TITINdb

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Position	Domain position	SAV	Structural Position	RS	Q(SASA)	Disease	Source	MAF
8264	1	P/A	1	None	0.1540	None	gnomAD-4.0.0	1.63066E-06
8264	1	P/L	1	rs1235369035	0.1540	None	gnomAD-2.1.1	8.38E-06
8264	1	P/L	1	rs1235369035	0.1540	None	gnomAD-4.0.0	4.14748E-06
8265	2	Y/N	2	None	0.4846	None	gnomAD-4.0.0	1.6283E-06
8266	3	F/Y	3	rs768252647	0.1707	None	gnomAD-2.1.1	8.33E-06
8266	3	F/Y	3	rs768252647	0.1707	None	gnomAD-4.0.0	1.78772E-05
8267	4	I/F	4	rs534974639	0.6069	None	gnomAD-2.1.1	8.33E-06
8267	4	I/F	4	rs534974639	0.6069	None	gnomAD-3.1.2	1.97E-05
8267	4	I/F	4	rs534974639	0.6069	None	1000 genomes	3.99361E-04
8267	4	I/F	4	rs534974639	0.6069	None	gnomAD-4.0.0	6.87145E-06
8267	4	I/T	4	None	0.6069	None	gnomAD-4.0.0	1.62361E-06
8269	6	P/L	7	rs960099770	0.4535	None	gnomAD-4.0.0	1.62141E-06
8271	8	E/K	9	None	0.7731	None	gnomAD-4.0.0	4.13603E-06
8271	8	E/Q	9	None	0.7731	None	gnomAD-4.0.0	6.89338E-07
8272	9	H/L	11	None	0.6108	None	gnomAD-4.0.0	6.88821E-07
8272	9	H/P	11	rs1299797032	0.6108	None	gnomAD-2.1.1	4.13E-06
8272	9	H/P	11	rs1299797032	0.6108	None	gnomAD-4.0.0	1.37764E-06
8272	9	H/Q	11	None	0.6108	None	gnomAD-4.0.0	1.61603E-06
8272	9	H/Y	11	None	0.6108	None	gnomAD-4.0.0	2.068E-06
8273	10	V/A	13	None	0.2964	None	gnomAD-4.0.0	1.20032E-06
8273	10	V/M	13	None	0.2964	None	gnomAD-4.0.0	1.61611E-06
8274	11	E/K	14	rs72648981	0.8341	None	gnomAD-2.1.1	2.30508E-03
8274	11	E/K	14	rs72648981	0.8341	None	gnomAD-3.1.2	2.32668E-03
8274	11	E/K	14	rs72648981	0.8341	None	1000 genomes	5.99042E-04
8274	11	E/K	14	rs72648981	0.8341	None	gnomAD-4.0.0	2.97975E-03
8275	12	A/T	16	rs771947778	0.2881	None	gnomAD-2.1.1	4.13E-06
8275	12	A/T	16	rs771947778	0.2881	None	gnomAD-4.0.0	1.10167E-05
8277	14	I/T	23	rs745818162	0.7584	None	gnomAD-2.1.1	1.1E-05
8277	14	I/T	23	rs745818162	0.7584	None	gnomAD-3.1.2	6.57E-06
8277	14	I/T	23	rs745818162	0.7584	None	gnomAD-4.0.0	7.7693E-06
8278	15	G/A	24	rs778611558	0.2506	None	gnomAD-2.1.1	4.75E-05
8278	15	G/A	24	rs778611558	0.2506	None	gnomAD-3.1.2	3.29E-05
8278	15	G/A	24	rs778611558	0.2506	None	gnomAD-4.0.0	3.36686E-05
8278	15	G/R	24	rs1406754899	0.2506	None	gnomAD-2.1.1	4.12E-06
8278	15	G/R	24	rs1406754899	0.2506	None	gnomAD-4.0.0	1.6128E-06
8280	17	P/L	26	rs375219172	0.4169	None	gnomAD-2.1.1	8.23E-06
8280	17	P/L	26	rs375219172	0.4169	None	gnomAD-3.1.2	6.57E-06
8280	17	P/L	26	rs375219172	0.4169	None	gnomAD-4.0.0	8.09428E-06
8280	17	P/R	26	rs375219172	0.4169	None	gnomAD-3.1.2	1.31E-05
8280	17	P/R	26	rs375219172	0.4169	None	gnomAD-4.0.0	1.86791E-06
8281	18	A/E	28	rs1474165122	0.2053	None	gnomAD-2.1.1	8.22E-06
8281	18	A/E	28	rs1474165122	0.2053	None	gnomAD-4.0.0	4.83065E-06
8281	18	A/T	28	rs2077783832	0.2053	None	gnomAD-4.0.0	1.61075E-06
8282	19	T/A	29	rs2077783131	0.6361	None	gnomAD-4.0.0	4.80129E-06
8282	19	T/I	29	None	0.6361	None	gnomAD-4.0.0	1.20032E-06
8283	20	L/F	30	rs1454021604	0.1370	None	gnomAD-3.1.2	6.57E-06
8283	20	L/F	30	rs1454021604	0.1370	None	gnomAD-4.0.0	3.73346E-06
8283	20	L/V	30	rs1408912599	0.1370	None	gnomAD-3.1.2	6.57E-06
8283	20	L/V	30	rs1408912599	0.1370	None	gnomAD-4.0.0	6.57151E-06
8284	21	Q/E	31	None	0.4974	None	gnomAD-4.0.0	2.40066E-06
8284	21	Q/L	31	None	0.4974	None	gnomAD-4.0.0	3.21576E-06
8285	22	C/G	33	rs757040162	0.0981	None	gnomAD-2.1.1	4.1E-06
8285	22	C/R	33	None	0.0981	None	gnomAD-4.0.0	6.87163E-07
8285	22	C/S	33	rs757040162	0.0981	None	gnomAD-2.1.1	4.1E-06
8285	22	C/S	33	rs757040162	0.0981	None	gnomAD-4.0.0	1.37433E-06
8286	23	K/E	34	rs1454054276	0.3835	None	gnomAD-2.1.1	4.1E-06
8286	23	K/E	34	rs1454054276	0.3835	None	gnomAD-4.0.0	3.50342E-05
8286	23	K/Q	34	rs1454054276	0.3835	None	gnomAD-4.0.0	1.37389E-06
8286	23	K/R	34	None	0.3835	None	gnomAD-4.0.0	6.86896E-07
8287	24	V/A	35	rs2077779717	0.1183	None	gnomAD-4.0.0	1.60527E-06
8288	25	D/G	38	None	0.3627	None	gnomAD-4.0.0	1.20033E-06
8288	25	D/N	38	rs372538009	0.3627	None	gnomAD-3.1.2	6.57E-06
8288	25	D/N	38	rs372538009	0.3627	None	gnomAD-4.0.0	2.57995E-06
8290	27	T/N	41	None	0.5419	None	gnomAD-4.0.0	1.6026E-06
8291	28	P/T	42	None	0.6017	None	gnomAD-4.0.0	1.60168E-06
8292	29	E/Q	43	rs778030351	0.8549	None	gnomAD-2.1.1	8.13E-06
8292	29	E/Q	43	rs778030351	0.8549	None	gnomAD-4.0.0	4.80143E-06
8294	31	R/G	45	rs72648982	0.8344	None	gnomAD-2.1.1	2.17258E-02
8294	31	R/G	45	rs72648982	0.8344	None	gnomAD-3.1.2	2.06025E-02
8294	31	R/G	45	rs72648982	0.8344	None	1000 genomes	1.21805E-02
8294	31	R/G	45	rs72648982	0.8344	None	gnomAD-4.0.0	2.73513E-02
8295	32	I/N	46	rs752786293	0.1745	None	gnomAD-2.1.1	8.09E-06
8295	32	I/N	46	rs752786293	0.1745	None	gnomAD-4.0.0	6.38857E-06
8296	33	S/P	47	None	0.1799	None	gnomAD-4.0.0	6.85202E-07
8296	33	S/T	47	rs767731986	0.1799	None	gnomAD-2.1.1	1.21E-05
8296	33	S/T	47	rs767731986	0.1799	None	gnomAD-3.1.2	6.57E-06
8296	33	S/T	47	rs767731986	0.1799	None	gnomAD-4.0.0	2.48203E-06
8297	34	W/C	48	rs727504205	0.1195	None	gnomAD-4.0.0	2.05508E-06
8299	36	K/E	50	rs2077774413	0.1768	None	gnomAD-3.1.2	6.57E-06
8299	36	K/E	50	rs2077774413	0.1768	None	gnomAD-4.0.0	6.57255E-06
8299	36	K/R	50	None	0.1768	None	gnomAD-4.0.0	1.36967E-06
8300	37	E/D	51	rs1438429191	0.6243	None	gnomAD-2.1.1	4.03E-06
8300	37	E/D	51	rs1438429191	0.6243	None	gnomAD-4.0.0	6.8472E-07
8300	37	E/K	51	rs1300968279	0.6243	None	gnomAD-3.1.2	6.58E-06
8300	37	E/K	51	rs1300968279	0.6243	None	gnomAD-4.0.0	6.57583E-06
8300	37	E/Q	51	rs1300968279	0.6243	None	gnomAD-2.1.1	4.03E-06
8300	37	E/Q	51	rs1300968279	0.6243	None	gnomAD-3.1.2	6.58E-06
8300	37	E/Q	51	rs1300968279	0.6243	None	gnomAD-4.0.0	5.13343E-06
8301	38	H/L	52	rs763397399	0.8512	None	gnomAD-2.1.1	4.03E-06
8301	38	H/L	52	rs763397399	0.8512	None	gnomAD-4.0.0	1.59372E-06
8301	38	H/N	52	rs375389220	0.8512	None	gnomAD-3.1.2	6.57E-06
8301	38	H/N	52	rs375389220	0.8512	None	1000 genomes	1.99681E-04
8301	38	H/N	52	rs375389220	0.8512	None	gnomAD-4.0.0	6.56901E-06
8301	38	H/Y	52	rs375389220	0.8512	None	gnomAD-2.1.1	4.03E-06
8301	38	H/Y	52	rs375389220	0.8512	None	gnomAD-4.0.0	2.05425E-06
8302	39	T/A	55	None	0.4148	None	gnomAD-4.0.0	6.84604E-07
8302	39	T/K	55	rs549604128	0.4148	None	gnomAD-2.1.1	8.94E-05
8302	39	T/K	55	rs549604128	0.4148	None	gnomAD-3.1.2	5.26E-05
8302	39	T/K	55	rs549604128	0.4148	None	1000 genomes	3.99361E-04
8302	39	T/K	55	rs549604128	0.4148	None	gnomAD-4.0.0	2.23197E-05
8302	39	T/S	55	None	0.4148	None	gnomAD-4.0.0	6.84604E-07
8305	42	R/Q	59	rs759985618	0.5338	None	gnomAD-2.1.1	5.23E-05
8305	42	R/Q	59	rs759985618	0.5338	None	gnomAD-3.1.2	6.58E-06
8305	42	R/Q	59	rs759985618	0.5338	None	gnomAD-4.0.0	3.34745E-05
8306	43	S/L	70	rs776712129	0.5712	None	gnomAD-2.1.1	4.02E-06
8306	43	S/L	70	rs776712129	0.5712	None	gnomAD-3.1.2	6.57E-06
8306	43	S/L	70	rs776712129	0.5712	None	gnomAD-4.0.0	1.36365E-05
8307	44	A/G	73	rs2077769834	0.3233	None	gnomAD-4.0.0	1.20032E-06
8308	45	P/S	102	rs373770383	0.8927	None	gnomAD-2.1.1	4.64E-05
8308	45	P/S	102	rs373770383	0.8927	None	gnomAD-3.1.2	1.38053E-04
8308	45	P/S	102	rs373770383	0.8927	None	gnomAD-4.0.0	2.23131E-05
8309	46	A/E	115	rs186598275	0.2881	None	gnomAD-2.1.1	4.02E-06
8309	46	A/E	115	rs186598275	0.2881	None	gnomAD-3.1.2	6.57E-06
8309	46	A/E	115	rs186598275	0.2881	None	gnomAD-4.0.0	6.5678E-06
8309	46	A/V	115	rs186598275	0.2881	None	gnomAD-2.1.1	4.02E-06
8309	46	A/V	115	rs186598275	0.2881	None	gnomAD-3.1.2	6.57E-06
8309	46	A/V	115	rs186598275	0.2881	None	gnomAD-4.0.0	6.5678E-06
8310	47	Y/C	121	rs879064808	0.2394	None	gnomAD-2.1.1	4.02E-06
8310	47	Y/C	121	rs879064808	0.2394	None	gnomAD-4.0.0	3.42137E-06
8310	47	Y/H	121	None	0.2394	None	gnomAD-4.0.0	6.84287E-07
8310	47	Y/N	121	rs397517511	0.2394	None	gnomAD-2.1.1	1.21E-05
8310	47	Y/N	121	rs397517511	0.2394	None	gnomAD-3.1.2	1.31E-05
8310	47	Y/N	121	rs397517511	0.2394	None	gnomAD-4.0.0	4.33831E-06
8311	48	K/N	122	rs749075617	0.5229	None	gnomAD-2.1.1	4.02E-06
8311	48	K/N	122	rs749075617	0.5229	None	gnomAD-4.0.0	1.59155E-06
8312	49	M/I	123	None	0.2664	None	gnomAD-4.0.0	1.59157E-06
8312	49	M/T	123	rs756314449	0.2664	None	gnomAD-2.1.1	4.02E-06
8312	49	M/T	123	rs756314449	0.2664	None	gnomAD-3.1.2	6.57E-06
8312	49	M/T	123	rs756314449	0.2664	None	gnomAD-4.0.0	5.12522E-06
8312	49	M/V	123	rs777456359	0.2664	None	gnomAD-2.1.1	4.02E-06
8312	49	M/V	123	rs777456359	0.2664	None	gnomAD-4.0.0	1.59155E-06
8314	51	F/L	127	rs570367600	0.2327	None	gnomAD-2.1.1	1.61E-05
8314	51	F/L	127	rs570367600	0.2327	None	gnomAD-3.1.2	6.57E-06
8314	51	F/L	127	rs570367600	0.2327	None	1000 genomes	1.99681E-04
8314	51	F/L	127	rs570367600	0.2327	None	gnomAD-4.0.0	1.11405E-05
8317	54	N/I	134	rs1278554973	0.5014	None	gnomAD-2.1.1	4.02E-06
8317	54	N/I	134	rs1278554973	0.5014	None	gnomAD-4.0.0	4.10542E-06
8317	54	N/K	134	rs370154022	0.5014	None	gnomAD-2.1.1	1.61E-05
8317	54	N/K	134	rs370154022	0.5014	None	gnomAD-3.1.2	7.89E-05
8317	54	N/K	134	rs370154022	0.5014	None	gnomAD-4.0.0	1.11553E-05
8318	55	V/I	135	rs200103997	0.1834	None	gnomAD-2.1.1	5.74659E-04
8318	55	V/I	135	rs200103997	0.1834	None	gnomAD-3.1.2	5.45572E-04
8318	55	V/I	135	rs200103997	0.1834	None	1000 genomes	1.99681E-04
8318	55	V/I	135	rs200103997	0.1834	None	gnomAD-4.0.0	7.49198E-04
8319	56	A/P	136	None	0.0930	None	gnomAD-4.0.0	4.80129E-06
8319	56	A/T	136	rs2077763797	0.0930	None	gnomAD-3.1.2	6.57E-06
8319	56	A/T	136	rs2077763797	0.0930	None	gnomAD-4.0.0	6.57263E-06
8319	56	A/V	136	None	0.0930	None	gnomAD-4.0.0	2.40064E-06
8320	57	S/C	137	rs1374151646	0.1446	None	gnomAD-3.1.2	1.31E-05
8320	57	S/C	137	rs1374151646	0.1446	None	gnomAD-4.0.0	1.31377E-05
8320	57	S/F	137	rs1374151646	0.1446	None	gnomAD-2.1.1	4.02E-06
8320	57	S/F	137	rs1374151646	0.1446	None	gnomAD-4.0.0	4.77415E-06
8322	59	V/A	139	None	0.2617	None	gnomAD-4.0.0	4.77412E-06
8322	59	V/I	139	rs201571580	0.2617	None	gnomAD-2.1.1	4.02E-06
8322	59	V/I	139	rs201571580	0.2617	None	gnomAD-4.0.0	6.84232E-07
8322	59	V/L	139	rs201571580	0.2617	None	gnomAD-2.1.1	5.88962E-04
8322	59	V/L	139	rs201571580	0.2617	None	gnomAD-3.1.2	4.86349E-04
8322	59	V/L	139	rs201571580	0.2617	None	gnomAD-4.0.0	6.38259E-04
8324	61	N/K	141	rs879030954	0.5461	None	gnomAD-4.0.0	4.10537E-06
8325	62	K/E	143	rs72648984	0.6672	None	gnomAD-2.1.1	5.58292E-03
8325	62	K/E	143	rs72648984	0.6672	None	gnomAD-3.1.2	4.66442E-03
8325	62	K/E	143	rs72648984	0.6672	None	1000 genomes	1.59744E-03
8325	62	K/E	143	rs72648984	0.6672	None	gnomAD-4.0.0	5.69265E-03
8325	62	K/N	143	rs373995644	0.6672	None	gnomAD-2.1.1	4.02E-06
8327	64	D/V	145	None	0.2791	None	gnomAD-4.0.0	1.5914E-06
8328	65	H/N	146	rs767212475	0.8645	None	gnomAD-2.1.1	4.02E-06
8329	66	S/G	148	None	0.5410	None	gnomAD-4.0.0	2.40064E-06
8329	66	S/N	148	None	0.5410	None	gnomAD-4.0.0	4.78965E-06
8330	67	D/H	149	None	0.1418	None	gnomAD-4.0.0	1.20032E-06
8331	68	V/E	151	rs773888026	0.2797	None	gnomAD-2.1.1	4.02E-06
8331	68	V/E	151	rs773888026	0.2797	None	gnomAD-4.0.0	1.20032E-06
8332	69	G/E	152	rs2077756630	0.2195	None	gnomAD-3.1.2	6.57E-06
8332	69	G/E	152	rs2077756630	0.2195	None	gnomAD-4.0.0	6.57212E-06
8333	70	E/D	153	rs1438182051	0.5040	None	gnomAD-2.1.1	3.18E-05
8333	70	E/D	153	rs1438182051	0.5040	None	gnomAD-3.1.2	6.57E-06
8333	70	E/D	153	rs1438182051	0.5040	None	gnomAD-4.0.0	2.56224E-06
8333	70	E/G	153	rs770811407	0.5040	None	gnomAD-2.1.1	4.02E-06
8333	70	E/G	153	rs770811407	0.5040	None	gnomAD-4.0.0	7.95689E-06
8335	72	S/A	155	rs773006091	0.2275	None	gnomAD-2.1.1	4.02E-06
8335	72	S/A	155	rs773006091	0.2275	None	gnomAD-4.0.0	6.84237E-07
8335	72	S/T	155	None	0.2275	None	gnomAD-4.0.0	6.84237E-07
8336	73	C/G	156	None	0.0714	None	gnomAD-4.0.0	1.20032E-06
8336	73	C/S	156	None	0.0714	None	gnomAD-4.0.0	1.20032E-06
8339	76	D/E	159	rs1283273345	0.3546	None	gnomAD-2.1.1	4.02E-06
8339	76	D/E	159	rs1283273345	0.3546	None	gnomAD-4.0.0	4.77458E-06
8340	77	N/S	161	None	0.1707	None	gnomAD-4.0.0	2.40064E-06
8341	78	S/R	162	rs1221926854	0.6272	None	gnomAD-2.1.1	4.02E-06
8341	78	S/R	162	rs1221926854	0.6272	None	gnomAD-4.0.0	6.84318E-07
8343	80	G/A	164	rs1288642142	0.2637	None	gnomAD-2.1.1	4.02E-06
8343	80	G/A	164	rs1288642142	0.2637	None	gnomAD-4.0.0	1.59204E-06
8344	81	A/E	165	rs748045267	0.3413	None	gnomAD-2.1.1	4.03E-06
8344	81	A/E	165	rs748045267	0.3413	None	gnomAD-4.0.0	1.59253E-06
8344	81	A/T	165	rs2077751372	0.3413	None	gnomAD-4.0.0	1.36876E-06
8345	82	V/A	166	None	0.1191	None	gnomAD-4.0.0	6.37397E-06
8346	83	A/T	168	rs755302381	0.2884	None	gnomAD-2.1.1	2.01E-05
8346	83	A/T	168	rs755302381	0.2884	None	gnomAD-3.1.2	1.31E-05
8346	83	A/T	168	rs755302381	0.2884	None	gnomAD-4.0.0	8.06179E-06
8346	83	A/V	168	rs747055472	0.2884	None	gnomAD-2.1.1	4.03E-06
8346	83	A/V	168	rs747055472	0.2884	None	gnomAD-4.0.0	1.5941E-06
8347	84	S/P	169	rs1345180729	0.1278	None	gnomAD-2.1.1	4.03E-06
8347	84	S/P	169	rs1345180729	0.1278	None	gnomAD-4.0.0	1.59401E-06
8349	86	A/G	172	rs397517513	0.0950	None	gnomAD-2.1.1	1.79E-05
8349	86	A/G	172	rs397517513	0.0950	None	gnomAD-3.1.2	1.97E-05
8349	86	A/G	172	rs397517513	0.0950	None	gnomAD-4.0.0	3.597E-05
8349	86	A/P	172	rs1459194268	0.0950	None	gnomAD-2.1.1	4.03E-06
8349	86	A/P	172	rs1459194268	0.0950	None	gnomAD-4.0.0	1.59459E-06
8349	86	A/V	172	rs397517513	0.0950	None	gnomAD-3.1.2	1.97E-05
8349	86	A/V	172	rs397517513	0.0950	None	gnomAD-4.0.0	1.9714E-05
8350	87	V/A	173	rs915984764	0.1905	None	gnomAD-4.0.0	2.0553E-06
8350	87	V/M	173	None	0.1905	None	gnomAD-3.1.2	6.57E-06
8350	87	V/M	173	None	0.1905	None	gnomAD-4.0.0	6.5722E-06
8352	89	V/L	175	rs750897859	0.3289	None	gnomAD-2.1.1	4.04E-06
8352	89	V/L	175	rs750897859	0.3289	None	gnomAD-4.0.0	9.58653E-06
8353	90	I/N	177	None	1.0303	None	gnomAD-4.0.0	1.59872E-06
8353	90	I/V	177	None	1.0303	None	gnomAD-4.0.0	1.37112E-06

Position	Domain position	SAV	RS	Q(SASA)	Source	Structural Position	Disease	AlphaMissense (IC)	AlphaMissense (N2AB)	CADD	Condel	DUET	FATHMM	M-CAP	mCSM	MetaLR	MetaSVM	MPC	MutationAssessor	MutationTaster	MutPred	MVP	PolyPhen-2	PrimateAI	PROVEAN	REVEL	Rhapsody	SIFT	Zygosity	Comments	MAF	AFR	AMR	AMS	ASJ	EAS	EUR	FIN	MDE	NFE	SAS	OTH	Site Annotation	Predicted PPI	mCSM-PPI
8264	1	P/A	None	0.1540	gnomAD-4.0.0	1	None	0.7427	0.9062	23.7	D	None	-1.42	0.033814	-1.683	0.8845	0.9625	0.457628982806	None	0.955088	0.671	0.74833783201	1.0	0.557604074478	-4.6	0.638	0.818	0.126	None	None	1.63066E-06	0	0	4.84496E-05	0	None	0	0	1.63066E-06	0	0	0	None	N	None
8264	1	P/L	rs1235369035	0.1540	gnomAD-2.1.1	1	None	0.9327	0.9746	31.0	D	0.033	-1.44	0.058157	-0.55	0.8845	0.9625	0.469722267271	None	0.999996	0.704	0.905832655978	1.0	0.624692499638	-6.29	0.647	0.865	0.026	None	None	8.38E-06	0	0	0	0	None	3.42E-05	None	8.38E-06	0	9.02E-06	0	None	N	None
8264	1	P/L	rs1235369035	0.1540	gnomAD-4.0.0	1	None	0.9327	0.9746	31.0	D	0.033	-1.44	0.058157	-0.55	0.8845	0.9625	0.469722267271	None	0.999996	0.704	0.905832655978	1.0	0.624692499638	-6.29	0.647	0.865	0.026	None	None	4.14748E-06	0	0	0	0	None	0	0	4.14748E-06	2.70866E-06	2.34775E-05	1.66706E-05	None	N	None
8265	2	Y/N	None	0.4846	gnomAD-4.0.0	2	None	0.3341	0.3739	23.7	N	None	-0.2	0.032736	-1.108	0.3109	-0.4377	0.492194612246	None	1.0	0.531	0.554721145582	0.997	0.579746127129	-4.49	0.306	0.552	0.298	None	None	1.6283E-06	0	0	0	0	None	0	0	1.6283E-06	2.89039E-06	0	0	None	N	None
8266	3	F/Y	rs768252647	0.1707	gnomAD-2.1.1	3	None	0.6969	0.7482	26.3	D	-1.033	-0.71	0.044807	-0.727	0.6964	0.7164	0.468642469395	None	0.512406	0.706	0.851514812675	0.999	0.688549697399	-1.96	0.623	0.657	0.022	None	None	8.33E-06	0	0	0	0	None	0	None	8.33E-06	0	1.8E-05	0	None	N	None
8266	3	F/Y	rs768252647	0.1707	gnomAD-4.0.0	3	None	0.6969	0.7482	26.3	D	-1.033	-0.71	0.044807	-0.727	0.6964	0.7164	0.468642469395	None	0.512406	0.706	0.851514812675	0.999	0.688549697399	-1.96	0.623	0.657	0.022	None	None	1.78772E-05	0	0	0	0	None	2.2172E-05	0	1.78772E-05	2.5959E-05	0	3.05045E-05	None	N	None
8267	4	I/F	rs534974639	0.6069	gnomAD-2.1.1	4	None	0.2149	0.2277	22.4	N	-0.791	0.98	0.01551	-0.988	0.1232	-0.8958	0.182198156154	None	1.0	0.477	0.446510307777	0.453	0.352587968111	-2.48	0.189	0.281	0.034	None	None	8.33E-06	1.29938E-04	0	0	0	None	0	None	8.33E-06	0	0	0	None	N	None
8267	4	I/F	rs534974639	0.6069	gnomAD-3.1.2	4	None	0.2149	0.2277	22.4	N	-0.791	0.98	0.01551	-0.988	0.1232	-0.8958	0.182198156154	None	1.0	0.477	0.446510307777	0.453	0.352587968111	-2.48	0.189	0.281	0.034	None	None	1.97E-05	7.24E-05	0	0	0	None	0	0	1.97E-05	0	0	0	None	N	None
8267	4	I/F	rs534974639	0.6069	1000 genomes	4	None	0.2149	0.2277	22.4	N	-0.791	0.98	0.01551	-0.988	0.1232	-0.8958	0.182198156154	None	1.0	0.477	0.446510307777	0.453	0.352587968111	-2.48	0.189	0.281	0.034	None	None	3.99361E-04	1.5E-03	0	None	0	0	None	None	3.99361E-04	None	0	None	None	N	None
8267	4	I/F	rs534974639	0.6069	gnomAD-4.0.0	4	None	0.2149	0.2277	22.4	N	-0.791	0.98	0.01551	-0.988	0.1232	-0.8958	0.182198156154	None	1.0	0.477	0.446510307777	0.453	0.352587968111	-2.48	0.189	0.281	0.034	None	None	6.87145E-06	1.47035E-04	0	0	0	None	0	0	6.87145E-06	0	0	0	None	N	None
8267	4	I/T	None	0.6069	gnomAD-4.0.0	4	None	0.0884	0.0889	22.1	N	None	0.97	0.012188	-1.488	0.0644	-1.0191	0.108341744055	None	1.0	0.459	0.359357374593	0.002	0.420844912529	-2.66	0.073	0.109	0.205	None	None	1.62361E-06	0	0	0	0	None	0	0	1.62361E-06	0	1.44513E-05	0	None	N	None
8269	6	P/L	rs960099770	0.4535	gnomAD-4.0.0	7	None	0.1476	0.1668	None	N	None	None	None	-0.441	None	None	None	None	None	None	None	0.011	None	None	0.239	0.412	None	None	None	1.62141E-06	0	0	0	0	None	0	0	1.62141E-06	0	0	3.04507E-05	None	N	None
8271	8	E/K	None	0.7731	gnomAD-4.0.0	9	None	0.0827	0.0927	23.0	N	None	-0.09	0.054923	0.012	0.1795	-0.8811	0.0953457349355	None	0.978374	0.551	0.260249123532	0.002	0.422845244408	-1.7	0.174	0.192	0.015	None	None	4.13603E-06	0	0	0	0	None	0	0	4.13603E-06	0	4.65452E-05	3.32303E-05	None	I	None
8271	8	E/Q	None	0.7731	gnomAD-4.0.0	9	None	0.0795	0.0853	22.6	N	None	-0.22	0.04124	-0.185	0.2068	-0.8263	0.0826069907463	None	1.0	0.46	0.264547087235	None	0.362647891045	-1.34	0.106	0.173	0.412	None	None	6.89338E-07	0	0	0	0	None	0	0	6.89338E-07	0	1.16363E-05	0	None	I	None
8272	9	H/L	None	0.6108	gnomAD-4.0.0	11	None	0.1173	0.1229	22.7	N	None	1.05	0.019211	0.936	0.1141	-0.9427	0.106932719672	None	1.0	0.512	0.434825671192	0.085	0.414362639189	-5.22	0.279	0.223	0.397	None	None	6.88821E-07	0	0	0	0	None	0	0	6.88821E-07	9.00341E-07	0	0	None	N	None
8272	9	H/P	rs1299797032	0.6108	gnomAD-2.1.1	11	None	0.0593	0.0613	22.7	N	0.423	1.11	0.012296	0.749	0.0774	-0.9897	0.133093384471	None	1.0	0.474	0.264081493735	None	0.409556746483	-4.32	0.277	0.081	0.252	None	None	4.13E-06	0	0	0	0	None	0	None	4.13E-06	0	8.92E-06	0	None	N	None
8272	9	H/P	rs1299797032	0.6108	gnomAD-4.0.0	11	None	0.0593	0.0613	22.7	N	0.423	1.11	0.012296	0.749	0.0774	-0.9897	0.133093384471	None	1.0	0.474	0.264081493735	None	0.409556746483	-4.32	0.277	0.081	0.252	None	None	1.37764E-06	0	0	0	0	None	0	0	1.37764E-06	1.80068E-06	0	0	None	N	None
8272	9	H/Q	None	0.6108	gnomAD-4.0.0	11	None	0.1327	0.1323	17.18	N	None	1.04	0.014801	0.163	0.1188	-0.9819	0.10760311356	None	1.0	0.439	0.115124310173	0.519	0.417504787445	-3.41	0.131	0.251	0.548	None	None	1.61603E-06	0	0	0	0	None	0	0	1.61603E-06	2.86627E-06	0	0	None	N	None
8272	9	H/Y	None	0.6108	gnomAD-4.0.0	11	None	0.1151	0.1042	22.0	N	None	1.03	0.011443	1.132	0.21	-0.6516	0.19388941855	None	1.0	0.461	0.302793454619	0.899	0.438545286655	-2.79	0.247	0.313	0.36	None	None	2.068E-06	0	0	0	0	None	0	0	2.068E-06	2.7024E-06	0	0	None	N	None
8273	10	V/A	None	0.2964	gnomAD-4.0.0	13	None	0.1606	0.1582	22.6	D	None	-0.47	0.033605	-1.216	0.2797	-0.7267	0.102023578772	None	1.0	0.591	0.498705051145	0.002	0.330527514219	-1.97	0.177	0.103	0.061	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
8273	10	V/M	None	0.2964	gnomAD-4.0.0	13	None	0.119	0.1108	15.91	N	None	-0.53	0.02745	-0.434	0.2781	-0.7116	0.0845876680236	None	1.0	0.535	0.183819452728	0.005	0.323266029358	-1.46	0.134	0.265	0.014	None	None	1.61611E-06	0	2.29474E-05	0	0	None	0	0	1.61611E-06	0	0	0	None	N	None
8274	11	E/K	rs72648981	0.8341	gnomAD-2.1.1	14	None	0.1874	0.2075	None	N	0.792	None	None	0.211	None	None	None	None	None	None	None	0.967	None	None	0.248	0.604	None	None	None	2.30508E-03	4.97471E-04	7.95635E-04	1.16822E-03	0	None	0	None	2.30508E-03	4.02228E-03	3.75627E-03	2.9855E-03	None	I	None
8274	11	E/K	rs72648981	0.8341	gnomAD-3.1.2	14	None	0.1874	0.2075	None	N	0.792	None	None	0.211	None	None	None	None	None	None	None	0.967	None	None	0.248	0.604	None	None	None	2.32668E-03	6.75774E-04	1.17878E-03	5.76701E-04	0	None	3.9548E-03	0	2.32668E-03	3.82241E-03	0	1.91022E-03	None	I	None
8274	11	E/K	rs72648981	0.8341	1000 genomes	14	None	0.1874	0.2075	None	N	0.792	None	None	0.211	None	None	None	None	None	None	None	0.967	None	None	0.248	0.604	None	None	None	5.99042E-04	0	0	None	0	3E-03	None	None	5.99042E-04	None	0	None	None	I	None
8274	11	E/K	rs72648981	0.8341	gnomAD-4.0.0	14	None	0.1874	0.2075	None	N	0.792	None	None	0.211	None	None	None	None	None	None	None	0.967	None	None	0.248	0.604	None	None	None	2.97975E-03	5.33988E-04	8.52016E-04	8.12623E-04	0	None	3.21302E-03	0	2.97975E-03	3.69014E-03	0	2.16485E-03	None	I	None
8275	12	A/T	rs771947778	0.2881	gnomAD-2.1.1	16	None	0.0954	0.0888	22.7	N	-1.281	-0.37	0.028954	-1.421	0.246	-0.7921	0.0836914353772	None	1.0	0.509	0.300449992093	0.01	0.40818721056	-1.77	0.216	0.149	0.446	None	None	4.13E-06	0	0	0	0	None	3.29E-05	None	4.13E-06	0	0	0	None	I	None
8275	12	A/T	rs771947778	0.2881	gnomAD-4.0.0	16	None	0.0954	0.0888	22.7	N	-1.281	-0.37	0.028954	-1.421	0.246	-0.7921	0.0836914353772	None	1.0	0.509	0.300449992093	0.01	0.40818721056	-1.77	0.216	0.149	0.446	None	None	1.10167E-05	0	0	0	0	None	0	0	1.10167E-05	1.17018E-05	3.48554E-05	0	None	I	None
8277	14	I/T	rs745818162	0.7584	gnomAD-2.1.1	23	None	0.0905	0.089	21.2	N	-0.48	1.01	0.018545	-1.018	0.2518	-0.704	0.134568626628	None	1.0	0.523	0.527404433557	0.074	0.367490887642	-2.14	0.135	0.383	0.527	None	None	1.1E-05	0	0	0	5.14E-05	None	0	None	1.1E-05	5.09E-05	7.83E-06	0	None	I	None
8277	14	I/T	rs745818162	0.7584	gnomAD-3.1.2	23	None	0.0905	0.089	21.2	N	-0.48	1.01	0.018545	-1.018	0.2518	-0.704	0.134568626628	None	1.0	0.523	0.527404433557	0.074	0.367490887642	-2.14	0.135	0.383	0.527	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	0	2.07039E-04	0	None	I	None
8277	14	I/T	rs745818162	0.7584	gnomAD-4.0.0	23	None	0.0905	0.089	21.2	N	-0.48	1.01	0.018545	-1.018	0.2518	-0.704	0.134568626628	None	1.0	0.523	0.527404433557	0.074	0.367490887642	-2.14	0.135	0.383	0.527	None	None	7.7693E-06	0	0	0	7.27237E-05	None	0	0	7.7693E-06	2.39584E-06	1.3416E-05	2.85063E-05	None	I	None
8278	15	G/A	rs778611558	0.2506	gnomAD-2.1.1	24	None	0.4602	0.5819	23.1	D	-0.587	-1.47	0.058669	-0.42	0.5916	0.4251	0.144621419513	None	0.527796	0.875	0.528959857459	0.896	0.470357507467	-4.08	0.55	0.342	0.013	None	None	4.75E-05	0	3.68794E-04	0	0	None	0	None	4.75E-05	0	0	0	None	I	None
8278	15	G/A	rs778611558	0.2506	gnomAD-3.1.2	24	None	0.4602	0.5819	23.1	D	-0.587	-1.47	0.058669	-0.42	0.5916	0.4251	0.144621419513	None	0.527796	0.875	0.528959857459	0.896	0.470357507467	-4.08	0.55	0.342	0.013	None	None	3.29E-05	0	3.27397E-04	0	0	None	0	0	3.29E-05	0	0	0	None	I	None
8278	15	G/A	rs778611558	0.2506	gnomAD-4.0.0	24	None	0.4602	0.5819	23.1	D	-0.587	-1.47	0.058669	-0.42	0.5916	0.4251	0.144621419513	None	0.527796	0.875	0.528959857459	0.896	0.470357507467	-4.08	0.55	0.342	0.013	None	None	3.36686E-05	0	3.39282E-04	0	0	None	0	2.24316E-04	3.36686E-05	4.79138E-06	0	8.55334E-05	None	I	None
8278	15	G/R	rs1406754899	0.2506	gnomAD-2.1.1	24	None	0.6194	0.7818	23.8	D	-0.726	-1.48	0.040137	-0.633	0.7725	0.6761	0.489325189415	None	0.645136	0.869	0.871362720137	1.0	0.540491461754	-5.35	0.596	0.811	0.082	None	None	4.12E-06	0	0	0	5.58E-05	None	0	None	4.12E-06	0	0	0	None	I	None
8278	15	G/R	rs1406754899	0.2506	gnomAD-4.0.0	24	None	0.6194	0.7818	23.8	D	-0.726	-1.48	0.040137	-0.633	0.7725	0.6761	0.489325189415	None	0.645136	0.869	0.871362720137	1.0	0.540491461754	-5.35	0.596	0.811	0.082	None	None	1.6128E-06	0	0	0	2.77346E-05	None	0	0	1.6128E-06	0	0	0	None	I	None
8280	17	P/L	rs375219172	0.4169	gnomAD-2.1.1	26	None	0.1175	0.1265	None	N	-0.294	None	None	-0.489	None	None	None	None	None	None	None	0.44	None	None	0.335	0.457	None	None	None	8.23E-06	0	0	0	0	None	0	None	8.23E-06	0	1.78E-05	0	None	I	None
8280	17	P/L	rs375219172	0.4169	gnomAD-3.1.2	26	None	0.1175	0.1265	None	N	-0.294	None	None	-0.489	None	None	None	None	None	None	None	0.44	None	None	0.335	0.457	None	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
8280	17	P/L	rs375219172	0.4169	gnomAD-4.0.0	26	None	0.1175	0.1265	None	N	-0.294	None	None	-0.489	None	None	None	None	None	None	None	0.44	None	None	0.335	0.457	None	None	None	8.09428E-06	0	0	0	0	None	0	0	8.09428E-06	1.10216E-05	0	0	None	I	None
8280	17	P/R	rs375219172	0.4169	gnomAD-3.1.2	26	None	0.1633	0.1933	22.3	N	None	0.98	0.019638	-0.074	0.1977	-0.732	0.177318391536	None	1.0	0.519	0.518752145996	0.734	0.353062361479	-4.16	0.384	0.463	0.007	None	None	1.31E-05	0	0	0	0	None	0	0	1.31E-05	2.94E-05	0	0	None	I	None
8280	17	P/R	rs375219172	0.4169	gnomAD-4.0.0	26	None	0.1633	0.1933	22.3	N	None	0.98	0.019638	-0.074	0.1977	-0.732	0.177318391536	None	1.0	0.519	0.518752145996	0.734	0.353062361479	-4.16	0.384	0.463	0.007	None	None	1.86791E-06	0	0	0	0	None	0	0	1.86791E-06	2.54345E-06	0	0	None	I	None
8281	18	A/E	rs1474165122	0.2053	gnomAD-2.1.1	28	None	0.5176	0.6234	15.42	D	-1.112	0.8	0.035825	-0.937	0.4483	-0.4644	0.126849110582	None	1.0	0.695	0.186928172975	0.055	0.219802707434	-2.26	0.374	0.689	0.335	None	None	8.22E-06	0	0	0	0	None	6.55E-05	None	8.22E-06	0	0	0	None	I	None
8281	18	A/E	rs1474165122	0.2053	gnomAD-4.0.0	28	None	0.5176	0.6234	15.42	D	-1.112	0.8	0.035825	-0.937	0.4483	-0.4644	0.126849110582	None	1.0	0.695	0.186928172975	0.055	0.219802707434	-2.26	0.374	0.689	0.335	None	None	4.83065E-06	0	0	0	0	None	0	0	4.83065E-06	0	4.30108E-05	0	None	I	None
8281	18	A/T	rs2077783832	0.2053	gnomAD-4.0.0	28	None	0.076	0.0736	8.798	N	None	0.83	0.073113	-1.233	0.2605	-0.8348	0.0809002040292	None	1.0	0.617	0.0401082797425	None	0.217432081699	-0.28	0.211	0.183	0.606	None	None	1.61075E-06	0	0	0	0	None	0	0	1.61075E-06	2.86054E-06	0	0	None	I	None
8282	19	T/A	rs2077783131	0.6361	gnomAD-4.0.0	29	None	0.0839	0.0892	19.13	D	None	0.83	0.029126	-0.539	0.2666	-0.5169	0.0825183256142	None	0.807708	0.449	0.202949470691	0.002	0.361843585968	-2.76	0.234	0.302	0.412	None	None	4.80129E-06	0	0	0	0	None	0	0	4.80129E-06	5.25001E-06	0	0	None	I	None
8282	19	T/I	None	0.6361	gnomAD-4.0.0	29	None	0.0992	0.0874	21.0	N	None	0.88	0.012635	-0.016	0.2405	-0.5554	0.115736447682	None	0.999993	0.471	0.452264262256	0.685	0.432209849358	-3.55	0.232	0.507	0.218	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
8283	20	L/F	rs1454021604	0.1370	gnomAD-3.1.2	30	None	0.1026	0.0831	21.2	D	None	-0.29	0.039151	-1.427	0.2848	-0.6518	0.124771192803	None	1.0	0.6	0.328222422547	0.429	0.497684657574	-2.3	0.465	0.333	0.463	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
8283	20	L/F	rs1454021604	0.1370	gnomAD-4.0.0	30	None	0.1026	0.0831	21.2	D	None	-0.29	0.039151	-1.427	0.2848	-0.6518	0.124771192803	None	1.0	0.6	0.328222422547	0.429	0.497684657574	-2.3	0.465	0.333	0.463	None	None	3.73346E-06	0	0	0	0	None	0	0	3.73346E-06	5.08646E-06	0	0	None	N	None
8283	20	L/V	rs1408912599	0.1370	gnomAD-3.1.2	30	None	0.2984	0.315	23.1	D	None	-0.89	0.02739	-1.259	0.6953	0.6045	0.33086531146	None	1.0	0.753	0.738333703548	0.959	0.468294322491	-2.1	0.64	0.663	0.123	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
8283	20	L/V	rs1408912599	0.1370	gnomAD-4.0.0	30	None	0.2984	0.315	23.1	D	None	-0.89	0.02739	-1.259	0.6953	0.6045	0.33086531146	None	1.0	0.753	0.738333703548	0.959	0.468294322491	-2.1	0.64	0.663	0.123	None	None	6.57151E-06	2.41266E-05	0	0	0	None	0	0	6.57151E-06	0	0	0	None	N	None
8284	21	Q/E	None	0.4974	gnomAD-4.0.0	31	None	0.106	0.1042	20.9	N	None	-0.14	0.009263	-0.299	0.1091	-0.9658	0.0906360963538	None	1.0	0.513	0.188950314367	0.001	0.351324856281	-1.13	0.164	0.229	0.672	None	None	2.40066E-06	0	0	0	0	None	0	0	2.40066E-06	2.62502E-06	0	0	None	N	None
8284	21	Q/L	None	0.4974	gnomAD-4.0.0	31	None	0.1494	0.1359	22.6	N	None	-0.29	0.048625	0.248	0.183	-0.8822	0.0925630783963	None	1.0	0.51	0.442054744378	0.269	0.340373188257	-3.96	0.209	0.514	0.062	None	None	3.21576E-06	0	0	0	0	None	0	0	3.21576E-06	5.71948E-06	0	0	None	N	None
8285	22	C/G	rs757040162	0.0981	gnomAD-2.1.1	33	None	0.6744	0.7652	28.0	D	-2.511	-0.01	0.049816	-1.91	0.777	0.7934	0.516134083605	None	0.998195	0.858	0.933987002762	1.0	0.748343348503	-7.79	0.82	0.897	0.01	None	None	4.1E-06	0	2.9E-05	0	0	None	0	None	4.1E-06	0	0	0	disulfide	N	None
8285	22	C/R	None	0.0981	gnomAD-4.0.0	33	None	0.9938	0.9961	28.4	D	None	-0.02	0.133385	-1.561	0.8114	0.9163	0.61613149071	None	1.0	0.882	0.928824428499	1.0	0.81182962656	-7.85	0.84	0.927	0.001	None	None	6.87163E-07	0	0	0	0	None	0	0	6.87163E-07	8.99601E-07	0	0	disulfide	N	None
8285	22	C/S	rs757040162	0.0981	gnomAD-2.1.1	33	None	0.9243	0.9297	27.0	D	-2.348	-0.01	0.070135	-2.043	0.8114	0.9163	0.511892525395	None	0.996685	0.784	0.882702632475	1.0	0.76467692852	-6.32	0.839	0.83	0.009	None	None	4.1E-06	0	0	0	5.58E-05	None	0	None	4.1E-06	0	0	0	disulfide	N	None
8285	22	C/S	rs757040162	0.0981	gnomAD-4.0.0	33	None	0.9243	0.9297	27.0	D	-2.348	-0.01	0.070135	-2.043	0.8114	0.9163	0.511892525395	None	0.996685	0.784	0.882702632475	1.0	0.76467692852	-6.32	0.839	0.83	0.009	None	None	1.37433E-06	0	0	0	5.03956E-05	None	0	0	1.37433E-06	0	0	0	disulfide	N	None
8286	23	K/E	rs1454054276	0.3835	gnomAD-2.1.1	34	None	0.1793	0.1928	24.2	N	-0.78	-0.25	0.025329	-0.764	0.1754	-0.8148	0.13102085016	None	1.0	0.619	0.236278675362	0.114	0.395300805569	-1.64	0.158	0.456	0.681	None	None	4.1E-06	0	0	0	0	None	0	None	4.1E-06	0	8.9E-06	0	None	N	None
8286	23	K/E	rs1454054276	0.3835	gnomAD-4.0.0	34	None	0.1793	0.1928	24.2	N	-0.78	-0.25	0.025329	-0.764	0.1754	-0.8148	0.13102085016	None	1.0	0.619	0.236278675362	0.114	0.395300805569	-1.64	0.158	0.456	0.681	None	None	3.50342E-05	0	0	0	0	None	0	0	3.50342E-05	4.40793E-05	0	3.31543E-05	None	N	None
8286	23	K/Q	rs1454054276	0.3835	gnomAD-4.0.0	34	None	0.1235	0.1206	24.0	N	None	-0.27	0.017195	-1.19	0.1863	-0.8189	0.0895599370888	None	1.0	0.599	0.141422826196	None	0.366756379604	-1.54	0.106	0.173	0.274	None	None	1.37389E-06	0	0	0	0	None	0	0	1.37389E-06	0	0	3.31543E-05	None	N	None
8286	23	K/R	None	0.3835	gnomAD-4.0.0	34	None	0.0839	0.0822	23.2	N	None	-0.29	0.019424	-1.185	0.2445	-0.7512	0.0700097199672	None	1.0	0.557	0.219573609325	0.001	0.362001776695	-1.62	0.167	0.298	0.386	None	None	6.86896E-07	0	0	0	0	None	0	0	6.86896E-07	8.99557E-07	0	0	None	N	None
8287	24	V/A	rs2077779717	0.1183	gnomAD-4.0.0	35	None	0.7417	0.7617	24.2	N	None	-0.76	0.018757	-2.388	0.3325	-0.3233	0.308125847459	None	1.0	0.664	0.631562779424	0.95	0.533200085163	-2.41	0.485	0.673	0.012	None	None	1.60527E-06	0	0	0	0	None	0	0	1.60527E-06	2.85909E-06	0	0	None	N	None
8288	25	D/G	None	0.3627	gnomAD-4.0.0	38	None	0.1491	0.1311	23.4	N	None	-0.26	0.020468	-0.385	0.1468	-0.8789	0.110909846299	None	1.0	0.603	0.183819452728	None	0.378821253777	-2.79	0.237	0.127	0.311	None	None	1.20033E-06	6.33473E-05	0	0	0	None	0	0	1.20033E-06	0	0	0	None	I	None
8288	25	D/N	rs372538009	0.3627	gnomAD-3.1.2	38	None	0.108	0.1054	None	N	None	None	None	-0.67	None	None	None	None	None	None	None	0.042	None	None	0.172	0.264	None	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	I	None
8288	25	D/N	rs372538009	0.3627	gnomAD-4.0.0	38	None	0.108	0.1054	None	N	None	None	None	-0.67	None	None	None	None	None	None	None	0.042	None	None	0.172	0.264	None	None	None	2.57995E-06	3.38432E-05	0	0	0	None	0	0	2.57995E-06	0	0	0	None	I	None
8290	27	T/N	None	0.5419	gnomAD-4.0.0	41	None	0.1662	0.1816	25.0	N	None	-0.24	0.010887	-0.154	0.3255	-0.432	0.378630527484	None	1.0	0.481	0.521015664611	0.969	0.496015220881	-2.69	0.274	0.464	0.043	None	None	1.6026E-06	0	0	0	0	None	0	0	1.6026E-06	0	1.43303E-05	0	None	I	None
8291	28	P/T	None	0.6017	gnomAD-4.0.0	42	None	0.8405	0.9288	23.3	D	None	-0.83	0.029936	-0.599	0.7084	0.5917	0.435848555408	None	0.831968	0.812	0.761910172549	0.992	0.632291615009	-4.58	0.576	0.714	0.017	None	None	1.60168E-06	0	0	0	0	None	2.03252E-05	0	1.60168E-06	0	0	0	None	I	None
8292	29	E/Q	rs778030351	0.8549	gnomAD-2.1.1	43	None	0.3015	0.314	23.0	N	0.355	-0.25	0.015133	0.015	0.3913	-0.3159	0.399655812152	None	0.574281	0.555	0.342865806769	0.995	0.537032723427	-1.59	0.317	0.555	0.144	None	None	8.13E-06	0	0	0	0	None	3.27E-05	None	8.13E-06	0	8.9E-06	0	None	I	None
8292	29	E/Q	rs778030351	0.8549	gnomAD-4.0.0	43	None	0.3015	0.314	23.0	N	0.355	-0.25	0.015133	0.015	0.3913	-0.3159	0.399655812152	None	0.574281	0.555	0.342865806769	0.995	0.537032723427	-1.59	0.317	0.555	0.144	None	None	4.80143E-06	0	2.28676E-05	0	0	None	0	0	4.80143E-06	2.85902E-06	1.43291E-05	0	None	I	None
8294	31	R/G	rs72648982	0.8344	gnomAD-2.1.1	45	None	0.2614	0.2215	None	N	-0.125	None	None	-0.759	None	None	None	None	None	None	None	0.153	None	None	0.182	0.552	None	None	None	2.17258E-02	5.83368E-03	1.12633E-02	5.20309E-02	0	None	1.77859E-02	None	2.17258E-02	1.87732E-02	2.9633E-02	2.76134E-02	None	I	None
8294	31	R/G	rs72648982	0.8344	gnomAD-3.1.2	45	None	0.2614	0.2215	None	N	-0.125	None	None	-0.759	None	None	None	None	None	None	None	0.153	None	None	0.182	0.552	None	None	None	2.06025E-02	5.4298E-03	2.14772E-02	5.07205E-02	1.92604E-04	None	1.66604E-02	3.48101E-02	2.06025E-02	2.98018E-02	1.82119E-02	3.15186E-02	None	I	None
8294	31	R/G	rs72648982	0.8344	1000 genomes	45	None	0.2614	0.2215	None	N	-0.125	None	None	-0.759	None	None	None	None	None	None	None	0.153	None	None	0.182	0.552	None	None	None	1.21805E-02	2.3E-03	1.3E-02	None	1E-03	2.78E-02	None	None	1.21805E-02	None	2.04E-02	None	None	I	None
8294	31	R/G	rs72648982	0.8344	gnomAD-4.0.0	45	None	0.2614	0.2215	None	N	-0.125	None	None	-0.759	None	None	None	None	None	None	None	0.153	None	None	0.182	0.552	None	None	None	2.73513E-02	5.43855E-03	1.49485E-02	5.41326E-02	1.11428E-04	None	1.91762E-02	5.18494E-02	2.73513E-02	3.05717E-02	1.88524E-02	2.95097E-02	None	I	None
8295	32	I/N	rs752786293	0.1745	gnomAD-2.1.1	46	None	0.9307	0.9586	23.9	D	-1.373	-0.66	0.062118	-1.502	0.476	0.1276	0.360025565734	None	1.0	0.749	0.899350334792	0.965	0.706817984581	-4.5	0.658	0.845	0.001	None	None	8.09E-06	0	0	0	0	None	6.54E-05	None	8.09E-06	0	0	0	None	N	None
8295	32	I/N	rs752786293	0.1745	gnomAD-4.0.0	46	None	0.9307	0.9586	23.9	D	-1.373	-0.66	0.062118	-1.502	0.476	0.1276	0.360025565734	None	1.0	0.749	0.899350334792	0.965	0.706817984581	-4.5	0.658	0.845	0.001	None	None	6.38857E-06	0	0	0	0	None	0	0	6.38857E-06	0	5.73197E-05	0	None	N	None
8296	33	S/P	None	0.1799	gnomAD-4.0.0	47	None	0.9608	0.9889	21.9	D	None	-0.5	0.028089	0.038	0.4904	-0.112	0.161888323476	None	1.0	0.677	0.305086939656	0.117	0.535764753819	-2.77	0.527	0.588	0.095	None	None	6.85202E-07	0	0	0	0	None	0	0	6.85202E-07	8.99535E-07	0	0	None	N	None
8296	33	S/T	rs767731986	0.1799	gnomAD-2.1.1	47	None	0.1114	0.1228	20.6	N	-0.34	-0.37	0.013707	-0.719	0.1611	-0.9447	0.0777696191278	None	1.0	0.587	0.149567049428	0.001	0.526512026787	-1.25	0.091	0.248	0.921	None	None	1.21E-05	0	8.7E-05	0	0	None	0	None	1.21E-05	0	0	0	None	N	None
8296	33	S/T	rs767731986	0.1799	gnomAD-3.1.2	47	None	0.1114	0.1228	20.6	N	-0.34	-0.37	0.013707	-0.719	0.1611	-0.9447	0.0777696191278	None	1.0	0.587	0.149567049428	0.001	0.526512026787	-1.25	0.091	0.248	0.921	None	None	6.57E-06	0	6.55E-05	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
8296	33	S/T	rs767731986	0.1799	gnomAD-4.0.0	47	None	0.1114	0.1228	20.6	N	-0.34	-0.37	0.013707	-0.719	0.1611	-0.9447	0.0777696191278	None	1.0	0.587	0.149567049428	0.001	0.526512026787	-1.25	0.091	0.248	0.921	None	None	2.48203E-06	0	6.66756E-05	0	0	None	0	0	2.48203E-06	0	0	0	None	N	None
8297	34	W/C	rs727504205	0.1195	gnomAD-4.0.0	48	None	0.9969	0.9986	27.4	D	None	-3.97	0.644042	-1.643	0.9725	1.0599	0.580823813372	None	1.0	0.896	0.930896607594	1.0	0.843386530876	-9.2	0.788	0.871	None	None	None	2.05508E-06	0	0	0	0	None	0	0	2.05508E-06	2.69859E-06	0	0	None	N	None
8299	36	K/E	rs2077774413	0.1768	gnomAD-3.1.2	50	None	0.8362	0.9436	28.1	D	None	0.55	0.0663	-0.233	0.7347	0.7836	0.515361363251	None	0.700377	0.739	0.660424939923	0.998	0.635574221611	-2.71	0.688	0.482	0.007	None	None	6.57E-06	0	6.55E-05	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
8299	36	K/E	rs2077774413	0.1768	gnomAD-4.0.0	50	None	0.8362	0.9436	28.1	D	None	0.55	0.0663	-0.233	0.7347	0.7836	0.515361363251	None	0.700377	0.739	0.660424939923	0.998	0.635574221611	-2.71	0.688	0.482	0.007	None	None	6.57255E-06	0	6.54536E-05	0	0	None	0	0	6.57255E-06	0	0	0	None	N	None
8299	36	K/R	None	0.1768	gnomAD-4.0.0	50	None	0.0978	0.1185	24.2	N	None	0.76	0.023322	-0.761	0.3192	-0.4018	0.184979338227	None	1.0	0.662	0.293502639404	0.726	0.577593207359	-1.86	0.292	0.33	0.013	None	None	1.36967E-06	0	0	0	0	None	0	0	1.36967E-06	1.79905E-06	0	0	None	N	None
8300	37	E/D	rs1438429191	0.6243	gnomAD-2.1.1	51	None	0.1	0.1174	22.1	N	0.092	1.28	0.029122	-0.265	0.0575	-1.0911	0.0757698424566	None	1.0	0.518	0.0297737177859	None	0.519562244415	-0.99	0.14	0.123	0.862	None	None	4.03E-06	0	0	0	0	None	3.27E-05	None	4.03E-06	0	0	0	None	N	None
8300	37	E/D	rs1438429191	0.6243	gnomAD-4.0.0	51	None	0.1	0.1174	22.1	N	0.092	1.28	0.029122	-0.265	0.0575	-1.0911	0.0757698424566	None	1.0	0.518	0.0297737177859	None	0.519562244415	-0.99	0.14	0.123	0.862	None	None	6.8472E-07	0	0	0	0	None	0	0	6.8472E-07	0	1.15942E-05	0	None	N	None
8300	37	E/K	rs1300968279	0.6243	gnomAD-3.1.2	51	None	0.2401	0.3057	24.0	N	None	0.99	0.051241	0.131	0.2027	-0.7899	0.120506696489	None	0.936323	0.668	0.32980341726	0.236	0.604220271111	-2.41	0.359	0.285	0.415	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
8300	37	E/K	rs1300968279	0.6243	gnomAD-4.0.0	51	None	0.2401	0.3057	24.0	N	None	0.99	0.051241	0.131	0.2027	-0.7899	0.120506696489	None	0.936323	0.668	0.32980341726	0.236	0.604220271111	-2.41	0.359	0.285	0.415	None	None	6.57583E-06	2.41546E-05	0	0	0	None	0	0	6.57583E-06	0	0	0	None	N	None
8300	37	E/Q	rs1300968279	0.6243	gnomAD-2.1.1	51	None	0.1641	0.1896	23.4	N	0.28	0.96	0.029905	0.035	0.2739	-0.571	0.12641451465	None	0.767255	0.572	0.257292322809	0.52	0.506376981735	-1.67	0.318	0.315	0.08	None	None	4.03E-06	0	2.9E-05	0	0	None	0	None	4.03E-06	0	0	0	None	N	None
8300	37	E/Q	rs1300968279	0.6243	gnomAD-3.1.2	51	None	0.1641	0.1896	23.4	N	0.28	0.96	0.029905	0.035	0.2739	-0.571	0.12641451465	None	0.767255	0.572	0.257292322809	0.52	0.506376981735	-1.67	0.318	0.315	0.08	None	None	6.58E-06	0	6.55E-05	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
8300	37	E/Q	rs1300968279	0.6243	gnomAD-4.0.0	51	None	0.1641	0.1896	23.4	N	0.28	0.96	0.029905	0.035	0.2739	-0.571	0.12641451465	None	0.767255	0.572	0.257292322809	0.52	0.506376981735	-1.67	0.318	0.315	0.08	None	None	5.13343E-06	0	6.77897E-05	0	0	None	0	0	5.13343E-06	0	0	0	None	N	None
8301	38	H/L	rs763397399	0.8512	gnomAD-2.1.1	52	None	0.153	0.1792	23.4	N	0.711	1.02	0.03999	1.059	0.1869	-0.8604	0.107542735715	None	1.0	0.612	0.554235320232	0.01	0.549643278122	-5.18	0.393	0.287	0.213	None	None	4.03E-06	0	0	0	0	None	3.27E-05	None	4.03E-06	0	0	0	None	N	None
8301	38	H/L	rs763397399	0.8512	gnomAD-4.0.0	52	None	0.153	0.1792	23.4	N	0.711	1.02	0.03999	1.059	0.1869	-0.8604	0.107542735715	None	1.0	0.612	0.554235320232	0.01	0.549643278122	-5.18	0.393	0.287	0.213	None	None	1.59372E-06	0	0	0	0	None	0	0	1.59372E-06	0	0	3.02499E-05	None	N	None
8301	38	H/N	rs375389220	0.8512	gnomAD-3.1.2	52	None	0.0441	0.0495	22.0	N	0.09	1.15	0.008761	0.272	0.1	-0.9454	0.0948894062575	None	1.0	0.465	0.190952846119	0.002	0.574995875359	-2.64	0.23	0.209	0.696	None	None	6.57E-06	0	0	0	1.92604E-04	None	0	0	6.57E-06	0	0	0	None	N	None
8301	38	H/N	rs375389220	0.8512	1000 genomes	52	None	0.0441	0.0495	22.0	N	0.09	1.15	0.008761	0.272	0.1	-0.9454	0.0948894062575	None	1.0	0.465	0.190952846119	0.002	0.574995875359	-2.64	0.23	0.209	0.696	None	None	1.99681E-04	0	0	None	1E-03	0	None	None	1.99681E-04	None	0	None	None	N	None
8301	38	H/N	rs375389220	0.8512	gnomAD-4.0.0	52	None	0.0441	0.0495	22.0	N	0.09	1.15	0.008761	0.272	0.1	-0.9454	0.0948894062575	None	1.0	0.465	0.190952846119	0.002	0.574995875359	-2.64	0.23	0.209	0.696	None	None	6.56901E-06	0	0	0	1.9305E-04	None	0	0	6.56901E-06	0	0	0	None	N	None
8301	38	H/Y	rs375389220	0.8512	gnomAD-2.1.1	52	None	0.1121	0.1314	22.0	N	0.925	1.02	0.016409	1.227	0.193	-0.7852	0.119823001856	None	1.0	0.562	0.332133492242	0.178	0.585453987122	-2.89	0.275	0.4	0.069	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.89E-06	0	None	N	None
8301	38	H/Y	rs375389220	0.8512	gnomAD-4.0.0	52	None	0.1121	0.1314	22.0	N	0.925	1.02	0.016409	1.227	0.193	-0.7852	0.119823001856	None	1.0	0.562	0.332133492242	0.178	0.585453987122	-2.89	0.275	0.4	0.069	None	None	2.05425E-06	0	0	0	0	None	0	0	2.05425E-06	2.69856E-06	0	0	None	N	None
8302	39	T/A	None	0.4148	gnomAD-4.0.0	55	None	0.1054	0.1393	22.7	N	None	-0.2	0.024182	-0.515	0.142	-0.912	0.0832598698767	None	1.0	0.372	0.141422826196	0.005	0.544965982437	-2.54	0.145	0.216	0.158	None	None	6.84604E-07	0	0	0	0	None	0	0	6.84604E-07	0	1.15942E-05	0	None	N	None
8302	39	T/K	rs549604128	0.4148	gnomAD-2.1.1	55	None	0.2482	0.3521	23.4	N	-0.452	-0.12	0.043562	-0.347	0.139	-0.946	0.101295607235	None	1.0	0.497	0.272205846399	0.011	0.641900897026	-2.47	0.275	0.245	1.0	None	None	8.94E-05	0	0	0	1.1784E-03	None	6.54E-05	None	8.94E-05	0	0	0	None	N	None
8302	39	T/K	rs549604128	0.4148	gnomAD-3.1.2	55	None	0.2482	0.3521	23.4	N	-0.452	-0.12	0.043562	-0.347	0.139	-0.946	0.101295607235	None	1.0	0.497	0.272205846399	0.011	0.641900897026	-2.47	0.275	0.245	1.0	None	None	5.26E-05	0	0	0	1.54321E-03	None	0	0	5.26E-05	0	0	0	None	N	None
8302	39	T/K	rs549604128	0.4148	1000 genomes	55	None	0.2482	0.3521	23.4	N	-0.452	-0.12	0.043562	-0.347	0.139	-0.946	0.101295607235	None	1.0	0.497	0.272205846399	0.011	0.641900897026	-2.47	0.275	0.245	1.0	None	None	3.99361E-04	0	0	None	2E-03	0	None	None	3.99361E-04	None	0	None	None	N	None
8302	39	T/K	rs549604128	0.4148	gnomAD-4.0.0	55	None	0.2482	0.3521	23.4	N	-0.452	-0.12	0.043562	-0.347	0.139	-0.946	0.101295607235	None	1.0	0.497	0.272205846399	0.011	0.641900897026	-2.47	0.275	0.245	1.0	None	None	2.23197E-05	0	0	0	6.24108E-04	None	0	1.65125E-04	2.23197E-05	0	6.58848E-05	1.60092E-05	None	N	None
8302	39	T/S	None	0.4148	gnomAD-4.0.0	55	None	0.144	0.1769	22.4	N	None	-0.07	0.023402	-0.654	0.1414	-0.9172	0.0753460736105	None	1.0	0.354	0.12205267543	None	0.558109283447	-1.82	0.064	0.148	0.16	None	None	6.84604E-07	0	0	0	0	None	0	0	6.84604E-07	8.99517E-07	0	0	None	N	None
8305	42	R/Q	rs759985618	0.5338	gnomAD-2.1.1	59	None	0.3994	0.383	23.6	N	0.091	-0.25	0.042962	0.025	0.2788	-0.529	0.260930331339	None	1.0	0.534	0.247322355667	0.948	0.536946117878	-2.0	0.267	0.335	0.324	None	None	5.23E-05	0	2.89788E-04	0	5.57E-05	None	0	None	5.23E-05	0	1.78E-05	0	None	N	None
8305	42	R/Q	rs759985618	0.5338	gnomAD-3.1.2	59	None	0.3994	0.383	23.6	N	0.091	-0.25	0.042962	0.025	0.2788	-0.529	0.260930331339	None	1.0	0.534	0.247322355667	0.948	0.536946117878	-2.0	0.267	0.335	0.324	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
8305	42	R/Q	rs759985618	0.5338	gnomAD-4.0.0	59	None	0.3994	0.383	23.6	N	0.091	-0.25	0.042962	0.025	0.2788	-0.529	0.260930331339	None	1.0	0.534	0.247322355667	0.948	0.536946117878	-2.0	0.267	0.335	0.324	None	None	3.34745E-05	0	2.33403E-04	0	2.22846E-05	None	0	0	3.34745E-05	3.05163E-05	0	4.80369E-05	None	N	None
8306	43	S/L	rs776712129	0.5712	gnomAD-2.1.1	70	None	0.1327	0.1531	24.1	D	0.228	-0.44	0.043158	-0.004	0.4183	-0.2602	0.332889316541	None	0.723947	0.614	0.71767939224	0.932	0.596795558929	-4.04	0.48	0.428	0.053	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	N	None
8306	43	S/L	rs776712129	0.5712	gnomAD-3.1.2	70	None	0.1327	0.1531	24.1	D	0.228	-0.44	0.043158	-0.004	0.4183	-0.2602	0.332889316541	None	0.723947	0.614	0.71767939224	0.932	0.596795558929	-4.04	0.48	0.428	0.053	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
8306	43	S/L	rs776712129	0.5712	gnomAD-4.0.0	70	None	0.1327	0.1531	24.1	D	0.228	-0.44	0.043158	-0.004	0.4183	-0.2602	0.332889316541	None	0.723947	0.614	0.71767939224	0.932	0.596795558929	-4.04	0.48	0.428	0.053	None	None	1.36365E-05	0	0	0	2.22826E-05	None	0	0	1.36365E-05	1.78009E-05	0	0	None	N	None
8307	44	A/G	rs2077769834	0.3233	gnomAD-4.0.0	73	None	0.1604	0.2219	23.5	N	None	1.2	0.070959	-0.373	0.1059	-0.8905	0.0839709123402	None	1.0	0.547	0.295974979623	None	0.412681728601	-1.45	0.216	0.106	0.452	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	0	3.66327E-05	None	N	None
8308	45	P/S	rs373770383	0.8927	gnomAD-2.1.1	102	None	0.1619	0.242	None	N	0.067	None	None	-0.445	None	None	None	None	None	None	None	0.116	None	None	0.177	0.319	None	None	None	4.64E-05	5.37279E-04	0	0	0	None	0	None	4.64E-05	0	0	0	None	N	None
8308	45	P/S	rs373770383	0.8927	gnomAD-3.1.2	102	None	0.1619	0.242	None	N	0.067	None	None	-0.445	None	None	None	None	None	None	None	0.116	None	None	0.177	0.319	None	None	None	1.38053E-04	4.82695E-04	0	0	0	None	0	0	1.38053E-04	0	0	4.78927E-04	None	N	None
8308	45	P/S	rs373770383	0.8927	gnomAD-4.0.0	102	None	0.1619	0.242	None	N	0.067	None	None	-0.445	None	None	None	None	None	None	None	0.116	None	None	0.177	0.319	None	None	None	2.23131E-05	4.53999E-04	0	0	0	None	0	0	2.23131E-05	0	0	3.20277E-05	None	N	None
8309	46	A/E	rs186598275	0.2881	gnomAD-2.1.1	115	None	0.256	0.2935	23.0	N	-0.496	1.04	0.034582	-0.648	0.1622	-0.7294	0.237544240872	None	1.0	0.551	0.445007932271	0.965	0.555268168449	-2.21	0.26	0.345	0.952	None	None	4.02E-06	0	0	0	5.56E-05	None	0	None	4.02E-06	0	0	0	None	N	None
8309	46	A/E	rs186598275	0.2881	gnomAD-3.1.2	115	None	0.256	0.2935	23.0	N	-0.496	1.04	0.034582	-0.648	0.1622	-0.7294	0.237544240872	None	1.0	0.551	0.445007932271	0.965	0.555268168449	-2.21	0.26	0.345	0.952	None	None	6.57E-06	0	0	0	1.92976E-04	None	0	0	6.57E-06	0	0	0	None	N	None
8309	46	A/E	rs186598275	0.2881	gnomAD-4.0.0	115	None	0.256	0.2935	23.0	N	-0.496	1.04	0.034582	-0.648	0.1622	-0.7294	0.237544240872	None	1.0	0.551	0.445007932271	0.965	0.555268168449	-2.21	0.26	0.345	0.952	None	None	6.5678E-06	0	0	0	1.93424E-04	None	0	0	6.5678E-06	0	0	0	None	N	None
8309	46	A/V	rs186598275	0.2881	gnomAD-2.1.1	115	None	0.1359	0.1538	None	N	-0.202	None	None	-0.318	None	None	None	None	None	None	None	0.965	None	None	0.259	0.323	None	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	N	None
8309	46	A/V	rs186598275	0.2881	gnomAD-3.1.2	115	None	0.1359	0.1538	None	N	-0.202	None	None	-0.318	None	None	None	None	None	None	None	0.965	None	None	0.259	0.323	None	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
8309	46	A/V	rs186598275	0.2881	gnomAD-4.0.0	115	None	0.1359	0.1538	None	N	-0.202	None	None	-0.318	None	None	None	None	None	None	None	0.965	None	None	0.259	0.323	None	None	None	6.5678E-06	0	0	0	0	None	0	0	6.5678E-06	1.4705E-05	0	0	None	N	None
8310	47	Y/C	rs879064808	0.2394	gnomAD-2.1.1	121	None	0.1078	0.1556	23.3	N	-1.504	-0.39	0.040287	-1.44	0.2971	-0.5282	0.129670516642	None	1.0	0.591	0.507987536778	0.27	0.636162340641	-5.75	0.371	0.421	0.124	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
8310	47	Y/C	rs879064808	0.2394	gnomAD-4.0.0	121	None	0.1078	0.1556	23.3	N	-1.504	-0.39	0.040287	-1.44	0.2971	-0.5282	0.129670516642	None	1.0	0.591	0.507987536778	0.27	0.636162340641	-5.75	0.371	0.421	0.124	None	None	3.42137E-06	0	0	0	0	None	0	0	3.42137E-06	1.79903E-06	3.4781E-05	0	None	N	None
8310	47	Y/H	None	0.2394	gnomAD-4.0.0	121	None	0.3683	0.501	22.4	D	None	-0.34	0.024597	-1.636	0.3091	-0.5704	0.150913466129	None	1.0	0.647	0.370608029945	0.046	0.638131439686	-2.61	0.319	0.313	0.413	None	None	6.84287E-07	0	0	0	0	None	0	0	6.84287E-07	8.99525E-07	0	0	None	N	None
8310	47	Y/N	rs397517511	0.2394	gnomAD-2.1.1	121	None	0.4197	0.5365	23.6	N	-2.546	-0.4	0.058055	-2.062	0.4749	0.014	0.504618249758	None	0.582652	0.621	0.837140343473	0.987	0.633361577988	-5.51	0.513	0.628	0.216	None	None	1.21E-05	0	0	0	1.66963E-04	None	0	None	1.21E-05	0	0	0	None	N	None
8310	47	Y/N	rs397517511	0.2394	gnomAD-3.1.2	121	None	0.4197	0.5365	23.6	N	-2.546	-0.4	0.058055	-2.062	0.4749	0.014	0.504618249758	None	0.582652	0.621	0.837140343473	0.987	0.633361577988	-5.51	0.513	0.628	0.216	None	None	1.31E-05	0	0	0	3.85505E-04	None	0	0	1.31E-05	0	0	0	None	N	None
8310	47	Y/N	rs397517511	0.2394	gnomAD-4.0.0	121	None	0.4197	0.5365	23.6	N	-2.546	-0.4	0.058055	-2.062	0.4749	0.014	0.504618249758	None	0.582652	0.621	0.837140343473	0.987	0.633361577988	-5.51	0.513	0.628	0.216	None	None	4.33831E-06	0	0	0	1.11403E-04	None	0	0	4.33831E-06	0	0	3.20236E-05	None	N	None
8311	48	K/N	rs749075617	0.5229	gnomAD-2.1.1	122	None	0.6707	0.6912	24.0	N	-0.049	-0.29	0.021388	-0.029	0.3197	-0.5359	0.478553246808	None	1.0	0.575	0.17258766438	0.999	0.69569671154	-2.81	0.304	0.505	0.253	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
8311	48	K/N	rs749075617	0.5229	gnomAD-4.0.0	122	None	0.6707	0.6912	24.0	N	-0.049	-0.29	0.021388	-0.029	0.3197	-0.5359	0.478553246808	None	1.0	0.575	0.17258766438	0.999	0.69569671154	-2.81	0.304	0.505	0.253	None	None	1.59155E-06	0	2.28645E-05	0	0	None	0	0	1.59155E-06	0	0	0	None	N	None
8312	49	M/I	None	0.2664	gnomAD-4.0.0	123	None	0.409	0.4011	22.5	N	None	-0.1	0.025457	-0.928	0.1131	-0.9829	0.0925954833539	None	1.0	0.507	0.385417323374	None	0.663967192173	-1.86	0.115	0.111	0.38	None	None	1.59157E-06	0	0	0	0	None	0	0	1.59157E-06	2.85871E-06	0	0	None	N	None
8312	49	M/T	rs756314449	0.2664	gnomAD-2.1.1	123	None	0.5561	0.6962	23.0	N	-1.101	-0.28	0.063643	-1.247	0.2368	-0.7685	0.0979231966472	None	1.0	0.605	0.788997730761	0.001	0.743738770485	-3.63	0.353	0.223	0.008	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
8312	49	M/T	rs756314449	0.2664	gnomAD-3.1.2	123	None	0.5561	0.6962	23.0	N	-1.101	-0.28	0.063643	-1.247	0.2368	-0.7685	0.0979231966472	None	1.0	0.605	0.788997730761	0.001	0.743738770485	-3.63	0.353	0.223	0.008	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	0	2.07211E-04	0	None	N	None
8312	49	M/T	rs756314449	0.2664	gnomAD-4.0.0	123	None	0.5561	0.6962	23.0	N	-1.101	-0.28	0.063643	-1.247	0.2368	-0.7685	0.0979231966472	None	1.0	0.605	0.788997730761	0.001	0.743738770485	-3.63	0.353	0.223	0.008	None	None	5.12522E-06	0	0	0	0	None	0	0	5.12522E-06	0	5.36049E-05	0	None	N	None
8312	49	M/V	rs777456359	0.2664	gnomAD-2.1.1	123	None	0.1598	0.1778	22.6	N	-1.076	0.01	0.030146	-1.264	0.148	-0.9378	0.085014186535	None	1.0	0.501	0.427368086475	0.001	0.605790376663	-2.04	0.134	0.097	0.531	None	None	4.02E-06	6.46E-05	0	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
8312	49	M/V	rs777456359	0.2664	gnomAD-4.0.0	123	None	0.1598	0.1778	22.6	N	-1.076	0.01	0.030146	-1.264	0.148	-0.9378	0.085014186535	None	1.0	0.501	0.427368086475	0.001	0.605790376663	-2.04	0.134	0.097	0.531	None	None	1.59155E-06	0	0	0	0	None	0	0	1.59155E-06	2.85869E-06	0	0	None	N	None
8314	51	F/L	rs570367600	0.2327	gnomAD-2.1.1	127	None	0.9472	0.9669	21.5	N	-1.189	-0.23	0.059553	-1.166	0.1902	-0.8479	0.0995600239955	None	1.0	0.588	0.251116650651	0.014	0.681156814098	-2.69	0.263	0.321	0.65	None	None	1.61E-05	0	0	0	5.57E-05	None	9.8E-05	None	1.61E-05	0	0	0	None	N	None
8314	51	F/L	rs570367600	0.2327	gnomAD-3.1.2	127	None	0.9472	0.9669	21.5	N	-1.189	-0.23	0.059553	-1.166	0.1902	-0.8479	0.0995600239955	None	1.0	0.588	0.251116650651	0.014	0.681156814098	-2.69	0.263	0.321	0.65	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	0	2.07125E-04	0	None	N	None
8314	51	F/L	rs570367600	0.2327	1000 genomes	127	None	0.9472	0.9669	21.5	N	-1.189	-0.23	0.059553	-1.166	0.1902	-0.8479	0.0995600239955	None	1.0	0.588	0.251116650651	0.014	0.681156814098	-2.69	0.263	0.321	0.65	None	None	1.99681E-04	0	0	None	0	0	None	None	1.99681E-04	None	1E-03	None	None	N	None
8314	51	F/L	rs570367600	0.2327	gnomAD-4.0.0	127	None	0.9472	0.9669	21.5	N	-1.189	-0.23	0.059553	-1.166	0.1902	-0.8479	0.0995600239955	None	1.0	0.588	0.251116650651	0.014	0.681156814098	-2.69	0.263	0.321	0.65	None	None	1.11405E-05	0	0	0	2.773E-05	None	0	0	1.11405E-05	0	8.59747E-05	0	None	N	None
8317	54	N/I	rs1278554973	0.5014	gnomAD-2.1.1	134	None	0.8024	0.8864	22.6	N	0.219	-0.33	0.045745	0.149	0.5452	0.1538	0.497776733095	None	1.0	0.583	0.746569793032	1.0	0.61870598793	-5.05	0.509	0.769	0.026	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	N	None
8317	54	N/I	rs1278554973	0.5014	gnomAD-4.0.0	134	None	0.8024	0.8864	22.6	N	0.219	-0.33	0.045745	0.149	0.5452	0.1538	0.497776733095	None	1.0	0.583	0.746569793032	1.0	0.61870598793	-5.05	0.509	0.769	0.026	None	None	4.10542E-06	2.989E-05	0	0	0	None	0	0	4.10542E-06	4.49755E-06	0	0	None	N	None
8317	54	N/K	rs370154022	0.5014	gnomAD-2.1.1	134	None	0.518	0.5894	16.26	N	0.091	-0.22	0.021779	-0.156	0.3626	-0.2353	0.450581664756	None	0.999991	0.683	0.0716867268079	0.999	0.67198574543	-3.32	0.374	0.59	0.271	None	None	1.61E-05	2.58331E-04	0	0	0	None	0	None	1.61E-05	0	0	0	None	N	None
8317	54	N/K	rs370154022	0.5014	gnomAD-3.1.2	134	None	0.518	0.5894	16.26	N	0.091	-0.22	0.021779	-0.156	0.3626	-0.2353	0.450581664756	None	0.999991	0.683	0.0716867268079	0.999	0.67198574543	-3.32	0.374	0.59	0.271	None	None	7.89E-05	2.89645E-04	0	0	0	None	0	0	7.89E-05	0	0	0	None	N	None
8317	54	N/K	rs370154022	0.5014	gnomAD-4.0.0	134	None	0.518	0.5894	16.26	N	0.091	-0.22	0.021779	-0.156	0.3626	-0.2353	0.450581664756	None	0.999991	0.683	0.0716867268079	0.999	0.67198574543	-3.32	0.374	0.59	0.271	None	None	1.11553E-05	2.13658E-04	0	0	0	None	0	0	1.11553E-05	1.69532E-06	0	0	None	N	None
8318	55	V/I	rs200103997	0.1834	gnomAD-2.1.1	135	None	0.0644	0.0654	None	N	-0.731	None	None	-0.856	None	None	None	None	None	None	None	0.008	None	None	0.063	0.189	None	None	None	5.74659E-04	8.27E-05	2.83E-05	0	0	None	0	None	5.74659E-04	3.19872E-04	1.14055E-03	5.61798E-04	None	N	None
8318	55	V/I	rs200103997	0.1834	gnomAD-3.1.2	135	None	0.0644	0.0654	None	N	-0.731	None	None	-0.856	None	None	None	None	None	None	None	0.008	None	None	0.063	0.189	None	None	None	5.45572E-04	4.82E-05	6.55E-05	0	0	None	9.43E-05	0	5.45572E-04	1.14703E-03	0	4.78011E-04	None	N	None
8318	55	V/I	rs200103997	0.1834	1000 genomes	135	None	0.0644	0.0654	None	N	-0.731	None	None	-0.856	None	None	None	None	None	None	None	0.008	None	None	0.063	0.189	None	None	None	1.99681E-04	0	0	None	0	1E-03	None	None	1.99681E-04	None	0	None	None	N	None
8318	55	V/I	rs200103997	0.1834	gnomAD-4.0.0	135	None	0.0644	0.0654	None	N	-0.731	None	None	-0.856	None	None	None	None	None	None	None	0.008	None	None	0.063	0.189	None	None	None	7.49198E-04	9.32935E-05	1.33316E-04	0	2.22856E-05	None	2.18757E-04	0	7.49198E-04	9.73976E-04	0	4.80169E-04	None	N	None
8319	56	A/P	None	0.0930	gnomAD-4.0.0	136	None	0.9814	0.9866	22.0	N	None	0.92	0.033539	0.12	0.32	-0.4197	0.141694267701	None	0.681379	0.77	0.479056812784	0.982	0.673500299454	-2.94	0.426	0.503	0.21	None	None	4.80129E-06	0	0	0	0	None	0	0	4.80129E-06	5.25001E-06	0	0	None	N	None
8319	56	A/T	rs2077763797	0.0930	gnomAD-3.1.2	136	None	0.609	0.7126	23.2	D	None	1.01	0.017392	-1.146	0.4321	-0.2301	0.395001678641	None	1.0	0.557	0.463157528383	1.0	0.635374426842	-1.98	0.375	0.685	0.441	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	0	2.07125E-04	0	None	N	None
8319	56	A/T	rs2077763797	0.0930	gnomAD-4.0.0	136	None	0.609	0.7126	23.2	D	None	1.01	0.017392	-1.146	0.4321	-0.2301	0.395001678641	None	1.0	0.557	0.463157528383	1.0	0.635374426842	-1.98	0.375	0.685	0.441	None	None	6.57263E-06	0	0	0	0	None	0	0	6.57263E-06	0	2.07125E-04	0	None	N	None
8319	56	A/V	None	0.0930	gnomAD-4.0.0	136	None	0.5089	0.6257	25.2	N	None	1.01	0.034981	0.12	0.3925	-0.2453	0.283650765552	None	0.750285	0.549	0.649000688064	0.998	0.640596985817	-1.82	0.377	0.679	0.501	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
8320	57	S/C	rs1374151646	0.1446	gnomAD-3.1.2	137	None	0.1115	0.1228	21.9	D	None	-0.41	0.010841	-0.522	0.3352	-0.3848	0.238441029153	None	0.999995	0.661	0.541285430251	0.955	0.558242917061	-2.64	0.368	0.689	0.176	None	None	1.31E-05	0	0	0	0	None	0	3.16456E-03	1.31E-05	1.47E-05	0	0	None	N	None
8320	57	S/C	rs1374151646	0.1446	gnomAD-4.0.0	137	None	0.1115	0.1228	21.9	D	None	-0.41	0.010841	-0.522	0.3352	-0.3848	0.238441029153	None	0.999995	0.661	0.541285430251	0.955	0.558242917061	-2.64	0.368	0.689	0.176	None	None	1.31377E-05	0	0	0	0	None	0	3.40136E-03	1.31377E-05	1.47059E-05	0	0	None	N	None
8320	57	S/F	rs1374151646	0.1446	gnomAD-2.1.1	137	None	0.1479	0.1707	22.1	N	-0.508	-0.38	0.022884	-0.448	0.4087	-0.2025	0.307678943873	None	0.999993	0.65	0.732106347842	0.988	0.596597194672	-3.31	0.4	0.753	0.749	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	0	1.65782E-04	None	N	None
8320	57	S/F	rs1374151646	0.1446	gnomAD-4.0.0	137	None	0.1479	0.1707	22.1	N	-0.508	-0.38	0.022884	-0.448	0.4087	-0.2025	0.307678943873	None	0.999993	0.65	0.732106347842	0.988	0.596597194672	-3.31	0.4	0.753	0.749	None	None	4.77415E-06	0	0	0	0	None	0	2.41196E-04	4.77415E-06	2.85868E-06	0	3.02371E-05	None	N	None
8322	59	V/A	None	0.2617	gnomAD-4.0.0	139	None	0.201	0.2602	22.7	D	None	-0.25	0.033626	-1.703	0.2426	-0.69	0.107757450643	None	1.0	0.437	0.551879694509	0.013	0.488391727209	-2.07	0.199	0.305	0.662	None	None	4.77412E-06	0	0	0	0	None	0	0	4.77412E-06	8.57604E-06	0	0	None	N	None
8322	59	V/I	rs201571580	0.2617	gnomAD-2.1.1	139	None	0.0721	0.0768	16.63	N	-0.466	-0.21	0.053094	-0.734	0.199	-0.715	0.0923104026752	None	1.0	0.467	0.539612970712	0.602	0.373354524374	-0.59	0.178	0.539	0.405	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	N	None
8322	59	V/I	rs201571580	0.2617	gnomAD-4.0.0	139	None	0.0721	0.0768	16.63	N	-0.466	-0.21	0.053094	-0.734	0.199	-0.715	0.0923104026752	None	1.0	0.467	0.539612970712	0.602	0.373354524374	-0.59	0.178	0.539	0.405	None	None	6.84232E-07	0	0	0	0	None	0	0	6.84232E-07	8.99514E-07	0	0	None	N	None
8322	59	V/L	rs201571580	0.2617	gnomAD-2.1.1	139	None	0.1489	0.1842	17.26	N	-0.5	-0.24	0.038771	-0.734	0.2236	-0.7201	0.101652822603	None	1.0	0.474	0.451118754121	0.385	0.467262268066	-1.68	0.184	0.555	0.324	None	None	5.88962E-04	8.27E-05	5.66E-05	0	0	None	0	None	5.88962E-04	3.19744E-04	1.17191E-03	4.21467E-04	None	N	None
8322	59	V/L	rs201571580	0.2617	gnomAD-3.1.2	139	None	0.1489	0.1842	17.26	N	-0.5	-0.24	0.038771	-0.734	0.2236	-0.7201	0.101652822603	None	1.0	0.474	0.451118754121	0.385	0.467262268066	-1.68	0.184	0.555	0.324	None	None	4.86349E-04	1.20656E-04	1.30959E-04	0	0	None	7.53721E-04	0	4.86349E-04	8.52766E-04	0	4.77555E-04	None	N	None
8322	59	V/L	rs201571580	0.2617	gnomAD-4.0.0	139	None	0.1489	0.1842	17.26	N	-0.5	-0.24	0.038771	-0.734	0.2236	-0.7201	0.101652822603	None	1.0	0.474	0.451118754121	0.385	0.467262268066	-1.68	0.184	0.555	0.324	None	None	6.38259E-04	1.46631E-04	8.33167E-05	0	0	None	5.31184E-04	0	6.38259E-04	7.94258E-04	0	6.88154E-04	None	N	None
8324	61	N/K	rs879030954	0.5461	gnomAD-4.0.0	141	None	0.3636	0.3905	20.6	N	None	-0.15	0.011128	-0.05	0.1496	-0.9379	0.0984812597332	None	1.0	0.548	0.126345400529	0.023	0.594977855682	-3.05	0.102	0.05	0.55	None	None	4.10537E-06	0	2.23614E-05	0	0	None	0	0	4.10537E-06	4.49757E-06	0	0	None	I	None
8325	62	K/E	rs72648984	0.6672	gnomAD-2.1.1	143	None	0.161	0.1957	None	N	0.424	None	None	0.135	None	None	None	None	None	None	None	0.216	None	None	0.194	0.212	None	None	None	5.58292E-03	1.32253E-03	4.80715E-04	2.89967E-04	0	None	0	None	5.58292E-03	1.51854E-02	8.58054E-03	4.77394E-03	None	I	None
8325	62	K/E	rs72648984	0.6672	gnomAD-3.1.2	143	None	0.161	0.1957	None	N	0.424	None	None	0.135	None	None	None	None	None	None	None	0.216	None	None	0.194	0.212	None	None	None	4.66442E-03	1.18158E-03	1.50563E-03	2.88018E-04	0	None	1.58133E-02	0	4.66442E-03	6.82132E-03	2.07039E-04	1.43267E-03	None	I	None
8325	62	K/E	rs72648984	0.6672	1000 genomes	143	None	0.161	0.1957	None	N	0.424	None	None	0.135	None	None	None	None	None	None	None	0.216	None	None	0.194	0.212	None	None	None	1.59744E-03	0	0	None	0	8E-03	None	None	1.59744E-03	None	0	None	None	I	None
8325	62	K/E	rs72648984	0.6672	gnomAD-4.0.0	143	None	0.161	0.1957	None	N	0.424	None	None	0.135	None	None	None	None	None	None	None	0.216	None	None	0.194	0.212	None	None	None	5.69265E-03	1.07931E-03	7.49825E-04	2.02716E-04	0	None	1.51193E-02	0	5.69265E-03	6.65662E-03	3.29374E-05	3.68082E-03	None	I	None
8325	62	K/N	rs373995644	0.6672	gnomAD-2.1.1	143	None	0.3215	0.4114	22.4	N	0.325	1.17	0.018374	0.078	0.1026	-1.044	0.101269158521	None	1.0	0.581	0.0482279557977	0.056	0.555937290192	-2.28	0.103	0.151	0.475	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	I	None
8327	64	D/V	None	0.2791	gnomAD-4.0.0	145	None	0.3324	0.4058	24.5	N	None	-0.29	0.04565	0.16	0.3106	-0.4228	0.370455593846	None	0.999763	0.562	0.647137792213	0.97	0.472892045975	-4.78	0.41	0.437	0.049	None	None	1.5914E-06	0	0	0	2.77285E-05	None	0	0	1.5914E-06	0	0	0	None	I	None
8328	65	H/N	rs767212475	0.8645	gnomAD-2.1.1	146	None	0.0622	0.0584	21.0	N	0.233	1.03	0.006614	0.236	0.1556	-0.9779	0.0918443102936	None	1.0	0.474	0.190952846119	None	0.475518226624	-3.21	0.188	0.143	0.569	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	I	None
8329	66	S/G	None	0.5410	gnomAD-4.0.0	148	None	0.0824	0.0947	21.9	N	None	0.88	0.055603	-0.272	0.2396	-0.7818	0.0777633554608	None	1.0	0.531	0.15556083564	0.008	0.551880717278	-2.34	0.191	0.089	0.16	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	I	None
8329	66	S/N	None	0.5410	gnomAD-4.0.0	148	None	0.1013	0.1155	17.48	N	None	0.9	0.026864	-0.122	0.2387	-0.8337	0.0781518737448	None	1.0	0.513	0.165133752707	0.001	0.629538416862	-1.67	0.212	0.151	0.148	None	None	4.78965E-06	0	0	0	0	None	0	0	4.78965E-06	6.29665E-06	0	0	None	I	None
8330	67	D/H	None	0.1418	gnomAD-4.0.0	149	None	0.8203	0.8728	23.4	D	None	-1.54	0.030431	0.841	0.7234	0.5595	0.502564449384	None	0.971653	0.856	0.661693444866	1.0	0.664954841137	-5.03	0.644	0.845	0.003	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
8331	68	V/E	rs773888026	0.2797	gnomAD-2.1.1	151	None	0.1836	0.1846	22.4	N	-1.278	-0.08	0.023598	-0.505	0.1198	-0.9295	0.163884732891	None	0.999996	0.439	0.55973633643	0.064	0.507520318031	-3.44	0.235	0.544	0.91	None	None	4.02E-06	0	0	0	5.57E-05	None	0	None	4.02E-06	0	0	0	None	I	None
8331	68	V/E	rs773888026	0.2797	gnomAD-4.0.0	151	None	0.1836	0.1846	22.4	N	-1.278	-0.08	0.023598	-0.505	0.1198	-0.9295	0.163884732891	None	0.999996	0.439	0.55973633643	0.064	0.507520318031	-3.44	0.235	0.544	0.91	None	None	1.20032E-06	0	0	0	2.75482E-04	None	0	0	1.20032E-06	0	0	0	None	I	None
8332	69	G/E	rs2077756630	0.2195	gnomAD-3.1.2	152	None	0.9201	0.9633	24.4	D	None	-1.12	0.180783	-1.164	0.9024	1.0364	0.522941590875	None	0.92292	0.849	0.883990867487	1.0	0.772898793221	-5.75	0.699	0.839	None	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
8332	69	G/E	rs2077756630	0.2195	gnomAD-4.0.0	152	None	0.9201	0.9633	24.4	D	None	-1.12	0.180783	-1.164	0.9024	1.0364	0.522941590875	None	0.92292	0.849	0.883990867487	1.0	0.772898793221	-5.75	0.699	0.839	None	None	None	6.57212E-06	0	0	0	0	None	0	0	6.57212E-06	1.47024E-05	0	0	None	I	None
8333	70	E/D	rs1438182051	0.5040	gnomAD-2.1.1	153	None	0.1884	0.2281	19.47	N	-0.651	-0.3	0.025095	-1.194	0.2104	-0.7599	0.189792385673	None	1.0	0.483	0.233785782151	0.797	0.573844254017	-1.72	0.316	0.519	0.46	None	None	3.18E-05	0	0	0	0	None	0	None	3.18E-05	0	6.48E-05	0	None	I	None
8333	70	E/D	rs1438182051	0.5040	gnomAD-3.1.2	153	None	0.1884	0.2281	19.47	N	-0.651	-0.3	0.025095	-1.194	0.2104	-0.7599	0.189792385673	None	1.0	0.483	0.233785782151	0.797	0.573844254017	-1.72	0.316	0.519	0.46	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
8333	70	E/D	rs1438182051	0.5040	gnomAD-4.0.0	153	None	0.1884	0.2281	19.47	N	-0.651	-0.3	0.025095	-1.194	0.2104	-0.7599	0.189792385673	None	1.0	0.483	0.233785782151	0.797	0.573844254017	-1.72	0.316	0.519	0.46	None	None	2.56224E-06	0	0	0	0	None	0	0	2.56224E-06	4.78675E-06	0	0	None	I	None
8333	70	E/G	rs770811407	0.5040	gnomAD-2.1.1	153	None	0.241	0.3315	27.7	N	-1.337	-0.34	0.037732	-1.249	0.4485	-0.0529	0.397034993855	None	1.0	0.507	0.556183318313	0.99	0.536446213722	-4.49	0.515	0.627	0.277	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	I	None
8333	70	E/G	rs770811407	0.5040	gnomAD-4.0.0	153	None	0.241	0.3315	27.7	N	-1.337	-0.34	0.037732	-1.249	0.4485	-0.0529	0.397034993855	None	1.0	0.507	0.556183318313	0.99	0.536446213722	-4.49	0.515	0.627	0.277	None	None	7.95689E-06	0	0	0	0	None	3.76464E-05	0	7.95689E-06	2.85873E-06	0	6.04778E-05	None	I	None
8335	72	S/A	rs773006091	0.2275	gnomAD-2.1.1	155	None	0.0858	0.0973	18.14	N	-0.6	0.97	0.040249	-1.078	0.2025	-0.8662	0.0718162386562	None	1.0	0.47	0.0401082797425	0.005	0.335975348949	-1.17	0.123	0.427	0.058	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	N	None
8335	72	S/A	rs773006091	0.2275	gnomAD-4.0.0	155	None	0.0858	0.0973	18.14	N	-0.6	0.97	0.040249	-1.078	0.2025	-0.8662	0.0718162386562	None	1.0	0.47	0.0401082797425	0.005	0.335975348949	-1.17	0.123	0.427	0.058	None	None	6.84237E-07	0	0	0	0	None	0	0	6.84237E-07	8.99517E-07	0	0	None	N	None
8335	72	S/T	None	0.2275	gnomAD-4.0.0	155	None	0.0523	0.0481	17.21	N	None	1.21	0.019251	-0.102	0.0829	-1.0172	0.0763001356589	None	1.0	0.431	0.0297737177859	None	0.349194854498	0.96	0.093	0.203	1.0	None	None	6.84237E-07	0	0	0	0	None	0	0	6.84237E-07	8.99517E-07	0	0	None	N	None
8336	73	C/G	None	0.0714	gnomAD-4.0.0	156	None	0.9071	0.947	24.1	D	None	-0.12	0.024733	-1.867	0.8517	1.0074	0.503899149776	None	0.679459	0.83	0.925936472269	0.999	0.732709228992	-7.64	0.767	0.855	0.024	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	disulfide	N	None
8336	73	C/S	None	0.0714	gnomAD-4.0.0	156	None	0.9785	0.9886	23.6	D	None	-0.12	0.033492	-1.463	0.826	0.9407	0.469645049753	None	0.530669	0.8	0.862583160585	1.0	0.76245200634	-6.33	0.767	0.745	0.052	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	disulfide	N	None
8339	76	D/E	rs1283273345	0.3546	gnomAD-2.1.1	159	None	0.0517	0.0511	16.68	N	-0.57	-0.12	0.023836	-0.857	0.0675	-1.0631	0.0778949114422	None	1.0	0.357	0.0297737177859	None	0.735999047756	1.23	0.171	0.082	1.0	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	N	None
8339	76	D/E	rs1283273345	0.3546	gnomAD-4.0.0	159	None	0.0517	0.0511	16.68	N	-0.57	-0.12	0.023836	-0.857	0.0675	-1.0631	0.0778949114422	None	1.0	0.357	0.0297737177859	None	0.735999047756	1.23	0.171	0.082	1.0	None	None	4.77458E-06	0	0	0	0	None	0	0	4.77458E-06	8.57716E-06	0	0	None	N	None
8340	77	N/S	None	0.1707	gnomAD-4.0.0	161	None	0.7637	0.8449	24.5	D	None	0.32	0.022593	-0.932	0.6977	0.5634	0.417388960371	None	0.90574	0.838	0.483596354421	1.0	0.664352238178	-3.09	0.7	0.576	0.01	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	I	None
8341	78	S/R	rs1221926854	0.6272	gnomAD-2.1.1	162	None	0.475	0.4693	18.22	N	0.083	-0.4	0.05196	-0.173	0.186	-0.9477	0.130716481954	None	0.997996	0.591	0.0666544352282	0.132	0.568853735924	-2.4	0.306	0.379	0.141	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	I	None
8341	78	S/R	rs1221926854	0.6272	gnomAD-4.0.0	162	None	0.475	0.4693	18.22	N	0.083	-0.4	0.05196	-0.173	0.186	-0.9477	0.130716481954	None	0.997996	0.591	0.0666544352282	0.132	0.568853735924	-2.4	0.306	0.379	0.141	None	None	6.84318E-07	0	0	0	0	None	0	0	6.84318E-07	8.99638E-07	0	0	None	I	None
8343	80	G/A	rs1288642142	0.2637	gnomAD-2.1.1	164	None	0.7955	0.8948	24.6	D	-0.155	-0.86	0.032972	-0.479	0.7758	0.7344	0.480971576196	None	0.999642	0.921	0.63749958327	1.0	0.717276215553	-4.18	0.61	0.739	0.013	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	4.65E-05	0	0	None	I	None
8343	80	G/A	rs1288642142	0.2637	gnomAD-4.0.0	164	None	0.7955	0.8948	24.6	D	-0.155	-0.86	0.032972	-0.479	0.7758	0.7344	0.480971576196	None	0.999642	0.921	0.63749958327	1.0	0.717276215553	-4.18	0.61	0.739	0.013	None	None	1.59204E-06	0	0	0	0	None	1.88246E-05	0	1.59204E-06	0	0	0	None	I	None
8344	81	A/E	rs748045267	0.3413	gnomAD-2.1.1	165	None	0.1777	0.2022	22.1	N	-1.103	-0.07	0.008908	-1.169	0.0963	-0.9886	0.143017052064	None	1.0	0.439	0.489243007833	0.747	0.490457832813	-2.43	0.187	0.427	1.0	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	I	None
8344	81	A/E	rs748045267	0.3413	gnomAD-4.0.0	165	None	0.1777	0.2022	22.1	N	-1.103	-0.07	0.008908	-1.169	0.0963	-0.9886	0.143017052064	None	1.0	0.439	0.489243007833	0.747	0.490457832813	-2.43	0.187	0.427	1.0	None	None	1.59253E-06	0	0	0	0	None	0	0	1.59253E-06	2.86182E-06	0	0	None	I	None
8344	81	A/T	rs2077751372	0.3413	gnomAD-4.0.0	165	None	0.0798	0.0829	19.45	N	None	-0.23	0.017347	-0.793	0.1201	-0.9854	0.0813673231391	None	1.0	0.366	0.171388866994	0.004	0.431267499924	-1.87	0.096	0.247	0.442	None	None	1.36876E-06	0	0	0	0	None	0	0	1.36876E-06	1.79943E-06	0	0	None	I	None
8345	82	V/A	None	0.1191	gnomAD-4.0.0	166	None	0.1059	0.1261	21.0	N	None	-0.2	0.028636	-1.099	0.0968	-1.0181	0.101150159241	None	1.0	0.507	0.319114376414	None	0.430633634329	-1.74	0.139	0.084	0.956	None	None	6.37397E-06	0	2.28728E-05	0	0	None	0	0	6.37397E-06	8.59303E-06	0	0	None	I	None
8346	83	A/T	rs755302381	0.2884	gnomAD-2.1.1	168	None	0.07	0.0746	21.2	N	-0.515	-0.05	0.01985	-0.676	0.0836	-1.0011	0.0809002040292	None	0.999995	0.366	0.194818534648	0.008	0.443847596645	-1.24	0.118	0.199	0.424	None	None	2.01E-05	0	5.8E-05	0	0	None	0	None	2.01E-05	0	2.67E-05	0	None	I	None
8346	83	A/T	rs755302381	0.2884	gnomAD-3.1.2	168	None	0.07	0.0746	21.2	N	-0.515	-0.05	0.01985	-0.676	0.0836	-1.0011	0.0809002040292	None	0.999995	0.366	0.194818534648	0.008	0.443847596645	-1.24	0.118	0.199	0.424	None	None	1.31E-05	0	6.55E-05	0	0	None	0	0	1.31E-05	0	0	4.77555E-04	None	I	None
8346	83	A/T	rs755302381	0.2884	gnomAD-4.0.0	168	None	0.07	0.0746	21.2	N	-0.515	-0.05	0.01985	-0.676	0.0836	-1.0011	0.0809002040292	None	0.999995	0.366	0.194818534648	0.008	0.443847596645	-1.24	0.118	0.199	0.424	None	None	8.06179E-06	1.33536E-05	6.67045E-05	0	0	None	0	1.64636E-04	8.06179E-06	5.08983E-06	0	1.60241E-05	None	I	None
8346	83	A/V	rs747055472	0.2884	gnomAD-2.1.1	168	None	0.099	0.1148	22.2	N	-0.077	-0.27	0.014596	-0.276	0.1459	-0.8982	0.0831900980906	None	0.979965	0.422	0.40017627803	0.002	0.477882832289	-1.76	0.14	0.193	0.18	None	None	4.03E-06	0	0	0	5.56E-05	None	0	None	4.03E-06	0	0	0	None	I	None
8346	83	A/V	rs747055472	0.2884	gnomAD-4.0.0	168	None	0.099	0.1148	22.2	N	-0.077	-0.27	0.014596	-0.276	0.1459	-0.8982	0.0831900980906	None	0.979965	0.422	0.40017627803	0.002	0.477882832289	-1.76	0.14	0.193	0.18	None	None	1.5941E-06	0	0	0	2.77485E-05	None	0	0	1.5941E-06	0	0	0	None	I	None
8347	84	S/P	rs1345180729	0.1278	gnomAD-2.1.1	169	None	0.9683	0.9824	22.7	D	-0.261	-0.35	0.033293	-0.456	0.4043	-0.1293	0.270889457087	None	1.0	0.608	0.404034981753	0.917	0.566534996033	-3.24	0.427	0.801	0.028	None	None	4.03E-06	0	0	0	5.56E-05	None	0	None	4.03E-06	0	0	0	None	N	None
8347	84	S/P	rs1345180729	0.1278	gnomAD-4.0.0	169	None	0.9683	0.9824	22.7	D	-0.261	-0.35	0.033293	-0.456	0.4043	-0.1293	0.270889457087	None	1.0	0.608	0.404034981753	0.917	0.566534996033	-3.24	0.427	0.801	0.028	None	None	1.59401E-06	0	0	0	2.77485E-05	None	0	0	1.59401E-06	0	0	0	None	N	None
8349	86	A/G	rs397517513	0.0950	gnomAD-2.1.1	172	None	0.2036	0.2452	22.3	N	-1.461	-0.54	0.031155	-1.569	0.3016	-0.6346	0.105381379725	None	0.957415	0.61	0.316198179892	0.034	0.422765225172	-2.47	0.256	0.655	0.005	None	None	1.79E-05	0	0	0	0	None	0	None	1.79E-05	0	3.92E-05	0	None	N	None
8349	86	A/G	rs397517513	0.0950	gnomAD-3.1.2	172	None	0.2036	0.2452	22.3	N	-1.461	-0.54	0.031155	-1.569	0.3016	-0.6346	0.105381379725	None	0.957415	0.61	0.316198179892	0.034	0.422765225172	-2.47	0.256	0.655	0.005	None	None	1.97E-05	0	0	0	0	None	0	0	1.97E-05	4.41E-05	0	0	None	N	None
8349	86	A/G	rs397517513	0.0950	gnomAD-4.0.0	172	None	0.2036	0.2452	22.3	N	-1.461	-0.54	0.031155	-1.569	0.3016	-0.6346	0.105381379725	None	0.957415	0.61	0.316198179892	0.034	0.422765225172	-2.47	0.256	0.655	0.005	None	None	3.597E-05	0	0	0	0	None	0	0	3.597E-05	4.24185E-05	0	1.2818E-04	None	N	None
8349	86	A/P	rs1459194268	0.0950	gnomAD-2.1.1	172	None	0.9658	0.9833	19.67	D	-0.171	-0.55	0.034155	-0.602	0.5088	-0.3389	0.300339293675	None	1.0	0.741	0.460264052551	0.718	0.490117281675	-3.19	0.315	0.753	0.025	None	None	4.03E-06	0	0	0	0	None	3.28E-05	None	4.03E-06	0	0	0	None	N	None
8349	86	A/P	rs1459194268	0.0950	gnomAD-4.0.0	172	None	0.9658	0.9833	19.67	D	-0.171	-0.55	0.034155	-0.602	0.5088	-0.3389	0.300339293675	None	1.0	0.741	0.460264052551	0.718	0.490117281675	-3.19	0.315	0.753	0.025	None	None	1.59459E-06	0	0	0	0	None	0	0	1.59459E-06	0	1.43377E-05	0	None	N	None
8349	86	A/V	rs397517513	0.0950	gnomAD-3.1.2	172	None	0.3722	0.4372	22.3	N	None	-0.33	0.024382	-0.602	0.2613	-0.6019	0.106517594564	None	0.948261	0.613	0.458734620958	0.337	0.45827549696	-2.34	0.286	0.612	0.434	None	None	1.97E-05	7.24E-05	0	0	0	None	0	0	1.97E-05	0	0	0	None	N	None
8349	86	A/V	rs397517513	0.0950	gnomAD-4.0.0	172	None	0.3722	0.4372	22.3	N	None	-0.33	0.024382	-0.602	0.2613	-0.6019	0.106517594564	None	0.948261	0.613	0.458734620958	0.337	0.45827549696	-2.34	0.286	0.612	0.434	None	None	1.9714E-05	7.23938E-05	0	0	0	None	0	0	1.9714E-05	0	0	0	None	N	None
8350	87	V/A	rs915984764	0.1905	gnomAD-4.0.0	173	None	0.1679	0.1849	22.3	N	None	-0.19	0.019188	-1.365	0.1331	-0.8865	0.128169582595	None	0.999997	0.441	0.439339381091	0.174	0.530132055283	-1.81	0.208	0.251	0.402	None	None	2.0553E-06	0	0	0	0	None	0	1.73853E-04	2.0553E-06	9.00722E-07	1.16071E-05	0	None	I	None
8350	87	V/M	None	0.1905	gnomAD-3.1.2	173	None	0.1106	0.1193	20.9	N	None	-0.25	0.014292	-0.453	0.1783	-0.7419	0.194634777738	None	0.998933	0.458	0.417586769301	0.916	0.542351961136	-1.51	0.207	0.545	0.069	None	None	6.57E-06	0	0	0	1.92456E-04	None	0	0	6.57E-06	0	0	0	None	I	None
8350	87	V/M	None	0.1905	gnomAD-4.0.0	173	None	0.1106	0.1193	20.9	N	None	-0.25	0.014292	-0.453	0.1783	-0.7419	0.194634777738	None	0.998933	0.458	0.417586769301	0.916	0.542351961136	-1.51	0.207	0.545	0.069	None	None	6.5722E-06	0	0	0	1.92456E-04	None	0	0	6.5722E-06	0	0	0	None	I	None
8352	89	V/L	rs750897859	0.3289	gnomAD-2.1.1	175	None	0.125	0.1343	17.93	N	-0.232	-0.22	0.012425	-0.419	0.1649	-0.9098	0.0822650963644	None	1.0	0.554	0.358340041657	0.001	0.48454362154	-1.39	0.194	0.257	0.46	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.92E-06	0	None	I	None
8352	89	V/L	rs750897859	0.3289	gnomAD-4.0.0	175	None	0.125	0.1343	17.93	N	-0.232	-0.22	0.012425	-0.419	0.1649	-0.9098	0.0822650963644	None	1.0	0.554	0.358340041657	0.001	0.48454362154	-1.39	0.194	0.257	0.46	None	None	9.58653E-06	0	0	0	0	None	0	0	9.58653E-06	1.72491E-05	0	0	None	I	None
8353	90	I/N	None	1.0303	gnomAD-4.0.0	177	None	0.5926	0.683	26.6	N	None	0.8	0.052662	-1.214	0.5101	0.1156	0.489632299804	None	1.0	0.721	0.888503533679	0.994	0.704464256763	-4.51	0.638	0.589	0.001	None	None	1.59872E-06	0	0	0	0	None	0	0	1.59872E-06	0	1.43612E-05	0	None	I	None
8353	90	I/V	None	1.0303	gnomAD-4.0.0	177	None	0.0907	0.1008	22.0	N	None	2.06	0.009248	-1.056	0.0459	-1.0602	0.0704899027279	None	1.0	0.544	0.447803500395	None	0.559894025326	-0.41	0.135	0.315	1.0	None	None	1.37112E-06	0	4.48149E-05	0	0	None	0	0	1.37112E-06	0	0	0	None	I	None

Whole Population MAF	African (AFR)	Latin American (AMR)
Amish (AMS)	Ashkenazi Jewish (ASJ)	East Asian (EAS)
European/1KGP (EUR)	Finnish (FIN)	Middle Eastern (MDE)
Non-Finnish European (NFE)	South Asian (SAS)	Other (OTH)

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