362	0.114	None	None	1.59386E-06	0	0	0	0	None	0	0	1.59386E-06	2.86236E-06	0	0	None	I	None
16731	81	I/V	None	0.6452	gnomAD-4.0.0	114	None	0.066	0.0719	20.9	N	None	0.5	0.004796	-0.256	0.0621	-1.0248	0.0712667058525	-0.43	0.95493	0.478	0.148003135375	0.001	0.363322466612	-0.39	0.072	0.172	0.741	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
16732	82	G/R	rs1419646565	0.1720	gnomAD-2.1.1	115	None	0.9861	0.9796	25.5	D	-0.449	-0.35	0.103251	-0.679	0.6734	0.6323	0.506463245118	4.165	1.0	0.919	0.857878773519	1.0	0.865352988243	-6.47	0.736	0.927	0.002	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.92E-06	0	None	I	None
16732	82	G/R	rs1419646565	0.1720	gnomAD-4.0.0	115	None	0.9861	0.9796	25.5	D	-0.449	-0.35	0.103251	-0.679	0.6734	0.6323	0.506463245118	4.165	1.0	0.919	0.857878773519	1.0	0.865352988243	-6.47	0.736	0.927	0.002	None	None	1.59388E-06	0	0	0	0	None	0	0	1.59388E-06	2.86239E-06	0	0	None	I	None
16734	84	S/G	rs1227059346	0.0966	gnomAD-3.1.2	118	None	0.1821	0.1751	23.4	N	None	1.0	0.015458	-1.161	0.0755	-1.0509	0.0832091256479	0.28	0.99999	0.484	0.0762999501168	0.104	0.642720520496	-2.83	0.102	0.461	0.174	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
16734	84	S/G	rs1227059346	0.0966	gnomAD-4.0.0	118	None	0.1821	0.1751	23.4	N	None	1.0	0.015458	-1.161	0.0755	-1.0509	0.0832091256479	0.28	0.99999	0.484	0.0762999501168	0.104	0.642720520496	-2.83	0.102	0.461	0.174	None	None	6.5825E-06	0	0	0	0	None	0	0	6.5825E-06	1.47206E-05	0	0	None	N	None
16735	85	D/E	None	0.8083	gnomAD-4.0.0	119	None	0.1983	0.1987	23.2	N	None	0.53	0.00867	-0.455	0.0548	-1.0236	0.0920060912428	-0.295	0.978403	0.404	0.137902524267	0.248	0.665945827961	-1.87	0.089	0.168	0.623	None	None	6.84702E-07	0	0	0	0	None	0	0	6.84702E-07	8.99883E-07	0	0	None	I	None
16735	85	D/N	rs773927256	0.8083	gnomAD-2.1.1	119	None	0.1968	0.1972	25.3	N	-0.258	0.42	0.056975	-0.351	0.2457	-0.6368	0.355846640087	1.355	0.999896	0.4	0.223847106136	0.996	0.686941742897	-3.17	0.224	0.652	0.064	None	None	8.07E-06	0	2.91E-05	0	5.65E-05	None	0	None	8.07E-06	0	0	0	None	I	None
16735	85	D/N	rs773927256	0.8083	gnomAD-3.1.2	119	None	0.1968	0.1972	25.3	N	-0.258	0.42	0.056975	-0.351	0.2457	-0.6368	0.355846640087	1.355	0.999896	0.4	0.223847106136	0.996	0.686941742897	-3.17	0.224	0.652	0.064	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	0	2.07814E-04	0	None	I	None
16735	85	D/N	rs773927256	0.8083	gnomAD-4.0.0	119	None	0.1968	0.1972	25.3	N	-0.258	0.42	0.056975	-0.351	0.2457	-0.6368	0.355846640087	1.355	0.999896	0.4	0.223847106136	0.996	0.686941742897	-3.17	0.224	0.652	0.064	None	None	1.41157E-05	0	3.3942E-05	0	0	None	0	0	1.41157E-05	9.58598E-06	5.36567E-05	2.85079E-05	None	I	None
16736	86	Y/N	None	0.2489	gnomAD-4.0.0	120	None	0.8338	0.7867	27.9	N	None	0.54	0.043187	-2.108	0.304	-0.4464	0.564998201428	2.055	0.999926	0.472	0.676040837911	0.998	0.757850527763	-6.1	0.535	0.721	0.03	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
16737	87	T/A	None	0.2041	gnomAD-4.0.0	121	None	0.086	0.0803	24.2	N	None	0.57	0.04524	-1.034	0.1459	-0.857	0.0855558956097	1.5	0.761938	0.461	0.110078149338	0.005	0.498260200024	-2.19	0.111	0.365	0.37	None	None	1.59394E-06	0	0	0	0	None	0	0	1.59394E-06	2.86246E-06	0	0	None	N	None
16737	87	T/I	None	0.2041	gnomAD-4.0.0	121	None	0.2203	0.2355	23.3	N	None	0.52	0.075324	-0.002	0.1478	-0.7561	0.0937571764374	2.05	0.684231	0.62	0.234412748748	0.012	0.574801802635	-2.82	0.106	0.515	0.471	None	None	3.60097E-06	0	0	0	0	None	0	0	3.60097E-06	3.93751E-06	0	0	None	N	None
16738	88	E/G	None	0.3100	gnomAD-4.0.0	122	None	0.8436	0.7982	31.0	D	None	0.46	0.046163	-0.84	0.3591	-0.2621	0.498122856725	2.4	1.0	0.289	0.454987352986	0.999	0.711705267429	-5.33	0.431	0.741	0.008	None	None	3.18788E-06	0	0	0	0	None	0	0	3.18788E-06	5.72505E-06	0	0	None	N	None
16738	88	E/K	rs148018042	0.3100	gnomAD-2.1.1	122	None	0.8444	0.8054	None	N	0.505	None	None	-0.174	None	None	None	None	None	None	None	1.0	None	None	0.352	0.82	None	None	None	1.46918E-04	4.14E-05	0	0	1.04112E-04	None	2.94426E-04	None	1.46918E-04	8.01E-05	2.03896E-04	1.41044E-04	None	N	None
16738	88	E/K	rs148018042	0.3100	gnomAD-3.1.2	122	None	0.8444	0.8054	None	N	0.505	None	None	-0.174	None	None	None	None	None	None	None	1.0	None	None	0.352	0.82	None	None	None	1.84232E-04	0	1.9667E-04	0	1.94932E-04	None	9.42E-05	0	1.84232E-04	3.23767E-04	2.07383E-04	0	None	N	None
16738	88	E/K	rs148018042	0.3100	1000 genomes	122	None	0.8444	0.8054	None	N	0.505	None	None	-0.174	None	None	None	None	None	None	None	1.0	None	None	0.352	0.82	None	None	None	3.99361E-04	0	0	None	0	1E-03	None	None	3.99361E-04	None	1E-03	None	None	N	None
16738	88	E/K	rs148018042	0.3100	gnomAD-4.0.0	122	None	0.8444	0.8054	None	N	0.505	None	None	-0.174	None	None	None	None	None	None	None	1.0	None	None	0.352	0.82	None	None	None	2.19528E-04	4.00267E-05	5.00601E-05	0	8.97263E-05	None	4.6897E-05	0	2.19528E-04	2.67136E-04	1.53809E-04	1.92314E-04	None	N	None
16739	89	I/V	rs1553698265	0.1563	gnomAD-4.0.0	123	None	0.0797	0.0665	23.0	N	None	0.67	0.010269	-1.19	0.0747	-1.0231	0.0704899027279	-0.48	0.922516	0.209	0.21737058555	None	0.402643233538	-0.72	0.064	0.212	0.634	None	None	1.59395E-06	5.67472E-05	0	0	0	None	0	0	1.59395E-06	0	0	0	None	N	None
16740	90	E/G	rs1314963445	1.0367	gnomAD-3.1.2	124	None	0.1807	0.2012	24.9	N	-0.056	0.61	0.040283	-0.135	0.0947	-0.9566	0.0980872584222	1.775	0.72076	0.286	0.235038932564	None	0.620171189308	-1.82	0.106	0.283	0.302	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	I	None
16740	90	E/G	rs1314963445	1.0367	gnomAD-4.0.0	124	None	0.1807	0.2012	24.9	N	-0.056	0.61	0.040283	-0.135	0.0947	-0.9566	0.0980872584222	1.775	0.72076	0.286	0.235038932564	None	0.620171189308	-1.82	0.106	0.283	0.302	None	None	6.57903E-06	2.41441E-05	0	0	0	None	0	0	6.57903E-06	0	0	0	None	I	None
16740	90	E/K	rs771586396	1.0367	gnomAD-2.1.1	124	None	0.3313	0.3254	23.6	N	0.737	0.64	0.062244	0.341	0.1305	-0.9314	0.105254575492	1.315	0.96371	0.383	0.258779203287	0.058	0.735964000225	-2.06	0.115	0.456	0.355	None	None	4.04E-06	0	0	0	0	None	3.27E-05	None	4.04E-06	0	0	0	None	I	None
16740	90	E/K	rs771586396	1.0367	gnomAD-4.0.0	124	None	0.3313	0.3254	23.6	N	0.737	0.64	0.062244	0.341	0.1305	-0.9314	0.105254575492	1.315	0.96371	0.383	0.258779203287	0.058	0.735964000225	-2.06	0.115	0.456	0.355	None	None	2.05414E-06	0	0	0	0	None	0	0	2.05414E-06	1.79978E-06	1.16012E-05	0	None	I	None
16741	91	D/E	rs372658275	0.8674	gnomAD-3.1.2	125	None	0.537	0.5567	24.0	N	None	0.29	0.018121	-0.272	0.1707	-0.7878	0.446550992324	-0.415	0.998544	0.241	0.258283824007	0.999	0.78326433897	-2.83	0.159	0.503	0.117	None	None	1.97E-05	4.83E-05	6.55E-05	0	0	None	0	0	1.97E-05	0	0	0	None	I	None
16741	91	D/E	rs372658275	0.8674	gnomAD-4.0.0	125	None	0.537	0.5567	24.0	N	None	0.29	0.018121	-0.272	0.1707	-0.7878	0.446550992324	-0.415	0.998544	0.241	0.258283824007	0.999	0.78326433897	-2.83	0.159	0.503	0.117	None	None	3.10078E-06	4.00866E-05	1.66911E-05	0	0	None	0	0	3.10078E-06	0	0	1.60292E-05	None	I	None
16743	93	V/L	None	0.2413	gnomAD-4.0.0	127	None	0.5909	0.5663	24.2	D	None	0.06	0.025655	-0.106	0.4496	-0.125	0.45004994787	1.91	1.0	0.31	0.483301346737	0.994	0.823672175407	-2.4	0.315	0.649	0.017	None	None	1.59407E-06	0	0	0	2.79127E-05	None	0	0	1.59407E-06	0	0	0	None	N	None
16743	93	V/M	None	0.2413	gnomAD-4.0.0	127	None	0.5352	0.4904	24.6	D	None	-0.01	0.023571	-0.188	0.5646	0.2106	0.463846803272	2.165	1.0	0.338	0.528662862717	0.999	0.843512058258	-2.4	0.353	0.749	0.004	None	None	1.59407E-06	0	0	0	2.79127E-05	None	0	0	1.59407E-06	0	0	0	None	N	None
16745	95	A/T	rs2056479723	0.0689	gnomAD-3.1.2	130	None	0.912	0.8822	25.4	D	None	0.26	0.039701	-1.798	0.5389	0.1888	0.456114532304	1.7	1.0	0.309	0.509463317838	1.0	0.767978787422	-2.9	0.393	0.749	0.256	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
16745	95	A/T	rs2056479723	0.0689	gnomAD-4.0.0	130	None	0.912	0.8822	25.4	D	None	0.26	0.039701	-1.798	0.5389	0.1888	0.456114532304	1.7	1.0	0.309	0.509463317838	1.0	0.767978787422	-2.9	0.393	0.749	0.256	None	None	1.86092E-06	1.33686E-05	0	0	0	None	0	0	1.86092E-06	0	1.09967E-05	1.60349E-05	None	N	None
16746	96	K/Q	None	0.3891	gnomAD-4.0.0	131	None	0.6006	0.5263	33.0	N	None	0.15	0.022902	-0.363	0.4082	-0.1776	0.476305088485	1.69	0.999999	0.348	0.359557344763	0.999	0.720870494843	-3.07	0.354	0.734	0.115	None	None	4.80129E-06	0	0	0	0	None	0	0	4.80129E-06	5.25001E-06	0	0	None	N	None
16746	96	K/T	rs1367329297	0.3891	gnomAD-3.1.2	131	None	0.7796	0.7533	29.4	N	None	0.13	0.040001	-0.626	0.4082	-0.1776	0.502031715641	2.26	1.0	0.392	0.438593652726	0.999	0.76172041893	-4.47	0.506	0.649	0.038	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
16746	96	K/T	rs1367329297	0.3891	gnomAD-4.0.0	131	None	0.7796	0.7533	29.4	N	None	0.13	0.040001	-0.626	0.4082	-0.1776	0.502031715641	2.26	1.0	0.392	0.438593652726	0.999	0.76172041893	-4.47	0.506	0.649	0.038	None	None	2.0302E-06	0	0	0	0	None	0	0	2.0302E-06	2.41009E-06	0	0	None	N	None
16747	97	D/G	rs745559631	0.5953	gnomAD-2.1.1	132	None	0.8201	0.9462	31.0	D	-0.083	0.11	0.027952	-0.373	0.4113	-0.1711	0.527187201929	2.25	1.0	0.25	0.391000631824	1.0	0.821663022041	-5.03	0.399	0.766	0.021	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.93E-06	0	None	N	None

Whole Population MAF	African (AFR)	Latin American (AMR)
Amish (AMS)	Ashkenazi Jewish (ASJ)	East Asian (EAS)
European/1KGP (EUR)	Finnish (FIN)	Middle Eastern (MDE)
Non-Finnish European (NFE)	South Asian (SAS)	Other (OTH)

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